Conveyor device and medical system

Abstract

An embodiment of the present invention discloses a delivery device for a prosthesis, comprising a moving assembly, an intermediate wire, a stroke positioning member and a housing; the housing includes an inner cavity; the moving assembly includes a moving member, the distal end of the moving member is disposed in the inner cavity of the housing, the moving member is movable relative to the housing along the axial direction of the housing, and the moving member is configured to drive the prosthesis to move by driving the axial movement of the intermediate wire; the stroke positioning member is movably passed through the housing to extend into the inner cavity; the stroke positioning member is configured to abut against the moving member to prevent the moving member from continuing to move when the moving member moves to a preset position and the prosthesis moves to a first position; when the moving member moves to the preset position and the prosthesis does not move to the first position, the stroke positioning member is removed or at least partially moved to avoid the moving member, so that the moving member can continue to move, and further the prosthesis moves to the first position. The present invention also discloses a medical system.

Description

Technical Field

[0001] Embodiments of the present invention relate to the technical field of medical devices, and in particular to a delivery device and a medical system. Background Art

[0002] The mitral valve is composed of two valve leaflets attached to the periphery of the left atrioventricular orifice, which can prevent the blood in the left ventricle from flowing back into the left atrium. Organic or functional changes in the mitral valve and its related structures will lead to poor anastomosis of the anterior and posterior leaflets of the mitral valve, resulting in blood reflux from the left ventricle to the left atrium. When the heart contracts, the left atrium simultaneously receives the blood refluxed from the left ventricle and the blood input from the pulmonary veins. The blood volume in the left atrium increases significantly and the pressure rises, leading to left atrial hypertrophy. When the heart relaxes, more blood flows from the left atrium to the left ventricle, causing the left ventricle to hypertrophy due to enhanced contraction. After evolving from the compensatory stage to the decompensated stage, heart failure occurs in both the left atrium and the left ventricle, and then pulmonary congestion, pulmonary hypertension, right ventricular hypertrophy, right atrial hypertrophy, right heart failure, and systemic circulation congestion occur in sequence.

[0003] In recent years, medical device companies at home and abroad have developed a variety of interventional clamping devices and corresponding delivery systems for treating mitral or tricuspid regurgitation. Taking mitral regurgitation as an example, the delivery device can puncture the atrial septum through the femoral vein of the catheter, and deliver the clamping device downward from the left atrium to near the mitral valve, and drive the clamping device to clamp and fix the free edges of the anterior and posterior leaflets of the mitral valve, so that the clamping device can complete the repair process by establishing a tissue bridge, reducing the phenomenon of mitral regurgitation.

[0004] However, the existing delivery systems for delivering clamping devices need to be improved. Taking the mitral valve clip, a clamping device for the mitral valve, as an example, the mitral valve clip will open and close repeatedly during the implantation process. Correspondingly, the operating components such as the intermediate wire in the delivery system also need to move repeatedly. During this process, due to deformation, aging and other reasons, the operating components will have travel redundancy, that is, the intermediate wire that controls the opening and closing of the mitral valve clip of the delivery device has moved to the limit position, while the clamping arms of the mitral valve clip cannot be fully closed, and the mitral valve clip cannot clamp the anterior and posterior leaflets of the mitral valve. This will lead to consequences such as clip detachment, patient bleeding, and unsuccessful surgery.

[0005] Therefore, there is a need in the art for a new delivery device and medical system for prostheses. Summary of the Invention

[0006] The purpose of the embodiments of the present invention is to provide a delivery device and a medical system, and the delivery device can drive the prosthesis to still work normally after multiple movements, improving the connection stability between the prosthesis and the delivery device.

[0007] To solve the above technical problems, the first aspect of the present invention provides a delivery device for a prosthesis, including:

[0008] A moving component, an intermediate wire, a stroke positioning member, and a housing; the housing includes an inner cavity; the moving component includes a moving member, a distal end of the moving member is disposed in the inner cavity of the housing, the moving member is movable relative to the housing along the axial direction of the housing, and the moving member is configured to drive the prosthesis to move by driving the intermediate wire to move axially; the stroke positioning member is movably passed through the housing to extend into the inner cavity; the stroke positioning member is configured such that when the moving member moves to a preset position and the prosthesis moves to a first position, the stroke positioning member abuts against the moving member to prevent the moving member from continuing to move; when the moving member moves to the preset position and the prosthesis does not move to the first position, the stroke positioning member is removed or at least partially moved to avoid the moving member, so that the moving member can continue to move, and further the prosthesis moves to the first position.

[0009] A second aspect of the present invention provides a medical system, including:

[0010] A prosthesis and the delivery device as described above, a distal end of the intermediate wire of the delivery device is detachably connected to the prosthesis.

