Herbicidal composition containing pyroxasulfone, thifensulfuron-methyl and saflufenacil, and use thereof

Abstract

An herbicidal composition, and a use thereof. The herbicidal composition comprises pyroxasulfone, thifensulfuron-methyl, and saflufenacil, the weight ratio of pyroxasulfone:thifensulfuron-methyl to saflufenacil being 10:1:0.5-2. The herbicide composition combines, for the first time, the high-activity herbicide pyroxasulfone with thifensulfuron-methyl and saflufenacil, which have a synergistic herbicidal effect, greatly reducing the amount of agricultural chemicals used, reducing the cost of chemicals, and reducing the adverse effects of agricultural chemicals on the environment.

Description

A herbicide composition containing pyroxasulfone, thifensulfuron-methyl and saflufenacil and application thereof TECHNICAL FIELD

[0001] The present application belongs to the technical field of pesticide compositions, and particularly relates to a herbicide composition containing pyroxasulfone, thifensulfuron-methyl and saflufenacil and application thereof. BACKGROUND

[0002] With the continuous use of herbicides for many years, the tolerance of weeds is increasing, especially the resistance to post-emergence herbicides is increasing; farmers increase the use dosage to obtain better control effect, which on the one hand increases the planting cost, and on the other hand increases the potential environmental risk. Developing high-efficiency, low-residue and broad-spectrum herbicide formula is an effective solution to weed resistance in farmland, and is also a feasible measure to achieve the goal of pesticide and fertilizer reduction and efficiency increase.

[0003] Pyroxasulfone: the English general name is pyroxasulfone, the chemical name is 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-isoxazole, which is suitable for pre-emergence control of Lolium multiflorum, Beckmannia, Alopecurus, Digitaria sanguinalis, Eragrostis etc. and some broadleaf weeds in wheat, corn, soybean, peanut, etc. The active ingredient dosage is 75-150 g / ha, which is about 1 / 10 of acetochlor. According to the World Pesticide Manual Herbicide Volume Second Edition, the soil half-life DT50 of pyroxasulfone can reach more than 142 days, and the effective period is long. The International Herbicide Resistance Action Committee (HRAC) classifies it into K3 herbicides.

[0004] Thifensulfuron-methyl: the English general name is thifensulfuron-methyl, the chemical name is 3-(4-methoxy-6-methyl-1,3,5-triazinyl-2-ylaminocarbonylaminosulfonyl)thiophene-2-carboxylic acid methyl ester, which is mainly used for pre-emergence control of a variety of annual and perennial broadleaf weeds in cereals, soybeans and corns, etc. The active ingredient dosage is 15-30 g / ha, which is about 1 / 50 of atrazine. According to the data of The Pesticide Manual, the soil half-life DT50 of thifensulfuron-methyl can reach 7 days, and the DT90 can reach 50 days. The International Herbicide Resistance Action Committee (HRAC) classifies it into B herbicides.

[0005] Saflufenacil, the common name of which is N'-{2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)pyrimidin-1(2H)-yl]-4-fluorobenzoyl}-N-isopropyl-N-methylsulfamide, is mainly used for controlling more than 100 kinds of annual broadleaf weeds such as Solanum nigrum, Poterium chinense, Galium aparine, Euphorbia humifusa, Abutilon theophrasti, etc. in soybean, wheat, corn, orchard, pre-emergence and post-emergence. The active ingredient dosage is 15-60 g / ha, which is about 1 / 50-1 / 25 of that of atrazine. According to the data in The Pesticide Manual, the soil half-life DT50 of saflufenacil is about 15 days.

[0006] At present, there is no report on the combination of pyroxasulfone, thifenuron and saflufenacil, and there is no report on the combination solving the problem of low removal efficiency of high-resistant gramineae and malignant broadleaf and sedge weeds in farmland. SUMMARY

[0007] This section is intended to summarize some aspects of the embodiments of the present application and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the abstract of the specification and the title of the application in order to avoid obscuring the purpose of this section, the abstract of the specification and the title of the application, and such simplifications or omissions cannot be used to limit the scope of the present application.

[0008] In view of the above and / or problems existing in the prior art, the present application is proposed.

[0009] Therefore, the purpose of the present application is to overcome the deficiencies in the prior art, and to provide a herbicide composition containing pyroxasulfone, thifenuron and saflufenacil.

[0010] To solve the above technical problems, the present application provides the following technical scheme: a herbicide composition containing pyroxasulfone, thifenuron and saflufenacil, comprising pyroxasulfone, thifenuron and saflufenacil, wherein the weight ratio of pyroxasulfone:thifenuron:saflufenacil is 10:1:0.5-2.

