Conveyor device and medical system

Abstract

An embodiment of the present invention relates to the technical field of medical devices, and discloses a delivery device for a prosthesis, which includes a moving component, an intermediate wire, a stroke positioning member, and a housing; the housing includes an inner cavity; the moving component includes a moving member, the distal end of the moving member is disposed in the inner cavity of the housing, the moving member can move relative to the housing along the axial direction of the housing, and the moving member is used to drive the prosthesis to move by driving the axial movement of the intermediate wire; the stroke positioning member has elasticity and is accommodated in the inner cavity of the housing; the stroke positioning member is configured to, when the moving member moves to a preset position and the prosthesis moves to a first position, the stroke positioning member abuts against the moving member to prevent the moving member from continuing to move; when the moving member moves to the preset position while the prosthesis does not move to the first position, the moving member overcomes the elastic force generated by the elastic deformation of the stroke positioning member and continues to move so that the prosthesis moves to the first position. The present invention also discloses a medical system, which includes the delivery device and the prosthesis as described above.

Description

Technical Field

[0001] The embodiments of the present invention relate to the technical field of medical devices, and particularly to a delivery device and a medical system. Background Art

[0002] The mitral valve is composed of two valve leaflets attached to the periphery of the left atrioventricular orifice, which can prevent the blood in the left ventricle from flowing back into the left atrium. Organic or functional changes in the mitral valve and its related structures will lead to poor anastomosis of the anterior and posterior leaflets of the mitral valve, resulting in blood reflux from the left ventricle to the left atrium. When the heart contracts, the left atrium simultaneously receives the blood refluxed from the left ventricle and the blood input from the pulmonary veins. The blood volume in the left atrium increases significantly and the pressure rises, leading to left atrial hypertrophy. When the heart relaxes, more blood flows from the left atrium to the left ventricle, causing the left ventricle to hypertrophy due to enhanced contraction. After evolving from the compensatory stage to the decompensated stage, heart failure occurs in both the left atrium and the left ventricle, and then pulmonary congestion, pulmonary hypertension, right ventricular hypertrophy, right atrial hypertrophy, right heart failure, and systemic congestion occur in sequence.

[0003] In recent years, medical device companies at home and abroad have developed a variety of interventional clamping devices and corresponding delivery systems for treating mitral or tricuspid regurgitation. Taking mitral regurgitation as an example, the delivery device can puncture the atrial septum through the femoral vein of the catheter, deliver the clamping device downward from the left atrium to near the mitral valve, and drive the clamping device to clamp and fix the free edges of the anterior and posterior leaflets of the mitral valve, so that the clamping device completes the repair process by establishing a tissue bridge and reduces the phenomenon of mitral regurgitation.

[0004] However, the existing delivery systems for delivering clamping devices need to be improved. Taking the mitral clip, a clamping device for the mitral valve, as an example, the mitral clip will open and close repeatedly during the implantation process. Correspondingly, the operating components such as the intermediate wire in the delivery system also need to move repeatedly. During this process, due to deformation, aging, etc., the operating components will have travel redundancy, that is, the intermediate wire that controls the opening and closing of the mitral clip of the delivery device has moved to the limit position, while the clamping arms of the mitral clip cannot be fully closed, and the mitral clip cannot clamp the anterior and posterior leaflets of the mitral valve. This will lead to consequences such as clip detachment, patient bleeding, and unsuccessful surgery.

[0005] Therefore, there is a need in the art for a new delivery device for a prosthesis and a medical system. Summary of the Invention

[0006] The purpose of the embodiments of the present invention is to provide a delivery device and a medical system. The delivery device can drive the prosthesis to still work normally after multiple movements, and improve the connection stability between the prosthesis and the delivery device.

[0007] To solve the above technical problems, the first aspect of the present invention provides a delivery device for a prosthesis, including:

[0008] A moving component, an intermediate wire, a stroke positioning member, and a housing; the housing includes an inner cavity; the moving component includes a moving member, the distal end of the moving member is disposed in the inner cavity of the housing, the moving member can move relative to the housing along the axial direction of the housing, and the moving member is used to drive the prosthesis to move by driving the axial movement of the intermediate wire; the stroke positioning member has elasticity and is accommodated in the inner cavity of the housing; the stroke positioning member is configured to abut against the moving member to prevent the moving member from continuing to move when the moving member moves to a preset position and the prosthesis moves to a first position; when the moving member moves to the preset position while the prosthesis does not move to the first position, the moving member overcomes the elastic force generated by the elastic deformation of the stroke positioning member and continues to move so that the prosthesis moves to the first position.

