Sulfonated trisaccharides, methods of making and therapeutic uses thereof
By preparing sulfonated trisaccharide compounds, the treatment challenges of multiple sclerosis, pulmonary hypertension, and inflammatory bowel disease have been solved. These compounds have been shown to improve inflammation of the nervous system, inhibit intestinal inflammation, and reduce pulmonary hypertension, exhibiting significant effects on vascular remodeling and muscle tissue formation.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- NANKAI UNIV
- Filing Date
- 2023-09-27
- Publication Date
- 2026-06-26
AI Technical Summary
There is a lack of effective drugs for treating multiple sclerosis, pulmonary hypertension and inflammatory bowel disease, especially for diseases whose etiology and pathogenesis are unclear. Furthermore, existing therapies cannot directly treat vascular remodeling and muscle tissue formation in pulmonary hypertension.
To develop a sulfonated trisaccharide compound and its salt, which is obtained by dehydroxyl protection and O-sulfonation of a fully protected trisaccharide intermediate, ultimately forming a compound with therapeutic activity for improving multiple sclerosis, inhibiting inflammatory bowel disease and reducing pulmonary hypertension.
This compound can improve neurological inflammation in multiple sclerosis, inhibit intestinal inflammation in inflammatory bowel disease, reduce cardiac hypertrophy and vascular remodeling in pulmonary hypertension, improve cardiac function, and reduce vascular muscularization.
Smart Images
Figure CN119708089B_ABST