Cold medicament for treating cold and preparation method thereof

Abstract

The invention discloses a cold medicament for treating cold and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 15 parts of folium artemisiae argyi, 10 to 35 parts of herba schizonepetae, 15 to 20 parts of herba pogostemonis, 14 to 18 parts of herba elsholtziae, 8 to 10 parts of herba rabdosiae, 15 to 30 parts of radix saposhnikoviae, 2 to 5 parts of stiff silkworm, 20 to 25 parts of herba menthae, 5 to 15 parts of rhizoma paridis, 30 to 50 parts of echinacea purpurea, 5 to 10 parts of honey-fried licorice root, 10 to 12 parts of fructus crataegi and 5 to 7 parts of flos lonicerae. The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition. The traditional Chinese medicine composition has the effects of quickly taking effect, reconciling superficies and interior, soothing liver, raising yang, dispelling wind and heat, diminishing swelling, detoxifying, inducing diuresis, removing dampness, resisting bacteria, resisting viruses, improving the immunity of the organism, cooling blood and relieving sore-throat, treats both symptoms and root causes, has a better effect on various diseases, and is not easy to relapse after being treated.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a cold medicine for treating colds and a preparation method thereof. Background Art

[0002] Cold is a common disease caused by influenza virus. It is mainly divided into common cold and influenza. Symptoms include fever, headache, muscle pain, runny nose, sore throat, etc. Cold may seem like a "minor illness", but if it is not treated in time, it can easily lead to a variety of serious complications, such as viral myocarditis, etc., and in severe cases, it may be life-threatening. Influenza is especially common among them. It is an acute respiratory infectious disease caused by influenza virus with high incidence, wide spread and rapid spread. In 1918, 1957 and 1968, three major influenza epidemics broke out in the world, and tens of millions of people were killed by influenza. Because the surface antigens of influenza virus, hemagglutinin HA and neuraminidase NA, can mutate frequently, there are many types of cold viruses, which brings certain difficulties to the use of vaccines to prevent influenza. At present, the number of people suffering from colds is increasing, and there are several influenza attacks every winter and spring, so the application of cold medicine has a broad market prospect.

[0003] Cold medicine refers to a variety of medicines used to treat colds, including Chinese patent medicines, decoctions, Western medicines, granules, etc. At present, most cold medicines are compound preparations. Commonly used formulas include: antipyretic analgesics, nasal mucosal vasoconstrictors, histamine antagonists, central nervous system stimulants, and antiviral drugs. Colds are a common disease in all seasons and can recur. Although they are self-limiting diseases, most patients choose to take medication for treatment. Therefore, anti-cold medicines occupy an important position in the huge domestic pharmaceutical market and are a type of medicine that no manufacturer can ignore. The symptoms of colds are usually multifaceted. Compound preparations can target multiple diseases at the same time and have the advantage of symptom control. They have gradually become the mainstream products on the market. Therefore, good compound therapeutic drugs are still the focus of new cold drug development and market hotspots.

[0004] Most of the existing cold medicines can only temporarily relieve cold symptoms, but they cannot cure the root cause. They are often only effective for certain symptoms, and are prone to relapse after treatment. They cannot play a fundamental therapeutic role for most patients. In addition, the existing cold medicines have defects such as slow effect and inconvenience in taking, which are not conducive to wide promotion and popularization. Summary of the invention

[0005] In view of the deficiencies in the prior art, the present invention provides a cold medicine for treating colds and a preparation method thereof, which solves the problem that most of the existing cold medicines can only temporarily alleviate cold symptoms, but do not cure the root cause, and are often only effective for certain symptoms, and are prone to relapse after treatment, and cannot play a fundamental therapeutic role for most patients. In addition, the existing cold medicines have the defects of slow effect and inconvenience in taking, which are not conducive to wide promotion and popularization.

