An automatic triggering device and method for a nasal spray

Abstract

The present invention relates to an automatic triggering device for nasal sprays and a method of use, belonging to the technical field of biomedical scientific research. The device includes a distribution box, a control system, a triggering system, and a sample-carrying system. The triggering system uses the principle of a magnetic coil to drive physical pressing, featuring smooth control and rapid response. The control system can adjust the triggering force, speed, and number of times of the nasal spray, enabling real-time control of the nasal spray triggering device and real-time monitoring of data. The sample-carrying system fixes the nasal spray, adjusts the triggering angle, height, and triggering type of the nasal spray, is applicable to different types of nasal sprays, and is equipped with a high-precision planar tensile-compressive force weight sensor with a weighing range of 0-10 kg and a repeatability accuracy of 0.3%, which can provide real-time feedback on the triggering force and adjust control parameters. The present invention can achieve automatic / manual continuous triggering of nasal sprays, be used to test the spraying performance and uniformity of different models of nasal sprays under different conditions, and detect and analyze the physical characteristics of the sprayed droplets of nasal sprays under different triggering conditions.

Description

Technical Field

[0001] The present invention belongs to the technical field of biomedical technology, and particularly relates to an automatic triggering device for a nasal spray and a using method thereof. Background Art

[0002] In recent years, various nasal sprays with different models and doses have been developed around the world for the fields of biological and medical research. However, in research, it is often necessary to evaluate various spraying performances of nasal sprays to guide the further optimization of nozzle design and the development of new nasal spray products with excellent performances.

[0003] When evaluating the spraying effect of a nasal spray, the currently commonly used test method is to manually press the nasal spray. This test method has the following defects: First, the manual pressing force is uneven, and the pressing forces of different testers are also different, which is not conducive to testing the spraying effect of new products during the product R & D stage; Second, in terms of the evaluation of the spraying effect, due to the limitations of manually pressing the nasal spray, it is only limited to the tests of the spraying amount, the uniformity of the delivered dose, etc. of the nasal spray. Manual pressing cannot ensure the uniformity of the spraying pressure, resulting in unstable test results of the spraying performance, thus affecting the evaluation of the spraying effect, and the tests of the spray particle size, spray pattern and spray mode cannot be carried out, which greatly limits the comprehensive evaluation of the spraying performance of new products.

[0004] The present invention designs a mechanical trigger to replace manual pressing to trigger the nasal spray, which can provide a more uniform, stable, efficient and continuous triggering pressure, facilitating the comparative study of the spraying effects of new products with different batches and different structures; in terms of the evaluation of the spraying effect, in addition to the tests of the spraying amount and the uniformity of the delivered dose of the nasal spray, considering the uniformity of the force value for pressing the nasal spray and in cooperation with an image acquisition system and a laser particle size analyzer, the spray pattern (spray angle, spray width), spray mode (spray area), particle size distribution of the nasal spray can also be tested, which can greatly expand the test range of the spraying performance and promote the comprehensive evaluation of the spraying performance of new nasal spray products. The nasal spray trigger has important guiding significance for the development of new nasal sprays, the research on spray bottle materials and the R & D of nasal spray products, etc.

[0005] At present, there are very few reports and products on nasal spray triggers. In the world, only the Vereo series of automatic triggers developed by Proveris Company in the United States can be used for the automatic triggering of nasal sprays. This series of automatic triggers includes 4 different models, which are respectively used for the triggering of multi-dose nasal sprays, single-dose nasal sprays, single-side pressing nasal sprays and double-side pressing nasal sprays. Although this series of devices meets the FDA's regulatory requirements for triggers and can help achieve the automatic triggering of nasal spray and aerosol series tests, such as pre-spray, spray weight, connection to UDSA, sampling for spray uniformity test, etc., there are two problems. First, the functions of this series of nasal spray triggers are single, and it is impossible to achieve functions such as single-dose, multi-dose, single-side and double-side pressing at the same time. Therefore, for the determination of different types of nasal sprays, these four devices need to be configured at the same time, which is not only inconvenient to use but also too costly. Second, this series of devices is only developed and produced in the United States, and there is no precedent for research and development in China. Therefore, the price of this type of device is expensive, the cost performance is low, and it cannot be matched with domestic particle size testing devices. These problems have high costs, low efficiency and serious technical barriers in the research and development of domestic nasal sprays. There is an urgent need to design a triggering device that can be applied to various different types of nasal sprays, single-dose and multi-dose nasal sprays to promote the development of new nasal spray products. Summary of the Invention

[0006] The purpose of the present invention is to provide a device and method that can trigger different types of nasal sprays, providing data support for the research and application of nasal sprays.

