Antibacterial composition

Abstract

The invention discloses an antibacterial composition which comprises 5-8 wt% of sodium lauroyl sarcosinate, 5-8 wt% of cocamidopropyl betaine and 2-4 wt% of sodium laureth sulfate, the pH value is 4-5.5, through reasonable combination and compatibility of different surfactants, the antibacterial composition has an obvious antibacterial synergistic effect, the antibacterial rates of candida albicans, staphylococcus aureus and escherichia coli are all larger than 90%, and the antibacterial effect is good. The compound can be used for preparing various washing and nursing materials such as laundry detergents, hand sanitizers, bath foam and private part care solutions.

Description

Technical Field

[0001] The invention belongs to the technical field of preparation of antibacterial agents for washing and skin care, and relates to a chemical composition with broad-spectrum antibacterial effect based on multiple surface active ingredients. Background Art

[0002] Currently, the prevalence of antibiotic-resistant microorganisms is increasing, especially during the change of seasons, and the incidence of infections such as Escherichia coli, Staphylococcus aureus, and Candida albicans has increased significantly.

[0003] Antibacterial agents refer to substances that can prevent the growth and reproduction of microorganisms within a certain period of time. Cleansing products with antibacterial and antimicrobial effects are becoming more and more popular in the market.

[0004] Most of the existing antibacterial and antibacterial cleaning products are added with chemical antibacterial agents such as potassium permanganate, boric acid, hydrogen peroxide, iodine or alcohol, or antibacterial / antibacterial ingredients such as triclosan, parachloroxylenol, chlorhexidine disal, etc., which are highly irritating to the skin and mucous membranes, and can easily cause damage to the skin or lead to rough skin.

[0005] Natural antibacterial agents with natural ingredients as the main body have good antibacterial effects, but because natural antibacterial agents often have a "fence effect", that is, they have a strong inhibitory effect on certain types of microorganisms, but the effect on other types of microorganisms is not obvious. Therefore, the application of single natural ingredient antibacterial agents has certain limitations. In addition, the plant-derived ingredients in natural antibacterial active ingredients generally contain a variety of effective ingredients, such as polysaccharides, flavonoids, alkaloids, terpenes, etc., which are easy to deteriorate under normal storage conditions.

[0006] Surfactants are organic compounds composed of hydrophilic polar groups and hydrophobic nonpolar groups. This structural feature determines many of its special properties. Surfactants can be divided into four categories: anionic surfactants, cationic surfactants, zwitterionic surfactants and nonionic surfactants, depending on whether the surfactant can dissociate in aqueous solution and the type of charge it carries after dissociation. Among them, anionic surfactants have good cleaning, foaming, dispersing, emulsifying, wetting and other properties. They are widely used as detergents, foaming agents, wetting agents, emulsifiers and dispersants. Not only does it account for the first place in surfactant production, but it is also the main ingredient in toiletries.

[0007] As we all know, most surfactants with antibacterial effects are cationic surfactants, such as quaternary ammonium antibacterial agent benzalkonium bromide, biguanide antibacterial agent chlorhexidine acetate, etc. However, due to their cationic properties, they cannot be used together with anionic surfactants. If they are added to cleaning products mainly composed of anionic surfactants, the two will react and lose their effectiveness, thus limiting the application of cationic surfactant-type antibacterial agents in cleaning products. Summary of the invention

[0008] The object of the present invention is to provide an antibacterial composition which does not add any preservatives and achieves its antibacterial effect only through the reasonable combination of surfactants.

[0009] The present invention finds that the anionic surfactant sodium laureth sulfate (AES), the zwitterionic surfactant cocamidopropyl betaine (CAB-35) and the amino acid anionic surfactant sodium lauroyl sarcosinate (LS-30) have obvious synergistic antibacterial effects through reasonable compatibility.

[0010] Therefore, the present invention first provides an antibacterial composition, which includes 5-8wt% sodium lauroyl sarcosinate, 5-8wt% cocamidopropyl betaine and 2-4wt% sodium laureth sulfate, and the pH value of the antibacterial composition is controlled at 4-5.5.

[0011] Furthermore, the antibacterial composition preferably includes 5-7wt% sodium lauroyl sarcosinate, 5-7wt% cocamidopropyl betaine and 3-4wt% sodium laureth sulfate, and the pH value of the antibacterial composition is controlled at 4.5-5.5.

[0012] Furthermore, in the antibacterial composition of the present invention, it is more preferred that the content of sodium lauroyl sarcosinate and cocamidopropyl betaine is the same.

[0013] An appropriate amount of sodium chloride can also be added to the antibacterial composition of the present invention to play a thickening role and to adjust the viscosity of the composition. The preferred amount of sodium chloride added is 0.5-1 wt%.

[0014] The present invention controls the pH value of the antibacterial composition by adding a small amount of inorganic acid or organic acid to the antibacterial composition, and there is no limitation on the inorganic acid or organic acid. However, the present invention preferably uses lactic acid to control the pH value of the antibacterial composition.

