Microreactor and mixing method thereof

Abstract

This invention discloses a microreactor mixer and its mixing method. The microreactor mixer includes a feed plate, a distribution plate, and a mixing plate, which are sequentially assembled and fixed from bottom to top into a single structure. The feed plate conveys materials to the distribution plate, which separates the different materials conveyed by the feed plate into flat, interleaved fluids. The mixing plate mixes the separated materials in the distribution plate together. This invention mixes materials that flow out of the flat outlet in multiple stages, creating interleaved flow patterns. The larger surfaces of the interleaved and dispersed flat sheet-like materials come into contact and mix, resulting in a large mixing contact area. This facilitates the mixing of finer materials, and the interleaved flow patterns allow for rapid mixing of different materials when they come into contact in different channels, ensuring timely and effective mixing of the two materials.

Description

Technical Field

[0001] This invention relates to the field of microreactor technology, and more specifically to a microreactor mixer and its mixing method. Background Technology

[0002] A microreactor is a three-dimensional structural element manufactured on a solid matrix using specialized microfabrication techniques, designed to facilitate chemical reactions. It typically contains small channel sizes and a variety of channels through which fluids flow, and within these channels, the desired reactions are required to occur. Applications of microreactors primarily focus on production processes, energy and the environment, chemical research tools, drug development and biotechnology, and analytical applications.

[0003] Liposomes are hollow liposomes made from lecithin and ceramides, etc. They have a bilayer structure that is the same as that of skin cell membranes. In pharmaceutical applications, drugs are encapsulated in the molecular layer of liposomes to form microvesicles. Taking advantage of the fact that liposomes can fuse with cell membranes, drugs are delivered into the cells.

[0004] Liposomes are typically produced using microreactors. These microreactors allow multiple raw materials to be mixed to form liposomes. Existing microreactors consist of a curved mixing channel on a single sheet. Multiple raw materials are sequentially injected into the mixing channel for mixing. The mixture flows through the curved channel, allowing the different raw materials to mix. However, this mixing method is prone to uneven mixing due to the pressure acting on the raw materials after they are added. This results in insufficient liposome formation. Summary of the Invention

[0005] The purpose of this invention is to solve the above-mentioned technical problems and provide a microreactor and its mixing method.

[0006] To achieve the above objectives, the present invention employs the following technical solution:

[0007] A microreactor mixer includes a feed plate, a distribution plate, and a mixing plate, which are sequentially assembled and fixed from bottom to top into a single structure. The feed plate conveys materials to the distribution plate, which separates the different materials conveyed by the feed plate into flat, interleaved fluids. The mixing plate mixes the materials separated in the distribution plate. Specifically, the flat sections are defined as having a width dimension less than one-tenth of their length dimension.

[0008] Furthermore, the side of the feeding plate has a first feeding hole and a second feeding hole arranged in parallel, and the upper surface of the feeding plate has a first vertical feeding channel and a second vertical feeding channel arranged in a row. The first vertical feeding channel communicates with the first feeding hole, and the second vertical feeding channel communicates with the second feeding hole. Both the first and second vertical feeding channels are elongated and arranged perpendicular to the axis of the first feeding hole. Multiple first and second vertical feeding channels are arranged in a row, and the first and second vertical feeding channels are arranged alternately. The material distribution... The plate has a first and a second material distribution hole that are vertically connected. The first material distribution hole is connected to the first vertical feeding channel and arranged in a row along the length of the first vertical feeding channel. The second material distribution hole is connected to the second vertical feeding channel and arranged in a row along the length of the second vertical feeding channel. The first and second material distribution holes are arranged alternately. The mixing plate has a mixing groove that is vertically connected to the mixing plate. Multiple mixing grooves are arranged in parallel. Each mixing groove is located above the first and second material distribution holes in the same row so as to mix the materials diverted from the first and second material distribution holes in the mixing groove.

[0009] Furthermore, the first material distribution hole includes a first connecting hole segment and a first elongated hole segment, the width of the first elongated hole segment being smaller than the width of the first connecting hole segment. The first connecting hole segment is located above the first vertical feeding channel, and the first elongated hole segment is located on the upper surface of the feeding plate, with the lower part of the first elongated hole segment blocked by the upper surface of the feeding plate. The second material distribution hole includes a second connecting hole segment and a second elongated hole segment, the width of the second elongated hole segment being smaller than the width of the second connecting hole segment. The second connecting hole segment is located above the second vertical feeding channel, and the second elongated hole segment is located on the upper surface of the feeding plate, with the lower part of the second elongated hole segment blocked by the upper surface of the feeding plate. The first elongated hole segment and the second elongated hole segment are arranged parallel to each other.

