A traditional Chinese medicine composition for clearing lung and relieving asthma, granular medicine and application thereof

Abstract

This invention provides a traditional Chinese medicine composition for clearing the lungs and relieving asthma, its granules, and their applications, relating to the field of traditional Chinese medicine technology. The traditional Chinese medicine composition for clearing the lungs and relieving asthma of this invention is prepared from the following raw materials in the indicated weight proportions: Ephedra 8-12g, Earthworm 8-12g, Bitter Apricot Kernel 8-12g, Mulberry Bark 8-12g, Coltsfoot Flower 13-18g, Stemona 13-18g, Platycodon Root 8-12g, Prepared Pinellia Rhizome 8-12g, Tangerine Peel 8-12g, Ginkgo Root 8-12g, Scutellaria Root 13-18g, Perilla Seed 13-18g, Trichosanthes Peel 25-35g, Peucedanum Root 8-12g, and Belamcanda Rhizome 8-12g. The traditional Chinese medicine formula provided by this invention has good clinical efficacy in treating chronic obstructive pulmonary disease, with high clinical control and efficacy rates, and a high overall effective rate.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition for clearing the lungs and relieving asthma, its granule form, and its application. Background Technology

[0002] Chronic obstructive pulmonary disease (COPD) is one of the most common chronic respiratory diseases and has become a global public health concern. COPD has a high incidence and mortality rate; if poorly controlled, it can lead to acute exacerbations or complications, including respiratory failure, pulmonary encephalopathy, and cardiovascular events. This significantly reduces patients' quality of life and life expectancy, while also increasing psychological stress and placing a heavy economic burden on society. Therefore, given the serious situation of COPD incidence, its prevention, treatment, and onset have attracted considerable attention from the medical community. With the development of modern medicine, clinical treatment of COPD primarily relies on Western medicine, typically using bronchodilators, corticosteroids, and antibiotics. However, the drawbacks of these drugs, such as dependence and significant side effects, are difficult to overcome, resulting in generally low patient acceptance and adherence, thus affecting treatment effectiveness. Traditional Chinese medicine (TCM) has a long history of researching and treating this disease. Numerous clinical studies both domestically and internationally have reported reliable efficacy of TCM in treating AECOPD (acute exacerbations of chronic obstructive pulmonary disease). In recent years, TCM has achieved significant results in improving inflammatory responses, inhibiting airway remodeling, regulating oxidative and antioxidant balance, and preventing complications in AECOPD. Furthermore, TCM has a broad range of targets, few side effects, is simple to administer, inexpensive, and generally well-tolerated by patients, avoiding the limitations of Western medicine. It provides new insights into treatment and has significant research and clinical application value. However, currently, the level of TCM efficacy reaching significant or higher in treating chronic obstructive pulmonary disease is low, which is insufficient to meet the needs of patients. Summary of the Invention

[0003] In view of this, the present invention proposes a traditional Chinese medicine composition for clearing the lungs and relieving asthma, as well as its granule form and application, which effectively improves the efficacy of traditional Chinese medicine in treating chronic obstructive pulmonary disease.

[0004] The technical solution of this invention is implemented as follows:

[0005] A traditional Chinese medicine composition for clearing the lungs and relieving asthma is prepared from the following raw materials in the indicated weight proportions: Ephedra 8-12g, Earthworm 8-12g, Bitter Almond 8-12g, Mulberry Bark 8-12g, Coltsfoot Flower 13-18g, Stemona 13-18g, Platycodon 8-12g, Prepared Pinellia 8-12g, Citrus Reticulata Peel 8-12g, Ginkgo 8-12g, Scutellaria 13-18g, Perilla Seed 13-18g, Trichosanthes Peel 25-35g, Peucedanum praeruptorum 8-12g, and Belamcanda chinensis 8-12g.

[0006] Furthermore, the aforementioned lung-clearing and asthma-relieving traditional Chinese medicine composition is prepared from the following raw materials in the indicated weight proportions: Ephedra 9-11g, Earthworm 9-11g, Bitter Almond 9-11g, Mulberry Bark 9-11g, Coltsfoot Flower 14-16g, Stemona 14-16g, Platycodon 9-11g, Prepared Pinellia 9-11g, Citrus Reticulata Peel 9-11g, Ginkgo 9-11g, Scutellaria 14-16g, Perilla Seed 14-16g, Trichosanthes Peel 28-32g, Peucedanum praeruptorum 9-11g, and Belamcanda chinensis 9-11g.

