Skin-lightening and beauty-enhancing composition containing glabrous fruit licorice extract and moisturizing lotion

Abstract

The present invention relates to the technical field of daily-use cosmetics, and specifically discloses a skin-lightening and beauty-enhancing composition containing glabrous licorice extract and a moisturizing water. Among them, a skin-lightening and beauty-enhancing composition containing glabrous licorice extract comprises the following components: angelica extract; dictamnus root bark extract; glabrous licorice extract; gynostemma pentaphyllum extract; codonopsis tangshen root extract; rehmannia root extract; preservative; solvent. The moisturizing water of the skin-lightening and beauty-enhancing composition containing glabrous licorice extract comprises the following components: the skin-lightening and beauty-enhancing composition containing glabrous licorice extract; humectant; emulsifier; chelating agent; preservative; solvent. The preparation method of the moisturizing water is: adding and stirring and mixing evenly in a specific order to obtain the moisturizing water of the skin-lightening and beauty-enhancing composition containing glabrous licorice extract. The composition of the present invention has the advantages of good whitening effect, excellent anti-aging effect, and can deeply penetrate the skin. At the same time, the preparation method of the present invention also has the advantages of being simple and convenient and easy to industrialize production.

Description

Technical Field

[0001] The present invention relates to the technical field of daily-use cosmetics, and particularly to a skin-lightening and beauty-enhancing composition containing glabridin and a moisturizing lotion. Background Art

[0002] Melanocytes exist in the basal layer of the human epidermis. In melanocytes, tyrosine is gradually oxidized to dopa, dopaquinone, dopachrome, etc. under the catalytic action of tyrosinase, and then pigment granules are formed. After the accumulation of pigment granules, it will cause the facial skin to become dull, yellowish, and lack a transparent luster. With the increasing improvement of living standards, the pursuit of beauty by women is also getting higher and higher. As an important feature of beauty, fair and delicate skin has increasingly become the goal pursued by women.

[0003] A moisturizing lotion is a transparent liquid cosmetic that is applied to the surface of facial skin to maintain skin health and is an essential product for daily beauty care. However, most of the moisturizing lotions on the market that can brighten the skin tone add components such as salicylic acid to soften the cutin to promote the metabolism of the cutin layer, and then add direct whitening fluorescent skin-lightening factors, so that the facial skin can show a whitening effect in a short time. However, this way of brightening by accelerating the metabolism of the cutin layer and promoting the shedding of the aging cutin layer can only act on the facial skin, and the melanin in the basal layer of the human epidermis itself has not been improved, and the effect of long-term skin lightening and beauty enhancement cannot be achieved. Therefore, there is still room for improvement. Summary of the Invention

[0004] In order to enable the moisturizing lotion to improve the skin-lightening effect for a long time, the present application provides a skin-lightening and beauty-enhancing composition containing glabridin and a moisturizing lotion.

[0005] In a first aspect, the present application provides a skin-lightening and beauty-enhancing composition containing glabridin, adopting the following technical solution:

[0006] A skin-lightening and beauty-enhancing composition containing glabridin, comprising the following components in mass percentages:

[0007] Angelica sinensis extract 9 - 11%;

[0008] Dictamnus dasycarpus Turcz. root bark extract 4 - 6%;

[0009] Glabridin 14 - 15%;

[0010] Gynostemma pentaphyllum extract 9 - 11%;

[0011] Codonopsis tangshen Oliv. root extract 0.4 - 0.6%;

[0012] Rehmannia glutinosa Libosch. root extract 20 - 22%;

[0013] Preservative 4 - 6%;

[0014] The remainder is the solvent.

[0015] By adopting the above technical solution, the synergistic compounding of angelica extract and glabrous licorice root extract is beneficial to inhibiting the activity of tyrosinase during the melanin generation process, reducing the generation of melanin in the skin; it is also beneficial to significantly improving the fading of obvious melanin that has already appeared on the facial skin, achieving the effects of lightening freckles and dullness, and making the skin color more uniform and bright.

[0016] By adding gynostemma pentaphyllum extract, cortex dictamni extract, codonopsis tangshen root extract, and rehmannia root extract, it is beneficial to scavenge free radicals, protect skin cells from oxidative stress damage, and at the same time reduce the oxidative degradation of collagen and elastin, which is beneficial to delaying the process of skin oxidative aging, enabling the skin to maintain a plump, elastic, and shiny state for a long time.

[0017] By adding the synergistic compounding of gynostemma pentaphyllum extract, cortex dictamni extract, codonopsis tangshen root extract, rehmannia root extract with angelica extract and glabrous licorice root extract, the percutaneous permeability of the composition is improved, enabling the composition to penetrate into the dermis of the skin, further enhancing the whitening and anti-aging effects, and keeping the facial skin in a bright, white, and plump state.