[0011] As a preferred scheme of the composition of the present application, the weight ratio of pyroxasulfone:thifenuron:saflufenacil is 10:1:1.

[0012] As a preferred scheme of the composition of the present application, the herbicide composition further comprises a pesticide-acceptable surfactant and an auxiliary carrier.

[0013] As a preferred scheme of the composition of the present application, wherein: the pesticide-acceptable surfactant comprises castor oil polyoxyethylene ether, calcium dodecyl benzene sulfonate, dichlorpropylamine, polymeric carboxylate, sodium dodecyl sulfate.

[0014] As a preferred scheme of the composition of the present application, wherein: the auxiliary carrier comprises white carbon black, organic bentonite, ethyl acetate, solvent oil S-150#, methyl oleate, ammonium sulfate, diatomite.

[0015] As a preferred scheme of the composition of the present application, wherein: in the composition, the mass percentage of the fenclorim, thiencarbazone-methyl and metazachlor is 11.5% to 78% of the total mass of the composition, and the rest is the pesticide-acceptable surfactant and the auxiliary carrier.

[0016] As a preferred scheme of the composition of the present application, wherein: the herbicide composition dosage form comprises a suspension concentrate, a dispersible oil suspension concentrate, a wettable powder, a water dispersible granule, and a dry suspension concentrate.

[0017] Another object of the present application is to overcome the deficiencies in the prior art and provide the use of the herbicide composition, which is used for closed weed control in wheat, corn, soybean, peanut crops and corn-soybean, corn-peanut complex planting cultivation modes.

[0018] The present application has the following beneficial effects:

[0019] (1) The herbicide composition provided by the present application first combines the high-activity herbicide fenclorim with thiencarbazone-methyl and metazachlor, has a synergistic weed-killing effect, greatly reduces the use dose of pesticides, reduces the cost of pesticide use, and reduces the adverse effects of pesticides on the environment.

[0020] (2) The herbicide composition provided by the present application has different mechanisms of action and complementary weed-killing spectrums, and has an ideal effect on difficult-to-control weeds such as Italian ryegrass and black nightshade.

[0021] (3) The herbicide composition provided by the present application has high safety for wheat, corn, soybean, and peanut, and can solve the problem of lack of drug selection in corn-soybean and corn-peanut complex planting. DETAILED DESCRIPTION

[0022] In order to make the above-mentioned objects, features and advantages of the present application more obvious and easy to understand, the specific embodiments of the present application will be described in detail below with reference to the description examples.

[0023] In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. However, it will be apparent to one skilled in the art that the present application can be practiced without the specific details set forth in this description. In other instances, well-known methods have not been described in detail in order to avoid unnecessarily obscuring the present application. Therefore, the present application is not intended to be limited by the specific embodiments disclosed herein, which can be practiced with variations other than those described herein.

[0024] Second, the "one embodiment" or "an embodiment" referred to herein means a specific feature, structure, or characteristic under consideration can be included in at least one implementation of the present application. The "in one embodiment" appearing in different places in the specification does not mean the same embodiment, nor does it mean an embodiment that is separate from or mutually exclusive with other embodiments.

[0025] The herbicide composition of the present application comprises the following components: metrafenone, thifensulfuron-methyl and bensulfuron-methyl. The herbicide composition can contain a herbicide safener acceptable in the art, such as, for example, dichloromethyl, isoxadifen-ethyl, cyprosulfamide, fenclorim, ademetionine, furilazole, and dichlorprop.

[0026] The herbicide composition of the present application can be processed into a dispersible suspension concentrate, a suspension concentrate, a wettable powder, a water dispersible granule, and other suitable formulations for agricultural use by adding appropriate agricultural adjuvants and using methods known to those skilled in the art.

[0027] The production processes of the various formulations of the herbicide composition provided by the present application are all known in the art and will not be described here.

[0028] The herbicide composition provided by the present application is usually used by mixing with water and spraying. Other application techniques can also be used as needed. The herbicide composition provided by the present application is used before the weeds germinate after the crops are sown.

[0029] Embodiment 1

[0030] (1) 30% metrafenone · thifensulfuron-methyl · bensulfuron-methyl dispersible oil suspension concentrate:

[0031] (2) Preparation method of the dispersible oil suspension concentrate

[0032] Mix metrafenone, thifensulfuron-methyl, bensulfuron-methyl, surfactants, and adjuvants in a preparation kettle, shear for 20-30 min until uniform, and then put into a sand mill for coarse grinding. Cooling salt water is used during the grinding process, and the temperature is controlled within 30°C.

