A composition with long-lasting anti-wrinkle, skin elasticity and firming efficacy and its preparation method and application

Abstract

The application discloses a composition with long-acting anti-wrinkle, skin elasticity improvement and skin tightening effects, a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition comprises the following efficacy components: Schizosaccharomyces pombe ferment lysate, hydroxypropyl tetrahydropyrane triol, lactose, whey protein, lactic acid, Lactarius volemus extract and palm leaf tree extract. The eye cream prepared by using the composition has very significant long-acting anti-wrinkle, skin elasticity improvement and skin tightening effects. After 28 days of use, the R2 value of skin elasticity at the corner of the eye is increased by more than 20%, the R0 value of total skin stretching displacement is decreased by more than 40%, the proportion of wrinkle area is decreased by more than 15%, and the wrinkle depth is decreased by more than 27%. The effect after 28 days of use is also significantly better than that after 14 days of use.

Description

Technical Field

[0001] This invention relates to the field of skincare technology, specifically to a composition with long-lasting anti-wrinkle, skin elasticity-improving and firming effects, its preparation method and application. Background Technology

[0002] Skin aging is a natural process. With age, environmental factors, and lifestyle influences, skin gradually loses its elasticity and firmness, leading to fine lines, wrinkles, and sagging. The skin around the eyes is the thinnest on the body, the most frequently used area, and the area most prone to stretching during makeup application, making it very susceptible to wrinkles. Therefore, research on cosmetics with anti-wrinkle and firming effects for the eye area is currently a hot research topic. In its previous research, the applicant company disclosed an anti-wrinkle and firming eye cream. This cream uses a combination of six ingredients: Bifida ferment lysate, β-glucan, hydroxypropyl tetrahydropyranotriol, Centella asiatica extract / Polygonum cuspidatum root extract / Scutellaria baicalensis root extract / Tea leaf extract / Glycyrrhiza glabra extract / Chamomile extract / Rosemary leaf extract, Agrimonia pilosa extract / Ampelopsis japonica leaf extract, and lactose / whey protein / lactic acid. It achieved a significant reduction in skin firmness R0 value and wrinkle reduction, but its effectiveness still needs improvement. Summary of the Invention

[0003] In view of the shortcomings of the prior art, the purpose of this invention is to provide a composition with long-lasting anti-wrinkle, skin elasticity-improving and firming effects, as well as its preparation method and application.

[0004] The objective of this invention is achieved through the following technical solution:

[0005] In a first aspect, the present invention provides a composition having long-lasting anti-wrinkle, skin elasticity-improving and firming effects, comprising the following active ingredients: Bifida ferment lysate, hydroxypropyl tetrahydropyranotriol, lactose, whey protein, lactic acid, mushroom extract, and palm-leaf extract.

[0006] Preferably, the composition having long-lasting anti-wrinkle, skin elasticity-improving and firming effects specifically comprises the following raw material components in parts by weight: 2-6 parts of Bifida Ferment Lysate / Phenoxyethanol / Sodium Benzoate, 1-3 parts of Butylene Glycol / Hydroxypropyl Tetrahydropyranotriol / Water, 0.5-1 parts of Lactose / Whey Protein / Lactic Acid / Water, 0.5-1 parts of Water / Pleurotus eryngii Extract / p-hydroxyacetophenone / 1,2-hexanediol, and 0.05-0.3 parts of Water / Phyllostachys edulis Extract / p-hydroxyacetophenone / 1,2-hexanediol.

[0007] Secondly, the present invention provides the use of a composition having long-lasting anti-wrinkle, skin elasticity-improving and firming effects in the preparation of skin care products.

[0008] Preferably, the skin care product includes any one of cream, lotion, serum, or water.

[0009] Thirdly, the present invention provides an eye cream comprising the following components in parts by weight: 4-12 parts of the aforementioned composition having long-lasting anti-wrinkle, skin elasticity-improving and firming effects, 8-25 parts of moisturizer, 7-16 parts of emollient, 2-5 parts of emulsifier, 0.4-1.2 parts of thickener, 0.05-0.3 parts of chelating agent, and solvent to make up to 100 parts.

[0010] Preferably, the moisturizer includes at least one of glycerin, butylene glycol, 1,2-pentanediol, betaine, glyceryl glucoside / glycerin, 1,2-hexanediol, water / butylene glycol / tremella polysaccharide, sodium hyaluronate, and caprylyl glycol.

