Blood purification device

Abstract

A blood purification apparatus is provided which is configured to use a B medicament solution used in a blood purification treatment process also as an alkaline medicament in a de-lipidation cleaning process, thereby achieving good performance of the de-lipidation cleaning by removing carbon dioxide generated in the de-lipidation cleaning process. The blood purification apparatus includes a line section, a double pump (1), and a control unit (13). The line section includes a dialysate introduction line (L1) and a drain discharge line (L2). The control unit (13) is configured to execute a blood purification treatment process and a de-lipidation cleaning process. The blood purification treatment process is executed when a blood purification treatment in which dialysate is delivered to a dialyzer (C) is executed. The dialysate is prepared by mixing an A medicament solution and a B medicament solution of the introduction line section and diluting the A medicament solution and the B medicament solution to a predetermined concentration. The de-lipidation cleaning process is executed when a de-lipidation cleaning in which grease in the line section is removed by flowing a bicarbonate solution through the line section is executed. The bicarbonate solution is obtained by heating the B medicament solution of the introduction line section. The control unit (13) discharges carbon dioxide to the outside of the line section in the de-lipidation cleaning process. The carbon dioxide is generated when the bicarbonate solution is caused to flow.

Description

Technical Field

[0001] This invention relates to a blood purification device that purifies a patient's blood by circulating blood outside the body through a blood purifier and a blood circuit. Background Technology

[0002] A typical dialysis device, intended for blood purification purposes such as dialysis treatment, includes a tubing section and a delivery unit. The tubing section includes a dialysate inlet line through which dialysate is introduced into the blood purifier; and a drain line through which drained fluid is discharged from the blood purifier. The delivery unit is configured to deliver dialysate and drained fluid within the tubing section. Additionally, a blood circuit for circulating the patient's blood outside the body is connected to the blood purifier. Dialysis treatment (blood purification therapy) is performed using the blood purifier while the patient's blood is circulated outside the body within the blood circuit.

[0003] Generally, such blood purification devices maintain cleanliness over a long period through a degreasing and cleaning process, in which grease is washed away, for example, by allowing an alkaline agent such as sodium carbonate or sodium hypochlorite to flow through a relevant flow path included in the pipeline. In the prior art, a solution of reagent B used to prepare the dialysate is heated to generate a sodium carbonate solution, which is then used as the alkaline agent flowing through the pipeline in the degreasing and cleaning process (see, for example, Patent Document 1).

[0004] In this technology, if the sodium carbonate solution obtained by heating the B-type reagent solution used to prepare dialysate in dialysis treatment is also used as the alkaline reagent in the degreasing and cleaning process, then a portion of the B-type reagent solution remaining in dialysis treatment can be reused. Therefore, the cost of the reagents is reduced. Furthermore, reducing the number of different reagent types used in the degreasing and cleaning process reduces the labor required for management.

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: Japanese Patent Application Publication No. 2018-118033 Summary of the Invention

[0008] The technical problem to be solved by the present invention

[0009] In the aforementioned known blood purification apparatus, although the B-type reagent solution used in dialysis treatment (blood purification treatment process) can be reused as an alkaline reagent (sodium carbonate solution) in the degreasing and cleaning process, carbon dioxide (CO2) generated by heating the B-type reagent solution may accumulate in the pipeline and hinder the good performance of the degreasing and cleaning process. The carbon dioxide generated by heating the B-type reagent solution can be removed beforehand by degassing. Even in this case, carbon dioxide may still be generated during the degreasing and cleaning process and accumulate in the pipeline.

[0010] The present invention was made in view of the above circumstances, and its object is to provide a blood purification device that uses the B agent solution used in the blood purification treatment process as an alkaline agent in the degreasing cleaning process, thereby achieving good degreasing cleaning performance by removing the carbon dioxide generated in the degreasing cleaning process.

