Traditional Chinese medicine composition for treating diabetes

Abstract

The invention discloses a traditional Chinese medicine composition for treating diabetes, and relates to the technical field of traditional Chinese medicines, and the traditional Chinese medicine composition comprises the following traditional Chinese medicine components: cortex cinnamomi, cortex phellodendri, radix rehmanniae, dogwood, Chinese yam, cortex moutan, poria cocos, rhizoma alismatis, eucommia ulmoides, rhizoma atractylodis and fructus amomi. The traditional Chinese medicine composition is used for treating or relieving type 2 diabetes mellitus and symptoms such as dry mouth, polydipsia, diuresis and lumbago, has a good curative effect on the type 2 diabetes mellitus, and is reasonable in formula, free of toxic and side effects and safe and reliable in curative effect.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating type 2 diabetes. Background Art

[0002] Type 2 diabetes is a group of endocrine and metabolic diseases with very complex etiologies. It is a group of clinical syndromes of chronic hyperglycemia. Its basic pathophysiology is absolute or relative insulin deficiency and reduced sensitivity of target cells to insulin, which leads to metabolic disorders of sugar, protein, fat and secondary water and electrolytes. In severe cases, it can cause acid-base imbalance. Its characteristics are: high blood sugar, urine sugar, decreased glucose tolerance and abnormal insulin release test. Clinical manifestations include polydipsia, polyphagia, polyuria, thirst, hunger, weight loss, fatigue and other symptoms. Due to genetic factors, environmental factors, lifestyle factors and mental factors, diabetic patients suffer from immune dysfunction, which leads to increased interleukin reactivity and promotes lymphocyte infiltration in pancreatic cells. The infiltrated cells produce lymphokine, a factor that counteracts insulin function damage. Lymphokine blocks the blood circulation of pancreatic B cells, kills pancreatic B cells and sugar carrier genes, destroys all links of insulin secretion, excretion and transport, causes damage to pancreatic function, and causes diabetes and diabetic complications. Type 2 diabetes, formerly known as non-insulin-dependent diabetes, accounts for about 90% of all diabetic patients, and most patients develop the disease after the age of 35. There are many drugs for treating this disease, including Western medicine and traditional Chinese medicine. Commonly used Western medicines include sulfonylureas and glinides (glimepiride, glipizide, gliclazide, glyburide, repaglinide, nateglinide, mitiglinide), biguanides (metformin), thiazolidinediones (pioglitazone, rosiglitazone, enoglitazone, japagliflozin), GLP-1 receptor agonists (liraglutide, exenatide, dulaglutide, semaglutide, lixisenatide, tezetide), DPP-4 inhibitors (sitagliptin, linagliptin, vildagliptin, saxagliptin, alogliptin, alogliptin, alogliptin, empagliflozin, gemagliflozin, gopagliflozin), SGLT-2 inhibitors (empagliflozin, dapagliflozin, canagliflozin, erpagliflozin, soogliflozin, bepagliflozin, empagliflozin), insulin, etc. Among them, sulfonylureas and glinides, biguanides, thiazolidinediones, GLP-1 receptor agonists, and SGLT-2 inhibitors, although they have strong hypoglycemic effects, have many adverse reactions such as weight gain (sulfonylureas and glinides, thiazolidinediones, insulin), increased risk of cardiovascular disease (thiazolidinediones, GLP-1 receptor agonists, SGLT-2 inhibitors), hypoglycemia (sulfonylureas and glinides, insulin), gastrointestinal reactions (biguanides, SGLT-2 inhibitors), lactic acidosis (biguanides), genitourinary system infections (SGLT-2 inhibitors), edema and fractures (thiazolidinediones). These adverse reactions cause low treatment compliance rates in diabetic patients, and also limit the therapeutic effects and clinical applications of drugs. In addition, various Western medicine treatments require lifelong medication, and it is difficult to completely get rid of drugs and restore their own functions.