[0006] To achieve the above objectives, the present invention is implemented through the following technical scheme: a cold medicine for treating colds, the raw materials are composed of the following by weight: 10-15 parts by weight of wormwood, 10-35 parts by weight of schizonepeta, 15-20 parts by weight of patches, 14-18 parts by weight of elsholtzia, 8-10 parts by weight of rubescens, 15-30 parts by weight of siler, 2-5 parts by weight of bombyx batryticatus, 20-25 parts by weight of mint, 5-15 parts by weight of parsley, 30-50 parts by weight of echinacea, 5-10 parts by weight of licorice, 10-12 parts by weight of hawthorn, 5-7 parts by weight of honeysuckle, 20-25 parts by weight of kudzu root, 15-20 parts by weight of platycodon, and 3-8 parts by weight of notoginseng flower.

[0007] Artemisia argyi: This product is the dried leaves of the Asteraceae plant Artemisia argyi; it is pungent, bitter, and warm in nature; it enters the liver, spleen, and stomach meridians; it dispels cold and relieves pain, warms the meridians and stops bleeding;

[0008] Nepeta: It is the dried aerial part of Nepeta, an annual herbaceous plant of the Lamiaceae family. Nepeta was first recorded in the Shennong's Herbal Classic as "false Su" and was listed as a medium-grade product; the name Nepeta was first recorded in the Wu Pu's Herbal Classic. Nepeta is warm in nature and pungent in taste, and some people also think it is neutral or cool in nature; its raw product has the effects of dispelling wind and relieving exterior symptoms, dispelling toxins and relieving rashes, dispersing blood stasis and stopping bleeding, and is mainly used to treat colds, sore throats and various skin diseases;

[0009] Patchouli: This product is the whole herb of the plant Patchouli or Patchouli of the Lamiaceae family; it is pungent and slightly warm in nature; it enters the lung, spleen, and stomach meridians; it dispels heat and relieves exterior symptoms; it eliminates dampness and soothes the stomach;

[0010] Elsholtzia: This product is the dried aerial part of the plant Elsholtzia of the Lamiaceae family; it is pungent and slightly warm in nature; it enters the lung and stomach meridians; it can induce sweating and relieve exterior symptoms, and harmonize the middle and eliminate dampness;

[0011] Rabdosia rubescens: This product is a plant of the genus Rubus in the Lamiaceae family; it is bitter, sweet, and slightly cold in nature; it can clear away heat and detoxify, promote blood circulation and relieve pain;

[0012] Saposhnikovia root: pungent, sweet, warm. Enters the bladder, liver, and spleen meridians. Functions: dispelling wind, removing dampness, and stopping spasms. Used for colds and headaches, rheumatic pain, urticaria itching, and tetanus.

[0013] Bombyx Batryticatus: pungent and salty in nature and flavor, neutral. Enters the liver, lung and stomach meridians. Efficacy: dispels wind and relieves spasms, resolves phlegm and disperses stagnation. Treats aphonia caused by stroke, epilepsy, head wind, throat wind, throat paralysis, scrofula and tuberculosis.

[0014] Peppermint: pungent, cool. Enters the lung meridian and liver meridian. Disperses wind-heat, clears the head, relieves sore throat and rashes, soothes the liver and promotes qi. Modern medicine has proven that peppermint can treat colds, headaches, sore throats, mouth sores, rubella, measles, chest and abdominal distension, and has anti-inflammatory and analgesic effects.

[0015] Paris polyphylla: cool in nature, slightly bitter. Slightly toxic, enters the heart meridian, liver meridian, lung meridian, stomach meridian, and large intestine meridian; Paris polyphylla has the effects of anti-cancer, swelling and pain relief, detoxification and heat clearing, calming the nerves and relieving asthma, and antitussive; its main functions are clearing away heat and detoxification, swelling and pain relief. Modern pharmacological studies have shown that Paris polyphylla has a strong antibacterial effect on influenza A virus, and has antibacterial ability against Salmonella, Salmonella paratyphi, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, hemolytic Streptococcus, meningococcus, Shigella dysenteriae and other bacteria.

