Non-endoscope-mediated localizable instant esophageal mucosa impedance detection system

Abstract

The invention discloses a non-endoscope-mediated locatable instant esophageal mucosa impedance detection system which comprises a catheter assembly, and a real-time mucosa impedance detection module, a real-time pressure monitoring module, a real-time pH monitoring module, a signal processing module and a high-resolution signal display module which are mounted on the catheter assembly, the catheter assembly is inserted into the esophagus through the nasal cavity, and in the insertion process, whether the catheter assembly is inserted into a preset position or not is judged through the real-time pressure monitoring module and the real-time pH monitoring module. According to the non-endoscope-mediated locatable instant esophageal mucosa impedance detection system disclosed by the invention, linkage is carried out through the catheter assembly, the real-time mucosa impedance detection module, the real-time pressure monitoring module, the real-time pH monitoring module, the signal processing module and the high-resolution signal display module, endoscope mediation and anesthesia are not needed, and the real-time pressure monitoring module, the real-time pH monitoring module, the signal processing module and the high-resolution signal display module are linked; the esophageal mucosa impedance value and the esophageal pH value can be detected in real time, and a basis is provided for diagnosing the gastroesophageal reflux disease.

Description

Technical Field

[0001] The present invention belongs to the technical field of esophageal data detection, and in particular relates to a non-endoscope-mediated real-time esophageal mucosal impedance detection system that can be positioned. Background Art

[0002] Esophageal mucosal impedance technology can diagnose gastroesophageal reflux disease and eosinophilic esophagitis. Many clinical studies have clearly shown that the basic value of mucosal impedance reflects the permeability of the esophageal mucosa. The baseline values ​​of esophageal mucosal impedance in erosive and non-erosive gastroesophageal reflux are low. Esophageal mucosal impedance is related to changes in intercellular spaces and tight junctions and reflux symptoms.

[0003] The current mainstream measurement method of esophageal mucosal impedance: 1. Esophageal pH impedance monitoring: monitor the impedance of the esophagus while monitoring pH. Generally, the data needs to be analyzed 24-48 hours after the test. The impedance of the esophageal mucosa cannot be observed immediately. The presence of liquid in the esophageal cavity and the contractility of the esophagus may lead to insufficient contact between the catheter and the esophageal mucosa, thus causing variability in the test results.

[0004] 2. Esophageal pressure and impedance technology: During the process of esophageal manometry, esophageal impedance detection is also taken into account. However, during the process of esophageal manometry, food needs to be swallowed frequently, so the detected esophageal mucosal impedance value is not accurate.

[0005] 3. Real-time esophageal mucosal impedance inspection technology: The catheter contains a balloon that can be expanded to 2 cm in diameter and has 10 impedance sensors with N rows and a spacing of 1 cm. With the support of an endoscope, the catheter can be placed orally in the middle and distal end of the esophagus, about 2 cm above the lower esophageal sphincter, and the balloon is inflated so that the impedance sensor can be attached to the inner wall of the esophageal mucosa. The impedance value of the esophageal mucosa can be measured in real time and fed back to an external device to record and save the data. Disadvantages: The original technology requires endoscopic support to be intubated and the catheter position can be located under visual endoscopy; many patients who are intolerant to endoscopy need to be anesthetized to perform the operation, which increases the difficulty of the doctor's operation and the risk of patient examination; and the endoscopic examination requires a skilled doctor to complete. In addition, there is no pressure measurement data in the endoscopic examination, and it is impossible to accurately grasp the overall pressure situation at the gastroesophageal junction and whether there are physiological lesions such as micro-hernias, which is very important for the diagnosis of gastroesophageal reflux disease.

[0006] Therefore, further improvements are made to the above problems. Summary of the invention

[0007] The main purpose of the present invention is to provide a non-endoscopically mediated locatable and instant esophageal mucosal impedance detection system, which is linked through a catheter component, a real-time mucosal impedance detection module, a real-time pressure monitoring module, a real-time pH monitoring module, a signal processing module, and a high-resolution signal display module. It does not require endoscope mediation or anesthesia, and can instantly detect the esophageal mucosal impedance value and the esophageal pH value, providing a basis for diagnosing gastroesophageal reflux disease.

