A multi-effect soothing composition suitable for infants and its preparation method and application

Abstract

This invention discloses a multi-effect soothing composition suitable for infants, its preparation method, and its application. The multi-effect soothing composition for infants comprises the following components: squalane, jobaba seed oil, ceramide NP, serine, oryzanol, stearyl glycyrrhetinic acid ester, allantoin, and plant extracts. This invention combines squalane, jobaba seed oil, ceramide NP, serine, oryzanol, stearyl glycyrrhetinic acid ester, allantoin, and plant extracts, specifically using a combination of bisabolol and ginger root extract, a combination of Stephania tetrandra extract and gentian extract, and a combination of lotus water, broom leaf and Australian tea extract, and Stephania tetrandra extract. Through the synergistic effect of these components, a multi-effect soothing composition with significant soothing and repairing effects suitable for infant skin is prepared.

Description

Technical Field

[0001] This invention relates to the field of daily chemical product technology, specifically to a multi-effect soothing composition suitable for infants, its preparation method, and its application. Background Technology

[0002] An infant's skin differs from adult skin in structure, function, and composition, being more delicate and fragile. Infant skin is thinner, has an incompletely developed stratum corneum, and lower sebum content, leading to reduced protective capabilities and making it more susceptible to allergic reactions from external factors.

[0003] To protect babies' skin and reduce and alleviate allergies, baby skincare products with soothing and repairing effects are becoming increasingly popular among consumers. Summary of the Invention

[0004] In view of the shortcomings of the prior art, the purpose of this invention is to provide a multi-effect soothing composition suitable for infants, its preparation method and application.

[0005] The objective of this invention is achieved through the following technical solution:

[0006] This invention provides a multi-effect soothing composition suitable for infants, comprising the following components: squalane, jojoba seed oil, ceramide NP, serine, oryzanol, stearyl glycyrrhetinic acid ester, allantoin, and plant extracts.

[0007] Preferably, the plant extracts include: a composition of bisabolol and ginger root extract, a composition of Stephania tetrandra extract and gentian extract, and a composition of lotus water, broom leaf and Australian tea extract and Stephania tetrandra extract.

[0008] Preferably, the multi-effect soothing composition suitable for infants comprises the following components in parts by weight: 5-8 parts squalane, 0.5-2 parts jobaba seed oil, 0.1-0.5 parts water / glycerin / caprylic acid / capric triglyceride / ceramide NP / hydrogenated lecithin / 1,2-hexanediol, 0.2-0.5 parts serine, 0.1-0.2 parts oryzanol, 0.1-0.2 parts stearyl glycyrrhetinic acid ester, 0.1-0.2 parts allantoin, 0.1-0.3 parts bisabolol / ginger root extract, 0.05-0.15 parts water / butylene glycol / Stephania tetrandra extract / gentian extract, and 0.05-0.15 parts lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract.

[0009] Preferably, the weight ratio of the bisabolol / ginger root extract, water / butanediol / Stephania tetrandra extract / gentian extract, lotus water / butanediol / broom leaf Australian tea extract / Stephania tetrandra extract is 2:1:1.

[0010] The present invention also provides the use of the aforementioned multi-effect soothing composition suitable for infants in the preparation of infant skin care products.

[0011] Preferably, the dosage form of the baby skin care product includes any one of cream, lotion, or water.

[0012] The present invention also provides a multi-effect soothing cream for babies, comprising the aforementioned multi-effect soothing composition suitable for babies, and further comprising at least one of a solvent, moisturizer, emulsifier, co-emulsifier, emulsion stabilizer, pH adjuster, chelating agent, thickener, and antioxidant.

[0013] Preferably, the solvent is water;

[0014] The moisturizer is selected from glycerin, butylene glycol, trehalose, 1,3-propanediol, water / butylene glycol / tremella polysaccharide, and ethylhexylglycerin / tocopherol;

[0015] The emollient is selected from pentaerythritol tetra(ethylhexanoate), cetyl ethylhexanoate, caprylic / capric triglyceride, and morrhagic acid fruit oil;

[0016] The emulsifier is selected from glyceryl stearate, cetearyl alcohol / cetearyl glucoside, behenol / polyglycerol-10 pentastearate / sodium stearoyl lactylate;

[0017] The co-emulsifier is selected from cetearyl alcohol and sorbitan stearate;

[0018] The emulsifying stabilizer is selected from stearic acid;

