A herbicide composition containing sulfonepyraclostrobin, thifensulfuron-methyl and saflufenacil and its application

Abstract

The present invention discloses a herbicide composition containing sulfometrazoline, thifensulfuron-methyl, and saflufenacil, and its use. The composition comprises sulfometrazoline, thifensulfuron-methyl, and saflufenacil, wherein the weight ratio of sulfometrazoline: thifensulfuron-methyl: saflufenacil is 10:1:0.5-2. The herbicide combination provided by the present invention combines the highly active herbicide sulfometrazoline with thifensulfuron-methyl and saflufenacil for the first time, achieving synergistic weed control, significantly reducing the dosage of pesticides used, lowering the cost of pesticides, and reducing the adverse impact of pesticides on the environment.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticide compositions, and particularly relates to a herbicide composition containing pyrasulfotole, thifensulfuron-methyl and saflufenacil, and application thereof. Background Art

[0002] With years of continuous herbicide use, weed resistance has increased, particularly to post-emergence foliar herbicides. Farmers are increasing dosages to achieve greater control, which increases both planting costs and potential environmental risks. Developing highly effective, low-residue, broad-spectrum herbicide formulations is an effective solution to address weed resistance in farmland and a viable measure to achieve society's goal of reducing pesticide and fertilizer use and increasing efficiency.

[0003] Pyroxasulfone: Its common name is pyroxasulfone, and its chemical name is 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-isoxazole. It is suitable for pre-emergence control of grass weeds such as multiflora ryegrass, sedge grass, foxtail grass, crabgrass, and foxtail grass, as well as some broadleaf weeds in wheat, corn, soybeans, and peanuts. The active ingredient dosage is 75-150 grams per hectare, about one-tenth the dosage of acetochlor. According to the "World Pesticide Encyclopedia: Herbicides, Second Edition," pyroxasulfone has a soil half-life (DT50) of over 142 days, indicating a long-lasting effect. The International Herbicide Resistance Action Committee (HRAC) classifies it as a K3 herbicide.

[0004] Thifensulfuron-methyl: Its common name is thifensulfuron-methyl, and its chemical name is 3-(4-methoxy-6-methyl-1,3,5-triazin-2-ylaminocarbonylaminosulfonyl)thiophene-2-carboxylic acid methyl ester. It is primarily used for pre-emergence control of various annual and perennial broadleaf weeds in crops such as cereals, soybeans, and corn. The active ingredient dosage is 15-30 grams per hectare, about 1 / 50 of that of atrazine. According to data from The Pesticide Manual, thifensulfuron-methyl has a soil half-life (DT50) of up to 7 days and a DT90 of up to 50 days. The International Herbicide Resistance Action Committee (HRAC) classifies it as a Category B herbicide.

[0005] Saflufenacil: Its common name is saflufenacil, and its chemical name is N′-{2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)pyrimidin-1(2H)-yl]-4-fluorobenzoyl}-N-isopropyl-N-methylsulfonamide. It is primarily used in soybean, wheat, corn, and orchards for pre- and post-emergence control of over 100 annual broadleaf weeds, including Solanum nigrum, Erigeron candidum, Galium scabra, Sophora flavescens, Aglaonema truncatum, and Abutilon. The active ingredient dosage per hectare is 15-60 grams, approximately 1 / 50 to 1 / 25 of that of atrazine. According to The Pesticide Manual, saflufenacil has a soil half-life (DT50) of approximately 15 days.

[0006] At present, there are no reports on the combination of sulfamethoxam, thifensulfuron-methyl and saflufenacil, and there is no report on the combination of sulfamethoxam to solve the problem of low efficiency in removing highly resistant grasses and malignant broadleaf and sedge weeds that are difficult to control in farmland. Summary of the Invention

[0007] The purpose of this section is to summarize some aspects of the embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the abstract and title of this application to avoid obscuring the purpose of this section, the abstract and the title of the invention, and such simplifications or omissions should not be used to limit the scope of the present invention.