[0011] Preferably, the emollient comprises at least one of polydimethylsiloxane, cetyl ethylhexanoate, isotretinoate isononanoate, polydimethylsiloxane / polydimethylsiloxane and vinyl polydimethylsiloxane crosspolymers, C10-18 fatty acid triglycerides, caprylic / capric triglycerides, pentaerythritol tetra(ethylhexanoate), behenol, and mulberry fruit oil.

[0012] Preferably, the emulsifier comprises at least one of polyglycerol-6 distearate / jojoba ester / polyglycerol-3 beeswax ester / cetyl alcohol, sodium polyacrylate / hydrogenated polydecene / PPG-5-laurate polyether-5, and sodium stearoyl glutamate.

[0013] Preferably, the thickener comprises at least one of hydroxyethyl acrylate and sodium acryloyl dimethyl taurate copolymer / polysorbate-60 / sorbitan isostearate and xanthan gum.

[0014] Preferably, the chelating agent includes at least one of sodium citrate and disodium EDTA.

[0015] Preferably, the solvent is water.

[0016] Preferably, the eye cream further includes at least one of emulsifiers, antioxidants, skin conditioning agents, and fragrances.

[0017] Preferably, the co-emulsifier comprises cetearyl alcohol.

[0018] Preferably, the antioxidant comprises tocopherol / sunflower seed oil.

[0019] Preferably, the skin conditioning agent comprises dipotassium glycyrrhizate.

[0020] Preferably, the fragrance includes bergamot fruit oil / cedarwood oil.

[0021] Preferably, the raw material components include the following parts by weight: 2-6 parts of Bifida ferment lysate / phenoxyethanol / sodium benzoate, 1-3 parts of butylene glycol / hydroxypropyltetrahydropyranotriol / water, 0.5-1 parts of lactose / whey protein / lactic acid / water, 0.5-1 parts of water / Agaricus blazei extract / p-hydroxyacetophenone / 1,2-hexanediol, 0.05-0.3 parts of water / Agaricus palmatus extract / p-hydroxyacetophenone / 1,2-hexanediol, 3-7 parts of glycerin, 2-5 parts of butylene glycol, 1-3 parts of 1,2-pentanediol, 0.3-0.8 parts of betaine, 0.4-1 part of glyceryl glucoside / glycerin, 0.2-0.5 parts of 1,2-hexanediol, 0.1-0.3 parts of water / butylene glycol / Tremella fuciformis polysaccharide, and sodium hyaluronate. 0.04-0.07 parts, 0.03-0.08 parts, polydimethylsiloxane 2-4 parts, cetyl ethylhexanoate 1-3 parts, isotretinoate isonononate 1-3 parts, polydimethylsiloxane / polydimethylsiloxane and vinyl polydimethylsiloxane crosspolymer 1-1.5 parts, C10-18 fatty acid triglycerides 0.8-1 parts, caprylic / capric triglycerides 0.8-1 parts, pentaerythritol tetra(ethylhexanoate) ester 0.6-0.8 parts, behenol 0.3-0.5 parts, morrhagic palm fruit oil 0.1-0.2 parts, polyglycerol-6 distearate / jojoba ester / polyglycerol-3 beeswax ester / cetyl alcohol 2-3 parts, sodium polyacrylate / hydrogenated polydecene / PPG-5-laurate polyether-5 0.4-0.6 parts, sodium stearoyl glutamate 0.3-0.5 parts, hydroxyethyl acrylate and sodium acryloyl dimethyl taurate copolymer / polysorbate-60 / sorbitan isostearate 0.5-1 parts, xanthan gum 0.02-0.08 parts, sodium citrate 0.05-0.2 parts, disodium EDTA 0.02-0.05 parts, cetearyl alcohol 1-2 parts, tocopherol / sunflower seed oil 0.1-0.2 parts, dipotassium glycyrrhizate 0.03-0.06 parts, castor oil / North African cedar bark oil 0.05-0.08 parts, solvent to bring to 100 parts.

[0022] Fourthly, the present invention also provides a method for preparing the aforementioned eye cream, comprising the following steps:

[0023] The moisturizer, emollient, emulsifier, thickener, chelating agent, and a composition with long-lasting anti-wrinkle, skin elasticity-improving, and firming effects are weighed in proportion, added to a solvent, and stirred evenly to obtain the eye cream.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] This invention utilizes a composition made from Bifida ferment lysate, hydroxypropyl tetrahydropyranotriol, lactose, whey protein, lactic acid, *Agaricus blazei* extract, and *Phyllostachys edulis* extract as active ingredients. The resulting eye cream exhibits remarkably long-lasting anti-wrinkle, skin elasticity-improving, and firming effects. After 28 days of use, the skin elasticity R2 value at the corners of the eyes increased by over 20%, the total skin stretch displacement R0 value decreased by over 40%, the wrinkle area decreased by over 15%, and the wrinkle depth decreased by over 27%. Furthermore, the effects after 28 days of use are significantly better than those after 14 days of use. Attached Figure Description