[0019] The chelating agent is selected from 1,3-propanediol / 1,2-hexanediol / octanoyl hydroxamic acid and disodium EDTA;

[0020] The thickener is selected from acrylate / C10-30 alkanol acrylate crosslinked polymers;

[0021] The antioxidant is selected from tocopherol / sunflower seed oil;

[0022] The pH adjuster is selected from tromethamine;

[0023] Preferably, the composition comprises the following components in parts by weight: 5-8 parts squalane, 0.5-2 parts jojoba seed oil, 0.1-0.5 parts water / glycerin / caprylic acid / capric triglyceride / ceramide NP / hydrogenated lecithin / 1,2-hexanediol, 0.2-0.5 parts serine, 0.1-0.2 parts oryzanol, 0.1-0.2 parts stearyl glycyrrhetinic acid ester, 0.1-0.2 parts allantoin, 0.1-0.3 parts bisabolol / ginger root extract, and water / butylene glycol / powder. Gentian extract 0.05-0.15 parts, lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract 0.05-0.15 parts, moisturizer 10-20 parts, emollient 5-10 parts, emulsifier 2-5 parts, co-emulsifier 1-2 parts, emulsion stabilizer 1-2 parts, pH adjuster 0.05-0.1 parts, chelating agent 0.5-1 part, thickener 0.1-0.3 parts, antioxidant 0.1-0.2 parts, solvent to make up to 100 parts.

[0024] The present invention also provides a method for preparing the aforementioned multi-effect soothing cream for infants, comprising the following steps:

[0025] Weigh out the components of the aforementioned multi-effect soothing composition suitable for infants, along with moisturizers, emulsifiers, co-emulsifiers, emulsion stabilizers, pH adjusters, chelating agents, thickeners, and antioxidants in proportion, add them to a solvent, and stir until homogeneous to obtain the aforementioned multi-effect soothing cream for infants.

[0026] Compared with the prior art, the present invention has the following beneficial effects:

[0027] This invention combines squalane, jojoba seed oil, ceramide NP, serine, oryzanol, stearyl glycyrrhetinic acid ester, allantoin, and plant extracts. Specifically, it utilizes a combination of bisabolol and ginger root extract, a combination of Stephania tetrandra extract and gentian extract, and a combination of lotus water, broom leaf and Australian tea extract, and Stephania tetrandra extract. Through the synergistic effect of these components, a multi-effect soothing composition with significant calming and repairing effects suitable for infant skin is prepared. The multi-effect soothing cream for infants prepared based on this composition shows a change rate of transepidermal water loss (TEWL) value of -35.12% to -39.92%, a change rate of red area percentage of -4.89% to -6.31%, and a change rate of lactic acid stinging score of -33.92% to -40.16% after 28 days of use. Attached Figure Description

[0028] Other features, objects, and advantages of the present invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings:

[0029] Figure 1Examples of facial images of subjects using Example 1 as the test sample before use (D0) and 28 days after use (D28). Detailed Implementation

[0030] The present invention will now be described in detail with reference to specific embodiments. These embodiments will help those skilled in the art to further understand the present invention, but do not limit the invention in any way. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention. These all fall within the scope of protection of the present invention.

[0031] The terms "preferred," "more preferably," and "more suitable" used in this invention refer to embodiments of the invention that provide certain beneficial effects under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the description of one or more preferred embodiments does not imply that other embodiments are unavailable, nor is it intended to exclude other embodiments from the scope of this invention.

[0032] It should be understood that, except in any operational instance or otherwise indicated, all figures representing the amounts of ingredients used, for example, in the specification and claims, should be understood to be modified in all cases by the term "about". Therefore, unless otherwise stated, the numerical parameters set forth in the following specification and appended claims are approximations varying with the desired performance to be obtained according to the invention. It is not at all an attempt to limit the application of the doctrine of equivalents to the scope of the claims; each numerical parameter should be interpreted at least according to the number of significant figures reported and by applying ordinary rounding techniques.

[0033] Although the numerical ranges and parameters illustrating the broad scope of the invention are approximate, the values ​​listed in the specific examples are reported as precisely as possible. However, any numerical value inherently contains some error that is necessarily caused by the standard deviation found in their respective test measurements.

[0034] The following examples provide a multi-effect soothing composition suitable for infants, comprising the following components: a composition of squalane, jojoba seed oil, ceramide NP, serine, oryzanol, stearyl glycyrrhetinic acid ester, allantoin, bisabolol and ginger root extract, a composition of Stephania tetrandra extract and gentian extract, and a composition of lotus water, broom leaf Australian tea extract and Stephania tetrandra extract.

