A method for preparing a coiled peptide gradient scaffold carrying exosomes, and products and uses thereof

By preparing a rolled peptide gradient scaffold carrying exosomes, and utilizing the gradient structure and peptide-modified rolled scaffold, the problems of nerve regeneration and microenvironment regulation after spinal cord injury were solved, and significant spinal cord injury recovery effects were achieved.

CN117919498BActive Publication Date: 2026-06-19ZHEJIANG UNIV
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Filing Date
2023-12-19
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing technologies have limited effectiveness in promoting nerve regeneration and microenvironment regulation after spinal cord injury, and the lack of effective treatment methods leads to a long disease course and a decline in quality of life after injury.

Method used

A roll-shaped peptide gradient scaffold carrying exosomes was prepared. The roll-shaped structure with gradient changes was formed by photocrosslinking. Combined with multilayer structure and peptide modification, the exosomes were carried to promote nerve regeneration and regulate the local microenvironment, and the anti-inflammatory and anti-apoptotic effects of exosomes were utilized.

Benefits of technology

It significantly promoted nerve regeneration after spinal cord injury, reduced neuronal apoptosis, improved the local immune microenvironment, and achieved long-term spinal cord injury recovery without the need for additional drug support.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN117919498B_ABST
    Figure CN117919498B_ABST
Patent Text Reader

Abstract

This invention discloses a method for preparing a roll-shaped peptide gradient scaffold carrying exosomes, comprising: modifying a scaffold matrix with peptides to obtain a peptide-modified scaffold matrix; curing the peptide-modified scaffold matrix by photocrosslinking according to a distance gradient to obtain a peptide gradient scaffold; processing the peptide gradient scaffold into a roll-shaped structure with the peptide concentration gradient direction as the axis to obtain a roll-shaped peptide gradient gel scaffold; and loading the roll-shaped peptide gradient gel scaffold with exosomes to obtain a roll-shaped peptide gradient scaffold carrying exosomes. This invention also discloses the roll-shaped peptide gradient scaffold carrying exosomes obtained by the above preparation method and its application in the preparation of products for treating spinal cord injuries. The preparation method is simple, and the resulting scaffold possesses excellent function in promoting spinal cord injury recovery.
Need to check novelty before this filing date? Find Prior Art