A chenpi decoction for treating heatiness and its preparation method and application

Abstract

The application discloses a Chaiqin Baihu fever-reducing drink and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The application solves the problems that the existing technology mainly adopts symptomatic treatment for treating fever caused by acute upper respiratory tract infection, and the medication is limited due to various factors, and the clinical curative effect is poor. The traditional Chinese medicine composition for preparing the Chaiqin Baihu fever-reducing drink comprises the following traditional Chinese medicine components in parts by mass: 4-8 parts of Radix Bupleuri, 2-4 parts of Radix Scutellariae, 1-3 parts of Notopterygium, 1-3 parts of Radix Puerariae, 8-12 parts of Gypsum Fibrosum, 1-3 parts of Periostracum Cicadae and 1-3 parts of Rhizoma Dioscoreae. The whole prescription combines Ganhan, Kuhang, Xinyin and Xinglei in one pot, and combines cold and warm, clear and transparent, and defense qi, and is suitable for treating the pathogenesis of exogenous fever.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine composition technology, specifically relating to a Chaiqin Baihu antipyretic decoction, its preparation method, and its application. Background Technology

[0002] Acute upper respiratory tract infection is the most common illness, with a high incidence rate. It occurs regardless of the season, but is more prevalent in spring and winter, especially in children. It primarily affects the nose, nasopharynx, and pharynx, hence the common name "URF" (Upper Infection). Complications can involve adjacent organs such as the larynx, trachea, and lungs. It should not be considered a minor ailment.

[0003] Acute upper respiratory tract infections have a high incidence rate, especially in children who are prone to high fever and complications such as pneumonia, seizures, convulsions, collapse, and autism, threatening their lives and health. The cause is mostly viral infection, and Western medicine treatment is mainly symptomatic, with medication use limited by various factors, resulting in unsatisfactory clinical efficacy. Traditional Chinese medicine has accumulated rich experience in treating this disease, and there is currently a clinical need for a safe and highly effective pure Chinese medicine preparation. Summary of the Invention

[0004] In view of the problems that existing technologies for treating acute upper respiratory tract infection fever mainly focus on symptomatic treatment and that the use of drugs is limited by various factors, resulting in poor clinical efficacy, this invention provides a Chaiqin Baihu antipyretic decoction, its preparation method and application.

[0005] The technical solution adopted in this invention is as follows:

[0006] A traditional Chinese medicine composition for preparing Chaiqin Baihu Antipyretic Decoction, comprising the following traditional Chinese medicine components by weight:

[0007] Bupleurum chinense 4-8 parts, Scutellaria baicalensis 2-4 parts, Notopterygium incisum 1-3 parts, Pueraria lobata 1-3 parts, Gypsum 8-12 parts, Cicadae periostracum 1-3 parts, Dioscorea opposita 1-3 parts.

[0008] The mechanism of this formula is as follows: Chaiqin Baihu Antipyretic Drink is a modified version of Xiao Chaihu Decoction, Baihu Decoction, Chaige Jieji Decoction, and Shengjiang Powder. In this formula, kudzu root and notopterygium root dispel cold and relieve muscle tension, dispersing pathogenic factors in the Wei level, embodying the principle of "the body feeling like burning charcoal, which dissipates through sweating." Bupleurum and scutellaria are the main ingredients of Xiao Chaihu Decoction, harmonizing the Shaoyang meridian, reducing fever, and expelling pathogenic factors. Gypsum is the chief ingredient of Baihu Decoction, which originates from the *Shanghan Lun* and has been regarded as a classic formula for relieving fever by traditional Chinese medicine practitioners throughout history. Gypsum is sweet and cold, clearing heat, generating fluids, quenching thirst, and relieving heat in the Yangming meridian. Cicada slough expels pathogenic factors and prevents excessive heat from generating wind. Dioscorea strengthens the spleen, replenishes qi, and nourishes yin, replacing the rice in Baihu Decoction, promoting the dissolution of gypsum in water, and preventing other cold and cooling herbs from damaging the stomach. The entire formula combines sweet and cold, bitter and cold, pungent and warm, and pungent and cool properties, using both cold and warm methods, combining clearing and penetrating, treating both Wei and Qi, and conforming to the pathogenesis of exogenous fever.

