Traditional Chinese medicine composition for treating reflux esophagitis and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating reflux esophagitis. The composition is prepared by extracting the following traditional Chinese medicine raw materials in parts by weight: 15-25 parts of gentian, 20-30 parts of selfheal, 18-22 parts of chrysanthemum, 20-30 parts of mint, 15-25 parts of scutellaria, 12-16 parts of gardenia, 15-25 parts of peony bark, etc. The composition can clear liver fire, clear stomach fire, soothe the liver and harmonize the stomach, promote blood circulation and soften the liver, strengthen the spleen and replenish qi, and reduce stomach qi and lung qi, thereby jointly treating reflux esophagitis of liver and stomach stagnation heat type with significant effect. The invention also discloses a preparation method thereof.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating reflux esophagitis and a preparation method thereof. Background Art

[0002] Reflux esophagitis is an inflammatory lesion of the esophagus caused by the reflux of gastric and duodenal contents into the esophagus. Endoscopically, it manifests as damage to the esophageal mucosa, namely, esophageal erosion and / or esophageal ulcers. Reflux esophagitis can occur in people of all ages, with the incidence in adults increasing with age. The incidence is higher in Western countries and lower in Asia. This regional difference may be related to genetic and environmental factors. However, the global incidence has been on the rise over the past two decades. The elderly, obese individuals, smokers, alcohol users, and those experiencing high levels of mental stress are at high risk of reflux esophagitis.

[0003] Traditional Chinese Medicine (TCM) categorizes acid regurgitation as "regurgitation of acid," "nausea," "epigastric pain," "plum pit qi," and "chest pain." The Suwen Zhizhen Yao Da Lun (The Great Treatise on the Essential Essentials of the Suwen) first identified the symptom of acid regurgitation and pointed out its association with pathogenic heat. Ming Dynasty physicians further understood the condition. Tang Shouyuan's Yilin Shengmo (The Guide to Medicine) noted the distinction between acid regurgitation and acid vomiting, stating, "Those who swallow acid...those who vomit acid vomit sour and bitter water." Traditional Chinese Medicine believes that reflux esophagitis often suffers from acid reflux, and severe cases may develop dysphagia. The disease is often caused by emotional distress, leading to liver qi stagnation and the transformation of qi into fire; anger damaging the liver, liver stagnation invading the spleen, liver fire attacking the stomach and damaging the esophagus; damp heat in the spleen and stomach, exogenous cold and heat imbalances, the six evil toxins invading the esophagus, qi stagnation and blood stasis, which, over time, transform into heat, causing flesh decay and pus; or spleen and stomach weakness, irregular diet, a preference for spicy and greasy foods, excessive smoking and alcohol consumption, gastrointestinal heat accumulation, loss of fluid distribution, internal generation of phlegm, which rises with qi and blocks the airway; or long-term illness leading to middle-jiao deficiency and cold, all of which can lead to dysphagia. Currently, there is no effective treatment. Summary of the Invention

[0004] In order to address the deficiencies of the prior art, the present invention provides a traditional Chinese medicine composition having good efficacy, high cure rate, and the ability to effectively treat reflux esophagitis of the liver and stomach heat type, and a preparation method thereof.

[0005] The technical solution of the present invention is: a traditional Chinese medicine composition for treating reflux esophagitis, which is prepared by extracting the following traditional Chinese medicine raw materials in parts by weight: 15-25 parts of gentian, 20-30 parts of selfheal, 18-22 parts of chrysanthemum, 20-30 parts of mint, 15-25 parts of scutellaria, 12-16 parts of gardenia, 15-25 parts of moutan bark, 18-22 parts of trichosanthes, 15-25 parts of bupleurum, 10-20 parts of white peony root, 20-30 parts of hawthorn, 15-25 parts of cyperus, 18-22 parts of ligusticum, 15-25 parts of angelica, 20-30 parts of yam, 20-30 parts of ginseng, 15-25 parts of codonopsis, 12-16 parts of pseudoginseng, 12-16 parts of pinellia, 15-25 parts of inula flower, 18-22 parts of perilla seed, and 18-22 parts of radish seed.