[0035] In one specific embodiment, the ceramide NP is derived from commercially available ceramide NP, and its components are: water, glycerol, caprylic acid, caprylic acid triglyceride, ceramide NP, hydrogenated lecithin, and 1,2-hexanediol (i.e., the following water / glycerol / caprylic acid / caprylic acid triglyceride / ceramide NP / hydrogenated lecithin / 1,2-hexanediol). The ceramide NP used in this invention can also be provided by other commercially available raw materials, and this invention does not impose any particular limitation.

[0036] In one specific embodiment, the combination of bisabolol and ginger root extract is derived from commercial products. 100, which may also be provided by other commodity raw materials, is not particularly limited in this invention.

[0037] In one specific embodiment, the composition of the Stephania tetrandra extract and the Gentiana scabra extract is derived from the commercial Gentiana dual-factor anti-allergy agent BGJN1208-2, whose components are: water, butylene glycol, Stephania tetrandra extract, and Gentiana scabra extract (i.e., the following water / butylene glycol / Stephania tetrandra extract / Gentiana scabra extract). The Stephania tetrandra extract and Gentiana scabra extract used in this invention can also be provided by other commercial raw materials, and this invention does not impose any particular limitation.

[0038] In one specific embodiment, the composition of lotus water, broom leaf Australian tea extract, and Stephania tetrandra extract is derived from the commercial product EneSoothe-MIX-ManukaJN1227-1. Its components are: lotus (NELUMBIUM SPECIOSUM) flower water, butylene glycol, broom leaf Australian tea (LEPTOSPERMUM SCOPARIUM) leaf extract, and Stephania tetrandra (STEPHANIA TETRANDRA) extract (i.e., the following lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract). The lotus water, broom leaf Australian tea extract, and Stephania tetrandra extract used in this invention can also be provided by other commercial raw materials; this invention does not impose any particular limitation.

[0039] In one specific embodiment, the multi-effect soothing composition suitable for infants comprises the following components in parts by weight: 5-8 parts squalane, 0.5-2 parts jobaba seed oil, 0.1-0.5 parts water / glycerin / caprylic acid / capric triglyceride / ceramide NP / hydrogenated lecithin / 1,2-hexanediol, 0.2-0.5 parts serine, 0.1-0.2 parts oryzanol, 0.1-0.2 parts stearyl glycyrrhetinic acid ester, 0.1-0.2 parts allantoin, 0.1-0.3 parts bisabolol / ginger root extract, 0.05-0.15 parts water / butylene glycol / Stephania tetrandra extract / gentian extract, and 0.05-0.15 parts lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract.

[0040] The aforementioned multi-effect soothing composition suitable for infants can be used to prepare infant skin care products in any dosage form.

[0041] The following embodiments also specifically provide a multi-effect soothing cream for infants, comprising the following components in parts by weight: 5-8 parts squalane, 0.5-2 parts jojoba seed oil, 0.1-0.5 parts water / glycerin / caprylic / capric triglyceride / ceramide NP / hydrogenated lecithin / 1,2-hexanediol, 0.2-0.5 parts serine, 0.1-0.2 parts oryzanol, 0.1-0.2 parts stearyl glycyrrhetinic acid ester, 0.1-0.2 parts allantoin, and 0.1-0.3 parts bisabolol / ginger root extract. 0.05-0.15 parts of water / butylene glycol / Stephania tetrandra extract / Gentian extract, 0.05-0.15 parts of lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract, 10-20 parts of moisturizer, 5-10 parts of emulsifier, 2-5 parts of emulsifier, 1-2 parts of co-emulsifier, 1-2 parts of emulsion stabilizer, 0.05-0.1 parts of pH adjuster, 0.5-1 part of chelating agent, 0.1-0.3 parts of thickener, 0.1-0.2 parts of antioxidant, and solvent to make up to 100 parts.

