Human transcranial ultrasound irradiation method, device, electronic equipment and storage medium

Abstract

The application provides a human transcranial ultrasound irradiation method, device, electronic equipment and storage medium. The target head sagittal plane tomographic image and the transverse plane tomographic image are acquired; a vertical coordinate system is established based on the sagittal plane tomographic image, and the target point coordinates of the insula in the vertical coordinate system are determined; based on the transverse plane tomographic image, the horizontal distance from the insula to the target head brain midline is measured; the world coordinate point of the insula is mapped in the world coordinate system according to the target point coordinates and the horizontal distance; and the ultrasound transducer is controlled to irradiate the real position of the insula, so that accurate targeted irradiation can be realized, the use cost of the low-intensity focused ultrasound technology is effectively reduced, and the operation is simpler.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of non-invasive transcranial neuromodulation, and in particular to a human transcranial ultrasound irradiation method, device, electronic equipment and storage medium. BACKGROUND

[0002] In recent years, low-intensity focused ultrasound has attracted widespread attention in the medical community as a cutting-edge neuromodulation method due to its significant advantages of non-invasiveness, high spatial resolution, and high penetration depth. Low-intensity focused ultrasound can precisely act on specific brain regions without damaging surrounding tissues, thereby achieving the regulation of neural activity.

[0003] Currently, the mainstream irradiation method mainly relies on high-precision neuro-navigation systems. These systems can track and locate the focal point of ultrasound in real time by combining imaging techniques such as magnetic resonance imaging (MRI) or computed tomography (CT), thereby achieving precise regulation of deep brain structures. However, high-precision neuro-navigation systems are not only expensive, but also mainly used in complex surgical procedures, which severely limits the application and development of low-intensity focused ultrasound technology in clinical practice.

[0004] In order to overcome this bottleneck, it is urgent to develop a feasible and cost-effective method to assist the application of low-intensity focused ultrasound in the brain. SUMMARY

[0005] In view of the above problems, a human transcranial ultrasound stimulation positioning method is proposed to overcome the above problems or at least partially solve the above problems, comprising:

[0006] A human transcranial ultrasound irradiation method, the method comprising:

[0007] Obtaining a target head sagittal section image and a transverse section image;

[0008] Establishing a vertical coordinate system based on the sagittal section image, and determining the target point coordinates of the insular lobe in the vertical coordinate system;

[0009] Based on the transverse section image, measuring the horizontal distance from the insular lobe to the target head midline;

[0010] According to the target point coordinates and the horizontal distance, mapping the world coordinate point of the insular lobe in the world coordinate system, the world coordinate point of the insular lobe being used to represent the real position of the insular lobe in three-dimensional space;

[0011] Controlling the ultrasound transducer to irradiate the real position of the insular lobe.

[0012] A human transcranial ultrasound irradiation method, the method comprising:

[0013] Obtaining a sagittal section image and a transverse section image of a target head;

[0014] Establishing a vertical coordinate system based on the sagittal section image, and determining a target point coordinate of the target control region in the vertical coordinate system;

[0015] Based on the transverse section image, measuring a horizontal distance from the target control region to a midline of the brain of the target head;

[0016] According to the target point coordinate and the horizontal distance, mapping a world coordinate point of the target control region in a world coordinate system, the world coordinate point of the target control region being used to represent a real position of the target control region in a three-dimensional space;

[0017] Controlling an ultrasonic transducer to irradiate the real position of the target control region;

[0018] The method further comprises:

[0019] Based on the sagittal section image, establishing a vertical coordinate system with a tip of a nose as an origin and a line connecting the tip of the nose and a front edge of a forehead as a vertical axis;

[0020] Constructing a contour of the target control region, taking a plurality of discrete points within the contour of the target control region, and calculating an average coordinate of the plurality of discrete points as the target point coordinate.

[0021] Preferably, the calculation formula of the average coordinate of the plurality of discrete points as the target point coordinate is:

[0022]

[0023] wherein (x i , y i ) is a coordinate of an i-th discrete point, and n is a total number of the discrete points.

[0024] Preferably, the target control region comprises an insular lobe.