[0011] Solution to the problem

[0012] A blood purification apparatus according to an embodiment of the present invention is configured to purify a patient's blood by circulating blood extracorporeally through a blood purifier and a blood circuit. The apparatus includes: a tubing section comprising a dialysate inlet tubing for introducing dialysate into the blood purifier and a drain tubing for discharging wastewater from the blood purifier; a delivery unit configured to deliver fluid in the tubing section; and a control unit configured to perform a blood purification treatment step and a degreasing cleaning step by controlling the delivery unit. The blood purification treatment step is performed when dialysate is delivered to the blood purifier. The dialysate is prepared by mixing a drug solution A and a drug solution B in the inlet tubing section and diluting the drug solutions A and B to a predetermined concentration. The degreasing cleaning step is performed when degreasing cleaning is performed, in which grease in the tubing section is removed by flowing a bicarbonate solution through the tubing section. A bicarbonate solution is obtained by heating the drug solution B in the inlet tubing section. The control unit discharges carbon dioxide to the outside of the tubing section during the degreasing cleaning step. Carbon dioxide is generated when the bicarbonate solution is flowed.

[0013] Invention Effects

[0014] According to this embodiment, in the degreasing and cleaning process, the carbon dioxide generated when the bicarbonate solution flows is discharged to the outside of the pipeline. Therefore, by using the B-type drug solution used in the blood purification treatment process as an alkaline agent in the degreasing and cleaning process, good degreasing and cleaning performance can be achieved by removing the carbon dioxide generated in the degreasing and cleaning process. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of a blood purification device according to an embodiment of the present invention.

[0016] Figure 2 This is a schematic diagram illustrating the blood purification treatment process performed by a blood purification device.

[0017] Figure 3 This is a schematic diagram illustrating the bicarbonate solution generation process performed by a blood purification device.

[0018] Figure 4 This is a schematic diagram illustrating the degreasing and cleaning process performed by a blood purification device.

[0019] Figure 5 This is a schematic diagram illustrating the step of removing carbon dioxide during the degreasing and cleaning process in a blood purification device.

[0020] Figure 6 This is a flowchart showing the control sequence executed by the control unit included in the blood purification device. Detailed Implementation

[0021] Embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0022] The blood purification device according to the embodiment is configured to purify the patient's blood by circulating the blood outside the body through a blood purifier and a blood circuit. For example... Figure 1 As shown, the blood purification device includes: a blood circuit K, which includes an arterial blood circuit K1 and a venous blood circuit K2; a dialyzer C, which serves as a blood purifier; a pipeline section, which includes a dialysate inlet pipeline L1 and a dialysate outlet pipeline L2; a dual pump 1, which serves as a delivery unit; and a control unit 13.

[0023] Arterial blood circuit K1 has a connector at its distal end. An arterial puncture needle can be connected to arterial blood circuit K1 via the connector. Arterial blood circuit K1 also includes a peristaltic pump and an arterial air trap chamber at its intermediate position. Venous blood circuit K2 has a connector at its distal end. A venous puncture needle can be connected to venous blood circuit K2 via the connector. Venous blood circuit K2 also includes a venous air trap chamber at its intermediate position.

[0024] The dialyzer C (blood purifier) ​​has a blood inlet C1, a blood outlet C2, a dialysate inlet C3 (the inlet of the dialysate flow path, or dialysate inlet), and a dialysate outlet C4 (the outlet of the dialysate flow path, or dialysate delivery outlet) within its housing. An arterial blood circuit K1 is connected to the blood inlet C1. A venous blood circuit K2 is connected to the blood outlet C2. The dialysate inlet C3 and the dialysate outlet C4 are connected to the dialysate inlet line L1 and the dialysate outlet line L2, respectively.

[0025] Dialyzer C houses multiple hollow fiber membranes (not shown) formed of hollow fibers, serving as blood purification membranes for purifying the blood. The blood purification membranes in dialyzer C define blood flow paths (each extending between a blood inlet C1 and a blood outlet C2) and dialysate flow paths (each extending between a dialysate inlet C3 and a dialysate outlet C4). The hollow fiber membranes constituting the blood purification membranes have multiple tiny pores (micropores) extending from the outer peripheral surface to the inner peripheral surface. Impurities in the blood permeate through the membrane into the dialysate.

