Contact lens composition and contact lens maintenance method

Abstract

The invention discloses a composition for contact lenses and a maintenance method of the contact lenses, and the composition for the contact lenses comprises a freshener and a surfactant, wherein the surfactant comprises one or a combination of more of sodium lauroyl lactate, polyoxyethylene laureth sulfate, polyoxypropylene glycol, polyoxyethylene hardened castor oil, polyvinylpyrrolidone, lauryl sodium sulfate, polyoxyethylene sorbitan monooleate and alkyl sulfosuccinate. Therefore, the wearing comfort of the contact lenses can be effectively improved.

Description

[0001] This application is a divisional application of an invention patent application with an application date of April 12, 2017, application number 201710237450.6, and invention name “Composition for contact lenses and method for maintaining contact lenses”. Technical Field

[0002] The present invention relates to a contact lens composition, in particular to a contact lens composition used as a contact lens storage packaging liquid. The present invention further relates to a contact lens maintenance method. Background Art

[0003] With the advent of the information age, the extensive use of computers and smart phones has not only led to a rising rate of myopia, but also a decreasing trend in the age group of myopia. Considering the convenience and aesthetics, contact lenses are a very valuable choice. However, most people with poor eyesight have the habit of wearing contact lenses for a long time. Even though the materials of existing contact lenses have been continuously improved to meet various needs (such as high water content, high oxygen permeability, etc.), users still feel dry eyes due to the reduction of water content in the lenses, and feel eye discomfort (such as itching, stinging, etc.) due to dirt and sediment on the lenses. Therefore, there is an urgent need for a maintenance solution that can clean, re-moisten and preserve contact lenses. Summary of the invention

[0004] The technical problem to be solved by the present invention is to provide a contact lens composition and a contact lens maintenance method to address the deficiencies of the prior art, so that users can keep their eyes comfortable when they first wear contact lenses and when they wear them continuously for a long time.

[0005] In order to solve the above technical problems, a technical solution adopted by the present invention is to provide a composition for contact lenses, characterized in that the composition for contact lenses comprises a cooling agent and a surfactant, and the surfactant comprises a combination of one or more of sodium lauroyl lactylate, polyoxyethylene lauryl alcohol polyether sulfate, polyoxypropylene glycol, polyoxyethylene hardened castor oil, polyvinyl pyrrolidone, sodium lauryl sulfate, polyoxyethylene sorbitan monooleate and alkyl sulfosuccinate.

[0006] In order to solve the above technical problems, another technical solution adopted by the present invention is to provide a method for maintaining contact lenses, which comprises the following steps: providing a liquid composition, which comprises a cooling agent and a surfactant, wherein the surfactant comprises a combination of one or more of sodium lauroyl lactylate, polyoxyethylene lauryl alcohol polyether sulfate, polyoxypropylene glycol, polyoxyethylene hardened castor oil, polyvinyl pyrrolidone, sodium lauryl sulfate, polyoxyethylene sorbitan monooleate and alkyl sulfosuccinate; and fully contacting the liquid composition with the lens surface of the contact lens.

[0007] Preferably, the content of the surfactant is between 0.001% (w / v) and 0.5% (w / v).

[0008] Preferably, the cooling agent comprises a combination of one or more of menthol, camphor, borneol, menthyl lactate, menthone glycerol ketal, monomenthyl succinate and p-menthane-3,8-diol.

[0009] Preferably, the cooling agent is menthol.

[0010] Preferably, the content of the cooling agent is between 0.001% (w / v) and 0.25% (w / v).

[0011] Preferably, the liquid composition further comprises a water-soluble polymer, and the water-soluble polymer comprises a combination of one or more of polyethylene glycol, methyl acrylate phosphorylcholine and hyaluronic acid.

[0012] Preferably, the water-soluble polymer comprises polyethylene glycol (molecular weight PEG400) and methyl acrylate phosphorylcholine, and the weight ratio of polyethylene glycol to methyl acrylate phosphorylcholine is 1:20.

[0013] Preferably, the content of the water-soluble polymer is between 0.05% (w / v) and 5% (w / v).

[0014] Preferably, the liquid composition further comprises a buffer comprising boric acid and sodium tetraborate.