[0016] Echinacea: It has immune-enhancing effects and contains a variety of active ingredients that can stimulate the activity of immune cells such as white blood cells in the human body and improve immunity; Echinacea is used for antiviral, antibacterial and anti-inflammatory, anti-tumor, prevention of colds, coughs and treatment of upper respiratory tract infections.

[0017] Roasted Licorice: Enters the spleen, stomach and lung meridians. Mainly used to soothe the stomach and relieve urgency, moisten the lungs, detoxify, and harmonize various medicines. Roasted, it can treat spleen and stomach weakness, poor appetite, abdominal pain and loose stools, fatigue and fever, pulmonary tuberculosis and cough, palpitations, and epilepsy; raw, it can treat sore throat, peptic ulcer, carbuncle, and ulcer, and detoxify drug poisoning and food poisoning;

[0018] Hawthorn: sour and sweet in nature, slightly warm, enters the spleen meridian, stomach meridian, and liver meridian, mainly treats digestion and stomachic invigoration, promoting qi and dispersing blood stasis, and expelling tapeworms. It can treat meat stagnation, abdominal masses, phlegm and fluid retention, acid regurgitation, intestinal wind, back pain, lochia retention, milk and food stagnation in children, gastric stagnation, diarrhea and abdominal pain, blood stasis and amenorrhea, postpartum blood stasis, heart and abdomen stabbing pain, hernia pain, and hyperlipidemia. Raw hawthorn is used to digest food and dissipate blood stasis, and charred hawthorn is used to stop diarrhea and dysentery;

[0019] Honeysuckle: sweet and cold in nature, enters the lung and stomach meridians, mainly treats exogenous wind-heat or fever due to febrile diseases, heatstroke, heat-toxic bloody diarrhea, carbuncle, throat paralysis, and various infectious diseases;

[0020] Pueraria root: cool in nature, sweet and spicy in taste, mainly used for: thirst, fever, various diseases, raising yin energy, and removing toxins. Strengthen the immune function of liver and gallbladder cells and resist virus invasion;

[0021] Platycodon grandiflorum: It can invigorate the lungs, resolve phlegm and discharge pus, and can be used for chest, diaphragm and throat, regardless of whether the lungs are hot or cold.

[0022] Notoginseng flower: sweet and cool in nature, with the effects of clearing heat, calming the liver, and lowering blood pressure. It is suitable for dizziness, vertigo, tinnitus, hypertension and acute pharyngitis. It also has certain effects on sleep. It has a slight smell, sweet and slightly bitter taste, lowers blood lipids, lowers blood pressure, fights cancer, improves myocardial oxygen supply, and enhances the body's immune function. It contains a variety of ginseng saponins, calms the liver, lowers blood pressure, and prevents and treats hypertension and pharyngitis. It can clear heat and detoxify, remove acne and sores, calm the liver and cool blood, lower blood pressure and lipids. Notoginseng flower is cool in nature and sweet in taste, and has the effects of clearing heat, calming the liver, and lowering blood pressure. Notoginseng flower total saponins have an inhibitory effect on the central nervous system, showing sedative and tranquilizing effects. It is mainly used as an effective ingredient for clearing heat, detoxifying, cooling blood, lowering blood pressure, regulating lipids, immune regulation, promoting blood circulation and unblocking meridians, health preservation and anti-aging, and anti-inflammatory and analgesic effects. It has significant effects of calming the liver, removing phlegm, calming asthma, analgesic and sleeping, expanding the crown, anti-allergic, detoxification and beauty.

