A tricentric schiff base catalyst, a preparation method thereof and a preparation method of polyglycolide

The preparation method of the three-center Schiff base catalyst solves the problems of excessive catalyst dosage and cumbersome Schiff base catalyst purification, and realizes efficient and low-cost PLGA preparation with high number-average molecular weight of poly(lactic-co-liquid) and high yield.

CN117343305BActive Publication Date: 2026-07-03CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES
Filing Date
2023-09-28
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Excessive catalyst usage in current PLGA preparation methods leads to metal residues, reducing thermal stability. Furthermore, the purification of Schiff base catalysts is cumbersome and costly.

Method used

Using a three-center Schiff base catalyst, the preparation method is simplified and solvent-free through the synergistic coordination of the three metal centers. The synthesis process is continuous and can be directly used for the ring-opening polymerization of glycolide and lactide.

Benefits of technology

It improves catalytic activity, has a high number-average molecular weight of poly(ethylene lactide), high yield, reduces production costs, and simplifies the process.

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Abstract

This invention provides a three-center Schiff base catalyst and its preparation method, as well as a method for preparing poly(ethylene glycol) lactide. The three-center Schiff base catalyst has a structure shown in Formula I or Formula II, both of which contain three active sites. The catalytic activity is enhanced through synergistic coordination among the three metal centers. Furthermore, in the preparation method of the catalyst provided by this invention, the synthesis process of the Schiff base compound and the catalyst involves multiple continuous reactions in a one-pot process, saving the purification process of intermediates, reducing the use of organic solvents, simplifying the production process, increasing the catalyst yield, and reducing production costs. This invention uses the catalyst to catalyze the ring-opening polymerization of glycolide and lactide to produce poly(ethylene glycol) lactide. Gel permeation chromatography analysis shows that the prepared poly(ethylene glycol) lactide has a high number-average molecular weight, exceeding 70,000 g / mol, and a high yield, exceeding 94%.
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