[0011] Compared with the related art, the present embodiment includes a moving component, an intermediate wire, a stroke positioning member, and a housing. Among them, the housing has an inner cavity, the moving component includes a moving member whose distal end is disposed in the inner cavity of the housing, the moving member is axially movable relative to the housing, and the moving member is configured to drive the prosthesis to move by driving the intermediate wire to move axially. The stroke positioning member is movably passed through the housing to extend into the inner cavity. The stroke positioning member is configured such that when the moving member moves to a preset position and the prosthesis moves to a first position, the stroke positioning member abuts against the moving member to prevent the moving member from continuing to move, so as to prevent the delivery device and the prosthesis from being deformed or even damaged due to an unexpected external force; when the moving member moves to the preset position and the prosthesis does not move to the first position, the stroke positioning member is removed or at least partially moved to avoid the moving member, so that the moving member can continue to move, and further the prosthesis moves to the first position. That is to say, under normal circumstances, when the moving member moves to the preset position according to the preset stroke and the prosthesis moves to the first position, the operator is prevented from continuing to drive the moving member to move by the stroke positioning member; while in an abnormal situation, when the moving member moves to the preset position according to the preset stroke and the prosthesis does not move to the first position, the stroke positioning member can be removed or moved to avoid the moving member, thereby increasing the stroke of the moving member, so that the prosthesis can continue to move to the first position, improving the reliability of the delivery device. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] One or more embodiments are exemplarily illustrated by the pictures in the corresponding drawings. These exemplary illustrations do not constitute a limitation on the embodiments. Elements with the same reference numerals in the drawings are represented as similar elements, unless otherwise stated, the drawings in the figures do not constitute a scale limitation.

[0013] Figure 1 It is a schematic diagram of the proximal structure of the conveying device provided by the first embodiment of the present invention;

[0014] Figure 2 is Figure 1 A schematic cross-sectional view along line AA';

[0015] Figure 3 It is a schematic diagram of the structure of the moving component of the conveying device provided by the first embodiment of the present invention;

[0016] Figure 4 It is a schematic diagram of the proximal structure of the housing of the conveying device provided by the first embodiment of the present invention;

[0017] Figure 5 It is a schematic cross-sectional view of the handle of the conveying device provided by the first embodiment of the present invention;

[0018] Figure 6 It is a schematic cross-sectional view of the rotating shaft of the conveying device provided by the first embodiment of the present invention;

[0019] Figure 7 It is a schematic cross-sectional view of the moving part of the conveying device provided by the first embodiment of the present invention;

[0020] Figure 8 It is a schematic diagram of the structure of the mitral valve clip in the first embodiment of the present invention;

[0021] Figure 9a It is a schematic diagram of the structure of the expanded clamping arms of the mitral valve clip in the first embodiment of the present invention;

[0022] Figure 9b It is a schematic diagram of the structure of the closed clamping arms of the mitral valve clip in the first embodiment of the present invention;

[0023] Figure 10 It is a schematic cross-sectional view of the conveying device provided by the second embodiment of the present invention. Detailed embodiments

[0024] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the following will elaborate on each embodiment of the present invention in conjunction with the accompanying drawings. However, those of ordinary skill in the art can understand that in each embodiment of the present invention, many technical details are provided to help readers better understand the present application. Nevertheless, even without these technical details and various changes and modifications based on the following embodiments, the technical solutions claimed in the present application can still be implemented.

[0025] In the embodiments of the present invention, the terms "upper", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outer", "middle", "vertical", "horizontal", "lateral", "longitudinal", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. These terms are mainly used to better describe the present invention and its embodiments, and are not intended to limit that the indicated devices, elements, or components must have a specific orientation, or be constructed and operated in a specific orientation.

[0026] Moreover, in addition to being used to represent the orientation or positional relationship, some of the above terms may also be used to represent other meanings. For example, the term "upper" may also be used to represent a certain attachment relationship or connection relationship in some cases. For those of ordinary skill in the art, the specific meanings of these terms in the present invention can be understood according to specific circumstances.

[0027] In addition, the terms "mount", "set", "provided with", "opened", "connected", "coupled" should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or an integral structure; it may be a mechanical connection or an electrical connection; it may be directly connected, or indirectly connected through an intermediate medium, or there may be internal communication between two devices, elements, or components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0028] In addition, the terms "first", "second", etc. are mainly used to distinguish different devices, elements, or components (the specific types and structures may be the same or different), and are not intended to indicate or imply the relative importance and quantity of the indicated devices, elements, or components. Unless otherwise specified, the meaning of "a plurality" is two or more.