[0009] A second aspect of the present invention provides a medical system, including:

[0010] A prosthesis and the delivery device as described above, and the distal end of the intermediate wire of the delivery device is detachably connected to the prosthesis.

[0011] Compared with the related art, the embodiment of the present invention includes a moving component, an intermediate wire, a stroke positioning member, and a housing. Among them, the housing has an inner cavity, the moving component includes a moving member whose distal end is disposed in the inner cavity of the housing, the moving member can move relative to the housing along the axial direction of the housing, and the moving member is used to drive the prosthesis to move by driving the axial movement of the intermediate wire. The stroke positioning member has elasticity and is accommodated in the inner cavity of the housing. The stroke positioning member is configured to abut against the moving member to prevent the moving member from continuing to move when the moving member moves to a preset position and the prosthesis moves to a first position, so as to prevent the delivery device and the prosthesis from receiving unexpected external forces and causing plastic deformation or even fracture damage; when the moving member moves to the preset position while the prosthesis does not move to the first position, the moving member overcomes the elastic force generated by the elastic deformation of the stroke positioning member and continues to move so that the prosthesis moves to the first position. That is to say, under normal circumstances, when the moving member moves to the preset position according to the preset stroke, the prosthesis moves to the first position, and the operator is prevented from continuing to drive the moving member to continue moving through the stroke positioning member; while in abnormal circumstances, when the moving member moves to the preset position according to the preset stroke and the prosthesis does not move to the first position, the moving member can squeeze the stroke positioning member to increase the stroke of the moving member, so that the prosthesis can continue to move to the first position, improving the reliability of the delivery device. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] One or more embodiments are illustrated by way of example in the accompanying drawings, which do not constitute a limitation on the embodiments. Elements with the same reference numerals in the drawings represent similar elements, and unless otherwise stated, the figures in the drawings do not constitute a scale limitation.

[0013] Figure 1 It is a schematic diagram of the proximal structure of the conveying device provided by the first embodiment of the present invention;

[0014] Figure 2 is Figure 1 A schematic sectional view along line AA';

[0015] Figure 3 It is a schematic diagram of the structure of the moving component of the conveying device provided by the first embodiment of the present invention;

[0016] Figure 4 It is a schematic diagram of the proximal structure of the housing of the conveying device provided by the first embodiment of the present invention;

[0017] Figure 5 is Figure 1 A schematic sectional view along a straight line perpendicular to line AA';

[0018] Figure 6 It is a schematic sectional view of the handle of the conveying device provided by the first embodiment of the present invention;

[0019] Figure 7 It is a schematic sectional view of the rotating shaft of the conveying device provided by the first embodiment of the present invention;

[0020] Figure 8 It is a schematic sectional view of the moving part of the conveying device provided by the first embodiment of the present invention;

[0021] Figure 9 It is a schematic diagram of the structure of the mitral valve clip in the first embodiment of the present invention;

[0022] Figure 10a It is a schematic diagram of the structure of the expanded clamping arms of the mitral valve clip in the first embodiment of the present invention;

[0023] Figure 10b It is a schematic diagram of the structure of the closed clamping arms of the mitral valve clip in the first embodiment of the present invention. Detailed implementation manners

[0024] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the following will elaborate on each embodiment of the present invention in conjunction with the accompanying drawings. However, those of ordinary skill in the art can understand that in each embodiment of the present invention, many technical details are provided to help readers better understand the present application. However, even without these technical details and various changes and modifications based on the following embodiments, the technical solutions claimed in the present application can still be implemented.

[0025] In the embodiments of the present invention, the terms "upper", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outer", "middle", "vertical", "horizontal", "lateral", "longitudinal", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. These terms are mainly used to better describe the present invention and its embodiments, and are not used to limit that the indicated devices, elements, or components must have a specific orientation, or be constructed and operated in a specific orientation.

[0026] Moreover, in addition to being used to represent the orientation or positional relationship, some of the above terms may also be used to represent other meanings. For example, the term "upper" may also be used to represent a certain attachment relationship or connection relationship in some cases. For those of ordinary skill in the art, the specific meanings of these terms in the present invention can be understood according to specific circumstances.

[0027] In addition, the terms "install", "set", "provide", "open", "connect", and "couple" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral structure; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, or there can be internal communication between two devices, elements, or components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0028] In addition, the terms "first", "second", etc. are mainly used to distinguish different devices, elements, or components (the specific types and structures may be the same or different), and are not used to indicate or imply the relative importance and quantity of the indicated devices, elements, or components. Unless otherwise specified, the meaning of "plurality" is two or more.

