Blood purification device

Abstract

A blood purification apparatus is provided which is configured to use a B medicament solution used in a blood purification treatment process also as an alkaline medicament in a de-greasing process, thereby achieving reliable and smooth performance of the de-greasing process. The blood purification apparatus includes a line section, a double pump (1), and a control unit (13). The line section includes a dialysate introduction line (L1) and a drain discharge line (L2). The control unit (13) is configured to execute a blood purification treatment process and a de-greasing process. The blood purification treatment process is executed when a blood purification treatment in which dialysate is delivered to a dialyzer (C) is executed. The dialysate is prepared by diluting an A medicament solution and a B medicament solution to predetermined concentrations. The de-greasing process is executed when a de-greasing in which grease in the line section is removed by causing a sodium carbonate solution obtained from the B medicament solution introduced to the line section to flow through the line section is executed. The control unit (13) uses a heating unit (4) and a de-aerator (5) when a bicarbonate solution generation process in which a predetermined amount of a bicarbonate solution is generated while discharging carbon dioxide is executed, and when the de-greasing process in which the sodium carbonate solution is used is executed after the bicarbonate solution generation process.

Description

Technical Field

[0001] This invention relates to a blood purification device that purifies a patient's blood by circulating blood outside the body through a blood purifier and a blood circuit. Background Technology

[0002] A typical dialysis device, intended for blood purification purposes such as dialysis treatment, includes a tubing section and a delivery unit. The tubing section includes a dialysate inlet line through which dialysate is introduced into the blood purifier; and a drain line through which drained fluid is discharged from the blood purifier. The delivery unit is configured to deliver dialysate and drained fluid within the tubing section. Additionally, a blood circuit for circulating the patient's blood outside the body is connected to the blood purifier. Dialysis treatment (blood purification therapy) is performed using the blood purifier while the patient's blood is circulated outside the body within the blood circuit.

[0003] Generally, such blood purification devices maintain cleanliness over a long period by periodically performing a degreasing cleaning process, in which grease is washed away, for example, by allowing an alkaline agent such as sodium carbonate or sodium hypochlorite to flow through a relevant flow path contained in the pipeline. In the known art, a solution of reagent B used to prepare the dialysate is heated to generate a sodium carbonate solution, which is then used as the alkaline agent flowing through the pipeline in the degreasing cleaning process (see, for example, Patent Document 1).

[0004] In this technology, if the sodium carbonate solution obtained by heating the B-type reagent solution used to prepare dialysate in dialysis treatment is also used as the alkaline reagent in the degreasing and cleaning process, then a portion of the B-type reagent solution remaining in dialysis treatment can be reused. Therefore, the cost of the reagents is reduced. Furthermore, reducing the number of different reagent types used in the degreasing and cleaning process reduces the labor required for management.

[0005] Existing technical documents

[0006] Patent documents

[0007] Patent Document 1: Japanese Patent Application Publication No. 2018-118033 Summary of the Invention

[0008] The technical problem to be solved by the present invention

[0009] In the aforementioned known blood purification apparatus, although the B-type reagent solution used in dialysis treatment (blood purification treatment process) can be reused as an alkaline reagent (sodium carbonate solution) in the degreasing and cleaning process, the carbon dioxide (CO2) generated by heating the B-type reagent solution may accumulate in the pipeline and hinder the good performance of the degreasing and cleaning process. In the technique of heating the B-type reagent solution to generate sodium carbonate solution for use as an alkaline reagent in the degreasing and cleaning process, the amount of sodium carbonate solution may be insufficient, leading to unavoidable interruptions in the degreasing and cleaning process.

[0010] The present invention was made in view of the above circumstances, and its object is to provide a blood purification device configured to use the B agent solution used in the blood purification treatment process as an alkaline agent in the degreasing and cleaning process, thereby ensuring stable performance of the degreasing and cleaning process.