[0007] Furthermore, the traditional Chinese medicine composition also contains licorice.

[0008] Furthermore, the traditional Chinese medicine composition also contains licorice, bupleurum, and poria.

[0009] Furthermore, the traditional Chinese medicine composition is prepared from the following raw materials in the indicated weight proportions: Ephedra 8-12g, Earthworm 8-12g, Bitter Almond 8-12g, Mulberry Bark 8-12g, Coltsfoot Flower 13-18g, Stemona 13-18g, Platycodon 8-12g, Prepared Pinellia 8-12g, Citrus Reticulata Peel 8-12g, Ginkgo 8-12g, Perilla Seed 13-18g, Trichosanthes Peel 25-35g, Bupleurum 13-18g, Peucedanum praeruptorum 8-12g, Belamcanda chinensis 8-12g, Licorice 8-12g, Scutellaria baicalensis 13-18g, Poria cocos 13-18g.

[0010] Furthermore, the traditional Chinese medicine composition is prepared from the following raw materials in the indicated weight proportions: Ephedra 9-11g, Earthworm 9-11g, Bitter Almond 9-11g, Mulberry Bark 9-11g, Coltsfoot Flower 14-16g, Stemona 14-16g, Platycodon 9-11g, Prepared Pinellia 9-11g, Citrus Reticulata Peel 9-11g, Ginkgo 9-11g, Perilla Seed 14-16g, Trichosanthes Peel 28-32g, Bupleurum 14-16g, Peucedanum praeruptorum 9-11g, Belamcanda chinensis 9-11g, Licorice 9-11g, Scutellaria baicalensis 14-16g, Poria cocos 14-16g.

[0011] Furthermore, the traditional Chinese medicine composition is prepared from the following raw materials in the indicated weight proportions: Ephedra 10g, Earthworm 10g, Bitter Almond 10g, Mulberry Bark 10g, Coltsfoot Flower 15g, Stemona 15g, Platycodon 10g, Prepared Pinellia 10g, Citrus Reticulata Peel 10g, Ginkgo 10g, Perilla Seed 15g, Trichosanthes Peel 30g, Bupleurum 15g, Peucedanum praeruptorum 10g, Belamcanda chinensis 10g, Licorice 10g, Scutellaria baicalensis 15g, Poria cocos 15g.

[0012] Furthermore, the ephedra mentioned is honey-processed ephedra.

[0013] A granular medicine for clearing the lungs and relieving asthma is prepared from the traditional Chinese medicine composition described in this invention.

[0014] The application of any one of the traditional Chinese medicine compositions described in this invention in the preparation of a medicament for treating chronic obstructive pulmonary disease.

[0015] Compared with the prior art, the beneficial effects of the present invention are:

[0016] The traditional Chinese medicine formula provided by this invention has good clinical efficacy in treating chronic obstructive pulmonary disease (COPD) of the phlegm-heat obstructing the lungs type, with high clinical control and efficacy rates, a high overall effective rate, and no adverse reactions. This traditional Chinese medicine formula can also be used to treat acute exacerbations of COPD.

