Ablation control method, system and device, computer equipment and storage medium

Abstract

The invention relates to an ablation control method, system and device, computer equipment, a computer readable storage medium and a computer program product. The method includes providing an ablation signal to a target electrode to apply ablation energy to an ablation region in a case where the ablation region is determined. Within a preset time period after the ablation energy is applied to the ablation area, continuously obtaining cardiac displacement parameters of an acting object of the target electrode; under the condition that the cardiac discharge volume parameter is not increased relative to a preset reference threshold value, an electrical stimulation signal is provided for the target electrode so as to apply stimulation energy to the ablation area and obtain an electrocardiosignal of an acting object of the target electrode, and the stimulation energy is used for activating sympathetic nerves in the ablation area; according to the electrocardiosignal, the ablation result of the ablation area is determined, and the ablation result comprises one of effective ablation and invalid ablation. And the ablation result is accurately determined by combining the electrocardiosignal and the cardiac discharge volume.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and in particular to an ablation control method, system, device, computer equipment, computer-readable storage medium, and computer program product. Background Art

[0002] With the development of medical technology, minimally invasive ablation technology has emerged. A small incision is made in the epidermis of the subject, and then an electrode needle is inserted into the subject's body to reach the location of the subject's lesion tissue. Then, the lesion tissue of the subject is ablated by the high-voltage pulse generated between the electrodes, thereby achieving the purpose of removing the lesion tissue of the subject. Pulmonary hypertension (PH) refers to a clinical and pathophysiological syndrome caused by changes in the structure or function of the pulmonary vascular due to a variety of heterogeneous diseases (causes) and different pathogenesis, which causes pulmonary vascular resistance and pulmonary artery pressure to increase. The progressive increase in pulmonary artery pressure leads to changes in the patient's cardiopulmonary circulation hemodynamics, pulmonary artery vascular remodeling, right heart hypertrophy, functional failure, and then develops into right heart failure and even death. At present, the treatment of pulmonary hypertension revolves around three main pathways related to endothelial dysfunction responsible for pulmonary artery remodeling. This includes inhibiting vasoconstrictors and activating major vasodilators, such as nitric oxide and prostacyclin. Despite the widespread use of pulmonary hypertension-specific treatments, the mortality rate of patients remains high, accounting for about 10% of patients each year, and the 5-year survival rate is still unacceptably low (59.4%). Studies have shown that increased sympathetic nerve activity is associated with the pathogenesis of pulmonary hypertension. Rudner et al. reported that sympathetic nerves exist in the pulmonary artery wall and participate in the regulation of pulmonary artery pressure, suggesting that perivascular nerves are potential targets for interventional therapy. Therefore, pulmonary artery dialysis (PADN) has been proposed as a method to reduce pulmonary artery pressure. Some people have already practiced this method in animals and humans. In these studies, a decrease in pulmonary artery pressure was recorded after circular ablation of the pulmonary artery bifurcation and the proximal part of the left and right main pulmonary arteries. Published clinical studies have shown that pulmonary artery pressure was significantly reduced after non-selective circular pulmonary artery ablation. Non-selective circular pulmonary artery ablation is a blind ablation that ignores the distribution of sympathetic nerves on the pulmonary artery adventitia, which may further lead to pulmonary artery fibrosis remodeling and loss of pulmonary artery dilatation capacity, which is associated with further development of pulmonary hypertension and death.

[0003] In traditional technology, doctors rely on their own experience to operate electrodes to perform ablation surgery on the target lesion tissue. Whether it is non-selective circular ablation of the pulmonary artery (blind ablation) or ablation by stimulating the mapping target, the treatment effect can often only be followed up, and it is impossible to know in real time whether the ablation has killed the sympathetic nerves. The decrease in impedance during ablation can only prove that the vascular epithelial cells have been killed, but the nerves are often buried deep, and the decrease in impedance cannot be used to determine whether the nerves have been killed. In other words, during the ablation process, it is impossible to determine whether the sympathetic nerves at the ablation point have been killed. Once there are too many ineffective ablations, it will directly affect the surgical effect, and postoperative recurrence is also prone to occur. Therefore, there may be incomplete ablation or ablation failure. How to intuitively judge whether the sympathetic nerves at the ablation point exist and have been killed, and then determine whether ablation needs to continue, and determine the effect of ablation, so as to improve the surgical effect, is a problem that needs to be solved at present. Summary of the invention

[0004] Based on this, it is necessary to provide an ablation control method, system, device, computer equipment, computer-readable storage medium, and computer program product that can detect the ablation effect and accurately determine whether the ablation is effective in response to the above technical problems.

[0005] An ablation control method, comprising:

[0006] When the ablation area is determined, providing an ablation signal to the target electrode to apply ablation energy to the ablation area, wherein the ablation energy is used to clear the sympathetic nerves in the ablation area;

[0007] within a preset time period after ablation energy is applied to the ablation region, continuously acquiring a cardiac output parameter of a subject to which the target electrode is applied;

[0008] When the cardiac output parameter does not increase relative to a preset reference threshold, providing an electrical stimulation signal to the target electrode to apply stimulation energy to the ablation region and obtain an electrocardiogram signal of a subject of the target electrode, wherein the stimulation energy is used to activate sympathetic nerves in the ablation region;

[0009] The ablation result of the ablation area is determined according to the electrocardiogram signal, wherein the ablation result includes one of effective ablation and ineffective ablation.

[0010] In one of the embodiments, the ablation control method further comprises: when the cardiac output parameter increases relative to the preset reference threshold, determining that the ablation result of the ablation area is effective ablation.

[0011] In one of the embodiments, the cardiac output parameters of the target electrode's target object are continuously obtained within a preset time period after ablation energy is applied to the ablation area, including: heating a preset area to be heated of the target object within a preset time period after ablation energy is applied to the ablation area, and obtaining temperature parameters of a preset temperature monitoring area; determining the cardiac output parameters of the target object within the preset time period based on the temperature parameters within the preset time period.

[0012] In one of the embodiments, determining the ablation result of the ablation area based on the ECG signal includes: determining the ablation category corresponding to the ablation area based on the change trend of the ECG signal and a preset ECG range, wherein the ablation category includes a recommended ablation category and a no-ablation-needed category; when it is determined that the ablation category corresponding to the ablation area is a no-ablation-needed category, determining that the ablation result of the ablation area is effective ablation; when it is determined that the ablation category corresponding to the ablation area is a recommended ablation category, determining that the ablation result of the ablation area is invalid ablation.

[0013] In one of the embodiments, determining the ablation category corresponding to the ablation area based on the change trend of the ECG signal and a preset ECG threshold includes: converting the type of the ECG signal into a frequency domain signal to obtain a frequency domain ECG signal; determining the change rate of the frequency domain ECG signal based on the frequency domain ECG signal and a preset reference frequency domain ECG signal; determining the ablation area as a category that does not require ablation when the change rate of the frequency domain ECG signal is within the preset ECG range; and determining the ablation area as a recommended ablation category when the change rate of the frequency domain ECG signal is outside the preset ECG range.