[0023] A method for preparing a cold medicine for treating a cold comprises the following steps:

[0024] Step 1: Soak and wash the Chinese medicinal materials of wormwood leaf, schizonepeta, patchouli, elsholtzia, rubescens, saposhnikovia, bombyx batryticatus, mint, parsley, echinacea, licorice root, hawthorn, honeysuckle, kudzu root, platycodon grandiflorum, and notoginseng flower in clean water, and then soak them in sodium chloride solution;

[0025] Step 2: Take out the wormwood leaf, patchouli, elsholtzia, honeysuckle, bombyx batryticatus, and licorice root in step 1, wash, dry, grind, and pass through a 100-mesh sieve to obtain fine powder for later use;

[0026] Step 3: Take out the Nepeta, wash, dry, and prepare Nepeta volatile oil for later use;

[0027] Step 4: Take out the kudzu root, platycodon, siler, mint and echinacea, wash and dry them, and extract the kudzu root, platycodon, siler, mint and echinacea by supercritical carbon dioxide extraction, and set aside the extract;

[0028] Place the drug residue in an oven at 75°C to 90°C and dry it for later use;

[0029] Step 5: Mix hawthorn, rubescens, and Paris polyphylla with the medicinal residues in the above-mentioned weight ratio, crush them to obtain a mixture, extract them using an extraction-azeotropic distillation coupling extraction device, put the mixture in a flask, add water for extraction, and set aside the extract;

[0030] Step 6: combining the extract and the extractant, adding an ethanol solution accounting for 20% of the volume of the extract and the extractant to combine the extract and the extractant, and performing a first concentration;

[0031] After cooling, 10% of the ethanol of the first concentrated volume is added, and the fine powder in step 2 and the volatile oil of Nepeta tenuifolia in step 3 are added to carry out a second concentration to obtain the effective components of the cold medicine.

[0032] Preferably, in step one, the temperature of the clean water is set to be lower than 18° C., the soaking time in the clean water is set to 2 min to 5 min, and ultrasound is used for 30 s to remove dust and fine sand on the medicinal materials while soaking in the clean water. The mass concentration of the sodium chloride solution in step one is set to 0.15%-0.20%, and the soaking time is set to 30 min.

[0033] Preferably, the grinding in step 2 is carried out by mixed grinding with a pulverizer, so that the grinding and mixing operations can be carried out simultaneously, and the grinding speed of the pulverizer is set to 100r / min.

[0034] Preferably, the method for preparing schizonepeta volatile oil in step 3 comprises the following steps:

[0035] Step 1: Weigh Nepeta tenuifolia according to the above weight, add 8 to 12 times of water, and steam distill for 2 to 8 hours;

[0036] Step 2: using an oil-water separator to separate the aqueous schizonepeta volatile oil;

[0037] Step 3: Freeze at -9 to 15°C for 6 to 36 hours, remove ice and water, and obtain Nepeta tenuifolia volatile oil.

[0038] Preferably, in step 4, the extraction pressure is set to 50-80 MPa, the extraction temperature is set to 45-60° C., and the extraction time is set to 360-600 min.

[0039] Preferably, in step 5, pure water is used, the weight of which is set to 10-20 times the weight of the added medicinal materials, the soaking time is set to 120 minutes, and the extraction time is set to 480-720 minutes.

[0040] Preferably, in step 6, the first concentration time is set to 60 minutes, and the concentration temperature is set to 50° C.;

[0041] The second concentration time in step six is ​​set to 30 minutes, and the relative density is 1.0093-1.1490 g / cm3 when concentrated to 80°C.

[0042] The present invention provides an oral therapeutic agent for treating chronic gastritis and a preparation process thereof. The agent has the following beneficial effects:

[0043] 1. The present invention has the effects of fast effect, reconciliation of exterior and interior, soothing liver and raising yang, evacuating wind-heat, reducing swelling and detoxification, diuresis and dehumidification, antibacterial and antiviral, improving body immunity, cooling blood and relieving sore throat, and treating both the symptoms and the root causes, has a good effect on various diseases, and is not easy to relapse after treatment.

[0044] 2. The present invention can improve the patient's appetite during a cold by increasing the proportion of hawthorn in the preparation of cold medicines, avoid consuming visceral fat and more protein due to not eating during a cold, which leads to a decrease in the body's resistance and excessive eating in the later stage, which has a very adverse effect on the body. By increasing the appetizing effect of the cold medicine, the patient's normal daily energy intake is guaranteed, which is beneficial to ensuring the patient's stomach health and maintaining physical health.