[0003] The field of traditional Chinese medicine has explored some understandings of the pathogenesis and effective prescriptions and drugs, such as Xiaoke Pills, Liuwei Dihuang Pills, Jinkui Shenqi Pills, Yuye Decoction, Huanglian, etc. However, there are two problems. First, the effects are not certain enough, and the effects reflected in different patients, different regions, and different seasons are not stable enough. Second, the blood sugar lowering effect is not strong, and it is difficult to reach or exceed the effect of Western medicine. In clinical practice, Western medicine is often used for synergistic treatment.

[0004] Therefore, it is urgent to design a Chinese medicine composition for treating diabetes to solve the above problems. Summary of the invention

[0005] In view of the defects of the above-mentioned prior art, the purpose of the present invention is to provide a Chinese medicine composition for treating diabetes. The Chinese medicine composition is a new prescription formed by adding 5 drugs to the traditional Chinese medicine prescription Liuwei Dihuang Pills, and is proposed to be named "Erpi Dihuang Decoction". It has the clinical effect of lowering blood sugar and improving diabetes-related symptoms.

[0006] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0007] A traditional Chinese medicine composition for treating diabetes comprises the following traditional Chinese medicine raw materials in parts by weight: 6-18 parts of cinnamon bark, 6-18 parts of phellodendron, 18-30 parts of radix rehmanniae, 18-30 parts of cornus officinalis, 18-30 parts of yam, 6-18 parts of moutan bark, 6-18 parts of tuckahoe, 6-18 parts of oriental alisma, 9-30 parts of eucommia bark, 6-30 parts of atractylodes, and 3-9 parts of amomum.

[0008] Preferably, the dosage form of the Chinese medicine composition is an oral dosage form, and the oral dosage form is granules, tablets, capsules, pills, syrups, powders, pastes, pellets, suspensions, emulsions, sustained-release preparations or controlled-release preparations.

[0009] Preferably, the preparation method of the Chinese medicine composition comprises:

[0010] S1. Take each medicinal material according to the portion, soak the medicinal materials for 30 to 60 minutes, and add water;

[0011] S2. After boiling over high heat, turn to low heat and simmer for 40 minutes, then pour out the soup;

[0012] S3. Continue to add water, and the amount of water added to the second decoction is 1 / 2 to 1 / 3 of the first decoction;

[0013] S4. Remove the residue from the two decoctions, filter them and mix them.

[0014] In another aspect, the present invention provides a use of a traditional Chinese medicine composition in preparing a drug for type 2 diabetes.

[0015] The properties, flavors, meridians and effects of the Chinese medicinal materials used in the present invention are as follows:

[0016] Cinnamon bark: It tastes spicy and sweet, is very hot in nature, and enters the kidney, spleen, and bladder meridians. It has the effects and functions of replenishing fire and yang, guiding fire back to the origin, dispersing cold and relieving pain, and warming and unblocking the meridians.

[0017] Phellodendron chinense: bitter in nature and cold in flavor, enters the kidney, bladder, and large intestine meridians, has the effects of clearing away heat and dampness, purging fire and detoxifying, and eliminating bone steaming;

[0018] Shengdi: Sweet and bitter in nature, cold in nature, enters the heart, liver, and kidney meridians, and has the effects of clearing away heat, cooling blood, nourishing yin, and promoting the production of body fluids;

[0019] Cornus officinalis: sour, astringent, slightly warm in nature, enters the liver and kidney meridians, and has the effect of nourishing the liver and kidneys;

[0020] Chinese Yam: It is sweet and mild in nature, and enters the spleen, stomach, lung and kidney meridians. It has the effects of replenishing qi, nourishing yin, tonifying spleen, lung and kidney, and consolidating essence and stopping leukorrhea.

[0021] Cortex Moutan: It is cold in nature and tastes bitter and pungent. It belongs to the heart, liver and kidney meridians. It has the effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis.

[0022] Poria: sweet and mild in nature, neutral in nature, enters the heart, lung, spleen, and kidney meridians, has the effects of promoting diuresis and eliminating dampness, strengthening the spleen and calming the mind;

[0023] Alisma: sweet in nature and flavor, it enters the kidney and bladder meridians, and has the effects of promoting diuresis and eliminating dampness, relieving heat, and lowering blood lipids.

