Intraocular pressure simulation device

Abstract

The application discloses an intraocular pressure simulation device, which comprises a flow adjusting structure, a liquid containing structure, a cornea containing structure and a controller. The liquid containing structure comprises a box body and a first chamber and a second chamber enclosed by the box body, the first chamber and the second chamber are independent of each other, two pressure chambers with different pressures are formed, and the second chamber is used for containing aqueous humor simulation liquid. The first chamber and the second chamber are in communication with the flow adjusting structure. The controller is connected with the flow adjusting structure, the liquid containing structure and the cornea containing structure, so that the operation of each structure is controlled by the controller, computer software controls the intraocular pressure, and remote control is facilitated. The cornea containing structure comprises a third chamber, the third chamber is used for containing a biological cornea and is in communication with the first chamber, the aqueous humor simulation liquid is controlled to enter the anterior chamber of the biological cornea in the third chamber by the controller, and the intraocular pressure of the biological cornea with the aqueous humor simulation liquid is close to the real intraocular pressure value.

Description

TECHNICAL FIELD

[0001] The present application relates to the medical technical field, in particular to an intraocular pressure simulation device. BACKGROUND

[0002] The intraocular pressure value is an important indicator of eye health, and high intraocular pressure can cause lens opacity and iris atrophy, and severe high intraocular pressure can cause blindness. In general, the production and drainage of aqueous humor maintain a dynamic balance, that is, the amount of produced aqueous humor and the amount of drained aqueous humor are equal within a certain period of time, and if the drainage channel of aqueous humor is blocked or the amount of produced aqueous humor increases for some reason, the accumulation of aqueous humor can cause the intraocular pressure to rise, and if the amount of produced aqueous humor is too small, the accumulation of aqueous humor does not reach a certain amount, and the intraocular pressure will be too low. However, the devices on the market are difficult to directly display and simulate the intraocular pressure, and the accuracy is not high. SUMMARY

[0003] The embodiment of the present application provides an intraocular pressure simulation device, aiming to provide a biological cornea close to the real intraocular pressure value.

[0004] The first aspect embodiment of the present application provides an intraocular pressure simulation device, the intraocular pressure simulation device comprising: a flow adjusting structure; a liquid containing structure comprising a box body and a first chamber and a second chamber for containing aqueous humor simulation liquid which are enclosed by the box body and are independent of each other, the first chamber and the second chamber are in communication with the flow adjusting structure, so that the aqueous humor simulation liquid in the second chamber can flow into the first chamber through the flow adjusting structure; a cornea containing structure having a third chamber for containing a biological cornea and being in communication with the first chamber; a controller, the controller is connected with the flow adjusting structure, the liquid containing structure and the cornea containing structure, to control the aqueous humor simulation liquid in the second chamber to flow through the first chamber through the flow adjusting structure and flow into the anterior chamber of the biological cornea.

[0005] According to the embodiment of the first aspect of the present application, the flow adjusting structure comprises a flow pump, the flow pump has a liquid inlet and a liquid outlet, the liquid outlet is connected with the first chamber, and the liquid inlet is connected with the second chamber.

[0006] According to any one of the preceding embodiments of the first aspect of the present application, the first chamber is sleeved in the second chamber.

[0007] According to any one of the preceding embodiments of the first aspect of the present application, the liquid containing structure comprises a pressure relief channel and a pressure increasing channel arranged on the outer surface of the box body, the flow adjusting structure comprises a pressure relief interface and a pressure increasing interface, one end of the pressure relief channel is in communication with the second chamber, and the other end is in communication with the pressure relief interface, one end of the pressure increasing channel is in communication with the first chamber, and the other end is in communication with the pressure increasing interface.

[0008] According to any one of the foregoing embodiments of the first aspect of the application, the liquid containing structure further comprises an output pressure interface located on the outer surface of the box and in communication with the first chamber, and the cornea containing structure comprises an input pressure interface, the output pressure interface being arranged in communication with the input pressure interface.

[0009] According to any one of the foregoing embodiments of the first aspect of the application, the cornea containing structure further comprises a needle top block, one end of the input pressure interface being connected to the output pressure interface, and the other end being detachably connected to the needle top block, the needle top block being arranged in communication with the input pressure interface; and a luer needle, the luer needle being arranged in communication with the needle top block and comprising a base and a needle head fixedly arranged on the base, the base being detachably connected to one end of the needle top block away from the input pressure interface, and the third chamber being located at one end of the luer needle away from the needle top block.