[0015] The antibacterial composition of the present invention does not contain any chemical antibacterial ingredients. Only through the mutual combination of different surfactants, an antibacterial composition with moderate viscosity and washing and decontamination effect is formed. The antibacterial rates of Candida albicans, Staphylococcus aureus and Escherichia coli under acidic conditions are all greater than 90%, and according to the provisions of GB 15979-2002, it has a strong antibacterial effect.

[0016] Based on the antibacterial composition of the present invention, other detergent ingredients can be further added to prepare various detergent and care products such as laundry detergent, hand soap, bath soap, private parts care liquid, etc., which have obvious antibacterial effects.

[0017] The antibacterial composition of the present invention can also be used in the preparation of cosmetics, and also has obvious antibacterial and antibacterial effects. Implementation

[0018] The specific implementation of the present invention is further described in detail below in conjunction with the examples. The following examples are only used to more clearly illustrate the technical solution of the present invention so that those skilled in the art can well understand and utilize the present invention, but not to limit the protection scope of the present invention.

[0019] The production processes, experimental methods or detection methods involved in the embodiments and comparative examples of the present invention are all conventional methods in the prior art unless otherwise specified, and their names and / or abbreviations are all conventional names in the field and are very clear and unambiguous in the relevant application fields. Technicians in the field can understand the conventional process steps based on the names and apply the corresponding equipment to implement them according to conventional conditions or the conditions recommended by the manufacturer.

[0020] The various instruments, equipment, raw materials or reagents used in the embodiments of the present invention are not particularly limited in terms of their sources, and are all conventional products that can be purchased through regular commercial channels, or can be prepared according to conventional methods well known to those skilled in the art.

[0021] The antibacterial performance in the examples of the present invention was carried out according to the C4 test method in Appendix C of GB 15979-2002, and the number of recovered bacteria in each test was controlled at 1×10 4 ~9×10 4 cfu / ml. Example

[0022] Example 1

[0023] Weigh 5.0 g LS-30, 5.0 g CAB-35, 3.0 g AES, and 0.5 g sodium chloride in turn and add them into a beaker, add 86.5 g deionized water, stir until completely dissolved and uniform, adjust the pH value of the solution to about 5 with lactic acid to prepare an antibacterial agent product.

[0024] Example 2

[0025] Weigh 7.0 g LS-30, 7.0 g CAB-35, 3.0 g AES, and 0.5 g sodium chloride in turn and add them into a beaker, add 82.5 g deionized water, stir until completely dissolved and uniform, adjust the pH value of the solution to about 5 with lactic acid to prepare an antibacterial agent product.

[0026] Example 3

[0027] Weigh 6.0 g LS-30, 6.0 g CAB-35, 3.0 g AES, and 0.5 g sodium chloride in turn and add them into a beaker, add 84.5 g deionized water, stir until completely dissolved and uniform, adjust the pH value of the solution to about 5 with lactic acid to prepare an antibacterial agent product.

[0028] Comparative Example 1

[0029] Weigh 3.0 g LS-30, 3.0 g CAB-35, 3.0 g AES, and 0.5 g sodium chloride in turn and add them into a beaker, add 90.5 g deionized water, stir until completely dissolved and uniform, adjust the pH value of the solution to about 5 with lactic acid to prepare an antibacterial agent product.

[0030] Comparative Example 2

[0031] Weigh 4.0 g LS-30, 4.0 g CAB-35, 3.0 g AES, and 0.5 g sodium chloride in turn and add them into a beaker, add 88.5 g deionized water, stir until completely dissolved and uniform, adjust the pH value of the solution to about 5 with lactic acid to prepare an antibacterial agent product.

[0032] Referring to the method in Appendix C of GB 15979-2002, the antibacterial performance of the products of Examples 1 to 3 and Comparative Examples 1 to 2 was tested. After 10 minutes of action, the antibacterial rates of Candida albicans, Escherichia coli and Staphylococcus aureus were tested respectively. The specific results are listed in Table 1.

[0033]

[0034] The test results show that the products of Examples 1 to 3 all have strong antibacterial effects and moderate viscosity. As the amount of CAB-35 and LS-30 added in the comparative example decreases, its antibacterial effect also gradually decreases, but increasing the content has no significant change on the antibacterial effect.

[0035] Example 4

[0036] Weigh 5.0g LS-30, 5.0g CAB-35, 3.0g AES, 2.0g APG1214, 5.0g MAPK30, and 0.5g sodium chloride in turn and add them into a beaker, add 79.5g deionized water, stir until completely dissolved, adjust the pH value of the solution to about 5 with lactic acid, and prepare an antibacterial hand sanitizer product.

[0037] After testing, the product's active ingredient content is 7.52, which meets the relevant standards such as ordinary hand sanitizer (GB / T 34857-2017) and bath agent (GB / T34857-2017).