[0006] The traditional Chinese medicine composition for treating reflux esophagitis is prepared by extracting the following traditional Chinese medicine raw materials in parts by weight: 20 parts of gentian, 25 parts of selfheal, 20 parts of chrysanthemum, 25 parts of mint, 20 parts of scutellaria, 14 parts of gardenia, 20 parts of moutan bark, 20 parts of trichosanthes, 20 parts of bupleurum, 15 parts of white peony root, 25 parts of hawthorn, 20 parts of cyperus, 20 parts of ligusticum, 20 parts of angelica, 25 parts of yam, 25 parts of ginseng, 20 parts of codonopsis, 14 parts of pseudoginseng, 14 parts of pinellia, 20 parts of inula flower, 20 parts of perilla seed, and 20 parts of radish seed.

[0007] The preparation method of the traditional Chinese medicine composition for treating reflux esophagitis comprises the following steps:

[0008] (1) Select Chinese medicinal materials and wash them with water;

[0009] (2) adding water and soaking for 2-4 hours according to the weight ratio of the Chinese medicinal raw material to water of 1:8-10 times, then boiling, keeping boiling for 2-3 hours, filtering out the residue, and then concentrating to 10-20% of the weight of the original Chinese medicinal raw material to obtain a concentrated solution;

[0010] (3) cooling the concentrated solution to room temperature to obtain a first concentrated solution, adding edible alcohol to mix the solution into a mixed solution containing 50-60% alcohol concentration, refrigerating the mixed solution at 2-8° C. for 20-30 hours, and collecting the supernatant;

[0011] (4) concentrating the supernatant in step (3) under reduced pressure to 50-60% of the weight of the first concentrated solution to obtain a second concentrated solution;

[0012] (5) heating and concentrating the second concentrated liquid to a relative density of 1.28-1.3 at 25° C., and drying to obtain an extract powder;

[0013] (6) The extract powder obtained in step (5) is added with excipients to prepare a solid preparation.

[0014] In the preparation method of the traditional Chinese medicine composition for treating reflux esophagitis, the temperature for the reduced pressure concentration in step (4) is 60-80°C, and the temperature for the drying in step (5) is 60-80°C.

[0015] The traditional Chinese medicine composition for treating reflux esophagitis has a solid preparation in the preparation method in the form of granules, tablets or capsules.

[0016] The invention relates to an application of the traditional Chinese medicine composition for treating reflux esophagitis in preparing a medicine for treating reflux esophagitis.

[0017] The traditional Chinese medicine composition for treating reflux esophagitis is used in preparing medicine for treating reflux esophagitis, wherein the reflux esophagitis is of the liver-stomach heat stagnation type.

[0018] The above-mentioned Chinese medicine raw materials all meet the pharmacopoeia standards.

