A pesticide composition containing a mesoionic compound and use thereof

Abstract

The application belongs to the technical field of pesticide insecticide, and discloses a pesticide composition containing mesoionic compounds and application thereof. The pesticide composition comprises active ingredient A and active ingredient B. The active ingredient A is isoflualanam, the active ingredient B is a mesoionic compound, the mesoionic compound is any one of triflumin, dicloromezotiaz and fenmezoditiaz, and the mass ratio of the active ingredient A to the active ingredient B is 1:40-40:1. The pesticide composition has a significant synergistic effect on the hemipteran pest rice planthopper, greatly improves the control effect, slows down the development of pest resistance and reduces the production cost.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of pesticide insecticide, and discloses a pesticide composition containing a mesoionic compound and application thereof. BACKGROUND

[0002] Rice is widely planted in China and is one of the main economic sources of local farmers in some areas. There are many factors affecting the yield and quality of rice, including pests such as rice leaf roller and rice planthopper. The current rice planthopper in China includes brown planthopper, gray planthopper and white-backed planthopper. Rice planthopper sucks the juice of rice leaves, affects nutrient and water transport, causes plant growth to be short and slow, and even wilting and death. While sucking the juice, the pests also secrete solid saliva to form a stylet sheath, and the leaf wound is difficult to heal, affecting tissue activity, causing the rice leaves to lose water and turn yellow, and the base to rot, making the rice plant lodge and die. Rice planthopper can carry the tooth leaf stunt disease or grassy stunt disease virus, and the excreted feces can also cause the smoke coal disease, which seriously affects the healthy growth of rice.

[0003] For many years, the main choice of rice planthopper control agents is thiazide, imidacloprid, in addition to which there are carbamate, nicotine and other agents. However, long-term and large-scale use has led to an increasing resistance of rice planthoppers, and the degree of occurrence has also increased year by year. The increased resistance further leads to a substantial increase in the amount of pesticide used, an increase in the cost of control, and an unsatisfactory control effect, causing many problems, and it is very urgent to popularize a new type of rice planthopper-killing pesticide composition. SUMMARY

[0004] Based on the problems existing in the prior art, the present application provides a pesticide composition containing a mesoionic compound, which has a significant synergistic effect on the hemipteran pest rice planthopper, can effectively delay the development of pest resistance, reduce the amount of pesticide used, and reduce production costs.

[0005] In order to achieve the above purpose, the present application adopts the following technical scheme: a pesticide composition containing a mesoionic compound, the active ingredient of the pesticide composition comprising active ingredient A and active ingredient B, the active ingredient A being isoflualanam, the active ingredient B being a mesoionic compound, the mesoionic compound being any one of triflumizole, dicloromezotiaz or fenmezoditiaz, and the mass ratio of the active ingredient A to the active ingredient B being 1:40-40:1.

[0006] Further, the active ingredient B is triflumizole, and the mass ratio of the active ingredient A to the active ingredient B is 1:30-40:1.

[0007] The active ingredient B is dicloromezotiaz, and the mass ratio of the active ingredient A to the active ingredient B is 1:30-20:1.

[0008] The active ingredient B is fenmezoditiaz, and the mass ratio of the active ingredient A to the active ingredient B is 1:40-25:1.

[0009] Further, the active ingredient B is triflubri-mid, and the mass ratio of the active ingredient A to the active ingredient B is 1:16-35:1.

[0010] The active ingredient B is dicloromezotiaz, and the mass ratio of the active ingredient A to the active ingredient B is 1:30-15:1.

[0011] The active ingredient B is fenmezoditiaz, and the mass ratio of the active ingredient A to the active ingredient B is 1:30-18:1.

[0012] Further, the active ingredient B is triflubri-mid, and the mass ratio of the active ingredient A to the active ingredient B is 1:8-25:1.

[0013] The active ingredient B is dicloromezotiaz, and the mass ratio of the active ingredient A to the active ingredient B is 1:20-15:1.

[0014] The active ingredient B is fenmezoditiaz, and the mass ratio of the active ingredient A to the active ingredient B is 1:18-18:1.

[0015] Further, the total content of the active ingredient A and the active ingredient B in the pesticide composition is 0.5-80wt% based on the total weight of the pesticide composition.