[0029] The first embodiment of the present invention relates to a conveying device for conveying a prosthesis, such as Figure 1 and Figure 2As shown in the figure, the core of this embodiment lies in that the conveying device includes a moving component 100, an intermediate wire 200, a stroke positioning member 300, and a housing 400. Among them, the housing 400 has an inner cavity 410. The moving component 100 includes a moving member 110 whose distal end is disposed in the inner cavity 410 of the housing 400. The moving member 110 can move relative to the housing 400 along the axial direction of the housing 400. The moving member 110 is used to drive the prosthesis to move by driving the intermediate wire 200 to move axially. The stroke positioning member 300 can movably pass through the housing 400 and extend into the inner cavity 410. The stroke positioning member 300 is configured to abut against the moving member 110 to prevent the moving member 110 from continuing to move when the moving member 110 moves to a preset position and the prosthesis moves to the first position; when the moving member 110 moves to the preset position while the prosthesis does not move to the first position, the stroke positioning member 300 is removed or at least partially moved to avoid the moving member 110, so that the moving member 110 continues to move, so that the prosthesis moves to the first position. That is to say, under normal circumstances, when the moving member 110 moves to the preset position according to the preset stroke, the prosthesis moves to the first position, and the operator is prevented from continuing to drive the moving member 110 to continue moving through the stroke positioning member 300; while in abnormal circumstances, when the moving member 110 moves to the preset position according to the preset stroke but the prosthesis does not move to the first position, at this time, it is necessary to continue to move the moving member 110 proximally to make the prosthesis move to the first position. Therefore, the stroke positioning member 300 can be removed or the stroke positioning member 300 can be moved to avoid the moving member 110, thereby increasing the stroke of the moving member 110, so that the prosthesis can continue to move to the first position, improving the reliability of the conveying device.

[0030] It should be noted that in the present invention, "proximal end" and "distal end" are relative position concepts. Generally speaking, the end close to the patient is the distal end, and the end close to the operator is the proximal end. For the conveying device, during use, the end close to the target position is the distal end, and the end close to the operation end is the proximal end.

[0031] The implementation details of the conveying device of this embodiment will be specifically described below. The following content is only the implementation details provided for convenience of understanding and is not necessary for implementing this solution. In this embodiment, the prosthesis is a mitral clip for clamping the leaflet edges of the anterior and posterior mitral valve leaflets to treat mitral regurgitation. However, this does not constitute a limitation of the present invention. The prosthesis can also be a tricuspid clip for clamping the leaflet edges of the tricuspid valve to treat tricuspid regurgitation. The prosthesis can also be a left atrial appendage occluder for preventing stroke caused by paroxysmal atrial fibrillation. The prosthesis can also be a retrievable valve stent. In addition, there is no specific limitation on the "first position" in the present invention. The "first position" refers to the prosthesis or the components and parts that the prosthesis can move to the desired posture and / or position. For example, in this embodiment, the first position refers to the preset limit closing position when the clamping arms in the mitral clip are close to each other and closed.

[0032] As Figure 8 , Figure 9a and Figure 9b shown, the mitral valve clip 600 of this embodiment includes a central base 610, clip arms 620 and a clip arm linkage 630. Among them, the clip arms 620 and the clip arm linkage 630 are rotatably connected to the central base 610. The clip arms 620 and the clip arm linkage 630 can move away from each other to accommodate the leaflets 700 of the mitral valve, and then move closer to each other to clamp and fix the leaflets 700. When the mitral valve clip 600 clamps the leaflets 700 in an inappropriate manner, the clip arms 620 and the clip arm linkage 630 move away from each other to release the leaflets 700, and then clamp the leaflets 700 again. Preferably, the clip arms 620 of the valve clip system of this embodiment include a first clip arm 621 and a second clip arm 622, and the first clip arm 621 and the second clip arm 622 are symmetrically arranged about the axis of the central base 610. Correspondingly, the clip arm linkage 630 of the valve clip system of this embodiment also includes a first clip arm linkage and a second clip arm linkage. The first clip arm linkage is used to cooperate with the first clip arm 621 to clamp one leaflet of the mitral valve, and the second clip arm linkage is used to cooperate with the second clip arm 622 to clamp the other leaflet of the mitral valve. In this embodiment, a detachable connection is adopted between the central base 610 and the distal end of the delivery device. For specific implementation manners, this embodiment does not limit this. For example, various coupling manners shown in the accompanying drawings of the specification and the relevant text in Chinese Patent Document CN102395331B, etc.

[0033] Furthermore, the mitral valve clip 600 further includes a braking assembly 640. The braking assembly 640 is used to drive the clip arms 620 to perform opening and closing movements around the central base 610 under the drive of the axial movement of the intermediate wire 200. The intermediate wire 200 moves axially towards the proximal end, and drives the first clip arm and the second clip arm to move closer to each other through the braking assembly. When the intermediate wire 200 moves axially towards the proximal end to a preset position, the first clip arm and the second clip arm are driven by the braking assembly to move closer to each other to a preset extreme closed position, that is, the first position.

[0034] Please continue to refer to Figure 9a and Figure 9b , the braking assembly 640 of this embodiment includes a first link 641, a second link 642 and a base 643. One end of the first link 641 is rotatably connected to the first clip arm 621, and the other end is rotatably connected to the base 643; one end of the second link 642 is rotatably connected to the second clip arm 622, and the other end is rotatably connected to the base 643. The base 643 includes a horizontal portion and a vertical portion. The two ends of the horizontal portion are respectively connected to the first link 641 and the second link 642, and the vertical portion is received in the central base 610 and can move relative to the central base 610.

