A compound hemorrhoid essential oil and a preparation method thereof

Abstract

The present application relates to the technical field of biological medicine, and discloses a compound essential oil for hemorrhoids and a preparation method thereof.The compound essential oil for hemorrhoids comprises essential oil of Xuchangqing, essential oil of Daji, essential oil of Danggui, essential oil of bitter almond, essential oil of Jiangxiang, essential oil of Muxie, essential oil of Fangfeng, grape seed oil and coconut oil; and the synergistic effect among the components is achieved through the proportioning of the components, the blood circulation of the perianal and hemorrhoid veins can be prevented and changed, the excessive varicosity and filling of the anus can be eliminated, internal hemorrhoids, external hemorrhoids and mixed hemorrhoids can be treated, the local repair after operation can be used, inflammation and pain can be eliminated, the anus itching, sinking and swelling discomfort can be improved, heat can be cleared, blood can be cooled and swelling can be eliminated, the pain caused by hemorrhoids can be improved, the symptoms of hemorrhoids can be alleviated, and the self-repairing ability of the body can be improved.

Description

Technical Field

[0001] This invention belongs to the field of biomedical technology, and in particular relates to a compound essential oil for hemorrhoids and its preparation method. Background Technology

[0002] Anal diseases are common and seriously affect patients' quality of life. Hemorrhoid patients, whose main symptom is rectal bleeding, often develop anemia. If left untreated, they may experience paleness, weakness, and dizziness; standing up suddenly after prolonged sitting or squatting can lead to collapse or fainting. It can also cause skin eczema, as the prolapsed hemorrhoids and mucus discharge irritate the skin, causing itching and anal eczema. Furthermore, it can lead to rectal deterioration; if left untreated, the lesions worsen, causing cell damage and rectal complications. In women, hemorrhoids can cause gynecological inflammation. Bleeding and inflammation can lead to the proliferation of fungi, causing various types of vaginitis, urethritis, cystitis, and even adnexitis.

[0003] Essential oils are volatile aromatic substances extracted from the flowers, stems, leaves, roots, or fruits of plants through steam distillation, expression, cold maceration, or solvent extraction. Domestic research and applications have confirmed that essential oils can prevent infectious diseases, combat bacteria, viruses, and fungi, prevent inflammation and spasms, promote cell metabolism and regeneration, and enhance the body's disease resistance.

[0004] Essential oils are concentrated small molecules. Their molecules are smaller than human pores, allowing them to easily penetrate the pores and then be absorbed into the bloodstream through capillaries. They are also easily absorbed and metabolized by the body. Essential oils extracted from plants are also known as plant hormones, as they are very similar to human hormones, making them suitable for daily health maintenance and enhancing the body's immunity.

[0005] Although there are many hemorrhoid products available, the side effects of Western medicine and its poor transdermal absorption, which makes it easy for the medication to stick to underwear and cause many problems in daily life, are among the reasons why users give up on it. Summary of the Invention

[0006] The purpose of this invention is to provide a compound essential oil for hemorrhoids, which can relieve and / or block hemorrhoid symptoms and reduce the suffering of hemorrhoid patients.

[0007] This invention provides a compound essential oil for hemorrhoids, comprising: Cynanchum paniculatum essential oil, Cirsium japonicum essential oil, Angelica sinensis essential oil, bitter almond essential oil, Dalbergia odorifera essential oil, nutmeg essential oil, Saposhnikovia divaricata essential oil, grapeseed oil, and coconut oil.

[0008] Furthermore, the following ingredients are used: 0.5-2 parts of Cynanchum paniculatum oil, 0.5-2 parts of Cirsium japonicum oil, 0.5-3.5 parts of Angelica sinensis oil, 0.1-1.5 parts of bitter almond oil, 0.1-1.5 parts of Dalbergia odorifera oil, 0.1-1.5 parts of nutmeg oil, 0.1-1.5 parts of Saposhnikovia divaricata oil, 45-55 parts of grapeseed oil, and 35-45 parts of coconut oil.

[0009] In some specific embodiments of the present invention, the hemorrhoid compound essential oil, by volume, comprises: 1-1.5 parts of Cynanchum paniculatum essential oil, 1-1.5 parts of Cirsium japonicum essential oil, 1-3 parts of Angelica sinensis essential oil, 0.4-1 part of bitter almond essential oil, 0.4-1 part of Dalbergia odorifera essential oil, 0.3-1 part of nutmeg essential oil, 0.3-1 part of Saposhnikovia divaricata essential oil, 50 parts of grapeseed oil, and 40 parts of coconut oil.