[0026] Other features, objects, and advantages of the present invention will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings:

[0027] Figure 1 Photographs of eye wrinkles are shown for three typical subjects who used the eye cream prepared in Example 1. Detailed Implementation

[0028] The present invention will now be described in detail with reference to specific embodiments. These embodiments will help those skilled in the art to further understand the present invention, but do not limit the invention in any way. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention. These all fall within the scope of protection of the present invention.

[0029] The terms "preferred," "more preferably," and "more suitable" used in this invention refer to embodiments of the invention that provide certain beneficial effects under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the description of one or more preferred embodiments does not imply that other embodiments are unavailable, nor is it intended to exclude other embodiments from the scope of this invention.

[0030] It should be understood that, except in any operational instance or otherwise indicated, all figures representing the amounts of ingredients used, for example, in the specification and claims, should be understood to be modified in all cases by the term "about". Therefore, unless otherwise stated, the numerical parameters set forth in the following specification and appended claims are approximations varying with the desired performance to be obtained according to the invention. It is not at all an attempt to limit the application of the doctrine of equivalents to the scope of the claims; each numerical parameter should be interpreted at least according to the number of significant figures reported and by applying ordinary rounding techniques.

[0031] Although the numerical ranges and parameters illustrating the broad scope of the invention are approximate, the values ​​listed in the specific examples are reported as precisely as possible. However, any numerical value inherently contains some error that is necessarily caused by the standard deviation found in their respective test measurements.

[0032] The following embodiments provide a composition with long-lasting anti-wrinkle, skin elasticity-improving, and firming effects, comprising the following raw material components in parts by weight: 2-6 parts of Bifida Ferment Lysate / Phenoxyethanol / Sodium Benzoate, 1-3 parts of Butylene Glycol / Hydroxypropyl Tetrahydropyranotriol / Water, 0.5-1 parts of Lactose / Whey Protein / Lactic Acid / Water, 0.5-1 parts of Water / Agaricus Tropii Extract / p-hydroxyacetophenone / 1,2-Hexanediol, and 0.05-0.3 parts of Water / Agaricus Palmatus Extract / p-hydroxyacetophenone / 1,2-Hexanediol. The active ingredients of this composition are Bifida Ferment Lysate, Hydroxypropyl Tetrahydropyranotriol, Lactose, Whey Protein, Lactic Acid, Agaricus Tropii Extract, and Agaricus Palmatus Extract.

[0033] In one specific embodiment, the bifida ferment lysate / phenoxyethanol / sodium benzoate is derived from the commercial Repair Complex CLR. TM PF is composed of: Bifida ferment lysate, phenoxyethanol, and sodium benzoate.

[0034] In one specific embodiment, the lactose / whey protein / lactic acid / water is derived from commercial MPC. TM –MilkPeptide Complex, its components are: lactose, whey protein, lactic acid, and water.

[0035] In one specific embodiment, the butanediol / hydroxypropyltetrahydropyranotriol / water is derived from commercial products. S-30 (manufactured by Shanghai Keqin Technology Co., Ltd.) consists of: butanediol, hydroxypropyltetrahydropyranotriol, and water.

[0036] In one specific embodiment, the water / Pleurotus eryngii extract / p-hydroxyacetophenone / 1,2-hexanediol is derived from commercial Pleurotus eryngii extract, and its components are: water, Pleurotus eryngii extract, p-hydroxyacetophenone, and 1,2-hexanediol.

[0037] In one specific embodiment, the water / palmleaf extract / p-hydroxyacetophenone / 1,2-hexanediol is derived from commercial palmleaf leaf extract (manufactured by Shanghai Jiaxin Biotechnology Co., Ltd.), and its components are: water, palmleaf extract, p-hydroxyacetophenone, and 1,2-hexanediol.

