Equipment for mouse intraperitoneal injection

Abstract

The invention discloses equipment for mouse intraperitoneal injection, and relates to the technical field of medical scientific research, the equipment comprises a pedal control device and an electric injection device, the electric injection device comprises an injector fixing assembly, an injector push-pull assembly and a support control assembly, an injector is fixed on the injector fixing assembly, and the injector push-pull assembly is fixed on the support control assembly. The injector fixing assembly is embedded and clamped at the front end of the injector push-pull assembly, and the injector push-pull assembly is connected to the supporting control assembly in an angle-adjustable mode; the pedal control device is in wireless connection with the supporting control assembly, and the supporting control assembly is electrically connected with the injector push-pull assembly. The pedal control device and the electric injection device are matched to inject chemicals into the mouse, so that the operation safety is high, and the efficiency is high.

Description

Technical Field

[0001] The invention relates to the technical field of medical scientific research, and in particular to a device for intraperitoneal injection of mice. Background Art

[0002] As a conventional route of administration, intraperitoneal injection is suitable for mild water-soluble drugs. Its wide absorption area and direct access to the blood make the drug absorption fast and have strong absorption capacity. The drug's circulation path enters the portal vein through the superior mesenteric vein, then passes through the liver, and then enters the inferior vena cava through the hepatic vein, and finally flows into the right atrium and right ventricle, where it is absorbed into the blood circulation. This method avoids the first-pass metabolism of the gastrointestinal tract, but the first-pass metabolism of the liver still exists. Despite this, its bioavailability is still very high, so it is widely used.

[0003] During the specific operation, you should first gently grasp the animal's tail with one hand and then place it on a rough surface. Then, use the thumb and index finger of the other hand to firmly clamp the animal's ears and the skin between them, and use the middle finger and ring finger to press the skin on the back of the animal against the palm to ensure stability. The best needle insertion position is the midline of the lower abdomen, because there are no abdominal muscles and less blood circulation there, reducing the risk of bleeding. Intraperitoneal injections are generally inserted at an angle of 30-60°, and the operation is slow to prevent rapid puncture of the intestine. Before injecting the drug, it is often necessary to withdraw the needle plug, make sure that the needle has not pierced the small intestine, bladder or blood vessels, and then slowly inject the drug solution.

[0004] Traditional intraperitoneal injections usually require the non-dominant hand to hold the mouse and the dominant hand to inject, which poses a safety hazard for novice researchers. In addition, the hands will repeatedly switch between the mouse and the syringe, which is time-consuming and inefficient. Therefore, developing an efficient and safe intraperitoneal injection device is a more urgent goal. Summary of the invention

[0005] The purpose of the present invention is to provide a device for intraperitoneal injection of mice, so as to solve the problems that the injection method of catching mice with the non-dominant hand and injecting with the dominant hand has high safety risks, low efficiency and is unfriendly to scientific research novices.

[0006] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0007] The present invention provides a device for intraperitoneal injection of mice, comprising a foot control device and an electric injection device, wherein the electric injection device comprises a syringe fixing component, a syringe push-pull component and a support control component, wherein the syringe is fixed on the syringe fixing component, the syringe fixing component is embedded and clamped at the front end of the syringe push-pull component, and the syringe push-pull component is connected to the support control component in an angle-adjustable manner; the foot control device and the support control component are wirelessly connected, and the support control component and the syringe push-pull component are electrically connected.

[0008] Preferably, the pedal control device comprises a first bottom plate, on which two connecting rods are symmetrically arranged, a rotating shaft is installed between opposite surfaces of the two connecting rods, and a pedal is rotatably connected to the rotating shaft;

[0009] A first controller and a first button are also installed on the first bottom plate, the first controller is located in front of the foot pedal, the first controller and the first button are electrically connected, and the first controller and the support control assembly are electrically connected;

[0010] There are two first buttons, which are respectively located directly below the front and rear ends of the foot pedal;

[0011] The foot control device also includes a spring, one end of which is hung on the foot pedal, and the other end of which is hung on the first bottom plate. Two springs are provided and are respectively located at the front and rear ends of the foot pedal.

[0012] Preferably, the syringe fixing assembly includes a fixing block, the top of which is provided with an arc-shaped opening for placing the syringe, the fixing block is also provided with an arc-shaped cover, one end of the arc-shaped cover is hinged on the fixing block, and the other end is snap-connected to the fixing block, the fixing block is also provided with an ear groove, and the ear seat at the tail end of the syringe barrel of the syringe is inserted into the ear groove; the side wall and the bottom of the fixing block are both installed with a limiting plate, and the syringe fixing assembly is snap-connected to the front end of the syringe push-pull assembly through the limiting plate.