[0018] In the second aspect, the present application provides a preparation method of a skin-lightening and beauty-enhancing composition containing glabrous licorice root extract, adopting the following technical solution:

[0019] A preparation method of a skin-lightening and beauty-enhancing composition containing glabrous licorice root extract is as follows:

[0020] Accurately weigh each component raw material, add angelica extract, cortex dictamni extract, glabrous licorice root extract, gynostemma pentaphyllum extract, codonopsis tangshen root extract, rehmannia root extract, preservative, and solvent into a container, and stir and mix evenly to obtain a skin-lightening and beauty-enhancing composition containing glabrous licorice root extract.

[0021] By adopting the above technical solution, mixing the above components in a certain order is beneficial to promoting the mutual interweaving, penetration, and fusion of each component, and preparing a skin-lightening and beauty-enhancing composition containing glabrous licorice root extract with good whitening effect, excellent anti-aging effect, capable of deeply penetrating the skin, and long-acting skin brightening.

[0022] In the third aspect, the present application provides a moisturizing water of a skin-lightening and beauty-enhancing composition containing glabrous licorice root extract, adopting the following technical solution:

[0023] A moisturizing water of a skin-lightening and beauty-enhancing composition containing glabrous licorice root extract includes the following components in mass percentage:

[0024] The skin-lightening and beauty-enhancing composition containing glabrous licorice root extract is 8 - 11%;

[0025] Water-soluble jojoba ester 0.05 - 0.15%;

[0026] Disodium EDTA 0.05 - 0.15%;

[0027] Humectant 8.5 - 9.5%;

[0028] Preservative 1 - 1.5%;

[0029] The balance is solvent.

[0030] By adopting the above technical solution, adding the brightening and beautifying composition containing glabridin extract to the moisturizing water is beneficial to improving the inhibition of tyrosinase activity by the moisturizing water, blocking the formation of melanin, and then delaying skin aging by enhancing the antioxidant property of the moisturizing water, so as to achieve the effects of brightening and beautifying the skin; meanwhile, adding a humectant is beneficial to better deeply hydrating the skin, increasing and maintaining the moisture of facial skin, and further enhancing the effect of the moisturizing water in moistening and caring for the skin.

[0031] Preferably, the humectant includes one or more of allantoin, betaine, propylene glycol, sodium hyaluronate, and D-panthenol.

[0032] Preferably, the humectant is composed of allantoin, betaine, propylene glycol, sodium hyaluronate, and D-panthenol mixed in a mass ratio of (0.1 - 0.3):(0.5 - 1.5):(7 - 8):(0.005 - 0.015):(0.1 - 0.3).

[0033] By adopting the above technical solution, using allantoin, betaine, propylene glycol, sodium hyaluronate, and D-panthenol in specific proportions synergistically as a humectant is beneficial to providing sufficient moisture to the skin, keeping the skin plump and moist; meanwhile, it is also beneficial to enhancing the transdermal permeability of the moisturizing water and further improving the whitening and brightening effect of the moisturizing water.

[0034] Preferably, the preservative includes one or more of p-hydroxyacetophenone, benzyl alcohol, phenoxyethanol, and ethylhexylglycerin.

[0035] Preferably, the preservative is composed of phenoxyethanol and ethylhexylglycerin mixed in a mass ratio of (0.5 - 1.5):1.

[0036] By adopting the above technical solution, adding phenoxyethanol and ethylhexylglycerin in specific proportions synergistically as a preservative is beneficial to inhibiting the growth of microorganisms, enabling the moisturizing water to maintain effectiveness for a long time; meanwhile, it is also beneficial to further improving the moisturizing effect of the moisturizing water and keeping the skin plump and moist.

[0037] Fourthly, the present application provides a method for preparing a moisturizing lotion of a skin-lightening and beauty-enhancing composition containing glabridin extract, adopting the following technical solutions:

[0038] A method for preparing a moisturizing lotion of a skin-lightening and beauty-enhancing composition containing glabridin extract, comprising the following steps:

[0039] Step 1: Clean and disinfect the equipment and tools required in the preparation method;

[0040] Step 2: Add a skin-lightening and beauty-enhancing composition containing glabridin extract, a solvent, a moisturizer, water-soluble jojoba ester, and EDTA disodium into a container, raise the temperature to 84 - 86 °C, stir evenly at a speed of 200 - 500 r / min, then keep stirring for 9 - 11 min while maintaining the temperature, reduce the speed to 50 - 100 r / min and simultaneously perform vacuum defoaming for 9 - 11 min;

[0041] Step 3: Then add a preservative into the container, stir and mix evenly to obtain a moisturizing lotion of a skin-lightening and beauty-enhancing composition containing glabridin extract.

