A pharmaceutical composition for treating a cow's fore-stomach relaxation, and a preparation method and formulation thereof

Abstract

The application provides a pharmaceutical composition for treating bovine foregut atonia, which comprises, in parts by weight, Yuanhu 15-30 parts, Ru Xiang 15-30 parts, Muyu 25-45 parts, Chenpi 30-60 parts, Shanzha 24-45 parts, Huanglian 15-30 parts, Shengjiang 15-60 parts, Baizhi 15-30 parts, Shanyao 30-90 parts, Renshen 15-30 parts, Cangzhu 15-60 parts, Zhike 30-60 parts, Shichangpu 20-45 parts, Fuling 20-60 parts, Huangqi 20-60 parts; a preparation method thereof comprises the following steps: after cleaning the raw materials, the raw materials are respectively crushed, sieved and uniformly mixed; ethanol is added into the mixture, and after standing and heating reflux extraction, the mixture is reduced pressure filtered; the filtrate is concentrated and dried to be prepared; the application further provides a preparation of the above-mentioned pharmaceutical composition, which comprises the above-mentioned pharmaceutical composition and pharmaceutically acceptable adjuvant; the preparation can maintain gastrointestinal health, improve appetite, promote digestion, reduce stomach distension, soothe stomach qi, resist inflammation, resist bacteria and the like; not only can the preparation help to relieve the discomfort caused by bovine foregut atonia, but also can help to maintain the overall gastrointestinal health and remove potential toxicity and insecurity.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a medicine composition for treating bovine foregut atonia and a preparation method and preparation thereof. BACKGROUND

[0002] Bovine foregut atonia is a disease caused by various reasons leading to decreased excitability and weakened contraction of the foregut, slow movement of rumen contents, production of toxic substances, and digestive disorders, loss of appetite and other phenomena.

[0003] The disease belongs to the scope of "spleen deficiency and slow grass" in traditional Chinese veterinary medicine, and is mainly caused by poor feeding and excessive labor, resulting in spleen deficiency and water and grass relaxation. It is one of the common diseases of dairy cows. The main symptoms are pale mouth, yellowish tongue fur, often grinding teeth, and feces with incomplete digestion of feed mixed with mucus, often covered with mucus, and with a strong odor. The appetite and rumination stop, and some show mild to severe symptoms, with a long course, eventually leading to emaciation, rough coat, sunken eyes, lying down, soft rumen and other symptoms, causing serious economic losses to the dairy industry.

[0004] Clinical treatment with western medicine is prone to drug resistance and drug residues, which is harmful to human health. Therefore, a new traditional Chinese medicine treatment method is used to address the problem of bovine foregut atonia. SUMMARY

[0005] The present application aims to provide a medicine composition for treating bovine foregut atonia and a preparation method and preparation thereof, which can maintain gastrointestinal health, improve appetite, promote digestion, reduce stomach distension, calm stomach qi, and have anti-inflammatory and antibacterial effects. It not only helps to relieve the discomfort caused by bovine foregut atonia, but also helps to maintain overall gastrointestinal health and remove potential toxicity and insecurity.

[0006] The embodiments of the present application are implemented by the following technical solutions:

[0007] A medicine composition for treating bovine foregut atonia, by weight, comprises: Rhizoma Corydalis 15-30 parts, Olibanum 15-30 parts, Myrrh 25-45 parts, Pericarpium Citri Reticulatae 30-60 parts, Fructus Crataegi 24-45 parts, Rhizoma Coptidis 15-30 parts, Zingiber officinale Roscoe 15-60 parts, Radix Angelicae Dahuricae 15-30 parts, Dioscorea Opposita Thunb 30-90 parts, Radix Ginseng 15-30 parts, Atractylodes 15-60 parts, Fructus Aurantii 30-60 parts, Rhizoma Acori Graminei 20-45 parts, Poria cocos 20-60 parts, Radix Astragali 20-60 parts.