[0007] In order to achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0008] In the first aspect, the present invention provides an automatic triggering device for nasal sprays, and the device includes a distribution box 1, a control system 2, a triggering system 3 and a sample loading system 4;

[0009] The distribution box 1 includes a chassis 11 and a power switch 12; the chassis 11 is used to protect the control system 2; the power switch 12 is connected to the switching power supply 22 of the control system 2, and the power switch 12 is used to control the power on and off;

[0010] The control system 2 is located inside the distribution box 1, and includes a power socket 21, a switching power supply 22, a DC power supply module 23, an electronic control mainboard 24, a host computer 25, a speed regulator 26 and a frequency regulator 27; wherein the host computer 25 includes a touch screen 251, an ADC analog-to-digital acquisition module 252, a DAC digital-to-analog output control conversion chip 253, and a communication chip 254, and the host computer 25 has a built-in host computer control software 255; the power socket 21 is used to connect to the mains, and the output end of the power socket 21 is connected to the input end of the switching power supply 22 to provide the switching power supply 22 with 220V. AC power; the output end of the switching power supply 22 is respectively connected to the input end of the DC power supply module 23 and the electronic control main board 24, and the switching power supply 22 is used to control the current input of the DC power supply module 23 and the electronic control main board 24; the output end of the DC power supply module 23 is respectively connected to the speed regulator 26, the frequency regulator 27 and the electromagnetic driver 31 to provide linear DC power; the electronic control main board 24 is respectively connected to the host computer 25, the speed regulator 26 and the frequency regulator 27 through data lines, the speed regulator 26 is connected to the electromagnetic driver 31 through a data line, and the frequency regulator 27 is connected to the gravity sensor 44 through a data line.

[0011] The trigger system 3 includes an electromagnetic driver 31, a trigger rod 32 and a bracket 33; the electromagnetic driver 31 includes a four-dimensional push rod 311, a four-dimensional coil 312 and a spring 313; the electromagnetic driver 31 provides a trigger thrust of 1-10kg, which is used to trigger and press nasal sprays of different shapes; the trigger rod 32 is located directly below the electromagnetic driver 31 and is spirally connected to the electromagnetic driver 31; the bracket 33 fixes the electromagnetic driver 31 and fixes the trigger system 3 to the sample loading system 4; the output generated by the trigger system 3 is sequentially converted through the ADC analog-to-digital acquisition module 252, the DAC digital-to-analog output control conversion chip 253, and the communication chip 254, and is presented on the host computer 25; the output of the trigger system 3 includes trigger pressure, trigger speed and trigger times;

[0012] The sample loading system 4 includes a fixing fixture 41, a fixing base 43, a gravity sensor 44, an adapter base 45, a lifting platform 46 and a spray bottle 410; the fixing fixture 41 radially fixes the spray bottle 410; the fixing base 43 is located below the fixing fixture 41 and is used to load the spray bottle 410; the gravity sensor 44 is located below the fixing base 43 and contacts the bottom end of the spray bottle 410 to sense the triggering pressure on the spray bottle 410; the adapter base 45 connects the fixing base 43 with the lifting platform 46;

[0013] The host computer 25 is built-in with host computer control software 255 to control and set control parameters through the touch screen 251. The parameters are transmitted to the electronic control main board 24 through the host computer control software 255. The electronic control main board 24 controls the speed governor 26 to adjust the electromagnetic driver 31. The electromagnetic driver 31 drives the trigger rod 32 to trigger the push button of the nasal spray bottle according to the control parameters. The gravity sensor 44 senses the triggered pressure and transmits the data information back to the electronic control main board 24 through the frequency modulator 27, and then the electronic control main board 24 transmits it to the host computer 25.

[0014] Preferably, the power switch 12 is embedded in the surface of the chassis 11. An installation position for the host computer 25 is reserved above the front of the chassis 11, and an installation position for the power socket 21 is reserved below the back of the chassis 11.