[0009] Furthermore, the traditional Chinese medicine composition used to prepare Chaiqin Baihu Antipyretic Decoction includes the following traditional Chinese medicine components by weight: Bupleurum chinense 6 parts, Scutellaria baicalensis 3 parts, Notopterygium incisum 1.5 parts, Pueraria lobata 2 parts, Gypsum 9 parts, Cicadae periostracum 1.5 parts, and Dioscorea opposita 2 parts.

[0010] Furthermore, the traditional Chinese medicine composition used to prepare Chaiqin Baihu Antipyretic Decoction includes the following traditional Chinese medicine components by weight: Bupleurum chinense 6 parts, Scutellaria baicalensis 3 parts, Notopterygium incisum 1.5 parts, Pueraria lobata 2 parts, Gypsum 9 parts, Cicadae periostracum 1.5 parts, and Dioscorea opposita 2 parts.

[0011] After adopting this technical solution, the ratio of Notopterygium root to gypsum is 1:6, and the ratio of Bupleurum root to Scutellaria root is 2:1. This design is because gypsum is pungent and cold in nature, clearing and penetrating, while notopterygium root is both cold and warm in nature, thus relieving fever. In addition, Dioscorea root strengthens the spleen, replenishes qi, and nourishes yin, promoting the dissolution of gypsum in water and preventing other cold medicines from damaging the stomach. Bupleurum root is an excellent antipyretic and needs to be used in large quantities, greater than Scutellaria root. Bupleurum root is an excellent antipyretic in the "Shennong's Classic of Materia Medica," and here it is used for its antipyretic effect, which is actually treating the symptoms, but it needs to be used in large quantities to complement the medicines that treat the root cause, such as clearing internal heat and releasing the exterior. The reason why gypsum is used in greater quantities than gypsum root is because gypsum is heavy and is a mineral, so the amount is generally greater than that of plant-based medicines. Apart from gypsum root, gypsum root is the heaviest.

[0012] A method for preparing a Bupleurum and Scutellaria Decoction for Reducing Fever includes the following steps:

[0013] Step A: Prepare the medicinal materials according to the formula;

[0014] Step B: Mix all the medicinal materials except gypsum evenly, then pulverize the medicinal materials and sieve them to obtain coarse powder;

[0015] Step C: Mix the coarse powder with gypsum according to the ratio to obtain Chaiqin Baihu Antipyretic Drink powder;

[0016] Step D: Soak the powder of Chaiqin Baihu Antipyretic Drink in water to obtain Chaiqin Baihu Antipyretic Drink.

[0017] Furthermore, the sieve used for sieving has a mesh size of 150.

[0018] Application of a Chaiqin Baihu antipyretic decoction in the treatment of exogenous fever.

[0019] As a preferred treatment, Chaiqin Baihu Antipyretic Decoction is used to treat fever caused by acute upper respiratory tract infection.

[0020] This technical approach benefits both adults and children, especially children who are considered to have a pure Yang constitution. When exposed to external pathogens, children are prone to developing heat, sometimes rapidly leading to high fever that doesn't subside. This often results in simultaneous damage to both the Wei Qi and the defensive Qi, causing rapid disease progression and potential transformation into Taiyin, Shaoyin, Jueyin, and other meridian patterns. Therefore, early treatment is crucial to interrupt the heat and prevent further spread. This formula emphasizes treating both the Wei Qi and the defensive Qi, combining clearing and penetrating methods, and primarily using sweet, cold, pungent, and cooling herbs. It avoids excessive use of bitter and cold herbs, which could harm the stomach Qi and the child's vital energy.