[0042] By adopting the above technical solutions, controlling the addition sequence and reaction temperature of each component raw material is beneficial to the uniform mixing of each component raw material, enabling each component to fully exert its beneficial effects and improving the skin-lightening and beauty-enhancing efficacy of the moisturizing lotion.

[0043] In summary, the present application has the following beneficial effects:

[0044] 1. By adding Angelica sinensis extract and glabridin extract in a synergistic combination, it is beneficial to inhibit the activity of tyrosinase during the melanin generation process, reducing the generation of melanin in the skin; it is also beneficial to significantly improve the regression of obvious melanin that has already appeared on the facial skin, achieving the effects of fading spots and dullness and making the skin color more uniform and bright. By adding Gynostemma pentaphyllum extract, Dictamnus dasycarpus root extract, Codonopsis tangshen root extract, and Rehmannia glutinosa root extract, it is beneficial to scavenge free radicals, protect skin cells from oxidative stress damage, and at the same time reduce the oxidative degradation of collagen and elastin, which is beneficial to delaying the process of skin oxidative aging and enabling the skin to maintain a plump, elastic, and shiny state for a long time. By adding Gynostemma pentaphyllum extract, Dictamnus dasycarpus root extract, Codonopsis tangshen root extract, and Rehmannia glutinosa root extract in a synergistic combination with Angelica sinensis extract and glabridin extract, it improves the transdermal permeability of the composition, enabling the composition to penetrate into the dermis of the skin and further enhancing the whitening and anti-aging effects, keeping the facial skin in a bright white and plump state.

[0045] 2. By using allantoin, betaine, propylene glycol, sodium hyaluronate, and D-panthenol in a specific ratio as moisturizers in combination, it is beneficial to provide sufficient moisture to the skin, keeping the skin plump and hydrated; at the same time, it is also beneficial to enhance the transdermal permeability of the moisturizing water, further improving the skin-whitening and brightening effect of the moisturizing water.

[0046] 3. By using phenoxyethanol and ethylhexylglycerin in a specific ratio as a preservative in combination, it is beneficial to inhibit the growth of microorganisms, enabling the moisturizing water to maintain its effectiveness for a long time; at the same time, it is also beneficial to further improve the moisturizing effect of the moisturizing water, keeping the skin plump and hydrated. Detailed implementation manners

[0047] The following further elaborates on this application with reference to examples.

[0048] In the following examples and comparative examples, all raw materials are commercially available, specifically as follows:

[0049] The witch hazel extract is purchased from Fufeng Sinuote Biotechnology Co., Ltd.;

[0050] The lotus extract is purchased from Wuhan Xinxin Jiali Biotechnology Co., Ltd.;

[0051] The mulberry root bark extract is purchased from Xi'an Xintuo Biological Products Co., Ltd.;

[0052] The CAS number of the angelica extract is 443-01-0;

[0053] The CAS number of the cortex dictamni extract is 90045-36-6;

[0054] The CAS number of the glabrous licorice root extract is 59870-68-7;

[0055] The CAS number of the gynostemma pentaphyllum extract is 15588-68-8;

[0056] The CAS number of the codonopsis tangshen root extract is 141726-23-0;

[0057] The CAS number of the rehmannia root extract is 928-624-7;

[0058] The CAS number of the grape seed extract is 84929-27-1;

[0059] The CAS number of the moutan bark extract is 552-41-0;

[0060] The CAS number of the resveratrol extract is 501-36-0;

[0061] The CAS number of octanoyl hydroxamic acid is 7377-03-9;

[0062] The CAS number of sodium benzoate is 532-32-1;

[0063] The CAS number of butanediol is 584-03-2;

[0064] The CAS number of hexanediol is 629-11-8;

[0065] The CAS number of allantoin is 97-59-6;

[0066] The CAS number of betaine is 107-43-7;

[0067] The CAS number of propylene glycol is 57-55-6;

[0068] The CAS number of sodium hyaluronate is 9067-32-7;

[0069] The CAS number of D-panthenol is 81-13-0;

[0070] The CAS number of methylhydantoin-2-imide is 60-27-5;

[0071] The CAS number of glutamic acid is 56-86-0;

[0072] The CAS number of butanediol is 25265-75-2;

[0073] The CAS number of hyaluronic acid is 9004-61-9;

[0074] The CAS number of glycerol is 56-81-5;

[0075] The CAS number of water-soluble jojoba ester is 61789-91-1;

[0076] The CAS number of EDTA disodium is 139-33-3;

[0077] The CAS number of phenoxyethanol is 122-99-6;

[0078] The CAS number of ethylhexylglycerin is 70445-33-9.