[0033] Coarsely ground mixture is finely ground, and the particle size after grinding is controlled to be less than 15 μm.

[0034] Embodiment 2

[0035] (1) 72% of the mixture of meththiuron, pyroxasulfone and foramsulfuron water dispersible granule:

[0036] (2) Preparation method of water dispersible granule

[0037] The meththiuron, pyroxasulfone, foramsulfuron, surfactant and auxiliary materials are added into a double-cone mixer and mixed uniformly, then crushed by an airflow crusher to a particle size of 7-18 μm, and then added into the double-cone mixer for kneading with water to prepare the water dispersible granule.

[0038] Example 3

[0039] Colby method for determining the combined action of the composition: the herbicidal effect of the three components is evaluated by determining the survival rate and combined action of the composition on gramineous and broadleaf weeds.

[0040] The specific implementation is as follows:

[0041] The example refers to NY / T 1155.3-2006 "Guidelines for the Laboratory Bioassay of Pesticides Herbicides Part 3: Active Ingredient Test Soil Drench Method", NY / T 1155.7-2006 "Guidelines for the Laboratory Bioassay of Pesticides Herbicides Part 7: Combined Action Test of Mixtures". The combined action of meththiuron, pyroxasulfone and foramsulfuron on common gramineous weeds and broadleaf weeds in farmland is illustrated by indoor toxicity determination.

[0042] Preparation of the test agent: 97% meththiuron technical material, 98% pyroxasulfone technical material and 97% foramsulfuron technical material are respectively dissolved in an appropriate amount of acetone, and then prepared into a desired concentration with 0.1% surfactant (tween 80:span 20=2:1) aqueous solution for standby use.

[0043] Test method: The test adopts a greenhouse potting method. The seeds of Solanum nigrum L., Eclipta prostrata (L.) L., Lolium multiflorum Lamk. and Digitaria sanguinalis (L.) Scop. are respectively sowed in a small flower pot filled with 3 / 5 culture soil after germination, 8x8 seeds are sowed in each pot, and 1-2 mm of soil is covered after sowing.

[0044] Water is added to the tray containing the small flower pots, and after the water completely soaks the culture soil, the excess water in the tray is poured out.

[0045] Soil spraying treatment is performed on the 24th hour after sowing with an ASS-5 walking type spray tower, and water is set as a blank control, and then the pots are transferred to the greenhouse for further cultivation and observation. The fresh weight of the aboveground part of weeds in each treatment is investigated after 20 days.

[0046] Except for 1-2 days after spraying, regular watering is needed to keep the soil humidity.

[0047] Weed survival rate calculation method:

[0048] The herbicidal activity of the mixture was tested by Colby method, i.e. E0=ABC / 10000; in the formula, A is the single-agent weed survival rate of the herbicide (metominostrobin), B is the single-agent weed survival rate of the herbicide (thiencarbazone-methyl), C is the single-agent weed survival rate of the herbicide (saflufenacil), E0 is the theoretical survival rate of the mixed herbicide, and E is the measured survival rate of the mixed herbicide.

[0049] According to Colby method, when E0-E≥10%, it indicates that the mixed herbicide has a synergistic effect; when E0-E≤-10%, it indicates that the mixed herbicide has an antagonistic effect; and when the value of E0-E is between ±10%, it indicates that the mixed herbicide has an additive effect.

[0050] The indoor survival rates of the test target weeds and the combined products of the metominostrobin, thiencarbazone-methyl and saflufenacil composition are shown in the following tables.

[0051] Table 1 Test results of the survival rate of Solatium nigrum treated by each agent and evaluation results of the combined effect

[0052] Table 2 Test results of the survival rate of Avena fatua treated by each agent and evaluation results of the combined effect

[0053] Table 3 Test results of the survival rate of Lolium multiflorum treated by each agent and evaluation results of the combined effect

[0054] Table 4 Test results of the survival rate of Digitaria sanguinalis treated by each agent and evaluation results of the combined effect

[0055] Analysis of the results of application test 1:

[0056] The results in Table 1 show that the combinations of pyroxydiostrobin + thienopyr + metazachlor exhibit synergistic effect on the tested weed Solanum nigrum at the doses of 60+6+6, 60+6+9, 60+6+12, 90+9+6, 90+9+9, 90+9+12, 120+12+6, 120+12+9, 120+12+12; the other dose groups exhibit additive effect; correspondingly, pyroxydiostrobin:thienopyr:metazachlor = 10:1:0.5, 10:1:0.67, 10:1:0.75, 10:1:1, 10:1:1.33, 10:1:1.5, 10:1:2; it is presumed that when pyroxydiostrobin:thienopyr:metazachlor = 10:1:0.5-2, the combinations exhibit obvious synergistic effect on the broadleaf weed Solanum nigrum, and the other ratios exhibit additive effect.