[0024] Eucommia ulmoides: sweet and warm in nature, it enters the liver and kidney meridians, has the effects of strengthening tendons and bones, lowering blood pressure, anti-inflammatory and antioxidant, nourishing yin and liver, and enhancing the immune system;

[0025] Atractylodes: pungent and bitter in taste, warm in nature, enters the spleen, stomach, and liver meridians, has the effects of drying dampness and strengthening the spleen, removing rheumatism, dispelling cold and relieving exterior symptoms, and improving eyesight;

[0026] Amomum villosum: warm in nature and pungent in flavor, it enters the spleen, stomach, and kidney meridians, and has the effects of removing dampness, promoting qi circulation, warming the middle and stopping vomiting;

[0027] The beneficial effects of the present invention are as follows: the present invention discloses a Chinese medicine composition for treating diabetes. Compared with the prior art, the present invention has the following improvements:

[0028] The Chinese medicine prescription of the present invention is a new prescription formed by adding 5 drugs to the traditional Chinese medicine prescription Liuwei Dihuang Pill, which is proposed to be named "Erpi Dihuang Decoction". It has the effect of lowering blood sugar and improving diabetes-related symptoms. The creation of this prescription is based on the innovative understanding of the pathogenesis of type 2 diabetes in Chinese medicine, and it is believed that "wet soil hurts the kidney and kidney qi is not solid" is the fundamental pathogenesis of type 2 diabetes. Overeating, eating fat and sweet food, lack of exercise, etc. can lead to obesity and excessive wet soil; excessive drinking, staying up late and fatigue, aging lead to damaged yin and insufficient kidney qi; wet soil is strong, kidney qi is weak, and the strong soil overcomes weak water, destroying the state of kidney qi storage, and finally forming kidney qi is not solid; soil is strong and water is weak, causing nutrition (blood sugar) to go from the kidney, glycosuria, and diabetes. The typical pulse in the clinic is that the radial pulse is solid and strong, and it does not stop when pressed, which belongs to the kidney pulse. Clinical practice shows that many early and early stage of type 2 diabetes also meet this pathogenesis.

[0029] Therefore, strengthening kidney qi and reversing the state of strong earth and weak water are the key to treating type 2 diabetes. This prescription absorbs the effective experience of using Liuwei Dihuang Pills to nourish kidney yin to treat type 2 diabetes, and then integrates the innovative theory of "skin medicine to strengthen the kidney". By adding three bark medicines, cinnamon, phellodendron, and eucommia, and two medicines with the effect of drying dampness and moving the spleen, Atractylodes and Amomum, it achieves the effect of improving the hypoglycemic effect and reducing adverse reactions.

[0030] Cinnamon and Phellodendron chinense are the main ingredients in Erpi Dihuang Decoction. Cinnamon draws fire back to the origin, while Phellodendron chinense is bitter and strengthens the kidney. Both of these medicines are tree barks, which can descend and astringe, and play the role of strengthening kidney Qi from different angles. Moreover, one of the two medicines is cold, and the other is hot. When used together, the cold and heat are neutralized, eliminating the adverse reactions caused by excessive cold or excessive heat.

[0031] Eucommia bark, moutan bark, raw rehmannia root, cornus officinalis, and Chinese yam are all assistant drugs. Eucommia bark is also a tree bark, which is good at nourishing the liver and kidney, strengthening the tendons and bones, and can help the main drug to strengthen the kidney; moutan bark is a root bark, which can clear the deficiency fire in the kidney and help the main drug to restore the kidney qi; raw rehmannia root nourishes kidney yin to strengthen the kidney; cornus officinalis is sour and can be astringent, and can nourish the liver and strengthen the liver and kidney; Chinese yam is rich in mucus, which can nourish kidney fluid. When the kidney fluid is sufficient, the deficiency fire will be cleared, which helps to strengthen the kidney, so they are all assistant drugs.