[0019] Reflux esophagitis, known in Traditional Chinese Medicine as "acid regurgitation," is described in the Suwen (Suwen) Zhizhen Yao Dalun (Zhenzhen Yao Dalun) as "all forms of acid vomiting, sudden and urgent discharge, are all symptoms of heat," indicating heat in the stomach meridian. This can also be caused by internal liver fire invading the stomach, brewing into acid. However, Chao Yuanfang's Zhubing Yuanhou Lun (Zhubingyuanhou) states, "Vinegar belching is caused by stagnant phlegm in the upper burner and coldness in the spleen and stomach, which prevents digestion. Undigested food leads to bloating and qi reflux, resulting in belching, acid regurgitation, and a vinegary breath." This suggests that there are differing viewpoints on the pathogenesis of reflux esophagitis. The Traditional Chinese Medicine section of the "Chinese Multidisciplinary Consensus on the Diagnosis and Treatment of Gastroesophageal Reflux Disease" categorizes this condition into five syndromes: liver-stomach heat stagnation syndrome, gallbladder heat invading the stomach syndrome, middle-deficiency qi reflux syndrome, qi stagnation and phlegm obstruction syndrome, and a mixed syndrome of cold and heat. The present invention believes that it is necessary to first distinguish between cold and heat. Li Yongcui of the Qing Dynasty stated in his book "Zhengzhi Huibu·Swallowing Acid": "Generally speaking, when heat accumulates in the middle burner and becomes heat over a long period of time, it is originally transformed from fire, and the resulting acid is the heat of acid. If cold invades the stomach, it will instantly become acid. There is no stagnant heat, but it is transformed by cold, which is the cold of acid." In clinical practice, liver-stomach stagnation and heat are the most common symptoms, with symptoms such as noisy breathing, burning pain behind the sternum, and acid reflux; secondary symptoms include fullness in the flanks, irritability, dry mouth and bitter taste, and constipation; red tongue and wiry pulse. Pathogenesis analysis: Regurgitation of acid, epigastric fullness, bitter mouth and dry throat are caused by the combination of stagnant heat and the failure of stomach turbidity to descend; irritability and stagnation and pain in the flanks are caused by emotional disharmony, internal stagnation of liver fire, and failure of stomach harmony to descend. A red tongue, yellow fur, and wiry pulse are signs of liver-stomach stagnation and heat. Generally, liver-stomach stagnation and heat will cause acid vomiting for a long time. If the method of simply soothing the liver and stomach is used, it will easily damage the vital energy. The present invention treats reflux esophagitis of liver-stomach stagnation and heat type by adopting the following treatment principles: 1. "All symptoms of qi reflux and upward rushing are caused by fire" and "All symptoms of acid vomiting... are caused by heat", pointing out that all symptoms of qi reflux and upward rushing, vomiting and acid vomiting are caused by "fire-heat" evil energy. Due to liver and stomach heat, it is advisable to clear liver fire and stomach fire first. Second, due to emotional distress, the liver is not smooth, the liver and stomach qi are not harmonious, the liver wood takes over the stomach, and the stomach loses harmony and descends, so the method of soothing the liver and harmonizing the stomach is adopted. Third, due to liver qi stagnation, the source of the disease lies in the qi mechanism, so it is advisable to promote qi and relieve depression, so that qi and blood can circulate, and phlegm, fire and dampness can be resolved by themselves. Fourth, due to irregular diet, overeating, food stagnation, blocking the rise and fall of spleen and stomach qi, wood stagnation and earth congestion, qi reverse stagnation and heat, so the method of strengthening the spleen and replenishing qi is adopted. Fifth, the lung restrains the liver, that is, metal overcomes wood. If the lung qi is clear, it can suppress the rise of liver yang, so the method of lowering lung qi is adopted. At the same time, the stomach fails to descend harmoniously, the qi mechanism is not smooth, stagnation turns into fire, and the dysfunction of the five internal organs can damage the stomach qi, so the stomach qi should be lowered at the same time.

[0020] The present invention adopts gentian, selfheal, chrysanthemum and mint to clear liver fire, scutellaria, gardenia, peony bark and trichosanthes to clear stomach fire, which are all monarch drugs; bupleurum, white peony root and hawthorn to soothe liver and harmonize the stomach, cyperus, ligusticum and angelica to promote blood circulation and soften the liver, which are all minister drugs; yam, ginseng, codonopsis and pseudoginseng to strengthen the spleen and replenish qi, which are adjuvant drugs; pinellia and inulin to reduce stomach qi, perilla seed and radish seed to reduce lung qi, which are all guiding drugs. Gentiana scabra, Prunella vulgaris, chrysanthemum, mint, scutellaria baicalensis, gardenia jasminoides, peony bark, trichosanthes kirilowii, bupleurum, white peony root, hawthorn, cyperus rotundus, ligusticum chuanxiong, angelica sinensis, yam, ginseng, codonopsis pilosula, pseudostellaria, pinellia, inula flower, perilla seed, radish seed can clear liver fire, clear stomach fire, soothe the liver and harmonize the stomach, promote blood circulation and soften the liver, strengthen the spleen and replenish qi, reduce stomach qi and lung qi, and together treat liver and stomach heat type reflux esophagitis with significant results. DETAILED DESCRIPTION

[0021] Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiments are only used to illustrate the present invention and are not used in limiting the scope of the present invention.In addition, should be understood that after reading the content of the present invention record, those skilled in the art can make various changes or modifications to the present invention, but these equivalent forms fall within the scope limited by the application's appended claims equally.

[0022] Example 1: Take 20g of Gentiana scabra, 25g of Prunella Vulgaris, 20g of Chrysanthemum, 25g of Mentha, 20g of Scutellaria baicalensis, 14g of Gardenia jasminoides, 20g of Moutan Cortex, 20g of Trichosanthes kirilowii, 20g of Bupleurum chinense, 15g of White Peony Root, 25g of Crataegus pinnatifida, 20g of Cyperus rotundus, 20g of Chuanxiong, 20g of Angelica sinensis, 25g of Chinese Yam, 25g of Ginseng, 20g of Codonopsis pilosula, 14g of Pseudostellaria baicalensis, 14g of Pinellia ternata, 20g of Inula flower, 20g of Perilla seed, and 20g of Radish seed. The preparation method comprises the following steps:

