A method of preparing nicotine

By using 3-bromopyridine and N-tert-butoxycarbonyl-proline as raw materials, the intermediate was synthesized by photocatalysis and subjected to a mild methylation reaction, which solved the problems of long and dangerous existing nicotine synthesis routes and achieved high-yield industrial production.

CN117362271BActive Publication Date: 2026-06-02HUBEI HENO BIOLOGICAL ENG CO LTD
1 Cites 0 Cited by

Patent Information

Application Number
CN202210773807.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-07-01
Publication Date
2026-06-02
Estimated Expiration
2042-07-01

AI Technical Summary

Technical Problem

Existing methods for preparing nicotine involve long synthetic routes and most of them use hazardous reagents or harsh reaction conditions, making them unsuitable for industrial production.

Method used

Using 3-bromopyridine and N-tert-butyloxycarbonyl-proline as raw materials, the intermediate N-tert-butyloxycarbonyl-nornicotine was synthesized by photocatalysis. Subsequently, the tert-butyloxycarbonyl group was removed and methylation was carried out to synthesize nicotine. Mild reaction conditions and safe reagents were used throughout the process.

Benefits of technology

This method achieves high-yield preparation of nicotine, is suitable for industrial production, simplifies the synthesis steps, and reduces safety risks.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of nicotine. The preparation method of the nicotine comprises the following steps: 3-bromopyridine and N-tert-butoxycarbonyl-proline are used as raw materials to photocatalytically synthesize an intermediate N-tert-butoxycarbonyl-nor-nicotine; then N-tert-butoxycarbonyl-nor-nicotine is reacted with trifluoroacetic acid to remove the tert-butoxycarbonyl group, and nor-nicotine is synthesized; finally, the nor-nicotine is subjected to a methylation reaction to synthesize nicotine. The preparation method of the nicotine has a short synthesis route, is simple to operate, has high yield, is low in cost, and is suitable for industrialized scale production.
Need to check novelty before this filing date? Find Prior Art