[0032] Atractylodes and Amomum villosum invigorate the spleen and dry dampness, while Poria and Alisma orientalis promote diuresis and eliminate dampness, eliminating excess dampness and earth, targeting the pathogenesis more comprehensively and supplementing the deficiencies of the main and auxiliary functions, and together they serve as adjuvants.

[0033] The above three groups of medicines are used together to achieve the effect of consolidating kidney qi and draining dampness and earth, closely following the pathogenesis of "dampness and earth hurting the kidney, and kidney qi is not solid", and have good clinical effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 This is a comparison chart of blood sugar levels of rats in each group in the animal experiment of the present invention;

[0035] Figure 2This is a comparison chart of the water drinking amount of rats in each group in the animal experiment of the present invention;

[0036] Figure 3 This is a comparison chart of the urine volume of rats in each group in the animal experiment of the present invention;

[0037] Figure 4 This is a comparison of HE staining and PAS staining of liver tissue pathological sections of rats in the control group, model group, and medication group in the animal experiment of the present invention;

[0038] Figure 5 The figure is a comparison of pancreatic tissue pathological sections of rats in the control group, model group and medication group in the animal experiment of the present invention. DETAILED DESCRIPTION

[0039] In order to enable those skilled in the art to better understand the technical solution of the present invention, the technical solution of the present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0040] Embodiment 1:

[0041] A Chinese medicine composition for treating diabetes, comprising the following Chinese medicine raw materials in parts by weight:

[0042] The first specific group allocation ratio:

[0043] 15 parts of cinnamon bark, 15 parts of phellodendron, 30 parts of raw rehmannia, 18 parts of cornus officinalis, 30 parts of yam, 9 parts of peony bark, 15 parts of tuckahoe, 9 parts of oriental water plantain, 30 parts of eucommia bark, 9 parts of atractylodes, and 3 parts of amomum.

[0044] Decoction preparation method:

[0045] 1. Take the herbs according to the above proportions and soak them for 30 to 60 minutes. Add water. It is best to add water above the surface of the herbs.

[0046] 2. After boiling over high heat, turn to low heat and simmer for 40 minutes, then pour out the soup.

[0047] 3. Continue to add water, and the amount of water added for the second decoction should be 1 / 3-1 / 2 of the first decoction;

[0048] 4. Remove the residue from the two decoctions, filter them out, and mix them to make this decoction.

[0049] Embodiment 2:

[0050] The second specific group distribution ratio:

[0051] 9 parts of cinnamon bark, 9 parts of phellodendron, 24 parts of raw rehmannia, 12 parts of cornus officinalis, 12 parts of yam, 9 parts of peony bark, 9 parts of tuckahoe, 9 parts of oriental water plantain, 30 parts of eucommia bark, 9 parts of atractylodes, and 3 parts of amomum.

[0052] Decoction preparation method:

[0053] 1. Take the herbs according to the above proportions and soak them for 30 to 60 minutes. Add water. It is best to add water above the surface of the herbs.

[0054] 2. After boiling over high heat, turn to low heat and simmer for 40 minutes, then pour out the soup.

[0055] 3. Continue to add water, and the amount of water added for the second decoction should be 1 / 3-1 / 2 of the first decoction;

[0056] 4. Remove the residue from the two decoctions, filter them out, and mix them to make this decoction.

[0057] Embodiment 3:

[0058] The third specific group allocation ratio:

[0059] 30 parts of cinnamon bark, 30 parts of phellodendron, 30 parts of raw rehmannia, 30 parts of cornus officinalis, 30 parts of yam, 15 parts of peony bark, 15 parts of poria, 12 parts of oriental water plantain, 30 parts of eucommia, 15 parts of atractylodes, and 6 parts of amomum.

[0060] Decoction preparation method:

[0061] 1. Take the herbs according to the above proportions and soak them for 30 to 60 minutes. Add water. It is best to add water above the surface of the herbs.

[0062] 2. After boiling over high heat, turn to low heat and simmer for 40 minutes, then pour out the soup.