[0035] Specifically, the base 643 of this embodiment is in a "T" shape. Both ends of the horizontal part of the base 643 are respectively connected to the first connecting rod 641 and the second connecting rod 642. The vertical part is received in the central base 610 and can be movably connected to the central base 610. For example, the first connecting rod 641, the second connecting rod 642, the first clamping arm 621, the second clamping arm 622, the base 643, and the central base 610 form a link mechanism similar to a crank-slider mechanism by pin connection. Under the action of the force acting on the vertical part, the first clamping arm 621 and the second clamping arm 622 are rotated through the link mechanism to realize the clamping of the edge of the mitral valve leaflet.

[0036] In this embodiment, the moving assembly 100 further includes a driving member 120. The distal end of the driving member 120 is disposed in the inner cavity 410 of the housing 400, and the driving member 120 is configured to be rotatable only relative to the housing 400. The moving member 110 is configured to be axially movable only relative to the housing 400. And the moving member 110 is configured to be axially movable only relative to the housing 400, that is, the moving member 110 cannot rotate relative to the housing 400.

[0037] Please refer to Figure 3 and Figure 4 , specifically, the driving member 120 has an internal thread, and the moving member 110 has an external thread that is threadedly connected to the internal thread. The proximal end of the housing 400 is further provided with a proximal opening 420, and the proximal opening 420 is constricted to form an opening shoulder 421. The distal end of the driving member 120 is provided with an axially extending opening groove 121, and the opening shoulder 421 is received in the opening groove 121 so that the driving member 120 is restricted to rotate only relative to the housing 400.

[0038] On the other hand, a first restricting member is provided on the outer side of the distal end of the moving member 110, and a second restricting member is provided on the housing 400 at the corresponding position. The first restricting member and the second restricting member are configured to be axially movably connected along the housing 400 so that the moving member 110 is restricted to be axially movable only relative to the housing 400.

[0039] More specifically, the first restricting member is a limiting protrusion, and the second restricting member is a limiting groove. Among them, the limiting protrusion is arranged perpendicular to the axis of the housing 400, and both the limiting groove and the limiting protrusion extend along the axis of the housing 400. One end of the limiting protrusion is fixed to the outer periphery of the moving member 110, and the other end is received in the limiting groove. When the driving member 120 rotates, since the limiting protrusion is embedded in the limiting groove, the inner side wall of the limiting groove provided on the housing blocks the rotation of the limiting protrusion, thereby blocking the rotation of the moving member 110. In an alternative embodiment, the first restricting member is an axially arranged limiting groove, and the second restricting member is a limiting protrusion arranged perpendicular to the axis of the housing 400. One end of the limiting protrusion is fixed to the outer periphery of the housing 400, and the other end is received in the limiting groove.

[0040] In this embodiment, when the driving member 120 rotates in the clockwise direction (observed from the left side to the right side of Figure 5 ), the moving member 110 moves toward the proximal end relative to the housing 400 under the drive of the driving member 120; when the driving member 120 rotates in the counterclockwise direction, the moving member 110 moves toward the distal end relative to the housing 400 under the drive of the driving member 120. Of course, in other alternative embodiments, when the driving member 120 rotates in the clockwise direction, the moving member 110 moves toward the distal end relative to the housing 400 under the drive of the driving member 120; when the driving member 120 rotates in the counterclockwise direction, the moving member 110 moves toward the proximal end relative to the housing 400 under the drive of the driving member 120.

[0041] In this embodiment, the moving member 110 is integrally in the shape of a cylindrical tube, the driving member 120 is in the shape of a tube with a through hole, and the distal portion of the moving member 110 passes through the through hole of the driving member 120 and extends into the inner cavity 410 of the housing 400. Optionally, the driving member 120 can be in the shape of a cylindrical tube or a polygonal prism tube.

[0042] Continuing to refer to Figure 3 and Figure 7 , in this embodiment, a holding portion 111 is provided at the distal end of the moving member 110 for holding the stroke positioning member 300. Therefore, the outer dimension of the holding portion 111 in the direction perpendicular to the axis of the housing 400 matches the inner dimension of the stroke positioning member 300 in the direction perpendicular to the axis of the housing 400. That is to say, the distance from the outer contour of the holding portion 111 to the axis of the housing 400 is greater than the distance from the end face of the stroke positioning member 300 located in the inner cavity 410 to the axis direction of the housing 400, so as to ensure that the moving member 110 can contact the stroke positioning member 300 when moving toward the proximal end.

[0043] Specifically, there are a plurality of holding portions 111, which are arranged at intervals along the circumferential direction of the moving member 110. The stroke positioning member 300 is also provided in a plurality, and is arranged at intervals along the circumferential direction of the housing 400. The plurality of holding portions 111 and the plurality of stroke positioning members 300 are arranged in a one-to-one correspondence in the circumferential direction so that the holding portion 111 can hold the stroke positioning member 300. By arranging the holding portions 111 in a plurality and spaced along the circumferential direction of the moving member 110, and arranging the stroke positioning member 300 in a plurality and in a one-to-one correspondence with the holding portions 111, when the moving member 110 moves to a preset position, the holding portion 111 and the stroke positioning member 300 start to contact, and the interaction between the holding portion 111 and the stroke positioning member 300 is relatively balanced.