[0008] To achieve the above objectives, the present invention provides a non-endoscopically mediated locatable instant esophageal mucosal impedance detection system, comprising a catheter assembly and a real-time mucosal impedance detection module, a real-time pressure monitoring module, a real-time pH monitoring module, a signal processing module, and a high-resolution signal display module (i.e., a computer display system) installed on the catheter assembly, wherein: The catheter assembly is inserted into the esophagus through the nasal cavity and during the insertion process, the real-time pressure monitoring module and the real-time pH monitoring module are used to determine whether the catheter assembly is inserted into a preset position, wherein: The real-time pressure monitoring module monitors the pressure data of the position in real time during the movement, and transmits the pressure data to the signal processing module in real time, so that the signal processing module compares and analyzes the pressure data, so that the real-time pressure monitoring module can maintain its position when it moves to the connection between the stomach and the esophagus (i.e., the lower esophageal sphincter); at this time, the signal processing module transmits the pressure data received at the positioning position to the high-resolution signal display module, thereby converting it into a high-resolution pressure measurement image to observe the position of the lower esophageal sphincter and determine whether the lower esophageal sphincter is normal (observe whether the lower esophageal sphincter is more relaxed than that of normal people, and observe whether there is a tiny esophageal hiatal hernia at this location); The real-time pH monitoring module includes a first detection point (pH1, antimony electrode) and a second detection point (pH2, antimony electrode), the first detection point and the second detection point are respectively located on both sides of the real-time pressure monitoring module, after the real-time pressure monitoring module is positioned, according to the preset installation position, the first detection point is located in the stomach and the second detection point is located at the upper edge of the lower esophageal sphincter (preferably 3 cm), the first detection point and the second detection point respectively transmit the first pH data and the second pH data obtained by the detection to the signal processing module, the signal processing module determines whether the catheter assembly is bent in the esophagus according to the first pH data, so as to ensure that the catheter assembly is inserted into the preset position (to ensure that the intubation is completed for subsequent accurate detection), and the signal processing module determines whether the pH value of the esophagus (mucosa) is normal according to the second pH data; The real-time mucosal impedance detection module is provided with a balloon (with a diameter that can be expanded to 2 cm) that is sleeved on the catheter assembly, and a number of impedance sensors (12 impedance sensors in 2 rows with a spacing of 1 cm) are provided on the balloon wall. After the catheter assembly is inserted into the preset position, the balloon is inflated through the inflation hole so that the impedance sensor located on the balloon wall is in close contact with the inner wall of the esophagus, thereby completing the measurement and recording of the esophageal mucosal impedance data.