[0029] The first embodiment of the present invention relates to a conveying device for conveying a prosthesis, such as Figure 1 and Figure 2As shown in the figure, the core of this embodiment lies in that the conveying device includes a moving assembly 100, an intermediate wire 200, a stroke positioning member 300, and a housing 400. Among them, the housing 400 has an inner cavity 410. The moving assembly 100 includes a moving member 110 with its distal end disposed in the inner cavity 410 of the housing 400. The moving member 110 is axially movable relative to the housing 400 along the axis of the housing 400, and the moving member 110 is used to drive the prosthesis to move by driving the axial movement of the intermediate wire 200. The stroke positioning member 300 is elastic and is accommodated in the inner cavity 410 of the housing 400. The stroke positioning member 300 is configured to abut against the moving member 110 to prevent the moving member 110 from continuing to move when the moving member 110 moves to a preset position and the prosthesis moves to the first position; when the moving member 110 moves to the preset position while the prosthesis does not move to the first position, the moving member 110 overcomes the elastic force generated by the elastic deformation of the stroke positioning member 300 and continues to move so that the prosthesis moves to the first position. That is to say, under normal circumstances, when the moving member 110 moves to the preset position according to the preset stroke, the prosthesis moves to the first position. If the moving member 110 is continuously driven to move, it will be blocked by the elastic force generated by the deformation of the stroke positioning member 300 to remind the operator to stop driving the moving member; in abnormal circumstances, when the moving member moves to the preset position according to the preset stroke while the prosthesis does not move to the first position, the operator can squeeze the stroke positioning member 300 through the moving member 110 to increase the stroke of the moving member 110, so that the prosthesis can continue to move to the first position, improving the reliability of the conveying device.

[0030] It should be noted that in the present invention, "proximal end" and "distal end" are relative position concepts. Generally speaking, the end close to the patient is the distal end, and the end close to the operator is the proximal end. For the conveying device, during use, the end close to the target position is the distal end, and the end close to the operation end is the proximal end.

[0031] The implementation details of the conveying device of this embodiment are specifically described below. The following content is only the implementation details provided for convenience of understanding and is not necessary for implementing this solution. In this embodiment, the prosthesis is a mitral clip for clamping the anterior and posterior leaflet edges of the mitral valve to treat mitral regurgitation. However, this does not constitute a limitation to the present invention. The prosthesis can also be a tricuspid clip for clamping the leaflet edges of the tricuspid valve to treat tricuspid regurgitation. The prosthesis can also be a left atrial appendage occluder for preventing stroke caused by paroxysmal atrial fibrillation. The prosthesis can also be a retrievable valve stent. In addition, there is no specific limitation on the "first position" in the present invention. The "first position" refers to the desired posture and / or position when the prosthesis or the movable components and parts of the prosthesis move. For example, in this embodiment, the first position refers to the preset limit closing position when the clamping arms in the mitral clip are close to each other and closed.

[0032] As Figure 9, Figure 10a and Figure 10b As shown in Figure 10a and Figure 10b , the mitral valve clip 600 of this embodiment includes a central base 610, clip arms 620 and a clip arm linkage 630. Among them, the clip arms 620 and the clip arm linkage 630 are rotatably connected to the central base 610. The clip arms 620 and the clip arm linkage 630 can move away from each other to accommodate the valve leaflets 700 of the mitral valve, and then move closer to each other to clamp and fix the valve leaflets 700. When the mitral valve clip 600 clamps the valve leaflets 700 in an inappropriate manner, the clip arms 620 and the clip arm linkage 630 move away from each other to release the valve leaflets 700, and then clamp the valve leaflets 700 again. Preferably, the clip arms 620 of the valve clip system of this embodiment include a first clip arm 621 and a second clip arm 622, and the first clip arm 621 and the second clip arm 622 are symmetrically arranged about the axis of the central base 610. Correspondingly, the clip arm linkage 630 of the valve clip system of this embodiment also includes a first clip arm linkage and a second clip arm linkage. The first clip arm linkage is used to cooperate with the first clip arm 621 to clamp one valve leaflet of the mitral valve, and the second clip arm linkage is used to cooperate with the second clip arm 622 to clamp the other valve leaflet of the mitral valve. In this embodiment, a detachable connection is adopted between the central base 610 and the distal end of the delivery device. For specific implementation manners, this embodiment does not limit this. For example, various coupling manners shown in the accompanying drawings of the specification and the relevant text in Chinese Patent Document CN102395331B, etc.