[0044] In other embodiments, the holding portion 111 is continuously provided along the outer circumference of the moving member 110, and the proximal end of the holding portion 111 holds the distal end of the part of the stroke positioning member 300 located in the inner cavity 410.

[0045] More specifically, the abutting portion 111 is a convex structure disposed on the surface of the moving member 110 and extending in a direction perpendicular to the axis of the moving member 110, and is located at the distal end of the stroke positioning member 300. Optionally, the convex structure may be integrally formed with the moving member 110 or may be an independent structure fixedly connected to the moving member 110. It can be understood that when the abutting portion 111 is continuously disposed along the outer periphery of the moving member 110, the abutting portion 111 may be an annular boss continuously disposed around the outer periphery of the moving member 110.

[0046] Preferably, a chute 430 extending along the axis of the outer shell 400 is provided on the wall surface of the inner cavity 410 of the outer shell 400. At least a part of the convex structure, for example, the part close to the inner wall of the outer shell 400, is received in the chute 430 and can move in the chute 430, so that the moving member 110 is restricted to move axially relative to the outer shell 400 only. That is to say, when the chute 430 provided on the inner side wall of the outer shell 400 functions as a second restricting member; and the convex structure also functions as a first restricting member at the same time. In this way, in addition to being able to squeeze the stroke positioning member 300 under the drive of the driving member 120 to increase the stroke of the intermediate wire 200, the abutting portion 111 can also restrict the rotation of the moving member 110. In this way, the first restricting member can be omitted, and the structure of the moving member 110 can be further simplified.

[0047] Continue to refer to Figure 2 , a receiving through hole 440 communicating with the inner cavity 410 is provided on the outer shell 400, and the receiving through hole 440 is provided at the proximal end of a preset position. Through the receiving through hole 440, the stroke positioning member 300 can movably pass through the outer shell 400 and enter the inner cavity 410.

[0048] In this embodiment, the stroke positioning member 300 and the outer shell 400 are threadedly connected, that is, there is a threaded structure between the stroke positioning member 300 and the outer shell 400. Specifically, the stroke positioning member 300 has an external thread, and the inner wall of the receiving through hole 440 has an internal thread, and the stroke positioning member 300 and the outer shell 400 are connected by a thread. At this time, the stroke positioning member 300 may be a bolt. When it is necessary to move the stroke positioning member 300 to avoid the abutting portion 111, the stroke positioning member 300 can be screwed out and separated. Of course, as long as the stroke positioning member 300 can avoid the abutting portion 111 so that the moving member 110 can continue to move toward the proximal end, the stroke positioning member 300 does not need to be rotated to completely disengage from the outer shell 400.

[0049] The stroke locating member 300 and the housing 400 can also be other detachable connection modes. In an alternative embodiment, the stroke locating member 300 is connected to the housing 400 by snapping. For example, there is a snap-fit ​​structure between the stroke locating member 300 and the housing 400. When the stroke locating member 300 is snap-fitted to the housing 400, the movable member 110 moves to a preset position toward the proximal end, and the abutting portion 111 and the stroke locating member 300 abut, and the movable member 110 cannot continue to move toward the proximal end. When necessary, the stroke locating member 300 can be moved or directly removed by unfastening the snap, so that the stroke locating member 300 avoids the abutting portion 111, and then the movable member 110 can continue to move toward the proximal end. The connection relationship between the stroke locating member 300 and the housing 400 is set to snap-fit, which can further reduce the difficulty of operation relative to the threaded connection method.

[0050] In another embodiment, the accommodating through hole 440 extends along the circumference of the housing 400. The stroke positioning member 300 can slide on the accommodating through hole 440. Under normal circumstances, the circumferential position of the stroke positioning member 300 is consistent with the circumferential position of the abutting portion 111. When the movable member 110 moves to the preset position, the clamping arms of the mitral valve clip are brought close to each other and closed to the preset extreme closing position (i.e., the first position), and the abutting portion 111 begins to abut the stroke positioning member 300. In an abnormal situation, when the movable member 110 moves to the preset position, the clamping arms of the mitral valve clip are not brought close to each other and closed to the preset extreme closing position, then the stroke positioning member 300 needs to be slid on the accommodating through hole 440 to achieve circumferential staggering with the abutting portion 111.

[0051] Specifically, the accommodating through hole 440 is in the shape of an elongated strip and extends along the circumference of the housing 400. The stroke positioning member 300 includes an extension portion 310 and an insertion portion 320 connected to the extension portion 310, the extension portion 310 is located outside the housing 400, and the insertion portion 320 extends into the inner cavity 410 via the accommodating through hole 440. The extension portion 310 is used to drive the insertion portion 320 to move to abut or avoid the abutting portion 111. The extension portion 310 and the insertion portion 320 are configured to prohibit the stroke positioning member 300 from moving in a direction perpendicular to the axis of the housing 400, and can move along the extension direction of the accommodating through hole 440, that is, the stroke positioning member 300 will not detach from the accommodating through hole 440, and can only move circumferentially around the housing 400 in the accommodating through hole 440. Thus, under normal circumstances, the insertion portion 320 abuts against the abutting portion 111 to prevent the abutting portion 111 from continuing to move toward the proximal end, and when necessary, the operator can push the extension portion 310 to slide along the extension direction of the accommodating through hole 440 to drive the insertion portion 320 to slide, so that the insertion portion 320 avoids the abutting portion 111, and then the abutting portion 111 can continue to move toward the proximal end. By operating the travel positioning member 300 in a manner similar to operating a sliding button, the difficulty of operating the conveying device can be further reduced.