[0009] As a further preferred technical solution of the above technical solution, the real-time pressure monitoring module is provided with a plurality of strain gauge pressure sensor groups, m pressure sensors in each strain gauge pressure sensor group are adjacent to each other by a first preset distance in a first direction of the catheter assembly, and two adjacent strain gauge pressure sensor groups are arranged in a spiral around the catheter assembly at an interval of 90 degrees, and the real-time pressure monitoring module is kept in position when it moves to the connection between the stomach and the esophagus. Specifically implemented as follows: The resting pressure in the stomach is ≤ammHg, the resting pressure of the lower esophageal sphincter is between a+bmmHg and a+cmmHg, the resting pressure of the esophageal body is ≤dmmHg, and the length range of the lower esophageal sphincter is ecm; The catheter assembly is inserted through the nasal cavity to ncm (catheter scale at the nasal cavity). At this time, the first detection point, the pressure sensor and the second detection point are all located in the stomach. Then the catheter assembly is moved outward. As the catheter assembly moves, some pressure sensors gradually move from the stomach, lower esophageal sphincter and esophagus. The signal processing module monitors the pressure data of the m channels formed by the positions of the m pressure sensors from the proximal end of the catheter pressure to the distal end of the catheter pressure in real time. , t is the sampling time, m is the sampling pressure channel, and the pressure data of m channels are processed by wavelet transform and used The function performs peak detection, parameter f is the peak amplitude range, k is the amplitude width range, j is the minimum distance between the two peaks, and the peak position is the pressure center of the lower esophageal sphincter. The descending inflection points on both sides of the peak are the positions of the stomach and esophagus, respectively. is the peak position; It is the location of the junction of the lower esophageal sphincter and the esophagus; It is the location where the lower esophageal sphincter connects to the stomach; To obtain the maximum number of pressure channels, To obtain the minimum number of channels for pressure; High-resolution pressure measurement images are used to observe the position of the lower esophageal sphincter and determine whether the lower esophageal sphincter is normal. The specific implementation is as follows: the high-resolution signal display module obtains the pressure data through The mapping function is converted into The three color values ​​are displayed in the form of color pixels, defining the pressure from 0 to 150 mmHg in sequence. The colors converted by the mapping function are dark blue, blue, green, yellow-green, yellow, red, and dark red. , where pColor is the additive color function, x is the input current pressure value, L is the length of the color card function, Pmin is the color card minimum pressure value, and Pmax is the color card maximum pressure value. As a further preferred technical solution of the above technical solution, the real-time pH monitoring module also includes a reference electrode (as a reference for the electrode potential), and the reference electrode is located at the insertion end of the catheter assembly, that is, at the end of the first detection point away from the real-time pressure monitoring module.

[0010] As a further preferred technical solution of the above technical solution, for impedance measurement of the impedance sensor, adjacent impedance sensors will form an electrical loop when material passes through the esophagus to monitor the flow of material, and based on the impedance characteristics and changes of the electrical loop, the nature of the reflux material and the distinction between reflux and swallowing can be identified.

[0011] As a further preferred technical solution of the above technical solution, the impedance array data on the balloon are respectively formed into a three-dimensional column stereogram through three-dimensional modeling, and the mucosal impedance value obtained is obtained by The mapping function is converted into The three-color value is then rotated in different directions to view the damaged state of the mucosa at the corresponding esophageal position. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 It is a structural schematic diagram of the present invention.

[0013] Figure 2 It is a schematic diagram of the installation structure of the present invention.

[0014] Figure 3 is a schematic diagram of the insertion of the catheter assembly.

[0015] Figure 4 This is a schematic diagram of high-resolution manometry positioning at the gastroesophageal junction.

[0016] Figure 5 This is a schematic diagram of high-resolution esophageal manometry positioning for hiatal hernia.

[0017] Figure 6 It is a schematic diagram of multi-channel impedance detection to identify reflux events and swallowing events.

[0018] Figure 7 It is a diagram showing the state of mucosal damage. DETAILED DESCRIPTION

[0019] The following description is used to disclose the present invention so that those skilled in the art can implement the present invention. The preferred embodiments described below are only examples, and those skilled in the art can think of other obvious variations. The basic principles of the present invention defined in the following description can be applied to other embodiments, variations, improvements, equivalents, and other technical solutions that do not deviate from the spirit and scope of the present invention.

[0020] In the preferred embodiment of the present invention, those skilled in the art should note that the esophagus and stomach involved in the present invention can be regarded as prior art.

[0021] Preferred embodiments.