[0011] Solution to the problem

[0012] A blood purification apparatus according to an embodiment of the present invention is configured to purify a patient's blood by circulating blood extracorporeally through a blood purifier and a blood circuit. The apparatus includes: a pipeline section comprising a dialysate inlet pipeline for introducing dialysate into the blood purifier and a drain pipeline for draining wastewater from the blood purifier; a delivery unit configured to deliver dialysate and wastewater in the pipeline section; a control unit configured to perform a blood purification treatment step and a degreasing cleaning step, wherein the blood purification treatment step is performed when dialysate is delivered to the blood purifier. The dialysate is prepared by mixing and diluting a drug solution A and a drug solution B introduced into the pipeline section to a predetermined concentration; the degreasing cleaning step is performed when a degreasing cleaning step is performed to remove grease from the pipeline section by flowing a bicarbonate solution through the pipeline section; a heating unit configured to heat the drug solution B introduced into the pipeline section; and a degasser configured to discharge carbon dioxide to the outside of the pipeline section, the carbon dioxide being generated by the drug solution B heated by the heating unit. When performing the bicarbonate solution generation process, in which a predetermined amount of bicarbonate solution is generated and carbon dioxide is discharged, and when performing the degreasing and cleaning process using the bicarbonate solution after the bicarbonate solution generation process, the control unit uses a heating unit and a degassing device.

[0013] Invention Effects

[0014] According to the present invention, when performing a bicarbonate solution generating step in which a predetermined amount of bicarbonate solution is generated and carbon dioxide is discharged, and when performing a degreasing and cleaning step in which a bicarbonate solution is used after the bicarbonate solution generating step, a heating unit and a degasser are used. Therefore, by using the B-type reagent solution used in the blood purification treatment process as an alkaline agent in the degreasing and cleaning step, reliable and stable performance of the degreasing and cleaning step can be achieved. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of a blood purification device according to an embodiment of the present invention.

[0016] Figure 2 This is a schematic diagram illustrating the blood purification treatment process performed by a blood purification device.

[0017] Figure 3 This is a schematic diagram illustrating the bicarbonate solution generation process performed by a blood purification device.

[0018] Figure 4 This is a schematic diagram illustrating the degreasing and cleaning process performed by a blood purification device.

[0019] Figure 5 This is a flowchart representing the control sequence executed by the control unit included in the blood purification device.

[0020] Figure 6 This is a schematic diagram of a part of a blood purification device according to another embodiment of the present invention, which serves as a heating unit and a degasser. Detailed Implementation

[0021] Embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0022] The blood purification device in this embodiment is configured to purify the patient's blood by circulating blood outside the body through a blood purifier and a blood circuit. For example... Figure 1 As shown, the blood purification device includes: a blood circuit K, which includes an arterial blood circuit K1 and a venous blood circuit K2; a dialyzer C, which serves as a blood purifier; a pipeline section, which includes a dialysate inlet pipeline L1 and a dialysate outlet pipeline L2; a dual pump 1, which serves as a delivery unit; and a control unit 13.

[0023] Arterial blood circuit K1 has a connector at its distal end. An arterial puncture needle can be connected to arterial blood circuit K1 via the connector. Arterial blood circuit K1 also has a peristaltic pump and an arterial air trap chamber located midway through its path. Venous blood circuit K2 has a connector at its distal end. A venous puncture needle can be connected to venous blood circuit K2 via the connector. Venous blood circuit K2 also has a venous air trap chamber located midway through its path.

[0024] The dialyzer C (blood purifier) ​​has a blood inlet C1, a blood outlet C2, a dialysate inlet C3 (the inlet of the dialysate flow path, or dialysate inlet), and a dialysate outlet C4 (the outlet of the dialysate flow path, or dialysate delivery outlet) within its housing. An arterial blood circuit K1 is connected to the blood inlet C1. A venous blood circuit K2 is connected to the blood outlet C2. The dialysate inlet C3 and the dialysate outlet C4 are connected to the dialysate inlet line L1 and the dialysate outlet line L2, respectively.

[0025] Dialyzer C houses multiple hollow fiber membranes (not shown) formed of hollow fibers, serving as blood purification membranes for purifying the blood. The blood purification membranes in dialyzer C define blood flow paths (each extending between a blood inlet C1 and a blood outlet C2) and dialysate flow paths (each extending between a dialysate inlet C3 and a dialysate outlet C4). The hollow fiber membranes constituting the blood purification membranes have multiple tiny pores (micropores) extending from the outer peripheral surface to the inner peripheral surface. Impurities in the blood permeate through the membrane into the dialysate.

[0026] When an arterial puncture needle connected to the distal end of the arterial blood circuit K1 and a venous puncture needle connected to the distal end of the venous blood circuit K2 are used to puncture the patient, the blood pump is activated. The patient's blood flows through the arterial blood circuit K1 and reaches the dialyzer C, where it is purified. The purified blood then flows through the venous blood circuit K2 and returns to the patient. Thus, the patient's blood is purified by the dialyzer C while simultaneously circulating extracorporeally within the blood circuit K.