[0013] Preferably, the syringe push-pull assembly comprises a push-pull seat and a motor fixing seat connected together;

[0014] The cross section of the push-pull seat is concave-shaped, a fixing groove is provided at the front end of the push-pull seat, the limit plate is inserted into the fixing groove, a lead screw support plate is installed at the inner center of the push-pull seat, a lead screw is rotatably connected to the lead screw support plate, a plurality of slide grooves are provided inside the rear end of the push-pull seat, a push-pull plate is also provided in the push-pull seat, the push-pull plate is slidably connected in the slide groove, and the lead screw and the push-pull plate are transmission-connected;

[0015] A motor is installed in the motor fixing seat, and the output end of the motor is drivingly connected to the lead screw; the motor is electrically connected to the support control component;

[0016] A plurality of first plug rods are provided on the side wall of the motor fixing seat, and a plurality of first plug holes are provided on the side wall of the push-pull seat, the first plug rods are inserted into the first plug holes, threaded holes are provided on the side walls of the push-pull seat and the motor fixing seat, and the threaded holes are covered with a clamping plate, and the clamping plate is provided with a threaded hole, and the screws are connected to the threaded holes on the side wall of the push-pull seat or the motor fixing seat after passing through the threaded holes on the clamping plate.

[0017] Preferably, the push-pull plate and the plunger handle of the syringe are abutted together, and a pressure strip is rotatably connected to the push-pull plate, and the pressure strip is pressed onto the plunger handle of the syringe.

[0018] Preferably, the bottom end of the push-pull seat is connected to an angle adjustment block, the angle adjustment block is provided with a first through hole, and a plurality of second insertion rods are evenly distributed around the first through hole in a circumferential manner;

[0019] The support control assembly includes a second base plate, a support rod is installed on the second base plate, a second through hole is opened on the top of the support rod, a plurality of second plug holes are evenly distributed around the second through hole in a circular shape, the first through hole matches the second through hole, and the second plug rod is inserted into the second plug hole; the support rod and the angle adjustment block are connected by rivets or bolts.

[0020] Preferably, a second controller is also installed on the second base plate, the first controller and the second controller are wirelessly connected, and the second controller and the motor are electrically connected.

[0021] Preferably, a second button is also installed on the second base plate, and the second button is electrically connected to the second controller.

[0022] Compared with the prior art, the beneficial technical effects of the present invention are:

[0023] The present invention provides a device for intraperitoneal injection of mice. When in use, an operator can use his dominant hand to grab the mouse and place it at the front end of an electric injection device, and control the electric injection device by stepping on a foot control device to complete the injection operation of the mouse, thereby solving the problem that the injection method of using the non-dominant hand to grab the mouse and the dominant hand to inject has high safety risks, low efficiency and is unfriendly to scientific research novices. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The present invention will be further described below in conjunction with the accompanying drawings.

[0025] Figure 1 This is a schematic diagram of the structure of a device for intraperitoneal injection in mice according to the present invention;

[0026] Figure 2It is a schematic diagram of the structure of the foot control device of the present invention;

[0027] Figure 3 It is a front view of the foot control device of the present invention;

[0028] Figure 4 The electric injection device of the present invention is schematically shown in FIG. Figure 1 ;

[0029] Figure 5 This is a schematic diagram of the structure of the support control component of the present invention;

[0030] Figure 6 This is a schematic diagram of the structure of the syringe fixing assembly of the present invention;

[0031] Figure 7 The electric injection device of the present invention is schematically shown in FIG. Figure 2 ;

[0032] Figure 8 A top view of the electric injection device of the present invention;

[0033] Fig. 9 This is a schematic diagram of the push-pull seat structure of the present invention;

[0034] Fig.10 This is a schematic diagram of the structure of the motor fixing seat of the present invention;

[0035] Fig.11 It is a schematic diagram of the push-pull plate structure of the present invention.