[0010] According to any one of the foregoing embodiments of the first aspect of the application, the controller comprises a pressure sensor connected to the first chamber, and the liquid containing structure comprises a pressure calibration interface connected to the first chamber, the pressure calibration interface being used for mounting a pressure gauge.

[0011] According to any one of the foregoing embodiments of the first aspect of the application, the liquid containing structure further comprises a pressure relief valve arranged on the outer surface of the box, the pressure relief valve being connected to the second chamber.

[0012] According to any one of the foregoing embodiments of the first aspect of the application, the device further comprises a base having a containing groove, the liquid containing structure being arranged in the containing groove, and the base having a sliding groove formed at the bottom thereof; and a sliding block, the base being arranged on the sliding block and being in sliding connection with the sliding block.

[0013] According to any one of the foregoing embodiments of the first aspect of the application, the device further comprises a compensation motor, and a telescopic rod, one end of the telescopic rod being connected to the base and the other end being connected to the compensation motor.

[0014] According to the intraocular pressure simulation device provided in the embodiment of the present application, the intraocular pressure simulation device comprises a flow regulating structure, a liquid containing structure, a cornea containing structure and a controller. The liquid containing structure comprises a box body and a first chamber and a second chamber enclosed by the box body, the first chamber and the second chamber are independent of each other, and the first chamber and the second chamber form two pressure chambers with different pressures, the second chamber is used for containing the aqueous humor simulation liquid, and the first chamber is used for connecting the cornea containing structure and inputting the aqueous humor simulation liquid to the cornea containing structure. The first chamber and the second chamber are both in communication with the flow regulating structure, so that the aqueous humor simulation liquid in the second chamber can enter the flow regulating structure and be input into the first chamber after the flow rate is regulated by the flow regulating structure. The controller is connected with the flow regulating structure, the liquid containing structure and the cornea containing structure, so as to control the operation of each structure by the controller, realize the computer software control of the intraocular pressure, facilitate the user use and remote control. The cornea containing structure comprises a third chamber, the third chamber is used for containing a biological cornea and is in communication with the first chamber, and the aqueous humor simulation liquid is controlled to enter the anterior chamber of the biological cornea in the third chamber by the controller, so that the intraocular pressure of the biological cornea with the aqueous humor simulation liquid is close to the real intraocular pressure value. BRIEF DESCRIPTION OF DRAWINGS

[0015] Other features, objects, and advantages of the present application will become more apparent from the following detailed description of non-limiting embodiments thereof as taken in conjunction with the accompanying drawings, in which like references denote like features, and wherein:

[0016] Figure 1 is a structural schematic diagram of an intraocular pressure simulation device provided in the embodiment of the present application;

[0017] Figure 2 is Figure 1 is an exploded view of the intraocular pressure simulation device in the embodiment of the present application;

[0018] Figure 3 is an exploded view of a cornea containing structure provided in the embodiment of the present application;

[0019] Figure 4 is a partial sectional view of the cornea containing structure provided in the embodiment of the present application;

[0020] Figure 5 is a structural schematic diagram of an intraocular pressure simulation device in another embodiment;

[0021] Figure 6 is a structural schematic diagram of an intraocular pressure simulation device in still another embodiment.

[0022] BRIEF DESCRIPTION OF DRAWINGS

[0023] 10, an intraocular pressure simulation device;

[0024] 100, a flow regulating structure; 110, a pressurizing interface; 120, a pressure releasing interface;

[0025] 200, liquid containing structure; 210, first chamber; 211, pressurizing channel; 220, second chamber; 221, pressure relief channel; 230, box; 240, output pressure interface; 250, pressure calibration interface; 260, pressure relief valve;

[0026] 300, cornea containing structure; 310, third chamber; 320, input pressure interface; 330, needle tip block; 340, luer needle; 341, base; 342, needle tip;

[0027] 400, controller; 410, pressure sensor;

[0028] 500, base; 510, sliding slot; 520, sealing gasket;

[0029] 600, sliding block;

[0030] 700, compensation motor;

[0031] 800, telescopic rod. DETAILED DESCRIPTION

[0032] The features and exemplary embodiments of various aspects of the present application will be described below in detail, in order to make the purposes, technical solutions and advantages of the present application more clear and apparent, the present application will be further described in detail below in combination with the drawings and specific embodiments. It should be understood that the specific embodiments described herein are only configured to explain the present application, and are not configured to limit the present application. The present application can be implemented without some of these specific details for those skilled in the art. The following description of the embodiments is only to provide a better understanding of the present application by showing examples of the present application.