[0033] Furthermore, the mitral valve clip 600 further includes a braking assembly 640. The braking assembly 640 is used to drive the clip arms 620 to perform opening and closing movements around the central base 610 under the drive of the axial movement of the intermediate wire 200. The intermediate wire 200 moves axially towards the proximal end, and drives the first clip arm and the second clip arm to move closer to each other through the braking assembly. When the intermediate wire 200 moves axially towards the proximal end to a preset position, the first clip arm and the second clip arm are driven by the braking assembly to move closer to each other to a preset limit closing position, that is, the first position.

[0034] Please continue to refer to Figure 10a and Figure 10b , the braking assembly 640 of this embodiment includes a first link 641, a second link 642 and a base 643. One end of the first link 641 is rotatably connected to the first clip arm 621, and the other end is rotatably connected to the base 643; one end of the second link 642 is rotatably connected to the second clip arm 622, and the other end is rotatably connected to the base 643. The base 643 includes a horizontal portion and a vertical portion. The two ends of the horizontal portion are respectively connected to the first link 641 and the second link 642, and the vertical portion is received in the central base 610 and can move relative to the central base 610.

[0035] Specifically, the base 643 of this embodiment is in a "T" shape. The two ends of the horizontal part of the base 643 are respectively connected to the first connecting rod 641 and the second connecting rod 642. The vertical part is received in the central base 610 and can be movably connected to the central base 610. For example, the first connecting rod 641, the second connecting rod 642, the first clamping arm 621, the second clamping arm 622, the base 643, and the central base 610 form a connecting rod mechanism similar to a crank-slider mechanism by pin connection. Under the action of the force acting on the vertical part, the first clamping arm 621 and the second clamping arm 622 are rotated through the connecting rod mechanism to realize the clamping of the edge of the mitral valve leaflet.

[0036] In this embodiment, the moving assembly 100 further includes a driving member 120. The distal end of the driving member 120 is disposed in the inner cavity 410 of the housing 400, and the driving member 120 is configured to be rotatable only relative to the housing 400. The moving member 110 is configured to be axially movable only relative to the housing 400. And the moving member 110 is configured to be axially movable only relative to the housing 400, that is, the moving member 110 cannot rotate relative to the housing 400.

[0037] Please refer to Figures 3 to 5 specifically, the driving member 120 has an internal thread, and the moving member 110 has an external thread that is threadedly connected to the internal thread. The proximal end of the housing 400 is further provided with a proximal opening 420, and the proximal opening 420 is constricted to form an opening shoulder 421. The distal end of the driving member 120 is provided with an opening groove 121 extending circumferentially, and the opening shoulder 421 is received in the opening groove 121 so that the driving member 120 is restricted to rotate only relative to the housing 400.

[0038] On the other hand, a first restricting member is provided on the outer side of the distal end of the moving member 110, and a second restricting member is provided on the housing 400 at the corresponding position. The first restricting member and the second restricting member are configured to be axially movably connected along the housing 400 so that the moving member 110 is restricted to be axially movable only relative to the housing 400.

[0039] More specifically, the first restricting member is a limiting protrusion, and the second restricting member is a limiting groove. Among them, the limiting protrusion is arranged perpendicular to the axis of the housing 400, and both the limiting groove and the limiting protrusion extend along the axis of the housing 400. One end of the limiting protrusion is fixed to the outer periphery of the moving member 110, and the other end is received in the limiting groove. When the driving member 120 rotates, since the limiting protrusion is embedded in the limiting groove, the inner side wall of the limiting groove provided on the housing blocks the rotation of the limiting protrusion, thereby blocking the rotation of the moving member 110. In an alternative embodiment, the first restricting member is an axially arranged limiting groove, and the second restricting member is a limiting protrusion arranged perpendicular to the axis of the housing 400. One end of the limiting protrusion is fixed to the outer periphery of the housing 400, and the other end is received in the limiting groove.

[0040] In the present embodiment, when the driving member 120 rotates in the clockwise direction (observed from the left side to the right side of Figure 5 ), the moving member 110 moves proximally relative to the housing 400 under the drive of the driving member 120; when the driving member 120 rotates in the counterclockwise direction, the moving member 110 moves distally relative to the housing 400 under the drive of the driving member 120. Of course, in other alternative embodiments, when the driving member 120 rotates in the clockwise direction, the moving member 110 moves distally relative to the housing 400 under the drive of the driving member 120; when the driving member 120 rotates in the counterclockwise direction, the moving member 110 moves proximally relative to the housing 400 under the drive of the driving member 120.

[0041] In the present embodiment, the moving member 110 is generally cylindrical, the driving member 120 is tubular with a through hole, and the distal portion of the moving member 110 passes through the through hole of the driving member 120 and extends into the interior of the housing 410. Optionally, the driving member 120 can be cylindrical or polygonal prism-shaped.