[0038] The following embodiments also provide an eye cream comprising the following raw material components in parts by weight: 2-6 parts of Bifida Ferment Lysate / Phenoxyethanol / Sodium Benzoate, 1-3 parts of Butylene Glycol / Hydroxypropyl Tetrahydropyranotriol / Water, 0.5-1 part of Lactose / Whey Protein / Lactic Acid / Water, 0.5-1 part of Water / Agaricus Tropii Extract / p-hydroxyacetophenone / 1,2-Hexanediol, 0.05-0.3 parts of Water / Agaricus Palmatus Extract / p-hydroxyacetophenone / 1,2-Hexanediol, 3-7 parts of Glycerin (Moisturizer), 2-5 parts of Butylene Glycol (Moisturizer), 1-3 parts of 1,2-Pentanediol (Moisturizer), and 1 part of Betaine (Moisturizer). 0.3-0.8 parts, 0.4-1 part of glyceryl glucoside / glycerin (moisturizer), 0.2-0.5 parts of 1,2-hexanediol (moisturizer), 0.1-0.3 parts of water / butylene glycol / tremella polysaccharide (moisturizer), 0.04-0.07 parts of sodium hyaluronate (moisturizer), 0.03-0.08 parts of caprylyl glycol (moisturizer), 2-4 parts of polydimethylsiloxane (emollient), 1-3 parts of cetyl ethylhexanoate (emollient), 1-3 parts of isotretinoinate (emollient), and 1-1.5 parts of polydimethylsiloxane / polydimethylsiloxane and vinyl polydimethylsiloxane crosspolymer (emollient). 0.8-1 part of C10-18 fatty acid triglycerides (emollient), 0.8-1 part of caprylic / capric triglycerides (emollient), 0.6-0.8 part of pentaerythritol tetra(ethylhexanoate) ester (emollient), 0.3-0.5 part of behenol (emollient), 0.1-0.2 part of morrhagic palm fruit oil (emollient), 2-3 parts of polyglycerol-6 distearate / jojoba ester / polyglycerol-3 beeswax ester / cetyl alcohol (emulsifier), 0.4-0.6 parts of sodium polyacrylate / hydrogenated polydecene / PPG-5-lauryl ether-5 (emulsifier), and 0.3-0.5 parts of sodium stearoyl glutamate (emulsifier). Hydroxyethyl acrylate and sodium acryloyl dimethyl taurate copolymer / polysorbate-60 / sorbitan isostearate (thickener) 0.5-1 parts, xanthan gum (thickener) 0.02-0.08 parts, sodium citrate (chelating agent) 0.05-0.2 parts, disodium EDTA (chelating agent) 0.02-0.05 parts, cetearyl alcohol (co-emulsifier) ​​1-2 parts, tocopherol / sunflower seed oil (antioxidant) 0.1-0.2 parts, dipotassium glycyrrhizate (skin conditioning agent) 0.03-0.06 parts, castor oil / North African cedar bark oil (fragrance agent) 0.05-0.08 parts, solvent to bring to 100 parts.

[0039] In the following examples, all the raw materials used, such as moisturizers, emulsifiers, co-emulsifiers, thickeners, chelating agents, antioxidants, skin conditioning agents, and fragrances, are commercially available.

[0040] Example 1

[0041] This embodiment provides an eye cream comprising the following components: a composition with long-lasting anti-wrinkle and firming effects, a moisturizer, a skin-nourishing agent, an emulsifier, a co-emulsifier, a thickener, a chelating agent, an antioxidant, a skin conditioning agent, a fragrance, and a solvent; wherein the composition with long-lasting anti-wrinkle and firming effects includes the following active ingredients: Bifida ferment lysate, hydroxypropyl tetrahydropyranotriol, lactose, whey protein, lactic acid, *Agaricus blazei* extract, and *Phyllostachys edulis* extract. The specific composition and weight ratio of the raw materials (total weight parts: 100 parts) are shown in Table 1. The specific preparation steps of the eye cream are as follows:

[0042] 1) Place appropriate amounts of water, glycerol, butylene glycol, hydroxyethyl acrylate and sodium acryloyl dimethyl taurate copolymer / polysorbate-60 / sorbitan isostearate, betaine, glyceryl glucoside / glycerol, sodium stearoyl glutamate, sodium hyaluronate, xanthan gum and disodium EDTA into a mixing pot, stir and heat to 80℃, homogenize at 1500 rpm for 1 min, then stir for 15 min until dissolved and homogeneous to obtain phase A;

[0043] 2) Add polyglycerol-6 distearate / jojoba ester / polyglycerol-3 beeswax ester / cetyl alcohol, polydimethylsiloxane, cetyl ethylhexanoate, isotretinoate isononanoate, cetearyl alcohol, polydimethylsiloxane / polydimethylsiloxane and vinyl polydimethylsiloxane crosspolymer, C10-18 fatty acid triglycerides, caprylic / capric triglycerides, pentaerythritol tetra(ethylhexanoate), behenol, tocopherol / helianthus annuus seed oil to the oil phase pot, heat to 85°C, stir and dissolve evenly to obtain phase B;

[0044] 3) Keep the temperature of the mixing pot after step 1) at 80℃, put the B phase material that was mixed evenly in step 2 into the mixing pot, homogenize at 2500rpm for 3min, and stir for 15min to dissolve evenly.

