Traditional Chinese medicine composition for treating hyperplasia of mammary glands and lymphadenectasis

Abstract

The invention discloses a traditional Chinese medicine composition for treating hyperplasia of mammary glands and lymphadenectasis, which consists of codonopsis pilosula, frankincense, myrrh, dysosma versipellis, gum of ailanthus altissima, safflower, semen cuscutae and glycyrrhiza uralensis, the codonopsis pilosula and the safflower are used as monarch drugs to achieve the effects of promoting qi to activate blood and promoting qi movement, and the qi moves to promote blood circulation and promote channels and collaterals to be unblocked; the semen cuscutae is used as a ministerial drug to tonify the kidney to strengthen the excess and help the monarch drug to enhance the capacity of transporting qi and promoting blood circulation, the frankincense, the myrrh, the dysosma versipellis and the ailanthus gum are used as adjuvant drugs, the frankincense and the myrrh are compatible to achieve the effects of activating blood and diminishing swelling, the dysosma versipellis and the ailanthus gum are compatible to achieve the effects of clearing heat, diminishing swelling and being compatible together to achieve the effects of eliminating stagnation and relieving pain, and the liquorice is used as a conductant drug to harmonize the medicines to achieve the effects of promoting qi and blood circulation and promoting qi circulation. The traditional Chinese medicine composition has the functions of treating qi stagnation and blood stasis, removing stasis, eliminating stagnation and removing blood stasis, effectively treats qi stagnation and blood stasis type hyperplasia of mammary glands, has the effects of eliminating stagnation and eliminating swelling, and also has an effective treatment effect on lymphadenectasis.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating breast hyperplasia and lymphadenopathy. Background Art

[0002] Breast hyperplasia is a common clinical disease. After the onset of the disease, patients will experience obvious breast pain and breast lumps, and may also have breast discharge. It is characterized by a long course of disease, slow development, and easy recurrence. Treatment needs to be started as soon as possible. If not treated in time, cancer may occur.

[0003] Western medicine believes that the onset of breast hyperplasia is related to endocrine disorders and mental factors, especially the imbalance of the hypothalamus-pituitary-ovary-breast endocrine axis. Ovarian secretion dysfunction leads to a decrease in progesterone secretion and a relative increase in estrogen, which ultimately causes breast epithelial and fibrous tissue hyperplasia, structural degenerative changes in breast tissue ducts and lobules, and progressive connective tissue growth. Western medicine mostly uses hormones, vitamins, iodine and other symptomatic treatment drugs, which can regulate the level of estrogen and progesterone in the body and relieve pain, but a high proportion of patients will experience side effects such as hot flashes, night sweats, headaches, irritability, scanty menstruation, and even amenorrhea after taking the drugs, and the disease is prone to relapse after stopping the drugs.

[0004] Traditional Chinese medicine believes that breast hyperplasia falls under the category of "breast problems" in traditional Chinese medicine. Although there are many drug treatments, some of them have long treatment courses and are not very effective. Summary of the invention

[0005] Therefore, based on the above background, the present invention provides a Chinese medicine composition for treating breast hyperplasia and lymphadenopathy. The drugs of the present invention are rationally compatible and can work together to promote qi and blood circulation, promote the flow of qi, disperse nodules and reduce swelling, and relieve stagnation and resolve blood stasis, so as to effectively treat breast hyperplasia of qi stagnation and blood stasis type.

[0006] The technical solution of the present invention is:

[0007] A Chinese medicine composition for treating breast hyperplasia and lymphadenopathy, comprising the following raw materials by weight:

[0008] 25-40 parts of Codonopsis pilosula, 20-30 parts of frankincense, 20-30 parts of myrrh, 15-25 parts of Illicium barometz, 10-20 parts of toon gum, 20-30 parts of safflower, 10-15 parts of Cuscuta australis, and 5-10 parts of liquorice.

[0009] Preferably, it consists of the following raw materials by weight:

[0010] 30 parts of Codonopsis pilosula, 20 parts of frankincense, 20 parts of myrrh, 15 parts of Illicium barometz, 15 parts of toon gum, 25 parts of safflower, 15 parts of Cuscuta australis, and 5-10 parts of liquorice.