[0057] The results in Table 2 show that the combinations of pyroxydiostrobin + thienopyr + metazachlor exhibit synergistic effect on the tested weed Solanum nigrum at the doses of 60+6+6, 60+6+9, 60+6+12, 90+9+6, 90+9+9, 90+9+12, 120+12+6, 120+12+9, 120+12+12; the other dose groups exhibit additive effect; correspondingly, pyroxydiostrobin:thienopyr:metazachlor = 10:1:0.5, 10:1:0.67, 10:1:0.75, 10:1:1, 10:1:1.33, 10:1:1.5, 10:1:2; it is presumed that when pyroxydiostrobin:thienopyr:metazachlor = 10:1:0.5-2, the combinations exhibit obvious synergistic effect on the broadleaf weed Solanum nigrum, and the other ratios exhibit additive effect.

[0058] The results in Tables 3 and 4 show that the combinations of pyroxydiostrobin + thienopyr + metazachlor exhibit additive effect on the tested Lolium multiflorum and Digitaria sanguinalis at the tested ratios; this result is related to the herbicidal spectrum of metazachlor and thienopyr, which mainly prevent broadleaf or sedge weeds, and only partially inhibit the gramineous weeds such as Lolium multiflorum and Digitaria sanguinalis;

[0059] When pyroxydiostrobin:thienopyr:metazachlor = 10:1:0.5-2, the combinations exhibit synergistic effect on the broadleaf weeds; preferably, when pyroxydiostrobin:thienopyr:metazachlor = 10:1:1, the E0-E value is the largest, and the synergistic effect on the broadleaf weeds Solanum nigrum and Solanum capsicoides is more obvious; the combinations do not have antagonistic effect on the tested gramineous weeds Lolium multiflorum and Digitaria sanguinalis.

[0060] Example 4

[0061] The selective index of the combinations in Example 1 was determined (with Echinochloa crus-galli and Chenopodium murale as the tested weeds, and Triticum aestivum, Zea mays, Glycine max and Arachis hypogaea as the tested crops), and the specific determination method is as follows:

[0062] The experiment adopts greenhouse potting method, and the seeds of wheat, corn, soybean and peanut are sowed in small flower pots filled with 3 / 5 culture soil, 3*3 seeds per pot. The seeds of barnyard grass and goosegrass are sowed in small flower pots filled with 3 / 5 culture soil after germination, 8*8 seeds per pot, and then covered with 1-2mm soil. Add water in the tray with small flower pots, and then pour out the excess water after the culture soil is completely soaked.

[0063] Soil spraying treatment is carried out with ASS-5 walking spray tower 24h after sowing, and water is used as blank control. Then, the pots are transferred to the greenhouse for further cultivation and observation. After 30 days, the plant height of wheat, corn, soybean and peanut, and the fresh weight of weeds in each treatment are investigated.

[0064] Except for watering 1-2 days after spraying, regular watering is carried out to maintain soil humidity.

[0065] Weed control effect calculation method:

[0066] The minimum effective dose ED of the pesticide to the main sensitive weeds is used as the evaluation index of herbicide activity, and the highest safe dose ED of the pesticide to the crop with less than 10% of plant height inhibition rate is used as the evaluation index of crop safety. 90 10 (NOEL) is used as the evaluation index of crop safety.

[0067] The selectivity coefficient I = ED 10 / ED 90 ;

[0068] When I≥4, it is considered that the pesticide has excellent selectivity and good field promotion value.

[0069] When I≥2, it is considered that the pesticide has certain selectivity and can be tested in the field.

[0070] When I<2, it is considered that the pesticide has poor selectivity and no development potential.