[0015] The beneficial effect of the present invention lies in that the contact lens composition provided by the technical solution of the present invention is used in combination with a cooling agent and a surfactant, wherein the surfactant comprises a combination of one or more of sodium lauroyl lactylate, polyoxyethylene lauryl alcohol polyether sulfate, polyoxypropylene glycol, polyoxyethylene hardened castor oil, polyvinyl pyrrolidone, sodium lauryl sulfate, polyoxyethylene sorbitan monooleate and alkyl sulfosuccinate, which can better exert the effect of the cooling agent, eliminate or relieve the discomfort and foreign body sensation of the eyes of the contact lens wearer, and maintain the eyes in a lubricated, moist and cool state for a long time.

[0016] To further understand the features and technical contents of the present invention, please refer to the following detailed description and drawings of the present invention. However, the drawings provided are only for reference and description and are not intended to limit the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the use of the contact lens composition of the present invention.

[0018] Figure 2It is a schematic flow chart of the contact lens maintenance method of the present invention. DETAILED DESCRIPTION

[0019] The following is an explanation of the embodiments of the "composition for contact lenses" disclosed in the present invention through specific embodiments. Those skilled in the art can understand the advantages and effects of the present invention from the contents disclosed in this specification. The present invention can be implemented or applied through other different specific embodiments, and the details in this specification can also be modified and changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention. In addition, the drawings of the present invention are only simple schematic illustrations and are not depicted according to actual sizes. It is stated in advance. The following embodiments will further explain the relevant technical contents of the present invention in detail, but the disclosed contents are not intended to limit the scope of protection of the present invention.

[0020] Reference Figure 1 The contact lens composition provided in the embodiment of the present invention can be used as a contact lens preservation solution and can be placed in a sealed packaging container together with a contact lens. In practical applications, the contact lens is immersed in the composition to maintain full contact with the composition until the user wants to wear the contact lens, then the contact lens is taken out of the composition and worn on the eyeball. More specifically, when the contact lens is immersed in the composition, the components in the composition will be adsorbed on the contact lens, and once the contact lens is moved and attached to the eyeball, the components will enter the eyeball.

[0021] The contact lens composition provided in the embodiment of the present invention is applicable to both soft contact lenses and hard contact lenses, wherein the soft contact lenses can be aqueous soft contact lenses (hydrogel contact lenses) using hydrogels, or non-aqueous soft contact lenses using copolymers of butyl acrylate and butyl methacrylate. More specifically, the contact lens composition of the present invention is applicable to any one of Groups I to IV classified by the U.S. Food and Drug Administration (FDA): alphafilcon, asmofilcon, balafilcon, ethafilcon, hefilcon, hilafilcon, lidofilcon, lotrafilcon, methafilcon, nelfilcon, ocufilcon, omafilcon, phemfilcon, polymacon, tefilcon, tetrafilcon, vasurfilcon, vifilcon, senofilcon, galyfilcon, enfilcon, comfilcon, narafilcon, delefilcon, efrofilcon, FILICON II 3, etc.

[0022] The contact lens composition provided by the embodiment of the present invention mainly comprises a liquid matrix and a cooling agent, a surfactant and a water-soluble polymer uniformly dispersed in the liquid matrix.

[0023] In this embodiment, the liquid matrix can be selected from physiological saline containing a boric acid buffer or a phosphate buffer, wherein the boric acid buffer and the phosphate buffer have a pH buffering effect to adjust the pH value of the composition of the present invention to a range of about 6.8 to 7.6; in addition, the liquid matrix can contain an appropriate amount of sodium chloride or potassium chloride to maintain the osmotic pressure of the composition of the present invention within a range of about 250 Osmol / Kg to 350 Osmol / Kg.

[0024] The boric acid buffer may be boric acid or a borate (such as sodium tetraborate), and the phosphate buffer may be phosphoric acid or a phosphate (such as sodium monohydrogen phosphate, sodium dihydrogen phosphate, etc.); it should be noted that a single buffer may be used alone in the liquid matrix, or two or more different buffers may be used in combination, and the concentration of the buffer may be appropriately adjusted according to the type of buffer used or the type of other ingredients.

[0025] The cooling agent is added to eliminate or relieve the discomfort and foreign body sensation of the eyes and give the eyes a cooling feeling. The cooling agent comprises a combination of one or more of menthol, camphor, borneol, menthyl lactate, menthone-glycerol ketal, monomethyl succinate and p-menthane-3,8-doil. The content of the cooling agent may be between 0.001% (w / v) and 0.5% (w / v), and preferably between 0.001% (w / v) and 0.25% (w / v) to avoid excessive irritation to the eyeball.

