A slow-release metal ion phosphate antibacterial glass and a method for preparing the same

Abstract

The application relates to a slow-release metal ion phosphate antibacterial glass and a preparation method thereof. The antibacterial glass is prepared from the following powders according to percentage by weight: 1-10% of a copper compound, 0.2-2% of an iron compound, 0-5% of an aluminum compound, 1-10% of a zinc compound, 0.5-5% of a boron compound, 2-4% of a silver compound, 10-30% of a sodium compound, 35-70% of a calcium compound, and at least one compound in the powders is a phosphate or an oxide of phosphorus; the preparation method comprises the following steps: mixing the powders, stirring the mixed powders at a speed of 500-1000 revolutions per minute for 10-20 minutes, heating the stirred powders, keeping the temperature at 900-1150 DEG C for 0.5-2 hours to obtain a melt, pouring the melt into a mold, and cooling and shaping to obtain the antibacterial glass. The antibacterial glass can exert excellent bacteriostatic effect by slowly releasing silver ions and zinc ions, and the appearance does not change during use, so that the problem of blackening of the existing products in a humid environment is solved.

Description

Technical Field

[0001] This invention relates to the field of antibacterial materials technology, and in particular to a slow-release metal ion phosphate antibacterial glass and its preparation method. Background Technology

[0002] As people's living standards continue to improve, electrical appliances are enriching their daily lives. For example, humidifiers, washing machines, and floor scrubbers have greatly enhanced people's comfort. However, these appliances are in constant contact with water or water vapor, creating an ideal environment for bacterial growth. Currently, to prevent bacterial growth in these appliances, manufacturers typically use high-temperature antibacterial and ultraviolet light antibacterial technologies for disinfection. This process requires a dedicated disinfection and control system. Conventional water disinfection primarily uses chlorine-based disinfectants, which not only require a disinfection and antibacterial agent system and control system, but also because chlorine-based disinfectants themselves are corrosive and can have adverse effects on humans, equipment, and the environment.

[0003] To address the shortcomings of the aforementioned technologies, current research involves introducing metal ions for antibacterial and antimicrobial effects. This involves loading metal ions onto glass, which then continuously releases these ions upon contact with water, achieving both antibacterial and antimicrobial properties. Currently, some domestic appliance manufacturers use silver-impregnated glass particles for antibacterial treatment of their appliances. The production of these glass particles is primarily based in Japan, and their high import price deters many small appliance companies. Although a few domestic companies have begun researching and producing antibacterial and antimicrobial glass particles in recent years, certain production defects exist. Problems exist in both domestic and international antibacterial (antimicrobial) glasses; for example, if the surface is wet and the glass is not fully immersed in water for a day, the particles may turn black. Summary of the Invention

[0004] The purpose of this invention is to overcome the blackening problem of existing antibacterial glass during immersion use, and to provide a slow-release metal ion phosphate antibacterial glass and its preparation method. The inventors believe that the blackening of antibacterial glass during immersion is related to the release rate of silver ions. When the silver content in the antibacterial glass is high, the release of silver ions is too rapid, easily leading to blackening. This invention regulates the release rate of silver ions using sodium and calcium compounds, while simultaneously incorporating the slow release of zinc ions, thus solving the blackening problem of antibacterial glass during immersion.

[0005] Furthermore, the formulation and preparation method of antibacterial glass are closely related. Under the formulation system of this invention, it is necessary to control the appropriate material mixing rate, mixing time and sintering temperature to ensure uniform mixing effect, while avoiding problems such as overheating, wetting and mottling of the mixture.

[0006] The specific plan is as follows:

[0007] A slow-release metal ion phosphate antibacterial glass is prepared by weight percentage from the following powders: 1-10% copper compound, 0.2-2% iron compound, 0-5% aluminum compound, 1-10% zinc compound, 0.5-5% boron compound, 2-4% silver compound, 10-30% sodium compound, and 35-70% calcium compound, wherein at least one compound in the powder is a phosphate or an oxide of phosphorus;

[0008] The preparation method includes: mixing the powder, stirring at a speed of 500-1000 rpm for 10-20 minutes, heating the stirred powder, holding it at 900-1150℃ for 0.5-2 hours to obtain a melt, pouring the melt into a mold, and cooling to form antibacterial glass.