[0036] Description of reference numerals: 1. foot control device; 2. electric injection device; 3. syringe fixing assembly; 4. syringe push-pull assembly; 5. support control assembly;

[0037] 11. first base plate; 12. connecting rod; 13. foot pedal; 14. first controller; 15. first button; 16. spring;

[0038] 31. Fixed block; 32. Arc cover; 33. Ear groove; 34. Limiting plate;

[0039] 41. Push-pull seat; 42. Motor fixing seat; 43. Clamp;

[0040] 411, fixed groove; 412, screw support plate; 413, screw; 414, slide groove; 415, push-pull plate; 416, angle adjustment block;

[0041] 421, motor; 4151, press strip;

[0042] 51. Second base plate; 52. Support rod; 53. Second controller; 54. Second button. DETAILED DESCRIPTION

[0043] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0044] like Figure 1-11 As shown, a device for intraperitoneal injection of mice includes a foot control device 1 and an electric injection device 2, wherein the electric injection device 2 includes a syringe fixing component 3, a syringe push-pull component 4 and a support control component 5, the syringe is fixed on the syringe fixing component 3, the syringe fixing component 3 is embedded and clamped at the front end of the syringe push-pull component 4, and the syringe push-pull component 4 is connected to the support control component 5 with an adjustable angle; the foot control device 1 and the support control component 5 are wirelessly connected, and the support control component 5 and the syringe push-pull component 4 are electrically connected.

[0045] Specifically, the pedal control device 1 comprises a first base plate 11, on which two connecting rods 12 are symmetrically arranged, a rotating shaft is installed between opposite surfaces of the two connecting rods 12, and a pedal 13 is rotatably connected to the rotating shaft;

[0046] A first controller 14 and a first button 15 are also installed on the first base plate 11. The first controller 14 is located in front of the foot pedal 13. The first controller 14 and the first button 15 are electrically connected. The first controller 14 and the support control assembly 5 are electrically connected.

[0047] The first buttons 15 are provided with two and are respectively located directly below the front and rear ends of the foot pedal 13;

[0048] The foot control device 1 further includes a spring 16 , one end of which is connected to the foot pedal 13 , and the other end of which is connected to the first base plate 11 . Two springs 16 are provided and are located at the front and rear ends of the foot pedal 13 , respectively.

[0049] Specifically, the syringe fixing assembly 3 includes a fixing block 31, the top of which is provided with an arc-shaped opening for placing the syringe, and the fixing block 31 is also provided with an arc-shaped cover 32, one end of the arc-shaped cover 32 is hinged on the fixing block 31, and the other end is snap-connected to the fixing block 31, and the fixing block 31 is also provided with an ear groove 33, and the ear seat at the tail end of the syringe barrel of the syringe is inserted into the ear groove 33; the side wall and the bottom of the fixing block 31 are both installed with a limiting plate 34, and the syringe fixing assembly 3 is snap-connected to the front end of the syringe push-pull assembly 4 through the limiting plate 34.

[0050] The fixing block 31 in the syringe fixing assembly 3 is provided with various models to target different types of syringes.

[0051] Specifically, the syringe push-pull assembly 4 includes a push-pull seat 41 and a motor fixing seat 42 connected together;

[0052] The cross section of the push-pull seat 41 is concave-shaped, a fixing groove 411 is provided at the front end of the push-pull seat 41, the limit plate 34 is inserted into the fixing groove 411, a lead screw support plate 412 is installed at the inner center of the push-pull seat 41, a lead screw 413 is rotatably connected to the lead screw support plate 412, a plurality of slide grooves 414 are provided inside the rear end of the push-pull seat 41, a push-pull plate 415 is also provided in the push-pull seat 41, the push-pull plate 415 is slidably connected in the slide groove 414, and the lead screw 413 and the push-pull plate 415 are transmission-connected;

[0053] A motor 421 is installed in the motor fixing seat 42, and the output end of the motor 421 is in transmission connection with the lead screw 413; the motor 421 is electrically connected to the support control assembly 5;

[0054] The side wall of the motor fixing seat 42 is provided with a plurality of first plug rods, and the side wall of the push-pull seat 41 is provided with a plurality of first plug holes, the first plug rods are inserted into the first plug holes, the side walls of the push-pull seat 41 and the motor fixing seat 42 are provided with threaded holes, and the threaded holes are covered with a clamping plate 43, and the clamping plate 43 is provided with threaded holes. The screws pass through the threaded holes on the clamping plate 43 and are connected to the threaded holes on the side walls of the push-pull seat 41 or the motor fixing seat 42.

[0055] Specifically, the push-pull plate 415 and the plunger handle of the syringe are abutted together, and a pressure strip 4151 is rotatably connected to the push-pull plate 415 , and the pressure strip 4151 is pressed onto the plunger handle of the syringe.