[0045] 4) Cool down to 65℃, add sodium polyacrylate / hydrogenated polydecene / PPG-5-lauryl alcohol polyether-5 to a mixing pot, homogenize at 2500rpm for 3min, and stir for 10min to dissolve evenly.

[0046] 5) Add lactose / whey protein / lactic acid / water, sodium citrate, and dipotassium glycyrrhizate to an appropriate amount of water and mix well to obtain phase C;

[0047] 6) Cool to 40℃, add the C phase material and 1,2-pentanediol, Bifida ferment lysate / phenoxyethanol / sodium benzoate, butylene glycol / hydroxypropyltetrahydropyranotriol / water, 1,2-hexanediol, water / butylene glycol / Tremella fuciformis polysaccharide, Mauritia flaxusa fruit oil, Citrus aurantium bergama fruit oil / Cedrus deodara wood oil, caprylyl glycol, water / Agaricus lazei extract / p-hydroxyacetophenone / 1,2-hexanediol, water / Palmaria palmata extract / p-hydroxyacetophenone / 1,2-hexanediol to a mixing pot, stir for 20 minutes to dissolve evenly;

[0048] 7) Cool down to 38℃, vacuum, filter and remove from the pot to obtain eye cream.

[0049] Example 2

[0050] This embodiment provides an eye cream comprising the following components: a composition with long-lasting anti-wrinkle and firming effects, a moisturizer, a skin-nourishing agent, an emulsifier, a co-emulsifier, a thickener, a chelating agent, an antioxidant, a skin conditioning agent, a fragrance, and a solvent; wherein the composition with long-lasting anti-wrinkle and firming effects includes the following active ingredients: Bifida ferment lysate, hydroxypropyl tetrahydropyranotriol, lactose, whey protein, lactic acid, *Agaricus blazei* extract, and *Phyllostachys edulis* extract. The specific composition and weight ratio of the raw materials (total weight parts: 100 parts) are shown in Table 1. The preparation steps of the eye cream are the same as in Example 1.

[0051] Example 3

[0052] This embodiment provides an eye cream comprising the following components: a composition with long-lasting anti-wrinkle and firming effects, a moisturizer, a skin-nourishing agent, an emulsifier, a co-emulsifier, a thickener, a chelating agent, an antioxidant, a skin conditioning agent, a fragrance, and a solvent; wherein the composition with long-lasting anti-wrinkle and firming effects includes the following active ingredients: Bifida ferment lysate, hydroxypropyl tetrahydropyranotriol, lactose, whey protein, lactic acid, *Agaricus blazei* extract, and *Phyllostachys edulis* extract. The specific composition and weight ratio of the raw materials (total weight parts: 100 parts) are shown in Table 1. The preparation steps of the eye cream are the same as in Example 1.

[0053] Table 1

[0054]

[0055]

[0056] Comparative Example 1

[0057] This comparative example provides an eye cream whose ingredient composition and weight ratio are shown in Table 2. Compared with Example 1, it only omits the addition of water / palmaria palmata extract / p-hydroxyacetophenone / 1,2-hexanediol. The preparation steps of the eye cream are the same as those in Example 1.

[0058] Comparative Example 2

[0059] This comparative example provides an eye cream whose ingredient composition and weight ratio are shown in Table 2. Compared with Example 1, it only omits the addition of water / Agaricus blazei extract / p-hydroxyacetophenone / 1,2-hexanediol. The preparation steps of the eye cream are the same as those in Example 1.

[0060] Comparative Example 3

[0061] This comparative example provides an eye cream whose ingredient composition and weight proportions are shown in Table 2. Compared with Example 1, it only omits the addition of water / Palmaria palmata extract / p-hydroxyacetophenone / 1,2-hexanediol, and the weight proportion of water / Agaricus lazei extract / p-hydroxyacetophenone / 1,2-hexanediol is 0.7 parts. The preparation steps of the eye cream are the same as those in Example 1.

[0062] Comparative Example 4

[0063] This comparative example provides an eye cream whose ingredient composition and weight ratio are shown in Table 2. Compared with Example 3, only 0.5 parts by weight of water / palmaria palmata extract / p-hydroxyacetophenone / 1,2-hexanediol were added. The preparation steps of the eye cream are the same as those in Example 3.