[0008] The preparation method of the above-mentioned medicine composition comprises the following steps:

[0009] (1) After cleaning each raw material, it is crushed, sieved and mixed uniformly;

[0010] (2) the mixture obtained in step (1) is added with 2-4 times of ethanol solution by mass, and after standing for 1-3 hours, the extraction is carried out for multiple times under heating and reflux, the extraction liquid is combined, and then is filtered under reduced pressure, and the filtrate is dried by concentration to obtain a product.

[0011] The application further provides a preparation of the above-mentioned pharmaceutical composition, comprising the above-mentioned pharmaceutical composition and pharmaceutically acceptable adjuvants; and the preparation is in any one of the forms of decoction, powder, pill, tablet, mixture, capsule, granule.

[0012] The technical scheme of the embodiment of the application has at least the following advantages and beneficial effects:

[0013] The application is formulated according to the specific symptoms and needs of bovine gastroparesis, to meet the special needs of bovine gastroparesis, and the components cooperate with each other and have synergistic effects, to maintain gastrointestinal health, improve appetite, promote digestion, reduce stomach distension, calm the stomach, and have anti-inflammatory and antibacterial effects. The application not only helps to relieve the discomfort caused by bovine gastroparesis, but also helps to maintain the overall gastrointestinal health, remove potential toxicity and insecurity, reduce the risk during treatment, and ensure the safety of treatment. The pharmaceutical composition formula of the application reflects the comprehensive application principle of traditional Chinese medicine, and provides more comprehensive treatment effect for bovine gastroparesis through the relationship of monarch, minister, assistant and guide, and synergistic effect. DETAILED DESCRIPTION

[0014] In order to make the purpose, technical scheme and advantages of the embodiments of the application more clear, the technical scheme in the embodiments of the application will be clearly and completely described below. If the specific conditions are not specified in the embodiments, the conventional conditions or the conditions recommended by the manufacturer are used. If the reagents or instruments are not specified by the manufacturer, they are all conventional products that can be purchased in the market.

[0015] The pharmaceutical composition for treating bovine gastroparesis, the preparation method and the preparation provided by the embodiments of the application will be specifically described below.

[0016] A pharmaceutical composition for treating bovine gastroparesis, comprising, by weight fraction: Rhizoma Corydalis 15-30 parts, Olibanum 15-30 parts, Myrrh 25-45 parts, Pericarpium Citri Reticulatae 30-60 parts, Fructus Crataegi 24-45 parts, Rhizoma Coptidis 15-30 parts, Rhizoma Zingiberis 15-60 parts, Radix Angelicae Dahuricae 15-30 parts, Rhizoma Dioscoreae 30-90 parts, Radix Ginseng 15-30 parts, Radix Atractylodis 15-60 parts, Fructus Aurantii 30-60 parts, Rhizoma Acori Graminei 20-45 parts, Poria 20-60 parts, Radix Paeoniae Alba 20-60 parts.

[0017] Further, by weight parts, including: Yuanhu 20-30 parts, frankincense 20-25 parts, myrrh 30-40 parts, dried tangerine or orange peel 35-50 parts, hawthorn 25-35 parts, Coptis 20-25 parts, ginger 20-50 parts, Bai Zhi 20-25 parts, yam 40-80 parts, ginseng 15-25 parts, atractylodes 20-50 parts, bitter orange 35-50 parts, Acorus 25-30 parts, Fuling 30-50 parts, Huangqi 30-50 parts.

[0018] Further, by weight parts, including: Yuanhu 30 parts, frankincense 20 parts, myrrh 30 parts, dried tangerine or orange peel 40 parts, hawthorn 30 parts, Coptis 20 parts, ginger 30 parts, Bai Zhi 20 parts, yam 50 parts, ginseng 15 parts, atractylodes 30 parts, bitter orange 40 parts, Acorus 25 parts, Fuling 40 parts, Huangqi 30 parts.

[0019] Further, by weight parts, including: Yuanhu 20 parts, frankincense 25 parts, myrrh 35 parts, dried tangerine or orange peel 40 parts, hawthorn 35 parts, Coptis 25 parts, ginger 40 parts, Bai Zhi 25 parts, yam 60 parts, ginseng 20 parts, atractylodes 35 parts, bitter orange 40 parts, Acorus 30 parts, Fuling 35 parts, Huangqi 40 parts.