[0017] COPD is not specifically recorded in ancient Chinese medicine texts, and most physicians categorize it under the TCM concept of "lung distension." Patients with lung distension often present with chest fullness, and their symptoms are primarily cough, phlegm, and wheezing. Initially, the disease is located in the lungs, but over time it affects the entire body's organs. The TCM formula provided in this invention works synergistically to clear the lungs, resolve phlegm, stop coughing, and relieve asthma. Ephedra and earthworm are used together as the principal herbs. Ephedra is bitter, pungent, and warm in nature, with an ascending and dispersing property, expelling pathogenic factors, clearing the lungs, stopping coughs, and relieving asthma. Honey-processing enhances its lung-moistening, cough-relieving, and asthma-relieving effects. Earthworm is salty and cold, clearing lung heat, relieving asthma and coughing, and also unblocking the meridians. The combination of these two herbs, clearing and unblocking the meridians, achieves a balance of ascending and descending properties, harmonizing cold and heat, and opening the meridians appropriately. Together, they clear the lung meridians, clear heat, and relieve asthma. Furthermore, earthworm counteracts the side effects of ephedra, such as palpitations or increased blood pressure. The formula uses Scutellaria baicalensis to clear lung heat, Morus alba root bark to purge lung heat, and Bupleurum chinense to soothe lung heat. Together, these three herbs dispel the pathogenic factors causing lung distension and eliminate internal phlegm and heat. Among the adjuvant herbs, Perilla frutescens seed effectively descends rebellious lung qi, eliminates stagnant phlegm, relieves asthma, and benefits the lungs; Pinellia ternata is pungent and warm, drying dampness and resolving phlegm, possessing excellent antitussive effects; Citrus reticulata peel is warm in nature, pungent and bitter in taste, primarily drying dampness and resolving phlegm; Platycodon grandiflorus is bitter, pungent, and neutral, promoting lung function, benefiting the throat, and draining pus; Peucedanum praeruptorum is bitter, pungent, and slightly cold, significantly lowering qi, clearing heat, and eliminating phlegm, making it a key herb for treating phlegm and qi stagnation; Prunus armeniaca seed effectively relieves asthma and also promotes bowel movements and lowers qi; Stemona japonica and Tussilago farfara have synergistic effects in stopping cough and resolving phlegm; Trichosanthes kirilowii peel widens the chest, regulates qi, and resolves phlegm; Ginkgo biloba astringes the lungs and calms asthma; Belamcanda chinensis clears heat and eliminates phlegm. Poria cocos and Glycyrrhiza uralensis tonify qi, harmonize the middle jiao, invigorate the spleen, resolve phlegm, and support the body's resistance to expel pathogens, serving as guiding herbs. The herbs in this formula are mostly pungent and bitter in nature, primarily entering the lung meridian. The pungent flavor disperses and promotes circulation, expelling pathogens from the exterior, regulating qi, promoting blood flow, and aiding in the dissipation of phlegm and dampness. The bitter flavor can both purge and dry; firstly, it can purge because the lung and large intestine are internally and externally related, clearing the bowel qi helps the lung qi descend; secondly, it can descend and purge lung qi, stopping coughs and wheezing caused by upward rebellious lung qi; and thirdly, it can dry dampness, eliminate phlegm and turbidity, and regulate lung qi. The combined use of pungent and bitter herbs has the effect of "pungent opening and bitter descending," ensuring the orderly circulation of lung qi, regulating qi and harmonizing the middle jiao, resolving phlegm and descending rebellious qi, thus achieving the effect of harmonious and smooth flow of qi and blood. This traditional Chinese medicine formula has good clinical efficacy in treating chronic obstructive pulmonary disease. Detailed Implementation

[0018] To better understand the technical content of this invention, specific embodiments are provided below to further illustrate the invention.

[0019] Unless otherwise specified, the experimental methods used in the embodiments of this invention are all conventional methods.

[0020] Unless otherwise specified, all materials and reagents used in the embodiments of this invention are commercially available.

[0021] Example 1

[0022] Traditional Chinese medicine prescription: Honey-processed ephedra 10g, earthworm 10g, bitter almond 10g, mulberry bark 10g, coltsfoot flower 15g, stemona root 15g, platycodon root 10g, prepared pinellia tuber 10g, tangerine peel 10g, ginkgo 10g, scutellaria root 15g, perilla seed 15g, trichosanthes peel 30g, angelica root 10g, belamcanda rhizome 10g, licorice root 10g.

[0023] Example 2

[0024] Traditional Chinese medicine prescription: Honey-processed ephedra 10g, earthworm 10g, bitter almond 10g, mulberry bark 10g, coltsfoot flower 15g, stemona root 15g, platycodon root 10g, prepared pinellia tuber 10g, tangerine peel 10g, ginkgo 10g, scutellaria root 15g, perilla seed 15g, trichosanthes peel 30g, angelica root 10g, belamcanda rhizome 10g, licorice root 10g, bupleurum root 15g, poria cocos 15g.

[0025] Example 3

[0026] Traditional Chinese medicine prescription: Ephedra 8g, Earthworm 12g, Bitter Almond 8g, Mulberry Bark 8g, Coltsfoot Flower 13g, Stemona 18g, Platycodon 8g, Prepared Pinellia 8g, Tangerine Peel 12g, Ginkgo 8g, Scutellaria 15g, Perilla Seed 13g, Trichosanthes 28g, Peucedanum 12g, Belamcanda 8g, Licorice 12g, Bupleurum 18g, Poria 18g.