[0079] Example 1

[0080] The example of this application discloses a skin brightening and beauty enhancing composition containing glabrous licorice extract, which is composed of the following components by mass: 90 g of angelica extract; 40 g of cortex dictamni extract; 140 g of glabrous licorice extract; 90 g of gynostemma pentaphyllum extract; 4 g of codonopsis tangshen root extract; 200 g of rehmannia root extract; 40 g of preservative; 396 g of solvent.

[0081] In this example, the preservative is hexanediol; the solvent is butanediol.

[0082] The embodiments of the present application also disclose a preparation method of a skin brightening and beauty enhancing composition containing glabrous licorice root extract, which is as follows:

[0083] Add angelica extract, cortex dictamni extract, glabrous licorice root extract, gynostemma pentaphyllum extract, codonopsis tangshen root extract, rehmannia root extract, hexylene glycol and butylene glycol into an emulsifying pot in sequence, and stir and mix evenly at a rotation speed of 50 r / min to obtain a skin brightening and beauty enhancing composition containing glabrous licorice root extract.

[0084] Example 2

[0085] The embodiments of the present application disclose a skin brightening and beauty enhancing composition containing glabrous licorice root extract, which is composed of the following components by mass: 110 g of angelica extract; 60 g of cortex dictamni extract; 150 g of glabrous licorice root extract; 110 g of gynostemma pentaphyllum extract; 6 g of codonopsis tangshen root extract; 220 g of rehmannia root extract; 60 g of preservative; 284 g of solvent.

[0086] In this embodiment, the preservative is hexylene glycol; the solvent is butylene glycol.

[0087] The embodiments of the present application also disclose a preparation method of a skin brightening and beauty enhancing composition containing glabrous licorice root extract, which is as follows:

[0088] Add angelica extract, cortex dictamni extract, glabrous licorice root extract, gynostemma pentaphyllum extract, codonopsis tangshen root extract, rehmannia root extract, hexylene glycol and butylene glycol into an emulsifying pot in sequence, and stir and mix evenly at a rotation speed of 50 r / min to obtain a skin brightening and beauty enhancing composition containing glabrous licorice root extract.

[0089] Example 3

[0090] The embodiments of the present application disclose a skin brightening and beauty enhancing composition containing glabrous licorice root extract, which is composed of the following components by mass: 100 g of angelica extract; 50 g of cortex dictamni extract; 145 g of glabrous licorice root extract; 100 g of gynostemma pentaphyllum extract; 5 g of codonopsis tangshen root extract; 210 g of rehmannia root extract; 50 g of preservative; 340 g of solvent.

[0091] In this embodiment, the preservative is hexylene glycol; the solvent is butylene glycol.

[0092] The embodiments of the present application also disclose a preparation method of a skin brightening and beauty enhancing composition containing glabrous licorice root extract, which is as follows:

[0093] Add angelica extract, cortex dictamni extract, glabrous licorice root extract, gynostemma pentaphyllum extract, codonopsis tangshen root extract, rehmannia root extract, hexylene glycol and butylene glycol into an emulsifying pot in sequence, and stir and mix evenly at a rotation speed of 50 r / min to obtain a skin brightening and beauty enhancing composition containing glabrous licorice root extract.

[0094] Comparative Example 1

[0095] The difference from Example 3 is that the Angelica sinensis extract is replaced with an equal amount of grape seed extract.

[0096] Comparative Example 2

[0097] The difference from Example 3 is that the Glycyrrhiza glabra extract is replaced with an equal amount of Cortex Moutan extract.

[0098] Comparative Example 3

[0099] The difference from Example 3 is that the Dictamnus dasycarpus Turcz. root bark extract is replaced with an equal amount of Morus alba L. root bark extract.

[0100] Comparative Example 4

[0101] The difference from Example 3 is that the Gynostemma pentaphyllum extract is replaced with an equal amount of Veratrum grandiflorum Loes. extract.

[0102] Comparative Example 5

[0103] The difference from Example 3 is that the Codonopsis tangshen Oliv. root extract is replaced with an equal amount of Hamamelis virginiana L. extract.

[0104] Comparative Example 6

[0105] The difference from Example 3 is that the Rehmannia glutinosa Libosch. root extract is replaced with an equal amount of Nelumbo nucifera Gaertn. extract.