[0042] In one specific embodiment, the solvent is water;

[0043] The moisturizer is selected from glycerin, butylene glycol, trehalose, 1,3-propanediol, water / butylene glycol / tremella polysaccharide, and ethylhexylglycerin / tocopherol;

[0044] The emollient is selected from pentaerythritol tetra(ethylhexanoate), cetyl ethylhexanoate, caprylic / capric triglyceride, and morrhagic acid fruit oil;

[0045] The emulsifier is selected from glyceryl stearate, cetearyl alcohol / cetearyl glucoside, behenol / polyglycerol-10 pentastearate / sodium stearoyl lactylate;

[0046] The co-emulsifier is selected from cetearyl alcohol and sorbitan stearate;

[0047] The emulsifying stabilizer is selected from stearic acid;

[0048] The chelating agent is selected from 1,3-propanediol / 1,2-hexanediol / octanoyl hydroxamic acid and disodium EDTA;

[0049] The thickener is selected from acrylate / C10-30 alkanol acrylate crosslinked polymers;

[0050] The antioxidant is selected from tocopherol / sunflower seed oil;

[0051] The pH adjuster is selected from tromethamine.

[0052] In one specific embodiment, the multi-effect soothing baby cream comprises the following components in parts by weight: squalane 5-8 parts, jojoba seed oil 0.5-2 parts, water / glycerin / caprylic / capric triglycerides / ceramide NP / hydrogenated lecithin / 1,2-hexanediol 0.1-0.5 parts, serine 0.2-0.5 parts, oryzanol 0.1-0.2 parts, stearyl glycyrrhetinic acid 0.1-0.2 parts, allantoin 0.1- 0.2 parts, bisabolol / ginger root extract 0.1-0.3 parts, water / butylene glycol / Stephania tetrandra extract / gentian extract 0.05-0.1 parts, lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract 0.05-0.1 parts, glycerin 4-6 parts, butylene glycol 3-5 parts, trehalose 2-5 parts, 1,3-propanediol 1-3 parts, water / butylene glycol / Tremella fuciformis polysaccharide 0.2-0.8 parts, ethylhexyl glycerin Oil / Tocopherol 0.05-0.1 parts, Pentaerythritol Tetra(Ethylhexanoate) ester 2-4 parts, Cetyl Ethylhexanoate ester 2-3 parts, Caprylic / Capric Triglyceride 1-2 parts, Maurice Palm Fruit Oil 0.1-0.3 parts, Glyceryl Stearate ester 1-2 parts, Cetearyl Alcohol / Cetearyl Glucoside 1-2 parts, Behenol / Polyglycerol-10 Pentastearate / Stearoyl Lactoyl Lactate Sodium 0.5-1 part, Cetearyl Alcohol 0.8-1.2 parts 0.5-0.8 parts of sorbitan stearate, 1-2 parts of stearic acid, 0.6-0.8 parts of 1,3-propanediol / 1,2-hexanediol / octanoyl hydroxamic acid, 0.05-0.2 parts of disodium EDTA, 0.1-0.3 parts of acrylate / C10-30 alkanol acrylate crosspolymer, 0.1-0.2 parts of tocopherol / sunflower seed oil, 0.05-0.1 parts of tromethamine, and water to make up to 100 parts.

[0053] In the following examples, all other raw materials used are commercially available.

[0054] Example 1

[0055] This embodiment provides a multi-effect soothing cream for infants, comprising a multi-effect soothing composition suitable for infants (composition: a composition of squalane, jojoba seed oil, ceramide NP, serine, oryzanol, stearyl glycyrrhizate, allantoin, bisabolol and ginger root extract, a composition of Stephania tetrandra extract and gentian extract, a composition of lotus water, broom leaf Australian tea extract and Stephania tetrandra extract), and further comprising solvents, moisturizers, emulsifiers, emulsifiers, co-emulsifiers, emulsion stabilizers, pH adjusters, chelating agents, thickeners, and antioxidants. The composition and weight ratio of each raw material (total weight parts: 100 parts) are shown in Table 1. The specific steps for preparing the soothing cream are as follows:

[0056] 1. Place squalane, pentaerythritol tetra(ethylhexanoate), cetyl ethylhexanoate, caprylic / capric triglyceride, stearic acid, glyceryl stearate, cetearyl alcohol, cetearyl alcohol / cetearyl glucoside, jojoba seed oil, behenol / polyglycerol-10 pentastearate / sodium stearoyl lactylate, sorbitan stearate, oryzanol, stearyl glycyrrhetinic acid ester, bisabolol / ginger (Zingiber officinale) root extract, and tocopherol / helianthus annuus seed oil into an oil phase pot, heat to 75-80℃, stir for 15-20 minutes to mix evenly, and obtain the oil phase material;

[0057] 2. Add water, glycerin, butylene glycol, trehalose, 1,3-propanediol, acrylate / C10-30 alkanol acrylate crosspolymer, allantoin, and disodium EDTA to a mixing bowl, stir until homogenized, heat to 80°C, and homogenize at 1000 rpm for 1-2 minutes.