[0052] More specifically, the size of the corresponding parts of the extending portion 320 on both sides of the accommodating through hole 440 is larger than the size of the accommodating through hole 440. The cross section of the extending portion 320 is formed similar to an "I" shape, thereby forming an accommodating groove, so that the edge surrounding the accommodating through hole 440 extends into the accommodating groove, even if the stroke positioning member 300 and the housing 400 are mutually engaged, the stroke positioning member 300 is prevented from being separated from the housing. In this embodiment, the number of the stroke positioning member 300 and the accommodating through hole 440 is not specifically limited.

[0053] In this embodiment, in order to enable the abutting portion 111 to continue to move toward the proximal end after the insertion portion 320 moves, the abutting portion 111 can be configured as a protruding structure disposed on the surface of the moving member 110 and extending perpendicularly to the axial direction of the moving member 110 .

[0054] Preferably, the circumferential length of the accommodating through hole 440 in the housing 400 is configured so that when the stroke positioning member 300 moves to one side, the stroke positioning member 300 is circumferentially staggered with the abutting portion 111, and when the stroke positioning member 300 moves to the other side, the stroke positioning member 300 is circumferentially overlapped with the abutting portion 111.

[0055] In some embodiments, the outer shell 400 is cylindrical. At this time, a plurality of abutting portions 111, stroke positioning members 300, and receiving through holes 440 can be provided. Among them, the plurality of abutting portions 111 are arranged at intervals along the circumferential direction of the moving member 110, and the plurality of stroke positioning members 300 and the plurality of receiving through holes 440 are both arranged at intervals along the circumferential direction of the outer shell 400, and the stroke positioning members 300 and the receiving through holes 440 are arranged in one-to-one correspondence. In order to further reduce the operation difficulty, the outer extension portions 310 of each stroke positioning member 300 can be connected. In this way, when the operator rotates any one of the outer extension portions 310, the other outer extension portions 310 will also be driven, thereby driving all the extending portions 320 to move, and further enabling all the extending portions 320 to avoid all the abutting portions.

[0056] In the present embodiment, the conveying device further includes a wire clamping assembly 500. The wire clamping assembly 500 is rotatably received in the moving assembly 100 and is fixedly connected to the intermediate wire 200. The proximal end of the intermediate wire 200 is fixedly connected to the wire clamping assembly 500, and the distal end of the intermediate wire 200 is detachably connected to the prosthesis. Therefore, when the wire clamping assembly 500 is rotated, the mitral valve clip 600 can be separated from the intermediate wire 200. When the wire clamping assembly 500 moves axially along the outer shell 400, it can drive the intermediate wire 200 to move axially to open and close the clamping arms 620 of the mitral valve clip 600.

[0057] Please refer to Figure 5 and Figure 7 , the wire clamping assembly 500 includes a rotating shaft 510 and a handle 520 located at the proximal end of the rotating shaft 510. The handle 520 and the rotating shaft 510 are detachably connected. Specifically, the handle 520 includes a handle end at the proximal end and a first coupling end 522 at the distal end. The handle end is used for the operator to operate the rotation of the wire clamping assembly 500, and the first coupling end is used to couple with the rotating shaft 510 and clamp the intermediate wire 200. The handle 520 has a middle cavity 521 for receiving the intermediate wire 200. The rotating shaft 510 is generally cylindrical. The proximal end of the rotating shaft 510 has a second coupling end 513 for coupling with the first coupling end 522 to fix the intermediate wire 200. Exemplarily, the first coupling end 522 has an external thread, the second coupling end 513 has an internal thread, and a plurality of axially extending gaps are provided at intervals in the circumferential direction of the first coupling end 522. When the first coupling end 522 and the second coupling end 513 are threadedly connected, the gaps become smaller, and thus the middle cavity 521 becomes smaller to fix the proximal end of the intermediate wire 200. The rotating shaft 510 has a receiving cavity 511 for receiving the intermediate wire 200. The middle cavity 521 and the receiving cavity 511 are communicated to provide a channel for the intermediate wire 200 to extend from the proximal end to the distal end.

[0058] Specifically, the moving member 110 has an axially penetrating channel. The proximal end of the handle 520 is disposed outside the proximal end of the moving member 110, and at least a part of the rotating shaft 510 is rotatably received in the channel. Thus, by driving the handle 520, the intermediate wire 200 can be driven to rotate relative to the moving member 110.