[0106] Application Example 1

[0107] This application example discloses a moisturizing water of a skin brightening and beauty enhancing composition containing Glycyrrhiza glabra extract, which is composed of the following components by mass:

[0108] Skin brightening and beauty enhancing composition containing Glycyrrhiza glabra extract 80 g; water-soluble jojoba ester 0.5 g; EDTA disodium 0.5 g; humectant 85 g; preservative 10 g; solvent 824 g.

[0109] In this application example, the skin brightening and beauty enhancing composition containing Glycyrrhiza glabra extract is prepared as in Example 1.

[0110] The humectant is composed of allantoin, betaine, propylene glycol, sodium hyaluronate, and D-panthenol mixed in a mass ratio of 0.1:0.5:7:0.005:0.1, that is, the humectant is composed of 1.1 g of allantoin, 5.52 g of betaine, 77.22 g of propylene glycol, 0.06 g of hyaluronic acid, and 1.1 g of D-panthenol; the preservative is composed of phenoxyethanol and ethylhexylglycerin mixed in a mass ratio of 0.5:1, that is, the preservative is composed of 3.3 g of phenoxyethanol and 6.7 g of ethylhexylglycerin.

[0111] The application example also discloses a preparation method of a moisturizing lotion of a skin - brightening and beauty - enhancing composition containing glabridin extract, which comprises the following steps:

[0112] Step 1: Clean and disinfect the equipment and tools required in the preparation method;

[0113] Step 2: Add the skin - brightening and beauty - enhancing composition containing glabridin extract, solvent, moisturizer, water - soluble jojoba ester, and EDTA - disodium into a stirrer, raise the temperature to 84 °C, stir for 10 minutes under the condition of a rotation speed of 200 r / min, then stir while maintaining the temperature for 9 min, adjust the rotation speed to 50 r / min, and carry out vacuum defoaming for 9 min;

[0114] Step 3: Add a preservative into the stirrer and stir at a rotation speed of 75 r / min for 5 minutes to obtain a moisturizing lotion of a skin - brightening and beauty - enhancing composition containing glabridin extract.

[0115] Application Example 2

[0116] The application example of the present application discloses a moisturizing lotion of a skin - brightening and beauty - enhancing composition containing glabridin extract, which is composed of the following components by mass:

[0117] 110 g of the skin - brightening and beauty - enhancing composition containing glabridin extract; 1.5 g of water - soluble jojoba ester; 1.5 g of EDTA - disodium; 95 g of moisturizer; 15 g of preservative; 777 g of solvent.

[0118] In this application example, the skin - brightening and beauty - enhancing composition containing glabridin extract is obtained by the preparation in Example 1.

[0119] The moisturizer is composed of allantoin, betaine, propylene glycol, sodium hyaluronate, and D - panthenol mixed in a mass ratio of 0.3:1.5:8:0.015:0.3, that is, the moisturizer is composed of 2.8 g of allantoin, 14.1 g of betaine, 75.2 g of propylene glycol, 0.1 g of hyaluronic acid, and 2.8 g of D - panthenol; the preservative is composed of phenoxyethanol and ethylhexylglycerin mixed in a mass ratio of 1.5:1, that is, the preservative is composed of 9 g of phenoxyethanol and 6 g of ethylhexylglycerin.

[0120] The application example of the present application also discloses a preparation method of a moisturizing lotion of a skin - brightening and beauty - enhancing composition containing glabridin extract, which comprises the following steps:

[0121] Step 1: Clean and disinfect the equipment and tools required in the preparation method;

[0122] Step 2: Add the brightening and beauty - enhancing composition containing glabridin extract, solvent, humectant, water - soluble jojoba ester, and disodium EDTA into the stirrer, raise the temperature to 86 °C, stir for 10 minutes at a rotation speed of 500 r / min, then stir while maintaining the temperature for 11 min, adjust the rotation speed to 100 r / min, and conduct vacuum defoaming for 11 min;

[0123] Step 3: Add the preservative into the stirrer and stir for 5 minutes at a rotation speed of 75 r / min to obtain a moisturizing water of the brightening and beauty - enhancing composition containing glabridin extract.

[0124] Application Example 3

[0125] This application example discloses a moisturizing water of a brightening and beauty - enhancing composition containing glabridin extract, which is composed of the following components by mass:

[0126] 100 g of the brightening and beauty - enhancing composition containing glabridin extract; 1 g of water - soluble jojoba ester; 1 g of disodium EDTA; 90 g of humectant; 13 g of preservative; 795 g of solvent.

[0127] In this application example, the brightening and beauty - enhancing composition containing glabridin extract is prepared as in Example 1.

