Sevoflurane injection hydrogel with both ph response and enzyme response and preparation process of sevoflurane injection hydrogel

Abstract

The invention discloses sevoflurane injection hydrogel with both ph and enzyme response and a preparation process thereof, relates to the field of sevoflurane injection hydrogel, and solves the problems that the existing medicine for treating myocardial injury has a certain onset period and cannot well perform rapid treatment and environment. The sevoflurane-based hydrogel comprises the following raw materials: sevoflurane, a biocompatible polymer, a cross-linking agent and a responsive component. The hydrogel can effectively improve the reaction time efficiency and the acting effect on myocardial injury, so that the use effect is greatly improved.

Description

Technical Field

[0001] The invention relates to the field of sevoflurane injection hydrogel, and in particular to a sevoflurane injection hydrogel having both pH and enzyme responses and a preparation process thereof. Background Art

[0002] Myocardial damage refers to damage to myocardial cells or myocardial fibroblasts caused by various reasons. There are many causes of myocardial damage, the most common of which include viral myocarditis, myocardial infarction, primary cardiomyopathy, alcoholic cardiomyopathy, coronary heart disease, myocardial ischemia, etc.

[0003] Since the myocardium is responsible for the normal operation of the human heart, the prior art usually focuses on developing specific drugs to effectively treat myocardial damage in a timely manner and reduce the mortality rate of patients with myocardial infarction. Therefore, a sevoflurane injection hydrogel with both pH and enzyme response and a preparation process thereof are proposed. Summary of the invention

[0004] The purpose of the present invention is to provide a sevoflurane injection hydrogel with both pH and enzyme responses and a preparation process thereof, which solves the problem that existing drugs for myocardial injury have a certain onset period and cannot be used for rapid treatment and environmental protection.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solution: a sevoflurane injection hydrogel with both pH and enzyme response, comprising the following raw materials: sevoflurane, a biocompatible polymer, a cross-linking agent, and a responsive component.

[0006] Preferably, the biocompatible polymer comprises polyethylene glycol, hyaluronic acid, or Pluronic F127.

[0007] Preferably, the responsive component comprises a pH-sensitive or enzyme-sensitive polymer.

[0008] Preferably, the pH-sensitive polymer includes polyacrylic acid, methacrylic acid, and polyamine;

[0009] The enzyme-sensitive polymer includes polyacetylimidazole and multifunctional polymer micelle.

[0010] A process for preparing a sevoflurane injection hydrogel having both pH and enzyme responses comprises the following steps:

[0011] Step 1: Encapsulate sevoflurane in a polymer matrix using emulsion or nanoparticle technology, and uniformly disperse sevoflurane in a hydrogel prepolymer by chemical or physical methods;

[0012] Step 2: Form a hydrogel at room temperature or body temperature through photopolymerization or chemical cross-linking reaction, and adjust the polymer concentration and cross-linking density to control the mechanical properties and drug release rate of the hydrogel.

[0013] Compared with the related art, the sevoflurane injection hydrogel with both pH and enzyme response and its preparation process provided by the present invention have the following beneficial effects:

[0014] The present invention provides a sevoflurane injection hydrogel with both pH and enzyme responses and a preparation process thereof. By selecting a pH-sensitive or enzyme-sensitive polymer, the pH value of a local area decreases after myocardial infarction. Therefore, the pH-sensitive hydrogel can responsively release drugs in such an acidic environment, and the corresponding enzymes will also change, thereby allowing the hydrogel to release sevoflurane under specific stimulation, thereby effectively protecting the myocardium.

[0015] This allows the hydrogel to effectively increase the timeliness and effectiveness of the response to myocardial injury, thereby greatly improving the effect of use. DETAILED DESCRIPTION

[0016] The technical solutions in the embodiments of the present invention will be described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0017] Embodiment 1:

[0018] The present invention provides a technical solution: a sevoflurane injection hydrogel with both pH and enzyme responses, comprising the following raw materials: sevoflurane, a biocompatible polymer, a cross-linking agent, and a responsive component.

[0019] Biocompatible polymers include polyethylene glycol, hyaluronic acid, or Pluronic F127.

[0020] Responsive components include pH-sensitive or enzyme-sensitive polymers.

[0021] pH-sensitive polymers include polyacrylic acid, methacrylic acid, and polyamines;

[0022] Enzyme-sensitive polymers include polyacetylimidazole and multifunctional polymer micelles.

[0023] Embodiment 1:

[0024] A process for preparing a sevoflurane injection hydrogel having both pH and enzyme responses comprises the following steps:

[0025] Step 1: Encapsulate sevoflurane in a polymer matrix using emulsion or nanoparticle technology, and uniformly disperse sevoflurane in a hydrogel prepolymer by chemical or physical methods;

[0026] Step 2: Form a hydrogel at room temperature or body temperature through photopolymerization or chemical cross-linking reaction, and adjust the polymer concentration and cross-linking density to control the mechanical properties and drug release rate of the hydrogel.

Claims

1. A sevoflurane injection hydrogel having both pH and enzyme responses, characterized in that: The invention comprises the following raw materials: sevoflurane, a biocompatible polymer, a cross-linking agent and a responsive component.

2. The sevoflurane injection hydrogel having both pH and enzyme responses according to claim 1, characterized in that: The biocompatible polymer includes polyethylene glycol, hyaluronic acid, or Pluronic F127.

3. The sevoflurane injection hydrogel having both pH and enzyme responses according to claim 2, characterized in that: The responsive component includes a pH-sensitive or enzyme-sensitive polymer.

4. The sevoflurane injection hydrogel having both pH and enzyme responses according to claim 3, characterized in that: The pH-sensitive polymers include polyacrylic acid, methacrylic acid, and polyamines; The enzyme-sensitive polymer includes polyacetylimidazole and multifunctional polymer micelle.

5. A process for preparing a hydrogel for sevoflurane injection having both pH and enzyme responses according to any one of claims 1 to 4, characterized in that: The following steps are involved: Step 1: Encapsulate sevoflurane in a polymer matrix using emulsion or nanoparticle technology, and uniformly disperse sevoflurane in a hydrogel prepolymer by chemical or physical methods; Step 2: Form a hydrogel at room temperature or body temperature through photopolymerization or chemical cross-linking reaction, and adjust the polymer concentration and cross-linking density to control the mechanical properties and drug release rate of the hydrogel.