[0063] 3. Continue to add water, and the amount of water added for the second decoction should be 1 / 3-1 / 2 of the first decoction;.

[0064] 4. Remove the residue from the two decoctions, filter them out, and mix them to make this decoction.

[0065] Embodiment 4:

[0066] Example 4 is an animal experiment of the Chinese medicine composition in Example 1. The experimental results show that the prescription has the effects of lowering blood sugar and improving symptoms.

[0067] 1. Materials and sources involved:

[0068] (1) Experimental mice: 48 SPF 8-week-old male SD rats weighing 180-220 g were housed in the Experimental Animal Center of Zhejiang Chinese Medical University. The animal experiment procedures followed the Animal Experimental Care and Use Standards of Zhejiang Chinese Medical University.

[0069] (2) Drugs: ErPi Di Huang Decoction (composition of the present invention), EPDHD (ErPi Di Huang Decoction), wherein the Chinese medicinal materials in the present invention are all purchased from Zhejiang Provincial Hospital of Traditional Chinese Medicine; all the medicinal materials are crushed and decocted with 2 times water for 1 hour each time, and the filtrates are combined and concentrated to a crude drug content of 2 g / ml, and stored at 4°C for later use after packaging; Metformin (MET), 500 mg / tablet;

[0070] (3) Instrument: blood glucose meter.

[0071] 2. Experimental Procedure

[0072] 2.1 Modeling: After 1 week of adaptation feeding, 8 rats were taken as the normal control group (CON) and fed with ordinary feed, and the rest of the rats were fed with high-fat feed for 8 weeks. In the 8th week, STZ (streptozotocin) (30 mg / kg) dissolved in 0.1 mol / L citrate buffer (pH = 4.5) was injected intraperitoneally to establish the model (on ice and away from light, prepared and used immediately), and the normal control group was injected with an equal amount of citrate buffer. Fasting blood glucose (FBG) in the tail vein was measured on the 3rd and 7th days after injection. The FBG levels of three times were >11.1 mmol / L, and the blood glucose level tended to be stable, which was considered to be a successful modeling of T2DM rats.

[0073] 2.2 Grouping and dosing: The rats with successful modeling were randomly divided into 5 groups according to blood glucose: model group (MOD), metformin group (MET), low-dose of Erpi Dihuang decoction (EPDHD-L), medium-dose (EPDHD-M), and high-dose (EPDHD-H) treatment group, with 6 rats in each group.

[0074] The medium-dose group of Erpi Dihuang Decoction (the oral dose of rats was 4-10 times that of adults, converted to 7 times in this experiment, the medium dose in this embodiment was 15.6g·kg-1, and the low-dose, medium-dose, and high-dose preparation concentration ratios were 1:2:4), and the drug was administered by oral administration at a crude drug concentration of 2g / ml, with 0.5ml of Erpi Dihuang Decoction solution administered by oral administration for every 100g of rat body weight; the metformin group (metformin 250mg·kg-1), 1ml of metformin solution was administered for every 100g of rat body weight; the control group and the model group were given distilled water daily, once a day by oral administration for 7 weeks. During the experiment, the normal control group was fed with ordinary feed, and the other experimental groups were fed with high-fat feed. The animal grouping and treatment are shown in Table 1;

[0075] Table 1 Animal groups and treatments

[0076]

[0077] 3. Experimental conclusion

[0078] (1) Lower fasting blood sugar

[0079] The model was established in the 8th week, and gavage was started in the 9th week. After 7 weeks of gavage, the fasting blood glucose of the Erpi Dihuang Tang gavage group (EPDH) was significantly lower than that of the model group (MOD), and the high-dose group and the medium-dose group of the Erpi Dihuang Tang gavage group were better than the low-dose group. The results are shown in the figure Figure 1 As shown;

[0080] (2) Reduce water intake

[0081] After 7 weeks of intragastric administration, the water intake of the Erpi Dihuang decoction group was significantly improved compared with the model group. Figure 2 As shown;

[0082] (3) Reduce urine volume

[0083] After 7 weeks of intragastric administration, the water intake of the low, medium and high doses of EPDHD groups was significantly improved compared with the model group. Figure 3 As shown;

