Preparation method of classic famous formula ephedra decoction

Abstract

The invention discloses a classic famous formula ephedra decoction and a preparation method thereof, the ephedra decoction is derived from the theory of typhoid, is aboriginal by famous doctors in East Han, is a prescription created by Zhang gutta-percha and used for treating solar typhoid exterior syndromes, and the medicine is prepared from 9g of ephedra, 6g of cassia twig, 3g of liquorice and 6g of scalded bitter apricot kernels. The medicine has the effects of inducing sweat, dispelling exogenous evils, freeing lung and relieving asthma, and is good in treatment effect, lasting in effect and free of toxic and side effects; and the ephedra decoction is prepared into granules by using a modern preparation technology, so that the compliance of a patient to the medicine is improved, the production process is simple, and the production cost is low.

Description

Technical Field

[0001] The present invention relates to the pharmaceutical field, and more particularly to a classic prescription medicine with the effects of diaphoresis, relieving exterior symptoms, promoting lung function and relieving asthma, and a preparation method thereof. Background Art

[0002] In April 2018, the state released the "Catalogue of Ancient Classic Prescriptions (First Batch)", which included Mahuang Tang. Written by Zhang Zhongjing during the Han Dynasty, Mahuang Tang is a classic prescription for diaphoresis, dispelling exterior pathogens, and relieving asthma. It primarily treats wind-cold syndromes characterized by aversion to cold and fever, headache and body aches, wheezing without sweating, a thin white tongue coating, and a floating, tight pulse. It is commonly used to treat colds, acute bronchitis, and bronchial asthma. The main ingredient, ephedra, induces diaphoresis, dispelling exterior pathogens, dispelling lung pathogens, and relieving asthma; the auxiliary ingredient, cinnamon twig, warms the meridians and dispels cold; the adjuvant, apricot kernel, descends and benefits lung qi; and the guiding ingredient, licorice, regulates the dispersing and descending effects of ephedra and apricot kernel, mitigating the harsh effects of the combined effects of ephedra and cinnamon, preventing excessive perspiration that could damage vital energy. By developing the classic prescription Mahuang Tang into a granule formulation using traditional preparation methods, combined with modern usage and clinical practice, this approach will improve patient compliance and facilitate the integration of traditional Chinese medicine with modern technology to better serve the public. Summary of the Invention

[0003] The purpose of the present invention is to provide a classic prescription medicine with the effects of diaphoresis, relieving exterior symptoms, promoting lung function and relieving asthma; Another object of the present invention is to provide a method for preparing the classic medicine.

[0004] The object of the present invention is achieved in the following ways: A classic prescription medicine with the effects of diaphoresis, relieving exterior symptoms, promoting lung function and relieving asthma, characterized in that the medicine is composed of four herbs: ephedra, cinnamon twig, liquorice and bitter almond, wherein the ephedra is 9 parts by weight, the cinnamon twig is 6 parts by weight, the liquorice is 3 parts by weight and the boiled bitter almond is 6 parts by weight.

[0005] The above-mentioned classic prescription medicine with the effects of diaphoresis, relieving exterior symptoms, promoting lung function and relieving asthma is preferably composed of 41.4g of ephedra, 27.6g of cinnamon twig, 13.8g of liquorice and 26g of boiled bitter almond.

[0006] The ephedra used in this invention has the effects of inducing sweating and dispelling cold, promoting lung function and relieving asthma, and promoting diuresis and reducing swelling; cinnamon twig is pungent and warm, dispelling wind and cold, and can treat colds, fever, and chills; licorice root clears heat and detoxifies, moistens the lungs and relieves coughs, and harmonizes the properties of the various herbs; bitter almonds lower qi, relieve coughs and relieve asthma, and moisten the intestines and promote bowel movements. It is used for cough and asthma, chest fullness and excessive phlegm, and constipation caused by dry intestines. The four herbs complement each other, and Mahuang Decoction has the effects of inducing sweating and dispelling cold, promoting lung function and relieving asthma. It is mainly used to treat symptoms of wind-cold caused by exogenous wind, including aversion to cold and fever, asthma without sweating, headache and cold body, thin white tongue coating, and floating and tight pulse.

[0007] The above-mentioned classic prescription medicine with the effects of sweating, relieving exterior symptoms, promoting lung function and relieving asthma is prepared into a preparation with pharmaceutically acceptable excipients.

[0008] The above-mentioned classic prescription medicine with the effects of diaphoresis, relieving exterior symptoms, promoting lung function and relieving asthma is made into granules.

[0009] The preparation method of the above-mentioned classic prescription medicine with the effects of diaphoresis, relieving exterior symptoms, promoting lung function and relieving asthma comprises the following steps: (1) According to the prescription ratio of Mahuang Decoction, weigh 41.4g of ephedra, 27.6g of cinnamon twig, 13.8g of roasted licorice root, and 26.0g of boiled bitter almond; (2) First, add ephedra to a stainless steel pot, add 10-16 times the amount of purified water for the first time, bring to a boil, add other prescribed medicinal materials, decoct for 60-90 minutes, filter through 200 mesh, and obtain the residue and decoction; (3) Add 8-10 times the amount of purified water for the second time, boil for 30-60 minutes, and filter through 200 mesh to obtain the residue and decoction; (4) Combine the two decoctions, measure the volume, and continue to concentrate 1.17-1.19 to obtain an extract; (5) Dry, add auxiliary materials such as dextrin and stevioside, and granulate.