[0008] In view of the above problems and / or the problems existing in the prior art, the present invention is proposed.

[0009] Therefore, the object of the present invention is to overcome the deficiencies in the prior art and provide a herbicide composition containing sulfonepyraclostrobin, thifensulfuron-methyl and saflufenacil.

[0010] To solve the above technical problems, the present invention provides the following technical solution: a herbicide composition containing sulfonepyraclostrobin, thifensulfuron-methyl and saflufenacil, including sulfonepyraclostrobin, thifensulfuron-methyl and saflufenacil, wherein, according to the weight ratio, sulfonepyraclostrobin: thifensulfuron-methyl: saflufenacil = 10:1:0.5~2.

[0011] As a preferred embodiment of the composition of the present invention, the weight ratio of sulfonepyraclostrobin: thifensulfuron-methyl: saflufenacil is 10:1:1.

[0012] As a preferred embodiment of the composition of the present invention, the herbicide composition further comprises a surfactant and an auxiliary carrier that are acceptable in pesticides.

[0013] As a preferred embodiment of the composition of the present invention, the pesticide-acceptable surfactant includes castor oil polyoxyethylene ether, calcium dodecylbenzenesulfonate, dichloropropyleneamine, polymeric carboxylates, and sodium lauryl sulfate.

[0014] As a preferred embodiment of the composition of the present invention, the auxiliary carrier includes white carbon black, organic bentonite, ethyl acetate, solvent oil S-150#, methyl oleate, ammonium sulfate, and diatomaceous earth.

[0015] As a preferred embodiment of the composition of the present invention, in the composition, the total mass percentage of sulfamethoxazole, thifensulfuron-methyl and saflufenacil accounts for 11.5% to 78% of the total mass of the composition, and the rest is pesticide-acceptable surfactants and auxiliary carriers.

[0016] As a preferred embodiment of the composition of the present invention, the herbicide composition dosage forms include suspension concentrates, dispersible oil suspension concentrates, wettable powders, water-dispersible granules, and dry suspension concentrates.

[0017] Another object of the present invention is to overcome the deficiencies in the prior art and provide an application of the herbicide composition, which is used for closed weeding of wheat, corn, soybean, peanut crops and corn-soybean and corn-peanut composite planting cultivation patterns.

[0018] Beneficial effects of the present invention:

[0019] (1) The herbicide combination provided by the present invention is the first to combine the highly active herbicide sulfonepyraclostrobin with thifensulfuron-methyl and saflufenacil, which has a synergistic weed-killing effect, significantly reduces the dosage of pesticides used, reduces the cost of pesticides, and reduces the adverse effects of pesticides on the environment;

[0020] (2) The herbicide combination provided by the present invention has different mechanisms of action and complementary herbicidal spectra, and has ideal effects on difficult-to-control plants such as multiflora ryegrass and nightshade;

[0021] (3) The herbicide combination provided by the present invention is highly safe for wheat, corn, soybeans, and peanuts, and can solve the problem of lack of herbicide options in corn-soybean and corn-peanut composite planting. DETAILED DESCRIPTION

[0022] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the embodiments of the specification.

[0023] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0024] Secondly, the term "one embodiment" or "embodiment" herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in various places throughout this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive of other embodiments.

[0025] An embodiment of the present invention provides a herbicide composition comprising the following ingredients: sulfamethoxam, thifensulfuron-methyl and saflufenacil; the herbicide composition may contain pesticide-acceptable herbicide safeners such as isoxadiazine, cyproconazole, fenpyroximate, mefenpyraclostrobin, furazolidone and dichloropropane.

[0026] The herbicide combination of the embodiment of the present invention is added with a suitable pesticide adjuvant and processed into a dosage form suitable for agricultural use, such as a dispersible suspension concentrate, a suspension concentrate, a wettable powder, or a water-dispersible granule, according to methods known to those skilled in the art.