[0010] In some specific embodiments of the present invention, the hemorrhoid compound essential oil, by volume, comprises: 1 part of Cynanchum paniculatum essential oil, 1 part of Cirsium japonicum essential oil, 1 part of Angelica sinensis essential oil, 0.5 parts of bitter almond essential oil, 0.5 parts of Dalbergia odorifera essential oil, 0.5 parts of nutmeg essential oil, 0.5 parts of Saposhnikovia divaricata essential oil, 50 parts of grapeseed oil, and 40 parts of coconut oil.

[0011] In some specific embodiments of the present invention, the hemorrhoid compound essential oil, by volume, comprises: 1.2 parts of Cynanchum paniculatum essential oil, 1.2 parts of Cirsium japonicum essential oil, 1.2 parts of Angelica sinensis essential oil, 0.4 parts of bitter almond essential oil, 0.4 parts of Dalbergia odorifera essential oil, 0.3 parts of nutmeg essential oil, 0.3 parts of Saposhnikovia divaricata essential oil, 50 parts of grapeseed oil, and 45 parts of coconut oil.

[0012] In some specific embodiments of the present invention, the hemorrhoid compound essential oil, by volume, comprises: 1.5 parts of Cynanchum paniculatum essential oil, 1.5 parts of Cirsium japonicum essential oil, 3 parts of Angelica sinensis essential oil, 1 part of bitter almond essential oil, 1 part of Dalbergia odorifera essential oil, 1 part of nutmeg essential oil, 1 part of Saposhnikovia divaricata essential oil, 50 parts of grapeseed oil, and 40 parts of coconut oil.

[0013] This invention also provides a method for preparing a compound essential oil for hemorrhoids, comprising the following steps:

[0014] (1) Mix the essential oils of Cynanchum paniculatum, Cirsium japonicum, Angelica sinensis, bitter almond, Dalbergia odorifera, nutmeg, and Saposhnikovia divaricata to obtain mixed essential oil A;

[0015] (2) Extract the mixed essential oil A to obtain mixed essential oil B;

[0016] (3) Mix the blended essential oil B with grape seed oil and coconut oil to obtain the hemorrhoid compound essential oil.

[0017] In this invention, the extraction method can be selected from liquid-liquid extraction, aqueous two-phase extraction, supercritical extraction, reverse micelle extraction, single-stage extraction, continuous extraction, countercurrent extraction, and differential extraction; preferably, supercritical extraction.

[0018] Furthermore, in step (3), after mixing, the mixture is sealed and left to stand at 5-30°C for at least 10 hours.

[0019] Furthermore, in step (3), grapeseed oil and coconut oil are mixed and stored for 60 minutes before the mixed essential oils are added.

[0020] When a quality ratio or other value or parameter is expressed as a range, a preferred range, or a range defined by a series of upper and lower preferred values, this should be understood as specifically disclosing all ranges formed by any pair of any upper or preferred value with any lower or preferred value, regardless of whether the range is disclosed individually. For example, when the range “1 to 5” is disclosed, the described range should be interpreted as including the ranges “1 to 4”, “1 to 3”, “1 to 2”, “1 to 2 and 4 to 5”, “1 to 3 and 5”, etc. When numerical ranges are described herein, unless otherwise stated, the range is intended to include its endpoints and all integers and fractions within that range.

[0021] The approximate terms used in the specification and claims to modify quantities indicate that the invention is not limited to that specific quantity, but also includes acceptable modifications close to that quantity that do not alter the relevant essential function. In this specification and claims, scope definitions may be combined and / or interchanged, unless otherwise stated, these scopes include all sub-scopes contained therein.