[0022] like Figure 1-Figure 7 As shown, the present invention discloses a non-endoscopically mediated locatable instant esophageal mucosal impedance detection system, comprising a catheter assembly and a real-time mucosal impedance detection module, a real-time pressure monitoring module, a real-time pH monitoring module, a signal processing module, and a high-resolution signal display module (i.e., a computer display system) installed on the catheter assembly, wherein: The catheter assembly is inserted into the esophagus through the nasal cavity and during the insertion process, the real-time pressure monitoring module and the real-time pH monitoring module are used to determine whether the catheter assembly is inserted into a preset position, wherein: The real-time pressure monitoring module monitors the pressure data of the position in real time during the movement, and transmits the pressure data to the signal processing module in real time, so that the signal processing module compares and analyzes the pressure data, so that the real-time pressure monitoring module can maintain its position when it moves to the connection between the stomach and the esophagus (i.e., the lower esophageal sphincter); at this time, the signal processing module transmits the pressure data received at the positioning position to the high-resolution signal display module, so as to convert it into a high-resolution pressure measurement image to observe the position of the lower esophageal sphincter and determine whether the lower esophageal sphincter is normal; The real-time pH monitoring module includes a first detection point (pH1, antimony electrode) and a second detection point (pH2, antimony electrode), the first detection point and the second detection point are respectively located on both sides of the real-time pressure monitoring module. After the real-time pressure monitoring module is positioned, according to the preset installation position, the first detection point is located in the stomach and the second detection point is located at the upper edge of the lower esophageal sphincter (preferably 3 cm), the first detection point and the second detection point transmit the first pH data and the second pH data obtained by the detection to the signal processing module respectively, and the signal The signal processing module determines whether the catheter assembly is bent in the esophagus according to the first pH data, so as to ensure that the catheter assembly is inserted into the preset position (when inserted into the stomach, the value of the first pH data will drop below 3; and the pressure channel of the high-resolution esophageal pressure measurement can identify the position of the LES. If it is folded, the esophageal pressure map seen is also a folded map, ensuring that the intubation is completed for subsequent accurate detection), and the signal processing module determines whether the pH value of the esophagus (mucosa) is normal according to the second pH data (according to the "Clinical Operation Guidelines for Esophageal Dynamic Reflux Monitoring (Adults)", acid reflux is defined as the pH value of the distal esophagus dropping to <4. If the second pH data shows a value greater than 4, it can be preliminarily determined that no acid reflux occurred in the esophagus during the test); The real-time mucosal impedance detection module is provided with a balloon (with a diameter that can be expanded to 2 cm) that is sleeved on the catheter assembly, and a number of impedance sensors (12 impedance sensors in 2 rows with a spacing of 1 cm) are provided on the balloon wall. After the catheter assembly is inserted into the preset position, the balloon is inflated through the inflation hole so that the impedance sensor located on the balloon wall is in close contact with the inner wall of the esophagus, thereby completing the measurement and recording of the esophageal mucosal impedance data.