[0023] (1) Select Chinese medicinal materials and wash them with water;

[0024] (2) adding water and soaking for 3 hours according to the ratio of Chinese medicinal raw materials to water of 1:9 times by weight, then boiling, keeping boiling for 2 hours, filtering out the residue, and then concentrating to 10-20% of the weight of the original Chinese medicinal raw materials to obtain a concentrated solution;

[0025] (3) Cooling the concentrated solution to room temperature to obtain a first concentrated solution, adding edible alcohol to mix the solution into a mixture containing 50-60% alcohol concentration, refrigerating the mixture at 4° C. for 25 hours, and collecting the supernatant;

[0026] (4) concentrating the supernatant in step (3) under reduced pressure to 55% of the weight of the first concentrated solution to obtain a second concentrated solution, wherein the temperature for the reduced pressure concentration is 70° C.;

[0027] (5) heating and concentrating the second concentrated liquid to a relative density of 1.28 at 25°C, and drying to obtain an extract powder at a drying temperature of 70°C;

[0028] (6) The extract powder obtained in step (5) is added with dextrin to prepare granules.

[0029] Example 2: Take 25g of gentian, 20g of selfheal, 22g of chrysanthemum, 20g of mint, 25g of scutellaria, 12g of gardenia, 25g of moutan bark, 18g of trichosanthes, 25g of bupleurum, 10g of white peony root, 30g of hawthorn, 15g of cyperus, 22g of ligusticum, 15g of angelica, 30g of yam, 20g of ginseng, 25g of codonopsis, 12g of pseudoginseng, 16g of pinellia, 15g of inulin, 22g of perilla seed, and 18g of radish seed, and the preparation method comprises the following steps:

[0030] (1) Select Chinese medicinal materials and wash them with water;

[0031] (2) adding water and soaking for 2 hours according to the weight ratio of the Chinese medicinal raw materials to water of 1:10, then boiling, keeping boiling for 3 hours, filtering out the residue, and then concentrating to 10% of the weight of the original Chinese medicinal raw materials to obtain a concentrated solution;

[0032] (3) Cooling the concentrated solution to room temperature to obtain a first concentrated solution, adding edible alcohol to mix the solution to a mixture containing 60% alcohol concentration, refrigerating the mixture at 2° C. for 30 hours, and collecting the supernatant;

[0033] (4) concentrating the supernatant in step (3) under reduced pressure to 50% of the weight of the first concentrated solution to obtain a second concentrated solution, wherein the temperature for the reduced pressure concentration is 60° C.;

[0034] (5) heating and concentrating the second concentrated liquid to a relative density of 1.3 at 25°C, and drying to obtain an extract powder at a drying temperature of 80°C;

[0035] (6) The extract powder obtained in step (5) is added with starch to prepare tablets.

[0036] Example 3: Take 15g of Gentiana scabra, 30g of Prunella vulgaris, 18g of Chrysanthemum, 30g of Menthol, 15g of Scutellaria baicalensis, 16g of Gardenia jasminoides, 15g of Moutan bark, 22g of Trichosanthes kirilowii, 15g of Bupleurum chinense, 20g of White Peony Root, 20g of Crataegus pinnatifida, 25g of Cyperus rotundus, 18g of Ligusticum chuanxiong, 25g of Angelica sinensis, 20g of Chinese Yam, 30g of Ginseng, 15g of Codonopsis pilosula, 16g of Pseudostellariae pseudoginseng, 12g of Pinellia ternata, 25g of Inula flower, 18g of Perilla seed, and 22g of Radish seed, and the preparation method comprises the following steps:

[0037] (1) Select Chinese medicinal materials and wash them with water;

[0038] (2) adding water and soaking for 4 hours according to the weight ratio of the Chinese medicinal raw materials to water of 1:8, then boiling and keeping boiling for 2 hours, filtering out the residue, and then concentrating to 20% of the weight of the original Chinese medicinal raw materials to obtain a concentrated solution;

[0039] (3) Cooling the concentrated solution to room temperature to obtain a first concentrated solution, adding edible alcohol to mix the solution to a mixture containing 50% alcohol concentration, refrigerating the mixture at 8° C. for 20 hours, and collecting the supernatant;

[0040] (4) concentrating the supernatant in step (3) under reduced pressure to 60% of the weight of the first concentrated solution to obtain a second concentrated solution, wherein the temperature for the reduced pressure concentration is 80° C.;

[0041] (5) heating and concentrating the second concentrated liquid to a relative density of 1.28 at 25°C, and drying to obtain an extract powder at a drying temperature of 60°C;

[0042] (6) The extract powder obtained in step (5) is added with dextrin to prepare capsules.