[0045] 3. The present invention combines the cold medicine with appropriate auxiliary materials to cover up the bad smell and taste of the medicine, prevent the medicine from being inactivated in the stomach, reduce the stimulation to the gastric mucosa, and improve the stability of the medicine. DETAILED DESCRIPTION

[0046] The following specific embodiments further describe the present invention in detail. The embodiments of the present invention are provided for the purpose of illustration and description, and are not intended to be exhaustive or to limit the present invention to the disclosed forms. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiments are selected and described to better illustrate the principles and practical applications of the present invention, and to enable those of ordinary skill in the art to understand the present invention and thereby design various embodiments with various modifications suitable for specific uses.

[0047] Example 1, a cold medicine for treating colds, the raw material composition is calculated by weight: 15 parts by weight of wormwood, 35 parts by weight of schizonepeta, 20 parts by weight of Patchouli, 18 parts by weight of Elsholtzia, 10 parts by weight of Rubescens, 30 parts by weight of Saposhnikovia, 5 parts by weight of Bombyx Batryticatus, 25 parts by weight of mint, 15 parts by weight of Paris polyphylla, 50 parts by weight of Echinacea, 10 parts by weight of Radix Glycyrrhizae Preparata, 12 parts by weight of Hawthorn, 7 parts by weight of Flos Lonicerae, 25 parts by weight of Puerariae, 20 parts by weight of Platycodon grandiflorum, 8 parts by weight of Notoginseng flower. .

[0048] Example 2, a cold medicine for treating colds, the raw material composition is calculated by weight: 12.5 parts by weight of wormwood, 22.5 parts by weight of schizonepeta, 17.5 parts by weight of patches, 16 parts by weight of elsholtzia, 9 parts by weight of rubescens, 22.5 parts by weight of siler, 3.5 parts by weight of bombyx batryticatus, 22.5 parts by weight of mint, 10 parts by weight of parsley, 40 parts by weight of echinacea, 7.5 parts by weight of roasted licorice, 11 parts by weight of hawthorn, 6 parts by weight of honeysuckle, 22.5 parts by weight of kudzu root, 17.5 parts by weight of platycodon, and 5.5 parts by weight of notoginseng flower.

[0049] Example 3, a cold medicine for treating colds, the raw material composition is calculated by weight: 15 parts by weight of wormwood, 35 parts by weight of schizonepeta, 20 parts by weight of patches, 18 parts by weight of elsholtzia, 10 parts by weight of rubescens, 30 parts by weight of siler, 5 parts by weight of bombyx batryticatus, 25 parts by weight of mint, 15 parts by weight of parsley, 50 parts by weight of echinacea, 10 parts by weight of roasted licorice, 12 parts by weight of hawthorn, 7 parts by weight of honeysuckle, 25 parts by weight of kudzu root, 20 parts by weight of platycodon, and 8 parts by weight of Panax notoginseng flower.

[0050] Embodiment 4, based on Embodiment 1, Embodiment 2 and Embodiment 3, a method for preparing a cold medicine for treating a cold comprises the following steps:

[0051] Step 1: Soak and wash the Chinese medicinal materials of wormwood leaf, schizonepeta, patchouli, elsholtzia, rubescens, saposhnikovia, bombyx batryticatus, mint, parsley, echinacea, licorice root, hawthorn, honeysuckle, kudzu root, platycodon grandiflorum, and notoginseng flower in clean water, and then soak them in sodium chloride solution;

[0052] Step 2: Take out the wormwood leaf, patchouli, elsholtzia, honeysuckle, bombyx batryticatus, and licorice root in step 1, wash, dry, grind, and pass through a 100-mesh sieve to obtain fine powder for later use;

[0053] Step 3: Take out the Nepeta, wash, dry, and prepare Nepeta volatile oil for later use;