[0027] The main body of the device includes a pipeline section and a dual pump 1 (delivery unit). The pipeline section includes: a dialysate inlet line L1 through which dialysate is introduced into the dialyzer C; and a drain line L2 through which drain fluid is discharged from the dialyzer C. The dual pump 1 is configured to deliver dialysate and drain fluid within this pipeline section. The dual pump 1 includes: an intake section 1a connected to the dialysate inlet line L1, and a discharge section 1b connected to the drain line L2. That is, the dual pump 1 is positioned between the dialysate inlet line L1 and the drain line L2. When the dual pump 1 is activated, dialysate is introduced into the dialyzer C through the dialysate inlet line L1, and then discharged from the dialyzer C along with waste products and excess water from the blood through the drain line L2. The dual pump 1 can be replaced by any other device (e.g., a device including a so-called balance chamber).

[0028] like Figure 1As shown, the pipeline section includes a dialysate inlet line L1 and a drain line L2; it also includes bypass lines L3 to L5, which are respectively connected to the dialysate inlet line L1 and the drain line L2; a detour line L6, which is detoured to the discharge section 1b of the double pump 1 of the drain line L2; and A-reagent solution inlet line L7 and B-reagent solution inlet line L8, with the dialysate inlet line L1 connected to the A-reagent solution storage tank T1 and the B-reagent solution storage tank T2 respectively through the A-reagent solution inlet line L7 and the B-reagent solution inlet line L8.

[0029] Bypass lines L3 to L5 are equipped with solenoid valves V5 to V7, respectively. Solenoid valves V8 and V9 are installed on the A-solution inlet line L7 and the B-solution inlet line L8, respectively. Infusion pumps 8a and 8b are also installed on the A-solution inlet line L7 and the B-solution inlet line L8, respectively. When infusion pump 8a is started with solenoid valve V8 open, the A-solution inlet in tank T1 is introduced into the dialysate inlet line L1 through the A-solution inlet line L7. When infusion pump 8b is started with solenoid valve V9 open, the B-solution inlet in tank T2 is introduced into the dialysate inlet line L1 through the B-solution inlet line L8.

[0030] The dialysate inlet line L1 is equipped with solenoid valves V1 and V3, a heat exchanger 3, a heating unit 4, a degassing pump 7, a degasser 5, stirring chambers 9a and 9b, and capture units 10 and 11. The heat exchanger 3 includes a flow path for supplying purified water (RO water) to the dialysate inlet line L1 and a flow path for drained liquid flowing in the drain line L2. Heat exchange occurs between the two flow paths in the heat exchanger 3, with the heat from the drained liquid being transferred to the purified water.

[0031] Heating unit 4 is a heater installed on the dialysate inlet line L1, capable of heating the purified water supplied to the dialysate inlet line L1. Downstream of heating unit 4 ( Figure 1 A temperature sensor t is installed on the right side of the heating unit 4, which is configured to detect the temperature (water temperature) of the purified water heated by the heating unit 4. A throttling orifice 6 is provided downstream of the temperature sensor t. When the deaeration pump 7 is started, the purified water flowing through the throttling orifice 6 is introduced into the deaerator 5.

[0032] The degasser 5 is a chamber connected to the dialysate inlet line L1, and a circulation line L9 (circulation flow path) is provided at its bottom. The circulation line L9 is part of the pipeline section and is connected to a predetermined position upstream of the dialysate inlet line L1 of the degasser 5 (the position between the heat exchanger 3 and the heating unit 4), so that the purified water supplied to the dialysate inlet line L1 can circulate therein. The degasser 5 is also provided with a degassing line N1 at its top. The degassing line N1 extends to the drain line L2, so that the air bubbles collected by the degasser 5 can be discharged to the outside of the pipeline section through the degassing line N1.

[0033] Solution A and Solution B have different compositions for generating dialysate. Specifically, Solution A (Solution A) is a mixed aqueous solution containing sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium acetate, etc. Solution B (Solution B) is an aqueous solution of sodium bicarbonate (NaHCO3). Solution A and Solution B are stored in predetermined amounts in storage tanks T1 and T2, respectively. When infusion pumps 8a and 8b are started, Solution A and Solution B are introduced into dialysate inlet line L1.