[0027] Example 4

[0028] Traditional Chinese medicine prescription: Ephedra 12g, Earthworm 8g, Bitter Almond 12g, Mulberry Bark 12g, Coltsfoot Flower 18g, Stemona 13g, Platycodon 12g, Prepared Pinellia 12g, Citrus Reticulata Peel 8g, Ginkgo 12g, Scutellaria 13g, Perilla Seed 13g, Trichosanthes Peel 26g, Peucedanum 8g, Belamcanda 12g, Licorice 8g, Bupleurum 13g, Poria 13g.

[0029] Example 5 - Clinical Application Case

[0030] Mr. Zeng, male, 62 years old, from Haikou, presented on May 19, 2019, with a 7-year history of recurrent cough with sputum and shortness of breath, which had worsened in the past day. Summary of four diagnostic methods: elderly male, alert, fatigued, with a chronic disease appearance, unsteady gait, clear speech, pale yellow complexion, thin build, chest fullness, and slightly shortness of breath. One day prior, after catching a cold, he experienced a worsening of his cough, shortness of breath, and chest tightness, manifesting as copious, thick, yellow sputum, accompanied by shortness of breath, which worsened with activity, chest tightness, weakness in the limbs, poor appetite and sleep, dry stools, dark red tongue with a yellow, greasy coating and teeth marks on the edges, and a thready, slippery pulse. Past medical history: 11 years of chronic bronchitis and 7 years of chronic obstructive pulmonary disease. He regularly takes inhaled Symbicort and oral montelukast. Lifestyle history: nearly 20 years of smoking history, currently smoking occasionally. Physical examination of the lungs revealed a barrel chest, coarse breath sounds in both lungs, dry rales in both lungs, and a few moist rales in both lower lung fields. The electrocardiogram showed no significant abnormalities. Pulmonary function tests showed FEV1 / FVC% <70%, FEV1%pred: 71%. Complete blood count, high-sensitivity C-reactive protein, CRP, liver function, kidney function, and electrolyte panel were all normal.

[0031] Western medicine diagnosis: Acute exacerbation of chronic obstructive pulmonary disease; Traditional Chinese medicine diagnosis: Lung distension, phlegm-heat obstructing the lungs. Treatment principle: Clear lung heat, relieve asthma, resolve phlegm, and stop coughing. Prescription: 10g of honey-processed ephedra, 10g of earthworm, 10g of bitter almond, 10g of mulberry bark, 15g of coltsfoot flower, 15g of stemona root, 10g of platycodon root, 10g of prepared pinellia tuber, 10g of tangerine peel, 10g of ginkgo, 15g of scutellaria root, 15g of perilla seed, 30g of trichosanthes peel, 10g of angelica root, 10g of belamcanda rhizome, 10g of licorice root, 15g of bupleurum root, and 15g of poria cocos. A total of 7 doses, in granule or powder form. Dissolve thoroughly in 100ml-150ml of boiling water until no sediment remains. Take orally, one dose daily, divided into two doses, taken warm after breakfast and dinner. Patients are advised to quit smoking, avoid getting cold, and get adequate rest. Patients are instructed to return for a follow-up visit in half a month.

[0032] Second visit: The patient has quit smoking and reports that chest tightness and shortness of breath have been significantly relieved, the amount of sputum has decreased and it is easier to cough up, appetite has increased, food intake has increased, and bowel movements are smooth. The effect is obvious. Continue to give the original prescription for 7 more doses, with the same method of administration as before. Instruct the patient to do aerobic exercise to increase lung capacity.

[0033] Third visit: The patient reported significant relief from cough and wheezing, no significant sputum, no chest tightness, good appetite, significantly improved mental state, and disappearance of fatigue. Follow-up pulmonary function tests: FEV1 / FVC% <70%, FEV1%pred: 83%.

[0034] One year later, the patient reported that the condition was stable and there were no acute exacerbations.