[0016] Further, the pesticide composition comprises an auxiliary agent in addition to the active ingredients, and the auxiliary agent is selected from one or more of wetting agents, dispersants, emulsifiers, thickening agents, disintegrants, antifreezing agents, antifoaming agents, solvents, preservatives, stabilizers, synergists or carriers.

[0017] The wetting agent is selected from one or more of alkyl benzene sulfonate, alkyl naphthalene sulfonate, lignin sulfonate, sodium dodecyl sulfate, dioctyl phthalate sulfonate sodium, alpha-olefin sulfonate, alkyl phenol polyoxyethylene ether, castor oil polyoxyethylene ether, alkyl phenol ethoxylate, fatty alcohol ethoxylate, fatty alcohol polyoxyethylene ether sodium sulfate, silkworm excrement, soap nut powder, soapberry powder, SOPA, detergent, emulsifier 2000 series and wetting penetrant F; and / or

[0018] The dispersant is selected from one or more of lignin sulfonate, alkyl naphthalene sulfonate formaldehyde condensate, naphthalene sulfonate, styrene-based phenol ethoxylate phosphate, fatty alcohol ethoxylate, alkyl phenol polyoxyethylene, alkyl phenol polyoxyethylene formalin ether condensate sulfate, fatty amine polyoxyethylene, glycerin fatty acid ester polyoxyethylene, polycarboxylate, polyacrylate, phosphate, EO-PO block copolymer, and EO-PO graft copolymer; and / or

[0019] The emulsifier is selected from one or more of calcium dodecylbenzenesulfonate, alkyl phenol formalin resin polyoxyethylene, phenylethyl phenol polyoxyethylene polyoxypropylene ether, fatty alcohol ethylene oxide-propylene oxide copolymer, styrene-based phenol polyoxyethylene ether, castor oil polyoxyethylene ether, and alkyl phenol ether phosphate; and / or

[0020] The thickening agent is selected from one or more of xanthan gum, organic bentonite, gum arabic, sodium alginate, magnesium aluminum silicate, carboxymethyl cellulose, and white carbon; and / or

[0021] The disintegrant is selected from one or more of sodium sulfate, ammonium sulfate, aluminum chloride, sodium chloride, ammonium chloride, bentonite, glucose, sucrose, starch, cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid, and tartaric acid; and / or

[0022] The antifreezing agent is selected from one or more of alcohols, alcohol ethers, chlorinated hydrocarbons, and inorganic salts; and / or

[0023] The antifoaming agent is selected from one or more of C 10 -C 20 saturated fatty acid compound, silicone oil, silicone compound, C8-C 10 fatty alcohol; and / or

[0024] The solvent is selected from one or more of benzene, toluene, xylene, mesitylene, methanol, ethanol, isopropanol, n-butanol, dimethyl sulfoxide, dimethylformamide, cyclohexanone, alkylene carbonate, diesel oil, solvent oil, vegetable oil, vegetable oil derivative, and water; and / or

[0025] The preservative is selected from one or more of propionic acid, sodium propionate, sorbic acid, sodium sorbate, potassium sorbate, benzoic acid, sodium benzoate, sodium p-hydroxybenzoate, methyl p-hydroxybenzoate, carboxin, and 1,2-benzisothiazolin-3-one; and / or

[0026] The stabilizer is selected from one or more of disodium hydrogen phosphate, oxalic acid, succinic acid, adipic acid, borax, 2,6-di-tert-butyl-p-cresol, triethanolamine oleate, epoxidized vegetable oil, kaolin, bentonite, attapulgite, white carbon, talc, montmorillonite, and starch; and / or

[0027] The synergist is selected from synergistic phosphorus, synergistic ether; and / or

[0028] The carrier is selected from one or more of the group consisting of ammonium salt, ground natural mineral, ground artificial mineral, silicate, resin, wax, solid fertilizer, water, organic solvent, mineral oil, vegetable oil and vegetable oil derivative;

[0029] Further, the pesticide composition can be prepared into any agriculturally acceptable dosage form, which is a solid preparation or a liquid preparation.

[0030] Further, the solid preparation includes powder, granule, pellet, tablet, bar, wettable powder, oil dispersible powder, emulsifiable powder, water dispersible granule, emulsion granule, water dispersible tablet, soluble powder, soluble tablet or soluble granule.