[0043] Example 4: Clinical study of the present invention on reflux esophagitis of liver and stomach heat type

[0044] Case selection: 100 outpatients from the Shenzhen Hospital of Guangzhou University of Chinese Medicine (Futian) were randomly divided into two groups of 50 each. The control group consisted of 24 males and 26 females, aged 24-63 years, with a disease course of 1-5 years. The treatment group consisted of 27 males and 23 females, aged 22-65 years, with a disease course of 2-5 years. The general information of the two groups was compared (P>0.05).

[0045] Western medicine diagnostic criteria: Refer to the "2014 Chinese Gastroesophageal Reflux Disease Expert Consensus", with symptoms such as heartburn, upper abdominal pain, bloating, belching, etc., esophageal pH monitoring shows excessive acid reflux, and endoscopy shows the presence of reflux esophagitis.

[0046] Traditional Chinese Medicine (TCM) diagnostic criteria: Refer to the "2017 Consensus on the Diagnosis and Treatment of Gastroesophageal Reflux Disease Using Integrated Traditional Chinese and Western Medicine." The diagnosis is liver-stomach stagnation and heat syndrome. The primary symptoms are noisy breathing, burning pain behind the sternum, and acid reflux. Secondary symptoms include fullness in the flanks, irritability, dry and bitter mouth, and constipation. The tongue is red and the pulse is stringy.

[0047] Inclusion criteria: ① patients were informed and signed consent forms; ② met the diagnostic criteria; ③ complete clinical data; ④ aged over 18 years.

[0048] Exclusion criteria: ① History of abdominal surgery such as duodenum, stomach, or esophagus surgery; ② Drug abuse or alcoholism; ③ Allergy to the drugs used in the study; ④ Poor compliance and inability to fully follow the doctor's instructions for medication; ⑤ Pregnancy or lactation; ⑥ Use of acid-suppressing drugs in the past week.

[0049] Treatment method: The control group took Zuojin Wan (Beijing Tongrentang Pharmaceutical Co., Ltd., national medicine standard Z11020861) orally, 6 grams at a time, twice a day. The first group of the present invention took the granules prepared in Example 1, with a daily dosage of 20g of Gentiana scabra, 25g of Prunella vulgaris, 20g of Chrysanthemum, 25g of Mentha, 20g of Scutellaria baicalensis, 14g of Gardenia jasminoides, 20g of Moutan bark, 20g of Trichosanthes kirilowii, 20g of Bupleurum chinense, 15g of White Peony Root, 25g of Crataegus pinnatifida, 20g of Cyperus rotundus, 20g of Chuanxiong, 20g of Angelica sinensis, 25g of Chinese Yam, 25g of Ginseng, 20g of Codonopsis pilosula, 14g of Pseudostellariae pseudoginseng, 14g of Pinellia ternata, 20g of Inula flower, 20g of Perilla seed, and 20g of Radish seed, prepared into granules, and taken three times a day. Both groups were treated continuously for 8 weeks.

[0050] Clinical efficacy: A 95% or greater reduction in the liver-stomach stagnation-heat syndrome score and the disappearance of reflux symptoms constitutes clinical cure. A 70%-94% reduction in the liver-stomach stagnation-heat syndrome score and the near-disappearance of reflux symptoms constitute marked efficacy. A 30%-69% reduction in the liver-stomach stagnation-heat syndrome score and a reduction in reflux symptoms compared to pre-treatment are considered effective. Anything below the "effective" standard is considered ineffective.

[0051] TCM syndrome score: The three main symptoms of noisy stomach, burning pain behind the sternum, and acid reflux were evaluated, with each score being 0, 1, 2, and 3 points according to normal, mild, moderate, and severe, respectively.

[0052] Gastrointestinal hormone levels: 3 mL of fasting venous blood was collected in the morning before and after treatment to detect motilin and gastrin levels using enzyme-linked immunosorbent assay.

[0053] Results: The comparison of clinical efficacy between the two groups is shown in Table 1, and the comparison of gastrointestinal hormone levels between the two groups before and after treatment is shown in Table 2.