[0033] It should be noted that, in this paper, relationship terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between the entities or operations. Moreover, the terms "include", "contain" or any other variant thereof are intended to cover non-exclusive inclusion, so that the process, method, article or equipment including a series of elements not only includes those elements, but also includes other elements not explicitly listed, or includes elements inherent in such process, method, article or equipment. Without more limitations, the elements defined by the statement "include" do not exclude the presence of other identical elements in the process, method, article or equipment including the elements.

[0034] It should be understood that when describing the structure of a component, when a layer, a region is referred to as being located on or above another layer, another region, it can be directly located on or above another layer, another region, or other layers or regions are also included between it and another layer, another region. And if the component is turned over, the layer, the region will be located below or below another layer, another region.

[0035] Embodiments of the present application provide an intraocular pressure simulation device, which will be described below in combination with the drawings.

[0036] Please refer to Figure 1 and Figure 2 , Figure 1 is a structural schematic diagram of an intraocular pressure simulation device provided by embodiments of the present application; Figure 2 is Figure 1 an exploded view of the intraocular pressure simulation device in

[0037] As shown in Figure 1 and Figure 2 , the first aspect of the present application provides an intraocular pressure simulation device 10, which comprises a flow regulating structure 100, a liquid containing structure 200, a cornea containing structure 300 and a controller 400; the liquid containing structure 200 comprises a box body 230 and a first chamber 210 and a second chamber 220 for containing aqueous humor simulation liquid, which are enclosed by the box body 230 and are independent of each other, the first chamber 210 and the second chamber 220 are both in communication with the flow regulating structure 100, so that the aqueous humor simulation liquid in the second chamber 220 can flow into the first chamber 210 through the flow regulating structure 100; the cornea containing structure 300 has a third chamber 310 for containing biological cornea and in communication with the first chamber 210; the controller 400 is connected with the flow regulating structure 100, the liquid containing structure 200 and the cornea containing structure 300, so as to control the aqueous humor simulation liquid in the second chamber 220 to flow through the first chamber 210 and into the anterior chamber of the biological cornea through the flow regulating structure 100.

[0038] According to the intraocular pressure simulation device 10 of the embodiment of the present application, the intraocular pressure simulation device 10 comprises a flow rate adjusting structure 100, a liquid containing structure 200, a cornea containing structure 300 and a controller 400. The liquid containing structure 200 comprises a box 230 and a first chamber 210 and a second chamber 220 enclosed by the box 230, the first chamber 210 and the second chamber 220 are independent of each other, forming two pressure chambers with different pressures, the second chamber 220 is used for containing aqueous humor simulation liquid, and the first chamber 210 is used for connecting the cornea containing structure 300 and inputting the aqueous humor simulation liquid to the cornea containing structure 300. The first chamber 210 and the second chamber 220 are both in communication with the flow rate adjusting structure 100, so that the aqueous humor simulation liquid in the second chamber 220 can enter the flow rate adjusting structure 100 and be inputted into the first chamber 210 after being adjusted in flow rate by the flow rate adjusting structure 100. The controller 400 is connected with the flow rate adjusting structure 100, the liquid containing structure 200 and the cornea containing structure 300, so as to control the operation of each structure by the controller 400, realize computer software control of intraocular pressure, facilitate user use and remote control. The cornea containing structure 300 comprises a third chamber 310, the third chamber 310 is used for containing a biological cornea and is in communication with the first chamber 210, and the aqueous humor simulation liquid is controlled to enter the anterior chamber of the biological cornea in the third chamber 310 by the controller 400, so that the intraocular pressure of the biological cornea with the aqueous humor simulation liquid is close to the real intraocular pressure value.