[0011] Preferably, it consists of the following raw materials by weight:

[0012] 35 parts of Codonopsis pilosula, 20 parts of frankincense, 20 parts of myrrh, 20 parts of Illustris odoratus, 20 parts of Toona sinensis, 30 parts of safflower, 15 parts of Cuscuta australis, and 5-10 parts of liquorice.

[0013] Preferably, it consists of the following raw materials by weight:

[0014] 25 parts of Codonopsis pilosula, 20 parts of frankincense, 20 parts of myrrh, 15 parts of Illicium barometz, 10 parts of toon gum, 20 parts of safflower, 15 parts of Cuscuta australis, and 5-10 parts of liquorice.

[0015] Preferably, a medically acceptable adjuvant is added to prepare an oral preparation.

[0016] Furthermore, the oral preparation is one of a decoction, an oral liquid, a granule, a tablet, a capsule, and a pill.

[0017] Furthermore, the preparation method of the decoction is:

[0018] Take each raw material drug according to the amount, crush them separately, and mix them together;

[0019] Add 20-30 times the weight of water to the mixed API, soak for 1-2 hours, boil over high heat, then simmer over low heat for 1.5-3 hours, and filter;

[0020] Add 8-10 times the weight of water to the filtered residue, boil it over high heat, then simmer it over low heat for 20-40 minutes, and filter it; combine the two filtrates.

[0021] Based on the same inventive concept, the present invention applies the above-mentioned Chinese medicine composition to prepare medicines, characterized in that the medicines are used to treat any of the following diseases:

[0022] 1) Breast hyperplasia;

[0023] 2) Breast hyperplasia with enlarged axillary lymph nodes;

[0024] 3) Swollen lymph nodes.

[0025] Furthermore, the syndrome type of breast hyperplasia is qi stagnation and blood stasis type.

[0026] The medicines of each raw material of the present invention are shown below:

[0027] Codonopsis is sweet and mild, not dry or greasy, enters the spleen and lung meridians, replenishes qi and produces body fluids, nourishes blood, and can treat symptoms such as body fluid deficiency and blood deficiency, replenishes the middle qi, regulates qi and relieves the middle qi. Frankincense is pungent and dispersing, bitter and warm, enters the heart, liver, and spleen meridians, and is good at activating blood circulation. When blood is activated, pain is relieved, tendons are stretched, swelling is reduced, and muscles are regenerated. Therefore, it can activate blood circulation to stop pain, reduce swelling, regenerate muscles, and stretch tendons. Myrrh is pungent and dispersing, bitter and purging, aromatic and non-biased, enters the heart, liver, and spleen meridians, and is good at activating blood circulation. When blood is activated, pain is relieved, swelling is reduced, and muscles are regenerated. Therefore, it has the functions of relieving pain, reducing swelling, and regenerating muscles. The octagonal lotus clears away heat and detoxifies, promotes blood circulation and dissipates blood stasis; the Chinese toon gum, that is, the Chinese toon gum, clears away heat and detoxifies, has anti-inflammatory and swelling effects; the safflower promotes blood circulation and dissipates blood stasis, promotes menstruation and dissipates swelling, dissipates blood stasis and relieves pain; the dodder seed is sweet, pungent and moist, has a neutral and slightly warm nature, balances yin and yang, and has a firm and astringent effect; it enters the kidney meridian, is good at replenishing yang and yin, consolidating essence and reducing urine, and treats impotence due to kidney deficiency, spermatorrhea, frequent urination, and leukorrhea; it enters the liver and spleen meridians, is good at nourishing the liver and improving eyesight, replenishing the spleen and stopping diarrhea, and treats blurred vision and diarrhea due to spleen deficiency. In addition, by replenishing the liver and kidney, it can also stabilize the fetal essence, and by regulating yin and yang, it can also produce body fluids and quench thirst, and treat kidney deficiency, restless fetal movement, and thirst. Licorice replenishes qi and nourishes the middle, removes phlegm and stops coughs, detoxifies, relieves urgency and stops pain, and moderates the properties of the medicine.