[0015] Preferably, the bracket 33 includes a left bracket 331, a right bracket 332 and a top plate 333. The top plate 333 is fixedly connected to the top of the electromagnetic driver 31. The left bracket 331 and the right bracket 332 are respectively located on the left and right sides of the top plate 333. The tops of the left bracket 331 and the right bracket 332 fix the electromagnetic driver 31 from the left and right sides, and the bottoms of the left bracket 331 and the right bracket 332 are respectively fixed to the chassis 49 of the sample loading system 4.

[0016] Preferably, the sample loading system 4 is further provided with a lifting knob 47, a lifting frame 48 and a chassis 49. A lifting knob 47 is installed directly below the lifting platform 46. By rotating the lifting knob 47, the height displacement of the lifting frame 48 is controlled to adjust the height position of the lifting platform 46. The chassis 49 is fixed to the bottom end of the lifting frame 48 to stabilize the lifting frame 48.

[0017] Preferably, the sample loading system 4 is further provided with a fixing screw 42. The fixing screw 42 is located on one side of the fixing clamp 41, and different degrees of fastening of the fixing clamp 41 are achieved by adjusting the tightness of the fixing screw 42.

[0018] Preferably, the data real-time output or graphical display of the trigger system 3 and the sample loading system 4 are shown on the touch screen 251 of the host computer 25.

[0019] Preferably, the parameters set by the host computer control software 255 include pressure, number of presses, and pressing speed.

[0020] Preferably, the output end of the switching power supply 22 provides 0 - 30V direct current for the DC power supply module 23 and the electronic control main board 24.

[0021] Preferably, the DC power supply module 23 provides 24V linear direct current for the speed governor 26, the frequency modulator 27 and the electromagnetic driver 31.

[0022] In a second aspect, the present invention provides a method for using the automatic triggering device of the nasal spray described in the first aspect, specifically including the following steps:

[0023] S1: First, connect and install the four parts of the distribution box 1, the control system 2, the triggering system 3, and the sample loading system 4 in sequence.

[0024] S2: Place the spray bottle 410 to be tested on the fixed base 43, adjust the fixed fixture 41 to fix the spray bottle 410, adjust the direction of the liquid spraying port, and adjust the lifting platform 46 to a suitable working height.

[0025] S3: Set the parameters of the host computer control software 255 through the touch screen 251.

[0026] S4: Place the nasal spray ejection port in the particle size test area, start the test, and the control system 2 adjusts the triggering system 3 according to the control parameters to trigger the nasal spray and capture relevant data.

[0027] Advantages of the present invention:

[0028] On the one hand, the present invention converts different voltages into corresponding triggering thrusts through an electromagnetic driver. On the other hand, a gravity sensor is configured to detect the triggering thrust acting on the nasal spray in real time and feedback it to the control system, and then precisely adjust the voltage of the electromagnetic driver, thereby ensuring the accuracy of the triggering force and being able to control the size of the triggering force through software.

[0029] The present invention matches fixed fixtures of different shapes through the sample loading system to realize the spray performance test of nasal sprays of different shapes, single-dose or multi-dose nasal sprays, including the spray performance tests such as spray volume, delivery dose uniformity, spray pattern, spray morphology, particle size distribution, etc. under different triggering conditions such as different triggering pressures and different spraying directions, so as to further guide the design and use of diversified nasal sprays.

[0030] The present invention can also be used in combination with various models of laser particle size instruments to realize the test of a wide range of spray particle sizes. It has the characteristics of convenient operation and strong practicability, can greatly expand the spray performance test range, and promote the comprehensive evaluation of the spray performance of new nasal spray products. Description of the Drawings

[0031] In order to more clearly illustrate the technical solutions of the specific embodiments of the present invention, the following will briefly describe the drawings required for use in the description of the specific embodiments. It should be understood that the following drawings only show some embodiments of the present invention, and therefore should not be regarded as limiting the scope. For those of ordinary skill in the art, other related drawings can also be obtained based on these drawings without creative efforts.