[0023] Specifically, the real-time pressure monitoring module is provided with a plurality of strain gauge pressure sensor groups (preferably 6 groups), and m pressure sensors in each strain gauge pressure sensor group are adjacent to each other by a first preset distance (preferably 1 cm) in a first direction of the catheter assembly (i.e., the insertion movement direction of the catheter assembly), and two adjacent strain gauge pressure sensor groups are arranged in a spiral around the catheter assembly at an interval of 90 degrees, and the real-time pressure monitoring module is kept in position when it moves to the connection between the stomach and the esophagus. Specifically implemented as follows: The resting pressure in the stomach is ≤ammHg (according to the clinical typical value a=10), the resting pressure of the lower esophageal sphincter is between a+bmmHg and a+cmmHg (according to the clinical typical value, b=13, c=43), the resting pressure of the esophageal body is ≤dmmHg (according to the clinical typical value, d=8), and the length range of the lower esophageal sphincter is ecm (according to the clinical typical value, e=2.4~4.8); the catheter assembly is inserted through the nasal cavity to ncm (catheter scale at the nasal cavity), at which time the first detection point, the pressure sensor and the second detection point are all located in the stomach, and then the catheter assembly is moved outward. As the catheter assembly moves, some pressure sensors gradually move from the stomach, the lower esophageal sphincter and the esophagus. The signal processing module monitors the pressure data of the m channels formed by the positions of the m pressure sensors from the proximal end of the catheter pressure to the distal end of the catheter pressure in real time. , t is the sampling time, m is the sampling pressure channel, and the pressure data of m channels are processed by wavelet transform and used The function performs peak detection (identifying effective respiratory waves), with parameters f (mmHg) as the peak amplitude range, k (cm) as the amplitude width range, and j (cm) as the minimum distance between the two peaks. At the same time, the system obtains that pH1 should be less than 3.0 and pH2 should be greater than 4.0, and the peak position is the pressure center of the lower esophageal sphincter. The descending inflection points on both sides of the peak are the positions of the stomach and esophagus, respectively, where: is the peak position; It is the location of the junction of the lower esophageal sphincter and the esophagus; It is the location where the lower esophageal sphincter connects to the stomach; To obtain the maximum number of pressure channels, To obtain the minimum number of channels for pressure; High-resolution manometry images are used to observe the position of the lower esophageal sphincter and determine whether the lower esophageal sphincter is normal. The specific implementation is as follows: (The lower esophageal sphincter is a physiological high-pressure area formed by smooth muscle. Under normal circumstances, the lower esophageal sphincter (LES) is in a closed state and relaxes during the process of swallowing food. When the pressure sensor on the catheter assembly moves to the high-pressure area of ​​the lower esophageal sphincter, the pressure sensor senses the high pressure at the gastroesophageal junction, feeds back to the signal processor, and amplifies the signal. Under high-resolution esophageal manometry images, the precise position of the lower esophageal sphincter can be clearly identified, such as Figure 4 As shown in the figure): The high-resolution signal display module will obtain the pressure data through The mapping function is converted into Tristimulus values ​​( , is the color value, x is the current pressure value), so it is displayed in the form of color pixels, and the pressure is defined from 0 to 150 mmHg in sequence. The mapping function is converted into colors in the order of dark blue (RGBmin color value), blue, green, yellow-green, yellow, red, and dark red (RGBmax color value) (usually LES position pressure is green, while the stomach and esophagus are blue). , where pColor is the additive function, x is the input current pressure value, L is the length of the color card function, Pmin is the minimum pressure value of the color card (used to correspond to the RGBmin color value), and Pmax is the maximum pressure value of the color card (used to correspond to the RGBmax color value). Observe whether the lower esophageal sphincter is more relaxed than that of normal people, and observe whether there is a tiny hiatal hernia there. High-resolution esophageal manometry can accurately locate the gastroesophageal junction and clearly display the positional relationship between the lower esophageal sphincter (LES) and the diaphragm (CD). According to the guidance of the Chicago Classification 3.0, the LES and CD of normal people overlap, and the separation distance is less than 1 cm, which is clinically called EJG-I type. Figure 5 A in the figure; patients with gastroesophageal reflux disease often have a separation between the LES and CD, with a separation distance of 1-2 cm, clinically known as EJG-II type. Figure 5 B in the figure; when the separation distance is greater than 2 cm, it is clinically called EJG-III type. Figure 5 C and Figure 5 D in.

[0024] More specifically, the real-time pH monitoring module also includes a reference electrode (as a reference for the electrode potential), which is located at the insertion end of the catheter assembly, that is, at the end of the first detection point (three centimeters above the reference electrode) away from the real-time pressure monitoring module.

[0025] Furthermore, for impedance measurement of the impedance sensor, adjacent impedance sensors will form an electrical loop when material passes through the esophagus to monitor the flow of material, and distinguish the nature of the refluxed material and distinguish reflux from swallowing based on the impedance characteristics and changes of the electrical loop, such as Figure 6 As shown: Figure 6 As shown in A, the most distal channel (Z6) first showed an impedance value decrease of >50% compared with the baseline impedance value, followed by a decrease in impedance values ​​in Z5 and Z4 channels (as shown in the vertical line area). The impedance value changes were retrograde (as shown by the left and right arrows), indicating that the event was a reflux event. Figure 6 In B, it can be seen that the impedance value of the most proximal channel (Z1) first decreases, and then the impedance value change is transmitted anterogradely to the most distal channel (Z6) (indicated by the arrow), indicating that the event is a swallowing event.