[0020] Yuanhu: slightly bitter, bitter, warm; liver, spleen; promoting blood circulation, qi and pain. The analgesic effect of this product is significant. The action site is wide, long-lasting and non-toxic, and is a good analgesic. It also has the effects of promoting blood circulation and qi, and is often used for various pains caused by qi stagnation and blood stasis.

[0021] Frankincense: bitter, warm. Promote blood circulation and relieve pain. Enter the heart, liver and spleen. Promote blood circulation and relieve pain. This product has the effects of promoting blood circulation, relieving pain and promoting qi, and is mainly used for abdominal pain caused by blood stasis and qi stagnation, as well as sprains and pain of carbuncle and sores. Combined with myrrh, it can enhance the effect of promoting blood circulation and relieving pain.

[0022] Myrrh: bitter, flat. Enter the liver. Promote blood circulation, remove blood stasis, relieve pain and promote muscle growth. The functions of promoting blood circulation, relieving pain and promoting muscle growth of this product are basically similar to frankincense, and the usage is the same, so it is combined with frankincense to enhance the therapeutic effect.

[0023] Dried tangerine or orange peel: bitter, pungent, warm. Lungs, spleen. Regulating qi and invigorating spleen, drying dampness and reducing phlegm. The pungent can regulate the qi of the middle jiao and the spleen and stomach, so it can regulate the qi of the middle jiao and the spleen and stomach. When the qi is flowing, the pain will stop. Used for abdominal distension, loss of appetite, vomiting, diarrhea, etc. caused by disharmony of middle qi. Used for phlegm and dampness, reverse cough and asthma; used for abdominal distension and indigestion.

[0024] Hawthorn: sour, sweet, slightly warm. Enter the spleen, stomach and liver. Digestive and invigorating stomach, promoting blood circulation and removing blood stasis. This product can digest food and invigorate the stomach, especially for meat digestion and accumulation. Used for food accumulation, abdominal distension, etc. Treat food accumulation and stagnation; promote blood circulation and remove blood stasis, treat blood stasis and swelling pain, diarrhea and blood, etc.

[0025] Coptis chinensis: Bitter, cold. It enters the heart, liver, stomach, and large intestine meridians. It clears heat and dries dampness, drains fire and detoxifies. This herb is an essential medicine for clearing heat and drying dampness. It can be used for all damp-heat syndromes, especially those with damp-heat stagnation in the stomach and intestines; it has a strong effect in clearing heat and draining fire, and is used to treat excessive heart fire, mouth and tongue sores, heat accumulation in the triple burner, and nosebleeds; it is also good at clearing heat and detoxifying, and is used to treat intense heat, sores, and swelling.

[0026] Ginger: Pungent, slightly warm. It enters the spleen, lung, and stomach meridians. It releases exterior cold, warms the middle jiao to stop vomiting, and detoxifies. This herb can disperse exterior cold; warm the stomach and harmonize the middle jiao, suppress nausea and vomiting, making it an essential medicine for stopping vomiting and suitable for various vomiting symptoms; it can also detoxify the toxicity of Pinellia ternata and Arisaema heterophyllum.

[0027] Angelica dahurica: pungent, warm. Enters the lung and stomach meridians. Dispels wind and relieves pain, reduces swelling and drains pus, clears nasal passages. This herb can disperse wind-cold, dispel wind and relieve pain; disperse nodules and reduce swelling, drain pus and relieve pain; its nature is ascending, effectively clearing nasal passages.

[0028] Yam: Sweet, neutral. Enters the spleen, lung, and kidney meridians. It tonifies the spleen and stomach, generates fluids and benefits the lungs, and tonifies the kidneys and astringes essence. This herb is neutral in nature and not drying, with a mild effect. It is a mild tonic for the spleen and stomach, suitable for both spleen yang deficiency and stomach yin deficiency. It benefits lung qi and nourishes lung yin; it tonifies kidney qi and is used to treat kidney deficiency, spermatorrhea, and frequent urination.