[0054] Step 4: Take out the kudzu root, platycodon, siler, mint and echinacea, wash and dry them, and extract the kudzu root, platycodon, siler, mint and echinacea by supercritical carbon dioxide extraction, and set aside the extract;

[0055] Place the drug residue in an oven at 75°C to 90°C and dry it for later use;

[0056] Step 5: Mix hawthorn, rubescens, and Paris polyphylla with the medicinal residues in the above-mentioned weight ratio, crush them to obtain a mixture, extract them using an extraction-azeotropic distillation coupling extraction device, put the mixture in a flask, add water for extraction, and set aside the extract;

[0057] Step 6: combining the extract and the extractant, adding an ethanol solution accounting for 20% of the volume of the extract and the extractant to combine the extract and the extractant, and performing a first concentration;

[0058] After cooling, 10% of the ethanol of the first concentrated volume is added, and the fine powder in step 2 and the volatile oil of Nepeta tenuifolia in step 3 are added to carry out a second concentration to obtain the effective components of the cold medicine.

[0059] In the step 1, the temperature of the clean water is set to be lower than 18° C., the soaking time in the clean water is set to 2 min to 5 min, and while soaking in the clean water, ultrasound is used for 30 s to remove dust and fine sand on the medicinal materials. In the step 1, the mass concentration of the sodium chloride solution is set to 0.15%-0.20%, and the soaking time is set to 30 min.

[0060] The grinding in step 2 is carried out by mixing and pulverizing with a pulverizer, so that the pulverizing and mixing operations can be carried out simultaneously, and the pulverizing speed of the pulverizer is set to 100 r / min.

[0061] The method for preparing schizonepeta volatile oil in step 3 comprises the following steps:

[0062] Step 1: Weigh Nepeta tenuifolia according to the above weight, add 8 to 12 times of water, and steam distill for 2 to 8 hours;

[0063] Step 2: using an oil-water separator to separate the aqueous schizonepeta volatile oil;

[0064] Step 3: Freeze at -9 to 15°C for 6 to 36 hours, remove ice and water, and obtain Nepeta tenuifolia volatile oil.

[0065] In the step 4, the extraction pressure is set to 50-80 MPa, the extraction temperature is set to 45-60° C., and the extraction time is set to 360-600 min.

[0066] In the step 5, pure water is used, the weight of which is set to be 10-20 times the weight of the added medicinal materials, the soaking time is set to be 120 minutes, and the extraction time is set to be 480-720 minutes.

[0067] In step 6, the first concentration time is set to 60 minutes, and the concentration temperature is set to 50° C.;

[0068] The second concentration time in step 6 is set to 30 minutes, and the relative density is 1.0093-1.1490 g / cm3 when concentrated to 80°C.

[0069] Toxicity test

[0070] The test drug is the drug in Example 1 of the present invention. The test animals are ICR mice, weighing 20 to 245 grams, half male and half female, a total of 40. The test method is that after fasting for 15 hours, the mice are gavaged at 20 grams / kg per day for 3 months. The results of the long-term toxicity test show that there is no significant difference between the weight, liver function, kidney function, blood count, etc. of the mice and the control group, indicating that the safety of the drug is high and belongs to the non-toxic level.

[0071] Drug effect experiment

[0072] Experimental materials: finished cold medicine of the present invention;

[0073] Experimental animals: ICR mice;

[0074] Virus strains used in the experiment: influenza A virus and influenza B virus, provided by the Institute of Virology, Chinese Academy of Preventive Medicine.

[0075] Effects on the lung index of mice infected with influenza A virus and influenza B virus:

[0076] Take 100 ICR mice, weighing 13-16g, half ♂♀. Randomly divide into 5 groups, 20 mice in each group. All the mice in the above groups were gavaged, with a gavage capacity of 20ml / kg once a day × 7 days. On the third day of administration, each group of mice (except the blank control group) was infected with viral allantoic fluid drops in the nose under light ether anesthesia, 30ul (15 LD50 attack doses) per mouse. Continue to administer the medicine for 4 days. Fasting but not water before the experiment. On the day of the experiment, weigh the mice in each group, dislocate the neck and kill them. Dissect and observe the lung lesions. Take the whole lung and weigh it, calculate the lung index value of each mouse, the lung index inhibition rate, compare the differences between the groups, and take the lungs and fix them with 10% formaldehyde for pathological histological examination.