[0014] In one of the embodiments, the ablation control method further includes: when the amplitude of the frequency domain ECG signal is greater than a first threshold, issuing a warning signal; when the amplitude of the frequency domain ECG signal is greater than a second threshold, stopping providing the electrical stimulation signal to the target electrode, wherein the second threshold is greater than the first threshold.

[0015] In one of the embodiments, the ablation control method further includes: when it is determined that the ablation result of the ablation area is invalid ablation, jumping to the step of providing an ablation signal to the target electrode to apply ablation energy to the ablation area.

[0016] In one of the embodiments, when the ablation area is determined, before the step of providing an ablation signal to the target electrode, the ablation control method also includes: providing an electrical stimulation signal to at least one electrode; in the process of providing the electrical stimulation signal to at least one of the electrodes, acquiring an electrocardiogram signal of an object of action of at least one of the electrodes; determining whether the stimulation area corresponding to the current electrode is the ablation area based on the electrocardiogram signal, wherein when the stimulation area corresponding to the current electrode is the ablation area, the current electrode serves as the target electrode.

[0017] An ablation system, comprising:

[0018] An electrode assembly, comprising a catheter and a plurality of electrodes spaced apart on the catheter;

[0019] an ablation module, connected to the plurality of electrodes respectively, and used for providing an ablation signal to each of the electrodes, wherein after receiving the ablation signal, the electrode outputs an ablation energy for clearing the sympathetic nerves;

[0020] a stimulation module, connected to the plurality of electrodes respectively, and used for providing an electrical stimulation signal to each of the electrodes, wherein after receiving the ablation signal, the electrode outputs stimulation energy for activating the sympathetic nerve;

[0021] A collection module, used for collecting cardiac output parameters and electrocardiogram signals of the subject to which the multiple electrodes act;

[0022] The control module is connected to the ablation module, the stimulation module and the acquisition module respectively, and is used to control the ablation module to provide an ablation signal to the target electrode so as to apply ablation energy to the ablation area when the ablation area is determined; continuously obtain the cardiac output parameter of the target electrode within a preset time period after the ablation energy is applied to the ablation area; when the cardiac output parameter does not increase relative to a preset reference threshold, control the stimulation module to provide an electrical stimulation signal to the target electrode so as to apply stimulation energy to the ablation area and obtain the electrocardiogram signal of the target electrode; determine the ablation result of the ablation area according to the electrocardiogram signal, wherein the ablation result includes one of effective ablation and ineffective ablation.

[0023] In one embodiment, the acquisition module includes: a thermistor guide wire, which is arranged on the catheter; a temperature sensing assembly, which is arranged on the catheter; a heart rate acquisition unit, which is connected to an external heart rate measuring device and is used to obtain the electrocardiogram signal measured by the heart rate measuring device; the control module is respectively connected to the thermistor guide wire, the temperature sensing assembly, and the heart rate acquisition unit, and is used to provide a pulse signal to the thermistor guide wire so that the thermistor guide wire heats a preset area to be heated, and obtains the temperature parameters of the preset temperature monitoring area through the temperature sensing assembly, determines the cardiac output parameters of the object within the preset time period according to the temperature parameters within the preset time period, and obtains the electrocardiogram signal through the heart rate acquisition unit.

[0024] An ablation control device, comprising:

[0025] an ablation module, configured to provide an ablation signal to a target electrode when an ablation region is determined, so as to apply ablation energy to the ablation region, wherein the ablation energy is used to clear sympathetic nerves in the ablation region;

[0026] A cardiac output acquisition module, used for continuously acquiring cardiac output parameters of the target electrode's target object within a preset time period after ablation energy is applied to the ablation area;

[0027] a stimulation module, configured to provide an electrical stimulation signal to the target electrode when the cardiac output parameter does not increase relative to a preset reference threshold value, so as to apply stimulation energy to the ablation area and obtain an electrocardiogram signal of an object of the target electrode, wherein the stimulation energy is used to activate sympathetic nerves in the ablation area;

[0028] The result determination module is used to determine the ablation result of the ablation area according to the electrocardiogram signal, wherein the ablation result includes one of effective ablation and ineffective ablation.

[0029] In one embodiment, a computer device is provided, including a memory and a processor, wherein the memory stores a computer program, and the processor implements the aforementioned ablation control method when executing the computer program.

[0030] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored. When the computer program is executed by a processor, the ablation control method described above is implemented.

[0031] In one of the embodiments, a computer program product is provided, wherein the computer program product comprises a computer program, and when the computer program is executed by a processor, the ablation control method described above is implemented.

[0032] The above-mentioned ablation control method, system, device, computer equipment, computer-readable storage medium, and computer program product. The ablation control method first provides an ablation signal to the target electrode when the ablation area is determined, so that the target electrode releases ablation energy to the ablation area, and can ablate the sympathetic nerves to be ablated in the ablation area, which is beneficial to the patient. Then, within a preset time period after the ablation energy is applied to the ablation area, the cardiac output parameters of the target electrode's target are continuously obtained, so that the effect of ablation can be judged by the cardiac output parameters later. Then, when the cardiac output parameter has not increased relative to the preset benchmark threshold, it can be preliminarily judged that the result of ablation is ineffective ablation. However, in order to ensure the accuracy of the judgment, it is necessary to combine the judgment with the ECG signal, so an electrical stimulation signal is provided to the target electrode to activate the sympathetic nerves in the ablation area, so as to apply stimulation energy to the ablation area and obtain the ECG signal of the target electrode's target, and then determine the ablation result of the ablation area based on the ECG signal. Therefore, this scheme makes a preliminary judgment on the ablation result through the cardiac output parameter, and then further judges the ablation result through the ECG signal. By combining the cardiac output parameter and the ECG signal, the accuracy of the ablation result judgment is improved, and the ablation result can be accurately determined, which is convenient for doctors to accurately grasp the specific circumstances of ablation and improve the surgical effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the conventional technology, the drawings required for use in the embodiments or the conventional technology descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0034] Figure 1 is a schematic flow chart of an ablation control method in one embodiment;

[0035] Figure 2 is a flow chart of an ablation control method in another embodiment;

[0036] Figure 3 A schematic flow chart of a method for obtaining cardiac output in one embodiment;

[0037] Figure 4 A schematic diagram of a flow chart of a method for determining an ablation result in one embodiment;

[0038] Figure 5 A schematic flow chart of a method for determining an ablation category in one embodiment;

[0039] Figure 6 is a waveform diagram of a frequency domain electrocardiogram signal in an embodiment;

[0040] Figure 7 is a waveform diagram of a frequency domain electrocardiogram signal in another embodiment;

[0041] Figure 8 is a waveform diagram of a frequency domain electrocardiogram signal in yet another embodiment;