[0038] The antibacterial performance of the product was tested, and the antibacterial rates against Escherichia coli, Staphylococcus aureus and Candida albicans were 99.9%, 100.0% and 99.9%, respectively. Compared with Example 1, adding the anionic surfactant MAPK30 and the nonionic surfactant APG1214 to the product did not have a negative impact on the antibacterial effect of the product.

[0039] Comparative Example 3

[0040] 13.0 g LS-30, 13.0 g CAB-35 and 13.0 g AES were weighed respectively, added into 87 g deionized water and stirred to dissolve evenly, the pH value was adjusted to 5 with lactic acid, and the antibacterial properties of each solution were tested.

[0041]

[0042] According to the above test results, when the pH is about 5:

[0043] 1. The antibacterial rate of 13% CAB-35 aqueous solution against Staphylococcus aureus and Escherichia coli is greater than 50% but less than 90%, and it has no antibacterial effect on Candida albicans.

[0044] 2. The antibacterial rate of 13% LS-30 aqueous solution against Candida albicans is greater than 90%, and the antibacterial rate against Staphylococcus aureus and Escherichia coli is greater than 50% but less than 90%.

[0045] 3. The antibacterial rate of 13% AES aqueous solution against Staphylococcus aureus is greater than 90%, but it has basically no antibacterial effect on Escherichia coli and Candida albicans.

[0046] Therefore, from the above results, it can be seen that there are large differences in the antibacterial rates of a single surfactant against Staphylococcus aureus, Escherichia coli and Candida albicans, but it is impossible to achieve an antibacterial effect of more than 90% at the same time.

[0047] Comparative Example 4

[0048] 5.0 g LS-30, 5.0 g CAB-35 and 3.0 g AES were weighed in turn and added into a beaker. 87 g deionized water was added and stirred until completely dissolved. The pH value of the solution was adjusted to 5, 6 and 7 respectively, and the antibacterial properties of each solution were tested.

[0049]

[0050] The test results show that the antibacterial agent product made of three surfactants can achieve an antibacterial rate of 99.9% against three kinds of bacteria at a pH of 5, but the antibacterial effect gradually decreases with the increase of pH value. This may be because under acidic conditions, the amphoteric surfactant CAB-35 and the amino acid anionic surfactant LS-30 will show cationic properties and have a strong antibacterial effect. Therefore, it is recommended that the pH value of the compound system be kept at around 5.

[0051] Comparative Example 5

[0052] Weigh 0.2 g of chlorhexidine acetate and 3.0 g of AES into a beaker, add 90 g of deionized water, stir until completely dissolved, adjust the pH value of the solution to about 5 with lactic acid, add water to 100 g, and prepare an antibacterial agent product.

[0053] The antibacterial properties of the product were tested using a cationic medical bactericide 0.2% chlorhexidine acetate aqueous solution as a control. The results showed that 0.2% chlorhexidine acetate aqueous solution had a significant inhibitory effect on various pathogens. The inhibition rates of Escherichia coli, Staphylococcus aureus and Candida albicans were 99.9%, 100.0% and 99.5%, respectively, all greater than 90%.

[0054] However, after adding the anionic surfactant AES to the 0.2% chlorhexidine acetate aqueous solution, its antibacterial effect was significantly reduced, and the inhibition rates against Escherichia coli, Staphylococcus aureus and Candida albicans were reduced to 57.2%, 64.3% and 45.9%, respectively.

[0055] The above embodiments of the present invention do not describe all the details in detail, nor limit the present invention to the above embodiments. Various changes, modifications, substitutions and variations made by ordinary technicians in this field without departing from the principles and purpose of the present invention should be included in the protection scope of the present invention.

Claims

1. An antibacterial composition comprising 5-8wt% sodium lauroyl sarcosinate, 5-8wt% cocamidopropyl betaine and 2-4wt% sodium laureth sulfate, wherein the pH value of the antibacterial composition is controlled at 4-5.

5.

2. The antibacterial composition according to claim 1, comprising 5-7wt% sodium lauroyl sarcosinate, 5-7wt% cocamidopropyl betaine and 3-4wt% sodium laureth sulfate, and the pH value of the antibacterial composition is controlled at 4.5-5.

5.

3. The antibacterial composition according to claim 1 or 2, wherein sodium lauroyl sarcosinate and cocamidopropyl betaine have the same content.

4. The antibacterial composition according to claim 1, 2 or 3, characterized in that It also includes 0.5-1wt% sodium chloride.

5. The antibacterial composition according to claim 1, 2 or 3, characterized in that Lactic acid was used to control pH.

6. Use of the antibacterial composition according to claim 1 in the preparation of washing and care products.

7. The use according to claim 6, wherein the washing and care products are laundry detergent, hand soap, shower gel or private parts care liquid.

8. Use of the antibacterial composition according to claim 1 in the preparation of cosmetics.

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