[0009] Furthermore, the weight percentage of each raw material in the powder is as follows:

[0010] Copper compounds 1-4%, iron compounds 0.2-2%, aluminum compounds 0-5%, zinc compounds 1-10%, boron compounds 0.5-5%, silver compounds 2-4%, sodium compounds 10-30%, calcium compounds 35-70%; or,

[0011] Copper compounds 1-4%, iron compounds 0.5-2%, aluminum compounds 0-5%, zinc compounds 1-10%, boron compounds 0.5-5%, silver compounds 2-4%, sodium compounds 10-30%, calcium compounds 35-70%; or,

[0012] Copper compounds 1-4%, iron compounds 0.5-2%, aluminum compounds 0.1-1%, zinc compounds 1-10%, boron compounds 0.5-5%, silver compounds 2-4%, sodium compounds 10-30%, calcium compounds 35-70%; or,

[0013] Copper compounds 1-4%, iron compounds 0.5-2%, aluminum compounds 0.1-1%, zinc compounds 2-5%, boron compounds 0.5-5%, silver compounds 2-4%, sodium compounds 10-30%, calcium compounds 35-70%; or,

[0014] Copper compounds 1-4%, iron compounds 0.5-2%, aluminum compounds 0.1-1%, zinc compounds 2-5%, boron compounds 1-3%, silver compounds 2-4%, sodium compounds 10-30%, and calcium compounds 35-70%.

[0015] Furthermore, the weight percentages of the raw materials in the powder are: copper compound 1-10%, iron compound 0.2-2%, aluminum compound 0-5%, zinc compound 1-10%, boron compound 0.5-5%, silver compound 2-4%, sodium compound 15-30%, and calcium compound 35-65%; or,

[0016] Copper compounds 1-10%, iron compounds 0.2-2%, aluminum compounds 0-5%, zinc compounds 1-10%, boron compounds 0.5-5%, silver compounds 2-4%, sodium compounds 10-25%, calcium compounds 40-70%; or,

[0017] Copper compounds 1-10%, iron compounds 0.2-2%, aluminum compounds 0-5%, zinc compounds 1-10%, boron compounds 0.5-5%, silver compounds 2-4%, sodium compounds 18-25%, calcium compounds 60-70%; or,

[0018] Copper compounds 1-4%, iron compounds 0.5-2%, aluminum compounds 0.1-1%, zinc compounds 2-5%, boron compounds 1-3%, silver compounds 2-4%, sodium compounds 18-25%, and calcium compounds 60-70%.

[0019] Furthermore, the copper compound is one or a combination of copper sulfate, copper oxide, cuprous oxide, copper phosphate, and basic copper carbonate; the iron compound is one or a combination of iron oxide, iron(III) oxide, ferrous oxide, and ferric sulfate; the aluminum compound is one or a combination of aluminum oxide, aluminum phosphate, aluminum metaphosphate, and aluminum chloride; the zinc compound is one or a combination of zinc oxide, zinc sulfate, zinc chloride, and zinc sulfide; the boron compound is one or a combination of boron oxide, boric acid, sodium borate, and sodium metaborate; the silver compound is one or a combination of silver oxide, silver nitrate, silver sulfate, and silver chloride; the sodium compound is one or a combination of sodium oxide, sodium carbonate, sodium dihydrogen phosphate, and sodium hexametaphosphate; and the calcium compound is one or a combination of calcium oxide, calcium carbonate, calcium dihydrogen phosphate, and calcium sulfate.

[0020] Further, it is prepared by weight percentage from the following powders: copper sulfate 1-3%, iron oxide 0.5-2%, aluminum oxide 0.1-1%, zinc oxide 2-5%, boric acid 1-3%, silver nitrate 2-4%, sodium hexametaphosphate 3-5%, sodium dihydrogen phosphate 15-20%, and calcium dihydrogen phosphate 60-70%.

[0021] Furthermore, when the slow-release metal ion phosphate antibacterial glass is immersed in water, the release rate of silver ions is 0.018-0.026 mg / (g·L·24Hrs·30℃), and the release rate of zinc ions is 0.015-0.025 mg / (g·L·24Hrs·30℃).

[0022] Furthermore, the slow-release metal ion phosphate antibacterial glass exhibits a sterilization rate of ≥99% against Escherichia coli, Staphylococcus aureus, and Candida albicans.

[0023] Further, the process includes the following steps: mixing the powder in proportion, stirring at a speed of 500-1000 rpm for 10-20 minutes, heating the stirred powder, and holding it at 900-1150℃ for 0.5-2 hours to obtain a melt, pouring the melt into a mold, and cooling it to form antibacterial glass.