[0042] Fig. 9 The second waveform diagram of the frequency domain ECG signal in yet another embodiment;

[0043] Fig.10 A local waveform diagram of a frequency domain electrocardiogram signal in an embodiment;

[0044] Fig.11 The third waveform diagram of the frequency domain ECG signal in yet another embodiment;

[0045] Fig.12 is a local waveform diagram of a frequency domain electrocardiogram signal in another embodiment;

[0046] Fig.13 A schematic diagram of a flow chart of a method for protecting an object in one embodiment;

[0047] Fig.14 The second flowchart of the ablation control method in another embodiment;

[0048] Fig.15 The third flowchart of the ablation control method in another embodiment;

[0049] Fig.16 is a schematic structural diagram of an ablation system in one embodiment;

[0050] Fig.17 is a schematic structural diagram of an ablation system in another embodiment;

[0051] Fig.18 is a schematic diagram of the structure of a catheter in one embodiment;

[0052] Fig.19 is a schematic structural diagram of an ablation system in yet another embodiment;

[0053] Fig. 20 is a schematic structural diagram of an ablation control device in one embodiment;

[0054] Fig.21 FIG. 4 is a diagram showing the internal structure of a computer device in one embodiment.

[0055] Description of reference numerals:

[0056] 10-catheter, 20-electrode, 30-ablation module, 40-stimulation module, 50-acquisition module, 60-control module, 51-thermosensitive guide wire, 52-temperature sensing component, 53-heart rate acquisition unit, 70-neutral electrode, 54-infusion hole. DETAILED DESCRIPTION

[0057] In order to facilitate understanding of the present application, the present application will be described more fully below with reference to the relevant drawings. Embodiments of the present application are provided in the drawings. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present application more thorough and comprehensive.

[0058] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0059] It can be understood that the terms "first", "second", etc. used in the present application can be used in this article to describe various elements, but these elements are not limited by these terms. These terms are only used to distinguish the first element from another element.

[0060] Spatially relative terms such as "under," "beneath," "below," "under," "above," "above," and the like may be used herein to describe the relationship of an element or feature shown in the figures to other elements or features. It should be understood that, in addition to the orientations shown in the figures, spatially relative terms also include different orientations of the device in use and operation. For example, if the device in the accompanying drawings is flipped, an element or feature described as "under other elements" or "under it" or "under it" will be oriented as being "above" the other elements or features. Thus, the exemplary terms "under" and "under" may include both upper and lower orientations. In addition, the device may also include additional orientations (e.g., rotated 90 degrees or other orientations), and the spatial descriptors used herein are interpreted accordingly.

[0061] It should be noted that when an element is considered to be "connected" to another element, it can be directly connected to the other element, or connected to the other element through an intermediate element. In addition, the "connection" in the following embodiments should be understood as "electrical connection", "communication connection", etc. if there is transmission of electrical signals or data between the connected objects.

[0062] When used herein, the singular forms "a", "an", and "said / the" may also include plural forms, unless the context clearly indicates otherwise. It should also be understood that the terms "include / comprise" or "have" etc. specify the presence of stated features, wholes, steps, operations, components, parts or combinations thereof, but do not exclude the possibility of the presence or addition of one or more other features, wholes, steps, operations, components, parts or combinations thereof.

[0063] In one embodiment, Figure 1 As shown, an ablation control method is provided, which includes: steps S100-S130.

[0064] Step S100 , when the ablation area is determined, an ablation signal is provided to the target electrode to apply ablation energy to the ablation area.

[0065] The ablation energy is used to remove the sympathetic nerves in the ablation area.

[0066] Among them, the ablation area is determined in advance, and the position of the ablation area can be determined according to the physiological parameters of the subject (such as heart rate, blood pressure, etc.) when the electrode releases the electrical stimulation signal. The position of the ablation area can also be determined by endoscopy, or by magnetic resonance imaging or electronic computed tomography.

[0067] The target electrode is an electrode whose action range covers at least a part of the ablation area. When the target electrode releases ablation energy, at least a part of the ablation area can be ablated. The ablation signal can be high-power ablation energy, and its unit is watt. High-power ablation energy refers to energy that can cause destructive damage to cells in a specific part and cause them to die when acting on a specific part. Exemplarily, the output power of the ablation energy can be 0-40W, which is adjusted as needed.

[0068] Step S110, continuously acquiring cardiac output parameters of the subject to which the target electrode is applied within a preset time period after the ablation energy is applied to the ablation area.

[0069] Specifically, cardiac output (CO) is an important predictor of the effect of pulmonary hypertension ablation. By blocking the sympathetic nerves around the pulmonary artery, the pulmonary artery pressure can be reduced, the right heart state can be improved, and the cardiac output can be increased, so the cardiac output will increase. By continuously acquiring the cardiac output parameters of the target electrode's target, a continuous cardiac output (CCO) test can be performed. By comparing the CCO before and after sympathetic nerve ablation, an increase in CCO indicates that the ablation is effective, and no change indicates that the ablation may be ineffective or the nerve damage is not deep enough.

[0070] For example, the cardiac output of the subject may be continuously measured within 5 to 10 minutes after ablation energy is applied to the ablation region.

[0071] Step S120, when the cardiac output parameter has not increased relative to the preset reference threshold, providing an electrical stimulation signal to the target electrode to apply stimulation energy to the ablation area and obtain an electrocardiogram signal of the target electrode's subject.

[0072] Therein, stimulation energy is used to activate sympathetic nerves within the ablation area.

[0073] Among them, the preset reference threshold can be the cardiac output parameter of the target electrode's target object measured before stimulation energy or ablation energy is applied (i.e. before any energy is applied), that is, the initial cardiac output parameter of the target object, as the preset reference threshold.

[0074] Specifically, when the cardiac output parameter has not increased relative to the preset benchmark threshold, it means that the ablation of the ablation area may be ineffective, or the ablation effect may be insufficient, or there may be other reasons. Therefore, it is necessary to apply stimulation energy to the ablation area and obtain the ECG signal of the target electrode's target object for further judgment.

[0075] Specifically, the energy of the electrical stimulation signal is relatively small, usually at the milliampere level, and can be used to electrically stimulate a specific part in the form of a pulse wave. When the stimulation energy acts on a specific part, it will not cause damage to the cells in the specific part, but will cause changes in the physiological parameters of the target object. Specifically, when the electrical stimulation signal acts on the pulmonary artery sympathetic nerve, the physiological parameters of the target object will change significantly, while when the electrical stimulation signal does not act on the pulmonary artery sympathetic nerve, the changes in the physiological parameters of the target object are not obvious.

[0076] Exemplarily, a current of 0-30 mA or a voltage of 0-15 V may be output, and the output current or voltage may be in the form of pulse energy with a frequency of 0.5-40 Hz and a pulse width of 0.5, 1, or 2 milliseconds as an electrical stimulation signal.

[0077] Step S130, determining the ablation result of the ablation area according to the electrocardiogram signal.