[0039] Optionally, the aqueous humor simulation liquid comprises a 1:1 mixed solution of physiological saline and ascorbic acid hydrogen peroxide, so as to ensure the freshness of the biological cornea.

[0040] Optionally, the controller 400 adopts a metal sealed structure, so as to reduce electromagnetic interference and crosstalk signals.

[0041] Optionally, the biological cornea comprises a pig cornea or a polydimethylsiloxane (PDMS) film.

[0042] In some optional embodiments, the flow rate adjusting structure 100 comprises a flow pump, the flow pump has a liquid inlet and a liquid outlet, the liquid outlet is connected with the first chamber 210, and the liquid inlet is connected with the second chamber 220.

[0043] In these optional embodiments, the flow pump is used for adjusting the flow rate of the liquid, the liquid inlet of the flow pump is connected with the second chamber 220, so that the aqueous humor simulation liquid in the second chamber 220 can enter the flow pump through the liquid inlet, and then the aqueous humor simulation liquid enters the first chamber 210 connected with the liquid outlet after being adjusted in flow rate.

[0044] Optionally, the flow rate of the flow pump comprises 3 μl / min, and the flow rate of 3 μl / min meets the normal aqueous humor production amount, so as to provide accurate pressure control for simulating intraocular pressure.

[0045] Optionally, the flow pump comprises a micro flow pump to provide precise pressure control for the simulation of intraocular pressure.

[0046] In some optional embodiments, the first chamber 210 is sleeved in the second chamber 220.

[0047] In these optional embodiments, the first chamber 210 is sleeved in the second chamber 220 means that the second chamber 220 is arranged around the first chamber 210, and the two are sleeved with each other, so that the first chamber 210 is located in the second chamber 220 and the first chamber 210 and the second chamber 220 are independent of each other and have different pressures.

[0048] As shown in Figure 3 In some optional embodiments, the liquid containing structure 200 comprises a pressure relief channel 221 and a pressure increasing channel 211 arranged on the outer surface of the box 230, and the flow regulating structure 100 comprises a pressure relief interface 120 and a pressure increasing interface 110, one end of the pressure relief channel 221 is in communication with the second chamber 220, and the other end is in communication with the pressure relief interface 120, one end of the pressure increasing channel 211 is in communication with the first chamber 210, and the other end is in communication with the pressure increasing interface 110.

[0049] In these optional embodiments, the pressure relief channel 221 communicates the pressure relief interface 120 of the flow regulating structure 100 with the second chamber 220, so that the aqueous humor simulation liquid in the second chamber 220 can enter the pressure relief interface 120 through the pressure relief channel 221 and be flow rate regulated by the flow regulating structure 100. The pressure increasing channel 211 communicates the pressure increasing interface 110 of the flow regulating structure 100 with the first chamber 210, so that the pressurized aqueous humor simulation liquid can flow through the pressure increasing interface 110, flow through the pressure increasing channel 211, and enter the first chamber 210, so as to enter the biological corneal anterior chamber of the third chamber 310 through the first chamber 210, to provide a biological cornea close to the true intraocular pressure.

[0050] In some optional embodiments, the liquid containing structure 200 further comprises an output pressure interface 240 located on the outer surface of the box 230 and in communication with the first chamber 210, and the corneal containing structure 300 comprises an input pressure interface 320, and the output pressure interface 240 is arranged in communication with the input pressure interface 320.

[0051] In these optional embodiments, the first chamber 210 is in communication with the input pressure interface 320 of the corneal containing structure 300 through the output pressure interface 240, so that the pressurized aqueous humor simulation liquid can enter the corneal containing structure 300 through the first chamber 210, i.e. enter the biological corneal anterior chamber of the third chamber 310, to provide a biological cornea close to the true intraocular pressure.

[0052] As shown in Figure 2As shown, in some optional embodiments, the controller 400 includes a pressure sensor 410, which is connected to the first chamber 210, and the liquid containing structure 200 includes a pressure calibration interface 250 connected to the first chamber 210, and the pressure calibration interface 250 is used to install a pressure gauge.