[0035] Example 6 - Clinical Application Case

[0036] Ms. Lin, female, 77 years old, from Wenchang, presented on September 15, 2020, with a history of "recurrent cough with sputum and shortness of breath for 11 years, worsening in the past week." Summary of four diagnostic methods: elderly, female, alert but poor mental state, chronic disease appearance, wheelchair-bound, clear speech, pale yellow complexion, thin build, chest fullness, and shortness of breath. One week prior, she developed a cough with yellow, sticky sputum that was difficult to expectorate due to weather changes, shortness of breath, which worsened with activity, chest tightness, general weakness, poor appetite and sleep, constipation (absent for 2 days), red tongue with a thin yellow coating, and a slippery pulse. Past medical history: 7-year history of chronic obstructive pulmonary disease (COPD) and cerebral infarction. She routinely received inhaled budesonide and ipratropium bromide nebulizer therapy. Physical examination of the lungs: barrel chest, widened intercostal spaces, coarse breath sounds in both lungs, obvious dry rales in both lungs, and a few moist rales in the lower lung fields. Electrocardiogram was normal. Lung function: FEV1 / FVC% <70%, FEV1%pred: 58%. Blood routine: WBC: 9.6×10 9 / L: NEU% 77.5%; CRP: 22 mg / L; IL6: 11.2 ng / L. No significant abnormalities were found in liver and kidney function, cardiac function, or the six electrolytes.

[0037] Western medicine diagnosis: Acute exacerbation of chronic obstructive pulmonary disease; Traditional Chinese medicine diagnosis: Lung distension, phlegm-heat obstructing the lungs with spleen deficiency. Treatment principle: Clear lung heat and resolve phlegm, relieve cough and asthma. Prescription: 10g of honey-processed ephedra, 10g of earthworm, 10g of bitter almond, 10g of mulberry bark, 15g of coltsfoot flower, 15g of stemona root, 10g of platycodon root, 10g of prepared pinellia tuber, 10g of tangerine peel, 10g of ginkgo, 15g of scutellaria root, 15g of perilla seed, 30g of trichosanthes peel, 10g of angelica root, 10g of belamcanda rhizome, 10g of licorice root, 15g of bupleurum root, 15g of poria cocos. 7 doses in total. Granules / powder, dissolved thoroughly in 100ml-150ml of boiling water until no sediment remains. Oral administration, one dose per day, divided into two doses, taken warm after breakfast and dinner. Patients are advised to take medication on time, avoid getting cold, and get adequate rest. Patients are instructed to return for a follow-up visit in half a month.

[0038] Second visit: The patient reported coughing up a lot of pale yellow sputum that was easy to cough up, and that his shortness of breath had improved compared to before. His appetite had increased and his bowel movements were normal. The treatment effect was significant. The original prescription was continued for 7 more doses, with the same method of administration as before. The patient was also instructed on pulmonary rehabilitation therapy to improve lung function.

[0039] Third visit: The patient reported occasional cough, mainly dry cough, without significant wheezing, chest tightness, or fatigue, and with a good appetite. Repeat pulmonary function tests: FEV1 / FVC% <70%, FEV1%pred: 75%.

[0040] Six months later, the patient reported that the condition was stable and there were no acute exacerbations.

[0041] Example 7 - Clinical Study

[0042] 1. Collect basic case information

[0043] One hundred and forty COPD patients, aged 40 to 80 years, regardless of gender, with pulmonary function ranging from grade I to III, and diagnosed with phlegm-heat obstructing the lungs according to traditional Chinese medicine, were enrolled. They were randomly assigned to study group 1 and study group 2, with 70 patients in each group.

[0044] 2. Clinical manifestations of the disease

[0045] Common clinical manifestations include chronic cough, sputum production, shortness of breath or wheezing, with shortness of breath usually worsening after activity. The shortness of breath progressively worsens year by year, and in the late stage, wheezing may occur with exertion, loss of appetite, weight loss, malnutrition, etc.

[0046] 3. Clinical diagnostic criteria

[0047] (1) Medical history: a history of recurrent chronic bronchitis for many years, or a history of smoking or exposure to air pollution;

[0048] (2) Clinical manifestations: chronic cough, sputum production, shortness of breath or wheezing, usually worse after activity;

[0049] (3) Physical signs: The anteroposterior diameter of the chest gradually increases, and the chest bulges in the later stage. Auscultation reveals decreased breath sounds and prolonged expiration.

[0050] (4) Pulmonary function test: FEV1 / FVC < 70% after inhalation of bronchodilator;

[0051] (5) Chest X-ray: suggests signs of emphysema;

[0052] (6) Exclude other diseases.

[0053] The fourth condition is that pulmonary function testing is a necessary condition for diagnosing COPD.