[0078] The ablation result includes one of effective ablation and ineffective ablation.

[0079] Specifically, after the sympathetic nerves are stimulated by signals, they will cause significant changes in the subject's ECG signals. If there are no sympathetic nerves in the ablation area, such changes will not occur. Therefore, the ECG signals can be used to determine whether sympathetic nerves still exist in the ablation area, and then the ablation effect of the ablation area can be determined.

[0080] In this embodiment, first, when the ablation area is determined, an ablation signal is provided to the target electrode, so that the target electrode releases ablation energy to the ablation area, and the sympathetic nerves to be ablated in the ablation area can be ablated, thereby achieving the effect of clearing the sympathetic nerves in the ablation area, which is beneficial to the patient. Then, within a preset time period after the ablation energy is applied to the ablation area, the cardiac output parameters of the target electrode are continuously obtained, so that the effect of ablation can be judged by the cardiac output parameters later. Then, when the cardiac output parameter has not increased relative to the preset benchmark threshold, it can be preliminarily judged that the result of ablation is ineffective ablation. However, in order to ensure the accuracy of the judgment, it is necessary to combine the judgment with the ECG signal, so an electrical stimulation signal is provided to the target electrode to activate the sympathetic nerves in the ablation area, so as to apply stimulation energy to the ablation area and obtain the ECG signal of the target electrode's target, and then determine the ablation result of the ablation area based on the ECG signal. Therefore, this scheme makes a preliminary judgment on the ablation result through the cardiac output parameter, and then further judges the ablation result through the ECG signal. By combining the cardiac output parameter and the ECG signal, the accuracy of the ablation result judgment is improved, and the ablation result can be accurately determined, which is convenient for doctors to accurately grasp the specific circumstances of ablation and improve the surgical effect.

[0081] In one embodiment, Figure 2 As shown, the ablation control method further includes: step S200, when the cardiac output parameter increases relative to a preset reference threshold, determining that the ablation result of the ablation area is effective ablation.

[0082] Specifically, the ablation result of the ablation area can be determined to be effective based on the cardiac output parameter, so there is no need to perform the subsequent steps of applying stimulation energy to the ablation area and obtaining the ECG signal of the target electrode, and then judging based on the ECG signal. Judging based on the cardiac output parameter is simpler and more convenient, and has less stimulation to the patient.

[0083] Specifically, blocking the sympathetic nerves around the pulmonary artery can reduce pulmonary artery pressure, improve the right heart state, and increase cardiac output, so cardiac output will increase. By continuously acquiring the cardiac output parameters of the target electrode's target, continuous cardiac output (CCO) detection can be performed, and the CCO before and after sympathetic nerve ablation can be compared. An increase in CCO indicates that the ablation is effective.

[0084] In this embodiment, when the cardiac output parameter increases relative to a preset reference threshold, the ablation result of the ablation area is determined to be effective ablation, so that it can be simply, intuitively and conveniently determined whether the ablation result is effective ablation.

[0085] In one embodiment, Figure 3 As shown, step S110, within a preset time period after ablation energy is applied to the ablation area, continuously obtaining the cardiac output parameters of the target electrode's target object, includes: steps S300-S310.

[0086] Step S300, within a preset time period after ablation energy is applied to the ablation area, a preset area to be heated of the subject is heated, and temperature parameters of a preset temperature monitoring area are obtained.

[0087] Specifically, a catheter is used to intervene in the body of the subject, and a thermosensitive guide wire is arranged at the front end of the catheter. The position of the catheter is adjusted so that the thermosensitive guide wire is located in a preset heating area of ​​the subject (for example, the right atrium and right ventricle of the heart), and then a pulse energy signal is sent to the thermosensitive guide wire every 60 seconds to heat the blood around the thermosensitive guide wire, and then the temperature parameters (blood temperature) of the preset temperature monitoring area (for example, the front and back of the main body of the pulmonary artery) are obtained.

[0088] Step S310, determining the cardiac output parameter of the subject within the preset time period according to the temperature parameter within the preset time period.

[0089] Specifically, after obtaining the temperature parameters within the preset time period, a thermal dilution curve can be obtained according to the change of blood temperature within the preset time period. The thermal dilution curve includes the changing relationship between the temperature of the blood and time. The area of ​​the part enclosed by the thermal dilution curve and time can be recorded as the cardiac output parameter (continuous cardiac output) of the object.

[0090] In this embodiment, a method for obtaining cardiac output parameters of a target electrode's target object is provided, so as to facilitate subsequent analysis of ablation results according to the cardiac output parameters.

[0091] In one embodiment, Figure 4 As shown, step S130, determining the ablation result of the ablation area according to the electrocardiogram signal, includes steps S400-S420.

[0092] Step S400, determining the ablation category corresponding to the ablation area according to the change trend of the ECG signal and the preset ECG range.

[0093] Among them, the ablation category includes a recommended ablation category and a no-ablation-needed category.

[0094] Specifically, in the process of applying stimulation energy to the ablation area, the ECG signal of the target object is obtained in real time. When the stimulation energy acts on the sympathetic nerves, the ECG signal of the target object will change significantly, while when the stimulation energy does not act on the sympathetic nerves, the change in the ECG signal of the target object is not obvious. That is to say, in the process of applying stimulation energy to the ablation area, there will be certain differences in the ECG signal of the target object when the stimulation energy is applied to the pulmonary artery sympathetic nerves in the ablation area and when the stimulation energy is not applied to the pulmonary artery sympathetic nerves in the ablation area. Therefore, according to the change trend of the ECG signal, combined with the preset ECG range as a reference standard, it can be determined whether the pulmonary artery sympathetic nerves in the ablation area have been ablated, and then according to whether the pulmonary artery sympathetic nerves have been ablated, the ablation category corresponding to the ablation area can be determined.

[0095] Step S410: When it is determined that the ablation category corresponding to the ablation area is a category that does not require ablation, the ablation result of the ablation area is determined to be effective ablation.

[0096] Specifically, when it is determined that the sympathetic nerves in the ablation area have been ablated, the ablation category corresponding to the ablation area is a category that does not require ablation, so the previous ablation of the ablation area is effective.

[0097] Step S420: When it is determined that the ablation category corresponding to the ablation area is the recommended ablation category, the ablation result of the ablation area is determined to be invalid ablation.

[0098] Specifically, when it is determined that the sympathetic nerves in the ablation area have not been ablated and sympathetic nerves still exist, the ablation category corresponding to the ablation area is the recommended ablation category, so the previous ablation of the ablation area is invalid.

[0099] In this embodiment, after the cardiac output parameter is used to determine the ablation result, stimulation energy is applied to the ablation area and the ECG signal of the target electrode is obtained for further determination, thereby achieving a more accurate determination of the ablation result.

[0100] In one embodiment, Figure 5 As shown, step S400, according to the change trend of the ECG signal and the preset ECG range, determines the ablation category corresponding to the ablation area. It includes: steps S500-S530.