[0058] 3. Keep the temperature of the mixing pot at 75-80℃, put the oil phase material obtained in step 1 into the mixing pot, homogenize at 2500rpm for 5min, and stir for 15min to dissolve evenly;

[0059] 4. Cool the mixing pot to 65°C, mix a small amount of water and tromethorphan evenly, then add it to the mixing pot, homogenize at 2500 rpm for 2 minutes, and stir for 10 minutes to dissolve evenly;

[0060] 5. Cool the mixing pot to 40℃. First, dissolve the serine in a small amount of water until homogeneous. Then, add it to the mixing pot along with 1,3-propanediol / 1,2-hexanediol / caprylyl hydroxamic acid, water / glycerin / caprylic acid / capric triglyceride / ceramide NP / hydrogenated lecithin / 1,2-hexanediol, water / butanediol / Tremella fuciformis polysaccharide, Mauritia flaxusa fruit oil, ethylhexylglycerin / tocopherol (vitamin E), water / butanediol / Stephania tetrandra extract / Gentiana scabra extract, Nelumbo nucifera flower water / butanediol / Leptospermum scoparium leaf extract / Stephania tetrandra extract. Stir for 15-20 minutes until homogeneous.

[0061] 6. Cool to 38℃, vacuum, filter and remove from the pot to obtain the baby multi-effect soothing cream.

[0062] Example 2

[0063] This embodiment provides a multi-effect soothing cream for babies, the composition and weight ratio of its ingredients (total weight parts of 100) are shown in Table 1. The preparation steps of the multi-effect soothing cream for babies are the same as those in Embodiment 1.

[0064] Example 3

[0065] This embodiment provides a multi-effect soothing cream for babies, the composition and weight ratio of its ingredients (total weight parts of 100) are shown in Table 1. The preparation steps of the multi-effect soothing cream for babies are the same as those in Embodiment 1.

[0066] Example 4

[0067] This embodiment provides a multi-effect soothing cream for babies, the composition and weight ratio of its ingredients (total weight parts of 100) are shown in Table 1. The preparation steps of the multi-effect soothing cream for babies are the same as those in Embodiment 1.

[0068] Example 5

[0069] This embodiment provides a multi-effect soothing cream for babies, the composition and weight ratio of its ingredients (total weight parts of 100) are shown in Table 1. The preparation steps of the multi-effect soothing cream for babies are the same as those in Embodiment 1.

[0070] Table 1

[0071]

[0072]

[0073] Comparative Example 1

[0074] This comparative example provides a multi-effect soothing baby cream. The composition and weight ratio of its ingredients (total weight parts of 100) are shown in Table 2. Compared with Example 1, squalane is used in 6 parts by weight, and jojoba seed oil is not added. The preparation steps of the multi-effect soothing baby cream are the same as those in Example 1.

[0075] Comparative Example 2

[0076] This comparative example provides a multi-effect soothing cream for babies. The composition and weight ratio of its ingredients (total weight parts: 100 parts) are shown in Table 2. Compared to Example 1, it uses 5.5 parts by weight of squalane and does not contain water, glycerin, caprylic acid, caprylic acid triglyceride, ceramide NP, hydrogenated lecithin, or 1,2-hexanediol. The preparation steps of the multi-effect soothing cream for babies are the same as in Example 1.

[0077] Comparative Example 3

[0078] This comparative example provides a multi-effect soothing baby cream. The composition and weight ratio of its ingredients (total weight parts: 100 parts) are shown in Table 2. Compared with Example 1, squalane is used in 5.2 parts by weight, and serine is not added. The preparation steps of the multi-effect soothing baby cream are the same as those in Example 1.

[0079] Comparative Example 4

[0080] This comparative example provides a multi-effect soothing cream for babies. The composition and weight ratio of its ingredients (total weight parts: 100 parts) are shown in Table 2. Compared with Example 1, squalane is used in 5.1 parts by weight, and oryzanol is not added. The preparation steps of the multi-effect soothing cream for babies are the same as those in Example 1.

[0081] Comparative Example 5

[0082] This comparative example provides a multi-effect soothing cream for babies, the composition and weight ratio of its ingredients (total weight parts of 100) are shown in Table 2. Compared with Example 1, squalane is used in 5.1 parts by weight, and stearyl glycyrrhetinic acid ester is not added. The preparation steps of the multi-effect soothing cream for babies are the same as those in Example 1.