[0032] Figure 1Automatic Trigger Device for Nasal Spray

[0033] In the figure: 1. Distribution box, 2. Control system, 3. Trigger system, 4. Sample-carrying system

[0034] Figure 2 Structure Diagram of Distribution Box

[0035] In the figure: 11. Chassis, 12. Power switch

[0036] Figure 3 Structure Diagram of Control System

[0037] In the figure: 21. Power socket, 22. Switching power supply, 23. DC power supply module, 24. Electronic control main board, 25. Host computer, 26. Speed governor, 27. Frequency modulator

[0038] Figure 4 Structure Diagram of Host Computer

[0039] In the figure: 251. Touch screen, 252. ADC analog-digital acquisition module, 253. DAC digital-analog output control conversion chip, 254. Communication chip, 255. Host computer control software

[0040] Figure 5 Structure Diagram of Trigger System

[0041] In the figure: 31. Electromagnetic driver, 32. Trigger rod, 33. Bracket

[0042] Figure 6 Structure Diagram of Electromagnetic Driver

[0043] In the figure: 311. Four-dimensional push rod, 312. Four-dimensional coil, 313. Spring

[0044] Figure 7 Structure Diagram of Bracket

[0045] In the figure: 331. Left side frame, 332. Right side frame, 333. Top plate

[0046] Figure 8 Structure Diagram of Sample-carrying System

[0047] In the figure: 41. Fixed fixture, 42. Fixed screw, 43. Fixed base, 44. Gravity sensor, 45. Adapter base, 46. Lifting platform, 47. Lifting knob, 48. Lifting frame, 49. Chassis, 410. Spray bottle Specific Embodiment

[0048] Embodiment 1

[0049] Such as Figures 1 to 7As shown in the figure, an automatic triggering device for nasal spray consists of four parts: a distribution box 1, a control system 2, a triggering system 3, and a sample-carrying system 4. The four parts are connected in sequence.

[0050] As Figure 1 shown in the figure, the distribution box 1 consists of a chassis 11 and a power switch 12. The power switch 12 is embedded in the surface of the chassis 11. Above the front of the chassis 11, a mounting position for the host computer 25 is reserved, and below the back of the chassis 11, a mounting position for the power socket 21 is reserved. The chassis 11 is used to protect the control system; the power switch 12 is connected to the switching power supply 22 of the control system 2, and the power switch 12 is used to control the power on and off.

[0051] As Figure 2 shown in the figure, the control system 2 is installed inside the distribution box 1 and includes a power socket 21, a switching power supply 22, a DC power supply module 23, an electronic control main board 24, a host computer 25, a speed governor 26, and a frequency modulator 27. The power socket 21 is used to connect to the mains. The output end of the power socket 21 is connected to the input end of the switching power supply 22 to provide 220V alternating current for the switching power supply 22; the output ends of the switching power supply 22 are respectively connected to the input end of the DC power supply module 23 and the electronic control main board 24 to provide 0 - 30V direct current for them. The switching power supply 22 is used to control the current input of the DC power supply module 23 and the electronic control main board 24; the DC power supply module 23 adopts a linear DC voltage digital control module, and its output ends are respectively connected to the speed governor 26, the frequency modulator 27, and the electromagnetic driver 31 to provide 24V linear direct current for them, with the characteristics of smooth control and fast response; the electronic control main board 24 is connected to the host computer 25, the speed governor 26, and the frequency modulator 27 through data lines respectively. Its data processing unit is an AVR industrial control platform, and the processor model is: Atmega128AU, which adopts a RISC single instruction set, has a fast response speed, and strong industrial anti-interference ability; the speed governor 26 is connected to the electromagnetic driver 31 through a data line, and the frequency modulator 27 is connected to the gravity sensor 44 through a data line. In order to be able to stably control the operation of the triggering device, the host computer control software 255 is used to operate and control the pressure, triggering speed, and triggering times of the nasal spray trigger, and together with the ADC analog-to-digital acquisition module 252, the DAC digital-to-analog output control conversion chip 253, and the communication chip 254, it forms a host computer control module. As Figure 3 shown in the figure, the touch screen 251 is used to operate the host computer control software 255 to realize the real-time control of the nasal spray triggering device and the real-time monitoring of data.

[0052] As Figure 4 shown in the figure, the triggering system 3 includes an electromagnetic driver 31, a triggering rod 32, and a bracket 33. Among them, as Figure 5As shown in the figure, the electromagnetic driver 31 is composed of a four-dimensional push rod 311, a four-dimensional coil 312 and a spring 313. It is a through-type 24V electromagnetic driver that can provide a trigger thrust of 1-10 kg. The instantaneous response time can reach 100 ms, and it can realize the trigger pressing of nasal sprays with different shapes; the trigger rod 32 is located directly below the electromagnetic driver 31 and is helically connected to the electromagnetic driver 31. Different specifications of trigger rod heads can be replaced according to the shape of the spray bottle and the trigger method; as Figure 6 As shown in the figure, the bracket 33 is composed of a left bracket 331, a right bracket 332 and a top plate 333. The top plate 333 is used to fix the electromagnetic driver 31 from the top. The left bracket 331 and the right bracket 332 are respectively located on the left and right sides of the top plate 333. The tops of the left bracket 331 and the right bracket 332 fix the electromagnetic driver 31 from the left and right sides, and the bottoms of the left bracket 331 and the right bracket 332 are respectively fixed on the chassis 49 of the sample loading system 4. Through the bracket 33, the trigger system 3 is firmly connected to the sample loading system 4.