[0029] Ginseng: Sweet, slightly bitter, neutral in nature. It enters the spleen, lung, and heart meridians. It greatly replenishes vital energy, restores the pulse and consolidates the body's defenses, tonifies the spleen and lungs, generates fluids, and calms the mind. It is used to treat various types of collapse syndromes; it is particularly effective when used alone.

[0030] Atractylodes lancea: pungent, bitter, and warm. It enters the spleen and stomach meridians. It dries dampness, strengthens the spleen, induces sweating to relieve exterior syndromes, and dispels wind-dampness. This herb has a fragrant, pungent aroma and is warm and drying in nature. It is used to treat dampness affecting the spleen and stomach, impaired digestion, loss of appetite, indigestion, and coldness in the stomach; its pungent and warm properties disperse and relieve exterior syndromes, and also dispel wind-dampness.

[0031] Fructus Aurantii Immaturus: Bitter, pungent, sour, and warm. It enters the spleen and stomach meridians. It regulates qi, relieves abdominal distension, and promotes digestion. It is used for abdominal distension caused by qi stagnation in the spleen and stomach, and phlegm-dampness; it is also used to treat constipation due to heat accumulation, and abdominal distension and pain.

[0032] Acorus tatarinowii: pungent, warm. Enters the heart, liver, and stomach meridians. It resolves dampness, stimulates appetite, clears the orifices, and resolves phlegm. It has aromatic effects in opening the orifices, and its aromatic properties also help to resolve dampness and strengthen the stomach. It is often used for dampness affecting the spleen and stomach, loss of appetite, and abdominal distension.

[0033] Poria cocos: Sweet, bland, and neutral. It enters the spleen, stomach, heart, lung, and kidney meridians. It promotes diuresis and eliminates dampness, strengthens the spleen and replenishes the middle jiao, and calms the mind and spirit. Its taste is sweet and bland; sweetness harmonizes the middle jiao, and blandness promotes diuresis. For those with water retention or a cold constitution, white Poria cocos is often used; for those with damp-heat, red Poria cocos is often used; if water retention manifests as edema or difficulty urinating, Poria cocos peel is often used. For spleen deficiency with dampness, slow digestion of water, loss of appetite, or water retention, Poria cocos has a dual effect of addressing both the root cause and the symptoms, as it can both strengthen the spleen and eliminate dampness, and can both tonify and purge. It can treat diarrhea; for those with spleen deficiency with dampness and impaired digestion, it has the effect of strengthening the spleen, eliminating dampness, and stopping diarrhea.

[0034] Astragalus: Sweet, slightly warm. Enters the spleen and lung meridians. It tonifies qi and raises yang, strengthens the exterior and stops sweating, promotes tissue regeneration and detoxification, and promotes diuresis and reduces edema. It is suitable for spleen and lung qi deficiency, poor appetite, fatigue, shortness of breath, diarrhea, etc.; and for edema caused by qi deficiency, spleen weakness, difficulty urinating, and water retention.

[0035] This invention is based on the guidance of traditional Chinese medicine theory and is the result of numerous preparation experiments and years of practice. It uses Corydalis Rhizome and Acorus Rhizome as the principal herbs, which play a leading role in regulating stomach function, calming the nerves, and promoting gastrointestinal motility. The secondary herbs are Crataegus Pinellia Rhizome, Coptis Rhizome, Angelica Dahurica Root, Dioscorea Rhizome, Ginseng, Atractylodes Rhizome, Bitter Orange Peel, and Poria Cocos. The adjuvant herbs are Boswellia Carterii, Commiphora Myrrha, Tangerine Peel, and Ginger, which play an auxiliary role in enhancing the function of the principal herbs.