[0021] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0022] 1. The Chaiqin Baihu Antipyretic Drink provided by this invention is a modified version of Xiao Chaihu Tang, Baihu Tang, Chaige Jieji Tang, and Shengjiang San. In this formula, Ge Gen and Qianghuo dispel cold and relieve muscle tension, dispelling pathogenic factors in the Wei level, embodying the principle of "the body feeling like burning charcoal, which dissipates through sweating." Chaihu and Huangqin are the main ingredients of Xiao Chaihu Tang, harmonizing Shaoyang, reducing fever, and expelling pathogenic factors. Shigao is the chief ingredient of Baihu Tang, which originates from the *Shanghan Lun* and has been regarded as a classic formula for relieving fever by traditional Chinese medicine practitioners throughout history. Shigao is sweet and cold, clearing heat, generating fluids, quenching thirst, and relieving heat in the Yangming level. Chantui (cicada slough) expels pathogenic factors and prevents excessive heat from generating wind. Shanyao (yam) strengthens the spleen, replenishes qi, and nourishes yin, replacing the rice in Baihu Tang, promoting the dissolution of gypsum in water, and preventing other cold and cooling herbs from damaging the stomach. The entire formula combines sweet and cold, bitter and cold, pungent and warm, and pungent and cool properties, using both cold and warm methods, clearing and penetrating, treating both Wei and Qi, and conforming to the pathogenesis of exogenous fever.

[0023] 2. This invention provides a method for preparing Chaiqin Baihu Antipyretic Drink, which involves pulverizing the medicinal materials into coarse powder and mixing them with gypsum. When using the drink, the powder is soaked in water to obtain Chaiqin Baihu Antipyretic Drink. The method of use is simple. Detailed Implementation

[0024] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions in the embodiments of this application will be clearly and completely described below in conjunction with the embodiments of this application. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments.

[0025] Example 1

[0026] (1) Prepare the raw materials for Chaiqin Baihu Antipyretic Drink

[0027] Each dose of Chaiqin Baihu Antipyretic Drink consists of the following medicinal materials: Bupleurum 6g, Scutellaria baicalensis 3g, Notopterygium incisum 1.5g, Pueraria lobata 2g, Gypsum 9g, Cicadae periostracum 1.5g, and Dioscorea opposita 2g;

[0028] (2) Preparation of Chaiqin Baihu Antipyretic Powder

[0029] Step 1: Mix all the medicinal materials except gypsum (Bupleurum 6g, Scutellaria baicalensis 3g, Notopterygium incisum 1.5g, Pueraria lobata 2g, Cicadae periostracum 1.5g, Dioscorea opposita 2g) evenly;

[0030] Step 2: Crush the mixed medicinal materials to obtain coarse powder;

[0031] Step 3: Divide the coarse powder into two equal portions. Mix each portion with 4.5g of gypsum and then put them into filter paper strips to obtain a dose of Chaiqin Baihu antipyretic powder.

[0032] Step 4: Soak the Chaiqin Baihu Antipyretic Drink powder in water to obtain the Chaiqin Baihu Antipyretic Drink. Each dose of Chaiqin Baihu Antipyretic Drink powder should be taken with 50ml of hot water.

[0033] The clinical data of Chaiqin Baihu Antipyretic Decoction obtained in Example 1 are as follows:

[0034] (I) The clinical data of Chaiqin Baihu Antipyretic Decoction in treating fever caused by acute upper respiratory tract infection in children are as follows:

[0035] 1. Clinical Data

[0036] 1.1 General Information

[0037] A total of 80 patients who met the diagnostic criteria for acute respiratory infection with fever in children were included. They were randomly divided into an experimental group (n=40) and a control group (n=40) using a random sampling method. One patient was dropped out due to transfer to another hospital and was assigned to the control group. A total of 79 cases were completed. The details of the control and experimental groups are shown in Table 1.