[0064] Comparative Example 5

[0065] This comparative example provides an eye cream whose ingredient composition and weight ratio are shown in Table 2. Compared with Example 3, only 1.2 parts by weight of water / Agaricus blazei extract / p-hydroxyacetophenone / 1,2-hexanediol were added. The preparation steps of the eye cream are the same as those in Example 3.

[0066] Comparative Example 6

[0067] This comparative example provides an eye cream whose ingredient composition and weight proportions are shown in Table 2. Compared with Example 1, only 0.3 parts by weight of lactose / whey protein / lactic acid / water are added. The preparation steps of the eye cream are the same as those in Example 1.

[0068] Table 2

[0069]

[0070]

[0071] Efficacy verification:

[0072] The eye creams prepared in Examples 1-3 and Comparative Examples 1-6 were used as test products for anti-wrinkle and firming efficacy testing. The experimental data of each group are the average values ​​of multiple test subjects (n≥10).

[0073] 1) Test subjects

[0074] The study included healthy subjects aged 30-50 years who were identified as having sensitive skin (stinging score ≥3 points) by the lactic acid tingling test and had fine lines or wrinkles on the test site.

[0075] 2) How to use

[0076] After cleansing, take an appropriate amount of the test product and gently massage it evenly onto the eye area until absorbed. Use twice daily, once in the morning and once in the evening. During the testing period, the test subjects should not change any other lifestyle, dietary, or skincare habits, and should use the provided test product entirely instead of their own eye cream.

[0077] 3) Testing methods

[0078] Skin elasticity R² values ​​(the closer the R² value is to 100%) were measured before use (baseline values), after 2 weeks of use, and after 4 weeks of use on each test subject. The total skin stretch displacement RO value (RO reflects the maximum stretch displacement of the skin under negative pressure; the smaller the value, the tighter the skin) was also measured using the MPA580 skin elasticity tester (Cutometer probe). The proportion of crow's feet area was detected using VISIA-CR and IPP image analysis of facial photographs, and the proportion and depth of wrinkles were detected using a PRIMOS CR skin 3D imaging system. All test sites were the corners of the eyes.

[0079] All measurements were conducted in a temperature and humidity controlled room, with a temperature of 20-22℃ and a relative humidity of 40-60%.

[0080] 4) Test Results

[0081] 4.1 The skin elasticity R2 value and total skin tensile displacement R0 value were measured using the eye creams prepared in Examples 1-3 and Comparative Examples 1-6 as test samples. The R2 value improvement rate after use was calculated based on the R2 value before use (D0) and after use (D14, D28) (R2 value improvement rate = (R2 value after use - R2 value before use) / R2 value before use * 100%). The R0 value decrease rate after use was calculated based on the R0 value before use (D0) and after use (D14, D28) (R0 value decrease rate = (R0 value before use - R0 value after use) / R0 value before use * 100%). The results are shown in Table 1.

[0082] Table 1

[0083]

[0084] As can be seen from the results in Table 1, the eye creams prepared in Examples 1-3 have a very good effect on improving skin elasticity and firmness. Compared with before use (D0), the R2 value increased by more than 10% and the R0 value decreased by more than 25% after 2 weeks of use. After 4 weeks of use, the R2 value increased by more than 20% and the R0 value decreased by more than 40%, indicating that the effect of long-term use is more obvious.

[0085] Further comparison of the results of Example 1 and Comparative Examples 1-3 shows that, without the addition of water / palmaria apalmata extract / p-hydroxyacetophenone / 1,2-hexanediol or water / agaricus pufferfish extract / p-hydroxyacetophenone / 1,2-hexanediol, and even when the total weight percentages of these two raw material components remain unchanged, the rate of increase in R2 value is significantly lower than that of Example 1, and the rate of decrease in R0 value is significantly lower than that of Example 1.

[0086] Further comparison of the results of Example 3 with those of Comparative Examples 4-5 shows that when the added water / palmaria apalmata extract / p-hydroxyacetophenone / 1,2-hexanediol or water / agaricus pufferfish extract / p-hydroxyacetophenone / 1,2-hexanediol content is too high, the increase rate of R2 value and the decrease rate of R0 value are both lower than those of Example 3.

[0087] Further comparison of the results of Example 1 and Comparative Example 6 shows that when the added lactose / whey protein / lactic acid / water content is too low, the increase rate of R2 value and the decrease rate of R0 value are significantly lower than those of Example 1.