[0128] The humectant is composed of allantoin, betaine, propylene glycol, sodium hyaluronate, and D - panthenol mixed in a mass ratio of 0.2:1:7.5:0.01:0.2, that is, the humectant is composed of 2 g of allantoin, 10.1 g of betaine, 75.8 g of propylene glycol, 0.1 g of hyaluronic acid, and 2 g of D - panthenol; the preservative is composed of phenoxyethanol and ethylhexylglycerin mixed in a mass ratio of 1:1, that is, the preservative is composed of 6.5 g of phenoxyethanol and 6.5 g of ethylhexylglycerin.

[0129] This application example also discloses a preparation method of a moisturizing water of a brightening and beauty - enhancing composition containing glabridin extract, which includes the following steps:

[0130] Step 1: Clean and disinfect the equipment and tools required in the preparation method;

[0131] Step 2: Add the brightening and beauty - enhancing composition containing glabridin extract, solvent, humectant, water - soluble jojoba ester, and disodium EDTA into the stirrer, raise the temperature to 85 °C, stir for 10 minutes at a rotation speed of 350 r / min, then stir while maintaining the temperature for 10 min, set the rotation speed to 75 r / min, and then conduct vacuum defoaming for 10 min;

[0132] Step 3: Add the preservative into the stirrer and stir for 5 minutes at a rotation speed of 75 r / min to obtain a moisturizing water of a brightening and beauty - enhancing composition containing glabridin extract.

[0133] Application Example 4

[0134] The difference from Application Example 3 is that the skin-lightening and beauty-enhancing composition containing glabridin extract is obtained by the preparation of Example 2.

[0135] Application Example 5

[0136] The difference from Application Example 3 is that the skin-lightening and beauty-enhancing composition containing glabridin extract is obtained by the preparation of Example 3.

[0137] Application Example 6

[0138] The difference from Application Example 5 is that allantoin is replaced with an equal amount of methylhydantoin-2-imide.

[0139] Application Example 7

[0140] The difference from Application Example 5 is that betaine is replaced with an equal amount of glutamic acid.

[0141] Application Example 8

[0142] The difference from Application Example 5 is that propylene glycol is replaced with an equal amount of butylene glycol.

[0143] Application Example 9

[0144] The difference from Application Example 5 is that sodium hyaluronate is replaced with an equal amount of hyaluronic acid.

[0145] Application Example 10

[0146] The difference from Application Example 5 is that D-panthenol is replaced with an equal amount of glycerol.

[0147] Application Example 11

[0148] The difference from Application Example 5 is that phenoxyethanol is replaced with an equal amount of sodium benzoate.

[0149] Application Example 12

[0150] The difference from Application Example 5 is that ethylhexylglycerin is replaced with an equal amount of octanoyl hydroxamic acid.

[0151] Comparative Application Example 1

[0152] The difference from Application Example 5 is that the skin-lightening and beauty-enhancing composition containing glabridin extract is obtained by the preparation of Comparative Example 1.

[0153] Comparative Application Example 2

[0154] The difference from Application Example 5 is that the skin-lightening and beauty-enhancing composition containing glabridin extract is obtained by the preparation of Comparative Example 2.

[0155] Comparative Application Example 3

[0156] The difference from Application Example 5 is that the skin brightening and beauty enhancing composition containing glabridin extract is obtained by the preparation of Comparative Example 3.

[0157] Comparative Application Example 4

[0158] The difference from Application Example 5 is that the skin brightening and beauty enhancing composition containing glabridin extract is obtained by the preparation of Comparative Example 4.

[0159] Comparative Application Example 5

[0160] The difference from Application Example 5 is that the skin brightening and beauty enhancing composition containing glabridin extract is obtained by the preparation of Comparative Example 5.

[0161] Comparative Application Example 6

[0162] The difference from Application Example 5 is that the skin brightening and beauty enhancing composition containing glabridin extract is obtained by the preparation of Comparative Example 6.

[0163] Experiment 1 Tyrosinase Inhibition Rate

[0164] Add 3 mL of 0.05% L-tyrosine by mass fraction, 4 mL of phosphate buffer with a pH of 6.8, and 0.3 mL of the moisturizing water prepared in the above application examples and comparative application examples into a 15 mL centrifuge tube in sequence, shake well, place it in a water bath at 37 °C for water bath heating for 10 min, then add 1 mL of 500 U / mL tyrosinase, continue heating for 5 min, take out the centrifuge tube and centrifuge for 5 min under the condition of a rotation speed of 12,000 r / min, and finally use an ultraviolet spectrophotometer (UV-1801 of Shanghai Mepuda Company) to measure the absorbance value of the above solution at 475 nm, and the obtained absorbance value is A1; replace the moisturizing water with an equal amount of phosphate buffer, and the absorbance value measured at 475 nm is A2, and calculate according to the following formula:

[0165]

[0166] The above experimental detection data are shown in Table 1 in detail.