[0026] When an arterial puncture needle connected to the distal end of the arterial blood circuit K1 and a venous puncture needle connected to the distal end of the venous blood circuit K2 are used to puncture the patient, the blood pump is activated. The patient's blood flows through the arterial blood circuit K1 and reaches the dialyzer C, where it is purified. The purified blood then flows through the venous blood circuit K2 and returns to the patient. Thus, the patient's blood is purified by the dialyzer C while simultaneously circulating extracorporeally within the blood circuit K.

[0027] The main body of the device includes a pipeline section and a dual pump 1 (delivery unit). The pipeline section includes: a dialysate inlet line L1 through which dialysate is introduced into the dialyzer C; and a drain line L2 through which drain fluid is discharged from the dialyzer C. The dual pump 1 is configured to deliver dialysate and drain fluid within this pipeline section. The dual pump 1 includes: an intake section 1a connected to the dialysate inlet line L1, and a discharge section 1b connected to the drain line L2. That is, the dual pump 1 is positioned between the dialysate inlet line L1 and the drain line L2. When the dual pump 1 is activated, dialysate is introduced into the dialyzer C through the dialysate inlet line L1, and then discharged from the dialyzer C along with waste products and excess water from the blood through the drain line L2. The dual pump 1 can be replaced by any other device (e.g., a device including a so-called balance chamber).

[0028] like Figure 1 As shown, the pipeline section includes a dialysate inlet line L1 and a drain line L2; it also includes bypass lines L3-L5, which are respectively connected to the dialysate inlet line L1 and the drain line L2; a detour line L6, which is detoured to the discharge section 1b of the double pump 1 of the drain line L2; and A-reagent solution inlet line L7 and B-reagent solution inlet line L8, with the dialysate inlet line L1 connected to the A-reagent solution storage tank T1 and the B-reagent solution storage tank T2 respectively through the A-reagent solution inlet line L7 and the B-reagent solution inlet line L8.

[0029] Bypass lines L3 to L5 are equipped with solenoid valves V5-V7 respectively. Solenoid valves V8 and V9 are installed on the A-solution inlet line L7 and the B-solution inlet line L8 respectively. Infusion pumps 8a and 8b are also installed on the A-solution inlet lines L7 and L8 respectively. When infusion pump 8a is started with solenoid valve V8 open, the A-solution inlet tank T1 is introduced into the dialysate inlet line L1 through the A-solution inlet line L7. When infusion pump 8b is started with solenoid valve V9 open, the B-solution inlet tank T2 is introduced into the dialysate inlet line L1 through the B-solution inlet line L8.

[0030] The dialysate inlet line L1 is equipped with solenoid valves V1 and V3, a heat exchanger 3, a heating unit 4, a degassing pump 7, a degasser 5, stirring chambers 9a and 9b, and capture units 10 and 11. The heat exchanger 3 includes a flow path for supplying purified water (RO water) to the dialysate inlet line L1 and a flow path for drained liquid flowing in the drain line L2. Heat exchange occurs between the two flow paths in the heat exchanger 3, with the heat from the drained liquid being transferred to the purified water.

[0031] Heating unit 4 is a heater installed on the dialysate inlet line L1, capable of heating the purified water supplied to the dialysate inlet line L1. Downstream of heating unit 4 ( Figure 1 A temperature sensor t is installed on the right side of the heating unit 4, which is configured to detect the temperature (water temperature) of the purified water heated by the heating unit 4. A throttling orifice 6 is provided downstream of the temperature sensor t. When the deaeration pump 7 is started, the purified water flowing through the throttling orifice 6 is introduced into the deaerator 5.

[0032] The degasser 5 is a chamber connected to the dialysate inlet line L1, and a circulation line L9 (circulation path) is provided at its bottom. The circulation line L9 is connected to a predetermined position upstream of the dialysate inlet line L1 of the degasser 5 (the position between the heat exchanger 3 and the heating unit 4), so that the purified water supplied to the dialysate inlet line L1 can circulate within it. The degasser 5 is also provided with a degassing line N1 at its top. The degassing line N1 extends to the drain line L2, so that the air bubbles collected by the degasser 5 can be discharged to the outside of the pipeline section through the degassing line N1.