[0010] Furthermore, the first material distribution hole is arranged perpendicular to the cross-section of the first vertical feeding channel; the second material distribution hole is arranged perpendicular to the cross-section of the second vertical feeding channel.

[0011] Furthermore, it also includes a discharge plate located above the mixing plate. The lower end of the discharge plate has a first groove with its opening facing downward and covering the upper port of the mixing tank to concentrate and output the mixture in the mixing tank. A discharge hole is provided on one side of the discharge plate, and the discharge hole extends to communicate with the first groove to discharge the mixture in the first groove.

[0012] Furthermore, a bracket is fixedly connected to the discharge hole, and a first rotating shaft is rotatably connected to the middle of the bracket, with a spiral blade fixedly connected to the first rotating shaft.

[0013] Furthermore, one end of the first rotating shaft extends into the first groove and is fixedly connected to a first gear. A second gear is rotatably connected to the side wall of the first groove. The first gear and the second gear are driven by gear meshing. A pin is fixedly connected to the end of the second gear at an eccentric position. A stop block is fixedly connected to the side wall of the first groove. A fixed mesh plate is fixedly connected inside the first groove. The fixed mesh plate is located below the stop block. A movable mesh plate is provided above the fixed mesh plate. The movable mesh plate is slidably connected between the fixed mesh plate and the stop block. A driving block is fixedly connected to the upper end of the movable mesh plate. The driving block has vertically arranged sliding grooves. The pin is inserted into the sliding grooves. The second gear rotates to make the driving block swing back and forth. When the mixture flows out of the discharge hole, it drives the spiral blades to rotate, causing the first shaft to rotate, which in turn drives the first gear to rotate. The first gear drives the second gear to rotate through gear engagement. The rotation of the second gear drives the eccentric pin to rotate, and the rotation of the pin drives the drive block to swing back and forth, thereby causing the movable mesh plate to swing back and forth relative to the fixed mesh plate to further mix the material.

[0014] Furthermore, an annular sealing groove is provided on the upper surface of the feeding plate, the distributing plate and the mixing plate, and a sealing ring is provided in the annular sealing groove.

[0015] Another aspect of the present invention provides a mixing method using a microreactor mixer, comprising the following steps:

[0016] Step 1: The two different fluid materials are conveyed to the first feed port and the second feed port respectively through the conveying pipe;

[0017] Step two: The fluid material in the first feed hole is diverted through the first vertical feed channel and enters the first distribution hole, and then enters the mixing tank through the first elongated hole section; the fluid material in the second feed hole is diverted through the second vertical feed channel and enters the second distribution hole, and then enters the mixing tank through the second elongated hole section; the two dispersed fluid materials are mixed in the mixing tank;

[0018] Step 3: After the materials in the mixing tank are mixed, they enter the first groove and are concentrated. They are further mixed and reacted by the fixed mesh plate and the moving mesh plate, which swings back and forth. The mixed fluid material is then output to the external equipment through the discharge hole.

[0019] The present invention provides a micro-reaction mixer and its mixing method, which has the following beneficial effects: by mixing materials that flow out from the flat outlet in multiple stages and are interleaved, the larger surfaces of the interleaved and dispersed flat sheet materials come into contact with each other, resulting in a large mixing contact area. This facilitates the contact and mixing of finer materials. Furthermore, the interleaved materials and the materials formed in different channels can quickly generate a mixed fluid when they come into contact, allowing the two materials to mix in a timely and effective manner, thereby fully forming liposomes. Attached Figure Description

[0020] The specific embodiments of the present invention will be described in further detail below with reference to the accompanying drawings:

[0021] Figure 1 A three-dimensional structural diagram of a microreactor mixer provided by the present invention. Figure 1 ;

[0022] Figure 2 A three-dimensional structural diagram of a microreactor mixer provided by the present invention. Figure 2 ;

[0023] Figure 3 A top view cross-sectional diagram of the feed plate in a microreactor provided by the present invention;

[0024] Figure 4 A top view of the distribution plate in a microreactor provided by the present invention;

[0025] Figure 5 A top view of the mixing plate in a microreactor provided by the present invention;

[0026] Figure 6 A three-dimensional perspective view of the feed plate in a microreactor provided by the present invention;

[0027] Figure 7 A three-dimensional perspective structural diagram of the feed plate and the distribution plate in a microreactor provided by the present invention;

[0028] Figure 8 A schematic diagram illustrating the interaction between the first and second feed holes and the first and second vertical feed channels in a microreactor provided by the present invention.