[0027] The production processes of various formulations of the herbicide combination provided by the present invention are all known technologies and will not be described in detail here.

[0028] The herbicidal combination provided by the present invention is usually used by spraying with water, and other agricultural application techniques can also be used as needed. The herbicidal combination provided by the present invention should be used after crop sowing and before weeds emerge.

[0029] Example 1

[0030] (1) 30% sulfamethoxazole, thifensulfuron-methyl, and benzylpyrasulfuron dispersible oil suspension:

[0031]

[0032] (2) Preparation method of dispersed oil suspension

[0033] Mix sulfone metabendazole, thifensulfuron-methyl, saflufenacil, surfactants and excipients in a preparation kettle, shear for 20 to 30 minutes until uniform, and grind them coarsely in a sand mill. Use cooling brine to cool the grinding process and control the temperature within 30°C.

[0034] The coarsely ground mixture is finely ground, and the particle size after grinding is controlled to be below 15 μm.

[0035] Example 2

[0036] (1) 72% sulfamethoxazole, thifensulfuron-methyl, and saflufenacil water dispersible granules:

[0037]

[0038] (2) Preparation method of water dispersible granules

[0039] The sulfone metabendazole, thifensulfuron-methyl, saflufenacil, surfactant and auxiliary materials are added into a double cone mixer and mixed evenly, then crushed into particles with a jet mill to a size of 7 to 18 μm, then added into the double cone mixer, kneaded with water, and granulated to obtain the water dispersible granules.

[0040] Example 3

[0041] Colby method for determining the combined effect of the composition: The herbicidal effect of the three components was evaluated by measuring the survival rate and combined effect of the composition on grass and broadleaf weeds.

[0042] The specific implementation is as follows:

[0043] The examples are based on NY / T 1155.3-2006, "Guidelines for Indoor Bioassay Tests of Pesticides—Herbicides—Part 3: Activity Determination—Soil Spray Method," and NY / T 1155.7-2006, "Guidelines for Indoor Bioassay Tests of Pesticides—Herbicides—Part 7: Determination of Combined Actions of Mixtures." Indoor toxicity tests were performed to demonstrate the combined effects of sulfamethoxazole, thifensulfuron-methyl, and saflufenacil against common grass and broadleaf weeds in farmland.

[0044] Preparation of test agents: 97% sulfamethoxazole technical, 98% thifensulfuron technical, and 97% saflufenacil technical were dissolved in appropriate amounts of acetone, and then prepared with 0.1% surfactant (Tween 80: Span 20 = 2:1) aqueous solution to the required concentration for use.

[0045] Experimental method: The experiment adopted the greenhouse potting method. The seeds of Solanum nigrum L., Eclipta prostrata (L.) L., Lolium multiflorum Lamk., and Digitaria sanguinalis (L.) Scop. were germinated and sown in small flower pots filled with 3 / 5 culture soil. 8×8 seeds were sown in each pot and covered with 1-2mm of soil after sowing.

[0046] Add water to the tray containing the small flower pots. After the water completely soaks the culture soil, pour out the excess water in the tray.

[0047] 24 hours after sowing, the soil was sprayed with an ASS-5 walking spray tower, and clean water was set as a blank control. The plants were then transferred to the greenhouse for further cultivation and observation. After 20 days, the aboveground fresh weight of the weeds in each treatment was investigated.

[0048] Except for 1 to 2 days after spraying, water regularly to maintain soil moisture.

[0049] Weed survival rate calculation method:

[0050]

[0051] The herbicidal activity of the mixture was tested using the Colby method, i.e., E0 = ABC / 10000; where A is the weed survival rate of a single dose of the herbicide (pyraclostrobin), B is the weed survival rate of a single dose of the herbicide (thifensulfuron-methyl), C is the weed survival rate of a single dose of the herbicide (safensulfuron-methyl), E0 is the theoretical survival rate of the mixed herbicide, and E is the measured survival rate of the mixed herbicide.