[0028] Qi stagnation and blood stasis type breast hyperplasia is often manifested as local breast tingling and distending pain, with a fixed position; a lump with unclear boundaries and tough texture can be touched. Qi stagnation and blood stasis type breast hyperplasia is mostly caused by blood stasis blocking the collaterals and poor qi movement. Blood stasis and qi stagnation block the breast meridians, causing lumps to gradually appear in the breast, leading to symptoms such as breast pain and swelling. Therefore, the present invention uses Codonopsis pilosula, safflower, Illicium verum, and Chinese toon gum as the main medicines to promote blood circulation and dissipate blood stasis, dissipate stagnation and reduce swelling, and achieve the effects of promoting qi and blood circulation, promoting qi circulation, and promoting qi circulation. The circulation of Qi leads to the circulation of blood, which promotes the unblocking of meridians. Cuscuta australis is used as the assistant medicine to nourish the kidney and strengthen the body, so as to help the main medicine enhance the power of qi and blood circulation. Frankincense and myrrh are used as adjuvants to help the main medicine to activate blood circulation and reduce swelling. Licorice is used as the guiding medicine to harmonize all the medicines, so as to play the role of activating Qi and blood circulation, unblocking Qi, dispersing nodules and reducing swelling, and relieving stagnation and removing blood stasis, so as to effectively treat breast hyperplasia of Qi stagnation and blood stasis type, and its effect of dispersing nodules and reducing swelling can also have an effective therapeutic effect on swollen lymph nodes. DETAILED DESCRIPTION

[0029] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with its embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0030] Example 1: A Chinese medicine composition for treating breast hyperplasia and lymphadenopathy, which is composed of the following raw materials by weight:

[0031] 30 parts of Codonopsis pilosula, 20 parts of frankincense, 20 parts of myrrh, 15 parts of Illicium barometz, 15 parts of toon gum, 25 parts of safflower, 15 parts of Cuscuta australis, and 5 parts of liquorice.

[0032] Example 2: A Chinese medicine composition for treating breast hyperplasia and lymphadenopathy, which is composed of the following raw materials by weight:

[0033] 35 parts of Codonopsis pilosula, 20 parts of frankincense, 20 parts of myrrh, 20 parts of Illustris umbellatae, 20 parts of Toona sinensis, 30 parts of Carthamus tinctorius, 15 parts of Cuscuta australis, and 5 parts of Licorice.

[0034] Example 3: A Chinese medicine composition for treating breast hyperplasia and lymphadenopathy, which is composed of the following raw materials by weight:

[0035] 25 parts of Codonopsis pilosula, 20 parts of frankincense, 20 parts of myrrh, 15 parts of Illicium barometz, 10 parts of toon gum, 20 parts of safflower, 15 parts of Cuscuta australis, and 5 parts of liquorice.

[0036] The Chinese medicine compositions of Examples 1 to 3 can be made into decoctions for oral administration. The preparation method of the decoctions is as follows:

[0037] Take each raw material drug according to the amount, crush them separately, and mix them together;

[0038] Add 20-30 times the weight of water to the mixed API, soak for 1-2 hours, boil over high heat, then simmer over low heat for 1.5-3 hours, and filter;

[0039] Add 8-10 times the weight of water to the filtered residue, boil it over high heat, then simmer it over low heat for 20-40 minutes, and filter it; combine the two filtrates.

[0040] When used, the combined filtrate is packaged in bottles, 25 ml per bottle.

[0041] Example 4: Application Information

[0042] (1) From December 2023 to March 2024, 31 patients were diagnosed with breast hyperplasia who visited our clinic. All patients were female, aged between 25 and 42 years old, with a course of disease of 6 to 28 months, 12 of whom had unilateral disease and 19 had bilateral disease. All patients were diagnosed with qi stagnation and blood stasis type breast hyperplasia, of which 5 had accompanied by axillary lymph node enlargement.