[0029] Figure 9 A schematic diagram illustrating the interaction between the first dispensing hole, the second dispensing hole, and the mixing tank in a microreactor provided by the present invention;

[0030] Figure 10 A schematic diagram of the lateral cross-sectional structure of a microreactor mixer provided by the present invention;

[0031] Figure 11 for Figure 10 Schematic diagram of a partial structure at part A in the middle;

[0032] Figure 12 for Figure 11 A side view of the drive block section;

[0033] Figure 13 This is an enlarged schematic diagram of the liposomes prepared according to the present invention.

[0034] The following are the labels in the diagram: 1. Feed plate; 11. First feed hole; 12. Second feed hole; 13. First vertical feed channel; 14. Second vertical feed channel; 2. Distributor plate; 21. First distribution hole; 211. First connecting hole section; 212. First elongated hole section; 22. Second distribution hole; 221. Second connecting hole section; 222. Second elongated hole section; 3. Mixing plate; 31. Mixing trough; 4. Discharge plate; 41. First groove; 42. Discharge hole; 5. Support; 51. First rotating shaft; 52. Spiral blade; 53. First gear; 54. Second gear; 55. Pin; 56. Stop block; 57. Fixed mesh plate; 58. Movable mesh plate; 59. Drive block; 591. Sliding groove; 6. Annular sealing groove. Detailed Implementation

[0035] It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

[0036] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0037] It should be noted that in the embodiments of the present invention, all directional indications (such as up-down-left-right-forward-backward...) are only used to explain the relative positional relationship and movement between the components in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indication will also change accordingly. The connection can be a direct connection or an indirect connection.

[0038] like Figures 1-12As shown, a microreactor mixer includes a feed plate 1, a distribution plate 2, and a mixing plate 3. The feed plate 1, distribution plate 2, and mixing plate 3 are sequentially assembled and fixed from bottom to top into a single structure. The feed plate 1 conveys materials to the distribution plate 2, which separates the different materials conveyed by the feed plate 1 into flat, interleaved fluids. The mixing plate 3 mixes the materials separated in the distribution plate 2. Specifically, the flat shape is defined as having a width dimension less than one-tenth of its length dimension.

[0039] Using the above scheme, the material is divided into multiple layers of feed plate 1, distribution plate 2 and mixing plate 3 working together to mix the materials that flow out of the flat outlet in an interlaced manner. The larger surfaces of the interlaced and dispersed flat sheet materials come into contact with each other and mix, resulting in a large mixing contact area. This facilitates the contact and mixing of finer materials. The interlacing of different materials and the rapid generation of mixed fluids when materials in different channels come into contact with each other allows for timely and effective mixing of the two materials, thereby fully forming liposomes.

[0040] Specifically, the side of the feeding plate 1 has a first feeding hole 11 and a second feeding hole 12 arranged in parallel. The upper surface of the feeding plate 1 has a first vertical feeding channel 13 and a second vertical feeding channel 14 arranged in a row. The first vertical feeding channel 13 communicates with the first feeding hole 11, and the second vertical feeding channel 14 communicates with the second feeding hole 12. Both the first vertical feeding channel 13 and the second vertical feeding channel 14 are elongated and arranged perpendicular to the axis of the first feeding hole. Multiple first vertical feeding channels 13 and second vertical feeding channels 14 are arranged in a row, and the first vertical feeding channels 13 and second vertical feeding channels 14 are arranged alternately. The separating plate 2 has... The mixing plate 3 has a first distributing hole 21 and a second distributing hole 22 that are vertically connected. The first distributing hole 21 is connected to the first vertical feeding channel 13 and arranged in a row along the length of the first vertical feeding channel 13. The second distributing hole 22 is connected to the second vertical feeding channel 14 and arranged in a row along the length of the second vertical feeding channel 14. The first distributing hole 21 and the second distributing hole 22 are arranged alternately. The mixing plate 3 has a mixing groove 31 that is vertically connected to the mixing plate 3. Multiple mixing grooves 31 are arranged in parallel. Each mixing groove 31 is located above the first distributing hole 21 and the second distributing hole 22 in the same row so as to mix the materials diverted from the first distributing hole 21 and the second distributing hole 22 in the mixing groove 31.