[0042] Furthermore, as Figure 2 and Figure 4 shown, a limiting member 430 is further provided in the inner cavity 410 of the housing 400. The limiting member 430 is axially located at the distal end of the driving member 120. The limiting member 430 and the driving member 120 together form a space for accommodating the stroke positioning member 300. In fact, the limiting member 430 extends circumferentially along the inner side wall of the housing 400. The limiting member 430, the inner side wall of the housing 400, and the driving member 120 enclose a space, and the stroke positioning member 300 is located in this space. Preferably, the limiting member 430 is a baffle integrally formed with the housing 400.

[0043] In the present embodiment, the stroke positioning member 300 is annular. Further, the outer diameter of the stroke positioning member 300 is larger than the inner diameter of the housing 400 at the location where the stroke positioning member 300 is accommodated, so that the stroke positioning member 300 and the inner wall of the housing 400 are in interference fit. The interference fit between the stroke positioning member 300 and the housing 400, that is, the outer dimension of the stroke positioning member 300 in the direction perpendicular to the axis is larger than the inner dimension of the inner wall of the housing 400 in the direction perpendicular to the axis, can utilize the frictional force between the stroke positioning member 300 and the inner wall of the housing 400 to position the stroke positioning member 300 and prevent the stroke positioning member 300 from shifting.

[0044] Optionally, the stroke positioning member 300 can also be square annular, polygonal annular, etc. Optionally, the stroke positioning member 300 can be made of elastic materials such as silica gel and rubber, preferably natural rubber, butyl rubber or styrene-butadiene rubber. The stroke positioning member 300 can be one, two or more, and the specific number can be adjusted according to actual needs, and the embodiments of the present invention do not make specific limitations in this regard. When there are multiple stroke positioning members 300, the multiple stroke positioning members 300 are circumferentially arranged in the above-mentioned space.

[0045] Continue to refer to Figure 5 , in this embodiment, the stroke positioning member 300 is sleeved on the moving member 110. A pushing portion 111 is further provided at the distal end of the moving member 110 for pressing the stroke positioning member 300. The dimension of the pushing portion 111 in the direction perpendicular to the axis is matched with the dimension of the stroke positioning member 300 in the direction perpendicular to the axis. By matching the dimension of the pushing portion 111 in the direction perpendicular to the axis with the dimension of the stroke positioning member 300 in the direction perpendicular to the axis, it is ensured that the moving member 110 can contact and even press the stroke positioning member 300 when moving towards the proximal end. For example, the outer dimension of the pushing portion 111 in the direction perpendicular to the axis of the moving member 110 can be slightly larger than the inner dimension of the stroke positioning member 300 in the direction perpendicular to the axis of the moving member 110. That is, the distance from the outer contour of the pushing portion 111 to the axis of the housing 400 is greater than the distance from the inner contour of the stroke positioning member 300 to the axis of the housing 400.

[0046] Specifically, there are multiple pushing portions 111, and they are circumferentially arranged along the moving member 110. In this way, when the multiple pushing portions 111 contact the stroke positioning member 300, the multiple pushing portions 111 apply forces to the stroke positioning member 300 simultaneously, making the force on the stroke positioning member 300 more balanced. Further, there are also multiple limiting members 440, and they are circumferentially arranged along the housing 400. The multiple pushing portions 111 and the limiting members 440 are arranged at intervals in the circumferential direction so that the pushing portions 111 can pass through the limiting members 440 without interference between the two.

[0047] More specifically, the pushing portion 111 is a convex structure arranged on the surface of the moving member 110 in a direction perpendicular to the axis of the moving member 110, and is located at the distal end of the stroke positioning member 300. Optionally, the convex structure can be integrally formed with the moving member 110 or an independent structure fixedly connected to the moving member 110.

[0048] Further, a chute 440 extending along the axis of the outer shell 400 is provided on the wall surface of the inner cavity 410 of the outer shell 400. At least a part of the convex structure, for example, the part close to the inner wall of the shell 400, is received in the chute 440 and can move in the chute 440, so that the moving member 110 is restricted to move only axially relative to the outer shell 400. That is to say, when the chute 440 is provided on the inner side wall of the outer shell 400 and the interval between the chute 440 and the limiting member 440 corresponds, in this way, in addition to squeezing the stroke positioning member 300 under the drive of the driving member 120 to increase the stroke of the intermediate filament 200, the pushing portion 111 can also play the same role as the first limiting member, that is, restricting the rotation of the moving member 110. That is to say, if necessary, the structure of the moving member 110 can be simplified by omitting the first limiting member.