[0083] Comparative Example 6

[0084] This comparative example provides a multi-effect soothing baby cream. The composition and weight ratio of its ingredients (total weight parts: 100 parts) are shown in Table 2. Compared to Example 1, it uses 0.2 parts by weight of bisabolol / ginger root extract, and does not add water / butylene glycol / Stephania tetrandra extract / gentian extract or lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract. The preparation steps of the multi-effect soothing baby cream are the same as in Example 1.

[0085] Comparative Example 7

[0086] This comparative example provides a multi-effect soothing baby cream. The composition and weight ratio of its ingredients (total weight parts: 100 parts) are shown in Table 2. Compared to Example 1, water / butylene glycol / Stephania tetrandra extract / gentian extract are not added; instead, lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract are used in a weight ratio of 0.1 parts. The preparation steps of the multi-effect soothing baby cream are the same as in Example 1.

[0087] Comparative Example 8

[0088] This comparative example provides a multi-effect soothing baby cream. The composition and weight ratio of its ingredients (total weight parts: 100 parts) are shown in Table 2. Compared to Example 1, lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract are not added; instead, water / butylene glycol / Stephania tetrandra extract / gentian extract are used in a weight ratio of 0.1 parts. The preparation steps of the multi-effect soothing baby cream are the same as in Example 1.

[0089] Table 2

[0090]

[0091]

[0092] Efficacy verification:

[0093] The multi-effect soothing baby creams prepared in Examples 1-5 and Comparative Examples 1-8 were used as test samples. Recruited, qualified subjects were selected as test subjects. The soothing, repairing, and moisturizing effects, as well as suitability for sensitive skin, of the test samples were evaluated using instrumental testing, image analysis, semi-subjective evaluation, and subjective evaluation methods. Specific test methods used were derived from: PONY-SOPR-22514.02 "Test Method for Soothing Efficacy of Cosmetics", PONY-SOPR-22714.02 "Test Method for Repairing Efficacy of Cosmetics", PONY-SOPR-22814.01 "Test Method for Long-Lasting Moisturizing Efficacy of Cosmetics", and PONY-SOPR-22114.01 "Test Method for Suitability of Cosmetics for Sensitive Skin".

[0094] 1) Test subjects: Healthy women / men aged 21-57 years, with an initial TEWL value greater than 15 g / m2 / h, and a positive lactic acid stinging screening result (50 μL of 10% lactic acid solution was applied to the nasolabial fold and one cheek. Subjects were asked about their subjective symptoms at 2.5 min and 5 min, and scored on a 4-point scale: 0 points for no stinging sensation, 1 point for mild stinging sensation, 2 points for moderate stinging sensation, and 3 points for severe stinging sensation. The two scores were then added together, and a total score ≥3 points was considered a positive lactic acid stinging reaction).

[0095] 2) Testing instruments and reagents

[0096] 2.1 MPA580 Skin Elasticity Tester (Tewameter Probe)

[0097] 2.2 VISIA-CR Facial Image Analyzer

[0098] 2.3 Analytical Balance

[0099] 3) Testing Environment

[0100] The test was conducted in an environment with a temperature of 21±1℃ and a relative humidity of 50±10%RH. Subjects were required to acclimatize to this environment for at least 30 minutes before the assessment and testing could be performed.

[0101] 4) Test Indicators

[0102] Transepidermal water loss (TEWL) value: Detected using an MPA580 skin elasticity tester (Tewameter probe), with the measurement area being the cheek; a smaller TEWL value indicates better recovery of transepidermal water loss in skin with a damaged barrier.

[0103] Red area percentage: The facial image analyzer VISIA-CR was used for detection, and the measurement area was the cheek. The larger the red area percentage, the more obvious the signs of skin barrier damage, erythema, and telangiectasia.

[0104] Lactic acid stinging test: 50 μl of 10% lactic acid was dropped onto a single layer of filter paper with a diameter of 0.8 cm and placed on the nasolabial groove of the subject. The subject was asked about the stinging sensation and the skin reaction was observed at 2.5 min and 5 min. The stinging sensation was scored from 0 to 3 points, with no stinging sensation, mild stinging sensation, moderate stinging sensation and severe stinging sensation.