[0084] (4) Improve liver lesions and increase liver glycogen

[0085] After 7 weeks of intragastric administration, HE staining of liver tissue sections showed that compared with the control group (CON), the liver cells in the model group (MOD) were smaller in size, loose and isolated, and the liver cells were atrophied and arranged in disorder. After treatment with Erpi Dihuang Decoction, the liver cells were normal in size, the intercellular spaces were reduced, and the arrangement was neat. PAS staining of liver tissue sections showed that a small amount of liver glycogen existed around the central vein in the control group (CON). Compared with the control group, the liver glycogen content in the model group (MOD) was significantly reduced (very rare). After treatment with Erpi Dihuang Decoction (EPDHD), the liver glycogen content was significantly increased, which was visible in each cell. The results are shown in the figure. Figure 4 As shown;

[0086] (5) Promote pancreatic islet cell regeneration

[0087] After 7 weeks of intragastric administration, pancreatic tissue pathological sections showed that the pancreatic islets in the control group (CON) were full and scattered between the pancreatic acini. They were round or oval cell clusters, arranged in cords, with clear boundaries, no obvious capsule, and regular outlines. Compared with the control group, the number of pancreatic islets in the model group (MOD) was significantly reduced (very rare), the area of ​​a single pancreatic islet was reduced, and the arrangement of pancreatic islet cells was disordered. After treatment with Erpi Dihuang Decoction (EPDHD), the number of pancreatic islets increased and the area of ​​pancreatic islets increased. Figure 5 As shown;

[0088] The conclusion of animal experiments shows that the Chinese medicine composition of the present invention has the effects of lowering blood sugar, improving urine volume and water intake, improving liver lesions, and promoting pancreatic islet cell regeneration in type 2 diabetic rats.

[0089] Embodiment 5:

[0090] Example 5 is a clinical study on the Chinese medicine composition in Example 1 for type 2 diabetes.

[0091] Case 1;

[0092] Zhu, male, 51 years old, visited the hospital on March 9, 2024, and was found to have elevated blood sugar for 1 year. He was diagnosed with type 2 diabetes for 1 year. He is currently taking 1 tablet of metformin and glimepiride orally. His fasting blood sugar was 14.3mmol / L on the morning of February 10, and 10.9mmol / L on the morning of March 9. The two pulses Guan and Chi are stringy and strong, and Cun is deep, which is consistent with the syndrome of weak kidney qi. He was given Erpi Dihuang Decoction with modifications, and western medicine was taken as before. The specific prescriptions are as follows: 12g cinnamon bark, 12g stir-fried phellodendron, 18g raw rehmannia, 18g cooked rehmannia, 18g cornus officinalis, 30g yam, 9g moutan bark, 30g poria, 9g orientalis, 9g French pinellia, 18g eucommia, 9g atractylodes, and 3g amomum.

[0093] Take one dose per day, decocted in water, for a total of 12 doses, and ask the patient to measure fasting blood sugar once every 3 days or so; follow-up visit on March 30, 2024, self-measured fasting blood sugar on March 13, March 17, March 20, and March 24, were 10.8mmol / L, 10.5mmol / L, 9.8mmol / L, and 10.3mmol / L respectively, and the average of the four blood sugar levels was 10.35mmol / L. Both pulses were deep and stringy at the inch and guan positions, and turbid and strong when pressed at the chi position. The treatment plan after the follow-up visit is: keep the previous prescription and remove the Pinellia ternata, add 18g of stir-fried Atractylodes macrocephala, one dose per day, decocted in water, for a total of 12 doses.