[0052] According to the Colby method, when E0-E ≥ 10%, it indicates that the mixed herbicide produces a synergistic effect; when E0-E ≤ -10%, it indicates that the mixed herbicide produces an antagonistic effect; when the E0-E value is between ±10%, it indicates that the mixed herbicide produces an additive effect.

[0053] The indoor survival rates of the combination of sulfamethoxam, thifensulfuron-methyl and saflufenacil on the target weeds and their combined crops are shown in the following table.

[0054] Table 1 Results of test on survival rate of Solanum nigrum treated by various agents and evaluation of their combined effects

[0055]

[0056]

[0057] Table 2 Results of the test on the survival rate of the intestine and the evaluation of the combined effects of each drug treatment

[0058]

[0059] Table 3 Results of test on survival rate of Lolium multiflorum and evaluation of combined effects of each pesticide treatment

[0060]

[0061] Table 4 Survival rate test and combined effect evaluation results of each drug treatment on crabgrass

[0062]

[0063]

[0064] Analysis of application test 1 results:

[0065] The results in Table 1 show that the combination of sulfonepyrazone + thifensulfuron-methyl + saflufenacil showed a synergistic effect on the test weed Solanum nigrum at the following dosages: 60+6+6, 60+6+9, 60+6+12, 90+9+6, 90+9+9, 90+9+12, 120+12+6, 120+12+9, and 120+12+12; the other dosage groups all showed an additive effect; correspondingly, sulfonepyrazone + thifensulfuron-methyl + saflufenacil showed a synergistic effect on the test weed Solanum nigrum at the following dosages: 60+6+6, 60+6+9, 60+6+12, 90+9+6, 90+9+9, 90+9+12, 120+12+6, 120+12+9, and 120+12+12. The ratios of oxadiazole:thifensulfuron-methyl:safensulfuron are 10:1:0.5, 10:1:0.67, 10:1:0.75, 10:1:1, 10:1:1.33, 10:1:1.5, and 10:1:2. It is speculated that when the ratio of oxadiazole:thifensulfuron-methyl:safensulfuron is 10:1:0.5 to 2, the combination exhibits a significant synergistic effect on the broad-leaved weed Solanum nigrum, while other ratios exhibit an additive effect.

[0066] The results in Table 2 show that the combination of sulfonepyrazone + thifensulfuron-methyl + saflufenacil showed synergistic effects on the test weeds at the following dosages: 60+6+6, 60+6+9, 60+6+12, 90+9+6, 90+9+9, 90+9+12, 120+12+6, 120+12+9, and 120+12+12; the other dosage groups showed additive effects; correspondingly, sulfonepyrazone + thifensulfuron-methyl + saflufenacil showed synergistic effects on the test weeds at the following dosages: 60+6+6, 60+6+9, 60+6+12, 90+9+6, 90+9+9, 90+9+12, 120+12+6, 120+12+9, and 120+12+12. The ratios of oxadiazole:thifensulfuron-methyl:safensulfuron were 10:1:0.5, 10:1:0.67, 10:1:0.75, 10:1:1, 10:1:1.33, 10:1:1.5, and 10:1:2. It is speculated that when the ratio of oxadiazole:thifensulfuron-methyl:safensulfuron is 10:1:0.5-2, the combination exhibits a significant synergistic effect on broadleaf weeds, while other ratios exhibit an additive effect.

[0067] The results in Tables 3 and 4 show that the combination of sulfamethoxazole, thifensulfuron-methyl, and safensulfuron-methyl exhibited an additive effect on both the tested multifloral ryegrass and crabgrass under the tested ratio conditions. This result is related to the herbicidal spectrum of safensulfuron and thifensulfuron-methyl. Safensulfuron and thifensulfuron-methyl primarily control broadleaf or sedge weeds and have only partial inhibitory effects on grass weeds such as multifloral ryegrass and crabgrass.