[0024] Furthermore, the stirring speed is 700-900 rpm, the heating rate is 8-15℃ / min, and the holding temperature is 1000-1150℃.

[0025] This invention also protects the application of the slow-release metal ion phosphate antibacterial glass in the field of antibacterial.

[0026] Beneficial effects: The slow-release metal ion phosphate antibacterial glass provided by this invention controls the content of sodium compounds, calcium compounds and silver compounds in the powder, so that the silver content of the antibacterial glass is kept at a low level, while the release rate meets the antibacterial requirements. More importantly, it avoids the blackening of the antibacterial glass during use, thus solving the problem of product application.

[0027] This invention utilizes a mold to prepare hemispherical antibacterial glass beads, each with a surface area of ​​approximately 2.1 cm². 2 -2.6cm 2 Each bead weighs approximately 0.8g-1.0g, and the resulting antibacterial glass beads have a specific surface area of ​​approximately 2.1cm². 2 / g-3.3cm 2 / g, the product quality is stable and the uniformity meets the requirements of industrial applications.

[0028] The slow-release metal ion phosphate antibacterial glass of this invention exerts a significant antibacterial effect by releasing antibacterial ions such as silver ions and zinc ions. Its sterilization rate against Escherichia coli, Staphylococcus aureus, and Candida albicans is greater than or equal to 99%, which can meet the sterilization requirements of electrical appliances such as air purifiers, humidifiers, and refrigerators. Moreover, the antibacterial glass has a stable appearance during use and has excellent market development prospects. Attached Figure Description

[0029] To more clearly illustrate the technical solution of the present invention, the accompanying drawings will be briefly described below. Obviously, the drawings described below only relate to some embodiments of the present invention and are not intended to limit the present invention.

[0030] Figure 1 This is a sample photograph provided in one embodiment of the present invention;

[0031] Figure 2 This is a graph showing the test results of metal ion dissolution according to an embodiment of the present invention;

[0032] Figure 3This is a photograph of a Staphylococcus aureus inhibition zone provided in one embodiment of the present invention;

[0033] Figure 4 This is a photograph of an Escherichia coli inhibition zone provided in one embodiment of the present invention. Detailed Implementation

[0034] Preferred embodiments of the present invention will now be described in more detail. While preferred embodiments of the present invention are described below, it should be understood that the invention can be implemented in various forms and should not be limited to the embodiments set forth herein. Where specific techniques or conditions are not specified in the embodiments, they are performed in accordance with techniques or conditions described in the literature in the art or according to the product instructions. Reagents or instruments used, unless otherwise specified, are all commercially available conventional products. In the following embodiments, unless otherwise explicitly stated, "%" refers to weight percentage and "parts" refers to parts by weight.

[0035] The following testing methods are included:

[0036] Basic release test: Take 10g of the prepared glass beads and place them in 1L of pure water. After standing in a constant temperature chamber at 30℃ for 24h, measure the concentration of silver and zinc ions in the solution as M, and further convert it to the release amount per gram as C. The unit is mg / (g·L·24Hrs·30℃). This value is the basic release amount.

[0037] To test the amount of silver ions dissolved after 7 days, the specific implementation plan is as follows: remove the basic test glass particles, rinse the surface with pure water 5 times, then soak them continuously in new pure water for 6 days, then remove them again, rinse the surface with pure water 5 times, and then soak them in new pure water for 24 hours. Test the amount of silver and zinc ions released after 7 days.

[0038] To test the amount of silver ions dissolved after 21 days, the glass particles tested after 7 days were removed, the surface was rinsed 5 times with pure water, and then soaked continuously in new pure water for 13 days. After that, they were removed, the surface was rinsed 5 times with pure water, and then soaked in new pure water for 24 hours. The amount of silver and zinc ions released after 21 days was then tested.

[0039] Example 1:

[0040] Slow-release metal ion phosphate antibacterial glass was prepared, yielding the following powder:

[0041] 1 part copper sulfate, 2 parts ferric sulfate, 0.2 parts aluminum oxide, 2.2 parts zinc oxide, 0.5 parts boric acid, 2.4 parts silver nitrate, 36.7 parts sodium dihydrogen phosphate, and 55 parts calcium dihydrogen phosphate.

[0042] The above materials are stirred in a high-speed mixer at 800 rpm for 10-20 minutes. The stirred powder is then placed in a crucible and heated to 1000-1150°C at a rate of 8-15°C. The mixture is held at this temperature for 1 hour to obtain a melt.