[0041] In use, materials enter the feed plate 1 through the first feed hole 11 and the second feed hole 12 respectively. The materials are separated into multiple fluids by the first vertical feed channel 13 or the second vertical feed channel 14 arranged in a row. The two materials are conveyed upward into the first distribution hole 21 and the second distribution hole 22 through the first vertical feed channel 13 and the second vertical feed channel 14 respectively. Each fluid in the first vertical feed channel 13 and the second vertical feed channel 14 is further separated into multiple channels by the first distribution hole 21 or the second distribution hole 22 arranged in a row above. The two materials are arranged in a crisscrossing manner. The two materials separated into multiple channels and intersecting with each other are conveyed to the mixing tank 31 to mix into a mixed fluid, thereby improving the mixing efficiency and promoting more thorough mixing.

[0042] Specifically, the first dispensing hole 21 includes a first connecting hole segment 211 and a first elongated hole segment 212 that are connected together. The width of the first elongated hole segment 212 is smaller than the width of the first connecting hole segment 211. The first connecting hole segment 211 is located above the first vertical feeding channel 13, and the first elongated hole segment 212 is located on the upper surface of the feeding plate 1, with the lower part of the first elongated hole segment 212 blocked by the upper surface of the feeding plate 1. The second dispensing hole 22 includes a second connecting hole segment 221 and a second elongated hole segment 222 that are connected together. The width of the second elongated hole segment 222 is smaller than the width of the second connecting hole segment 221. The second connecting hole segment 221 is located above the second vertical feeding channel 14, and the second elongated hole segment 222 is located on the upper surface of the feeding plate 1, with the lower part of the second elongated hole segment 222 blocked by the upper surface of the feeding plate 1. The first elongated hole segment 212 and the second elongated hole segment 222 are arranged parallel to each other. The widths of the first connecting hole section 211 and the second connecting hole section 221 are greater than those of the first elongated hole section 212 and the second elongated hole section 222, respectively. The wider first connecting hole section 211 and the second connecting hole section 221 facilitate the introduction of materials from the first vertical feeding channel 13 and the second vertical feeding channel 14 into the first distributing hole 21 and the second distributing hole 22, respectively. The narrower first elongated hole section 212 and the second elongated hole section 222 make the materials more dispersed and facilitate the contact between different materials during mixing.

[0043] Specifically, the first material distribution hole 21 is arranged perpendicular to the cross-section of the first vertical feeding channel 13; the second material distribution hole 22 is arranged perpendicular to the cross-section of the second vertical feeding channel 14.

[0044] Specifically, it also includes a discharge plate 4, which is located above the mixing plate 3. The lower end of the discharge plate 4 has a first groove 41, the opening of which faces downwards and covers the upper port of the mixing tank 31 to concentrate and output the mixture in the mixing tank 31. A discharge hole 42 is provided on one side of the discharge plate 4, extending to communicate with the first groove 41 to discharge the mixture in the first groove 41. The material in the mixing tank 31 is concentrated and remixed through the first groove 41 before being discharged, thus allowing the mixed fluid to be discharged.

[0045] Specifically, a bracket 5 is fixedly connected to the discharge hole 42, and a first rotating shaft 51 is rotatably connected to the middle of the bracket 5. A spiral blade 52 is fixedly connected to the first rotating shaft 51. The mixed fluid material flows out of the discharge hole 42. When the mixed material flows out, it drives the spiral blade 52 to rotate. The rotation of the spiral blade 52 further mixes the mixed material, making the material more thoroughly mixed and improving the mixing effect.