[0068] When the ratio of sulfonepyraclostrobin: thifensulfuron-methyl: saflufenacil is 10:1:0.5-2, a synergistic effect is exhibited on broad-leaved weeds; preferably, when the ratio of sulfonepyraclostrobin: thifensulfuron-methyl: saflufenacil is 10:1:1, the E0-E value is the largest, and the synergistic effect on the broad-leaved weeds Solanum nigrum and Ligusticum chuanxiong is more obvious; there is no antagonistic effect on the tested grass weeds Perennial ryegrass and Digitaria sanguinea.

[0069] Example 4

[0070] The selectivity index of the composition of Example 1 was determined (with barnyard grass and quinoa as test weeds, and wheat, corn, soybean, and peanut as test crops). The specific determination method is as follows:

[0071] The experiment used a greenhouse potting method. Wheat, corn, soybean, and peanut seeds were germinated and sown in small pots filled with 3 / 5 potting soil, with 3 seeds per pot. Barnyardgrass and quinoa seeds were germinated and sown in small pots filled with 3 / 5 potting soil, with 8 seeds per pot. After sowing, the seeds were covered with 1-2 mm of soil. Water was added to the tray containing the small pots. Once the water completely soaked the soil, the excess water in the tray was discarded.

[0072] 24 hours after sowing, the soil was sprayed with an ASS-5 walking spray tower, and clean water was set as a blank control. The plants were then transferred to the greenhouse for further cultivation and observation. After 30 days, the plant heights of wheat, corn, soybeans, and peanuts, as well as the aboveground fresh weights of the weeds in each treatment were investigated.

[0073] Except for 1 to 2 days after spraying, water regularly to maintain soil moisture.

[0074] Weed control effectiveness calculation method:

[0075]

[0076] The lowest effective dose of the pesticide on the main sensitive weeds 90 The highest safe dose (ED) when the herbicide inhibits the plant height of the applied crop by no more than 10% is used as the evaluation index of herbicide activity. 10 (NOEL) is a crop safety evaluation index.

[0077] Selectivity coefficient I = ED 10 / ED 90 ;

[0078] When I ≥ 4, the agent is considered to have excellent selectivity and good value for field promotion;

[0079] When I ≥ 2, the agent is considered to have certain selectivity and can be used for field trials;

[0080] When I<2, the agent is considered to have poor selectivity and no development potential.

[0081] Wheat, corn, soybean, and peanut were used as test crops, and barnyard grass and quinoa were used as test target weeds. The selectivity index was determined as shown in the following table:

[0082] Table 5 Determination results of the selectivity index of 30% sulfonepyraclostrobin·thifensulfuron-methyl·safensulfuron OD on the test crops and barnyard grass

[0083]

[0084] Table 6 Determination results of the selectivity index of 30% sulfonepyraclostrobin·thifensulfuron-methyl·safensulfuron OD on the test crops and Chenopodium album

[0085]

[0086] analyze:

[0087] The results in Table 5 show that the selectivity index I of 30% sulfonepyraclostrobin·thifensulfuron-methyl·safensulfuron OD between the test crops wheat, corn, soybean, peanut and the weed barnyard grass is 13.22, 13.83, 9.92 and 5.36, respectively, indicating that the composition of Example 1 has excellent selectivity between the test crops and the weed barnyard grass;

[0088] The results in Table 6 show that the selectivity index I of 30% sulfonepyraclostrobin·thifensulfuron-methyl·safensulfuron OD between the test crops wheat, corn, soybean, peanut and the weed Chenopodium quinoa is 13.56, 14.18, 10.17 and 5.50, respectively, indicating that the composition of Example 1 has excellent selectivity between the test crops and the weed Chenopodium quinoa.