[0043] The molten material was directly poured into a mold and cooled under air cooling conditions to form the antibacterial glass. In this embodiment, a hemispherical mold with a radius of 0.5 cm was used. After the molten material cooled and formed, irregular burrs were removed to obtain hemispherical glass beads.

[0044] It should be noted that the present invention does not limit the shape of the mold. The molten liquid prepared according to the formula in the present invention, and the different shapes formed by different molds, are all protected by the patent of the present invention.

[0045] Example 2:

[0046] The method for preparing sustained-release metal ion phosphate antibacterial glass is the same as in Example 1, except that the powder is different, as follows:

[0047] 2 parts copper oxide, 0.5 parts iron oxide, 0.1 parts aluminum sulfate, 3.4 parts zinc oxide, 1 part boric acid, 3 parts silver nitrate, 30 parts sodium phosphate, and 60 parts calcium phosphate.

[0048] Example 3:

[0049] The method for preparing sustained-release metal ion phosphate antibacterial glass is the same as in Example 1, except that the powder is different, as follows:

[0050] Copper sulfate 6 parts, iron oxide 0.2 parts, aluminum phosphate 0.1 parts, zinc oxide 4 parts, boric acid 3.7 parts, silver nitrate 3.5 parts, sodium carbonate 15.5 parts, calcium dihydrogen phosphate 67 parts.

[0051] Example 4:

[0052] The method for preparing sustained-release metal ion phosphate antibacterial glass is the same as in Example 1, except that the powder is different, as follows:

[0053] 10 parts basic copper carbonate, 1 part ferrous oxide, 1 part aluminum oxide, 4 parts zinc oxide, 5 parts boric acid, 4 parts silver sulfate, 25 parts sodium dihydrogen phosphate, and 50 parts calcium dihydrogen phosphate.

[0054] Example 5:

[0055] The method for preparing sustained-release metal ion phosphate antibacterial glass is the same as in Example 1, except that the powder is different, as follows:

[0056] Copper sulfate 4 parts, iron oxide 2 parts, aluminum oxide 5 parts, zinc chloride 4 parts, boric acid 5 parts, silver oxide 2.4 parts, sodium hexametaphosphate 23.5 parts, calcium phosphate 53 parts.

[0057] Example 6:

[0058] The method for preparing sustained-release metal ion phosphate antibacterial glass is the same as in Example 1, except that the powder is different, as follows: 1.9 parts copper sulfate, 0.8 parts iron oxide, 0.3 parts aluminum oxide, 3 parts zinc oxide, 1.2 parts boron oxide, 4 parts sodium hexametaphosphate, 3.2 parts silver nitrate, 18 parts sodium phosphate, and 67.6 parts calcium phosphate.

[0059] Example 7:

[0060] The method for preparing sustained-release metal ion phosphate antibacterial glass is the same as in Example 1, except that the powder is different, as follows:

[0061] 2 parts copper oxide, 1.5 parts iron oxide, 4.6 parts aluminum metaphosphate, 4.7 parts zinc oxide, 2.2 parts boric acid, 6 parts sodium hexametaphosphate, 2.1 parts silver oxide, 19.7 parts sodium phosphate, and 57.2 parts calcium phosphate.

[0062] Comparative Example 1:

[0063] The method for preparing sustained-release metal ion phosphate antibacterial glass is the same as in Example 1, except that the powder is different, as follows:

[0064] Copper sulfate 1.9 parts, iron oxide 0.8 parts, aluminum oxide 0.3 parts, boric acid 1.2 parts, sodium hexametaphosphate 4 parts, silver oxide 6.2 parts, sodium dihydrogen phosphate 35 parts, calcium dihydrogen phosphate 50.6 parts.

[0065] Comparative Example 2:

[0066] The method for preparing sustained-release metal ion phosphate antibacterial glass is the same as in Example 1, except that the powder is different, as follows:

[0067] Copper sulfate 1.9 parts, iron oxide 0.8 parts, aluminum oxide 0.3 parts, zinc oxide 3 parts, boric acid 1.2 parts, sodium hexametaphosphate 1 part, silver nitrate 3.2 parts, sodium dihydrogen phosphate 1 part, calcium dihydrogen phosphate 84.6 parts.

[0068] Comparative Example 3:

[0069] The preparation of slow-release metal ion phosphate antibacterial glass follows the same raw material dosage and method as in Example 1, except that the raw materials are mixed and stirred at 800 rpm for 4 minutes.