[0059] Furthermore, the wire clamping assembly 500 further includes a one-way rotating member 530. The one-way rotating member 530 is located between the moving member 110 and the rotating shaft 510. The one-way rotating member 530 is configured to rotate the wire clamping assembly 500 in a first direction and prevent the wire clamping assembly 500 from rotating in a second direction, where the first direction and the second direction are opposite. Specifically, the one-way rotating member 530 of the present embodiment is disposed at the distal ends of the wire clamping assembly 500 and the moving member 110 to allow the wire clamping assembly 500 to rotate in the first direction and prevent it from rotating in the second direction, thereby preventing excessive coupling between the intermediate wire 200 and the mitral valve clip 600 that cannot be released. There is no particular limitation on the type of the one-way rotating member 530 in the present embodiment. Exemplarily, the one-way rotating member 530 can be a one-way bearing or a ratchet and pawl member.

[0060] Preferably, the one-way rotating member 530 of the present embodiment is a ratchet and pawl member. Specifically, the one-way rotating member 530 includes a ratchet and a pawl. The ratchet is disposed at the distal end of the rotating shaft 510, and the pawl is configured to be fixed at the distal end of the moving member 110. Through the cooperation of the ratchet and the pawl, the wire clamping assembly 500 can rotate relative to the moving member 110 in the first direction and cannot rotate in the second direction, which is opposite to the first direction.

[0061] Please refer to Figures 5 to 7 again. The wire clamping assembly 500 further includes a positioning pin 540. The moving member 110 is provided with a first positioning through slot 112, and the outer wall of the rotating shaft 510 is provided with a second positioning through slot 512. The cross-sectional shape of the first positioning through slot 112 and the cross-sectional shape of the second positioning through slot 512 are configured to cooperate with each other to form a closed shape, so that the first positioning through slot 112 and the second positioning through slot 512 after cooperation form a positioning through hole 550. The positioning pin 540 is inserted through the positioning through hole 550 to prevent relative movement between the moving member 110 and the rotating shaft 510. Specifically, after the first positioning through slot 112 and the second positioning through slot 512 are aligned and cooperate to form a positioning through hole 550, the positioning pin 540 abuts against the inner side wall of the first positioning through slot 112 and the inner side wall of the second positioning through slot 512 after extending into the positioning through hole 550, thereby relatively fixing the moving member 110 and the rotating shaft 510. Only when the moving member 110 moves, the rotating shaft 510 will follow the movement, and at the same time, the rotating shaft 510 cannot rotate, which can avoid premature unwinding of the prosthesis due to misoperation during the delivery of the prosthesis.

[0062] The second embodiment of the present invention provides a medical system, such asFigures 1 to 10 As shown, it includes a prosthesis and the delivery device described in the above first embodiment. The distal end of the intermediate wire 200 of the delivery device is detachably connected to the prosthesis.

[0063] Specifically, the prosthesis is a valve clip for clamping the edge of the native leaflet, such as the mitral valve clip described in the above embodiment. It can be understood that the prosthesis can also be other types of implantable prostheses.

[0064] The delivery device and medical system provided by the embodiments of the present invention have been introduced in detail above. Specific examples are used herein to elaborate on the principle and embodiments of the present invention. The description of the above embodiments is only for helping to understand the idea of the present invention, and there will be changes in the specific embodiments and application scopes. In summary, the content of this specification should not be construed as a limitation on the present invention.

Claims

1. A delivery device for a prosthesis, characterized in that, it includes: a moving component, an intermediate wire, a stroke positioning member, and a housing; the housing includes an inner cavity; the moving component includes a moving member, the distal end of the moving member is disposed in the inner cavity of the housing, the moving member can move axially relative to the housing, and the moving member is used to drive the prosthesis to move by driving the intermediate wire axially; the stroke positioning member is movably passed through the housing to extend into the inner cavity; the stroke positioning member is configured such that when the moving member moves to a preset position and the prosthesis moves to a first position, the stroke positioning member abuts against the moving member to prevent the moving member from continuing to move; when the moving member moves to the preset position and the prosthesis does not move to the first position, the stroke positioning member is removed or at least partially moved to avoid the moving member, so that the moving member can continue to move, and further the prosthesis moves to the first position.

2. The delivery device according to claim 1, characterized in that, the moving component further includes a driving member, the distal end of the driving member is disposed in the inner cavity of the housing, and the driving member is configured to be rotatable only relative to the housing, and the moving member is configured to be axially movable only relative to the housing.

3. The delivery device according to claim 2, characterized in that, the driving member has an internal thread, and the moving member has an external thread threadedly connected to the internal thread; a proximal opening is further provided at the proximal end of the housing, and the proximal opening is constricted to form an opening shoulder; a circumferentially extending opening groove is provided at the distal end of the driving member, and the opening shoulder is received in the opening groove, so that the driving member is restricted to be rotatable only relative to the housing; a first restricting member is provided on the outer side of the distal end of the moving member, and a second restricting member is provided on the housing at the corresponding position, and the first restricting member and the second restricting member are configured to be axially movably connected along the housing, so that the moving member is restricted to be axially movable only relative to the housing.