[0025] Optionally, the method further comprises:

[0026] Based on the sagittal section image, establishing a vertical coordinate system with a tip of a nose as an origin and a line connecting the tip of the nose and a front edge of a forehead as a vertical axis;

[0027] Constructing a contour of the insular lobe, taking a plurality of discrete points within the contour of the insular lobe, and calculating an average coordinate of the plurality of discrete points as the target point coordinate.

[0028] Optionally, a plurality of discrete points are taken within the island lobe profile, and the average coordinates of the plurality of discrete points are calculated as the target point coordinates, and the calculation formula is:

[0029]

[0030] wherein (x i , y i ) is the coordinate of the i-th discrete point, and n is the total number of discrete points.

[0031] Optionally, according to the target point coordinates and the horizontal distance, the world coordinate point of the island lobe is mapped in the world coordinate system, including:

[0032] According to the preset conversion relationship, the abscissa in the target point coordinates is converted into the X-axis coordinate of the island lobe in the world coordinate system, the ordinate in the target point coordinates is converted into the Y-axis coordinate of the island lobe in the world coordinate system, and the horizontal distance is converted into the Z-axis coordinate of the island lobe in the world coordinate system.

[0033] Optionally, the ultrasonic transducer is controlled to irradiate the real position of the island lobe, including:

[0034] Adjusting the position of the ultrasonic transducer along the XOY plane direction of the world coordinate system, so that the focal point of the ultrasonic transducer and the world coordinate point of the island lobe are located on the same horizontal line, and controlling the irradiation direction of the ultrasonic transducer to be perpendicular to the XOY plane of the world coordinate system;

[0035] Adjusting the position of the ultrasonic transducer along the Z-axis direction, so that the focal point of the ultrasonic transducer and the world coordinate point of the island lobe are completely coincident;

[0036] Fixing and starting the ultrasonic transducer to irradiate the real position of the island lobe.

[0037] Optionally, before fixing and starting the ultrasonic transducer to irradiate the real position of the island lobe, it further includes:

[0038] Filling the bubble-free coupling agent between the scalp and the ultrasonic transducer.

[0039] Optionally, the way to obtain the target head sagittal section image and the cross-sectional image includes any one or more of the following: magnetic resonance imaging, computed tomography.

[0040] A human transcranial ultrasonic irradiation auxiliary positioning device, the device comprises:

[0041] An image acquisition module for acquiring a target head sagittal section image and a cross-sectional image;

[0042] A target point coordinate determination module for establishing a vertical coordinate system based on the sagittal section image and determining the target point coordinates of the island lobe in the vertical coordinate system;

[0043] a measurement module configured to measure a horizontal distance from the insula to a midline of the target head based on the cross-sectional tomographic image;

[0044] a mapping module configured to map a world coordinate point of the insula in a world coordinate system according to the target point coordinate and the horizontal distance, the world coordinate point of the insula being used to represent a real position of the insula in a three-dimensional space;

[0045] an ultrasonic transducer control module configured to control the ultrasonic transducer to irradiate the real position of the insula.

[0046] Optionally, the target point coordinate determination module comprises:

[0047] a target point coordinate calculation sub-module configured to establish a vertical coordinate system with a nose tip as an origin and a line connecting the nose tip and a frontal edge as a vertical axis based on the sagittal tomographic image, and to construct an insula contour, and to calculate an average coordinate of a plurality of discrete points in the insula contour as the target point coordinate.

[0048] An electronic device comprising a processor, a memory, and a computer program stored on the memory and capable of running on the processor, the computer program being executed by the processor to implement the steps of the transcranial ultrasound irradiation method of the human body as described above.

[0049] A computer readable storage medium having a computer program stored thereon, the computer program being executed by a processor to implement the steps of the transcranial ultrasound irradiation method of the human body as described above.