[0038] Table 1

[0039] Serial Number Number of examples Male / case Male / case Average age control group 39 20 19 6.5±1.8 experimental group 40 22 18 6.4±1.1

[0040] 1.2 Diagnostic Criteria

[0041] The patient meets the diagnostic criteria for acute upper respiratory tract infection: a history of exposure to cold or contact with infected individuals; predominantly characterized by nasal and pharyngeal catarrhal symptoms such as runny nose, sneezing, nasal congestion, occasional cough, sore throat, hoarseness, and tearing; systemic symptoms may include malaise, chills, fever, headache, dizziness, and aches and pains in the limbs and lower back; physical examination reveals nasal congestion, edema, and discharge; pharyngeal and tonsil congestion and enlargement; blood routine examination shows normal or low white blood cell count, relatively elevated lymphocytes, and normal chest X-ray results. Differential diagnosis criteria: Differential diagnosis criteria for Wei Qi syndrome. Main symptoms: fever, aversion to wind, nasal congestion, thick nasal discharge, sneezing, sore throat, and cough. Accompanying symptoms: sweating or little sweating, thick white or yellow sputum, flushed face, restlessness or irritability, headache, thirst, and dark yellow urine. Tongue, pulse, and fingerprint examination: red tongue with a thin yellow coating, floating and rapid pulse, and floating purple fingerprints. A diagnosis can be made by presenting four primary symptoms plus four secondary symptoms, along with reference to the tongue, pulse, and fingerprints.

[0042] 1.3 Inclusion Criteria

[0043] The patient meets the diagnostic criteria for acute upper respiratory tract infection; blood routine tests exclude bacterial infection; meets the syndrome differentiation criteria for Wei Qi syndrome; is aged 1-14 years, regardless of gender; has an axillary temperature ≥38.5℃; and has been approved by the hospital's ethics committee and the child's parents have signed an informed consent form.

[0044] 1.4 Exclusion Criteria

[0045] Children with abnormal chest X-ray findings; those with pharyngitis-conjunctivitis, herpetic pharyngitis, EB virus infection, or severe respiratory infectious diseases; those with lower respiratory tract infections or severe malnutrition; those with severe systemic diseases of the heart, lungs, liver, kidneys, and blood system, or those with epilepsy or mental illness.

[0046] 2. Method

[0047] 2.1 Treatment methods

[0048] The control group received ibuprofen tablets plus a placebo (a powder in a food-grade pouch without any drug ingredients; the packaging and soaking solution were the same color as the Chaiqin Baihu Antipyretic Drink), while the experimental group received the Chaiqin Baihu Antipyretic Drink from Example 1. Both groups underwent a 3-day treatment course. Axillary temperatures were recorded before medication and at 30 minutes, 1 hour, 2 hours, 3 hours, and 4 hours after the first dose. The antipyretic efficacy rate was calculated. The onset time of antipyretic effect was recorded (onset time: from the start of medication administration until the child's temperature first returned to normal). Temperature recurrence was recorded (from the start of medication administration until the temperature returned to normal and did not rise again, counting the total number of fever episodes). The antipyretic rate (axillary temperature dropping below 37.2℃ within those days and not rising again) was calculated on days 1, 2, and 3 of treatment.

[0049] 2.2 Criteria for Judging Therapeutic Effect

[0050] According to the overall efficacy evaluation criteria in the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines":

[0051] ① Clinical recovery: Body temperature returns to normal (axillary temperature below 37.2℃ and does not rise again within 24-48 hours of taking medication, the same below), clinical symptoms and signs disappear, abnormal physical and chemical indicators return to normal, and the score value decreases by ≥95%.

[0052] ②The body temperature returns to normal within 24-48 hours after taking the medication, and the scores of the main clinical symptoms and signs decrease by ≥70%.

[0053] ③ The body temperature returns to normal within 48-72 hours after effective medication, and the scores of the main clinical symptoms and signs decrease by ≥30%.

[0054] ④ For those who fail to meet the above standards, their points will be reduced by less than 30%.

[0055] Overall effective rate = (number of cured cases + number of cases with significant improvement + number of cases with improvement) ÷ total number of cases × 100%;

[0056] 3. Treatment Results

[0057] The clinical efficacy of the experimental group and the control group is shown in Table 1; the antipyretic efficacy of the experimental group and the control group is shown in Table 2; the number of recurrent fevers and the antipyretic rates at 1 day, 2 days and 3 days are shown in Table 3.