[0088] 4.2 The wrinkle area ratio and wrinkle depth results were measured using the eye creams prepared in Examples 1-3 and Comparative Examples 1-5 as test samples. The wrinkle area ratio reduction rate after use was calculated based on the wrinkle area ratio before use (D0) and after use (D14, D28) (wrinkle area ratio reduction rate = (wrinkle area ratio before use - wrinkle area ratio after use) * 100%). The wrinkle depth reduction rate after use was calculated based on the wrinkle depth before use (D0) and after use (D14, D28) (wrinkle depth reduction rate = (wrinkle depth before use - wrinkle depth after use) / wrinkle depth before use * 100%). The results are shown in Table 2.

[0089] Table 2

[0090]

[0091] As can be seen from the results in Table 1, the eye creams prepared in Examples 1-3 have very good anti-wrinkle effects. Compared with before use (D0), the wrinkle area ratio decreased by more than 10% and the wrinkle depth decreased by more than 14% after 2 weeks of use. After 4 weeks of use, the wrinkle area ratio decreased by more than 16% and the wrinkle depth decreased by more than 27%, indicating that the long-term effect is more obvious.

[0092] Further comparison of the results of Example 1 with those of Comparative Examples 1-3 shows that, without the addition of water / palmaria apalmata extract / p-hydroxyacetophenone / 1,2-hexanediol or water / agaricus blazei extract / p-hydroxyacetophenone / 1,2-hexanediol, and even when the total weight percentage of these two raw material components remains unchanged, the rate of decrease in wrinkle area and the rate of decrease in wrinkle depth are significantly lower than those in Example 1.

[0093] Further comparison of the results of Example 3 with those of Comparative Examples 4-5 shows that when the added water / palmaria apalmata extract / p-hydroxyacetophenone / 1,2-hexanediol or water / agaricus labrazei extract / p-hydroxyacetophenone / 1,2-hexanediol content is too high, the rate of decrease in wrinkle area ratio and the rate of decrease in wrinkle depth are significantly lower than those in Example 1.

[0094] Example 1 was used as the test sample. Photos of crow's feet in subjects (Examples 1-3) before use (D0), after 2 weeks (D14), and after 4 weeks (28D) are shown below. Figure 1 As shown, by Figure 1 The changes in wrinkles are clearly visible.

[0095] Furthermore, after using each test sample, all subjects reported no itching, stinging, burning, redness, or edema during use, indicating that the eye cream prepared in this invention is suitable for sensitive skin.

[0096] This invention has many specific applications, and the above description is only a preferred embodiment. It should be noted that the above embodiments are for illustrative purposes only and are not intended to limit the scope of protection of this invention. For those skilled in the art, several improvements can be made without departing from the principle of this invention, and these improvements should also be considered within the scope of protection of this invention.

Claims

1. A composition having long-lasting anti-wrinkle, skin elasticity-improving, and firming effects, characterized in that, It is composed of the following raw material components in parts by weight: Bifida ferment lysate / phenoxyethanol / sodium benzoate 2-6 parts, butylene glycol / hydroxypropyltetrahydropyranotriol / water 1-3 parts, lactose / whey protein / lactic acid / water 0.5-1 parts, water / Agaricus blazei extract / p-hydroxyacetophenone / 1,2-hexanediol 0.5-1 parts, water / Agaricus palmatus extract / p-hydroxyacetophenone / 1,2-hexanediol 0.05-0.3 parts; The trade name of the Bifida Ferment Lysate / Phenoxyethanol / Sodium Benzoate is Repair ComplexCLR™ PF; The product name of the butanediol / hydroxypropyltetrahydropyranotriol / water is Anallerg®--Proyouth® S-30; The trade name for the lactose / whey protein / lactic acid / water is MPC™ – Milk Peptide Complex; The commercial name of the water / Platycladus orientalis extract / p-hydroxyacetophenone / 1,2-hexanediol is Platycladus orientalis extract. The product described in the article, which is a water / palmleaf extract / p-hydroxyacetophenone / 1,2-hexanediol, is marketed as palmleaf leaf extract and is manufactured by Shanghai Jiaxin Biotechnology Co., Ltd.

2. Use of the composition according to claim 1, which has long-lasting anti-wrinkle, skin elasticity-improving and firming effects, in the preparation of skin care products.

3. An eye cream, characterized in that, The components include the following parts by weight: The composition of claim 1, which has long-lasting anti-wrinkle, skin elasticity-improving and firming effects, comprises 4-12 parts of moisturizer, 8-25 parts of emollient, 7-16 parts of skin moisturizer, 2-5 parts of emulsifier, 0.4-1.2 parts of thickener, 0.05-0.3 parts of chelating agent, and solvent to make up to 100 parts.