[0026] Surfactants are added to clean contact lenses to remove grease, sludge, etc. on the lenses and improve the lubricity and wettability of contact lenses. Surfactants include sodium lauroyllactylate, polyoxyethylene laureth sulfate, polyoxypropylene glycol, polyoxyethylene hardened castor oil, polyvinyl pyrrolidone (PVP), sodium dodecyl sulfate (SDS), polyoxyethylene sorbitan monooleate (TWEEN 80 TM ) and alkyl sulfosuccinates (GEROPONTM SBFA-30), the content of the surfactant may be between 0.001% (w / v) and 2% (w / v), and preferably between 0.001% (w / v) and 0.5% (w / v).

[0027] It is worth noting that the present invention selects specific surfactants for use in combination with cooling agents, which can better exert the effect of cooling agents. For example, cooling agents can effectively relieve symptoms such as eye fatigue, dryness, itching and pain, and can maintain the cooling feeling of the eyes for a long time.

[0028] The addition of water-soluble polymers helps lubricate and moisturize contact lenses. In addition, water-soluble polymers also help retain eye-friendly ingredients in the composition on contact lenses. For example, if the composition contains vitamins (such as vitamin A, vitamin B, vitamin E, etc.), the water-soluble polymers can interact with the vitamins to increase the adsorption of the vitamins while preventing the vitamins from being lost quickly. The water-soluble polymers include one or more combinations of polyethylene glycol (molecular weight PEG400), methyl acrylate phosphorylcholine (MPC), and hyaluronic acid. The best combination is to use polyethylene glycol and methyl acrylate phosphorylcholine at the same time and add them at a weight ratio of 1:20. The content of the water-soluble polymer can be between 0.002% (w / v) and 10% (w / v), and preferably between 0.05% (w / v) and 5% (w / v).

[0029] Reference Figure 2 Based on the above-mentioned contact lens composition, the present invention further provides a method for maintaining contact lenses. Figure 2 As shown, the method for maintaining contact lenses S100 first performs step S102 to provide a liquid composition, which includes a cooling agent and a surfactant, wherein the surfactant includes a combination of one or more of sodium lauroyl lactylate, polyoxyethylene lauryl alcohol polyether sulfate, polyoxypropylene glycol, polyoxyethylene hardened castor oil, polyvinyl pyrrolidone, sodium lauryl sulfate, polyoxyethylene sorbitan monooleate, and alkyl sulfosuccinate. Then, step S104 is performed to fully contact the liquid composition with the lens surface of the contact lens.

[0030] The term "contact" used herein may be contact achieved by immersing the contact lens in the liquid composition or by rinsing the contact lens with the liquid composition.

[0031] Evaluation Project

[0032] Table 1 lists several representative examples and comparative examples. The contact lens compositions of the examples and comparative examples were used to fully contact contact lenses, respectively. The lubricity, comfort, coolness and moistness were evaluated using the VAS method (Visual Analogue Scale) immediately after wearing the contact lenses and 30 minutes and 1 hour after wearing them. The average score of 3 people (6 eyes) was calculated for each evaluation item. The results are shown in Table 2.

[0033] Table 1

[0034]

[0035] Table 2

[0036]

[0037] Advantageous Effects of Embodiments

[0038] The contact lens composition provided in the embodiment of the present invention is used by combining a cooling agent with a surfactant, wherein the surfactant comprises sodium lauroyl lactylate, polyoxyethylene laureth sulfate, polyoxypropylene glycol, polyoxyethylene hardened castor oil, polyvinyl pyrrolidone (PVP), sodium dodecyl sulfate (SDS), polyoxyethylene sorbitan monooleate (TWEEN 80 TM ) and alkyl sulfosuccinates (GEROPON TM SBFA-30) can better exert the effect of the cooling agent, eliminate or relieve the discomfort and foreign body sensation in the eyes of contact lens wearers, and keep the eyes lubricated, moist and cool for a long time.

[0039] The contents disclosed above are only preferred feasible embodiments of the present invention, and are not intended to limit the protection scope of the claims of the present invention. Therefore, equivalent technical changes made using the contents of the present invention description and drawings are all included in the protection scope of the claims of the present invention.