[0077]

[0078]

[0079] Compared with the virus control group, the experimental results show:

[0080] The 5mg / kg, 10mg / kg and 20mg / kg dosage groups of this drug can significantly reduce the lung index values ​​of mice infected with influenza A virus, and the lung index inhibition rates are 24.40%, 29.89% and 34.19, indicating that Jingan Capsule has the effect of alleviating lung lesions in mice infected with influenza A virus.

[0081] Pathological histological examination results:

[0082] Model group: All lung tissues in this group showed moderate to severe bronchitis and interstitial pneumonia, and congestion and bleeding were more obvious. One-third of the lung tissues showed mild to moderate alveolitis. It showed degeneration and necrosis of bronchial epithelial cells, and necrotic cells and exudates were seen in the cavity. The structure of the diseased bronchial wall and the surrounding lung tissue was unclear, with a large number of lymphocytes, macrophages and a small number of neutrophils infiltrating. The alveolar wall was generally thickened, the blood vessels inside were dilated, and there were varying numbers of the above-mentioned inflammatory cells infiltrating, and apoptotic bodies were seen in the alveoli of some lung tissues.

[0083] Low-dose group: The lung tissues in this group also showed mild to moderate bronchitis and interstitial pneumonia, with a few cases being more severe. However, the overall degree of lesions was milder than that of the model group.

[0084] Medium-dose group: The lesion morphology in this group was similar to that in the low-dose group, and the overall lesion severity was slightly milder.

[0085] High-dose group: The lesion morphology of this group was similar to that of the above groups, but the overall degree of lesions was significantly lighter than that of the above groups. Three cases were basically normal.

[0086] in conclusion:

[0087] Influenza A virus and influenza B virus infection successfully replicated pneumonia lesions in mice. The main manifestations were bronchitis and interstitial pneumonia. Nepeta has the effect of resisting lung infection caused by influenza B virus, and the high dose has better efficacy.

[0088] The technical solution of the present invention is not limited to the above-mentioned specific embodiments. All technical variations made according to the technical solution of the present invention fall within the protection scope of the present invention.

[0089] Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field and related fields without creative work should fall within the scope of protection of the present invention. The structures, devices and operating methods not specifically described and explained in the present invention are implemented according to the conventional means in the field unless otherwise specified and limited.

Claims

1. A cold medicine for treating colds, characterized in that: The raw material composition is calculated by weight as follows: 10-15 parts by weight of wormwood, 10-35 parts by weight of schizonepeta, 15-20 parts by weight of patches, 14-18 parts by weight of elsholtzia, 8-10 parts by weight of rubescens, 15-30 parts by weight of siler, 2-5 parts by weight of bombyx batryticatus, 20-25 parts by weight of mint, 5-15 parts by weight of parsley, 30-50 parts by weight of echinacea, 5-10 parts by weight of roasted licorice, 10-12 parts by weight of hawthorn, 5-7 parts by weight of honeysuckle, 20-25 parts by weight of kudzu root, 15-20 parts by weight of platycodon, and 3-8 parts by weight of notoginseng flower.

2. A cold medicine for treating colds according to claim 1, characterized in that: The raw material composition is calculated in parts by weight: 12.5 parts by weight of wormwood, 22.5 parts by weight of schizonepeta, 17.5 parts by weight of patches, 16 parts by weight of elsholtzia, 9 parts by weight of rubescens, 22.5 parts by weight of siler, 3.5 parts by weight of bombyx batryticatus, 22.5 parts by weight of mint, 10 parts by weight of parsley, 40 parts by weight of echinacea, 7.5 parts by weight of roasted licorice, 11 parts by weight of hawthorn, 6 parts by weight of honeysuckle, 22.5 parts by weight of kudzu root, 17.5 parts by weight of platycodon, and 5.5 parts by weight of notoginseng flower.