[0034] The A and B reagent solutions, introduced into the dialysate inlet line L1 via A reagent solution inlet line L7 and B reagent solution inlet line L8, are mixed and diluted with purified water in stirring chambers 9a and 9b, thereby preparing dialysate of a predetermined concentration. Specifically, while the purified water supplied to the dialysate inlet line L1 circulates in the circulation line L9, the purified water is heated by the heating unit 4 and degassed (air bubbles are removed) by the deaerator 5. The heated and degassed purified water is then mixed with the A and B reagent solutions to obtain dialysate of a predetermined concentration.

[0035] Capture units 10 and 11 are configured to capture air bubbles in the dialysate during a blood purification treatment process, while allowing the dialysate to flow through them. Capture units 10 and 11 include: respective bubble filters 10a and 11a; respective first regions 10b and 11b, located upstream of each bubble filter 10 and 11a and storing the captured air bubbles therein; and respective second regions 10c and 11c, located downstream of each bubble filter 10a and 11a and allowing the received dialysate to flow through them. The first region 10b of capture unit 10 is connected to the drain line L2 via a bypass line L4. The first region 11b of capture unit 11 is connected to the drain line L2 via a bypass line L5.

[0036] The dialysate inlet line L1 is also equipped with hydraulic detectors S1 and S2. Hydraulic detectors S1 and S2 are located downstream (or upstream) of each bubble filter 10a and 11a, and each detector is a sensor capable of detecting hydraulic pressure. During the blood purification treatment process, if either hydraulic detector S1 or S2 detects a predetermined change in hydraulic pressure, the corresponding solenoid valves V6 and V7 (switching valves) are opened, thereby allowing air bubbles in the first regions 10b and 11b to be discharged to the outside of the pipeline section through bypass lines L4 and L5 and the drain line L2.

[0037] Solenoid valves V2 and V4, a pressurizing pump P, and a degassing chamber 12 are installed on the drainage line L2. An ultrafiltration pump 2 is installed on the detour line L6 of the drainage section 1b of the detour double pump 1. The ultrafiltration pump 2 is used to remove water (excess water) from the patient's blood flowing through the dialyzer C. Specifically, when the ultrafiltration pump 2 is activated, the amount of drainage L2 discharged through the drainage line becomes greater than the amount of dialysate introduced through the dialysate inlet line L1. Therefore, the amount of water corresponding to this difference is removed from the blood.

[0038] The degassing chamber 12 is a cavity connected to the drain line L2, and its bottom is connected to a predetermined position on the bypass line L6 via a connecting line L6a. The degassing chamber 12 is also connected to the degassing line N2 at its top. The degassing line N2 extends downstream of the drain line L2, allowing air bubbles collected by the degassing chamber 12 to be discharged to the outside of the line section through the degassing line N2. The degassing line N2 is equipped with a solenoid valve V10, allowing it to be opened and closed at any time.

[0039] The control unit 13 is a microcomputer installed in the main body of the device. During blood purification treatment, the control unit 13 is configured to execute the blood purification treatment process, in which dialysate is delivered to the dialyzer C. The dialysate is prepared by mixing drug solution A and drug solution B in the inlet tubing and diluting drug solutions A and B to a predetermined concentration. Specifically, in the blood purification treatment process, such as... Figure 2 As shown, open solenoid valves V8 and V9, start infusion pumps 8a and 8b, and start the dual pump 1 and ultrafiltration pump 2. This introduces the A and B reagent solutions from the dialysate inlet line L1, which are then mixed with purified water to form a dialysate of the predetermined concentration. The resulting dialysate is then delivered to dialyzer C for dialysis treatment to purify and ultrafilter the patient's blood.

[0040] In addition to the blood purification treatment process, the control unit 13 of this embodiment can also use the heating unit 4 and the degasser 5 to perform the following processes: a bicarbonate solution generation process, wherein a predetermined amount of bicarbonate solution is generated while carbon dioxide is discharged; and a degreasing cleaning process, which performs degreasing cleaning, wherein grease in the pipeline section is removed by allowing the bicarbonate solution to flow through the pipeline section. The bicarbonate solution is obtained by heating the B agent solution introduced into the pipeline section. The bicarbonate solution generation process is a process of generating an alkaline agent (sodium carbonate solution) from the B agent solution used in the blood purification treatment process. The alkaline agent is used in the degreasing cleaning process, wherein degreasing cleaning is performed by allowing the alkaline agent generated in the bicarbonate solution generation process to flow through the pipeline section.