[0053] As Figure 7 As shown in the figure, the sample loading system 4 includes a fixed clamp 41, a fixing screw 42, a fixed base 43, a gravity sensor 44, an adapter base 45, a lifting platform 46, a lifting knob 47, a lifting frame 48, a chassis 49, and a spray bottle 410. The fixing screw 42 is located on one side of the fixed clamp 41, and the fixing degree of the fixed clamp 41 can be adjusted by adjusting the tightness of the fixing screw 42; the fixed clamp 41 is used to radially fix the spray bottle 410; the fixed base 43 is located below the fixed clamp 41 and is used to load the spray bottle 410; the gravity sensor 44 is located below the fixed base 43 and contacts the bottom end of the spray bottle 410, and is used to sense the trigger pressure received by the spray bottle 410. It uses a high-precision planar tension and compression circular weight sensor with a weighing range of 0-10 kg and a repeatability accuracy of 0.3%; the adapter base 45 is used to connect the fixed base 43 and the lifting platform 46; a lifting knob 47 is installed directly below the lifting platform 46, and the height displacement of the lifting frame 48 is controlled by rotating the lifting knob 47 to realize the adjustment of the height position of the lifting platform 46; the chassis 49 is fixed to the bottom end of the lifting frame 48 to stabilize the lifting frame 48.

[0054] In use, turn on the power switch 12 to connect the power supply, and operate the host computer control software 255 through the touch screen 251 to start the system operation. When the system is running, first set the control parameters through the touch screen 251. The parameters are transmitted to the electronic control main board 24 through the host computer control software 255. The electronic control main board 24 controls the speed governor 26 to adjust the electromagnetic driver 31. The electromagnetic driver 31 drives the trigger rod 32 to trigger the push button of the nasal spray bottle according to the control parameters. The gravity sensor 44 senses the triggered pressure and transmits the data information back to the electronic control main board 24 through the frequency modulator 27, and then the electronic control main board 24 transmits it to the host computer 25; the action outputs such as the trigger pressure, trigger speed and trigger times generated by the trigger system 3 are sequentially converted by the ADC analog-digital acquisition module 252, the DAC digital-analog output control conversion chip 253, and the communication chip 544, and then the data is output in real time and graphically displayed on the touch screen 251 of the host computer 25.

[0055] Example 2

[0056] Single-dose, multi-dose and unilateral / bilateral pressing tests of nasal sprays:

[0057] Connect the trigger device according to the method of Example 1, and replace the trigger rod head according to the trigger mode of the nasal spray. When the trigger mode is unilateral pressing, select a single head, and when the trigger mode is bilateral pressing, select a double head. Place the nasal spray to be tested on the fixed base 43, tighten the fixing screw 42 to adjust the fixing fixture 41 to fix the nasal spray, and control the lifting frame 48 through the lifting knob 47 to adjust the lifting platform 46 to a suitable use height, and adjust the liquid spraying direction. When performing a single-dose trigger, select the manual trigger mode through the touch screen 251, set the pressing pressure to 1-10 kg, and click the <Trigger> button on the host computer control software 255 through the touch screen 251. The control system 2 adjusts the trigger system 3 according to the control parameters to perform a single-dose nasal spray trigger; when performing a multi-dose trigger, select the automatic trigger mode through the touch screen 251, set the pressing pressure to 1-10 kg, the number of presses and the interval time, and click the <Trigger> button on the host computer control software 255 through the touch screen 251. The control system 2 adjusts the trigger system 3 according to the control parameters to perform a multi-dose nasal spray trigger.