[0049] Preferably, the shape of the pushing portion 111 facing the stroke positioning member 300 matches the shape of the stroke positioning member 300. For example, when the cross-sectional shape of the stroke positioning member 300 is circular, the side wall of the pushing portion 111 facing the stroke positioning member 300 is provided as an arc-shaped side wall that coincides with the cross-sectional edge of the stroke positioning member 300. When the cross-section of the stroke positioning member 300 is other shapes, the side wall of the pushing portion 111 facing the stroke positioning member 300 can be correspondingly set as other shapes or parts of other shapes. This can enable better contact between the pushing portion 111 and the stroke positioning member 300.

[0050] In other embodiments, the interior of the outer shell 400 further includes a receiving member 450. The Rockwell hardness of the receiving member 450 is greater than that of the stroke positioning member 300. The receiving member 450 is clamped between the stroke positioning member 300 and the limiting member 440, and the pushing portion 111 squeezes the stroke positioning member 300 by pushing the receiving member 450. By providing the receiving member 450 between the stroke positioning member 300 and the limiting member 440, the pushing portion 111 applies pressure to the receiving member 450, and the receiving member 450 then applies pressure to the stroke positioning member 300. It can be understood that if the pushing portion 111 directly applies force to the stroke positioning member 300, only the part of the stroke positioning member 300 in contact with the pushing portion 111 will deform. After multiple uses, the stressed position of the stroke positioning member 300 may be damaged. By adding the receiving member 450, the receiving member 450 can squeeze the entire stroke positioning member 300 after being pushed by the pushing portion 111, enabling the stroke positioning member 300 to be stressed comprehensively and evenly, preventing the stroke positioning member 300 from being damaged. Moreover, the provision of the receiving member 450 facilitates the assembly of the conveying device.

[0051] Specifically, the receiving member 450 is annular. Preferably, the side wall of the receiving member 450 facing the stroke positioning member 300 is provided with a shape that coincides with the stroke positioning member 300. Optionally, the receiving member 450 is made of stainless steel, nitinol, aluminum alloy, etc.

[0052] In this embodiment, the conveying device further includes a wire clamping assembly 500, which is rotatably received in the moving assembly 100 and fixedly connected to the intermediate wire 200. The proximal end of the intermediate wire 200 is fixedly connected to the wire clamping assembly 500, and the distal end of the intermediate wire 200 is detachably connected to the prosthesis. Therefore, when the wire clamping assembly 500 is rotated, the mitral valve clip 600 can be separated from the intermediate wire 200. When the wire clamping assembly 500 moves axially along the housing 400, it can drive the intermediate wire 200 to move axially to open and close the clamping arms 620 of the mitral valve clip 600.

[0053] Please refer to Figure 6 and Figure 7 , the wire clamping assembly 500 includes a rotating shaft 510 and a handle 520 located at the proximal end of the rotating shaft 510. The handle 520 and the rotating shaft 510 are detachably connected. Specifically, the handle 520 includes a handle end at the proximal end and a first coupling end 522 at the distal end. The handle end is used for the operator to operate the rotation of the wire clamping assembly 500, and the first coupling end is used to couple with the rotating shaft 510 and clamp the intermediate wire 200. The handle 520 has a middle cavity 521 for receiving the intermediate wire 200. The rotating shaft 510 is generally cylindrical. The proximal end of the rotating shaft 510 has a second coupling end 513 for coupling with the first coupling end 522 to fix the intermediate wire 200. Exemplarily, the first coupling end 522 has an external thread, the second coupling end 513 has an internal thread, and a plurality of axially extending gaps are circumferentially spaced on the first coupling end 522. When the first coupling end 522 and the second coupling end 513 are threadedly connected, the gaps become smaller, and thus the middle cavity 521 becomes smaller to fix the proximal end of the intermediate wire 200. The rotating shaft 510 has a receiving cavity 511 for receiving the intermediate wire 200, and the middle cavity 521 and the receiving cavity 511 are communicated to provide a channel for the intermediate wire 200 to extend from the proximal end to the distal end.

[0054] Combined with Figure 8 , the moving member 110 has an axially penetrating channel. The proximal end of the handle 520 is disposed outside the proximal end of the moving member 110, and at least a part of the rotating shaft 510 is rotatably received in the channel. Thus, by driving the handle 520, the intermediate wire 200 can be driven to rotate relative to the moving member 110.