[0010] The preparation method of the above-mentioned classic prescription medicine with the effects of sweating, relieving exterior symptoms, promoting lung function and relieving asthma, preferably in steps (2) and (3), the first addition of water is 10 times the amount, and the decoction time is 1.5 hours; the second addition of water is 8 times the amount, and the decoction time is 1 hour. The concentration conditions are: the decoctions filtered twice are combined and then heated and concentrated at a concentration temperature of 70°C, and concentrated to 1.17-1.19 to form an extract; the drying and granulation conditions are: the drying method is spray drying, and the drying temperature is 60°C. Specific implementation method: The present invention is further described below through specific test examples.

[0012] The classic prescription medicine with the effects of diaphoresis, relieving exterior symptoms, promoting lung function and relieving asthma produced in this embodiment is composed of ephedra, cassia twig, liquorice and stewed bitter almonds.

[0013] The preparation method of the drug is carried out according to the following steps: (1) According to the prescription ratio of Mahuang Decoction, weigh 41.4g of ephedra, 27.6g of cinnamon twig, 13.8g of roasted licorice root, and 26.0g of boiled bitter almond; (2) First, add ephedra to a stainless steel pot, add 10 times the amount of purified water for the first time, bring to a boil, add other prescribed medicinal materials, decoct for 90 minutes, filter through 200 mesh, and obtain the residue and decoction; (3) Add 8 times the amount of purified water for the second time, boil for 60 minutes, and filter through 200 mesh to obtain the residue and decoction; (4) Combine the two decoctions, measure the volume, and continue to concentrate 1.17-1.19 to obtain an extract; (5) Dry, add auxiliary materials dextrin 10-15% and stevioside 0.04-0.06%, and granulate.

Claims

1. A classic prescription medicine with the functions of diaphoresis, relieving exterior symptoms, promoting lung function and relieving asthma, characterized in that: The classic prescription is composed of ephedra, cassia twig, liquorice and bitter almond, wherein ephedra is 9 parts by weight, cassia twig is 6 parts by weight, liquorice is 3 parts by weight and stewed bitter almond is 6 parts by weight.

2. The classic prescription of Mahuang Decoction with the effects of diaphoresis, relieving exterior symptoms, and tonifying the lungs and relieving asthma according to claim 1, characterized in that: The medicine is composed of ephedra, cassia twig, liquorice and bitter almond, wherein ephedra accounts for 9 parts by weight, cassia twig accounts for 6 parts by weight, liquorice accounts for 3 parts by weight and boiled bitter almond accounts for 6 parts by weight.

3. The classic prescription Mahuang Decoction with the effects of diaphoresis, relieving exterior symptoms, and promoting lung function and relieving asthma according to claim 1 or 2, characterized in that The preparation method is prepared by the following method: According to the prescription, weigh 41.4g of ephedra, 27.6g of cinnamon twig, 13.8g of liquorice and 26.0g of boiled bitter almond. First, add ephedra to a stainless steel pot, add 10-16 times the amount of purified water for the first time, boil, add other prescribed medicinal materials, decoct for 60-90min, filter, and obtain medicinal residue and decoction; for the second time, continue to add 8-10 times the amount of purified water to the medicinal residue, decoct for 30-60min, filter, and obtain medicinal residue and decoction; combine the two decoctions, measure the volume, continue to concentrate to an extract, concentrate to 1.17-1.19, dry, add auxiliary materials, crush and granulate.

4. The medicine having the effects of diaphoresis, relieving exterior symptoms, and promoting lung function and relieving asthma according to claim 1 or 2, characterized in that The excipients of this drug are dextrin and steviol glycoside.

5. The medicine with the effects of diaphoresis, relieving exterior symptoms, and promoting lung function and relieving asthma according to claim 3, characterized in that The dosage form of this medicine is granules.

6. A method for preparing the pharmaceutical composition having the effects of relieving cough, eliminating phlegm and relieving asthma according to claim 1 or 2, characterized in that The method comprises the following steps: (1) According to the prescription ratio of Ma Huang Tang, weigh 41.4 g of ephedra, 27.6 g of cinnamon twig, 13.8 g of roasted licorice root, and 26.0 g of stewed bitter almond; (2) First, add ephedra to a stainless steel pot, add 10-16 times the amount of purified water for the first time, bring to a boil, add other prescribed medicinal materials, boil for 60-90 minutes, filter through 200 mesh, and obtain the residue and decoction; (3) Add 8-10 times the amount of purified water for the second time, boil for 30-60 min, filter through 200 mesh to obtain the residue and decoction; (4) Combine the two decoctions, measure the volume, and continue to concentrate 1.17-1.19 to an extract; (5) Drying, adding auxiliary materials such as dextrin and stevioside, and granulating.

7. The method for preparing a drug having the effects of diaphoresis, relieving exterior symptoms, and clearing the lungs and relieving asthma according to claim 6, characterized in that The optimal extraction process described in steps (2) and (3) is to add 10 times the amount of water for the first time and boil for 1.5 hours; and to add 8 times the amount of water for the second time and boil for 1 hour.

8. The method for preparing the medicine having the effects of diaphoresis, relieving exterior symptoms, and clearing the lungs and relieving asthma according to claim 6, characterized in that The concentration condition in step (4) is a concentration temperature of 70° C., and a concentration method of heating concentration. The filtrate is heated at 70° C. and concentrated to a water extract with a relative density of 1.17-1.

19.

9. The method for preparing a drug having the effects of diaphoresis, relieving exterior symptoms, and clearing the lungs and relieving asthma according to claim 6, characterized in that The auxiliary material ratio in step (5) is 10-15% dextrin and 0.04-0.06% stevioside.

10. The method for preparing a drug having the effects of diaphoresis, relieving exterior symptoms, and clearing the lungs and relieving asthma according to claim 6, characterized in that The drying method is spray drying, and the drying temperature is 60°C.