[0046] Specifically, one end of the first rotating shaft 51 extends into the first groove 41 and is fixedly connected to a first gear 53. A second gear 54 is rotatably connected to the side wall of the first groove 41. The first gear 53 and the second gear 54 are driven by gear meshing. A pin 55 is fixedly connected to the end of the second gear 54 at an eccentric position. A stop block 56 is fixedly connected to the side wall of the first groove 41. A fixed mesh plate 57 is fixedly connected inside the first groove 41. The fixed mesh plate 57 is located below the stop block 56. A movable mesh plate 58 is provided above the fixed mesh plate 57. The movable mesh plate 58 is slidably connected between the fixed mesh plate 57 and the stop block 56. A driving block 59 is fixedly connected to the upper end of the movable mesh plate 58. A sliding groove 591 arranged vertically is provided on the driving block 59. The pin 55 is inserted in the sliding groove 591. The second gear 54 rotates to make the driving block 59 swing back and forth. When the mixture flows out of the discharge hole 42, it drives the spiral blade 52 to rotate, causing the first rotating shaft 51 to rotate, which in turn drives the first gear 53 to rotate. The first gear 53 drives the second gear 54 to rotate through gear engagement. The rotation of the second gear 54 drives the eccentric pin 55 to rotate. The rotation of the pin 55 drives the drive block 59 to swing back and forth, thereby causing the movable mesh plate 58 to swing back and forth relative to the fixed mesh plate 57 to further mix the material.

[0047] Specifically, annular sealing grooves 6 are formed on the upper surfaces of the feed plate 1, the distribution plate 2, and the mixing plate 3, and sealing rings are provided in the annular sealing grooves 6. The sealing rings enable a sealed fit between the contact surfaces of the feed plate 1, the distribution plate 2, the mixing plate 3, and the discharge plate 4.

[0048] In another embodiment, a mixing method using a microreactor mixer, employing the aforementioned microreactor mixer, comprises the following steps:

[0049] Step 1: Two different fluid materials, such as ethanol-soluble lipids and water-soluble drugs, are respectively transported through the conveying pipes to the first feed port 11 and the second feed port 12.

[0050] Step two: The fluid material in the first feed hole 11 is diverted through the first vertical feed channel 13 and enters the first distribution hole 21, and then diverted through the first elongated section 212 into the mixing tank 31; the fluid material in the second feed hole 12 is diverted through the second vertical feed channel 14 and enters the second distribution hole 22, and then diverted through the second elongated section 222 into the mixing tank 31; the two dispersed fluid materials are mixed in the mixing tank 31;

[0051] Step three: After mixing in the mixing tank 31, the materials are concentrated in the first groove 41 and further mixed and reacted by the fixed mesh plate 57 and the reciprocating oscillating movable mesh plate 58; the mixed fluid material is output to external equipment through the discharge port 42, forming liposomes, such as... Figure 13 As shown.

[0052] The parts not covered in this technical solution can be implemented using existing technologies.

[0053] The foregoing has shown and described the basic principles, main features, and characteristics of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the invention as claimed. The scope of protection of this invention includes the appended claims and their equivalents.

Claims

1. A microreactor mixer, characterized in that: It includes a feeding plate (1), a distributing plate (2) and a mixing plate (3). The feeding plate (1), the distributing plate (2) and the mixing plate (3) are spliced ​​and fixed from bottom to top to form an integral structure. The feeding plate (1) is used to convey materials to the distributing plate (2). The distributing plate (2) divides the different materials conveyed by the feeding plate (1) into flat fluids that are spaced apart and distributed in a cross pattern. The mixing plate (3) mixes the materials separated in the distributing plate (2). It also includes a discharge plate (4), which is located above the mixing plate (3). The lower end of the discharge plate (4) is provided with a first groove (41), and a discharge hole (42) is provided on one side of the discharge plate (4). The discharge hole (42) extends to communicate with the first groove (41) to discharge the mixture in the first groove (41). A bracket (5) is fixedly connected in the discharge hole (42), and a first rotating shaft (51) is rotatably connected in the middle of the bracket (5). A spiral blade (52) is fixedly connected on the first rotating shaft (51). One end of the first rotating shaft (51) extends into the first groove (41) and is fixedly connected to a first gear (53). A second gear (54) is rotatably connected to the side wall of the first groove (41). The first gear (53) and the second gear (54) are driven by gear meshing. A pin (55) is fixedly connected to the end of the second gear (54) at an eccentric position. A stop (56) is fixedly connected to the side wall of the first groove (41). A fixed mesh plate (57) is fixedly connected inside the first groove (41). A fixed mesh plate (57) is located below the stop block (56), and a movable mesh plate (58) is provided above the fixed mesh plate (57). The movable mesh plate (58) is slidably connected between the fixed mesh plate (57) and the stop block (56). A drive block (59) is fixedly connected to the upper end of the movable mesh plate (58). A sliding groove (591) arranged vertically is provided on the drive block (59). The pin (55) is inserted in the sliding groove (591). The second gear (54) rotates to make the drive block (59) swing back and forth.