[0055] Further, the wire clamping assembly 500 further includes a one-way rotating member 530. The one-way rotating member 530 is located between the moving member 110 and the rotating shaft 510. The one-way rotating member 530 is configured to rotate the wire clamping assembly 500 in a first direction and prevent the wire clamping assembly 500 from rotating in a second direction, where the first direction and the second direction are opposite. Specifically, the one-way rotating member 530 of the present embodiment is disposed at the distal ends of the wire clamping assembly 500 and the moving member 110 to allow the wire clamping assembly 500 to rotate in the first direction but not in the second direction, preventing excessive coupling between the intermediate wire 200 and the mitral valve clip 600 that cannot be released. There is no particular limitation on the type of the one-way rotating member 530 in the present embodiment. Exemplarily, the one-way rotating member 530 can be a one-way bearing or a ratchet and pawl member.

[0056] Preferably, the one-way rotating member 530 of the present embodiment is a ratchet and pawl member. Specifically, the one-way rotating member 530 includes a ratchet and a pawl. Among them, the ratchet is disposed at the distal end of the rotating shaft 510, and the pawl is configured to be fixed at the distal end of the moving member 110. Through the cooperation of the ratchet and the pawl, the wire clamping assembly 500 rotates relative to the moving member 110 in the first direction and cannot rotate in the direction opposite to the first direction, that is, the second direction.

[0057] Please refer to again Figure 5 、 Figure 7 and Figure 8 again, the wire clamping assembly 500 further includes a positioning pin 540. The moving member 110 is provided with a first positioning through slot 112, and the outer wall of the rotating shaft 510 is provided with a second positioning through slot 512. The cross-sectional shape of the first positioning through slot 112 and the cross-sectional shape of the second positioning through slot 512 are configured to cooperate with each other to form a closed shape, so that the first positioning through slot 112 and the second positioning through slot 512 after cooperation form a positioning through hole 550. The positioning pin 540 is inserted through the positioning through hole 550 to prevent relative movement between the moving member 110 and the rotating shaft 510. Specifically, after the first positioning through slot 112 and the second positioning through slot 512 are aligned and matched to form a positioning through hole 550, the positioning pin 540 abuts against the inner side wall of the first positioning through slot 112 and the inner side wall of the second positioning through slot 512 after extending into the positioning through hole 550, thereby relatively fixing the moving member 110 and the rotating shaft 510. Only when the moving member 110 moves, the rotating shaft 510 will follow the movement, and at the same time, the rotating shaft 510 cannot rotate, which can avoid premature unwinding of the prosthesis due to misoperation during the delivery of the prosthesis.

[0058] The second embodiment of the present invention provides a medical system, as Figures 1 to 8 shown, including a prosthesis and the delivery device described in the above first embodiment, and the distal end of the intermediate wire 200 of the delivery device is detachably connected to the prosthesis.

[0059] Specifically, the prosthesis is a valve clip for clamping the edge of the native leaflet, such as the mitral valve clip described in the above embodiments. It can be understood that the prosthesis can also be other types of implantable prostheses.

[0060] The delivery device and medical system provided by the embodiments of the present invention have been introduced in detail above. Specific examples are used in this article to elaborate on the principles and embodiments of the present invention. The descriptions of the above embodiments are only used to help understand the idea of the present invention, and there will be changes in the specific embodiments and application scopes. In summary, the content of this specification should not be construed as a limitation on the present invention.

Claims

1. A delivery device for a prosthesis, characterized in that, it includes: a moving component, an intermediate wire, a stroke positioning member, and a housing; the housing includes an inner cavity; the moving component includes a moving member, the distal end of the moving member is disposed in the inner cavity of the housing, the moving member can move relative to the housing along the axial direction of the housing, and the moving member is used to drive the prosthesis to move by driving the axial movement of the intermediate wire; the stroke positioning member has elasticity and is accommodated in the inner cavity of the housing; the stroke positioning member is configured such that when the moving member moves to a preset position and the prosthesis moves to a first position, the stroke positioning member abuts against the moving member to prevent the moving member from continuing to move; when the moving member moves to the preset position while the prosthesis does not move to the first position, the moving member overcomes the elastic force generated by the elastic deformation of the stroke positioning member and continues to move so that the prosthesis moves to the first position.

2. The delivery device according to claim 1, characterized in that, the moving component further includes a driving member, the distal end of the driving member is disposed in the inner cavity of the housing, and the driving member is configured to be rotatable only relative to the housing, and the moving member is configured to be axially movable only relative to the housing.