[0050] In the embodiment of the present application, the sagittal tomographic image and the cross-sectional tomographic image of the target head are obtained, a vertical coordinate system is established based on the sagittal tomographic image to determine the target point coordinate of the insula in the vertical coordinate system, a horizontal distance from the insula to the midline of the target head is measured based on the cross-sectional tomographic image, a world coordinate point of the insula is mapped in a world coordinate system according to the target point coordinate and the horizontal distance, and the ultrasonic transducer is controlled to irradiate the real position of the insula, so that accurate targeted irradiation can be achieved, the use cost of the low-intensity focused ultrasound technology is effectively reduced, and the operation is simpler. BRIEF DESCRIPTION OF DRAWINGS

[0051] In order to more clearly illustrate the technical solutions of the present application, the following will briefly introduce the drawings needed to be used in the description of the present application. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0052] Figure 1 is a step flow chart of a transcranial ultrasound irradiation method of the human body provided by an embodiment of the present application;

[0053] Figure 2 is an example of a transverse plane and a sagittal plane image of a head of a subject for a head MRI examination according to an embodiment of the present application;

[0054] Figure 3 is a schematic diagram of a coordinate axis for establishing a target sagittal plane image of a head of a subject according to an embodiment of the present application;

[0055] Figure 4 is a schematic diagram of measuring insular coordinates according to a transverse plane image and a sagittal plane image of a head according to an embodiment of the present application;

[0056] Figure 5 is a schematic diagram of measuring a horizontal distance from an insula to a target midline of a head of a subject according to a transverse plane image of a head according to an embodiment of the present application;

[0057] Figure 6 is a schematic diagram of a human transcranial ultrasound irradiation auxiliary positioning device according to an embodiment of the present application;

[0058] Figure 7 is a schematic diagram of a human head placement position according to an embodiment of the present application; Figure 6

[0059] Figure 8 Figure 9 is a schematic diagram of an ultrasound transducer cooperating with a head according to an embodiment of the present application. Figure 6 DETAILED DESCRIPTION

[0060] In order to make the above objectives, characteristics and advantages of the present application more apparent, more comprehensible, the present application will be further described in detail below with reference to the accompanying drawings and specific embodiments. Obviously, the described embodiments are some embodiments of the present application, but not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0061] Referring to Figures 1 to 9 , a schematic diagram of a step flow of a human transcranial ultrasound irradiation method suitable for focused ultrasound according to an embodiment of the present application is shown, which can specifically include the following steps:

[0062] Step 101, obtaining a target sagittal plane image and a transverse plane image of a head;

[0063] In some embodiments of the present application, the manner of obtaining the target sagittal plane image and the transverse plane image of the head includes any one or more of the following: magnetic resonance imaging (MRI), computed tomography (CT).

[0064] ​​​Magnetic Resonance Imaging (MRI) is a non-invasive medical imaging technique that uses strong magnetic fields and radio waves to generate detailed images of internal structures of the human body. In practical applications, MRI can provide high-resolution images of soft tissues, which helps doctors make accurate diagnoses.

[0065] Referring to Figures 2 to 5 In some embodiments of the present application, the target head can be scanned using magnetic resonance imaging technology to obtain sagittal section images and transverse section images of the target head, which can provide high-resolution images of soft tissues, thereby improving the accuracy of subsequent calculation of the real position of the insular lobe and further improving the accuracy of target irradiation. Those skilled in the art can also select computer tomography (CT) or other medical imaging techniques to obtain sagittal section images and transverse section images of the target head according to actual conditions, and the present application does not limit this.

[0066] In practical applications, MRI images are easily affected by various noises, such as random noise and artifacts, and therefore, the present application can also select to use a pre-trained deep learning model (such as a convolutional neural network) to realize denoising of the MRI images. It can be understood that the pre-trained deep learning model can automatically learn complex denoising patterns, realize rapid processing of MRI images with different situations, and effectively improve the efficiency of obtaining sagittal section images and transverse section images of the target head.

[0067] Step 102, establishing a vertical coordinate system based on the sagittal section image, and determining the target point coordinates of the insular lobe (the insular lobe is specifically selected as the target control region in this embodiment, and in other embodiments, the target control region can also be a transcranial brain region, such as the prefrontal cortex, the thalamus, the temporal lobe, and deep brain tissue) in the vertical coordinate system;

[0068] In some embodiments of the present application, as shown in Figure 3 , Figure 4 The vertical coordinate system can be established based on the sagittal section image, with the tip of the nose as the origin and the line connecting the tip of the nose and the front edge of the forehead as the vertical axis; wherein the target point coordinates of the insular lobe in the vertical coordinate system can be obtained by the following method:

[0069] Constructing the outline of the insular lobe, taking a plurality of discrete points within the outline of the insular lobe, and calculating the average coordinates of the plurality of discrete points as the target point coordinates.