[0167] Experiment 2 Free Radical Scavenging Rate

[0168] Add 2 mL of the moisturizing water prepared in the above application examples and comparative application examples and 4 mL of DPPH free radical solution with a mass concentration of 0.05 mg / mL into a colorimetric tube, make up the volume to 10 mL with ultrapure water, then place it in the dark for light-shielding reaction for 50 minutes, and then use an ultraviolet spectrophotometer to measure the absorbance at 517 nm, denoted as A2, and use a 0.5 mg / mL vitamin C solution as a positive control, denoted as A1, and calculate the free radical scavenging rate according to the following formula.

[0169] Experiment 3 Percutaneous Permeation Rate

[0170] Take the mouse skin frozen at -20 °C, thaw it, and rinse the mouse skin 3 times with normal saline. Then, take 0.5 mL of the moisturizing water prepared in the above application examples and comparative application examples and evenly apply it on the surface of the stratum corneum of the mouse skin. The application area is 4 cm * 4 cm, and gently pat the mouse skin with hands for 2 minutes to allow the mouse skin to fully absorb the moisturizing water. Then, place the mouse skin on the diffusion cell of the transdermal diffusion tester, with the skin stratum corneum facing up and the inner layer of the skin in close contact with the receiving liquid; set the temperature of the transdermal diffusion tester to 37 °C and the stirring speed to 350 r / min; then take 0.5 mL of propylene glycol and evenly apply it on the surface of the mouse skin that has been applied with the moisturizing water. After 3 hours, take 1 mL of the receiving liquid from the receiving pool and filter it using a 0.45 μm microporous membrane to obtain a sample. Use high-performance liquid chromatography to determine the propylene glycol in the sample. The mass concentration of propylene glycol is C (μg / mL), and calculate the cumulative transdermal permeation amount Q (μg / cm 2 ).

[0171] The above experimental detection data are shown in Table 1 for details.

[0172] Experiment 4

[0173] Randomly select 90 female volunteers with long-term staying up late in their living habits, and with dry, dull, and emaciated cheeks on their facial skin. The age range is 30 - 35 years old, and the volunteers are randomly divided into 18 groups with 5 people in each group. Each group of volunteers uses the moisturizing water prepared in the above application examples and comparative application examples respectively after cleansing their faces every morning and evening. Each time, take 1.5 mL and evenly apply it on both sides of the cheeks. Use it continuously for 30 days, observe and record the skin condition of the volunteers, and use a skin tester (EHANG, South Korea, EH-990U) to measure the skin water content of the volunteers; starting from the 31st day, stop using the above moisturizing water and switch to a commercially available moisturizing water, and use it continuously for 10 days, observe and record the changes in the skin condition of the volunteers.

[0174] The above experimental detection data are shown in Table 1 for details.

[0175] Table 1

[0176]

[0177]

[0178] According to the data comparison between Application Example 5 and Comparative Application Examples 1-6 in Table 1, by replacing Angelica sinensis extract and Glycyrrhiza glabra extract with equal amounts of grape seed extract and mulberry root bark extract respectively, the inhibition rate of the prepared moisturizing water on tyrosinase decreases, indicating that by adding Angelica sinensis extract and Glycyrrhiza glabra extract in a synergistic combination, it is beneficial to inhibit the activity of tyrosinase during the melanin generation process, reducing the melanin production in the skin, achieving the effect of lightening age spots and dullness, and making the skin color more uniform and bright. By replacing Gynostemma pentaphyllum extract, Dictamnus dasycarpus Turcz. root bark extract, Codonopsis tangshen root extract, and Rehmannia glutinosa root extract with equal amounts of Paeonia suffruticosa Andr. extract, resveratrol extract, Hamamelis virginiana L. extract, and Nelumbo nucifera Gaertn. extract respectively, the free radical scavenging effect of the prepared moisturizing water decreases, indicating that by adding Gynostemma pentaphyllum extract, Dictamnus dasycarpus Turcz. root bark extract, Codonopsis tangshen root extract, and Rehmannia glutinosa root extract, it is beneficial to scavenge free radicals, protect skin cells from oxidative stress damage, and at the same time reduce the oxidative degradation of collagen and elastin, which is beneficial to delaying the process of skin oxidative aging, enabling the skin to maintain a plump, elastic, and shiny state for a long time. By replacing Angelica sinensis extract, Glycyrrhiza glabra extract, Gynostemma pentaphyllum extract, Dictamnus dasycarpus Turcz. root bark extract, Codonopsis tangshen root extract, and Rehmannia glutinosa root extract with equal amounts of grape seed extract, mulberry root bark extract, Paeonia suffruticosa Andr. extract, resveratrol extract, Hamamelis virginiana L. extract, and Nelumbo nucifera Gaertn. extract respectively, the transdermal permeability of the prepared moisturizing water decreases, and the dull skin color of the volunteers did not improve well after continuous use for 28 days, indicating that by adding Gynostemma pentaphyllum extract, Dictamnus dasycarpus Turcz. root bark extract, Codonopsis tangshen root extract, Rehmannia glutinosa root extract in a synergistic combination with Angelica sinensis extract and Glycyrrhiza glabra extract, the transdermal permeability of the composition is improved, enabling the composition to penetrate into the dermis of the skin, further enhancing the whitening and anti-aging effects, and keeping the facial skin bright, white, and plump.