[0105] 5) Testing methods

[0106] After the subjects were grouped (n≥10), each test sample was used twice daily, once in the morning and once in the evening, replacing their usual cream. Other skincare products were used as usual. Various indicators were tested before using each test sample (day D0), 14 days after using each test sample (day D14), and 28 days after using each test sample (day D28).

[0107] Before the test, the subject's area needs to be cleaned and the subject waits: The subject cleans his / her face with a dry paper towel and sits quietly for 30 minutes in a laboratory with a temperature of 21℃±1℃ and a humidity of 50%±10%RH; then the subject's various test data are collected (transdermal water loss TEWL value, red area percentage, skin stratum corneum moisture content and lactic acid stinging score).

[0108] 6) Test Results

[0109] 6.1 The results of the change rate of transdermal water loss (TEWL) values ​​(compared to the TEWL values ​​before use) of each group of subjects after 14 days and 28 days of using the test sample are shown in Table 3 (the results are average values).

[0110] Table 3

[0111]

[0112]

[0113] 6.2 The results of the change rate of red area percentage (compared to the red area percentage before use) and lactic acid stinging score (compared to the red area percentage and lactic acid stinging score before use) of each group of subjects after using the test sample for 28 days are shown in Table 4 (the results are average values).

[0114] Table 4

[0115]

[0116] As shown in Table 3, the baby multi-effect soothing creams prepared in each example, when used as test samples, significantly reduced the transepidermal water loss (TEWL) value compared to before use. The TEWL value change rate was -15.34% to -18.34% after 14 days of use and -35.12% to -39.92% after 28 days of use. Furthermore, a comparison of the effects of Example 1 and Comparative Examples 1-5 shows that when the baby-suitable multi-effect soothing composition used in the baby multi-effect soothing cream did not contain jojoba seed oil, water / glycerin / caprylic acid / capric acid triglyceride / ceramide NP / hydrogenated lecithin / 1,2-hexanediol, serine, oryzanol, or stearyl glycyrrhetinic acid ester, the TEWL value reduction rate increased to varying degrees, indicating that these ingredients have a synergistic effect in reducing transepidermal water loss.

[0117] As shown in Table 4, the multi-effect baby soothing creams prepared in each example, when used as test samples, significantly reduced the proportion of red area and lactic acid stinging score after use compared to before use. After 28 days of use, the change rate of red area proportion ranged from -4.89% to -6.31%, and the change rate of lactic acid stinging score ranged from -33.92% to -40.16%. Furthermore, a comparison of the effects of Example 1 and Comparative Examples 1-5 shows that when the multi-effect soothing composition used in the baby-suitable cream did not contain jojoba seed oil, water / glycerin / caprylic acid / capric acid triglyceride / ceramide NP / hydrogenated lecithin / 1,2-hexanediol, serine, oryzanol, or stearyl glycyrrhetinic acid ester, the proportion of red area and lactic acid stinging score increased to varying degrees. This indicates that these ingredients have a synergistic effect in reducing the proportion of red area and lactic acid stinging score. The comparison of the effects of Example 1 and Comparative Examples 6-8 shows that when only one or two of the following ingredients are used in the multi-effect soothing composition suitable for infants in the baby multi-effect soothing cream: bisabolol / ginger root extract, water / butylene glycol / Stephania tetrandra extract / gentian extract, and lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract, the rate of change in the red area ratio and lactic acid stinging score increases significantly. This indicates that the combined effect of these three ingredients can significantly reduce the red area ratio and lactic acid stinging score. The comparison of the effects of Example 2 and Examples 4-5 shows that when the ratio of bisabolol / ginger root extract, water / butylene glycol / Stephania tetrandra extract / gentian extract, and lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract is 2:1:1, the red area ratio and lactic acid stinging score can be further reduced.

[0118] Figure 1Examples of facial images of two subjects using the test sample of Example 1 before (D0) and after (D28) use, provided by Figure 1 It is evident that the red area on the face of the subjects using the test sample of Example 1 was significantly reduced.

[0119] In addition, no adverse skin reactions were observed in any of the subjects after using the test samples for 28 days.

[0120] As can be seen from the above test results, the multi-effect soothing composition for infants prepared in this invention has obvious soothing and repairing effects on the skin and is suitable for infant skin.

[0121] This invention has many specific applications, and the above description is only a preferred embodiment. It should be noted that the above embodiments are for illustrative purposes only and are not intended to limit the scope of protection of this invention. For those skilled in the art, several improvements can be made without departing from the principle of this invention, and these improvements should also be considered within the scope of protection of this invention.