[0041] More specifically, the bicarbonate solution preparation process is carried out as follows. For example... Figure 3 As shown, the distal end of the dialysate inlet line L1 and the distal end of the drain line L2 are connected to each other via coupler D to establish a short circuit. Furthermore, solenoid valves V4, V5, and V9 are opened, while the other solenoid valves are closed. Additionally, the degassing pump 7 and the infusion pump 8b are started. During this process, the dual pump 1, the ultrafiltration pump 2, and other devices are stopped. Thus, the B reagent solution in the B reagent solution storage tank T2 is introduced into the dialysate inlet line L1, heated by the heating unit 4, and circulated in the circulation line L9.

[0042] When the B reagent solution (sodium bicarbonate (NaHCO3)) circulates through the circulation line L9, the B reagent solution is diluted and heated by the heating unit 4 (to approximately 65°C or higher), thereby decomposing into sodium carbonate (Na2CO3), water (H2O), and carbon dioxide (CO2). Therefore, a sodium carbonate solution (bicarbonate solution) is obtained from the B reagent solution as an alkaline reagent used in the degreasing and cleaning process. The carbon dioxide generated by the heating of the B reagent solution by the heating unit 4 is collected by the degasser 5 and discharged to the outside of the pipeline section through the degassing line N1 and the drain line L2.

[0043] In the bicarbonate solution generation process, heating unit 4 heats the B reagent solution introduced into the pipeline, and degasser 5 discharges the carbon dioxide generated by the B reagent solution heated by heating unit 4 to the outside of the pipeline. That is, in the process of circulating the B reagent solution in the circulation pipeline L9, while the B reagent solution heated by heating unit 4 generates sodium carbonate solution (bicarbonate solution), carbon dioxide is discharged by degasser 5.

[0044] In summary, the heating unit 4 and the degasser 5 are used to perform the following steps. In the blood purification treatment step, the purified water circulating in the circulation line L9, used to prepare a dialysate of a predetermined concentration by mixing drug solution A and drug solution B, is heated and degassed. Furthermore, in the bicarbonate solution generation step, carbon dioxide is discharged while generating a sodium carbonate solution by heating drug solution B. After performing the bicarbonate solution generation step using the heating unit 4 and the degasser 5 to generate a predetermined amount of sodium carbonate solution while discharging carbon dioxide, the sodium carbonate solution is used in the degreasing and cleaning step.

[0045] This embodiment also employs a storage unit configured to store a predetermined amount of sodium carbonate solution generated by heating the B reagent solution. The storage unit is a flow path within a predetermined section of the pipeline. In this embodiment, the storage unit includes a flow path of the heat exchanger 3 (heat exchanger flow path). The heat exchanger flow path is the section in the dialysate inlet pipeline L1 that exchanges heat with the drain pipeline L2. Specifically, the storage unit is located upstream of the connection between the dialysate inlet pipeline L1 and the B reagent solution inlet pipeline L8. Figure 3 The flow path (on the left side of the structure) includes a circulation line L9, a heat exchanger flow path for heat exchanger 3, and a bypass line L3. The storage unit can store the sodium carbonate solution generated during the bicarbonate solution generation process.

[0046] In the degreasing and cleaning process, such as Figure 4 As shown, the distal end of the dialysate inlet line L1 and the distal end of the drain line L2 are coupled together via coupler D. Furthermore, solenoid valves V1, V2, V5, and V10 are open, while the other solenoid valves are closed. Additionally, the degassing pump 7, the dual pump 1, the ultrafiltration pump 2, and the booster pump P are started. During this process, infusion pumps 8a and 8b are stopped. Furthermore, solenoid valves V5 to V7 are open at any time during the degreasing cleaning of bypass lines L3 to L5. This causes the sodium carbonate solution stored in the storage section to flow and circulate within the pipeline section, thereby achieving degreasing cleaning.

[0047] Now, refer to Figure 5 The flowchart shown illustrates the control sequence executed by the control unit 13 according to this embodiment.

[0048] First, a preparatory cleaning operation (S1) is performed. Specifically, the distal end of the dialysate inlet line L1 is short-circuited with the distal end of the drain line L2 via a coupler D, and purified water is supplied into the dialysate inlet line L1 and flows through the relevant flow paths included in the line section. As a result, the dialysate in the line section is washed away.

[0049] Next, as Figure 3As shown, the B reagent solution in the storage tank T2 is introduced into the dialysate inlet line L1 (S2) to perform the bicarbonate solution generation process. In this process, the B reagent solution is circulated in the circulation line L9 and heated by the heating unit 4. Therefore, a sodium carbonate (Na2CO3) solution of a predetermined concentration is generated, while carbon dioxide (CO2) is discharged through the degassing line N1 (S3).