[0056] Specifically, the bottom end of the push-pull seat 41 is connected to an angle adjustment block 416, and a first through hole is formed on the angle adjustment block 416, and a plurality of second insertion rods are evenly distributed around the first through hole in a circumferential manner;

[0057] The support control assembly 5 includes a second base plate 51, on which a support rod 52 is installed. A second through hole is opened at the top end of the support rod 52, and a plurality of second plug holes are evenly distributed around the second through hole in a circular shape. The first through hole matches the second through hole, and the second plug rod is inserted into the second plug hole; the support rod 52 and the angle adjustment block 416 are connected by rivets or bolts.

[0058] Specifically, a second controller 53 is further installed on the second base plate 51 , the first controller 14 and the second controller 53 are wirelessly connected, and the second controller 53 and the motor 421 are electrically connected.

[0059] Specifically, a second button 54 is also installed on the second bottom plate 51 , and the second button is electrically connected to the second controller 53 .

[0060] The use process of the present invention is as follows:

[0061] In the first step, the syringe containing the medicine is placed on the syringe fixing assembly 3 and covered with the arc-shaped cover 32 . The ear seat of the syringe barrel is inserted into the ear groove 33 .

[0062] In the second step, the syringe fixing assembly 3 is clamped on the syringe push-pull assembly 4.

[0063] The third step is to adjust the angle of the syringe push-pull assembly 4 and install it on the support control assembly 5. To facilitate the subsequent adjustment of the injection angle of the syringe push-pull assembly 4, it is recommended to use a bolt and nut connection method to install the syringe push-pull assembly 4 on the support control assembly 5.

[0064] Step 4, injection operation: the operator uses his dominant hand to grab the mouse and place it on the front end of the syringe, then steps on the foot pedal 13 so that the foot pedal 13 presses the first button 15 at the front end, and the first controller 14 sends a wireless message to the second controller 53 after receiving the information that the first button 15 is pressed, and the second controller 53 controls the motor 421 to rotate forward after receiving the signal, and the motor 421 drives the lead screw 413 to rotate forward when rotating forward, and the lead screw 413 drives the push-pull plate 415 to move forward along the slide groove 414 when rotating forward, and the push-pull plate 415 abuts against the plunger handle of the syringe during the forward movement and drives the plunger handle of the syringe to move forward synchronously, thereby completing the drug injection operation.

[0065] Step 5: Absorption operation: In the first step, replace the syringe containing the medicine with an empty syringe. After that, complete the second and third steps in sequence, skip the fourth step, and implement the fifth step:

[0066] The foot pedal 13 is stepped on to press the first button 15 at the front end. After receiving the information that the first button 15 is pressed, the first controller 14 sends wireless information to the second controller 53. After receiving the signal, the second controller 53 controls the motor 421 to rotate forward. When the motor 421 rotates forward, it drives the lead screw 413 to rotate forward. When the lead screw 413 rotates forward, it drives the push-pull plate 415 to move forward along the slide groove 414. During the forward movement of the push-pull plate 415, it abuts against the plunger handle of the syringe. At this time, the pressure bar 4151 is rotated to press the pressure bar 4151 against the plunger handle of the syringe.

[0067] Afterwards, the operator uses his dominant hand to grab the mouse and place it at the front end of the syringe, and steps on the foot pedal 13 so that the foot pedal 13 presses the first button 15 at the rear end. After receiving the information that the first button 15 is pressed, the first controller 14 sends a wireless message to the second controller 53. After receiving the signal, the second controller 53 controls the motor 421 to reverse. When the motor 421 reverses, it drives the lead screw 413 to reverse. When the lead screw 413 reverses, it drives the push-pull plate 415 to move backward along the slide groove 414. The push-pull plate 415 drives the plunger handle of the syringe to move backward synchronously to complete the tissue sample absorption operation.

[0068] During or before the injection and aspiration operations, the operator presses the second button 54 with the non-dominant hand. After receiving the signal from the second button 54 , the second controller 53 adjusts the speed of the motor 421 .

[0069] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0070] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A device for intraperitoneal injection of mice, characterized in that: The invention comprises a foot control device (1) and an electric injection device (2), wherein the electric injection device (2) comprises a syringe fixing component (3), a syringe push-pull component (4) and a support control component (5), wherein the syringe is fixed on the syringe fixing component (3), the syringe fixing component (3) is embedded and clamped at the front end of the syringe push-pull component (4), and the syringe push-pull component (4) is connected to the support control component (5) in an angle-adjustable manner; the foot control device (1) and the support control component (5) are wirelessly connected, and the support control component (5) and the syringe push-pull component (4) are electrically connected.