[0070] Specifically, the two-dimensional coordinates of a plurality of discrete points can be measured directly using a scale or coordinate paper to obtain the two-dimensional coordinates of a plurality of discrete points; then the average value of the obtained two-dimensional coordinates of a plurality of discrete points is calculated using the following formula, and is recorded as the target point coordinates:

[0071]

[0072] wherein (x i , y i ) is the coordinate of the i-th discrete point, and n is the total number of discrete points.

[0073] Suppose that only three discrete points are taken in this embodiment (only exemplary, in actual application, the more discrete points, the higher the accuracy of the target point coordinates), the first discrete point coordinate can be taken as (10, 20), the second discrete point coordinate can be taken as (12, 10), and the third discrete point coordinate can be taken as (14, 24), and the coordinates of the above three discrete points are brought into the calculation formula as above, so that the coordinate of the target point M is (12, 18).

[0074] In some embodiments of the present application, since the shape of the human insula is similar to a triangle, the triangle can be used as the contour of the insula, and then the perpendicular bisectors of the three sides of the triangle are drawn, and the intersection point is taken as the target point, and the scale or coordinate paper is used to directly measure the target point coordinates. The person skilled in the art can select the determination method of the target point coordinates according to the actual situation, and the present application does not limit this.

[0075] Step 103, measuring the horizontal distance from the insula to the target head brain midline based on the cross-sectional tomographic image;

[0076] In some embodiments of the present application, as shown in Figure 5 Since the human brain is structurally symmetrical left and right, after obtaining the cross-sectional tomographic image of the target head, the brain midline can be drawn, and then the position of the insula is determined in the cross-sectional tomographic image, and the horizontal distance from the insula to the brain midline is directly measured by using the scale.

[0077] Step 104, mapping the world coordinate point of the insula in the world coordinate system according to the target point coordinates and the horizontal distance, wherein the world coordinate point of the insula is used to represent the real position of the insula in the three-dimensional space;

[0078] Specifically, the horizontal coordinate in the target point coordinates can be converted into the X-axis coordinate of the insula in the world coordinate system, the vertical coordinate in the target point coordinates can be converted into the Y-axis coordinate of the insula in the world coordinate system, and the horizontal distance can be converted into the Z-axis coordinate of the insula in the world coordinate system according to the preset conversion relationship.

[0079] In actual application, the sagittal tomographic image and the cross-sectional tomographic image of the target head can be attached with a scale, and the scale is used to represent the relationship between the distance on the image and the distance in the real world.

[0080] Exemplarily, when the scale of the target head sagittal section tomographic image and the transverse section tomographic image is 1:2, the target point coordinate is (12, 18), and the horizontal distance is 16, the three-dimensional coordinate of the insular lobe in the world coordinate system can be calculated as (24, 36, 32), thereby realizing mapping of the world coordinate point of the insular lobe in the world coordinate system.

[0081] Step 105, controlling the ultrasonic transducer to irradiate the real position of the insular lobe;

[0082] In some embodiments of the present application, irradiation of the real position of the insular lobe can be realized by the following way:

[0083] Sub-step 1051, adjusting the position of the ultrasonic transducer along the XOY plane direction of the world coordinate system so that the focal point of the ultrasonic transducer is located on the same horizontal line as the world coordinate point of the insular lobe, and controlling the irradiation direction of the ultrasonic transducer to be perpendicular to the XOY plane of the world coordinate system;

[0084] It can be understood that, in some embodiments of the present application, adjusting the position of the ultrasonic transducer along the XOY plane direction of the world coordinate system so that the focal point of the ultrasonic transducer is located on the same horizontal line as the world coordinate point of the insular lobe, and controlling the irradiation direction of the ultrasonic transducer to be perpendicular to the XOY plane of the world coordinate system, can preliminarily determine the horizontal position of the ultrasonic transducer, that is, the ultrasonic transducer at this time can irradiate along the horizontal direction of the real position of the insular lobe, but the focal point of the ultrasonic transducer does not completely coincide with the world coordinate point of the insular lobe, that is, the ultrasonic transducer at this time cannot realize accurate irradiation of the insular lobe.