[0058] Group Total number of cases get well Effective efficient invalid Overall efficiency control group 39 5(12.8％) 18(46.2％) 12(30.7％) 4(10.3％) 89.7％ experimental group 40 12(30％) 21(52.5％) 6(15％) 1(2.5％) 97.5％

[0059] The results in Table 1 show that the experimental group had significantly better therapeutic effects on fever reduction and acute upper respiratory tract infection in children than the control group, and the total effective rate was higher than that of the control group.

[0060] Table 2 ( ℃)

[0061]

[0062] Note: Compared with the control group at the same time point, p < 0.05;

[0063] The results in Table 2 show that the fever reduction rate in the experimental group was significantly faster than that in the control group.

[0064] Table 3

[0065]

[0066] Note: Compared with the control group at the same time point, p < 0.05;

[0067] The results in Table 3 show that the experimental group had significantly fewer recurrent fevers than the control group, and the fever subsided faster.

[0068] As can be seen from the above, this Chaiqin Baihu Antipyretic Drink can be used to treat fever caused by acute upper respiratory tract infection in children, and its efficacy is superior to that of ibuprofen.

[0069] 4. Typical Cases

[0070] 1. Jiang, male, 6 years old, presented with a 3-day history of fever. Physical examination revealed a temperature of 38.3℃, pharyngeal congestion, enlarged tonsils, coarse breath sounds in both lungs with no obvious dry or wet rales, and normal blood routine tests. The diagnosis was acute upper respiratory tract infection. He was prescribed one dose of Chaiqin Baihu Antipyretic Decoction three times daily. After one day, his temperature returned to normal, and all symptoms subsided.

[0071] 2. Xie, male, 3 years old, presented with "fever and sore throat for 1 day". Physical examination: T 38.5℃, pharyngeal congestion, tonsils not enlarged, coarse breath sounds in both lungs, no obvious dry or wet rales, blood routine showed neutrophil ratio of 55%, other abnormalities were not found. The diagnosis was: acute upper respiratory tract infection. He was given 2 bags of Chaiqin Baihu antipyretic decoction, 3 times a day. After 1 day, his body temperature returned to normal and all symptoms were relieved.

[0072] 3. Wang, male, 2 years old, presented with a 1-day history of fever. Physical examination revealed a temperature of 38.9℃, pharyngeal congestion, enlarged tonsils, coarse breath sounds in both lungs with no obvious dry or wet rales, and normal blood routine tests. The diagnosis was acute upper respiratory tract infection. He was prescribed one dose of Chaiqin Baihu Antipyretic Decoction twice daily. After one day, his temperature returned to normal, and all symptoms subsided.

[0073] 4. Ms. Chen, 11 years old, presented with a one-day history of fever. Physical examination revealed a temperature of 39.9°C, pharyngeal congestion, enlarged tonsils, coarse breath sounds in both lungs with no obvious dry or wet rales, and a normal blood count. The diagnosis was acute upper respiratory tract infection. She was prescribed one dose of Chaiqin Baihu Antipyretic Decoction three times daily. After 0.5 days, her temperature returned to normal, and all symptoms subsided.

[0074] 5. Luo, male, 13 years old, presented with a 2-day history of fever. Physical examination revealed a temperature of 39.8℃, pharyngeal congestion, enlarged tonsils, coarse breath sounds in both lungs with no obvious dry or wet rales, and normal blood routine tests. The diagnosis was acute upper respiratory tract infection. He was prescribed one dose of Chaiqin Baihu Antipyretic Decoction three times daily. After one day, his temperature returned to normal, and his symptoms subsided.

[0075] 6. Ms. Chen, female, 4 years old, presented with a fever lasting 0.5 days. Physical examination revealed a temperature of 39.1℃, pharyngeal congestion, enlarged tonsils, coarse breath sounds in both lungs with no obvious dry or wet rales, and normal blood routine tests. The diagnosis was acute upper respiratory tract infection. She was given one dose of Chaiqin Baihu Antipyretic Decoction twice daily. After one day, her temperature returned to normal, and all symptoms subsided.