Claims

1. A contact lens composition, characterized in that: The contact lens composition comprises: A cooling agent; wherein the cooling agent comprises one or a combination of two or more of menthol, camphor, borneol, menthyl lactate, menthone glycerol ketal, monomenthyl succinate and p-menthane-3,8-diol; Surfactant; wherein the surfactant comprises one or a combination of two or more of sodium lauroyl lactylate, polyoxyethylene lauryl alcohol polyether sulfate, polyoxypropylene glycol, polyvinyl pyrrolidone, sodium lauryl sulfate, polyoxyethylene sorbitan monooleate and alkyl sulfosuccinate; and Water-soluble polymer; wherein the water-soluble polymer comprises one or a combination of two or more of polyethylene glycol, methyl acrylate phosphorylcholine and hyaluronic acid.

2. The contact lens composition according to claim 1, wherein The water-soluble polymer comprises both polyethylene glycol and methyl acrylate phosphorylcholine.

3. The contact lens composition according to claim 2, characterized in that The content of the water-soluble polymer is between 0.002% (w / v) and 10% (w / v).

4. The contact lens composition according to claim 3, characterized in that The weight ratio of the polyethylene glycol to the methyl acrylate phosphorylcholine is 0-50:0-50.

5. The contact lens composition according to claim 3, characterized in that The weight ratio of the polyethylene glycol to the methyl acrylate phosphorylcholine is 1:

20.

6. The contact lens composition according to claim 5, characterized in that The molecular weight of the polyethylene glycol is 400.

7. The contact lens composition according to claim 1, wherein The surfactant is selected from at least one of the following material groups: polyoxyethylene sorbitan monooleate, polyvinyl pyrrolidone, and alkyl sulfosuccinate, and the surfactant does not include polyoxyethylene hardened castor oil.

8. The contact lens composition according to claim 1, wherein The surfactant is selected from at least two or more of the following material group: polyoxyethylene sorbitan monooleate, polyvinyl pyrrolidone and alkyl sulfosuccinate, and the surfactant does not include polyoxyethylene hardened castor oil.

9. The contact lens composition according to claim 1, wherein The surfactant is composed of the following two materials: polyoxyethylene sorbitan monooleate and polyvinyl pyrrolidone, and the weight ratio is 0.01-5:0.01-5.

10. The contact lens composition according to claim 1, wherein The surfactant is composed of the following three materials: polyoxyethylene sorbitan monooleate, polyvinyl pyrrolidone and alkyl sulfosuccinate, and the weight ratio is 0.01-5:0.01-5:0.01-5.

11. The contact lens composition according to claim 1, wherein The surfactant is composed of the following two materials: polyvinyl pyrrolidone and alkyl sulfosuccinate, and the weight ratio is 0.01-5:0.01-5.

12. The contact lens composition according to claim 1, wherein The content of the surfactant is between 0.001% and 2% (w / v), and the content of the water-soluble polymer is between 0.002% and 10% (w / v).

13. The contact lens composition according to claim 1, wherein The content of the cooling agent is between 0.001% and 0.25% (w / v), the content of the surfactant is between 0.001% and 0.5% (w / v), and the content of the water-soluble polymer is between 0.05% and 5% (w / v).

14. The contact lens composition according to claim 1, wherein The cooling agent is menthol.

15. The contact lens composition according to claim 1, wherein The contact lens composition further includes a buffer, and the buffer includes sodium chloride, boric acid, and sodium tetraborate.

16. The contact lens composition according to claim 15, characterized in that The weight ratio of the sodium chloride, the boric acid and the sodium tetraborate is 10-20:8-16:0.5-4.

5.

17. A method for maintaining contact lenses, characterized in that: The maintenance method of the contact lens comprises the following steps: Provided is a contact lens composition according to any one of claims 1 to 16; and The contact lens composition is brought into full contact with the lens surface of the contact lens.

18. The method for maintaining contact lenses according to claim 17, characterized in that: The contact lens is immersed in the composition for contact lens, and the contact lens is packed in a sealed packaging container together with the composition for contact lens.

19. The method for maintaining contact lenses according to claim 18, characterized in that: The water-soluble polymer cooperates with the beneficial ingredients in the contact lens composition to remain on the contact lens; wherein the water-soluble polymer interacts with the beneficial ingredients to increase the adsorption amount of the beneficial ingredients on the contact lens; wherein the beneficial ingredients are vitamins.

Images