[0101] Step S500: convert the type of the ECG signal into a frequency domain signal to obtain a frequency domain ECG signal.

[0102] Specifically, the ECG signal of the subject is measured by a heart rate measurement device, and then the obtained time domain ECG signal is transformed by Fourier or Laplace transform to obtain the frequency domain ECG signal. Compared with the time domain signal, the frequency domain signal can better reflect the relationship between the frequency and amplitude of the ECG signal, so that the frequency change of the ECG signal can be analyzed more intuitively.

[0103] For example, the waveform of the frequency domain ECG signal can be as follows: Figure 6 As shown, Figure 6 It is the autopower spectrum commonly used in frequency domain electrocardiogram. It is composed of a series of spectral peaks, which are arranged in order of frequency. When the heart rhythm is regular, the spectral peaks are discrete, regular in shape, and roughly equal in spacing. Starting from the low frequency, the first spectral peak is the fundamental frequency①, and its frequency position is related to the heart rate, that is, when the fundamental frequency is 1Hz, the heart rate of the subject is 60 / min. The first spectral peak is also called the fundamental wave, which is usually the one with the highest amplitude among all the spectral peaks. The subsequent peaks are called harmonics. Figure 6 The frequency domain ECG signal shown in the figure is filtered to obtain Figure 7 The electrocardiogram, Figure 7 Only the fundamental frequency is retained.

[0104] Step S510, determining the change rate of the frequency domain ECG signal according to the frequency domain ECG signal and a preset reference frequency domain ECG signal.

[0105] Specifically, before applying stimulation energy to the ablation area, the ECG signal of the subject is first obtained to obtain a preset reference frequency domain ECG signal as a reference value, and the change rate of the frequency domain ECG signal relative to the reference frequency domain ECG signal is used as the change rate of the frequency domain ECG signal.

[0106] For example, the average ECG signal of the subject within 10 seconds before applying stimulation energy to the ablation region may be recorded, and then a preset reference frequency domain ECG signal may be obtained based on the average ECG signal.

[0107] Step S520: When the rate of change of the frequency domain ECG signal is within a preset ECG range, the ablation region is determined to be a category where ablation is not required.

[0108] Specifically, when the rate of change of the frequency domain ECG signal is within a preset ECG range, it means that the heart rate is appropriate, which means that there is no sympathetic nerve in the ablation area, so the ablation area is determined to be a category that does not require ablation.

[0109] For example, the preset ECG range may be plus or minus 10% of the reference frequency domain ECG signal. Figure 8 As shown, Figure 8The dotted line in the figure is the waveform of the reference frequency domain ECG signal, and the solid lines are the waveforms of the -10% change rate and +10% change rate of the reference frequency domain ECG signal. As long as the fundamental frequency value of the frequency domain ECG signal fluctuates within the range of the two solid lines, that is, within the preset ECG range, the ablation area is determined to be a category that does not require ablation.

[0110] Step S530 , when the rate of change of the frequency domain ECG signal is outside the preset ECG range, determining the ablation region as a recommended ablation category.

[0111] Specifically, when the rate of change of the frequency domain ECG signal is outside the preset ECG range, it means that the heart rate is inappropriate (may be too fast or too slow), which means that sympathetic nerves exist in the ablation area, so the ablation area is determined to be a recommended ablation category.

[0112] For example, the preset ECG range may be plus or minus 10% of the reference frequency domain ECG signal. Fig. 9 As shown, Fig. 9 The dotted line in the figure is the waveform of the reference frequency domain ECG signal, and the solid line is the waveform of the +10% change rate of the reference frequency domain ECG signal. Fig.10 As shown, when the fundamental frequency value of the frequency domain ECG signal is greater than Fig. 9 When the solid line in the middle is shown, it means that the rate of change of the frequency domain ECG signal is too large, which is recorded as a tachycardia, and the ablation area is determined to be the recommended ablation category.

[0113] like Fig.11 As shown, Fig.11 The dotted line in the figure is the waveform of the reference frequency domain ECG signal, and the solid line is the waveform of the reference frequency domain ECG signal with a -10% change rate. Fig.12 As shown, when the fundamental frequency value of the frequency domain ECG signal is less than Fig.11 When the solid line in the middle is smaller than the solid line, it means that the rate of change of the frequency domain ECG signal is too small, which is recorded as a slow heartbeat, and the ablation area is determined to be the recommended ablation category.

[0114] Exemplarily, a table for classifying frequency domain ECG signals is shown in Table 1:

[0115] Table 1. Classification of frequency domain ECG signals

[0116]

[0117] Specifically, the present application determines the autonomic nervous response (bradycardia, systemic blood pressure changes, coughing and diaphragmatic spasm) by high-frequency stimulation of the ablation area, and selects the target point that causes bradycardia or tachycardia as the ablation site, which can avoid the site that causes coughing and diaphragmatic spasm, avoid phrenic nerve paralysis, reduce invalid ablation points, reduce the risk of blind ablation uncertainty, improve treatment effect, reduce vascular damage, and improve surgical safety. Automatic classification to determine whether ablation is recommended can reduce the difficulty of surgery and reduce the learning time of doctors.

[0118] In this embodiment, the ablation category of the ablation area is determined based on the change trend of the ECG signal and the preset ECG range, so as to accurately determine the ablation result of the ablation area.

[0119] In one embodiment, Fig.13 As shown, the ablation control method also includes: steps S1300-S1310.

[0120] Step S1300, when the amplitude of the frequency domain ECG signal is greater than a first threshold, a warning signal is issued.

[0121] Step S1310, when the amplitude of the frequency-domain electrocardiographic signal is greater than a second threshold, stop providing the electrical stimulation signal to the target electrode.

[0122] The second threshold is greater than the first threshold.

[0123] Specifically, the strength of the ECG signal of the subject can be determined based on the amplitude of the frequency domain ECG signal. When the amplitude exceeds the allowable range (the range can be set on the radio frequency instrument, parameter range: ±10% to ±20%), the subject may be in danger. At this time, in order to protect the subject, it is necessary to issue an alarm or stop applying stimulation energy. The warning value can be set as the first threshold and the cut-off value can be set as the second threshold. When the fundamental wave amplitude is greater than the first threshold, a warning signal is issued to alert the doctor. When the fundamental wave amplitude is greater than the second threshold, a warning signal is issued to alert the doctor and the device is directly powered off to stop applying stimulation energy.

[0124] In this embodiment, based on the amplitude of the frequency-domain electrocardiographic signal, the condition of the subject can be monitored to ensure the safety of the subject.

[0125] In one embodiment, Fig.14 As shown, the ablation control method further includes: step S1400, when it is determined that the ablation result of the ablation area is invalid ablation, jump to step S100, provide an ablation signal to the target electrode to apply ablation energy to the ablation area.

[0126] In this embodiment, when it is determined that the ablation result of the ablation area is invalid, the ablation area is ablated again to ensure the ablation effect.