[0026] Furthermore, if Figure 7As shown in the figure, the impedance array data on the balloon are respectively formed into a three-dimensional column stereogram through three-dimensional modeling, and the mucosal impedance value is obtained through The mapping function is converted into The three-color value is then rotated in different directions to view the damaged state of the mucosa at the corresponding esophageal position.

[0027] Detecting pH value through antimony electrode: Antimony electrode is a redox electrode that detects the pH value of the solution by measuring the potential difference between metal antimony and oxide. When the surface of metal antimony comes into contact with the solution being tested, the surface is oxidized to generate Sb2O3. The potential difference between metal antimony and oxide depends on the concentration of Sb2O3, and the concentration of Sb2O3 is related to the concentration of hydrogen ions in the solution. Therefore, the pH value of the esophageal mucosa can be measured by measuring this potential difference.

[0028] The advantages of the present invention are: 1. It is not endoscopically mediated and does not require anesthesia. It can immediately detect the esophageal mucosal impedance and esophageal pH value, providing a basis for the diagnosis of gastroesophageal reflux disease; 2. The gastroesophageal junction can be accurately located by manometry; 3. The real-time pressure at the gastroesophageal junction can be directly determined by manometry to determine whether the lower esophageal sphincter is relaxed and whether there is a hiatal hernia. These are important bases for diagnosing gastroesophageal reflux disease. 4. No pH calibration is required when the catheter is used. The specific implementation is that during the production stage of the catheter, the internal memory chip saves the calibration parameters. Therefore, when the catheter is used, the calibration step can be skipped and the calibration parameters can be directly obtained from the memory chip to calculate the pH value of the sampled solution.

[0029] 5. The intragastric pressure measurement point displays the intragastric pH value in real time to ensure that the intubation tube will not bend in the esophagus, resulting in intubation failure and unsuccessful detection.

[0030] It is worth mentioning that the technical features such as the esophagus and stomach involved in the patent application of this invention should be regarded as the prior art. The specific structure, working principle and possible control method and spatial layout method of these technical features can be selected by conventional methods in the field, and should not be regarded as the inventive point of this patent. This patent will not be further elaborated.

[0031] For those skilled in the art, it is still possible to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A non-endoscopically mediated real-time esophageal mucosal impedance detection system, characterized in that: It includes a catheter assembly and a real-time mucosal impedance detection module, a real-time pressure monitoring module, a real-time pH monitoring module, a signal processing module, and a high-resolution signal display module installed on the catheter assembly, wherein: The catheter assembly is inserted into the esophagus through the nasal cavity and during the insertion process, the real-time pressure monitoring module and the real-time pH monitoring module are used to determine whether the catheter assembly is inserted into a preset position, wherein: The real-time pressure monitoring module monitors the pressure data of the position in real time during the movement, and transmits the pressure data to the signal processing module in real time, so that the signal processing module compares and analyzes the pressure data, so that the real-time pressure monitoring module can maintain its position when it moves to the connection between the stomach and the esophagus; at this time, the signal processing module transmits the pressure data received at the positioning position to the high-resolution signal display module, so as to convert it into a high-resolution pressure measurement image to observe the position of the lower esophageal sphincter and determine whether the lower esophageal sphincter is normal; The real-time pH monitoring module includes a first detection point and a second detection point, the first detection point and the second detection point are respectively located on both sides of the real-time pressure monitoring module, after the real-time pressure monitoring module is positioned, according to the preset installation position, the first detection point is located in the stomach and the second detection point is located at the upper edge of the lower esophageal sphincter, the first detection point and the second detection point respectively transmit the first pH data and the second pH data obtained by the detection to the signal processing module, the signal processing module determines whether the catheter assembly is bent in the esophagus according to the first pH data, so as to ensure that the catheter assembly is inserted into the preset position, and the signal processing module determines whether the pH value of the esophagus is normal according to the second pH data; The real-time mucosal impedance detection module is provided with a balloon which is sleeved on the catheter assembly, and a plurality of impedance sensors are provided on the balloon wall. After the catheter assembly is inserted into a preset position, the balloon is inflated through the inflation hole so that the impedance sensors on the balloon wall are closely attached to the inner wall of the esophagus, thereby completing the measurement and recording of the esophageal mucosal impedance data.