[0050] The resulting sodium carbonate solution is stored in a storage compartment located upstream of the connection between dialysate inlet line L1 and reagent B inlet line L8. Figure 3 The flow path (on the left side of the flow path) includes the circulation line L9, the heat exchanger flow path of the heat exchanger 3, and the bypass line L3. Then, in S4, it is checked whether the injection volume of the B reagent solution has reached the specified value or greater. If it is determined that the injection volume has reached the specified value or greater, the process proceeds to S5, where a degreasing and cleaning process is performed.

[0051] In the degreasing and cleaning process, such as Figure 4 As shown, the dual pump 1 and other related devices are started, thereby circulating the sodium carbonate solution stored in the storage section in the relevant flow path of the pipeline section (S5). In the degreasing cleaning process, the A-solution storage tank T1 and the B-solution storage tank T2 can be separated from the A-solution inlet line L7 and the B-solution inlet line L8. Therefore, the sodium carbonate solution can also flow through the A-solution inlet line L7 and the B-solution inlet line L8 for degreasing cleaning. Regardless of the method, patient-derived proteins can be removed by the cleaning action of the sodium carbonate solution. Therefore, degreasing cleaning of the pipeline section is achieved.

[0052] When the degreasing and cleaning process is completed, a final cleaning operation (S6) is performed. Specifically, purified water is supplied to the dialysate inlet line L1 and flows through the relevant flow paths included in the line section. As a result, the sodium carbonate solution in the line section is washed away. Through the above operations, the bicarbonate solution generation process and the degreasing and cleaning process are completed. Since the line section has been cleaned and disinfected, another round of blood purification treatment is ready to be performed.

[0053] According to this embodiment, when performing a bicarbonate solution generation step in which a predetermined amount of bicarbonate solution is generated and carbon dioxide is discharged, and when performing a degreasing and cleaning step in which a sodium carbonate solution is used after the bicarbonate solution generation step, a heating unit 4 and a degasser 5 are used. Therefore, by using the B-type drug solution used in the blood purification treatment process as an alkaline agent in the degreasing and cleaning step, reliable and stable performance of the degreasing and cleaning step can be achieved.

[0054] Additionally, the blood purification device of this embodiment includes a B-drug solution inlet line L8, through which the B-drug solution is introduced into the pipeline section. The heating unit 4 and the degassing device 5 are aligned with the conveying direction of the sodium carbonate solution in the degreasing and cleaning process. Figure 3 The storage unit (located upstream of the connection between the dialysate inlet line L1 and the B reagent solution inlet line L8, and including the flow path of the circulation line L9, the heat exchanger flow path of the heat exchanger, and the bypass line L3) is located upstream of the heating unit 4 and the degasser 5 along the conveying direction. The control unit 13 performs the bicarbonate solution generation process, thereby controlling the flow path of the bicarbonate solution in the opposite direction to the conveying direction via the heating unit 4 and the degasser 5. Figure 3 The B-reagent solution introduced from the B-reagent solution introduction line L8 (in the left direction) is heated and degassed to generate a bicarbonate solution, which is then further conveyed in the opposite direction to the conveying direction and stored in the storage unit. Therefore, the B-reagent solution is heated and degassed immediately after introduction. Furthermore, a predetermined amount of B-reagent solution is continuously introduced from the heating unit 4 and the degassed section 5 into the storage unit by flowing it in the opposite direction to the conveying direction.

[0055] Additionally, the pipeline section includes a circulation pipeline L9 (circulation flow path) through which the B reagent solution introduced into the pipeline section is circulated. During the process of circulating the B reagent solution in the circulation pipeline L9, while the B reagent solution heated by the heating unit 4 generates a sodium carbonate solution, carbon dioxide is discharged through the degasser 5. The carbon dioxide generated along with the sodium carbonate is reliably and efficiently discharged to the outside of the pipeline section.

[0056] Furthermore, in the blood purification treatment process, the purified water used to prepare a dialysate of a predetermined concentration by mixing drug solution A and drug solution B circulating in circulation line L9 is heated and degassed by heating unit 4 and degasser 5. That is, the heating unit 4, degasser 5, and circulation line L9 used in the blood purification treatment process can also be used in the bicarbonate solution generation process in which drug solution B is heated, degassed, and circulated.