[0031] The liquid preparation includes soluble liquid, soluble gel, oil, spreadable oil, emulsion, emulsion concentrate, dispersible liquid, paste, water emulsion, oil emulsion, microemulsion, lipid suspension, microcapsule suspension, oil suspension, dispersible oil suspension, suspoemulsion, microcapsule suspension-suspension, microcapsule suspension-water emulsion or microcapsule suspension-suspoemulsion.

[0032] Further, the dosage form is a liquid preparation which is a suspension, and the solid preparation is a wettable powder or a water dispersible granule.

[0033] The present application also discloses the use of the pesticide composition as described above in the prevention and treatment of plant pests.

[0034] Further, the plant pest is a Hemiptera pest.

[0035] Further, the Hemiptera pest is a rice planthopper.

[0036] The present application has the following advantages:

[0037] 1. The pesticide composition of the present application is a reasonable mixture of different single compounds, which can significantly improve the prevention and treatment effect of the single compound.

[0038] 2. The pesticide composition of the present application can effectively reduce the use amount of pesticides, thereby reducing the production cost and the pollution to the environment.

[0039] 3. The pesticide composition of the present application has a significant effect on the prevention and treatment of rice planthoppers, and can reduce the development of target pest resistance and prolong the use time of the single compound. DETAILED DESCRIPTION

[0040] In order to make the technical scheme, purpose and advantages of the present application clearer and more apparent, the present application is described in conjunction with the following specific embodiments, but the present application can be realized in various forms and should not be limited by the embodiments described herein.

[0041] Preparation of the formulation example:

[0042] Preparation example 1: 18% isoflualanam·triflubicid suspension (1:8)

[0043] Formulation composition: 2% isoflualanam, 16% triflubicid, 2% alkyl aryl polyoxyethylene polyoxypropylene ether, 2% tristyrylphenol ethoxylate phosphate ester, 1% sodium dodecyl sulfate, 0.25% xanthan gum, 5% glycerol, 0.1% sodium sorbate, 0.5% silicone oil, deionized water to make up the balance;

[0044] Preparation method: according to the formulation ratio, the active ingredients, surfactants and other functional additives are sequentially placed in the reaction kettle, mixed uniformly with water, sheared at high speed, wet sand ground, and finally filtered to obtain the suspension product.

[0045] Preparation example 2: 24% isoflualanam·triflubicid wettable powder (7:1)

[0046] Formulation composition: 21% isoflualanam, 3% triflubicid, 2% naphthalene sulfonate formaldehyde condensate, 5% alkyl polyoxyethylene ether sodium sulfonate, 3% Laka powder BX, 5% white carbon black, kaolin to make up the balance;

[0047] Preparation method: according to the formulation ratio, the effective ingredients and dispersants, wetting agents and fillers are mixed and uniformly stirred in the stirring kettle, and then uniformly mixed by air jet mill for multiple times to prepare the wettable powder of the present invention composition.

[0048] Preparation example 3: 33% isoflualanam·triflubicid water dispersible granules (10:1)

[0049] Formulation composition: 30% isoflualanam, 3% triflubicid, 5% sodium lignosulfonate, 2% succinate sulfonate, 8% polycarboxylic acid sodium salt, 3% sodium dodecyl sulfate, 10% ammonium sulfate, starch to make up the balance;

[0050] Preparation method: according to the formulation ratio, the active ingredients are added to the carrier, and the surfactants and other functional additives are added therein, mixed, and then 10-25% water is added after air jet crushing, followed by kneading, granulation, drying and screening to prepare the water dispersible granule product; or the crushed powder is sprayed with water in a fluidized bed granulator, granulated, dried, and then screened to prepare the product.

[0051] Preparation example 4: 15% isoflualanam·dicloromezotiaz suspension (3:2)

[0052] Formulation composition: 9% isoflualanam, 6% dicloromezotiaz, 1% isomeric tridecanol polyoxyethylene ether, 2% castor oil polyoxyethylene ether, 2% polyoxyethylene sorbitan monooleate, 2% triphenyl ethenyl phenol ethoxylate phosphate, 1% sodium polycarboxylate, 1% magnesium aluminum silicate, 0.25% xanthan gum, 1% sodium benzoate, 5% ethylene glycol, 0.5% silicone oil, deionized water to make up the balance;

[0053] Preparation method: same as Preparation Example 1.