3. The delivery device according to claim 2, characterized in that, the driving member has an internal thread, and the moving member has an external thread that is threadedly connected to the internal thread; a proximal opening is further provided at the proximal end of the housing, and the proximal opening is constricted to form an opening shoulder; a circumferentially extending opening groove is provided at the distal end of the driving member, and the opening shoulder is accommodated in the opening groove so that the driving member is restricted to be rotatable only relative to the housing; a first restricting member is provided on the outer side of the distal end of the moving member, and a second restricting member is provided on the housing at the corresponding position, and the first restricting member and the second restricting member are configured to be axially movably connected along the axial direction of the housing so that the moving member is restricted to be axially movable only relative to the housing.

4. The delivery device according to claim 2, characterized in that, a limiting member is further provided in the inner cavity of the housing, the limiting member is axially located at the distal end of the driving member, and the limiting member and the driving member together form a space for accommodating the stroke positioning member.

5. The delivery device according to claim 4, characterized in that, the stroke positioning member is sleeved on the moving member; a pushing portion is further provided at the distal end of the moving member, and the dimension of the pushing portion in the direction perpendicular to the axis matches the dimension of the stroke positioning member in the direction perpendicular to the axis for squeezing the stroke positioning member.

6. The delivery device according to claim 5, characterized in that, the pushing portions are multiple and are arranged circumferentially along the moving member; the limiting members are also multiple and are arranged circumferentially along the housing; the multiple pushing portions and the limiting members are circumferentially spaced apart so that the pushing portions can pass through the limiting members.

7. The delivery device according to claim 5 or 6, characterized in that, The pushing part is a convex structure arranged on the surface of the moving part and extending perpendicular to the axis direction of the moving part, and the convex structure is located at the distal end of the stroke positioning part.

8. The conveying device according to claim 7, wherein, a chute extending along the axial direction of the outer shell is arranged on the wall surface of the inner cavity of the outer shell, at least part of the convex structure is accommodated in the chute, and can move in the chute, so that the moving part is restricted and can only move relative to the outer shell.

9. The conveying device according to claim 5, wherein, the stroke positioning part is annular.

10. The conveying device according to claim 9, wherein, the outer diameter of the stroke positioning part is larger than the inner diameter of the outer shell at the position where the stroke positioning part is accommodated, so that the stroke positioning part and the inner wall of the outer shell are in interference fit.

11. The conveying device according to claim 9, wherein, it further includes a receiving part, the receiving part is clamped between the stroke positioning part and the limiting part, the Rockwell hardness of the receiving part is greater than the Rockwell hardness of the stroke positioning part, and the pushing part squeezes the stroke positioning part by pushing the receiving part.

12. The conveying device according to claim 9, wherein, the shape of the side of the pushing part facing the stroke positioning part matches the shape of the stroke positioning part.

13. The conveying device according to claim 2, wherein, it further includes a wire clamping assembly, the wire clamping assembly is rotatably accommodated in the moving assembly and is fixedly connected with the intermediate wire; the moving part has an axially penetrating channel, at least part of the wire clamping assembly is rotatably accommodated in the channel, and the wire clamping assembly drives the prosthesis to rotate via the intermediate wire.

14. The conveying device according to claim 13, wherein, the wire clamping assembly includes a rotating shaft and a handle located at the proximal end of the rotating shaft, the handle has a middle cavity for accommodating the intermediate wire, the rotating shaft has an accommodating cavity for accommodating the intermediate wire, and the middle cavity and the accommodating cavity are communicated; the handle is coupled with the rotating shaft to fix the intermediate wire.

15. The conveying device according to claim 14, wherein, the wire clamping assembly further includes a one-way rotating part, the one-way rotating part is located between the moving part and the rotating shaft, and the one-way rotating part is used to make the wire clamping assembly rotate in a first direction and prevent the wire clamping assembly from rotating in a second direction, and the first direction and the second direction are opposite.

16. The conveying device according to claim 14, wherein, the wire clamping assembly further includes a positioning pin; the moving part is provided with a first positioning through groove, the outer wall of the rotating shaft is provided with a second positioning through groove, the cross-sectional shape of the first positioning through groove and the cross-sectional shape of the second positioning through groove are configured to cooperate with each other to form a closed shape, so that the first positioning through groove and the second positioning through groove after cooperation form a positioning through hole; the positioning pin penetrates through the positioning through hole to prevent relative movement between the moving part and the rotating shaft.

17. A medical system, wherein, Comprising a prosthesis and a delivery device as described in any one of claims 1-16, the distal end of the intermediate filament of the delivery device is detachably connected to the prosthesis.

18. The medical system according to claim 17, wherein, the prosthesis is a valve clip for clamping the edge of the native valve leaflet.

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