[0022] The beneficial effects of this invention are at least as follows:

[0023] (1) This invention provides a compound essential oil composed of Cynanchum paniculatum essential oil, Cirsium japonicum essential oil, Angelica sinensis essential oil, bitter almond essential oil, Dalbergia odorifera essential oil, nutmeg essential oil, Saposhnikovia divaricata essential oil, grapeseed oil, and coconut oil. This compound essential oil achieves synergistic effects among its components through the proportion of each component. It can prevent and change the venous blood circulation in the perianal area and hemorrhoids; eliminate excessive varicose veins and congestion in the anus; treat internal hemorrhoids, external hemorrhoids, and mixed hemorrhoids; and can also be used for postoperative local repair, anti-inflammatory and analgesic effects; improve anal itching, distension and discomfort, clear heat, cool blood and reduce swelling; improve pain caused by hemorrhoids, alleviate hemorrhoid symptoms, and enhance the body's self-repair ability.

[0024] (2) Compared to Ma Yinglong Hemorrhoid Ointment, which is used externally, pregnant women should use it with caution or as directed by a doctor, and it is contraindicated for those allergic to this product and those with allergic constitutions. In contrast, the compound essential oil of this invention uses natural substances, "essential oils" and "base oils," extracted entirely from aromatic plants and medicinal herbs. It effectively utilizes plant essences and, through compounding, forms a compound essential oil that is suitable for all ages, safe, pure, and effective. Attached Figure Description

[0025] Figure 1 The images show the results of treatment for each group.

[0026] Figure 2 Changes in inflammatory factors in the anal sphincter group;

[0027] Figure 3 The changes in the levels of the inflammatory cytokine IL-1β after treatment in each group;

[0028] Figure 4 The changes in the levels of the inflammatory factor IL-6 after treatment in each group;

[0029] Figure 5 The changes in the levels of the inflammatory factor TNF-α after treatment in each group;

[0030] Figure 6 HE staining image of the anal tract;

[0031] Figure 7 HE staining images of each group after treatment. Detailed Implementation

[0032] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0033] Example 1

[0034] A compound essential oil for hemorrhoids contains: 1 part of Cynanchum paniculatum essential oil, 1 part of Cirsium japonicum essential oil, 1 part of Angelica sinensis essential oil, 0.5 part of bitter almond essential oil, 0.5 part of Dalbergia odorifera essential oil, 0.5 part of nutmeg essential oil, 0.5 part of Saposhnikovia divaricata essential oil, 50 parts of grapeseed oil, and 45 parts of coconut oil. This formula is labeled "Anhao" (meaning "Good for Anus").

[0035] Preparation method:

[0036] Mix the essential oils of Cynanchum paniculatum, Cirsium japonicum, Angelica sinensis, bitter almond, Dalbergia odorifera, nutmeg, and Saposhnikovia divaricata in a clean aluminum or glass container according to the specified proportions to form a "compound pure essential oil". Then, use "supercritical extraction" to extract the chemical components that are not beneficial to the human body from the compound pure essential oil, making the molecules of the fully blended Chinese herbal essential oils and aromatic plant essential oils more uniform, and ensuring that their physical, chemical, and pharmacological properties meet the requirements of safety, purity, and effectiveness. Mix grape seed oil and coconut oil in a clean container and let it stand for at least 60 minutes. Add the seven blended essential oils obtained through supercritical extraction to the two blended base oils and stir for 10 minutes. Roll the mixture clockwise at 10 degrees Celsius for 8 hours, then seal it at -5 degrees Celsius for 10 hours, and finally seal it at 5-30 degrees Celsius for 10 hours to allow the fully blended essential oils and base oils to blend again, resulting in a more natural aroma.

[0037] Example 2

[0038] A compound essential oil for hemorrhoids contains: 1.2 parts of Cynanchum paniculatum essential oil, 1.2 parts of Cirsium japonicum essential oil, 1.2 parts of Angelica sinensis essential oil, 0.4 parts of bitter almond essential oil, 0.4 parts of Dalbergia odorifera essential oil, 0.3 parts of nutmeg essential oil, 0.3 parts of Saposhnikovia divaricata essential oil, 50 parts of grapeseed oil, and 45 parts of coconut oil. This formula is designated as "Formula L".

[0039] The preparation method is the same as in Example 1.

[0040] Example 3

[0041] A compound essential oil for hemorrhoids contains: 1.5 parts of Cynanchum paniculatum essential oil, 1.5 parts of Cirsium japonicum essential oil, 3 parts of Angelica sinensis essential oil, 1 part of bitter almond essential oil, 1 part of Dalbergia odorifera essential oil, 1 part of nutmeg essential oil, 1 part of Saposhnikovia divaricata essential oil, 50 parts of grapeseed oil, and 40 parts of coconut oil.