[0085] Sub-step 1052, adjusting the position of the ultrasonic transducer along the Z-axis direction so that the focal point of the ultrasonic transducer completely coincides with the world coordinate point of the insular lobe;

[0086] Based on the above problem, the horizontal position of the ultrasonic transducer needs to be adjusted along the Z-axis direction of the world coordinate system until the focal point of the ultrasonic transducer completely coincides with the world coordinate point of the insular lobe.

[0087] Sub-step 1053, fixing and starting the ultrasonic transducer to irradiate the real position of the insular lobe.

[0088] In the embodiments of the present application, the ultrasonic transducer can be close to the scalp of the temporal lobe of the subject and maintain horizontal irradiation, that is, ensure that the irradiation direction of the ultrasonic transducer is perpendicular to the sagittal plane of the head of the subject, which can avoid the complex problem of angle adjustment of selecting other head acoustic windows.

[0089] In addition, it can be understood that the insula is an organ with a certain volume but a small volume, and when the disease occurs, a specific part of the insula may be diseased, and the embodiment of the application abstracts the insula as a point, which is beneficial to more accurately target the diseased part for targeted irradiation.

[0090] The embodiment of the application provides a human cranial ultrasound irradiation method and device, electronic equipment and storage medium. By acquiring a target head sagittal section image and a transverse section image; based on the sagittal section image, a vertical coordinate system is established, and the target point coordinates of the insula in the vertical coordinate system are determined; based on the transverse section image, the horizontal distance from the insula to the target head brain midline is measured; according to the target point coordinates and the horizontal distance, the world coordinate point of the insula is mapped in the world coordinate system; and the ultrasound transducer is controlled to irradiate the real position of the insula, which can realize accurate targeted irradiation and effectively reduce the use cost of low-intensity focused ultrasound technology, and the operation is simpler.

[0091] As shown in Figures 6 to 9 , as another human cranial ultrasound irradiation method of the application, it can also be realized by the following steps:

[0092] Step 201, three mutually perpendicular fixed plates with scales are set, wherein the bottom fixed plate has a trapezoidal opening, and the left fixed plate has a circular opening; a space coordinate system is established with the lower right corner of the front fixed plate as the origin, the side as the Y axis and the bottom as the Z axis, as shown in Figure 6 .

[0093] Step 202, the head posture of the subject is fixed, so that the subject's nose tip is placed in front of the trapezoidal opening, and the forehead is attached to the front fixed plate, as shown in Figure 6 , wherein the trapezoidal opening is set to ensure normal breathing of the subject.

[0094] Step 203, repeat steps 101 to 105 to determine and fix the position of the ultrasound transducer, and record the position of the subject's nose tip at this time.

[0095] Step 204, replace different subjects so that their nose tips are placed at the pre-recorded nose tip position, and the forehead is attached to the front fixed plate, and the ultrasound transducer is started to irradiate the insula of the subject.

[0096] It needs to be understood that in actual application, because the scaling ratio or scale of each target head sagittal plane tomographic image and cross-sectional tomographic image is consistent, and the head structure of each subject is basically the same, the world coordinates of the insular lobe position of each subject are also consistent after being mapped to the world coordinate system. Therefore, in the embodiment of the present application, different subjects only need to place the nose tip at the pre-recorded nose tip position and ensure that the forehead is attached to the front side fixing plate to ensure that the body odor of the subject is not inclined, so that the actual target region of the head and the calculated target position coincide, and the ultrasonic transducer can be started to irradiate the insular lobe, greatly improving the irradiation efficiency, without repeatedly mapping the world coordinates of the insular lobe of the subject and repeatedly adjusting the position of the ultrasonic transducer.

[0097] In addition, before the real position of the insular lobe is irradiated after the ultrasonic transducer is fixed and started, a bubble-free coupling agent can be filled between the scalp of the subject and the ultrasonic transducer to ensure the transmission of acoustic energy and reduce the attenuation of acoustic energy.