[0076] 7. Ni, male, 7 years old, presented with a 3-day history of fever. Physical examination revealed a temperature of 38.8℃, pharyngeal congestion, enlarged tonsils, coarse breath sounds in both lungs with no obvious dry or wet rales, and normal blood routine tests. The diagnosis was acute upper respiratory tract infection. He was prescribed one dose of Chaiqin Baihu Antipyretic Decoction three times daily. After one day, his temperature returned to normal, and all symptoms subsided.

[0077] (II) The clinical data of Chaiqin Baihu Antipyretic Decoction in treating exogenous fever caused by other reasons in adults or children are as follows:

[0078] Typical examples are as follows:

[0079] 1. Ms. Huang, 60 years old, presented with a 2-day history of fever and cough. Physical examination revealed a temperature of 38.5℃, pharyngeal congestion, enlarged tonsils, coarse breath sounds in both lungs with minimal dry or wet rales, and a blood test showing a lymphocyte percentage of 77%, with no other abnormalities. She was diagnosed with acute bronchitis and prescribed two packets of Chaiqin Baihu Antipyretic Decoction three times daily. Her temperature returned to normal after one and a half days. She was then given cough suppressants and expectorants, and her cough subsided after three days, with no further recurrence of fever.

[0080] 2. Ms. Zhang, 40 years old, presented with "fever, sore throat, and fatigue for 3 days". Physical examination revealed: temperature 38.2℃, pharyngeal congestion, tonsils not enlarged, clear breath sounds in both lungs, no obvious dry or wet rales, blood routine test showed a lymphocyte ratio of 78%, and no other abnormalities. The influenza A test was positive, and the diagnosis was: influenza A. She was prescribed 2 packets of Chaiqin Baihu Antipyretic Decoction, 3 times a day. After 2 days, her body temperature returned to normal, and her fatigue and sore throat were relieved.

[0081] 3. Mr. Fang, male, 50 years old, presented with a 3-day history of fever and cough. Physical examination revealed a temperature of 38.4℃, pharyngeal congestion, enlarged tonsils, coarse breath sounds in both lungs, and indistinct dry and wet rales. Blood tests showed a white blood cell count of 10.2*10^9 / L, a neutrophil ratio of 77%, and no other abnormalities. Mycoplasma titer was 1:320. Chest CT scan was normal. The diagnosis was acute mycoplasma infection. He was prescribed two packets of Chaiqin Baihu antipyretic decoction three times daily, along with azithromycin dispersible tablets for anti-infection treatment. His temperature returned to normal after one and a half days, and his cough subsided after three days, with no further recurrence of fever.

[0082] 4. Mr. Liu, male, 47 years old, presented with "fever, sore throat, and fatigue for 2 days". Physical examination: T 39℃, pharyngeal congestion, tonsils not enlarged, clear breath sounds in both lungs, no obvious dry or wet rales, blood routine showed lymphocyte ratio of 80%, other abnormalities were not found, influenza B test was positive, diagnosed as: influenza B, prescribed 2 bags of Chaiqin Baihu antipyretic decoction, 3 times a day, after 2 days the body temperature returned to normal, and fatigue and sore throat were relieved.

[0083] 5. Ms. Zhao, 66 years old, presented with a history of "recurrent cough with phlegm and shortness of breath for over 10 years, and fever and sore throat for 1 day." Physical examination revealed a temperature of 38.4℃, pharyngeal congestion, enlarged tonsils, barrel chest, coarse breath sounds in both lungs with minimal dry and wet rales, and a blood test showing a neutrophil percentage of 55%, with no other abnormalities. Chest CT scan showed localized pulmonary fibrosis and scattered inflammatory changes. The diagnosis was: 1. Acute upper respiratory tract infection; 2. Chronic obstructive pulmonary disease in remission. She was prescribed two packets of Chaiqin Baihu Antipyretic Decoction three times daily. After one day, her temperature dropped to 37.5℃, and after two days, her temperature returned to normal, and all symptoms subsided.