[0127] In one embodiment, Fig.15 As shown, in step S100, when the ablation area is determined, before providing the ablation signal to the target electrode, the ablation control method further includes: steps S1500-S1520.

[0128] Step S1500: providing an electrical stimulation signal to at least one electrode.

[0129] Specifically, the patient is first anesthetized, punctured, and the catheter is in place. Then the patient's pulmonary artery is three-dimensionally modeled, and a geometric model of the pulmonary artery is created using a pulmonary artery catheter. The catheter is attached to a pre-calibrated stimulation point, and then the radiofrequency instrument selects to provide an electrical stimulation signal to at least one electrode on the catheter.

[0130] Step S1510, in the process of providing the electrical stimulation signal to at least one electrode, obtaining the electrocardiogram signal of the subject of at least one electrode.

[0131] Step S1520, determining whether the stimulation area corresponding to the current electrode is an ablation area according to the electrocardiogram signal.

[0132] Specifically, a plurality of electrodes are arranged on the catheter in the body of the interventional subject, and an electrical stimulation signal is provided to at least one electrode in turn, and then the physiological parameters of the target subject are obtained. Based on the changes in the electrocardiogram signal under the action of the electrical stimulation signal, it can be determined whether the electrical stimulation signal is applied to the pulmonary artery sympathetic nerve, and then it can be determined whether the stimulation area corresponding to the at least one electrode is the ablation area.

[0133] In which case, when the stimulation area corresponding to the current electrode is the ablation area, the current electrode serves as the target electrode.

[0134] Exemplarily, Table 2 is a table for determining ablation results in this application.

[0135] Table 2. Ablation result judgment table

[0136]

[0137] In this embodiment, an electrical stimulation signal is provided to at least one electrode, an electrocardiogram signal of an object of action of at least one electrode is acquired, and then the ablation area is determined according to the electrocardiogram signal, thereby achieving accurate judgment of the ablation area.

[0138] It should be understood that although Figure 1-Figure 5 , Figure 13-15The steps in the flowchart are shown in sequence as indicated by the arrows, but these steps are not necessarily executed in the order indicated by the arrows. Unless otherwise specified in this document, there is no strict order restriction for the execution of these steps, and these steps can be executed in other orders. Moreover, Figure 1-Figure 5 , Figure 13-15 At least part of the steps may include multiple steps or multiple stages. These steps or stages are not necessarily performed at the same time, but can be performed at different times. The execution order of these steps or stages is not necessarily sequential, but can be performed in turn or alternately with other steps or at least part of the steps or stages in other steps.

[0139] In one embodiment, Fig.16 As shown, an ablation system is provided, including: an electrode assembly, an ablation module 30, a stimulation module 40, a collection module 50, and a control module 60. Among them:

[0140] The electrode assembly includes a catheter 10 and a plurality of electrodes 20 spaced apart on the catheter 10 .

[0141] Wherein, the catheter 10 includes a support portion and an electrode portion, and the electrode portion is a flexible hose. A plurality of electrodes 20 are arranged at intervals on the electrode portion. The support portion can be a sheath of the electrode portion, which is used to support the catheter 10 to prevent the catheter 10 from being deformed, and to enable the catheter 10 to smoothly enter the body of the target object, while the electrode portion is a flexible hose that can be bent at will, on the one hand to avoid stabbing the tissue of the target object, and on the other hand to facilitate bending to better cover the area of ​​the target object's tissue that needs to be ablated. The electrode 20 is a device that can output energy and can release energy near its setting position to achieve the effect of stimulation or ablation. Each electrode 20 is arranged at intervals on the catheter 10, so when the catheter 10 is inserted into the body of the target object, the energy released by each electrode 20 can cover different areas.

[0142] The ablation module 30 is respectively connected to the plurality of electrodes 20 for providing an ablation signal to each electrode 20 .

[0143] After receiving the ablation signal, the electrode 20 outputs ablation energy for clearing the sympathetic nerves.

[0144] Specifically, the ablation module 30 can output an ablation signal, which can be a high-power ablation energy in watts. The high-power ablation energy refers to energy that can cause destructive damage to cells in a specific part and cause them to die when acting on the specific part. Exemplarily, the output power of the ablation energy can be 0-40W, which can be adjusted as needed.

[0145] The stimulation modules 40 are respectively connected to the plurality of electrodes 20 , and are used to provide electrical stimulation signals to each electrode 20 .

[0146] After receiving the ablation signal, the electrode 20 outputs stimulation energy for activating the sympathetic nerves.

[0147] Specifically, the stimulation module 40 can provide an electrical stimulation signal to each electrode 20. The energy of the electrical stimulation signal is relatively small, usually at the milliampere level. It can be used to electrically stimulate a specific part in the form of a pulse wave. When the stimulation energy acts on a specific part, it will not cause damage to the cells in the specific part, but will cause changes in the physiological parameters of the target object. Specifically, when the electrical stimulation signal acts on the pulmonary artery sympathetic nerve, the physiological parameters of the target object will change significantly, and when the electrical stimulation signal does not act on the pulmonary artery sympathetic nerve, the changes in the physiological parameters of the target object are not obvious.

[0148] Exemplarily, the stimulation module 40 may output a current of 0-30 mA or a voltage of 0-15 V. The output current or voltage may be in the form of pulse energy with a frequency of 0.5-40 Hz and a pulse width of 0.5, 1, or 2 milliseconds.

[0149] The acquisition module 50 is used to acquire cardiac output parameters and electrocardiogram signals of the subject to which the multiple electrodes 20 act.

[0150] The control module 60 is respectively connected to the ablation module 30, the stimulation module 40 and the acquisition module 50, and is used to control the ablation module 30 to provide an ablation signal to the target electrode to apply ablation energy to the ablation area when the ablation area is determined. The cardiac output parameters of the target electrode's target object are continuously acquired within a preset time period after the ablation energy is applied to the ablation area. When the cardiac output parameters do not increase relative to the preset reference threshold, the stimulation module 40 is controlled to provide an electrical stimulation signal to the target electrode to apply stimulation energy to the ablation area and acquire the electrocardiogram signal of the target electrode's target object. According to the electrocardiogram signal, the ablation result of the ablation area is determined, wherein the ablation result includes one of effective ablation and ineffective ablation.