[0098] The principle of the transcranial ultrasonic irradiation method of the human body in the embodiment of the present application is based on projection irradiation of the head sagittal plane, and the acoustic window is selected in the temporal lobe region. The positioning accuracy for deep brain tissues such as the temporal lobe, insular lobe and hippocampus is high, and the use is relatively limited for the frontal lobe and the superficial layer of the parietal lobe. In the use process, the absorption and interference of the skull on acoustic energy can be evaluated, and an appropriate focal length can be set to ensure the safest and most effective stimulation of focused ultrasound.

[0099] The above embodiment of the present application provides a low-cost and simple brain target tissue positioning method, which can solve the targeting problem. This method can be used not only for ultrasonic regulation, but also for other non-invasive regulation methods. The principle is to project the intracranial target organ on the scalp in the head sagittal plane, and then measure the vertical distance from the scalp to the target organ by means of the head MRI image. In this way, targeted stimulation can be achieved by adjusting the position of the focused ultrasound focal point, which is low in cost and convenient to operate.

[0100] It needs to be explained that for the method embodiment, in order to simply describe, it is expressed as a series of action combinations, but those skilled in the art should know that the embodiment of the present application is not limited by the described action sequence, because according to the embodiment of the present application, certain steps can be adopted in other order or simultaneously. Secondly, those skilled in the art should know that the embodiments described in the specification all belong to preferred embodiments, and the involved actions are not necessarily required by the embodiment of the present application.

[0101] An embodiment of the present application provides a module schematic diagram of a human transcranial ultrasonic irradiation auxiliary positioning device, which can specifically include the following modules:

[0102] An image acquisition module is configured to acquire a sagittal tomographic image and a transverse tomographic image of a target head;

[0103] A target point coordinate determination module is configured to establish a vertical coordinate system based on the sagittal tomographic image, and determine a target point coordinate of the insula in the vertical coordinate system;

[0104] A measurement module is configured to measure a horizontal distance from the insula to a target head brain midline based on the transverse tomographic image;

[0105] A mapping module is configured to map a world coordinate point of the insula in a world coordinate system according to the target point coordinate and the horizontal distance, the world coordinate point of the insula being used to represent a real position of the insula in a three-dimensional space;

[0106] An ultrasonic transducer control module is configured to control the ultrasonic transducer to irradiate the real position of the insula.

[0107] Optionally, the target point coordinate determination module comprises:

[0108] A target point coordinate calculation submodule is configured to establish a vertical coordinate system with a nose tip as an origin and a line connecting the nose tip and a forehead front edge as a vertical axis based on the sagittal tomographic image, construct an insula contour, take a plurality of discrete points in the insula contour, and calculate an average coordinate of the plurality of discrete points as the target point coordinate.

[0109] Optionally, a calculation formula of the average coordinate of the plurality of discrete points as the target point coordinate is as follows:

[0110]

[0111] wherein, (x i , y i ) is a coordinate of an i-th discrete point, and n is a total number of the discrete points.

[0112] Optionally, the mapping module comprises:

[0113] A coordinate conversion submodule is configured to convert a horizontal coordinate in the target point coordinate into an X-axis coordinate of the insula in the world coordinate system, convert a vertical coordinate in the target point coordinate into a Y-axis coordinate of the insula in the world coordinate system, and convert the horizontal distance into a Z-axis coordinate of the insula in the world coordinate system according to a preset conversion relationship.

[0114] Optionally, the ultrasonic transducer control module comprises:

[0115] The ultrasonic transducer adjusting sub-module is used for adjusting the position of the ultrasonic transducer along the XOY plane direction of the world coordinate system, so that the focal point of the ultrasonic transducer is located on the same horizontal line as the world coordinate point of the insular lobe, and the irradiation direction of the ultrasonic transducer is perpendicular to the XOY plane of the world coordinate system; the position of the ultrasonic transducer is adjusted along the Z axis direction, so that the focal point of the ultrasonic transducer is completely coincident with the world coordinate point of the insular lobe; the ultrasonic transducer is fixed and started, and the real position of the insular lobe is irradiated.