[0054] Preparation Example 5: 38.5% isoflualanam·dicloromezotiaz wettable powder (1:10)

[0055] Formulation composition: 3.5% isoflualanam, 35% dicloromezotiaz, 6% sodium lignosulfonate, 3% sodium alkyl polyoxyethylene ether sulfonate, 2% fatty alcohol polyoxyethylene ether sulfate, 5% white carbon black, 20% starch, kaolin to make up the balance;

[0056] Preparation method: same as Preparation Example 2.

[0057] Preparation Example 6: 21% isoflualanam·dicloromezotiaz water dispersible granules (6:1)

[0058] Formulation composition: 18% isoflualanam, 3% dicloromezotiaz, 8% succinate sulfonate, 3% Lai Kao powder BX, 2% sodium dodecyl benzene sulfonate, 6% sodium lignosulfonate, 5% white sugar, kaolin to make up the balance;

[0059] Preparation method: same as Preparation Example 3.

[0060] Preparation Example 7: 22.5% isoflualanam·fenmezoditiaz suspension concentrate (8:1)

[0061] Formulation composition: 20% isoflualanam, 2.5% fenmezoditiaz, 1% triphenyl ethenyl phenol polyoxyethylene ether, 1% alkyl fatty alcohol polyoxyethylene ether sulfate, 5% styrene phenol polyoxyethylene ether phosphate, 2% isomeric tridecanol polyoxyethylene ether, 0.25% xanthan gum, 1% magnesium aluminum silicate, 5% glycerol, 0.1% sodium benzoate, 0.5% silicone oil, deionized water to make up the balance;

[0062] Preparation method: same as Preparation Example 1.

[0063] Preparation Example 8: 38% isoflualanam·fenmezoditiaz wettable powder (1:18)

[0064] Formulation composition: 2% isoflualanam, 36% fenmezoditiaz, 6% lignosulfonate, 4% naphthalene sulfonate formaldehyde condensate, 3% sodium dodecyl sulfate, 20% starch, kaolin to make up the balance;

[0065] Preparation method: same as Preparation Example 2.

[0066] Preparation Example 9: 30% isoflualanam·fenmezoditiaz water dispersible granules (2:1)

[0067] Formulation composition: 20% isoflualanam, 10% fenmezoditiaz, 3% fatty alcohol polyoxyethylene ether, 10% naphthalene sulfonate formaldehyde condensate, 3% styrene phenol polyoxyethylene ether sulfate, 2% sodium lignosulfonate, 10% ammonium sulfate, starch to make up the balance;

[0068] Preparation method: same as Preparation Example 3.

[0069] Example 1: indoor bioactivity determination test of rice brown planthopper

[0070] Test target: Nilaparvata lugens, 3rd instar nymphs.

[0071] Test agent: trifluminas, dicloromezotiaz, fenmezoditiaz, isoflualanam.

[0072] Test method: Take rice seedlings growing healthily, uniformly, and about 10 cm long, 15 seedlings for 1 group, wash and dry in a cool place for standby. Dissolve the test agent in a suitable solvent to prepare a mother liquor of a certain concentration, then dilute the mother liquor with 0.1% Tween-80 aqueous solution to 5 series. After immersing the rice seedlings in the solution for 30 s, take them out and dry, wrap the roots with absorbent cotton, immerse the bottom in a disposable plastic cup, insert about 30 standard and consistent 3rd instar nymphs into each cup, and seal with gauze, repeat 4 times for each treatment, and use 0.1% Tween-80 aqueous solution as a blank control. After the insects are inserted, place them in an intelligent artificial climate chamber with a temperature of (28±1)℃, a relative humidity of 75%±5%, and a light cycle of 16L:8D. Check the mortality after 48 h, and gently touch the insect body with a No. 0 hair brush, and those that do not move at all are considered dead.

[0073] Calculation method:

[0074] According to the survey data, the mortality of each treatment is calculated. The calculation is as follows:

[0075]

[0076] wherein:

[0077] P - mortality, in percent (%);

[0078] K - represents the number of dead insects, in head;

[0079] N - represents the total number of insects, in head.