2. The device for intraperitoneal injection of mice according to claim 1, characterized in that: The pedal control device (1) comprises a first base plate (11), on which two connecting rods (12) are symmetrically arranged, a rotating shaft is installed between opposite surfaces of the two connecting rods (12), and a pedal (13) is rotatably connected to the rotating shaft; A first controller (14) and a first button (15) are also mounted on the first base plate (11); the first controller (14) is located in front of the foot pedal (13); the first controller (14) and the first button (15) are electrically connected; and the first controller (14) and the support control assembly (5) are electrically connected; Two first buttons (15) are provided and are respectively located directly below the front and rear ends of the foot pedal (13); The foot control device (1) further comprises a spring (16), one end of the spring (16) being hung on the foot pedal (13), and the other end being hung on the first base plate (11), and two springs (16) are provided and are respectively located at the front and rear ends of the foot pedal (13).

3. The device for intraperitoneal injection of mice according to claim 2, characterized in that: The syringe fixing assembly (3) comprises a fixing block (31), the top of which is provided with an arc-shaped opening for placing the syringe, the fixing block (31) is also provided with an arc-shaped cover (32), one end of the arc-shaped cover (32) is hinged on the fixing block (31), and the other end is snap-connected to the fixing block (31), the fixing block (31) is also provided with an ear groove (33), and the ear seat at the rear end of the syringe barrel of the syringe is inserted into the ear groove (33); the side wall and the bottom of the fixing block (31) are both provided with a limiting plate (34), and the syringe fixing assembly (3) is snap-connected to the front end of the syringe push-pull assembly (4) through the limiting plate (34).

4. The device for intraperitoneal injection of mice according to claim 3, characterized in that: The syringe push-pull assembly (4) comprises a push-pull seat (41) and a motor fixing seat (42) connected together; The cross section of the push-pull seat (41) is concave in shape, a fixing groove (411) is provided at the front end of the push-pull seat (41), the limit plate (34) is inserted into the fixing groove (411), a lead screw support plate (412) is installed at the inner center of the push-pull seat (41), a lead screw (413) is rotatably connected to the lead screw support plate (412), a plurality of slide grooves (414) are provided inside the rear end of the push-pull seat (41), a push-pull plate (415) is also provided in the push-pull seat (41), the push-pull plate (415) is slidably connected in the slide groove (414), and the lead screw (413) and the push-pull plate (415) are transmission-connected; A motor (421) is installed in the motor fixing seat (42), and the output end of the motor (421) is drivingly connected to the lead screw (413); the motor (421) is electrically connected to the support control component (5); A plurality of first plug rods are provided on the side wall of the motor fixing seat (42), and a plurality of first plug holes are provided on the side wall of the push-pull seat (41), wherein the first plug rods are plugged into the first plug holes. Threaded holes are provided on the side walls of the push-pull seat (41) and the motor fixing seat (42), and the threaded holes are covered with a clamping plate (43), and a threaded hole is provided on the clamping plate (43). After passing through the threaded hole on the clamping plate (43), the screw is connected to the threaded hole on the side wall of the push-pull seat (41) or the motor fixing seat (42).

5. The device for intraperitoneal injection of mice according to claim 4, characterized in that: The push-pull plate (415) and the plunger handle of the syringe are in contact with each other. A pressure strip (4151) is rotatably connected to the push-pull plate (415), and the pressure strip (4151) is pressed against the plunger handle of the syringe.

6. The device for intraperitoneal injection of mice according to claim 4, characterized in that: The bottom end of the push-pull seat (41) is connected to an angle adjustment block (416), and a first through hole is formed on the angle adjustment block (416), and a plurality of second insertion rods are evenly distributed around the first through hole in a circular shape; The support control assembly (5) comprises a second base plate (51), a support rod (52) is mounted on the second base plate (51), a second through hole is formed at the top end of the support rod (52), a plurality of second plug holes are evenly distributed around the second through hole, the first through hole matches the second through hole, and the second plug rod is plugged into the second plug hole; the support rod (52) and the angle adjustment block (416) are connected by rivets or bolts.

7. The device for intraperitoneal injection of mice according to claim 6, characterized in that: A second controller (53) is also installed on the second base plate (51); the first controller (14) and the second controller (53) are wirelessly connected, and the second controller (53) and the motor (421) are electrically connected.

8. The device for intraperitoneal injection of mice according to claim 7, characterized in that: A second button (54) is also mounted on the second bottom plate (51), and the second button is electrically connected to the second controller (53).

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