[0116] Optionally, the method further comprises:

[0117] The coupling agent filling module is used for filling the bubble-free coupling agent between the scalp and the ultrasonic transducer.

[0118] Optionally, the target head sagittal section image and the target head transverse section image are acquired by any one or more of the following: magnetic resonance imaging, computed tomography.

[0119] An embodiment of the present application further provides an electronic device, which can comprise a processor, a memory, and a computer program stored on the memory and capable of running on the processor, and the computer program is executed by the processor to realize the transcranial ultrasonic irradiation method of the human body.

[0120] An embodiment of the present application further provides a computer readable storage medium, and the computer readable storage medium stores a computer program, and the computer program is executed by a processor to realize the transcranial ultrasonic irradiation method of the human body.

[0121] For the device embodiment, since it is basically similar to the method embodiment, the description is relatively simple, and the related parts are referred to the part of the method embodiment.

[0122] Each embodiment in the specification is described in a progressive manner, and each embodiment mainly describes the difference from other embodiments, and the same and similar parts of each embodiment are referred to each other.

[0123] Those skilled in the art should understand that the embodiments of the present application can be provided as a method, a device, or a computer program product. Therefore, the embodiments of the present application can adopt a complete hardware embodiment, a complete software embodiment, or an embodiment combining software and hardware aspects. Moreover, the embodiments of the present application can adopt the form of a computer program product implemented on one or more computer usable storage media (including but not limited to disk storage, CD-ROM, optical storage, etc.) containing computer usable program codes.

[0124] The above provides a kind of human transcranial ultrasound irradiation method, device, electronic equipment and storage medium, are introduced in detail, the principle and implementation mode of the present application are described in this paper by applying specific examples, the above example is only used to help understand the method of the present application and its core idea;At the same time, for those skilled in the art, according to the idea of the present application, there will be changes in specific implementation mode and application range, and the above description should not be understood as limiting the present application.

Claims

1. A method of human transcranial ultrasound irradiation, characterized in that, The method comprises: acquiring a target head sagittal plane tomographic image and a target head transverse plane tomographic image; establishing a vertical coordinate system based on the sagittal plane tomographic image, and determining target point coordinates of a target regulation region on the vertical coordinate system; the target regulation region comprises an insular lobe, a triangle is first taken as an outline of the insular lobe, then vertical bisectors of three sides of the triangle are drawn, and an intersection point thereof is taken as a target point, and a target point coordinate is directly measured by using a scale or a coordinate paper; based on the transverse plane tomographic image, a horizontal distance from the target regulation region to a target head midline is measured; according to the target point coordinates and the horizontal distance, world coordinate points of the target regulation region are mapped in a world coordinate system, and the world coordinate points of the target regulation region are used to represent a real position of the target regulation region in a three-dimensional space; controlling an ultrasonic transducer to irradiate the real position of the target regulation region; wherein, the establishing of the vertical coordinate system based on the sagittal plane tomographic image and the determination of the target point coordinates of the target regulation region on the vertical coordinate system comprise: based on the sagittal plane tomographic image, a vertical coordinate system is established with a nose tip as an origin and a connecting line of the nose tip and a forehead front edge as a vertical shaft; a contour of the target regulation region is constructed, a plurality of discrete points are taken in the contour of the target regulation region, and average coordinates of the plurality of discrete points are calculated as target point coordinates; the method further comprises: setting three mutually perpendicular fixed plates with scales, wherein a bottom fixed plate has a trapezoidal opening, and a left fixed plate has a circular opening; a space coordinate system is established with a lower right corner of a front fixed plate as an origin, a side as a Y axis, and a bottom as a Z axis; fixing a head posture of a subject, so that a nose tip of the subject is placed in front of the trapezoidal opening, and a forehead of the subject is attached to the front fixed plate; determining and fixing a position of an ultrasonic transducer, recording a position of the nose tip of the subject at this time, and starting the ultrasonic transducer to irradiate an insular lobe of the subject.

2. The method of claim 1, wherein, a calculation formula of the average coordinates of the plurality of discrete points as the target point coordinates is: ； where (x i , y i ) is the coordinate of the i-th discrete point, and n is the total number of discrete points.