[0089] The composition is highly safe for wheat, corn, soybeans, and peanuts, has excellent weed control effects, and has a lasting effect of more than 30 days. It can be used to control common grass and broad-leaved weeds on the above crops, and can be used for corn-soybean and corn-peanut composite planting cultivation, solving the problem of lack of drug options in composite planting models.

[0090] Comparative Example 1

[0091] This comparative example is used to explore the effects of herbicide combinations on weed survival rate (herbicidal effect) and crop safety. Specifically:

[0092] The active ingredients of the adjusted herbicides are:

[0093] a1: sulfone metabendazole + thifensulfuron-methyl + saflufenacil = 25% + 5% + 0%;

[0094] b1: sulfone metabendazole + thifensulfuron-methyl + saflufenacil = 25% + 0% + 5%;

[0095] c1: sulfonepyraclostrobin + thifensulfuron-methyl + saflufenacil = 30% + 0% + 0%; other proportions are the same as in Example 1.

[0096] The indoor safety and control efficacy were compared with the composition of Example 1 (sulfone metabendazole: thifensulfuron-methyl: saflufenacil = 25 + 2.5 + 2.5);

[0097] After each group of original drugs were dissolved in acetone, they were prepared into test solutions with a 0.1% surfactant (Tween 80: Span 20 = 2:1) aqueous solution. The dosage concentration was 180 g·i / ha. The results were compared with the dosage concentration of 180 g·i / ha in Example 1. The results are shown in Table 7 below.

[0098] Table 7

[0099]

[0100]

[0101] In the comparative examples, at a dosage concentration of 180 g ai / ha, the plant height inhibition rates of compounds a1, b1, and c1 on peanuts, soybeans, corn, and wheat decreased in descending order, and were higher than those in Example 1. In particular, compound a1 achieved a plant height inhibition rate of >10% on soybeans and peanuts, exceeding the acceptable safety range. This indicates that the composition ratio not only affects herbicidal efficacy but also significantly impacts crop safety. Based on the efficacy and safety data, the compositions of the present invention exhibit ideal comprehensive weed control efficacy and safety.

[0102] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, and all of these should be included in the scope of the present invention.

Claims

1. A herbicide composition containing sulfonepyraclostrobin, thifensulfuron-methyl and saflufenacil, characterized in that: The invention comprises sulfonepyraclostrobin, thifensulfuron-methyl and saflufenacil, wherein the weight ratio of sulfonepyraclostrobin: thifensulfuron-methyl: saflufenacil is 10:1:0.5-2.

2. The composition according to claim 1, wherein: Calculated by weight, sulfamethoxazole: thifensulfuron-methyl: saflufenacil = 10:1:

1.

3. The composition according to claim 1 or 2, wherein: The herbicide composition further comprises a pesticide-acceptable surfactant and an auxiliary carrier.

4. The composition according to claim 3, wherein: The pesticide-acceptable surfactant includes castor oil polyoxyethylene ether, calcium dodecylbenzenesulfonate, dichloropropyleneamine, polymeric carboxylates, and sodium lauryl sulfate.

5. The composition according to claim 3, wherein: The auxiliary carrier includes white carbon black, organic bentonite, ethyl acetate, solvent oil S-150#, methyl oleate, ammonium sulfate and diatomaceous earth.

6. The composition according to any one of claims 1, 2, 4 and 5, wherein: In the composition, the total mass percentage of sulfamethoxazole, thifensulfuron-methyl and saflufenacil accounts for 11.5% to 78% of the total mass of the composition, and the remainder is a surfactant and an auxiliary carrier acceptable in pesticide science.

7. The composition according to claim 1, wherein: The herbicide composition dosage forms include suspension concentrate, dispersible oil suspension concentrate, wettable powder and water dispersible granules.

8. Use of the herbicide composition according to any one of claims 1 to 7, characterized in that: The composition is used for closed weeding of wheat, corn, soybean, peanut crops and corn-soybean and corn-peanut composite planting cultivation modes.

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