[0042] The preparation method is the same as in Example 1.

[0043] Experimental Example 1

[0044] 1. Model Establishment

[0045] In the model group, 10 mL of croton oil was mixed with 90 mL of anhydrous ether. After thorough mixing, a cotton swab was used to apply the mixture to the rat's anus, approximately 20 mm deep, and held for 30 seconds while simultaneously rotating it slowly 5 times to establish a rat anal croton oil swelling model. Physiological saline was used as a blank control. The modeling effect was checked after 6 hours, and the anal condition of the normal group and the model group was observed and recorded.

[0046] 2. Test methods

[0047] Using a rat model of anal inflammation, the compound essential oil of this invention was applied topically for treatment for 7 consecutive days, 3 times a day.

[0048] ① Control group (6 animals): treated with physiological saline for 7 consecutive days, 3 times a day;

[0049] ② Model group (6 animals): treated with physiological saline for 7 consecutive days, 3 times a day;

[0050] ③ Anhao Group (6 animals): Anhao essential oil was administered for 7 consecutive days, 3 times a day;

[0051] ④ Formula L group (6 animals): Administer the medication continuously for 7 days, 3 times a day (applied topically);

[0052] ⑤ Formula S group (6 animals): Administer the drug continuously for 7 days, 3 times a day (applied topically);

[0053] ⑥ Ma Yinglong Musk Hemorrhoid Ointment Group (6 cases): Administered clinical medication Ma Yinglong Musk Hemorrhoid Ointment (1g / kg).

[0054] After 7 days of continuous administration of the drug (applied topically) three times a day, the rats were sacrificed, photographed, and their anal tissue was extracted to observe pathological changes and expression of inflammatory factors in the anal tissue.

[0055] 3. Results Analysis

[0056] (1) Improvement of anal condition

[0057] like Figure 1 As shown, rats in the model group, Anhao group, Formula L group, Formula S group, and Ma Yinglong Musk Hemorrhoid Ointment group exhibited significant anal swelling, confirming successful model establishment. Among these, the degree of swelling significantly decreased in the Anhao group, Formula L group, Formula S group, and the hemorrhoid ointment group after drug treatment.

[0058] (2) Changes in inflammatory factors

[0059] like Figure 2 As shown, the serum levels of TNF-α, IL-6, and IL-1β were significantly elevated in rats with anal swelling, and treatment with Anhao essential oil could reduce the levels of these inflammatory factors.

[0060] like Figures 3-5 As shown, there were no significant differences in the serum levels of TNF-α, IL-6, and IL-1β in the four groups of rats with anal swelling after administration, indicating that the three formulations did not differ significantly from the therapeutic effects of Mayinglong Musk Hemorrhoid Ointment.

[0061] (3) HE staining to observe pathological changes in anal tissue

[0062] like Figure 6As shown: Anhao essential oil has a good therapeutic effect on anal swelling; under microscopic examination of the anal tissue of rats in the control group, the mucosal epithelial tissue was intact and the structure was normal; in the model group, the anal mucosal epithelial tissue of rats showed necrosis, obvious inflammatory cell infiltration, submucosal edema, and mucosal bleeding; in the Anhao group, anal injury was significantly improved, submucosal edema was reduced, mucosal bleeding was reduced, the boundary was clearer, and inflammatory cell infiltration was reduced.

[0063] like Figure 7 As shown: In the "Anhao" group, anal injury was significantly improved, submucosal edema was reduced, mucosal bleeding was reduced, the borders were clearer, and inflammatory cell infiltration was reduced. In the "Formula L" group, the anal mucosal epithelial tissue of rats showed necrosis, significant inflammatory cell infiltration, submucosal edema, and mucosal bleeding, with a weaker improvement effect. In the "Formula S" group, anal injury was significantly improved, submucosal edema was reduced, mucosal bleeding was reduced, and inflammatory cell infiltration was reduced, but the degree of inflammatory cell infiltration was higher than in the "Anhao" group but significantly lower than in the "Formula L" group, indicating that the improvement effect of "Formula S" was slightly weaker than "Anhao" but significantly stronger than that of "Formula L". In the "Ma Yinglong Musk Hemorrhoid Ointment" group, submucosal edema was reduced, mucosal bleeding was reduced, the borders were clearer, and inflammatory cell infiltration was reduced, with the degree of inflammatory infiltration being weaker than in the "Anhao" group.