[0057] Furthermore, the blood purification device includes a storage section configured to store a predetermined amount of bicarbonate solution generated by heating the B reagent solution. Therefore, the amount of sodium carbonate solution required for the degreasing and cleaning process is obtained during the bicarbonate solution generation step. Specifically, the storage section is a flow path within a predetermined portion of the pipeline section. Therefore, no additional components are required to obtain the storage section. Additionally, the storage section includes a heat exchanger flow path for a heat exchanger 3, which is part of the dialysate inlet pipeline L1 and exchanges heat with the drain pipeline L2. Therefore, a relatively large amount of sodium carbonate solution can be stored.

[0058] In another implementation, such as Figure 6 As shown, the storage unit can be a container 15. The container 15 is equipped with a heating unit 14 and a degassing line N3, which serves as a degasser. The container 15 is capable of storing a predetermined amount of sodium carbonate solution generated by heating the B reagent solution by the heating unit 14. The container 15, as the storage unit, is connected to the dialysate inlet line L1 and also to the B reagent solution storage tank T2 via the B reagent solution inlet line L8.

[0059] Heating unit 14 is disposed inside container 15. Degassing line N3 extends from the top of container 15, allowing any gas (carbon dioxide) in container 15 to be released to the outside. Container 15 stores purified water supplied to dialysate inlet line L1. When performing the bicarbonate solution generation process, infusion pump 8b is activated with solenoid valve V9 open, thereby introducing reagent B solution from reagent B storage tank T2 into container 15.

[0060] Thus, the B agent solution is diluted with purified water in container 15 and heated by heating unit 14, thereby generating a sodium carbonate (Na2CO3) solution of a predetermined concentration, while carbon dioxide (CO2) is discharged through degassing line N3. In such an embodiment, if the storage unit is a container equipped with heating unit 14 and degassing line N3 serving as a degasser, and configured to store the sodium carbonate solution generated by heating the B agent solution by heating unit 14, then the reliable generation of sodium carbonate solution required in the degreasing and cleaning process and the reliable emission of carbon dioxide are achieved.

[0061] Additionally, container 15 is connected to dialysate inlet line L1, and heating unit 14 and degassing line N3 (which acts as a degasser) are used in the blood purification treatment process to mix purified water, drug solution A, and drug solution B to prepare dialysate of a predetermined concentration. That is, container 15 is used in both the blood purification treatment process and the bicarbonate solution generation process. Container 15 does not necessarily need to be connected to dialysate inlet line L1; for example, it can be connected to drug solution B inlet line. In this case, container 15 can be used without changing the components connected to dialysate inlet line L1 and their arrangement.

[0062] Although some embodiments have been described above, the present invention is not limited thereto. For example, the degassing line N3, which discharges carbon dioxide generated in the bicarbonate solution generation process, can be replaced with a line that is open to the atmosphere and releases carbon dioxide to the outside air. In addition, the heating unit 4 and the degasser 5 can be any device used in the blood purification treatment process as described in the above embodiments, or they can be dedicated devices not used in the blood purification treatment process.

[0063] The above embodiments relate to a case where a sodium carbonate solution, obtained by heating a solution of drug B introduced into the pipeline, is used to degrease and clean the pipeline section. Alternatively, a bicarbonate solution different from the sodium carbonate solution can be used. Furthermore, although the above embodiments relate to single-patient dialysis devices, the present invention is also applicable to other blood purification devices such as multi-patient dialysis devices.

[0064] Industrial applicability

[0065] This invention can also be applied to blood purification devices with different appearances, additional functions, etc., as long as the blood purification device is equivalent to the spirit of this invention.

[0066] Explanation of reference numerals in the attached figures

[0067] 1. Dual pump (transfer unit)

[0068] 1a Inhalation section

[0069] 1b Emissions Department

[0070] 2 Ultrafiltration Pump

[0071] 3. Heat exchanger

[0072] 4 heating units

[0073] 5. Degasser

[0074] 6 throttling orifices

[0075] 7. Degassing pump

[0076] 8a, 8b infusion pumps

[0077] 9a, 9b mixing chambers

[0078] 10, 11 Capture Department

[0079] 10a, 11a bubble filters

[0080] 10b, 11b First Area

[0081] 10c, 11c Second Region

[0082] 12 Degassing Chamber

[0083] 13 Control Unit

[0084] 14 Heating Units

[0085] 15 Containers

[0086] L1 Dialysis fluid inlet line

[0087] L2 drain line

[0088] L3~L5 bypass pipeline

[0089] L6 Detour Pipeline

[0090] L6a connecting pipeline

[0091] L7 A Pharmaceutical Solution Inlet Line

[0092] L8 B Drug Solution Inlet Line

[0093] L9 circulation pipeline

[0094] N1, N2, N3 degassing pipelines

[0095] C. Dialyzer (blood purification device)