[0058] Example 3

[0059] Delivery dose uniformity test of nasal sprays:

[0060] Connect the triggering device according to the method of Embodiment 1. After weighing with a precision electronic balance, place the nasal spray to be tested on the fixed base 43, tighten the fixing screw 42 to adjust the fixing clamp 41 to fix the nasal spray; control the lifting frame 48 through the lifting knob 47 to adjust the lifting platform 46 to a suitable working height, and adjust the liquid spraying direction; select the manual triggering mode through the touch screen 251 and set the pressing pressure to 1 - 10 kg; click the <Trigger> button on the host computer control software 255 through the touch screen 251, and the control system 2 will adjust the triggering system 3 according to the control parameters to trigger the nasal spray; after each spray, weigh with a precision electronic balance, and calculate the reduced weight of the nasal spray as the single spray volume. Examine the delivery dose uniformity according to the change of the single spray volume. As can be seen from the following table, the automatic triggering device for nasal sprays can test the delivery dose of the spray, and the spray volume is relatively uniform.

[0061] Table 1. Test of the delivery dose of the spray

[0062]

[0063] Embodiment 4

[0064] Analysis of the spray particle size distribution of nasal sprays:

[0065] Connect the triggering device according to the method of Embodiment 1. Place the nasal spray to be tested on the fixed base 43, tighten the fixing screw 42 to adjust the fixing clamp 41 to fix the nasal spray; control the lifting frame 48 through the lifting knob 47 to adjust the lifting platform 46 to a suitable working height, and adjust the liquid spraying direction so that it is within the test area of the laser spray particle size analyzer; select the automatic triggering mode through the touch screen 251 and set the pressing pressure to 1 - 10 kg, the number of presses and the interval time; click the <Trigger> button on the host computer control software 255 through the touch screen 251, and the control system 2 will adjust the triggering system 3 according to the control parameters to automatically trigger the nasal spray, and use the laser spray particle size analyzer to collect and analyze the spray particle size distribution. As can be seen from Table 2, the automatic triggering device for nasal sprays combined with the laser particle size analyzer can test the particle size of the spray in real time, and the spray particle size is relatively uniform.

[0066] Table 2. Test of the spray particle size of nasal sprays

[0067]

Claims

1. A nasal spray automatic trigger device, characterized in that: The device comprises a distribution box (1), a control system (2), a trigger system (3) and a sample loading system (4); The distribution box (1) comprises a chassis (11) and a power switch (12); the chassis (11) is used to protect the control system (2); the power switch (12) is connected to a switching power supply (22) of the control system (2), and the power switch (12) is used to control the power on and off of the machine; The control system (2) is located inside the distribution box (1), and comprises a power socket (21), a switching power supply (22), a DC power supply module (23), an electric control mainboard (24), a host computer (25), a speed regulator (26) and a frequency modulator (27); wherein the host computer (25) comprises a touch screen (251), an ADC analog-to-digital acquisition module (252), a DAC digital-to-analog output control conversion chip (253), and a communication chip (254); the host computer (25) has a built-in host computer control software (255); the output end of the power socket (21) is connected to the input end of the switching power supply (22) to provide alternating current to the switching power supply (22); the switching power supply The output end of the switch power supply (22) is respectively connected to the input end of the DC power supply module (23) and the electric control main board (24), and the switch power supply (22) is used to control the current input of the DC power supply module (23) and the electric control main board (24); the output end of the DC power supply module (23) is respectively connected to the speed regulator (26), the frequency regulator (27) and the electromagnetic driver (31) to provide linear DC power; the electric control main board (24) is respectively connected to the host computer (25), the speed regulator (26) and the frequency regulator (27) through data lines, the speed regulator (26) is connected to the electromagnetic driver (31) through a data line, and the frequency regulator (27) is connected to the gravity sensor (44) through a data line; The trigger system (3) comprises an electromagnetic driver (31), a trigger rod (32) and a bracket (33); the electromagnetic driver (31) comprises a four-dimensional push rod (311), a four-dimensional coil (312) and a spring (313); the electromagnetic driver (31) provides a trigger thrust to achieve a trigger pressing of the nasal spray push and twist; the trigger rod (32) is located directly below the electromagnetic driver (31) and is spirally connected to the electromagnetic driver (31); the bracket (33) fixes the electromagnetic driver (31) and fixes the trigger system (3) to the sample loading system (4); the output generated by the trigger system (3) is sequentially converted through the ADC analog-to-digital acquisition module (252), the DAC digital-to-analog output control conversion chip (253) and the communication chip (254) and presented on the host computer (25); the output of the trigger system (3) includes a trigger pressure, a trigger speed and a trigger number; The sample loading system (4) comprises a fixing fixture (41), a fixing base (43), a gravity sensor (44), an adapter base (45), a lifting platform (46) and a spray bottle (410); the fixing fixture (41) radially fixes the spray bottle (410); the fixing base (43) is located below the fixing fixture (41) and is used to load the spray bottle (410); the gravity sensor (44) is located below the fixing base (43) and is in contact with the bottom end of the spray bottle (410) and is used to sense the triggering pressure applied to the spray bottle (410); the adapter base (45) connects the fixing base (43) and the lifting platform (46); The host computer (25) has a built-in host computer control software (255) which controls and sets control parameters through a touch screen (251). The parameters are transmitted to the electric control main board (24) via the host computer control software (255). The electric control main board (24) controls the speed regulator (26) to adjust the electromagnetic driver (31). The electromagnetic driver (31) drives the trigger rod (32) to trigger the push and twist of the nasal spray bottle according to the control parameters. The gravity sensor (44) senses the triggering pressure and transmits the data information back to the electric control main board (24) via the frequency modulator (27). The electric control main board (24) then transmits the data to the host computer (25).