[0151] In this embodiment, when the controller determines the ablation area, it controls the ablation module 30 to provide an ablation signal to the target electrode, so that the target electrode releases ablation energy to the ablation area, and the sympathetic nerves to be ablated in the ablation area can be ablated, thereby achieving the effect of clearing the sympathetic nerves in the ablation area, which is beneficial to the patient. Then, within a preset time period after the ablation energy is applied to the ablation area, the cardiac output parameters of the target electrode 20 are continuously obtained, so as to judge the effect of ablation by the cardiac output parameters later. Then, when the cardiac output parameter has not increased relative to the preset benchmark threshold, it can be preliminarily judged that the result of the ablation is ineffective ablation. However, in order to ensure the accuracy of the judgment, it is necessary to combine the judgment with the ECG signal. Therefore, the stimulation module provides an electrical stimulation signal to the target electrode to activate the sympathetic nerves in the ablation area, so as to apply stimulation energy to the ablation area and obtain the ECG signal of the target electrode, and then determine the ablation result of the ablation area based on the ECG signal. Therefore, this scheme makes a preliminary judgment on the ablation result through the cardiac output parameter, and then further judges the ablation result through the ECG signal. By combining the cardiac output parameter and the ECG signal, the accuracy of the ablation result judgment is improved, and the ablation result can be accurately determined, which is convenient for doctors to accurately grasp the specific circumstances of the ablation and improve the surgical effect.

[0152] In one embodiment, Fig.17 As shown, the acquisition module 50 includes: a thermosensitive guide wire 51, a temperature sensor component 52, and a heart rate acquisition unit 53. Among them:

[0153] The heat-sensitive guide wire 51 is disposed on the catheter 10 .

[0154] Specifically, a thermosensitive guide wire 51 is provided at the front end of the catheter 10. By adjusting the position of the catheter 10, the thermosensitive guide wire 51 is located in a preset heating area of ​​the object (for example, the right atrium and right ventricle of the heart), and then a pulse energy signal is sent to the thermosensitive guide wire 51 every 60 seconds to heat the blood around the thermosensitive guide wire 51.

[0155] The temperature sensing assembly 52 is disposed on the catheter 10 .

[0156] Specifically, the temperature sensing component 52 is located in a preset temperature monitoring area (e.g., the front and back of the pulmonary artery body), and can directly collect temperature parameters (blood temperature).

[0157] The heart rate acquisition unit 53 is connected to an external heart rate measuring device to obtain the electrocardiogram signal measured by the heart rate measuring device.

[0158] The heart rate acquisition unit 53 may be a communication module, and the heart rate measurement device may measure the heart rate value of the target object and then transmit the value to the heart rate acquisition unit 53 through communication.

[0159] The control module 60 is respectively connected to the thermistor guide wire 51, the temperature sensor component 52, and the heart rate acquisition unit 53, and is used to provide a pulse signal to the thermistor guide wire 51 so that the thermistor guide wire 51 heats the preset area to be heated, and obtains the temperature parameters of the preset temperature monitoring area through the temperature sensor component 52, determines the cardiac output parameters of the object within the preset time period according to the temperature parameters within the preset time period, and obtains the electrocardiogram signal through the heart rate acquisition unit 53.

[0160] For example, Fig.18 As shown, the catheter 10 is provided with a thermosensitive guide wire 51, an electrode 20, a temperature sensor assembly 52, and an infusion hole 54. An infusion pump can be used to infuse physiological saline or the like into the infusion hole 54, thereby infusing it into the catheter 10, which can play a role in cooling down during the ablation process.

[0161] Specifically, after obtaining the temperature parameters within the preset time period, a thermal dilution curve can be obtained according to the change of blood temperature within the preset time period. The thermal dilution curve includes the changing relationship between the temperature of the blood and time. The area of ​​the part enclosed by the thermal dilution curve and time can be recorded as the cardiac output parameter (continuous cardiac output) of the object.

[0162] In this embodiment, the area to be heated is heated by using a thermosensitive guide wire 51, and the temperature is collected by the temperature sensor assembly 52, so that the controller can determine the cardiac output parameter of the subject within a preset time period.

[0163] In one embodiment, Fig.19 As shown, the ablation system further includes: a neutral electrode 70. The neutral electrode 70 is connected to the stimulation module 40 and the ablation module 30 respectively. The neutral electrode 70 is one of the electrodes 20 or an electrode 20 independently arranged in other areas of the catheter 10.

[0164] The neutral electrode 70 may be attached to the skin surface of the target object.

[0165] The control module 60 is used to control the stimulation module 40 to open a path between at least one electrode 20 and the neutral electrode 70 to establish a stimulation circuit.

[0166] The neutral electrode 70 and at least one electrode 20 form a stimulation circuit, and the electrical stimulation signal is released from at least one electrode 20 and conducted to the neutral electrode 70 to form a circuit, so as to stimulate the area between the at least one electrode 20 and the neutral electrode 70 .

[0167] The stimulation module 40 provides an electrical stimulation signal to at least one electrode 20 through a stimulation circuit.

[0168] In this embodiment, by providing a neutral electrode 70, it is convenient to construct a stimulation circuit with at least one electrode 20 to achieve the release of an electrical stimulation signal, thereby facilitating electrical stimulation of the target tissue.

[0169] In one embodiment, Fig. 20 As shown, an ablation control device is provided, comprising: an ablation module 2001, a cardiac output acquisition module 2002, a stimulation module 2003, and a result determination module 2004, wherein:

[0170] The ablation module 2001 is used to provide an ablation signal to the target electrode when the ablation area is determined, so as to apply ablation energy to the ablation area, wherein the ablation energy is used to clear the sympathetic nerves in the ablation area.

[0171] The cardiac output acquisition module 2002 is used to continuously acquire the cardiac output parameters of the target electrode's target object within a preset time period after ablation energy is applied to the ablation area.

[0172] The stimulation module 2003 is used to provide an electrical stimulation signal to the target electrode when the cardiac output parameter does not increase relative to a preset reference threshold value, so as to apply stimulation energy to the ablation area and obtain the ECG signal of the target electrode's target, wherein the stimulation energy is used to activate the sympathetic nerves in the ablation area.

[0173] The result determination module 2004 is used to determine the ablation result of the ablation area according to the electrocardiogram signal, wherein the ablation result includes one of effective ablation and ineffective ablation.

[0174] In one embodiment, the cardiac output acquisition module includes: a temperature acquisition unit and a parameter determination unit.

[0175] The temperature acquisition unit is used to heat the preset area to be heated within a preset time period after ablation energy is applied to the ablation area, and to acquire the temperature parameters of the preset temperature monitoring area.

[0176] The parameter determination unit is used to determine the cardiac output parameter of the subject within the preset time period according to the temperature parameter within the preset time period.

[0177] In one embodiment, the result determination module includes: a category number determination unit, a valid unit, and an invalid unit, wherein:

[0178] The category number determination unit is used to determine the ablation category corresponding to the ablation area according to the change trend of the ECG signal and the preset ECG range, wherein the ablation category includes a recommended ablation category and a no-ablation category.

[0179] The valid unit is used to determine that the ablation result of the ablation area is a valid ablation when it is determined that the ablation category corresponding to the ablation area is a category that does not require ablation.

[0180] The invalidation unit is used to determine that the ablation result of the ablation area is invalid ablation when it is determined that the ablation category corresponding to the ablation area is the recommended ablation category.