4. The eye cream according to claim 3, characterized in that, The moisturizer includes at least one of glycerin, butylene glycol, 1,2-pentanediol, betaine, glyceryl glucoside / glycerin, 1,2-hexanediol, water / butylene glycol / tremella polysaccharide, sodium hyaluronate, and caprylyl glycol.

5. The eye cream according to claim 3, characterized in that, The emollient includes at least one of the following: dimethicone, cetyl ethylhexanoate, isotretinoate, dimethicone / dimethicone and vinyl dimethicone crosspolymers, C10-18 fatty acid triglycerides, caprylic / capric triglycerides, pentaerythritol tetra(ethylhexanoate), behenol, and morrhagic acid fruit oil.

6. The eye cream according to claim 3, characterized in that, The emulsifier includes at least one of polyglycerol-6 distearate / jojoba ester / polyglycerol-3 beeswax ester / cetyl alcohol, sodium polyacrylate / hydrogenated polydecene / PPG-5-lauryl ether-5, and sodium stearoyl glutamate; The thickener includes at least one of hydroxyethyl acrylate and sodium acryloyl dimethyl taurate copolymer / polysorbate-60 / sorbitan isostearate and xanthan gum; The chelating agent includes at least one of sodium citrate and disodium EDTA. The solvent is water.

7. The eye cream according to claim 3, characterized in that, The eye cream also includes at least one of the following: emulsifier, antioxidant, skin conditioning agent, and fragrance. The co-emulsifier includes cetearyl alcohol; The antioxidants include tocopherol / sunflower seed oil; The skin conditioning agent includes dipotassium glycyrrhizate; The fragrance includes bergamot fruit oil / cedarwood oil.

8. The eye cream according to claim 3, characterized in that, The raw material components include the following parts by weight: Bifida ferment lysate / phenoxyethanol / sodium benzoate 2-6 parts, butylene glycol / hydroxypropyltetrahydropyranotriol / water 1-3 parts, lactose / whey protein / lactic acid / water 0.5-1 part, water / Agaricus blazei extract / p-hydroxyacetophenone / 1,2-hexanediol 0.5-1 part, water / Agaricus palmatus extract / p-hydroxyacetophenone / 1,2-hexanediol 0.05-0.3 parts, glycerin 3-7 parts, butylene glycol 2-5 parts, 1,2-pentanediol 1-3 parts. Betaine 0.3-0.8 parts, glyceryl glucoside / glycerol 0.4-1 parts, 1,2-hexanediol 0.2-0.5 parts, water / butanediol / tremella polysaccharide 0.1-0.3 parts, sodium hyaluronate 0.04-0.07 parts, caprylyl glycol 0.03-0.08 parts, polydimethylsiloxane 2-4 parts, cetyl ethylhexanoate 1-3 parts, isotretinoate isonononate 1-3 parts, polydimethylsiloxane / polydimethylsiloxane and vinyl polydimethylsiloxane crosspolymer 1-1.5 parts, C10-18 0.8-1 part of fatty acid triglycerides, 0.8-1 part of caprylic / capric triglycerides, 0.6-0.8 part of pentaerythritol tetra(ethylhexanoate), 0.3-0.5 part of behenol, 0.1-0.2 part of mulberry fruit oil, 2-3 parts of polyglycerol-6 distearate / jojoba esters / polyglycerol-3 beeswax ester / cetyl alcohol, sodium polyacrylate / hydrogenated polydecene / PPG-5-laurate polyether-5 0.4-0.6 parts, sodium stearoyl glutamate 0.3-0.5 parts, hydroxyethyl acrylate and sodium acryloyl dimethyl taurate copolymer / polysorbate-60 / sorbitan isostearate 0.5-1 parts, xanthan gum 0.02-0.08 parts, sodium citrate 0.05-0.2 parts, disodium EDTA 0.02-0.05 parts, cetearyl alcohol 1-2 parts, tocopherol / sunflower seed oil 0.1-0.2 parts, dipotassium glycyrrhizate 0.03-0.06 parts, castor oil / North African cedar bark oil 0.05-0.08 parts, solvent to bring to 100 parts.

9. A method for preparing an eye cream according to any one of claims 3-8, characterized in that, Includes the following steps: The moisturizer, emollient, emulsifier, thickener, chelating agent, and a composition with long-lasting anti-wrinkle, skin elasticity-improving, and firming effects are weighed in proportion, added to a solvent, and stirred evenly to obtain the eye cream.

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