[0071] The test crops are wheat, corn, soybean and peanut, and the target weeds are barnyard grass and goosegrass. The selectivity index is determined as shown in the following table:

[0072] Table 5 Selectivity index determination results of 530% mefenoxam · thiencarbazone-methyl · metazachlor OD on test crops and barnyard grass

[0073] Table 6 Selectivity index determination results of 630% mefenoxam · thiencarbazone-methyl · metazachlor OD on test crops and goosegrass

[0074] Analysis:

[0075] ​The results in Table 5 show that the selectivity index I of 30% metrafenone · thifenpyr · metazachlor OD between the tested crops wheat, corn, soybean, peanut and the weed Echinochloa crusgalli is 13.22, 13.83, 9.92, 5.36 respectively, indicating that the composition of Example 1 has excellent selectivity between the tested crops and the weed Echinochloa crusgalli;

[0076] The results in Table 6 show that the selectivity index I of 30% metrafenone · thifenpyr · metazachlor OD between the tested crops wheat, corn, soybean, peanut and the weed Chenopodium album is 13.56, 14.18, 10.17, 5.50 respectively, indicating that the composition of Example 1 has excellent selectivity between the tested crops and the weed Chenopodium album;

[0077] The composition has high safety to wheat, corn, soybean, peanut and excellent effect on weed control, and the effect lasts for more than 30 days, which can be used for controlling common grasses and broadleaf weeds in the above crops, and can be used for corn-soybean and corn-peanut compound planting to solve the problem of lack of drugs in compound planting mode.

[0078] Comparative Example 1

[0079] This comparative example is used to explore the effect of herbicide combination on the survival rate of weeds (herbicidal effect) and the safety of crops, specifically:

[0080] The active ingredients of the adjusted herbicides are respectively:

[0081] a1: metrafenone + thifenpyr + metazachlor = 25% + 5% + 0%;

[0082] b1: metrafenone + thifenpyr + metazachlor = 25% + 0% + 5%;

[0083] c1: metrafenone + thifenpyr + metazachlor = 30% + 0% + 0%; other ratios are the same as Example 1.

[0084] Comparison of indoor safety and control effect with Example 1 (metrafenone: thifenpyr: metazachlor = 25 + 2.5 + 2.5) composition;

[0085] Each group of raw materials is dissolved by acetone, and then 0.1% surfactant (Tween 80: Span 20 = 2:1) aqueous solution is used to prepare the test solution, and the dose concentration is 180 ga.i / ha. The dose concentration of Example 1 is 180 ga.i / ha, and the results are shown in Table 7.

[0086] Table 7

[0087] In the comparative examples a1, b1, c1 at the dose concentration of 180 ga.i. / ha, the plant height inhibition rates on peanut, soybean, corn and wheat decrease in turn, and the plant height inhibition rates are higher than those of Example 1, especially the plant height inhibition rates of a1 group on soybean and peanut are >10%, the herbicide inhibition exceeds the acceptable safety range. It is shown that the composition ratio not only affects the herbicidal effect, but also greatly affects the safety of crops. In combination with the herbicidal effect and safety data, the composition of the present application has ideal comprehensive herbicidal effect and safety.

[0088] It should be noted that the above examples are only used to illustrate the technical solutions of the present application but not limit the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or replaced equivalently without departing from the spirit and scope of the present application, and they should be covered in the scope of the present application.

Claims

1. A herbicidal composition comprising pyroxasulfone, thifensulfuron-methyl and saflufenacil, characterized in that: The herbicide composition comprises mesotrione, thifensulfuron-methyl and metazachlor, wherein the weight ratio of mesotrione:thifensulfuron-methyl:metazachlor is 10:1:0.5-2.

2. The composition of claim 1, wherein: The weight ratio of mesotrione:thifensulfuron-methyl:metazachlor is 10:1:

1.

3. The composition of claim 1 or 2, wherein: The herbicide composition further comprises a pesticide-acceptable surfactant and an auxiliary carrier.

4. The composition of claim 3, wherein: The pesticide-acceptable surfactant comprises castor oil polyoxyethylene ether, calcium dodecyl benzene sulfonate, dichloropropylamine, polymeric carboxylate, sodium dodecyl sulfate.

5. The composition of claim 3, wherein: The auxiliary carrier comprises white carbon black, organic bentonite, ethyl acetate, solvent oil S-150#, methyl oleate, ammonium sulfate, diatomite.

6. The composition of any one of claims 1, 2, 4, 5, wherein: In the composition, the mass percentage of mesotrione, thifensulfuron-methyl and metazachlor is 11.5%-78%, and the rest is the pesticide-acceptable surfactant and the auxiliary carrier.

7. The composition of claim 1, wherein: The herbicide composition dosage form comprises suspension concentrate, dispersible oil suspension concentrate, wettable powder, water dispersible granules.

8. Use of the herbicide composition according to any one of claims 1 to 7, characterized in that: The composition is used for closed weed control in wheat, corn, soybean, peanut crops and corn-soybean, corn-peanut complex planting cultivation modes.

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