[0064] Although Ma Yinglong hemorrhoid ointment is widely used clinically, its instructions emphasize that it is for external use only and should be used with caution by pregnant women or as directed by a physician. It is contraindicated for those allergic to the product, and should be used with caution by those with allergic constitutions. In contrast, the hemorrhoid compound essential oil of this invention is made entirely from natural substances extracted from aromatic plants and medicinal herbs—"essential oils" and "base oils"—which are then blended to form a compound essential oil suitable for all ages, safe, pure, and effective.

[0065] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A compound essential oil for hemorrhoids, characterized in that, By volume, it is made from: 0.5-2 parts of Cynanchum paniculatum essential oil, 0.5-2 parts of Cirsium japonicum essential oil, 0.5-3.5 parts of Angelica sinensis essential oil, 0.1-1.5 parts of bitter almond essential oil, 0.1-1.5 parts of Dalbergia odorifera essential oil, 0.1-1.5 parts of nutmeg essential oil, 0.1-1.5 parts of Saposhnikovia divaricata essential oil, 45-55 parts of grapeseed oil, and 35-45 parts of coconut oil.

2. The hemorrhoid compound essential oil according to claim 1, characterized in that, By volume, it is made from: 1-1.5 parts of Cynanchum paniculatum essential oil, 1-1.5 parts of Cirsium japonicum essential oil, 1-3 parts of Angelica sinensis essential oil, 0.4-1 part of bitter almond essential oil, 0.4-1 part of Dalbergia odorifera essential oil, 0.3-1 part of nutmeg essential oil, 0.3-1 part of Saposhnikovia divaricata essential oil, 50 parts of grapeseed oil, and 40 parts of coconut oil.

3. The hemorrhoid compound essential oil according to claim 1, characterized in that, By volume, it is made from: 1 part of Cynanchum paniculatum essential oil, 1 part of Cirsium japonicum essential oil, 1 part of Angelica sinensis essential oil, 0.5 part of bitter almond essential oil, 0.5 part of Dalbergia odorifera essential oil, 0.5 part of nutmeg essential oil, 0.5 part of Saposhnikovia divaricata essential oil, 50 parts of grapeseed oil, and 40 parts of coconut oil.

4. The hemorrhoid compound essential oil according to claim 1, characterized in that, By volume, it is made from: 1.2 parts of Cynanchum paniculatum essential oil, 1.2 parts of Cirsium japonicum essential oil, 1.2 parts of Angelica sinensis essential oil, 0.4 parts of bitter almond essential oil, 0.4 parts of Dalbergia odorifera essential oil, 0.3 parts of nutmeg essential oil, 0.3 parts of Saposhnikovia divaricata essential oil, 50 parts of grapeseed oil, and 45 parts of coconut oil.

5. The hemorrhoid compound essential oil according to claim 1, characterized in that, By volume, it is made from: 1.5 parts of Cynanchum paniculatum essential oil, 1.5 parts of Cirsium japonicum essential oil, 3 parts of Angelica sinensis essential oil, 1 part of bitter almond essential oil, 1 part of Dalbergia odorifera essential oil, 1 part of nutmeg essential oil, 1 part of Saposhnikovia divaricata essential oil, 50 parts of grapeseed oil, and 40 parts of coconut oil.

6. The method for preparing the hemorrhoid compound essential oil according to any one of claims 1 to 5, characterized in that, Includes the following steps: (1) Mix the essential oils of Cynanchum paniculatum, Cirsium japonicum, Angelica sinensis, bitter almond, Dalbergia odorifera, nutmeg, and Saposhnikovia divaricata to obtain mixed essential oil A; (2) Extract the mixed essential oil A to obtain mixed essential oil B; (3) Mix the blended essential oil B with grape seed oil and coconut oil to obtain the hemorrhoid compound essential oil.

7. The preparation method according to claim 6, characterized in that, The extraction method is supercritical extraction.

8. The preparation method according to claim 6, characterized in that, In step (3), after mixing, the mixture is sealed and left to stand at 5-30°C for at least 10 hours.

9. The preparation method according to claim 6, characterized in that, In step (3), grape seed oil and coconut oil are mixed and left to stand for 60-80 minutes before the mixed essential oils are added.

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