4. The delivery device according to claim 1, characterized in that, a abutting portion is provided at the distal end of the moving member, and the outer dimension of the abutting portion in a direction perpendicular to the axis of the housing matches the inner dimension of the stroke positioning member in a direction perpendicular to the axis of the housing to abut against the stroke positioning member.

5. The delivery device according to claim 4, characterized in that, the abutting portion is continuously provided along the outer circumference of the moving member, and the proximal end of the abutting portion abuts against the distal end of the part of the stroke positioning member located in the inner cavity.

6. The delivery device according to claim 4, characterized in that, the abutting portions are multiple and are circumferentially spaced along the moving member; the stroke positioning members are also multiple and are circumferentially spaced along the housing; the multiple abutting portions and the multiple stroke positioning members are arranged in one-to-one correspondence in the circumferential direction, so that the abutting portions can abut against the stroke positioning members.

7. The delivery device according to claim 6, characterized in that, The abutting portion is a protruding structure which is arranged on the surface of the moving member and extends perpendicularly to the axial direction of the moving member, and the protruding structure is located at the far end of the stroke positioning member.

8. The conveying device according to claim 7, It is characterized in that The wall surface of the inner cavity of the shell is provided with a slide groove extending along the axial direction of the shell, and the protruding structure is at least partially accommodated in the slide groove and can move in the slide groove, so that the moving part is restricted and can only move relative to the shell.

9. The conveying device according to any one of claims 1 to 6, It is characterized in that The shell is provided with an accommodating through hole communicating with the inner cavity, and the travel positioning member is detachably connected to the accommodating through hole.

10. The conveying device according to claim 9, It is characterized in that The stroke positioning member has an external thread, and the inner wall of the accommodating through hole has an internal thread, so that the stroke positioning member and the shell are threadedly connected.

11. The conveying device according to claim 9, It is characterized in that The travel positioning member passes through the accommodating through hole and is engaged with the accommodating through hole.

12. The conveying device according to claim 4, It is characterized in that The outer shell is provided with an accommodating through hole connected to the inner cavity, and the accommodating through hole extends along the circumference of the outer shell; the stroke positioning member can slide on the accommodating through hole; and the stroke positioning member is configured to be able to slide to maintain circumferential consistency with the abutting portion, and also to be able to slide to be staggered circumferentially with the abutting portion.

13. The conveying device according to claim 12, It is characterized in that The travel positioning member comprises an extension portion and an insertion portion connected to the extension portion, the extension portion is located outside the housing, and the insertion portion extends into the inner cavity via the accommodating through hole; The extension portion and the protrusion portion are configured to prohibit the travel positioning member from moving in a direction perpendicular to the axis of the housing, and to be able to move in an extension direction of the accommodating through hole.

14. The conveying device according to claim 12 or 13, It is characterized in that The circumferential length of the accommodating through hole in the shell is configured so that when the stroke positioning member is located on one side of the accommodating through hole, the stroke positioning member and the abutting portion are staggered in the circumferential direction, and when the stroke positioning member is located on the other side of the accommodating through hole, the stroke positioning member and the abutting portion overlap in the circumferential direction.

15. The conveying device according to claim 2, It is characterized in that It also includes a wire clamping assembly, which is rotatably accommodated in the moving assembly and fixedly connected to the intermediate wire; The moving part has an axially penetrating channel, the wire clamping assembly is at least partially rotatably accommodated in the channel, and the wire clamping assembly drives the prosthesis to rotate via the intermediate wire.

16. The conveying device according to claim 15, It is characterized in that The wire clamping assembly includes a rotating shaft and a handle located at the proximal end of the rotating shaft. The handle has a middle cavity for accommodating the intermediate wire, and the rotating shaft has a receiving cavity for accommodating the intermediate wire. The middle cavity and the receiving cavity are in communication; the handle is coupled to the rotating shaft to fix the intermediate wire.

17. The delivery device according to claim 16, wherein, the wire clamping assembly further includes a one-way rotating member located between the moving member and the rotating shaft. The one-way rotating member is configured to rotate the wire clamping assembly in a first direction and prevent the wire clamping assembly from rotating in a second direction, where the first direction and the second direction are opposite.

18. The delivery device according to claim 16, wherein, the wire clamping assembly further includes a positioning pin; the moving member is provided with a first positioning through slot, and the outer wall of the rotating shaft is provided with a second positioning through slot. The cross-sectional shape of the first positioning through slot and the cross-sectional shape of the second positioning through slot are configured to be complementary to form a closed shape, so that the first positioning through slot and the second positioning through slot after fitting form a positioning through hole; the positioning pin is inserted through the positioning through hole to prevent relative movement between the moving member and the rotating shaft.

19. A medical system, wherein, it includes a prosthesis and the delivery device according to any one of claims 1-18. The distal end of the intermediate wire of the delivery device is detachably connected to the prosthesis.

20. The medical system according to claim 19, wherein, the prosthesis is a valve clip for clamping the edge of the native leaflet.

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