[0094] On April 13, 2024, the patient had another follow-up visit. The fasting blood sugar levels on April 5, April 7, April 9, April 11, and April 12 were 10.3mmol / L, 10.9mmol / L, 6.7mmol / L, 8.6mmol / L, and 9.1mmol / L, respectively. The average blood sugar level for the five visits was 9.12mmol / L. The pulses on both wrists were smooth, large, solid, and strong. The treatment plan after the follow-up visit was: continue to take the following prescription medicine, one dose per day, for a total of 12 doses; the prescription medicine was: 15g cinnamon bark, 15g phellodendron, 18g radix rehmanniae, 18g cooked radix rehmanniae, 18g cornus officinalis, 30g yam, 9g moutan bark, 30g poria, 9g orientalis, 18g stir-fried atractylodes macrocephala, 30g eucommia, 9g atractylodes, and 3g amomum;

[0095] On April 27, 2024, the patient was re-examined. The fasting blood sugar was measured on April 16, April 19, April 22, April 24, April 26, and April 27, which were 8mmol / L, 8.7mmol / L, 10.2mmol / L, 8.3mmol / L, 8.4mmol / L, and 7.5mmol / L, respectively. The average blood sugar of the six times was 8.52mmol / L. The pulses were turbid, slippery, solid, slightly stringy, and strong. The treatment plan after diagnosis was: keep the previous prescription and add 6g of Acanthopanax Cortex, one dose per day, for a total of 12 doses.

[0096] The patient was followed up on May 11, 2024. The fasting blood sugar levels on April 29, May 1, May 3, May 5, May 7, May 9, and May 11 were 7.8mmol / L, 8.8mmol / L, 8.8mmol / L, 8.4mmol / L, 7.7mmol / L, 8.1mmol / L, and 7.7mmol / L respectively. The average value of the seven times was 8.19mmol / L.

[0097] Conclusion: After taking the Chinese herbal decoction of Example 1 for 2 weeks, 4 weeks, 6 weeks and 8 weeks, the average fasting blood glucose levels of the patient were 10.35mmol / L, 9.12mmol / L, 8.52mmol / L and 8.19mmol / L, respectively, showing a downward trend, indicating that the Chinese herbal decoction can lower blood glucose.

[0098] Case 2:

[0099] Yang, male, 27 years old, first diagnosed on February 20, 2024. Due to work reasons, the patient stayed up late for a long time. In the past six months, he had dry mouth, bitter mouth, bad breath, and polydipsia. He drank several liters of water every day, had frequent urination, especially nocturia, backache, and strong pulses. The diagnosis was consistent with the syndrome of kidney qi instability. He was suspected of having abnormal blood sugar. He was asked to measure his blood sugar and check for diabetes. He was given the Chinese medicine decoction of Example 1 plus stir-fried white atractylodes for treatment. The prescription was as follows: 12g of cinnamon bark, 12g of stir-fried phellodendron, 18g of raw rehmannia, 18g of cooked rehmannia, 18g of cornus officinalis, 30g of yam, 9g of moutan bark, 15g of poria, 9g of oriental rhizome, 3g of amomum, 3g of oxyphylla, 30g of eucommia, 18g of stir-fried white atractylodes, and 6g of atractylodes; one dose per day, decocted in water, a total of 7 pairs;

[0100] On March 26, 2024, the patient informed that on February 29, after checking blood sugar and blood insulin levels, he was diagnosed with type 2 diabetes and started taking metformin. The patient reported that after taking the Chinese medicine decoction of the present invention, the symptoms of dry mouth, polydipsia, polyuria, low back pain, etc. were alleviated, and the two pulses were strong and continuous when pressed. The treatment plan after the follow-up visit was: keep the previous prescription plus 30g of mistletoe and 9g of Uncaria rhynchophylla, one dose per day, decocted in water, a total of 12 packs;

[0101] During the follow-up visit on April 23, 2024, he was told that he had stopped taking metformin on April 8 and had only been taking Chinese medicine since then. His fasting blood sugar was 5.8mmol / L on April 23. His fasting blood sugar was measured three times on April 10, April 17, and April 23, which were 7.8mmol / L, 8.7mmol / L, and 7.7mmol / L respectively (he did not take Western medicine).