[0070] Comparative Example 4:

[0071] The preparation of slow-release metal ion phosphate antibacterial glass follows the same raw material dosage and method as in Example 1, except that the stirred powder is placed in a crucible and heated to 850°C at a rate of 8-10°C and held at that temperature for 1 hour.

[0072] Performance testing

[0073] (1) Samples from the examples and comparative examples were taken and tested for basic release amount, metal ion dissolution amount, etc. The results are shown in Table 1.

[0074] Table 1. Results of Ion Release Test on Antibacterial Glass

[0075]

[0076] As can be seen from Table 1, the antibacterial glass prepared by this invention has a green and transparent appearance, such as... Figure 1 As shown, the blackening of antibacterial glass upon immersion in water is related to the release rate of silver ions. When the release rate of silver ions is 0.0180-0.026 mg / (g·L·24Hrs·30℃) and the release rate of zinc ions is 0.0150-0.023 mg / (g·L·24Hrs·30℃), the appearance of the antibacterial glass remains essentially unchanged. In Comparative Example 1, the release rate of silver ions was too high, resulting in blackening upon immersion. In Comparative Example 2, the release rate of silver ions was too low, failing to meet the requirements for antibacterial effect.

[0077] In the preparation method of slow-release metal ion phosphate antibacterial glass, it is suitable to stir each powder material in a high-speed stirring device at a speed of 500-1000 rpm for 10-20 minutes. The stirring time should not be too short, otherwise uneven stirring will occur, affecting the component distribution during sintering and causing mottled phenomena after sintering (as in Comparative Example 3). If the stirring time is too long, such as more than half an hour, the powder will become hot and tend to become wet, increasing the difficulty of subsequent operations; if the stirring time is extended to 3 hours, the powder will become liquid, making it difficult to proceed to the next step. Comparative Example 4 shows that when the stirred powder is placed in a crucible for sintering, if the sintering temperature is below 900℃, the sintering will be incomplete, and mottled phenomena will occur.

[0078] (2) Take the sample prepared in Example 6 and measure the metal ion dissolution rate after 7 days and 21 days, such as... Figure 2 As shown, the release rates of silver and zinc ions in the sample are relatively stable, exhibiting a sustained-release effect.

[0079] (3) Take the samples prepared in Example 6 and Example 7 and test their antibacterial properties. The test is conducted using Appendix E of GB / T23332-2018 with 2g / 500ml water.

[0080] like Figure 3 and Figure 4 As shown, the antibacterial glass has a significant antibacterial effect. The antibacterial ring was measured, and the results are shown in Table 2. The sterilization rate was further calculated, and the results are shown in Table 3.

[0081] Table 2 Results of the antibacterial ring test

[0082]

[0083] Table 3. Results of sterilization rate test for sample in Example 6

[0084]

[0085]

[0086] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0087] It should also be noted that the various specific technical features described in the above embodiments can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

[0088] Furthermore, various different embodiments of the present invention can be combined in any way, as long as they do not violate the spirit of the present invention, they should also be regarded as the content disclosed by the present invention.

Claims

1. A slow-releasing metal ion phosphate antibacterial glass, characterized by: According to the weight percentage, the following powders are prepared: copper compound 1-10%, iron compound 0.2-2%, aluminum compound 0-5%, zinc compound 1-10%, boron compound 0.5-5%, silver compound 2-4%, sodium compound 10-30%, calcium compound 35-70%, and at least one compound in the powders is phosphate or phosphorus oxide; the sodium compound is one or a combination of sodium oxide, sodium carbonate and sodium hexametaphosphate; The calcium compound is one or a combination of calcium carbonate, calcium dihydrogen phosphate and calcium sulfate; The preparation method comprises the following steps: mixing the powders, stirring at a speed of 500-1000 rpm for 10-20 minutes, heating the stirred powders, and keeping the temperature at 900-1150℃ for 0.5-2 hours to obtain a melt, pouring the melt into a mold, and cooling to form an antibacterial glass; the slow-release metal ion phosphate antibacterial glass has a silver ion release speed of 0.018-0.026 mg / (g·L·24Hrs·30℃) and a zinc ion release speed of 0.015-0.025 mg / (g·L·24Hrs·30℃) when immersed in water, and the antibacterial glass has a green transparent appearance and the appearance of the antibacterial glass does not change substantially when immersed in water.