[0033] Solution A and Solution B have different compositions for generating dialysate. Specifically, Solution A (Solution A) is a mixed aqueous solution containing sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium acetate, etc. Solution B (Solution B) is an aqueous solution of sodium bicarbonate (NaHCO3). Solution A and Solution B are stored in predetermined amounts in storage tanks T1 and T2, respectively. When infusion pumps 8a and 8b are started, Solution A and Solution B are introduced into dialysate inlet line L1.

[0034] The A and B reagent solutions, introduced into the dialysate inlet line L1 via A reagent solution inlet line L7 and B reagent solution inlet line L8, are mixed and diluted with purified water in stirring chambers 9a and 9b, thereby preparing dialysate of a predetermined concentration. Specifically, while the purified water supplied to the dialysate inlet line L1 circulates in the circulation line L9, the purified water is heated by the heating unit 4 and degassed (air bubbles are removed) by the deaerator 5. The heated and degassed purified water is then mixed with the A and B reagent solutions to obtain dialysate of a predetermined concentration.

[0035] Capture units 10 and 11 are configured to capture air bubbles in the dialysate during a blood purification treatment process, while allowing the dialysate to flow through them. Capture units 10 and 11 include: respective bubble filters 10a and 11a; respective first regions 10b and 11b, located upstream of each bubble filter 10 and 11a and storing the captured air bubbles therein; and respective second regions 10c and 11c, located downstream of each bubble filter 10a and 11a and allowing the received dialysate to flow through them. The first region 10b of capture unit 10 is connected to the drain line L2 via a bypass line L4. The first region 11b of capture unit 11 is connected to the drain line L2 via a bypass line L5.

[0036] The dialysate inlet line L1 is also equipped with hydraulic detectors S1 and S2. Hydraulic detectors S1 and S2 are located downstream (or upstream) of each bubble filter 10a and 11a, and each detector is a sensor capable of detecting hydraulic pressure. During the blood purification treatment process, if either hydraulic detector S1 or S2 detects a predetermined hydraulic pressure change, the corresponding solenoid valves V6 and V7 (switching valves) are opened, thereby allowing air bubbles in the first regions 10b and 11b to be discharged to the outside of the pipeline section through bypass lines L4 and L5 and the drain line L2.

[0037] Solenoid valves V2 and V4, a pressurizing pump P, and a degassing chamber 12 are installed on the drainage line L2. An ultrafiltration pump 2 is installed on the detour line L6 of the drainage section 1b of the detour double pump 1. The ultrafiltration pump 2 is used to remove water (excess water) from the patient's blood flowing through the dialyzer C. Specifically, when the ultrafiltration pump 2 is activated, the amount of drainage L2 discharged through the drainage line becomes greater than the amount of dialysate introduced through the dialysate inlet line L1. Therefore, the amount of water corresponding to this difference is removed from the blood.

[0038] The degassing chamber 12 is a cavity connected to the drain line L2, and its bottom is connected to a predetermined position on the bypass line L6 via a connecting line L6a. The degassing chamber 12 is also connected to the degassing line N2 at its top. The degassing line N2 extends downstream of the drain line L2, allowing air bubbles collected by the degassing chamber 12 to be discharged to the outside of the line section through the degassing line N2. The degassing line N2 is equipped with a solenoid valve V10, allowing it to be opened and closed at any time.

[0039] The control unit 13 is a microcomputer installed in the main body of the device. During blood purification treatment, the control unit 13 is configured to execute the blood purification treatment process, in which dialysate is delivered to the dialyzer C. The dialysate is prepared by mixing drug solution A and drug solution B in the inlet tubing and diluting drug solutions A and B to a predetermined concentration. Specifically, in the blood purification treatment process, such as... Figure 2 As shown, open solenoid valves V8 and V9, start infusion pumps 8a and 8b, and start the dual pump 1 and ultrafiltration pump 2. This introduces the A and B reagent solutions from the dialysate inlet line L1, which are then mixed with purified water to form a dialysate of the predetermined concentration. The resulting dialysate is then delivered to dialyzer C for dialysis treatment to purify and ultrafilter the patient's blood.