2. The non-endoscopically mediated real-time esophageal mucosal impedance detection system according to claim 1, characterized in that: The real-time pressure monitoring module is provided with a plurality of strain gauge pressure sensor groups, wherein m pressure sensors in each strain gauge pressure sensor group are adjacent to each other by a first preset distance in a first direction of the catheter assembly, and two adjacent strain gauge pressure sensor groups are arranged in a spiral around the catheter assembly at an interval of 90 degrees, and the real-time pressure monitoring module is kept in position when it moves to the connection between the stomach and the esophagus. Specifically implemented as follows: The resting pressure in the stomach is ≤ammHg, the resting pressure of the lower esophageal sphincter is between a+bmmHg and a+cmmHg, the resting pressure of the esophageal body is ≤dmmHg, and the length range of the lower esophageal sphincter is ecm; The catheter assembly is inserted through the nasal cavity to ncm. At this time, the first detection point, the pressure sensor and the second detection point are all located in the stomach. Then the catheter assembly is moved outward. As the catheter assembly moves, some pressure sensors gradually move from the stomach, the lower esophageal sphincter and the esophagus. The signal processing module monitors the pressure data of the m channels formed by the positions of the m pressure sensors from the proximal end of the catheter pressure to the distal end of the catheter pressure in real time. , t is the sampling time, m is the sampling pressure channel, and the pressure data of m channels are processed by wavelet transform and used The function performs peak detection, parameter f is the peak amplitude range, k is the amplitude width range, j is the minimum distance between the two peaks, and the peak position is the pressure center of the lower esophageal sphincter. The descending inflection points on both sides of the peak are the positions of the stomach and esophagus, respectively. is the peak position; The location of the junction of the lower esophageal sphincter and the esophagus; It is the location where the lower esophageal sphincter connects to the stomach; To obtain the maximum number of pressure channels, To obtain the minimum number of channels for pressure; High-resolution pressure measurement images are used to observe the position of the lower esophageal sphincter and determine whether the lower esophageal sphincter is normal. The specific implementation is as follows: the high-resolution signal display module obtains the pressure data through The mapping function is converted into The three color values ​​are displayed in the form of color pixels, defining the pressure from 0 to 150 mmHg in sequence. The colors converted by the mapping function are dark blue, blue, green, yellow-green, yellow, red, and dark red. , where pColor is the additive color function, x is the input current pressure value, L is the length of the color card function, Pmin is the minimum pressure value of the color card, and Pmax is the maximum pressure value of the color card.

3. The non-endoscopically mediated real-time esophageal mucosal impedance detection system according to claim 1, characterized in that: The real-time pH monitoring module further comprises a reference electrode, and the reference electrode is located at the insertion end of the catheter assembly, that is, at the end of the first detection point away from the real-time pressure monitoring module.

4. The non-endoscopically mediated real-time esophageal mucosal impedance detection system according to claim 1, characterized in that: For impedance measurement of impedance sensors, adjacent impedance sensors will form an electrical loop when material passes through the esophagus to monitor the flow of material, and identify the nature of the reflux material and distinguish between reflux and swallowing based on the impedance characteristics and changes of the electrical loop.

5. The non-endoscopically mediated real-time esophageal mucosal impedance detection system according to claim 4, characterized in that: The impedance array data on the balloon are transformed into a three-dimensional column stereogram through three-dimensional modeling, and the mucosal impedance value is obtained through The mapping function is converted into The three-color value is then rotated in different directions to view the damaged state of the mucosa at the corresponding esophageal position.

Images