[0053] In these optional embodiments, the pressure sensor 410 of the controller 400 is connected to the first chamber 210 to monitor the pressure within the first chamber 210. Furthermore, the liquid containment structure 200 is provided with a pressure calibration interface 250 connected to the first chamber 210. The pressure calibration interface 250 is used to connect an external pressure gauge to calibrate the pressure sensor 410, thereby enabling computer software to control intraocular pressure, facilitating user use and remote control. The pressure gauge can be a high-precision pressure gauge, such as a YB-1 pressure gauge, which performs high-precision calibration of the pressure within the first chamber 210 to control the pressure of the first chamber 210 within a range of 0 to 120 mmHg.

[0054] Please also refer to Figure 3 and Figure 4 , Figure 3 This is an exploded view of a cornea accommodation structure provided in an embodiment of the present application; Figure 4 This is a partial cross-sectional view of a corneal accommodation structure provided in an embodiment of the present application.

[0055] like Figure 3 and Figure 4 As shown, in some optional embodiments, the cornea accommodation structure 300 further includes a needle ejector block 330 and a Luer needle 340. The input pressure interface 320 is connected to the output pressure interface 240 at one end and detachably connected to the needle ejector block 330 at the other end. The needle ejector block 330 is in communication with the input pressure interface 320. The Luer needle 340 is in communication with the needle ejector block 330 and includes a base 341 and a needle head 342 fixed to the base 341. The base 341 is detachably connected to the end of the needle ejector block 330 away from the input pressure interface 320. The third chamber 310 is located at the end of the Luer needle 340 away from the needle ejector block 330.

[0056] In these optional embodiments, the input pressure interface 320 connects the output pressure interface 240 to the needle ejection block 330. Simulated aqueous humor enters the corneal accommodation structure 300 through the input pressure interface 320 and flows sequentially through the needle ejection block 330 and the Luer needle 340. The needle tip 342 of the Luer needle 340 can directly penetrate the anterior chamber of the biological cornea located within the third chamber 310. The input pressure interface 320 directly generates a comprehensive injection pressure, and the simulated aqueous humor is injected into the anterior chamber of the biological cornea through the Luer needle 340, simulating the ciliary muscle to generate aqueous humor flowing into the anterior chamber, thereby bringing the intraocular pressure of the biological cornea closer to the actual intraocular pressure.

[0057] See also Figure 5, Figure 5 Schematic diagram of the structure of an intraocular pressure simulation device in another embodiment.

[0058] like Figure 5 As shown, in some optional embodiments, the liquid containing structure 200 further includes a pressure relief valve 260 disposed on the outer surface of the box body 230 , and the pressure relief valve 260 is connected to the second chamber 220 .

[0059] In these optional embodiments, the second chamber 220 is connected to a pressure relief valve 260 to prevent negative pressure from forming in the second chamber 220 and affecting the flow rate of the flow regulating structure 100, thereby ensuring that the flow regulating structure 100 can normally regulate the flow rate of the aqueous humor simulated fluid.

[0060] Optionally, there are multiple pressure relief valves 260, and the multiple pressure relief valves 260 are distributed at intervals on the outer surface of the box body 230 to improve the pressure relief efficiency.

[0061] See also Figure 6 , Figure 6 3 is a structural diagram of an intraocular pressure simulation device in another embodiment.

[0062] like Figure 6 As shown, in some optional embodiments, the intraocular pressure simulation device 10 also includes a base 500 and a slider 600, the base 500 has a receiving groove, the liquid receiving structure 200 is arranged in the receiving groove, and a slide groove 510 is opened at the bottom of the base 500; the base 500 is arranged on the slider 600 and is slidably connected to the slider 600.

[0063] In these optional embodiments, the base 500 is provided with a receiving groove for accommodating the liquid containing structure 200, which not only supports the liquid containing structure 200 but also protects it. The bottom of the base 500 refers to the side of the base 500 facing away from the receiving groove. The base 500 is provided with a slide groove 510, which allows the slide groove 510 to slide on the slider 600. When intraocular pressure increases, the eyeball will protrude significantly. At this time, the liquid containing structure 200 can slide to correct the error caused by the increased intraocular pressure and ensure the accuracy of the intraocular pressure measurement.

[0064] Optionally, a sealing gasket 520 is provided between the base 500 and the liquid containing structure 200 to ensure the sealing of the liquid containing structure 200 and prevent liquid leakage.

[0065] In some optional embodiments, the intraocular pressure simulation device 10 further includes a compensation motor 700 and a telescopic rod 800 ; one end of the telescopic rod 800 is connected to the base 500 , and the other end is connected to the compensation motor 700 .