[0080]

[0081] wherein:

[0082] P1 - corrected mortality, in percent (%);

[0083] P t - treatment mortality, in percent (%);

[0084] P0 - blank control mortality, in percent (%).

[0085] If the control mortality is < 5%, no correction is needed; if the control mortality is between 5% and 20%, the mortality should be corrected according to the corrected mortality formula; if the control mortality is > 20%, the test should be repeated.

[0086] The statistical analysis system is used to analyze the toxicity regression equation, the correlation coefficient and the LC 50 values, and to evaluate the activity of the test agent on the biological test material.

[0087] The co-toxicity coefficient (CTC value) of the mixture is calculated according to the following formula:

[0088]

[0089] wherein:

[0090] ATI - the measured toxicity index of the mixture;

[0091] S - the LC 50 of the standard insecticide, in milligrams per liter (mg / L);

[0092] M - the LC 50 of the mixture, in milligrams per liter (mg / L).

[0093] TTI = TI A x P A + TI B x P B

[0094] wherein:

[0095] TTI - the theoretical toxicity index of the mixture;

[0096] TI A Toxicity index of A agent;

[0097] P A Percentage of A agent in the mixture, in percentage (%);

[0098] TI B Toxicity index of B agent;

[0099] P B Percentage of B agent in the mixture, in percentage (%).

[0100]

[0101] In the formula:

[0102] CTC - Co-toxicity coefficient;

[0103] ATI - Actual toxicity index of the mixture;

[0104] TTI - Theoretical toxicity index of the mixture.

[0105] The co-toxicity coefficient CTC of the combination is greater than or equal to 120, which shows synergistic effect; CTC is less than or equal to 80, which shows antagonistic effect; 80 < CTC < 120, which shows additive effect. The results of the indoor test are shown in the following table:

[0106] Table 1 Results of indoor bioactivity test of isoflualanam combined with trifluminuron on rice brown planthopper

[0107]

[0108]

[0109] The results of the indoor test show that the combination of isoflualanam and trifluminuron has obvious synergistic effect on rice brown planthopper at a suitable mass ratio. When the mass ratio of isoflualanam to trifluminuron is 1:30-40:1, the co-toxicity coefficient of the combination on brown planthopper is greater than 120, showing synergistic effect; when the mass ratio of isoflualanam to trifluminuron is 1:16-35:1, the co-toxicity coefficient is greater than 130, showing obvious synergistic effect; when the mass ratio of isoflualanam to trifluminuron is 1:8-25:1, the co-toxicity coefficient is greater than 140, showing significant synergistic effect.

[0110] Table 2 Results of indoor bioactivity test of isoflualanam combined with fenmezoditiaz on rice brown planthopper

[0111]

[0112] The indoor bioactivity test results show that isoflualanam and fenmezoditiaz have obvious synergistic effect on Nilaparvata lugens at a suitable mass ratio. The synergistic coefficient of isoflualanam and fenmezoditiaz at a mass ratio of 1:40-25:1 is greater than 120, showing obvious synergistic effect; the synergistic coefficient of isoflualanam and fenmezoditiaz at a mass ratio of 1:30-18:1 is greater than 130, showing obvious synergistic effect; the synergistic coefficient of isoflualanam and fenmezoditiaz at a mass ratio of 1:18-18:1 is greater than 140, showing significant synergistic effect.

[0113] Table 3 Indoor bioactivity test results of isoflualanam and dicloromezotiaz on Nilaparvata lugens

[0114]

[0115]

[0116] The indoor test results show that isoflualanam and dicloromezotiaz have obvious synergistic effect on Nilaparvata lugens at a suitable mass ratio. The synergistic coefficient of isoflualanam and dicloromezotiaz at a mass ratio of 1:30-20:1 is greater than 120, showing obvious synergistic effect; the synergistic coefficient of isoflualanam and dicloromezotiaz at a mass ratio of 1:30-15:1 is greater than 130, showing obvious synergistic effect; the synergistic coefficient of isoflualanam and dicloromezotiaz at a mass ratio of 1:20-15:1 is greater than 140, showing significant synergistic effect.