Claims

1. A multi-effect soothing composition suitable for infants, characterized in that, The product comprises the following components in parts by weight: 5-8 parts squalane, 0.5-2 parts jojoba seed oil, 0.1-0.5 parts water / glycerin / caprylic acid / capric triglyceride / ceramide NP / hydrogenated lecithin / 1,2-hexanediol, 0.2-0.5 parts serine, 0.1-0.2 parts oryzanol, 0.1-0.2 parts stearyl glycyrrhetinic acid ester, 0.1-0.2 parts allantoin, 0.1-0.3 parts bisabolol / ginger root extract, 0.05-0.15 parts water / butylene glycol / Stephania tetrandra extract / gentian extract, and 0.05-0.15 parts lotus water / butylene glycol / broom leaf Australian tea extract / Stephania tetrandra extract. The weight ratio of the bisabolol / ginger root extract, water / butanediol / Stephania tetrandra extract / gentian extract, lotus water / butanediol / broom leaf Australian tea extract / Stephania tetrandra extract is 2:1:

1.

2. The use of the multi-effect soothing composition for infants according to claim 1 in the preparation of infant skin care products.

3. The application according to claim 2, characterized in that, The dosage form of the infant skin care products includes any one of cream, lotion, and liquid.

4. A multi-effect soothing cream for babies, characterized in that, The multi-effect soothing composition suitable for infants as described in claim 1 further includes at least one of the following: solvent, moisturizer, emollient, emulsifier, co-emulsifier, emulsion stabilizer, pH adjuster, chelating agent, thickener, and antioxidant.

5. The multi-effect soothing baby cream according to claim 4, characterized in that, The solvent is water; The moisturizer is selected from glycerin, butylene glycol, trehalose, 1,3-propanediol, water / butylene glycol / tremella polysaccharide, and ethylhexylglycerin / tocopherol; The emollient is selected from pentaerythritol tetra(ethylhexanoate), cetyl ethylhexanoate, caprylic / capric triglyceride, and morrhagic acid fruit oil; The emulsifier is selected from glyceryl stearate, cetearyl alcohol / cetearyl glucoside, behenol / polyglycerol-10 pentastearate / sodium stearoyl lactylate; The co-emulsifier is selected from cetearyl alcohol and sorbitan stearate; The emulsifying stabilizer is selected from stearic acid; The chelating agent is selected from 1,3-propanediol / 1,2-hexanediol / octanoyl hydroxamic acid and disodium EDTA; The thickener is selected from acrylate / C10-30 alkanol acrylate crosslinked polymers; The antioxidant is selected from tocopherol / sunflower seed oil; The pH adjuster is selected from tromethamine.

6. The multi-effect soothing baby cream according to claim 4 or 5, characterized in that, The product comprises the following components in parts by weight: squalane 5-8 parts, jojoba seed oil 0.5-2 parts, water / glycerin / caprylic acid / capric triglyceride / ceramide NP / hydrogenated lecithin / 1,2-hexanediol 0.1-0.5 parts, serine 0.2-0.5 parts, oryzanol 0.1-0.2 parts, stearyl glycyrrhetinic acid 0.1-0.2 parts, allantoin 0.1-0.2 parts, bisabolol / ginger root extract 0.1-0.3 parts, water / butanediol / Stephania tetrandra extract. Extracts: 0.05-0.15 parts of gentian extract, 0.05-0.15 parts of lotus water, 0.05-0.15 parts of safflower leaf extract, 0.05-0.15 parts of broom leaf extract, 10-20 parts of moisturizer, 5-10 parts of emulsifier, 2-5 parts of emulsifier, 1-2 parts of co-emulsifier, 1-2 parts of emulsion stabilizer, 0.05-0.1 parts of pH adjuster, 0.5-1 part of chelating agent, 0.1-0.3 parts of thickener, 0.1-0.2 parts of antioxidant, and solvent to bring the total to 100 parts.

7. A method for preparing a multi-effect soothing baby cream according to any one of claims 5-6, characterized in that, Includes the following steps: Weigh out each component of the multi-effect soothing composition suitable for infants according to claim 1, as well as moisturizers, emulsifiers, co-emulsifiers, emulsion stabilizers, pH adjusters, chelating agents, thickeners, and antioxidants in proportion, add them to the solvent, and stir evenly to obtain the multi-effect soothing cream for infants.

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