[0040] In addition to the blood purification treatment process, the control unit 13 of this embodiment can also perform the following processes by controlling the dual pump 1 and using the heating unit 4 and the degasser 5: a bicarbonate solution generation process, wherein a predetermined amount of bicarbonate solution is generated while carbon dioxide is discharged; and a degreasing cleaning process, which performs degreasing cleaning, wherein grease in the pipeline section is removed by allowing the bicarbonate solution to flow through the pipeline section. The bicarbonate solution is obtained by heating the B agent solution introduced into the pipeline section. The bicarbonate solution generation process is a process of generating an alkaline agent (sodium carbonate solution) from the B agent solution used in the blood purification treatment process. The alkaline agent is used in the degreasing cleaning process, wherein degreasing cleaning is performed by allowing the alkaline agent generated in the bicarbonate solution generation process to flow through the pipeline section.

[0041] More specifically, the bicarbonate solution preparation process is carried out as follows. For example... Figure 3As shown, the distal end of the dialysate inlet line L1 and the distal end of the drain line L2 are connected to each other via coupler D to establish a short circuit. Furthermore, solenoid valves V4, V5, and V9 are opened, while the other solenoid valves are closed. Additionally, the degassing pump 7 and the infusion pump 8b are started. During this process, the dual pump 1, the ultrafiltration pump 2, and other devices are stopped. Thus, the B reagent solution in the B reagent solution storage tank T2 is introduced into the dialysate inlet line L1, heated by the heating unit 4, and circulated in the circulation line L9.

[0042] When the B reagent solution (sodium bicarbonate (NaHCO3)) circulates through the circulation line L9, the B reagent solution is diluted and heated by the heating unit 4 (to approximately 65°C or higher), thereby decomposing into sodium carbonate (Na2CO3), water (H2O), and carbon dioxide (CO2). Therefore, a sodium carbonate solution (bicarbonate solution) is obtained from the B reagent solution as an alkaline reagent used in the degreasing and cleaning process. The carbon dioxide generated by the heating of the B reagent solution by the heating unit 4 is collected by the degasser 5 and discharged to the outside of the pipeline section through the degassing line N1 and the drain line L2.

[0043] In the bicarbonate solution generation process, heating unit 4 heats the B reagent solution introduced into the pipeline, and degasser 5 discharges the carbon dioxide generated by the B reagent solution heated by heating unit 4 to the outside of the pipeline. That is, in the process of circulating the B reagent solution in the circulation pipeline L9, while the B reagent solution heated by heating unit 4 generates sodium carbonate solution (bicarbonate solution), carbon dioxide is discharged by degasser 5.

[0044] In summary, the heating unit 4 and the degasser 5 are used to perform the following steps. In the blood purification treatment step, purified water circulating in the circulation line L9 to prepare dialysate of a predetermined concentration by mixing drug solution A and drug solution B is heated and degassed. Furthermore, in the bicarbonate solution generation step, carbon dioxide is discharged while generating sodium carbonate solution by heating drug solution B. After generating a predetermined amount of sodium carbonate solution and discharging carbon dioxide by using the heating unit 4 and degasser 5 in the bicarbonate solution generation step, the sodium carbonate solution is used in the degreasing and cleaning step.

[0045] This embodiment also employs a storage unit configured to store a predetermined amount of sodium carbonate solution generated by heating the B reagent solution. The storage unit is a flow path within a predetermined section of the pipeline. In this embodiment, the storage unit includes a flow path of the heat exchanger 3 (heat exchanger flow path). The heat exchanger flow path is the section in the dialysate inlet pipeline L1 that exchanges heat with the drain pipeline L2. Specifically, the storage unit is located upstream of the connection between the dialysate inlet pipeline L1 and the B reagent solution inlet pipeline L8. Figure 3The flow path (on the left side of the structure) includes a circulation line L9, a heat exchanger flow path for heat exchanger 3, and a bypass line L3. The storage unit can store the sodium carbonate solution generated during the bicarbonate solution generation process.