2. The slow-releasing metal ion phosphate antibacterial glass according to claim 1, wherein: The weight percentage of each raw material in the powders is: Copper compound 1-4%, iron compound 0.2-2%, aluminum compound 0-5%, zinc compound 1-10%, boron compound 0.5-5%, silver compound 2-4%, sodium compound 10-30%, and calcium compound 35-70%; or Copper compound 1-4%, iron compound 0.2-2%, aluminum compound 0-5%, zinc compound 1-10%, boron compound 0.5-5%, silver compound 2-4%, sodium compound 10-30%, and calcium compound 35-70%; or Copper compound 1-4%, iron compound 0.2-2%, aluminum compound 0-5%, zinc compound 1-10%, boron compound 0.5-5%, silver compound 2-4%, sodium compound 10-30%, and calcium compound 35-70%; or Copper compound 1-4%, iron compound 0.2-2%, aluminum compound 0-5%, zinc compound 1-10%, boron compound 0.5-5%, silver compound 2-4%, sodium compound 10-30%, and calcium compound 35-70%; or Copper compound 1-4%, iron compound 0.2-2%, aluminum compound 0-5%, zinc compound 1-10%, boron compound 0.5-5%, silver compound 2-4%, sodium compound 10-30%, and calcium compound 35-70%; or 3. The slow-releasing metal ion phosphate-antibacterial glass according to claim 1, wherein: The weight percentage of each raw material in the powders is: copper compound 1-10%, iron compound 0.2-2%, aluminum compound 0-5%, zinc compound 1-10%, boron compound 0.5-5%, silver compound 2-4%, sodium compound 15-30%, and calcium compound 35-65%; or Copper compound 1-10%, iron compound 0.2-2%, aluminum compound 0-5%, zinc compound 1-10%, boron compound 0.5-5%, silver compound 2-4%, sodium compound 10-25%, calcium compound 40-70%; or, Copper compound 1-10%, iron compound 0.2-2%, aluminum compound 0-5%, zinc compound 1-10%, boron compound 0.5-5%, silver compound 2-4%, sodium compound 18-25%, calcium compound 60-70%; or, Copper compound 1-4%, iron compound 0.5-2%, aluminum compound 0.1-1%, zinc compound 2-5%, boron compound 1-3%, silver compound 2-4%, sodium compound 18-25%, calcium compound 60-70%.

4. The slow-releasing metal ion phosphate-antibacterial glass according to any one of claims 1 to 3, characterized in that: The copper compound is one or combination of copper sulfate, copper oxide, cuprous oxide, copper phosphate and basic copper carbonate; the iron compound is one or combination of iron oxide, magnetite, ferrous oxide, iron sulfate; the aluminum compound is one or combination of aluminum oxide, aluminum phosphate, aluminum metaphosphate and aluminum chloride; the zinc compound is one or combination of zinc oxide, zinc sulfate, zinc chloride and zinc sulfide; the boron compound is one or combination of boron oxide, boric acid, sodium borate and sodium metaborate; the silver compound is one or combination of silver oxide, silver nitrate, silver sulfate and silver chloride.

5. The slow-releasing metal ion phosphate-antibacterial glass according to claim 4, wherein: According to weight percentage, the following powders are prepared: copper sulfate 1-3%, iron oxide 0.5-2%, aluminum oxide 0.1-1%, zinc oxide 2-5%, boric acid 1-3%, silver nitrate 2-4%, sodium hexametaphosphate 3-5%, sodium dihydrogen phosphate 15-20%, calcium dihydrogen phosphate 60-70%.

6. The slow-releasing metal ion phosphate-antibacterial glass according to claim 1, wherein: The slow-release metal ion phosphate antibacterial glass has a sterilization rate of greater than or equal to 99% for E. coli, Staphylococcus aureus and Candida albicans.

7. A method of making the slow-releasing metal ion phosphate-antimicrobial glass according to any one of claims 1 to 6, characterized in that: The method comprises the following steps: mixing the powders in proportion, stirring the mixed powders at a speed of 500-1000 rpm for 10-20 minutes, heating the stirred powders, and keeping the temperature at 900-1150 °C for 0.5-2 h to obtain a melt, pouring the melt into a mold, and cooling and shaping to obtain the antibacterial glass.

8. The method for preparing the slow-release metal ion phosphate antibacterial glass according to claim 7, characterized in that: The stirring speed is 700-900 rpm, the heating rate is 8-15 °C / min, and the temperature keeping temperature is 1000-1150 °C.

9. Use of the slow-release metal ion phosphate antibacterial glass according to any one of claims 1-6 in the field of antibacterial applications.

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