[0054] 4. Treatment methods and course of treatment

[0055] Study group 1 was given the herbal medicine according to the formula in Example 1, and study group 2 was given the herbal medicine according to the formula in Example 2. Each herb in the formula was in granule form. The method of administration was as follows: dissolve the herbs in 100ml-150ml of boiling water and stir thoroughly until no sediment remains. Take orally, one dose per day, divided into two doses, half an hour after breakfast and dinner. One course of treatment is 14 days, and 1 to 3 courses of treatment are required.

[0056] 5. Criteria for judging therapeutic efficacy

[0057] This plan was drafted with reference to the "Guiding Principles for Clinical Research of New Traditional Chinese Medicine Drugs". A syndrome score will be calculated, consisting of the total score of the primary TCM symptom plus the secondary symptom score. The higher the score, the more severe the patient's condition.

[0058] Clinical control: All symptoms of COPD have disappeared or almost completely resolved, and the degree of symptom improvement is ≥95%;

[0059] Significant effect: All symptoms of COPD are significantly reduced, with 70% ≤ symptom improvement < 95%;

[0060] Effective: All symptoms of COPD improved, with 30% ≤ symptom improvement < 70%;

[0061] Ineffective: Cough and wheezing worsen, symptoms do not improve, symptom score <30%, or even a series of related complications occur.

[0062] 6. Clinical efficacy results

[0063] Table 1 Clinical efficacy results of COPD treatment

[0064]

[0065] The above clinical research results show that the traditional Chinese medicine formula of this invention has good clinical efficacy in treating COPD of the phlegm-heat obstructing the lungs type, with high clinical control and significant efficacy rates. The combined clinical control rate and significant efficacy rate are 81.43% to 87.14%, and the overall effective rate is high (98.6% to 100%). Among them, the efficacy of study group 2 is generally better than that of study group 1.

[0066] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for clearing the lungs and relieving asthma, characterized in that, It is prepared from the following raw materials in the following weight proportions: Ephedra 8-12g, Earthworm 8-12g, Bitter Almond 8-12g, Mulberry Bark 8-12g, Coltsfoot Flower 13-18g, Stemona 13-18g, Platycodon 8-12g, Prepared Pinellia 8-12g, Citrus Reticulata Peel 8-12g, Ginkgo 8-12g, Scutellaria 13-18g, Perilla Seed 13-18g, Trichosanthes Peel 25-35g, Peucedanum praeruptorum 8-12g, Belamcanda chinensis 8-12g, Licorice 8-12g, Bupleurum 13-18g, Poria 13-18g.

2. The traditional Chinese medicine composition for clearing the lungs and relieving asthma according to claim 1, characterized in that, It is prepared from the following raw materials in the following weight proportions: Ephedra 9-11g, Earthworm 9-11g, Bitter Almond 9-11g, Mulberry Bark 9-11g, Coltsfoot Flower 14-16g, Stemona 14-16g, Platycodon 9-11g, Prepared Pinellia 9-11g, Citrus Reticulata Peel 9-11g, Ginkgo 9-11g, Scutellaria 14-16g, Perilla Seed 14-16g, Trichosanthes Peel 28-32g, Peucedanum praeruptorum 9-11g, Belamcanda chinensis 9-11g, Licorice 9-11g, Bupleurum 14-16g, Poria 14-16g.

3. The traditional Chinese medicine composition for clearing the lungs and relieving asthma according to claim 2, characterized in that, It is prepared from the following raw materials in the indicated weight proportions: Ephedra 10g, Earthworm 10g, Bitter Almond 10g, Mulberry Bark 10g, Coltsfoot Flower 15g, Stemona 15g, Platycodon 10g, Prepared Pinellia 10g, Citrus Reticulata Peel 10g, Ginkgo 10g, Scutellaria 15g, Perilla Seed 15g, Trichosanthes Peel 30g, Peucedanum praeruptorum 10g, Belamcanda chinensis 10g, Licorice 10g, Bupleurum 15g, Poria 15g.

4. The traditional Chinese medicine composition for clearing the lungs and relieving asthma according to any one of claims 1-3, characterized in that, The ephedra mentioned is honey-processed ephedra.

5. A granular medicine for clearing the lungs and relieving asthma, characterized in that, It is prepared from the traditional Chinese medicine composition according to any one of claims 1-3.

6. The use of the traditional Chinese medicine composition according to any one of claims 1-3 in the preparation of a medicament for treating chronic obstructive pulmonary disease.

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