[0046] In the degreasing and cleaning process, such as Figure 4 As shown, the distal end of the dialysate inlet line L1 and the distal end of the drain line L2 are coupled together via coupler D. Solenoid valves V1, V2, V5, and V10 are open, while the other solenoid valves are closed. Additionally, the degassing pump 7, the dual pump 1, the ultrafiltration pump 2, and the booster pump P are started. During this process, infusion pumps 8a and 8b are stopped. Furthermore, solenoid valves V5-V7 are open at any time during the degreasing cleaning of bypass lines L3-L5. This causes the sodium carbonate solution stored in the storage section to flow and circulate within the pipeline section, thereby achieving degreasing cleaning.

[0047] The control unit 13 according to this embodiment can execute a control sequence during the degreasing and cleaning process, wherein carbon dioxide generated when the sodium carbonate solution is flowed is discharged to the outside of the pipeline. Specifically, in the degreasing and cleaning process, if a predetermined hydraulic change (in this embodiment, an increase in hydraulic pressure) is detected by the hydraulic detector S1, the control unit 13 discharges the carbon dioxide captured by the bubble filter 10a of the capture unit 10 to the outside of the pipeline.

[0048] More specifically, in the degreasing and cleaning process, if carbon dioxide is captured and accumulates in the first region 10b of the capture section 10, the hydraulic pressure in the second region 10c increases. If the hydraulic pressure detector S1 detects this change in hydraulic pressure, refer to... Figure 5 Solenoid valves V4, V6, and V10 open, while the other solenoid valves close, and the pressurization pump P is activated. During this process, the degassing pump 7, the dual pump 1, the ultrafiltration pump 2, and the infusion pumps 8a and 8b stop. Therefore, the carbon dioxide captured by the bubble filter 10a of the capture section 10 and accumulated in the first region 10b is introduced through the bypass line L4 to the discharge line L2, and discharged to the outside of the pipeline section through the degassing line N2 connected to the degassing chamber 12.

[0049] Now, Figure 6 The flowchart shown describes the control sequence executed by the control unit 13 according to this embodiment.

[0050] First, a preparatory cleaning operation (S1) is performed. Specifically, the distal end of the dialysate inlet line L1 is short-circuited with the distal end of the drain line L2 via a coupler D, and purified water is supplied into the dialysate inlet line L1 and flows through the relevant flow paths included in the line section. As a result, the dialysate in the line section is washed away.

[0051] Next, as Figure 3 As shown, the B reagent solution in the storage tank T2 is introduced into the dialysate inlet line L1 (S2) to perform the bicarbonate solution generation process. In this process, the B reagent solution is circulated in the circulation line L9 and heated by the heating unit 4. Therefore, a sodium carbonate (Na2CO3) solution of a predetermined concentration is generated, while carbon dioxide (CO2) is discharged through the degassing line N1 (S3).

[0052] The resulting sodium carbonate solution is stored in a storage compartment located upstream of the connection between dialysate inlet line L1 and reagent B inlet line L8. Figure 3 The flow path (on the left side of the flow path) includes the circulation line L9, the heat exchanger flow path of the heat exchanger 3, and the bypass line L3. Then, in S4, it is checked whether the injection volume of the B reagent solution has reached the specified value or greater. If it is determined that the injection volume has reached the specified value or greater, the process proceeds to S5, where a degreasing and cleaning process is performed.