[0036] Specifically, Corydalis rhizome is mainly used to treat stomach pain and bloating, helping to harmonize stomach qi and relieve stomach discomfort; Acorus tatarinowii has sedative and gastrointestinal motility-promoting effects, which can help relieve gastrointestinal problems; the synergistic effect of the two helps improve pain related to rumen atony and nerve and muscle dysfunction of the rumen, promotes gastric juice secretion and has anti-ulcer effects; Hawthorn helps improve appetite, promote digestion, and reduce stomach discomfort; Coptis chinensis has anti-inflammatory and antibacterial effects, which can help maintain gastrointestinal health; Angelica dahurica has analgesic and anti-inflammatory effects, which can help relieve pain and discomfort; and Dioscorea opposita is rich in dietary fiber, which is beneficial for… Improving gut health and increasing appetite are beneficial. Ginseng can enhance the immune system, increase physical strength, and help accelerate the recovery process. Atractylodes lancea helps promote gut health, increase appetite, and reduce digestive discomfort. Citrus aurantium helps improve digestive function and reduce bloating. Poria cocos helps balance water and improve gastrointestinal function, which may help relieve gastrointestinal problems. Frankincense and myrrh have anti-inflammatory and antibacterial properties and can relieve pain and inflammation associated with rumen atony in cattle. Tangerine peel helps regulate qi, strengthen the stomach, relieve depression, and reduce bloating. Ginger helps promote digestion, reduce stomach discomfort, and has anti-inflammatory properties.

[0037] This invention addresses the specific symptoms and needs of bovine forestomach atony by formulating a formula that promotes digestion, strengthens the spleen, and replenishes qi to meet the specific needs of bovine forestomach atony. The components work synergistically to maintain gastrointestinal health, improve appetite, promote digestion, reduce bloating, soothe stomach qi, and provide anti-inflammatory and antibacterial effects. It not only helps alleviate discomfort caused by bovine forestomach atony but also helps maintain overall gastrointestinal health, promotes digestion, improves appetite, eliminates potential toxicity and safety concerns, reduces risks during treatment, and ensures treatment safety. The drug combination formula of this invention reflects the comprehensive application principles of traditional Chinese medicine, using a principal-assistant-adjuvant relationship to achieve synergistic effects and provide a more comprehensive therapeutic effect for bovine forestomach atony.

[0038] The method for preparing the above-mentioned pharmaceutical composition includes the following steps:

[0039] (1) After cleaning each raw material, crush and sieve it separately and then mix them evenly;

[0040] (2) Add 2-4 times the mass of 50-98% ethanol solution to the mixture obtained in step (1), let it stand for 1-3 hours, then heat and reflux to extract multiple times, combine the extracts, filter under reduced pressure, concentrate and dry the filtrate for later use.

[0041] Furthermore, in step (2), the heating reflux temperature is 30-60℃, and the extraction time is 100, 60, 40 and 20 minutes respectively.

[0042] Further, in step (2), the extract is concentrated under reduced pressure at 40-80℃ and dried under reduced pressure at 30-60℃ to obtain an extract; then the obtained extract is pulverized and sieved to obtain an ultrafine powder; the ultrafine powder is mixed with excipients and then dried into powder or granulated.

[0043] A formulation for treating bovine forestomach atony, comprising the pharmaceutical composition described above and pharmaceutically acceptable excipients; the dosage form of the formulation is any one of decoction, powder, pill, tablet, mixture, capsule, or granule.

[0044] Example 1

[0045] A pharmaceutical composition for treating bovine forestomach atony includes: 30g of Corydalis Rhizome, 20g of Frankincense, 30g of Myrrh, 40g of Tangerine Peel, 30g of Hawthorn Fruit, 20g of Coptis Rhizome, 30g of Ginger, 20g of Angelica Dahurica Root, 50g of Dioscorea Rhizome, 15g of Ginseng, 30g of Atractylodes Rhizome, 40g of Bitter Orange Peel, 25g of Acorus Rhizome, 40g of Poria Cocos, and 30g of Astragalus Root.