[0084] 6. Mr. Li, male, 28 years old, presented with "fever and sore throat for 2 days". Physical examination: T 39.2℃, pharyngeal congestion, tonsils not enlarged, coarse breath sounds in both lungs, no obvious dry or wet rales, blood routine showed neutrophil ratio of 57%, other abnormalities were not found. Diagnosed as: acute upper respiratory tract infection. He was prescribed 2 bags of Chaiqin Baihu Antipyretic Decoction, 3 times a day. After 1 day, his body temperature returned to normal and all symptoms were relieved.

[0085] 8. Ms. Jiang, 27 years old, presented with "fever, sore throat, and fatigue for 3 days". Physical examination: T 39℃, pharyngeal congestion, tonsils not enlarged, clear breath sounds in both lungs, no obvious dry or wet rales, blood routine showed lymphocyte ratio of 76%, other abnormalities were not found, influenza B test was positive, diagnosed as: influenza B, prescribed 2 bags of Chaiqin Baihu antipyretic decoction, 3 times a day, after 2 days the body temperature returned to normal, and the fatigue and sore throat were relieved.

[0086] 9. Ms. Zhang, 40 years old, presented with a 3-day history of fever and sore throat. Physical examination revealed a temperature of 38.6℃, pharyngeal congestion, grade II tonsillar enlargement with a few purulent spots, clear breath sounds in both lungs, and no obvious dry or wet rales. Blood tests showed a neutrophil count of 85%, with no other abnormalities. The diagnosis was acute suppurative tonsillitis. She was prescribed two packets of Chaiqin Baihu Antipyretic Decoction three times daily, along with oral cephalosporin antibiotics. Her temperature returned to normal after two days, and her sore throat subsided after five days. No abnormalities were found in her tonsils.

[0087] 10. Ms. Lu, female, 49 years old, presented with a 7-day history of cough, with symptoms lasting 2 days. Physical examination revealed a temperature of 38.7℃, no pharyngeal congestion, enlarged tonsils, coarse breath sounds in both lungs, and a few moist rales in the right lower lung. Blood tests showed a white blood cell count of 13.2*10^9 / L, a neutrophil ratio of 88%, and no other abnormalities. Chest CT showed right lower lung pneumonia. The diagnosis was right lower lung pneumonia. She was prescribed two packets of Chaiqin Baihu Antipyretic Decoction three times daily, combined with intravenous cephalosporin antibiotics. Her temperature returned to normal after three days, and her cough subsided after one week. Follow-up chest CT and blood tests showed no abnormalities.

[0088] The embodiments described above merely illustrate specific implementation methods of this application, and while the descriptions are detailed, they should not be construed as limiting the scope of protection of this application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the technical solution of this application, and these modifications and improvements all fall within the scope of protection of this application.

Claims

1. A Chaiqin Baihu fever-reducing drink, characterized in that: This medicine, used to treat fever caused by external pathogens in children, is prepared by the following Chinese herbal components in grams: Bupleurum chinense 6g, Scutellaria baicalensis 3g, Notopterygium incisum 1.5g, Pueraria lobata 2g, Gypsum 9g, Cicadae periostracum 1.5g, and Dioscorea opposita 2g.

2. A method for preparing a Chaiqin Baihu antipyretic drink, characterized in that: Includes the following steps: Step A: Prepare the medicinal materials according to the formula of claim 1; Step B: Mix all the medicinal materials except gypsum evenly, then pulverize the medicinal materials and sieve them to obtain coarse powder; Step C: Mix the coarse powder with gypsum according to the ratio to obtain Chaiqin Baihu Antipyretic Drink powder; Step D: Soak the powder of Chaiqin Baihu Antipyretic Drink in water to obtain Chaiqin Baihu Antipyretic Drink.

3. The preparation method of the Chaiqin Baihu antipyretic drink according to claim 2, characterized in that: The sieve used for sieving has a mesh size of 150.

4. The application of the Chaiqin Baihu antipyretic decoction as described in claim 1 in the preparation of a medicine for treating exogenous fever in children.

5. The application according to claim 4, characterized in that: Application of Chaiqin Baihu Antipyretic Decoction in the preparation of drugs for treating fever caused by acute upper respiratory tract infection.

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