[0179] According to the data comparison between Application Example 5 and Comparative Application Examples 6-10 in Table 1, by using allantoin, betaine, propylene glycol, sodium hyaluronate, and D-panthenol in a specific ratio as humectants in combination, it is beneficial to provide sufficient moisture to the skin, keeping the skin plump and moisturized; at the same time, it is also beneficial to enhance the transdermal permeability of the moisturizing water, further improving the whitening and skin brightening effect of the moisturizing water.

[0180] According to the data comparison between Application Example 5 and Comparative Application Examples 11-12 in Table 1, by using phenoxyethanol and ethylhexylglycerin in a specific ratio as preservatives in combination, it is beneficial to inhibit the growth of microorganisms, enabling the moisturizing water to maintain effectiveness for a long time; at the same time, it is also beneficial to further improve the moisturizing effect of the moisturizing water, keeping the skin plump and moisturized.

[0181] This specific embodiment is only an interpretation of the present application and does not limit the present application. After reading this specification, those skilled in the art can make modifications to this embodiment that do not contribute creatively as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A moisturizing lotion containing a skin-lightening and beauty-enhancing composition with glabridin extract, characterized in that: Comprising the following components in mass percentages: Skin - brightening and beauty - enhancing composition containing glabrous licorice extract 8 - 11%; Water - soluble jojoba ester 0.05 - 0.15%; EDTA - disodium 0.05 - 0.15%; Humectant 8.5 - 9.5%; Preservative 1 - 1.5%; The balance is solvent; The humectant is composed of allantoin, betaine, propylene glycol, sodium hyaluronate, and D - panthenol in a mass ratio of (0.1 - 0.3):(0.5 - 1.5):(7 - 8):(0.005 - 0.015):(0.1 - 0.3); The preservative is composed of phenoxyethanol and ethylhexylglycerin in a mass ratio of (0.5 - 1.5):1; The skin - brightening and beauty - enhancing composition containing glabrous licorice extract comprises the following components in mass percentages: Angelica sinensis extract 9 - 11%; Dictamnus dasycarpus Turcz. root bark extract 4 - 6%; Glabrous licorice extract 14 - 15%; Gynostemma pentaphyllum extract 9 - 11%; Codonopsis tangshen root extract 0.4 - 0.6%; Rehmannia glutinosa root extract 20 - 22%; Preservative 4 - 6%; The balance is solvent.

2. The moisturizing water of the brightening and beautifying composition containing glabridin extract according to claim 1, characterized in that: The preparation method of the skin - brightening and beauty - enhancing composition containing glabrous licorice extract is as follows: accurately weigh each component raw material, and sequentially add Angelica sinensis extract, Dictamnus dasycarpus Turcz. root bark extract, glabrous licorice extract, Gynostemma pentaphyllum extract, Codonopsis tangshen root extract, Rehmannia glutinosa root extract, preservative, and solvent, and stir evenly to obtain a skin - brightening and beauty - enhancing composition containing glabrous licorice extract.

3. A preparation method of a moisturizing lotion containing a skin brightening and beauty enhancing composition with glabridin extract as described in any one of claims 1-2, characterized in that: Including the following steps: Step 1: Clean and disinfect the equipment and tools required in the preparation method; Step 2: Add the skin - brightening and beauty - enhancing composition containing glabrous licorice extract, solvent, humectant, water - soluble jojoba ester, and EDTA - disodium into a container, raise the temperature to 84 - 86°C, stir evenly at a speed of 200 - 500 r / min, then keep stirring for 9 - 11 min while maintaining the temperature, reduce the speed to 50 - 100 r / min and simultaneously conduct vacuum degassing for 9 - 11 min; Step 3: Then add the preservative into the container, stir and mix evenly to obtain a moisturizing water containing the skin - brightening and beauty - enhancing composition containing glabrous licorice extract.

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