[0102] Conclusion: The patient's symptoms were alleviated after taking the Chinese herbal decoction of the present invention for several days, and was later diagnosed with type 2 diabetes. The symptoms did not rebound after stopping the western medicine, and the blood sugar level was still kept lower than before treatment after stopping the western medicine, indicating that the Chinese herbal decoction of the present invention has a definite effect in improving diabetes-related symptoms.

[0103] Case 3:

[0104] Yang, male, 55 years old, first diagnosed on October 22, 2023, diagnosed with diabetes for many years, with high blood lipids and high uric acid; self-tested fasting blood sugar is between 6.3-8.9mmol / L, taking Gehuazhi + Baitangping three times a day, symptoms are backache, two feet pulse slow, smooth and strong, given the Chinese medicine decoction of the present invention for treatment, the specific prescription is as follows: cinnamon 15g, phellodendron 15g, raw earth 18g, cooked earth 18g, cornus 18g, yam 30g, moutan bark 9g, Poria 18g, oriental rhizome 9g, eucommia 30g, stir-fried atractylodes 18g, atractylodes 9g, amomum 4g, polygala 9g, stir-fried phellodendron 6g, one dose per day, decocted in water, a total of 12 pairs;

[0105] On November 5, 2023, the patient was re-examined. His fasting blood sugar was between 6.1-7.4mmol / L recently. He complained that his postprandial blood sugar was significantly lower than before. His pulse was slow, smooth, turbid and solid. He was advised to reduce the hypoglycemic medication to twice a day, and add 15g of Acanthopanax Cortex to the previous prescription, one dose per day, decocted in water, for a total of 12 doses;

[0106] On November 19, 2023, the patient had a follow-up visit. His fasting blood sugar was mostly between 6.8-6.9mmol / L. His blood sugar after meals was lower than before. He had changed his blood sugar-lowering drugs (Glucovalve + Bayer) to twice a day for the past two weeks. His pulse was slow, smooth, solid, and slightly turbid. He kept his pulse forward. He took one dose a day, decocted in water, for a total of 12 doses.

[0107] The patient was re-examined on December 3, 2023. His blood sugar has been between 6.4-8.2mmol / L recently. He reported that he had stopped taking Glucose Bayer since November 30 and only took Glucose once in the morning and evening. The glycated hemoglobin level was lower than before when checked on December 1.

[0108] Conclusion: After taking 36 doses of the Chinese herbal decoction of the present invention, the patient's fasting blood sugar and glycosylated hemoglobin were reduced, and the effect was achieved under the condition of reducing the use of Western medicine, indicating that Erpi Dihuang Decoction helps patients reduce the use of Western medicine for hypoglycemia and has the effect of lowering blood sugar.

[0109] The above shows and describes the basic principles, main features and advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments, and the above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A Chinese medicine composition for treating diabetes, characterized in that: The invention comprises the following Chinese medicinal raw materials in parts by weight: 6-18 parts of cinnamon bark, 6-18 parts of phellodendron, 18-30 parts of radix rehmanniae, 18-30 parts of cornus officinalis, 18-30 parts of yam, 6-18 parts of moutan bark, 6-18 parts of tuckahoe, 6-18 parts of oriental arisaema, 9-30 parts of eucommia bark, 6-30 parts of atractylodes, and 3-9 parts of amomum villosum.

2. A Chinese medicine composition according to claim 1, characterized in that: The dosage form of the Chinese medicine composition is an oral dosage form, and the oral dosage form is granules, tablets, capsules, pills, syrups, powders, pastes, pellets, suspensions, emulsions, sustained-release preparations or controlled-release preparations.

3. A method for preparing a Chinese medicine composition according to any one of claims 1 to 2, characterized in that: include: S1. Take each medicinal material according to the portion, soak the medicinal materials for 30 to 60 minutes, and add water; S2. After boiling over high heat, turn to low heat and simmer for 40 minutes, then pour out the soup; S3. Continue to add water, and the amount of water added to the second decoction is 1 / 3-1 / 2 of the first decoction; S4. Remove the residue from the two decoctions, filter them and mix them.

4. Use of the Chinese medicine composition according to claim 3 in preparing drugs for type 2 diabetes.

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