2. The microreactor mixer according to claim 1, characterized in that: The side of the feeding plate (1) is provided with a first feeding hole (11) and a second feeding hole (12) arranged in parallel. The upper surface of the feeding plate (1) is provided with a first vertical feeding channel (13) and a second vertical feeding channel (14) arranged in a row. The first vertical feeding channel (13) is connected to the first feeding hole (11), and the second vertical feeding channel (14) is connected to the second feeding hole (12). The first vertical feeding channel (13) and the second vertical feeding channel (14) are both elongated and arranged perpendicular to the axis of the first feeding hole. The first vertical feeding channel (13) and the second vertical feeding channel (14) are arranged in multiple rows, and the first vertical feeding channel (13) and the second vertical feeding channel (14) are arranged alternately. The dividing plate (2) is provided with a vertical through-hole. The first material distribution hole (21) and the second material distribution hole (22) are arranged in a row along the length of the first vertical feeding channel (13) and the second material distribution hole (22) are arranged in a row along the length of the second vertical feeding channel (14). The first material distribution hole (21) and the second material distribution hole (22) are arranged in a staggered manner. The mixing plate (3) is provided with a mixing groove (31) that runs vertically through the mixing plate (3). Multiple mixing grooves (31) are arranged in parallel. Each mixing groove (31) is located above the first material distribution hole (21) and the second material distribution hole (22) in the same row so as to mix the materials diverted in the first material distribution hole (21) and the second material distribution hole (22) in the mixing groove (31).

3. A microreactor mixer according to claim 2, characterized in that: The first distributing hole (21) includes a first connecting hole section (211) and a first elongated hole section (212) that are connected. The width of the first elongated hole section (212) is smaller than the width of the first connecting hole section (211). The first connecting hole section (211) is located above the first vertical feeding channel (13). The first elongated hole section (212) is located on the upper surface of the feeding plate (1), and the lower part of the first elongated hole section (212) is blocked by the upper surface of the feeding plate (1). The second distributing hole (22) includes a connecting hole section (211) and a first connecting hole section (212). The second connecting hole section (221) and the second elongated hole section (222) are provided. The width of the second elongated hole section (222) is smaller than the width of the second connecting hole section (221). The second connecting hole section (221) is located above the second vertical feed channel (14). The second elongated hole section (222) is located on the upper surface of the feed plate (1) and the lower part of the second elongated hole section (222) is blocked by the upper surface of the feed plate (1). The first elongated hole section (212) and the second elongated hole section (222) are arranged parallel to each other.

4. A microreactor mixer according to claim 3, characterized in that: The first material distribution hole (21) is arranged perpendicularly to the cross section of the first vertical feeding channel (13); the second material distribution hole (22) is arranged perpendicularly to the cross section of the second vertical feeding channel (14).

5. A microreactor mixer according to claim 3, characterized in that: The opening of the first groove (41) faces downward and covers the upper port of the mixing tank (31) to concentrate the mixed materials in the mixing tank (31) for output.

6. A microreactor mixer according to claim 3, characterized in that: The upper surfaces of the feed plate (1), the distribution plate (2) and the mixing plate (3) are provided with annular sealing grooves (6), and sealing rings are provided in the annular sealing grooves (6).

7. A mixing method using a microreactor mixer, employing the microreactor mixer according to any one of claims 3-6, characterized in that: Follow these steps: Step 1: The two different fluid materials are respectively conveyed to the first feed hole (11) and the second feed hole (12) through the conveying pipe; Step 2: The fluid material in the first feed hole (11) is diverted through the first vertical feed channel (13) and enters the first distribution hole (21), and is diverted through the first distribution hole (212) into the mixing tank (31); The fluid material in the second feed hole (12) is diverted through the second vertical feed channel (14) and enters the second distribution hole (22). It is then diverted through the second distribution hole (22) and enters the mixing tank (31) from the second elongated hole section (222). The two dispersed fluid materials are mixed in the mixing tank (31). Step 3: After the materials in the mixing tank (31) are mixed, they enter the first groove (41) and are concentrated. They are further mixed and reacted by the fixed mesh plate (57) and the reciprocating moving mesh plate (58). The mixed fluid material is output to the external equipment through the discharge hole (42).

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