3. The method of claim 2, wherein, the mapping of the world coordinate points of the insular lobe in the world coordinate system according to the target point coordinates and the horizontal distance comprises: according to a preset conversion relationship, converting a horizontal coordinate in the target point coordinates into an X axis coordinate of the insular lobe in the world coordinate system, converting a vertical coordinate in the target point coordinates into a Y axis coordinate of the insular lobe in the world coordinate system, and converting the horizontal distance into a Z axis coordinate of the insular lobe in the world coordinate system.

4. The method of claim 3, wherein, the irradiation of the real position of the insular lobe by the ultrasonic transducer comprises: adjusting the position of the ultrasonic transducer along an XOY plane direction of the world coordinate system, so that a focal point of the ultrasonic transducer and the world coordinate point of the insular lobe are located on a same horizontal line, and an irradiation direction of the ultrasonic transducer is perpendicular to the XOY plane of the world coordinate system; adjusting the position of the ultrasonic transducer along a Z axis direction, so that the focal point of the ultrasonic transducer and the world coordinate point of the insular lobe are completely coincident; fixing and starting the ultrasonic transducer to irradiate the real position of the insular lobe.

5. The method of claim 4, wherein, Before the real position of the insular lobe is irradiated by the fixed and started ultrasonic transducer, further comprising: Filling a bubble-free coupling agent between the scalp and the ultrasonic transducer.

6. The method of claim 5, wherein, The method for obtaining the sagittal section image and the cross section image of the target head comprises any one or more of the following: magnetic resonance imaging, computed tomography.

7. A device for assisting positioning of transcranial ultrasound irradiation of a human body, characterized in that The device comprises: An image acquisition module for acquiring a sagittal section image and a cross section image of a target head; A target point coordinate determination module for establishing a vertical coordinate system based on the sagittal section image, determining the target point coordinates of the insular lobe in the vertical coordinate system, taking a triangle as the outline of the insular lobe, then drawing vertical bisectors of the three sides of the triangle respectively, taking the intersection point as the target point, and directly measuring the target point coordinates by using a scale or coordinate paper; A measurement module for measuring the horizontal distance from the insular lobe to the midline of the brain of the target head based on the cross section image; A mapping module for mapping the world coordinate point of the insular lobe in the world coordinate system according to the target point coordinates and the horizontal distance, the world coordinate point of the insular lobe being used to represent the real position of the insular lobe in the three-dimensional space; An ultrasonic transducer control module for controlling the ultrasonic transducer to irradiate the real position of the insular lobe; The target point coordinate determination module comprises: A target point coordinate calculation submodule for establishing a vertical coordinate system with the tip of the nose as the origin and the line connecting the tip of the nose and the front edge of the forehead as the vertical axis based on the sagittal section image, and for constructing the outline of the insular lobe, taking a plurality of discrete points within the outline of the insular lobe, and calculating the average coordinates of the plurality of discrete points as the target point coordinates; The human transcranial ultrasonic irradiation auxiliary positioning device further comprises: Three mutually perpendicular fixed plates with scales are provided, wherein the bottom fixed plate has a trapezoidal opening, and the left fixed plate has a circular opening; a space coordinate system is established with the lower right corner of the front fixed plate as the origin, the side as the Y axis, and the bottom as the Z axis; The head posture of the subject is fixed so that the tip of the nose of the subject is in front of the trapezoidal opening, and the forehead is attached to the front fixed plate; The position of the ultrasonic transducer is determined and fixed, the position of the tip of the nose of the subject at this time is recorded, and the ultrasonic transducer is started to irradiate the insular lobe of the subject.

8. An electronic device, comprising: A processor, a memory, and a computer program stored on the memory and capable of running on the processor, wherein the computer program is executed by the processor to implement the steps of the human transcranial ultrasonic irradiation method according to any one of claims 1 to 6.

9. A computer-readable storage medium, characterized in that, A computer program is stored on the computer readable storage medium, and the computer program is executed by the processor to implement the steps of the human transcranial ultrasonic irradiation method according to any one of claims 1 to 6.

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