[0053] In the degreasing and cleaning process, such as Figure 4 As shown, the dual pump 1 and other related devices are started, thereby circulating the sodium carbonate solution stored in the storage section in the relevant flow path of the pipeline section (S5). In the degreasing cleaning process, the A-solution storage tank T1 and the B-solution storage tank T2 can be separated from the A-solution inlet line L7 and the B-solution inlet line L8. Therefore, the sodium carbonate solution can also flow through the A-solution inlet line L7 and the B-solution inlet line L8 for degreasing cleaning. Regardless of the method, patient-derived proteins can be removed by the cleaning action of the sodium carbonate solution. Therefore, degreasing cleaning of the pipeline section is achieved.

[0054] While circulating the sodium carbonate solution, check for CO2 detection based on changes in hydraulic pressure detected by hydraulic pressure detector S1 (S6). If it is determined that any CO2 has been detected, refer to... Figure 5 The carbon dioxide captured by the bubble filter 10a of the capture section 10 and accumulated in the first region 10b is introduced into the drain line L2 through the bypass line L4, and discharged to the outside of the pipeline section through the degassing line N2 connected to the degassing chamber 12 (S7). That is, during the degreasing and cleaning process, the carbon dioxide generated when the sodium carbonate solution flows is captured and discharged from the pipeline section.

[0055] On the other hand, if no CO2 is detected in S6, the final cleaning operation (S8) is performed. Specifically, purified water is supplied to the dialysate inlet line L1 and flows through the relevant flow paths included in the line. Therefore, the sodium carbonate solution in the line is washed away. Through the above operations, the bicarbonate solution generation process and the degreasing cleaning process are completed. Since the line has been cleaned and disinfected, another round of blood purification treatment is ready to be performed.

[0056] According to this embodiment, in the degreasing and cleaning process, the carbon dioxide generated when the sodium carbonate solution flows is discharged to the outside of the pipeline. Therefore, while using the B-type reagent solution used in the blood purification treatment process as the alkaline agent in the degreasing and cleaning process, good degreasing and cleaning performance is achieved by removing the carbon dioxide generated in the degreasing and cleaning process. In particular, in the degreasing and cleaning process, carbon dioxide is captured by the bubble filter 10a of the capturing unit 10 while the sodium carbonate solution flows. Therefore, carbon dioxide can be reliably captured.

[0057] Furthermore, during the degreasing and cleaning process, if a predetermined hydraulic pressure change is detected by the hydraulic pressure detector S1, the carbon dioxide captured by the bubble filter 10a of the capture unit 10 is discharged to the outside of the pipeline section. Therefore, the captured carbon dioxide is automatically discharged to the outside of the pipeline section. More specifically, if a predetermined hydraulic pressure change is detected by the hydraulic pressure detector S1 during the degreasing and cleaning process, the solenoid valve V6 (switching valve) is opened, allowing the carbon dioxide in the first zone 10b to be discharged to the outside of the pipeline section through the bypass line L4 and the drain line L2. Therefore, the bypass line L4 used in the blood purification treatment process is also used to discharge carbon dioxide to the outside of the pipeline section.

[0058] The embodiments have been described above, but the present invention is not limited thereto. For example, the capturing unit 10 can be replaced by any other device configured to capture and discharge carbon dioxide generated when the sodium carbonate solution is flowed during the degreasing and cleaning process. Specifically, the capturing unit 10 can be any device that is also used in the blood purification treatment process as described in the above embodiments, or it can be a device specifically designed for capturing carbon dioxide that is not used in the blood purification treatment process.

[0059] The above embodiments relate to a case where a sodium carbonate solution, obtained by heating a solution of drug B introduced into the pipeline, is used to degrease and clean the pipeline section. Alternatively, a bicarbonate solution different from the sodium carbonate solution can be used. Furthermore, although the above embodiments relate to single-patient dialysis devices, the present invention is also applicable to other blood purification devices such as multi-patient dialysis devices.

[0060] Industrial applicability

[0061] This invention can also be applied to blood purification devices with different appearances, additional functions, etc., as long as the blood purification device is equivalent to the spirit of this invention.