[0117] Example 2: Field test of isoflualanam and dicloromezotiaz for controlling Nilaparvata lugens

[0118] Test site: The test site is located in Xifeng Village, Simaqiao Town, Dao County, Yongzhou City, Hunan Province, and the soil fertility of the test site is medium to high, and irrigation is convenient.

[0119] Test crop: rice (Taiyou 2068).

[0120] Test target: Nilaparvata lugens.

[0121] Test design: The test has 4 repetitions, a total of 32 plots, and the plot area is 63m 2 left and right (7m x 9m), arranged in random blocks. Mud dikes are built between plots, and a protection row of more than 1m is set around.

[0122] The 3WBD-16 type backpack electric sprayer was used for uniform spraying, and the spraying liquid amount was 657 kg / hm 2 A 3-5 cm water layer was reserved in the field during spraying, and the water was maintained for 1 week after spraying.

[0123] Test investigation: a total of 4 times of field investigation were conducted, and the insect population base was investigated before spraying on September 12, 2023, and the number of live insects was investigated 7d, 14d and 21d after spraying.

[0124] Investigation method: 10 points were investigated by parallel jumping method in each plot, 2 clusters per point, the investigation time was fixed at 8:00-10:00 AM, the fixed investigation personnel were used for each investigation (to reduce the investigation error), and when investigating, the enamel tray was placed under the rice, and 3 times of forceful beating towards the enamel tray direction was performed, so that the rice planthopper fell into the enamel tray, and the number of live insects was counted.

[0125] Drug damage investigation was conducted every day, and whether the rice plants had drug damage symptoms such as leaf wilting, plant dwarfing and leaf deformation caused by spraying was recorded.

[0126] Drug efficacy calculation method:

[0127]

[0128]

[0129] The field efficacy prevention and treatment results are as follows:

[0130] Table 4: Field prevention and treatment of rice planthopper

[0131]

[0132]

[0133] After spraying, it was found that the growth of rice was good after spraying each complex preparation, the dose of sprayed drug was within the safe range, which did not affect the growth of plants, and the prevention and treatment effect on rice planthopper was ideal, which ensured the healthy growth of rice.

[0134] In summary, through indoor toxicity determination and field efficacy test, it can be seen that the pesticide composition of the present application has good prevention and treatment effect on rice planthopper, is safe to target crops, has significant prevention and treatment effect, and is superior to single agent in delaying the generation of drug resistance and prolonging the efficacy.

[0135] While specific embodiments of the application have been described in detail, the disclosure of the application is not limited to the particular form described. Rather, the disclosure of the application is to cover all modifications, equivalents, and alternatives falling within the scope of the application as defined by the following claims and the legal equivalents thereto.

Claims

1. An application of a pesticide composition containing a methanogenic compound for the control of hemiptera pests, characterized in that, The pesticide composition comprises active ingredient A and active ingredient B. Active ingredient A is isoflualanam, and active ingredient B is a metronid compound, specifically trifluorophenylpyrimidine. The mass ratio of active ingredient A to active ingredient B is 1:30 to 40:

1. The hemiptera pest is the rice planthopper.

2. The application according to claim 1, characterized in that, The active ingredient B is trifluorophenylpyrimidine, and the mass ratio of active ingredient A to active ingredient B is 1:16 to 35:

1.

3. The application according to claim 2, characterized in that, The active ingredient B is trifluorophenylpyrimidine, and the mass ratio of active ingredient A to active ingredient B is 1:8 to 25:

1.

4. The application according to claim 1, characterized in that, Based on the total weight of the pesticide composition (100 wt%), the sum of the contents of active ingredient A and active ingredient B in the pesticide composition is 0.5 to 80 wt%.

5. The application according to claim 1, characterized in that, In addition to the active ingredient, the pesticide composition also includes an adjuvant, which is selected from one or more of the following: wetting agent, dispersant, emulsifier, thickener, disintegrant, antifreeze, defoamer, solvent, preservative, stabilizer, synergist or carrier.

6. The application according to claim 1, characterized in that, The pesticide composition can be prepared into any agriculturally acceptable formulation, which is a solid formulation or a liquid formulation; the liquid formulation is a suspension, and the solid formulation is a wettable powder or a water-dispersible granule.

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