[0046] Its preparation method includes the following steps:

[0047] (1) After cleaning each raw material, crush and sieve it separately and then mix them evenly;

[0048] (2) Add 3 times the mass of 85% ethanol solution to the mixture obtained in step (1), let it stand for 2 hours, and then heat and reflux at 50°C for 4 times, with extraction times of 100, 60, 40 and 20 minutes respectively. Combine the extracts. Then filter under reduced pressure at 50°C. After the filtrate is concentrated and dried, an extract is obtained. The extract is pulverized and sieved to obtain an ultrafine powder. The ultrafine powder is sieved with microcrystalline cellulose, lactose and starch, mixed evenly, and dried into powder for later use.

[0049] Example 2

[0050] The embodiment is different from embodiment 1 in that a pharmaceutical composition for treating bovine foregut atonia comprises: Yuanhu 20g, Muxiang 25g, Mody 35g, Chenpi 40g, Shanzha 35g, Huanglian 25g, Shengjiang 40g, Baizhi 25g, Shanyao 60g, Renshen 20g, Cangzhu 35g, Zhike 40g, Shichangpu 30g, Fuling 35g, Huangqi 40g.

[0051] Embodiment 3

[0052] The embodiment is different from embodiment 1 in that a pharmaceutical composition for treating bovine foregut atonia comprises: Yuanhu 25g, Muxiang 15g, Mody 25g, Chenpi 30g, Shanzha 40g, Huanglian 25g, Shengjiang 30g, Baizhi 15g, Shanyao 45g, Renshen 15g, Cangzhu 15g, Zhike 40g, Shichangpu 30g, Fuling 50g, Huangqi 20g.

[0053] Embodiment 4

[0054] The embodiment is different from embodiment 1 in that a pharmaceutical composition for treating bovine foregut atonia comprises: Yuanhu 30g, Muxiang 20g, Mody 30g, Chenpi 45g, Shanzha 45g, Huanglian 20g, Shengjiang 40g, Baizhi 30g, Shanyao 55g, Renshen 30g, Cangzhu 35g, Zhike 50g, Shichangpu 30g, Fuling 30g, Huangqi 50g.

[0055] Embodiment 5

[0056] The embodiment is different from embodiment 1 in that a pharmaceutical composition for treating bovine foregut atonia comprises: Yuanhu 25g, Muxiang 25g, Mody 35g, Chenpi 50g, Shanzha 40g, Huanglian 25g, Shengjiang 50g, Baizhi 25g, Shanyao 70g, Renshen 20g, Cangzhu 25g, Zhike 40g, Shichangpu 40g, Fuling 40g, Huangqi 30g.

[0057] Embodiment 6

[0058] The embodiment is different from embodiment 1 in that a pharmaceutical composition for treating bovine foregut atonia comprises: Yuanhu 30g, Muxiang 30g, Mody 30g, Chenpi 40g, Shanzha 40g, Huanglian 15g, Shengjiang 25g, Baizhi 15g, Shanyao 30g, Renshen 15g, Cangzhu 20g, Zhike 30g, Shichangpu 20g, Fuling 25g, Huangqi 30g.

[0059] Experimental Example 1

[0060] (1) Experimental subjects: 52 cows with bovine forestomach atony were selected from a large dairy farm in the city from January 2021 to October 2023. The cows were randomly divided into two groups: treatment group and control group, with 26 cases in each group. Among them, there were 26 cases of cows in the treatment group, aged 3-5 years, with an average course of 1-6 months; there were 26 cases of cows in the control group, aged 3-5 years, with an average course of 1-6 months. There was no significant difference in gender, age and disease severity between the two groups (P>0.05).

[0061] (2) Drug administration and observation method:

[0062] Treatment group: The drug powder prepared in Example 1 was given; the drug powder prepared in Example 1 was added to appropriate warm water and stirred thoroughly to ensure uniform mixing, and then fed to the sick cow for drinking, once a day for 3 days.

[0063] Control group: Intravenous injection of 300-500 ml of 10% sodium chloride solution + 100-200 ml of 10% calcium chloride solution + 10-20 ml of 20% aminocaproic acid solution for 3 days.