[0062] Explanation of reference numerals in the attached figures

[0063] 1. Dual pump (transfer unit)

[0064] 1a Inhalation section

[0065] 1b Emissions Department

[0066] 2 Ultrafiltration Pump

[0067] 3. Heat exchanger

[0068] 4 heating units

[0069] 5. Degasser

[0070] 6 throttling orifices

[0071] 7. Degassing pump

[0072] 8a, 8b infusion pumps

[0073] 9a, 9b mixing chambers

[0074] 10, 11 Capture Department

[0075] 10a, 11a bubble filters

[0076] 10b, 11b First Area

[0077] 10c, 11c Second Region

[0078] 12 Degassing Chamber

[0079] 13 Control Unit

[0080] L1 Dialysis fluid inlet line

[0081] L2 drain line

[0082] L3-L5 bypass pipeline

[0083] L6 Detour Pipeline

[0084] L6a connecting pipeline

[0085] L7 A Pharmaceutical Solution Inlet Line

[0086] L8 B Drug Solution Inlet Line

[0087] L9 circulation pipeline

[0088] N1 and N2 degassing pipelines

[0089] C. Dialyzer (blood purification device)

[0090] C1 Blood Inlet

[0091] C2 Blood Outlet

[0092] C3 dialysate inlet

[0093] C4 Dialysis fluid outlet

[0094] K Blood Circuit

[0095] K1 Arterial Blood Circuit

[0096] K2 venous blood circuit

[0097] T1 A Pharmaceutical Solution Storage Tank

[0098] T2 B Pharmaceutical Solution Storage Tank

[0099] T temperature sensor

[0100] S1, S2 hydraulic detectors

[0101] P. Pressure pump.

Claims

1. A blood purification device configured to purify a patient's blood by circulating blood extracorporeally through a blood purifier and a blood circuit, the blood purification device comprising: The pipeline section includes: a dialysate inlet pipeline that introduces dialysate into the blood purifier; and a drain pipeline that drains drain fluid from the blood purifier. A conveying unit configured to convey fluid in the pipeline section; and The control unit controls the delivery unit to execute blood purification treatment and degreasing / cleaning procedures. When performing blood purification treatment, in which dialysate is delivered to the blood purifier, this blood purification treatment procedure is executed. This involves preparing dialysate by mixing and diluting solutions A and B introduced into the tubing to a predetermined concentration. When performing degreasing / cleaning, in which bicarbonate solution is passed through the tubing to remove grease, this degreasing / cleaning procedure is executed. This involves obtaining the bicarbonate solution by heating the solution B introduced into the tubing. The control unit releases carbon dioxide to the outside of the pipeline during the degreasing and cleaning process. This carbon dioxide is generated when the bicarbonate solution is circulated. The dialysate inlet line is equipped with a capture section for capturing air bubbles in the dialysate during the blood purification treatment process, while allowing the dialysate to flow through the capture section. The capture section includes: a bubble filter that captures air bubbles contained in the dialysate; a first region, an upstream portion of the bubble filter, configured to store the air bubbles captured by the bubble filter; and a second region, a downstream portion of the bubble filter, configured to allow dialysate that has passed through the bubble filter to flow through the second region. In this process, when the bicarbonate solution is circulated during the degreasing and cleaning step, the bubble filter of the capturing section captures carbon dioxide.

2. The blood purification device according to claim 1, further comprising: A hydraulic detector, configured to detect hydraulic pressure, is positioned on the downstream or upstream side of the dialysate inlet line relative to the capture section. If a predetermined change in hydraulic pressure is detected by the hydraulic detector during the degreasing and cleaning process, the control unit causes the carbon dioxide captured by the capture unit to be discharged to the outside of the pipeline section.

3. The blood purification device according to claim 2, in, The pipeline section includes: a bypass pipeline connecting and communicating the first area with the drainage pipeline; and a switching valve configured to open and close the flow path by opening and closing the bypass pipeline. In the degreasing and cleaning process, if the hydraulic detector detects a predetermined change in hydraulic pressure, the control unit opens the switch valve, thereby allowing the carbon dioxide in the first area to be discharged to the outside of the pipeline section through the bypass pipeline and the drain pipeline.

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