3. A method for preparing a cold medicine for treating colds, characterized in that: The following steps are involved: Step 1: Soak and wash the Chinese medicinal materials of wormwood leaf, schizonepeta, patchouli, elsholtzia, rubescens, saposhnikovia, bombyx batryticatus, mint, parsley, echinacea, licorice root, hawthorn, honeysuckle, kudzu root, platycodon grandiflorum, and notoginseng flower in clean water, and then soak them in sodium chloride solution; Step 2: Take out the wormwood leaf, patchouli, elsholtzia, honeysuckle, bombyx batryticatus, and licorice root in step 1, wash, dry, grind, and pass through a 100-mesh sieve to obtain fine powder for later use; Step 3: Take out the Nepeta, wash, dry, and prepare Nepeta volatile oil for later use; Step 4: Take out the kudzu root, platycodon, siler, mint and echinacea, wash and dry them, and extract the kudzu root, platycodon, siler, mint and echinacea by supercritical carbon dioxide extraction, and set aside the extract; Place the drug residue in an oven at 75°C to 90°C and dry it for later use; Step 5: Mix hawthorn, rubescens, and Paris polyphylla with the medicinal residues in the above-mentioned weight ratio, crush them to obtain a mixture, extract them using an extraction-azeotropic distillation coupling extraction device, put the mixture in a flask, add water for extraction, and set aside the extract; Step 6: combining the extract and the extractant, adding an ethanol solution accounting for 20% of the volume of the extract and the extractant to combine the extract and the extractant, and performing a first concentration; After cooling, 10% of the ethanol of the first concentrated volume is added, and the fine powder in step 2 and the volatile oil of Nepeta tenuifolia in step 3 are added to carry out a second concentration to obtain the effective components of the cold medicine.

4. The method for preparing a cold medicine for treating colds according to claim 3, characterized in that: In the step 1, the temperature of the clean water is set to be lower than 18° C., the soaking time in the clean water is set to 2 min to 5 min, and while soaking in the clean water, ultrasound is used for 30 s to remove dust and fine sand on the medicinal materials. In the step 1, the mass concentration of the sodium chloride solution is set to 0.15%-0.20%, and the soaking time is set to 30 min.

5. The method for preparing a cold medicine for treating colds according to claim 3, characterized in that: The grinding in step 2 is carried out by mixing and pulverizing with a pulverizer, so that the pulverizing and mixing operations can be carried out simultaneously, and the pulverizing speed of the pulverizer is set to 100 r / min.

6. The method for preparing a cold medicine for treating colds according to claim 3, characterized in that: The method for preparing schizonepeta volatile oil in step 3 comprises the following steps: Step 1: Weigh Nepeta tenuifolia according to the above weight, add 8 to 12 times of water, and steam distill for 2 to 8 hours; Step 2: using an oil-water separator to separate the aqueous schizonepeta volatile oil; Step 3: Freeze at -9 to 15°C for 6 to 36 hours, remove ice and water, and obtain Nepeta tenuifolia volatile oil.

7. The method for preparing a cold medicine for treating colds according to claim 3, characterized in that: In the step 4, the extraction pressure is set to 50-80 MPa, the extraction temperature is set to 45-60° C., and the extraction time is set to 360-600 min.

8. The method for preparing a cold medicine for treating colds according to claim 3, characterized in that: In the step 5, pure water is used, the weight of which is set to be 10-20 times the weight of the added medicinal materials, the soaking time is set to be 120 minutes, and the extraction time is set to be 480-720 minutes.

9. The method for preparing a cold medicine for treating colds according to claim 3, characterized in that: In step 6, the first concentration time is set to 60 minutes, and the concentration temperature is set to 50° C.; The second concentration time in step six is ​​set to 30 minutes, and the relative density is 1.0093-1.1490 g / cm3 when concentrated to 80°C.

Images