[0054] Table 1 Comparison of clinical efficacy between the two groups

[0055] Group get well Significant effect efficient invalid Effectiveness (%) control group 10 21 7 12 76 Example 1 group 17 25 5 3 94

[0056] Table 2 Comparison of gastrointestinal hormone levels in the two groups before and after treatment

[0057]

[0058] Note: Compared with the group before treatment, * P<0.05.

[0059] Conclusion: The clinical efficacy of the present invention in treating reflux esophagitis of liver-stomach heat type is higher than that of the control group Zuojin Wan group, and the gastrointestinal hormone levels are significantly improved before and after treatment, indicating that the present invention can effectively treat reflux esophagitis of liver-stomach heat type.

[0060] While embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions, and variations may be made to these embodiments without departing from the principles and spirit of the invention, and that the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating reflux esophagitis, characterized in that: The invention is prepared by extracting the following Chinese medicinal raw materials in parts by weight: 15-25 parts of gentian, 20-30 parts of selfheal, 18-22 parts of chrysanthemum, 20-30 parts of mint, 15-25 parts of scutellaria, 12-16 parts of gardenia, 15-25 parts of moutan bark, 18-22 parts of trichosanthes, 15-25 parts of bupleurum, 10-20 parts of white peony root, 20-30 parts of hawthorn, 15-25 parts of cyperus, 18-22 parts of ligusticum, 15-25 parts of angelica, 20-30 parts of yam, 20-30 parts of ginseng, 15-25 parts of codonopsis, 12-16 parts of pseudoginseng, 12-16 parts of pinellia, 15-25 parts of inula flower, 18-22 parts of perilla seed and 18-22 parts of radish seed.

2. The Chinese medicine composition for treating reflux esophagitis according to claim 1, characterized in that: The invention is prepared by extracting the following Chinese medicinal raw materials in parts by weight: 20 parts of gentian, 25 parts of selfheal, 20 parts of chrysanthemum, 25 parts of mint, 20 parts of scutellaria, 14 parts of gardenia, 20 parts of peony bark, 20 parts of trichosanthes, 20 parts of bupleurum, 15 parts of white peony root, 25 parts of hawthorn, 20 parts of cyperus, 20 parts of ligusticum, 20 parts of angelica, 25 parts of yam, 25 parts of ginseng, 20 parts of codonopsis, 14 parts of pseudoginseng, 14 parts of pinellia, 20 parts of inula flower, 20 parts of perilla seed and 20 parts of radish seed.

3. The Chinese medicine composition for treating reflux esophagitis according to any one of claims 1-2, characterized in that: The preparation method comprises the following steps: (1) Select Chinese medicinal materials and wash them with water; (2) Add water and soak for 2-4 hours according to the weight ratio of Chinese medicinal raw materials to water of 1:8-10 times, then boil and keep boiling for 2-3 hours, filter out the residue, and then concentrate to 10-20% of the weight of the original Chinese medicinal raw materials to obtain a concentrated solution; (3) Cooling the concentrated solution to room temperature to obtain a first concentrated solution, adding edible alcohol, and mixing to form a mixed solution containing 50-60% alcohol concentration, refrigerating the mixed solution at 2-8°C for 20-30 hours, and taking the supernatant; (4) Concentrating the supernatant in step (3) under reduced pressure to 50-60% of the weight of the first concentrated solution to obtain a second concentrated solution; (5) The second concentrated liquid is heated and concentrated to a relative density of 1.28-1.3 at 25°C, and then dried to obtain an extract powder; (6) The extract powder obtained in step (5) is added with excipients to prepare a solid preparation.

4. The Chinese medicine composition for treating reflux esophagitis according to claim 3, characterized in that: In the preparation method, the temperature for the reduced pressure concentration in step (4) is 60 to 80° C., and the temperature for the drying in step (5) is 60 to 80° C.

5. The Chinese medicine composition for treating reflux esophagitis according to claim 3, characterized in that: The dosage form of the solid preparation in the preparation method includes one of granules, tablets or capsules.

6. Use of the traditional Chinese medicine composition for treating reflux esophagitis according to claim 1 in preparing a medicine for treating reflux esophagitis.

7. Use of the traditional Chinese medicine composition for treating reflux esophagitis according to claim 1 in preparing a drug for treating reflux esophagitis, characterized in that: Reflux esophagitis is a liver-stomach heat type.

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