[0066] In these optional embodiments, the telescopic rod 800 connects the compensation motor 700 and the base 500, and when the intraocular pressure rises, the liquid containing structure 200 slides on the slider 600 through the telescopic movement of the telescopic rod 800 to correct the error of the intraocular pressure rise, ensuring the accuracy of the intraocular pressure. The compensation motor 700 can more accurately control the displacement of the telescopic rod 800, improve the accuracy of the displacement, and ensure the effect of correcting the error. For example, when the intraocular pressure rises, the eyeball protrudes about 2 mm, and the telescopic rod 800 corrects 2 mm.

[0067] Therefore, the biological corneal intraocular pressure provided by the intraocular pressure simulation device 10 of the present application is close to the real intraocular pressure. It meets the actual needs.

[0068] According to the embodiments of the present application described above, these embodiments do not describe all the details and do not limit the application to the specific embodiments described. Obviously, many modifications and variations can be made according to the above description. The present description selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present application, so that those skilled in the art can well utilize the present application and make modifications and uses on the basis of the present application. The present application is limited only by the claims and their full scope and equivalents.

Claims

1. An intraocular pressure simulation device, comprising: The intraocular pressure simulation device comprises: a flow regulating structure; a liquid containing structure comprising a box and a first chamber and a second chamber for containing aqueous humor simulation liquid enclosed by the box and independent of each other, the first chamber and the second chamber being in communication with the flow regulating structure so that the aqueous humor simulation liquid in the second chamber can flow into the first chamber through the flow regulating structure; a cornea containing structure having a third chamber for containing a biological cornea and being in communication with the first chamber; a controller connected to the flow regulating structure, the liquid containing structure and the cornea containing structure to control the aqueous humor simulation liquid in the second chamber to flow through the first chamber and into the anterior chamber of the biological cornea through the flow regulating structure; the liquid containing structure further comprises an output pressure interface on the outer surface of the box and in communication with the first chamber, and the cornea containing structure comprises an input pressure interface, the output pressure interface being in communication with the input pressure interface; the cornea containing structure further comprises: a needle top block, one end of the input pressure interface being connected to the output pressure interface, and the other end being detachably connected to the needle top block, the needle top block being in communication with the input pressure interface; a luer needle, the luer needle being in communication with the needle top block and comprising a base and a needle head fixedly arranged on the base, the base being detachably connected to the end of the needle top block away from the input pressure interface, and the third chamber being located at the end of the luer needle away from the needle top block.

2. The ocular pressure simulation device of claim 1, wherein, The flow regulating structure comprises a flow pump having a liquid inlet and a liquid outlet, the liquid outlet being connected to the first chamber, and the liquid inlet being connected to the second chamber.

3. The ocular pressure simulation device of claim 1, wherein, The first chamber is sleeved in the second chamber.

4. The ocular pressure simulation device of claim 1, wherein, The liquid containing structure comprises a pressure relief channel and a pressure increasing channel arranged on the outer surface of the box, the flow regulating structure comprises a pressure relief interface and a pressure increasing interface, one end of the pressure relief channel being in communication with the second chamber and the other end being in communication with the pressure relief interface, and one end of the pressure increasing channel being in communication with the first chamber and the other end being in communication with the pressure increasing interface.

5. The intraocular pressure analog device of claim 1, wherein, The controller comprises a pressure sensor connected to the first chamber, and the liquid containing structure comprises a pressure calibration interface connected to the first chamber, the pressure calibration interface being used for installing a pressure gauge.

6. The intraocular pressure analog device of claim 1, wherein, The liquid containing structure further comprises a pressure relief valve arranged on the outer surface of the box, the pressure relief valve being connected to the second chamber.

7. The ocular pressure simulation device of claim 1, wherein, Further comprising: a base having a containing groove, the liquid containing structure being arranged in the containing groove, and a sliding groove being formed at the bottom of the base; a sliding block, the base being arranged on the sliding block and being in sliding connection with the sliding block.

8. The ocular pressure simulation device of claim 7, wherein, Further comprising: a compensation motor; a telescopic rod, one end of the telescopic rod being connected to the base and the other end being connected to the compensation motor.

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