[0096] C1 Blood Inlet

[0097] C2 Blood Outlet

[0098] C3 dialysate inlet

[0099] C4 Dialysis fluid outlet

[0100] K Blood Circuit

[0101] K1 Arterial Blood Circuit

[0102] K2 venous blood circuit

[0103] T1 A Pharmaceutical Solution Storage Tank

[0104] T2 B Pharmaceutical Solution Storage Tank

[0105] T temperature sensor

[0106] S1, S2 hydraulic detectors

[0107] P. Pressure pump.

Claims

1. A blood purification device configured to purify a patient's blood by circulating blood extracorporeally through a blood purifier and a blood circuit, the blood purification device comprising: The pipeline section includes: a dialysate inlet pipeline that introduces dialysate into the blood purifier; and a drain pipeline that drains drain fluid from the blood purifier. A delivery unit configured to deliver dialysate and drain fluid from the pipeline section; The control unit is configured to perform a blood purification treatment process and a degreasing cleaning process. When performing blood purification treatment in which dialysate is delivered to the blood purifier, the blood purification treatment process is performed. The dialysate is prepared by mixing drug solution A and drug solution B introduced into the pipeline and diluting drug solution A and drug solution B to a predetermined concentration. When performing degreasing cleaning in which bicarbonate solution is flowed through the pipeline to remove grease from the pipeline, the degreasing cleaning process is performed. A heating unit configured to heat the B reagent solution introduced into the pipeline section; and A degasser, configured to discharge carbon dioxide to the outside of the pipeline section, the carbon dioxide being generated by the B reagent solution heated by the heating unit. Specifically, when performing the bicarbonate solution generation step, in which a predetermined amount of bicarbonate solution is generated and carbon dioxide is simultaneously discharged, and when performing the degreasing and cleaning step using sodium carbonate solution after the bicarbonate solution generation step, the heating unit and the degasser are used. The blood purification device also includes: a B-drug solution inlet line, through which the B-drug solution is introduced into the line section. The heating unit and the degasser are located upstream of the B reagent solution inlet pipeline, along the conveying direction of the bicarbonate solution in the degreasing and cleaning process. The blood purification device further includes a storage section located upstream of the heating unit and the degasser along the transport direction. The control unit performs the bicarbonate solution generation process, thereby generating a bicarbonate solution by heating and degassing the B reagent solution introduced from the B reagent solution inlet pipeline in the opposite direction to the conveying direction using the heating unit and the degasser, and thereby further conveying the bicarbonate solution in the opposite direction to the conveying direction and storing it in the storage unit.

2. The blood purification device according to claim 1, wherein, It also includes a circulation path that circulates the B reagent solution introduced into the pipeline section. In the process of circulating the B reagent solution through the circulation path, carbon dioxide is discharged through the degasser while the bicarbonate solution is generated from the B reagent solution heated by the heating unit.

3. The blood purification device according to claim 2, wherein, In this blood purification treatment process, the purified water circulating in the circulation path, which is used to prepare a dialysate of a predetermined concentration by mixing drug solution A and drug solution B, is heated and degassed by the heating unit and the degasser.

4. The blood purification device according to any one of claims 1 to 3, wherein, The storage section is a flow path within a predetermined part of the pipeline section.

5. The blood purification device according to claim 4, wherein, The storage section includes a heat exchanger flow path, which is part of the dialysate inlet line and exchanges heat with the drain line in the heat exchanger flow path.

6. The blood purification device according to any one of claims 1 to 3, wherein, The storage section is a container integrated with the heating unit and the degasser, and is configured to store a predetermined amount of bicarbonate solution produced by using the heating unit and the degasser.

7. The blood purification device according to claim 6, in, The container is configured to connect to the dialysate inlet line, and In this blood purification treatment process, the purified water used to prepare a dialysate of a predetermined concentration by mixing drug solution A and drug solution B is heated and degassed by the heating unit and the degasser.

8. The blood purification device according to claim 6, wherein, Also includes: A drug solution inlet line, through which drug solution A is introduced into the dialysate inlet line; and The B-drug solution is introduced into the pipeline through which the B-drug solution is introduced. The container is connected to the inlet line for the B drug solution.

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