[0043] Diagnostic criteria for patients:

[0044] The patient was confirmed to have breast hyperplasia through breast infrared scanning, breast molybdenum target X-ray, and breast color ultrasound. The diagnostic standard for qi stagnation and blood stasis syndrome of breast hyperplasia was formulated with reference to the "Guidelines for Clinical Research of New Chinese Medicines" and the "Standards for Diagnosis, Differentiation and Efficacy Evaluation of Mammary Hyperplasia" discussed and revised by the Breast Disease Professional Committee of the Chinese Society of Traditional Chinese Medicine Surgery in 2007.

[0045] ① Main symptoms: localized stabbing pain and distending pain in the breast, fixed in location; palpable lump with unclear borders and tough texture; dark purple tongue;

[0046] ② Secondary symptoms: breast pain has no obvious correlation with menstrual cycle or personal mood; irregular menstruation, abdominal distension during menstruation, menstrual period is not smooth, dark color with blood clots; pulse is stringy or astringent. Standard: diagnosis can be made with 3 main symptoms or 2 main symptoms + 2 secondary symptoms.

[0047] Exclusion criteria: patients in pregnancy and lactation, mastitis, breast malignancy, taking hormones within three months before treatment, and patients with major organ diseases of the heart, brain, kidney or liver and gallbladder system are excluded.

[0048] The above patients were all treated with the decoction prepared in Example 2 of the present invention, one bottle each time, three times a day, for continuous treatment. TCM syndrome score of observation indicators before and after treatment:

[0049] TCM syndromes include breast pain score and breast lump (size, texture) score.

[0050] (1) Breast pain score adopts the recognized visual analogue scale (VAS) pain scoring standard:

[0051] 0 points: no pain;

[0052] 1 to 3 points means mild pain, which the patient can tolerate;

[0053] 4 to 6 points: pain that affects sleep, but the patient can still tolerate it;

[0054] 7 to 10 points means the pain is gradually increasing, which is unbearable for the patient and affects appetite and sleep.

[0055] (2) Breast lump size score:

[0056] No mass was scored as 0 points;

[0057] 1 point if the long diameter of the mass is ≤1 cm;

[0058] 2 points if the long diameter of the mass is greater than 1 cm and ≤ 2 cm;

[0059] A tumor with a long diameter of >2 cm was scored as 3 points.

[0060] (3) Breast lump texture score. No lump is scored as 0 points; soft lump is scored as 1 point; firm lump is scored as 2 points; firm and hard lump is scored as 3 points.

[0061] After one month of treatment, the treatment efficacy was reviewed and statistically analyzed.

[0062] Efficacy criteria:

[0063] (1) Clinical recovery: after treatment, breast pain and breast lumps disappear, and the syndrome score is 0;

[0064] (2) Significantly effective: after treatment, the TCM syndrome score decreased by ≥70%, or the long diameter of the tumor was reduced by more than half;

[0065] (3) Effective: after treatment, the TCM syndrome score decreased by ≥30% and <70%, or the long diameter of the tumor was reduced by more than one third;

[0066] (4) Ineffective: Those who do not meet the above criteria. Effective rate = (clinical cure + marked effect + improvement) / total number of cases × 100%.

[0067] The results showed that 7 people were cured, 10 people were significantly effective, 11 people were effective, and 3 people were ineffective, with an effective rate of 90.3%.

[0068] The sexual activity level of the above patients before and after treatment was tested. Before treatment and one month after treatment, fasting venous blood was collected from the patients and centrifuged to obtain the supernatant. The supernatant was then tested for progesterone, luteinizing hormone, and estradiol levels. The test results are shown in Table 1 below:

[0069] Table 1: Serum neutral hormone levels before and after treatment ( )

[0070]

[0071] Among the 5 patients with breast hyperplasia accompanied by swollen lymph nodes, 1 was cured, 3 were significantly effective, and 1 was effective. During follow-up examinations, manual palpation and B-ultrasound examinations showed obvious improvement in their lymph node enlargement. In 2 of the patients, the symptoms of swollen lymph nodes disappeared during follow-up examinations.