[0064] (3) Experimental results, see Table 1

[0065] Table 1

[0066]

[0067] As shown in Table 1, the drug administration method of the present application is simple and convenient to use, and has good effect on bovine forestomach atony. After 3 days of administration, the clinical symptoms of the sick cow with forestomach atony improved significantly. Compared with the existing combination of western medicine injection and oral administration, the treatment is simple and the treatment effect is better, with a cure rate of 96.2%, which is significantly higher than that of the control group treated with western medicine.

[0068] Typical case data:

[0069] 1. The sick cow is a 5-year-old cow. The symptoms are as follows: the sick cow is a 5-year-old cow, and has had symptoms of indigestion in recent days. The sick cow has been using roughage with high fiber and low nutritional content such as straw, wheat straw and bean straw for a long time, which has led to a monotonous and poor state of the digestive function of the sick cow.

[0070] The sick cow showed a decrease in appetite, a significant decrease or stop in rumination, a decrease in mental state, and a feeling of fatigue and inactivity. Physiological indicators such as body temperature, respiration and pulse remained normal, but rumen contraction force was weakened, peristalsis frequency was reduced, and rumen peristalsis sound was low. The lactation rate decreased, and occasionally there were belching, sour smell, constipation, hard and dark-colored feces.

[0071] Treatment scheme: In the case of treating the digestive disorder of the cattle, especially the problem caused by long-term feeding of roughage with high fiber and low nutrient content, the drug of Example 2 of the present application is used for treatment. After the implementation of the treatment scheme, the symptoms of the sick cattle gradually ease. The mental state of the sick cattle gradually recovers, and the appetite begins to gradually increase. The ruminant action gradually returns to normal. The physiological indicators such as rumen contraction force and peristalsis frequency gradually recover, and the omental rumbling sound becomes clear. At the same time, the milk yield of the sick cattle also gradually increases, and the symptoms of belching and sour smell gradually decrease. The constipation problem is also alleviated, and the feces becomes normal.

[0072] Prevention of the disease: Avoid long-term feeding of roughage with high fiber and low nutrient content, reasonably adjust the feed, and avoid sudden change of feed types. Ensure sufficient water supply, enhance exercise, and maintain clean and ventilated cowshed.

[0073] 2, The sick cattle are dairy cows, age: 4 years old; symptom performance: the sick cattle have digestive disorder symptoms. The cowshed environment is dark and humid, crowded and not ventilated, and the sanitary condition is poor. Lack of sufficient exercise and sunlight leads to reduced nervous reactivity, and the digestive tract of the cattle is in a relaxed state, which is easy to cause the disease. The sick cattle show decreased appetite, decreased mental state, and slowed ruminant action, and show symptoms of fatigue and inactivity. In terms of physiological indicators, the body temperature, respiration, and pulse remain normal, but the rumen contraction force is weakened, the peristalsis frequency is reduced, and the omental rumbling sound is low. The milk yield of the cattle decreases, and occasionally shows belching, sour smell, and also has constipation and dry and hard dark feces.

[0074] Treatment scheme: Based on the symptoms of the sick cattle and the feeding environment problem, the drug of Example 3 of the present application is used for treatment. After the implementation of the treatment scheme, the symptoms of the sick cattle gradually ease. The mental state of the sick cattle gradually recovers, and the appetite begins to gradually increase. The ruminant action gradually returns to normal. The physiological indicators such as rumen contraction force and peristalsis frequency gradually recover, and the omental rumbling sound becomes clear. At the same time, the milk yield of the sick cattle also gradually increases, and the symptoms of belching and sour smell gradually decrease. The constipation problem is also alleviated, and the feces becomes normal.

[0075] Prevention of the disease: In order to prevent the recurrence of similar cases, the management of the feeding environment should be strengthened to ensure sufficient ventilation and sunlight, provide sufficient exercise space, and maintain a dry and clean cowshed environment. In addition, the feed formula is regularly checked and adjusted to ensure that the cattle obtain balanced nutrition and diet, thereby improving the immunity and digestive system function of the cattle.