2. The automatic triggering device for nasal spray according to claim 1, characterized in that: The power switch (12) is embedded in the surface of the chassis (11), a mounting position for the host computer (25) is reserved above the front of the chassis (11), and a mounting position for the power socket (21) is reserved below the back of the chassis (11).

3. The automatic triggering device for nasal spray according to claim 1, characterized in that: The bracket (33) includes a left side frame (331), a right side frame (332) and a top plate (333); the top plate (333) is fixedly connected to the top of the electromagnetic driver (31); the left side frame (331) and the right side frame (332) are respectively located on the left and right sides of the top plate (333); the top ends of the left side frame (331) and the right side frame (332) fix the electromagnetic driver (31) from the left and right sides; the bottom ends of the left side frame (331) and the right side frame (332) are respectively fixed to the chassis (49) of the sample loading system (4).

4. The automatic triggering device for nasal spray according to claim 1, characterized in that: The sample loading system (4) is also provided with a lifting knob (47), a lifting frame (48), and a chassis (49); a lifting knob (47) is installed directly below the lifting platform (46), and the height displacement of the lifting frame (48) is controlled by rotating the lifting knob (47), thereby adjusting the height position of the lifting platform (46); the chassis (49) is fixed to the bottom end of the lifting frame (48) to stabilize the lifting frame (48).

5. The automatic triggering device for nasal spray according to claim 1, characterized in that: The sample loading system (4) is further provided with a fixing screw (42); the fixing screw (42) is located on one side of the fixing fixture (41), and the fixing fixture (41) can be tightened to different degrees by adjusting the tightness of the fixing screw (42).

6. The automatic triggering device for nasal spray according to claim 1, characterized in that: The touch screen (251) of the host computer (25) displays the data of the trigger system (3) and the sample loading system (4) in real-time output or graphical display.

7. The automatic triggering device for nasal spray according to claim 1, characterized in that: The host computer control software (255) sets parameters including pressure, number of pressing times, and pressing speed.

8. The automatic triggering device for nasal spray according to claim 1, characterized in that: The output end of the switching power supply (22) provides 0-30V direct current to the direct current power supply module (23) and the electric control mainboard (24).

9. The automatic triggering device for nasal spray according to claim 1, characterized in that: The DC power supply module (23) provides 24V linear DC power to the speed regulator (26), the frequency regulator (27) and the electromagnetic driver (31).

10. A method for using the automatic triggering device for nasal spray according to any one of claims 1 to 9, characterized in that: The specific steps are as follows: S1: First, the four parts of the distribution box (1), the control system (2), the trigger system (3) and the sample loading system (4) are connected and installed in sequence; S2: placing the spray bottle (410) to be tested on the fixed base (43), adjusting the fixing fixture (41) to fix the spray bottle (410), adjusting the direction of the liquid spraying port, and adjusting the lifting platform (46) to a suitable height for use; S3: Setting the parameters of the host computer control software (255) through the touch screen (251); S4: placing the nasal spray outlet in the particle size test area, starting the test, and the control system (2) adjusting the trigger system (3) according to the control parameters to trigger the nasal spray and capture related data.

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