[0072] Example 5: Typical Case

[0073] Case 1: Zhang, female, 38 years old, ultrasound examination, bilateral breast sections with clear layers, not thick glands, small volume, smooth and complete borders, enhanced internal echoes, disordered structure, uneven distribution, coarse light spots, and diffuse low-echo areas of varying sizes. Low-echo nodules can be seen next to the nipple at 12 o'clock on the left breast, about 7×4mm in size, regular in shape, clear in borders, uneven internal echoes, and no obvious changes in the posterior echoes. Two low-echo nodules can be seen at 9-10 o'clock on the right breast, about 5×3m and 5×3mm in size, regular in shape, clear in borders, even internal echoes, and no obvious changes in the posterior echoes. CDFI: No obvious blood flow signals were seen around and inside the nodules. No obvious enlarged lymph nodes were found in the bilateral axillae. Ultrasound suggests that the bilateral breasts show hyperplasia. The TCM diagnosis was qi stagnation and blood stasis. The decoction of Example 2 was taken, one bottle per day, and after one month of continuous treatment, the nodules were reexamined and significantly reduced in size. There was a low-echo nodule image next to the nipple at 12 o'clock on the left breast, which was approximately 3×1mm in size. There were two low-echo nodules at 9-10 o'clock on the right breast, which were approximately 2×1.5m and 2×1mm in size.

[0074] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating breast hyperplasia and lymphadenopathy, characterized in that: By weight, it consists of the following ingredients: 25-40 parts of Codonopsis pilosula, 20-30 parts of frankincense, 20-30 parts of myrrh, 15-25 parts of Illicium barometz, 10-20 parts of toon gum, 20-30 parts of safflower, 10-15 parts of Cuscuta australis, and 5-10 parts of liquorice.

2. A Chinese medicine composition for treating breast hyperplasia and lymphadenopathy according to claim 1, characterized in that: By weight, it consists of the following ingredients: 30 parts of Codonopsis pilosula, 20 parts of frankincense, 20 parts of myrrh, 15 parts of Illicium barometz, 15 parts of toon gum, 25 parts of safflower, 15 parts of Cuscuta australis, and 5 parts of liquorice.

3. A Chinese medicine composition for treating breast hyperplasia and lymphadenopathy according to claim 1, characterized in that: By weight, it consists of the following ingredients: 35 parts of Codonopsis pilosula, 20 parts of frankincense, 20 parts of myrrh, 20 parts of Illustris odoratus, 20 parts of Toona sinensis, 30 parts of Carthamus tinctorius, 15 parts of Cuscuta australis, and 5 parts of Licorice.

4. A Chinese medicine composition for treating breast hyperplasia and lymphadenopathy according to claim 1, characterized in that: By weight, it consists of the following ingredients: 25 parts of Codonopsis pilosula, 20 parts of frankincense, 20 parts of myrrh, 15 parts of Illicium barometz, 10 parts of toon gum, 20 parts of safflower, 15 parts of Cuscuta australis, and 5 parts of liquorice.

5. A Chinese medicine composition for treating breast hyperplasia and lymphadenopathy according to any one of claims 1 to 4, characterized in that: The pharmaceutical composition is added with medically acceptable adjuvants to prepare oral preparations.

6. A Chinese medicine composition for treating breast hyperplasia and lymphadenopathy according to claim 5, characterized in that: The oral preparation is one of a decoction, an oral liquid, a granule, a tablet, a capsule, and a pill.

7. A Chinese medicine composition for treating breast hyperplasia and lymphadenopathy according to claim 6, characterized in that: The preparation method of the decoction is: Take each raw material drug according to the amount, crush them separately, and mix them together; Add 20-30 times the weight of water to the mixed API, soak for 1-2 hours, boil over high heat, then simmer over low heat for 1.5-3 hours, and filter; Add 8-10 times the weight of water to the filtered residue, boil it over high heat, then simmer it over low heat for 20-40 minutes, and filter it; combine the two filtrates.

8. Use of the Chinese medicine composition according to any one of claims 1 to 4 in the preparation of medicines, characterized in that: The drug is used to treat any of the following diseases: 1) Breast hyperplasia; 2) Breast hyperplasia with enlarged axillary lymph nodes; 3) Swollen lymph nodes.

9. The use according to claim 8, characterized in that: The syndrome type of the breast hyperplasia is qi stagnation and blood stasis type.

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