[0076] The above is only a preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A pharmaceutical composition for treating bovine forestomach atony, characterized in that, By weight, it consists of the following ingredients: Corydalis rhizome 15-30 parts, Frankincense 15-30 parts, Myrrh 25-45 parts, Tangerine peel 30-60 parts, Hawthorn 24-45 parts, Coptis rhizome 15-30 parts, Ginger 15-60 parts, Angelica dahurica 15-30 parts, Dioscorea opposita 30-90 parts, Ginseng 15-30 parts, Atractylodes lancea rhizome 15-60 parts, Citrus aurantium 30-60 parts, Acorus tatarinowii rhizome 20-45 parts, Poria cocos 20-60 parts, Astragalus membranaceus rhizome 20-60 parts.

2. The pharmaceutical composition for treating bovine forestomach atony according to claim 1, characterized in that, By weight, it consists of the following ingredients: Corydalis rhizome 20-30 parts, frankincense 20-25 parts, myrrh 30-40 parts, dried tangerine peel 35-50 parts, hawthorn 25-35 parts, Coptis chinensis 20-25 parts, ginger 20-50 parts, angelica dahurica 20-25 parts, yam 40-80 parts, ginseng 15-25 parts, Atractylodes lancea rhizome 20-50 parts, immature bitter orange peel 35-50 parts, acorus tatarinowii rhizome 25-30 parts, poria cocos 30-50 parts, and astragalus membranaceus 30-50 parts.

3. The pharmaceutical composition for treating bovine forestomach atony according to claim 2, characterized in that, By weight, it consists of the following ingredients: Corydalis rhizome 30 parts, frankincense 20 parts, myrrh 30 parts, dried tangerine peel 40 parts, hawthorn 30 parts, Coptis chinensis 20 parts, ginger 30 parts, angelica dahurica 20 parts, yam 50 parts, ginseng 15 parts, Atractylodes lancea 30 parts, immature bitter orange peel 40 parts, Acorus tatarinowii 25 parts, Poria cocos 40 parts, and Astragalus membranaceus 30 parts.

4. The pharmaceutical composition for treating bovine forestomach atony according to claim 2, characterized in that, By weight, it consists of the following ingredients: Corydalis rhizome 20 parts, frankincense 25 parts, myrrh 35 parts, dried tangerine peel 40 parts, hawthorn 35 parts, Coptis chinensis 25 parts, ginger 40 parts, angelica dahurica 25 parts, yam 60 parts, ginseng 20 parts, Atractylodes lancea 35 parts, immature bitter orange peel 40 parts, acorus tatarinowii 30 parts, poria cocos 35 parts, and astragalus membranaceus 40 parts.

5. A method for preparing a pharmaceutical composition according to any one of claims 1-4, characterized in that, Includes the following steps: (1) After cleaning each raw material, crush and sieve them separately and then mix them evenly; (2) Add 2-4 times the mass of ethanol solution to the mixture obtained in step (1), let it stand for 1-3 hours, heat and reflux to extract 4 times, combine the extracts, filter under reduced pressure, concentrate and dry the filtrate for later use.

6. The method for preparing the pharmaceutical composition according to claim 5, characterized in that, In step (2), the heating reflux temperature is 30-60℃ and the extraction time interval is 20-100 minutes.

7. The method for preparing the pharmaceutical composition according to claim 5, characterized in that, In step (2), the extract is concentrated under reduced pressure at 40-80℃ to form an extract.

8. The method for preparing the pharmaceutical composition according to claim 7, characterized in that, The obtained extract is pulverized and sieved to obtain ultrafine powder; the ultrafine powder is mixed with excipients and then dried into powder or granulated.

9. A preparation for treating bovine forestomach atony, characterized in that, It is composed of the following raw materials: the pharmaceutical composition according to any one of claims 1-4, and pharmaceutically acceptable excipients.

10. The preparation for treating bovine forestomach atony according to claim 9, characterized in that, The dosage form of the preparation is any one of decoction, powder, pill, tablet, mixture, capsule, or granule.

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