[0181] In one embodiment, the ablation control device further includes: a stimulation providing module, an electrocardiogram acquisition module, and a driving module, wherein:

[0182] The stimulation providing module is used to provide an electrical stimulation signal to at least one electrode.

[0183] The ECG acquisition module is used to acquire the ECG signal of the object of at least one electrode during the process of providing the electrical stimulation signal to at least one electrode.

[0184] The driving module is used to determine whether the stimulation area corresponding to the current electrode is the ablation area according to the electrocardiogram signal, wherein when the stimulation area corresponding to the current electrode is the ablation area, the current electrode is used as the target electrode.

[0185] For the specific definition of the ablation control device, please refer to the definition of the ablation control method above, which will not be repeated here. The various modules in the above-mentioned ablation control device can be implemented in whole or in part by software, hardware and a combination thereof. The above-mentioned modules can be embedded in or independent of the processor in the computer device in the form of hardware, or can be stored in the memory of the computer device in the form of software, so that the processor can call and execute the operations corresponding to the above modules. It should be noted that the division of modules in the embodiment of the present application is schematic and is only a logical function division. There may be other division methods in actual implementation.

[0186] In one embodiment, a computer device is provided, wherein the internal structure diagram of the computer device can be as follows: Fig.21 As shown. The computer device includes a processor, a memory and a network interface connected through a system bus. Among them, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program and a database. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The network interface of the computer device is used to communicate with an external terminal through a network connection. When the computer program is executed by the processor, an ablation control method is implemented.

[0187] Those skilled in the art will understand that Fig.21The structure shown in the figure is only a block diagram of a part of the structure related to the solution of the present application, and does not constitute a limitation on the computer device to which the solution of the present application is applied. The specific computer device may include more or fewer components than those shown in the figure, or combine certain components, or have a different arrangement of components.

[0188] In one embodiment, a computer device is provided, including a memory and a processor, wherein a computer program is stored in the memory, and the processor implements the steps in the above-mentioned method embodiments when executing the computer program.

[0189] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored. When the computer program is executed by a processor, the steps in the above-mentioned method embodiments are implemented.

[0190] In one embodiment, a computer program product is provided, including a computer program, which implements the steps in the above method embodiments when executed by a processor.

[0191] Those of ordinary skill in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to memory, storage, database or other media used in the embodiments provided in this application can include at least one of non-volatile and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory or optical memory, etc. Volatile memory can include random access memory (RAM) or external cache memory. As an illustration and not limitation, RAM can be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM).

[0192] In the description of this specification, the description with reference to the terms "some embodiments", "other embodiments", "ideal embodiments", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic descriptions of the above terms do not necessarily refer to the same embodiment or example.

[0193] The technical features of the above embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0194] The above-mentioned embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the attached claims.

Claims

1. An ablation control method, characterized in that: include: When the ablation area is determined, providing an ablation signal to the target electrode to apply ablation energy to the ablation area, wherein the ablation energy is used to remove sympathetic nerves in the ablation area; within a preset time period after ablation energy is applied to the ablation region, continuously acquiring a cardiac output parameter of a subject to which the target electrode is applied; When the cardiac output parameter does not increase relative to a preset reference threshold, providing an electrical stimulation signal to the target electrode to apply stimulation energy to the ablation region and obtain an electrocardiogram signal of a subject of the target electrode, wherein the stimulation energy is used to activate sympathetic nerves in the ablation region; The ablation result of the ablation area is determined according to the electrocardiogram signal, wherein the ablation result includes one of effective ablation and ineffective ablation.

2. The ablation control method according to claim 1, characterized in that: The method further comprises: When the cardiac output parameter increases relative to the preset reference threshold, the ablation result of the ablation area is determined to be effective ablation.

3. The ablation control method according to claim 1, characterized in that: The step of continuously acquiring the cardiac output parameter of the target electrode within a preset time period after applying ablation energy to the ablation area includes: Within a preset time period after applying ablation energy to the ablation area, heating the preset area to be heated of the subject, and acquiring temperature parameters of a preset temperature monitoring area; A cardiac output parameter of the subject within the preset time period is determined according to the temperature parameter within the preset time period.

4. The ablation control method according to claim 1, characterized in that: Determining the ablation result of the ablation area according to the electrocardiogram signal includes: Determining the ablation category corresponding to the ablation area according to the change trend of the electrocardiogram signal and the preset electrocardiogram range, wherein the ablation category includes a recommended ablation category and a no-ablation category; In the case where it is determined that the ablation category corresponding to the ablation area is a category that does not require ablation, determining that the ablation result of the ablation area is effective ablation; When it is determined that the ablation category corresponding to the ablation area is the recommended ablation category, the ablation result of the ablation area is determined to be invalid ablation.

5. The ablation control method according to claim 4, characterized in that: Determining the ablation category corresponding to the ablation area according to the change trend of the electrocardiogram signal and a preset electrocardiogram threshold includes: Convert the type of the electrocardiogram signal into a frequency domain signal to obtain a frequency domain electrocardiogram signal; Determining a rate of change of the frequency-domain ECG signal according to the frequency-domain ECG signal and a preset reference frequency-domain ECG signal; When the rate of change of the frequency domain ECG signal is within the preset ECG range, determining that the ablation area is a category where ablation is not required; When the rate of change of the frequency-domain ECG signal is outside the preset ECG range, the ablation region is determined to be a recommended ablation category.

6. The ablation control method according to claim 5, characterized in that: The method further comprises: When the amplitude of the frequency-domain electrocardiogram signal is greater than a first threshold, issuing a warning signal; When the amplitude of the frequency-domain electrocardiographic signal is greater than a second threshold, stopping providing the electrical stimulation signal to the target electrode, wherein the second threshold is greater than the first threshold.

7. The ablation control method according to any one of claims 1 to 6, characterized in that: The method further comprises: In the case where it is determined that the ablation result of the ablation area is ineffective ablation, the process jumps to the step of providing an ablation signal to the target electrode to apply ablation energy to the ablation area.

8. The ablation control method according to any one of claims 1 to 6, characterized in that: In the case where the ablation area is determined, before the step of providing the ablation signal to the target electrode, the method further includes: providing an electrical stimulation signal to at least one electrode; In the process of providing the electrical stimulation signal to at least one of the electrodes, obtaining an electrocardiogram signal of a subject to which at least one of the electrodes is applied; Determine whether the stimulation area corresponding to the current electrode is the ablation area according to the electrocardiogram signal, wherein, when the stimulation area corresponding to the current electrode is the ablation area, the current electrode serves as the target electrode.

9. An ablation system, characterized in that: include: An electrode assembly, comprising a catheter and a plurality of electrodes spaced apart on the catheter; an ablation module, connected to the plurality of electrodes respectively, and used for providing an ablation signal to each of the electrodes, wherein after receiving the ablation signal, the electrode outputs an ablation energy for clearing the sympathetic nerves; a stimulation module, connected to the plurality of electrodes respectively, and used for providing an electrical stimulation signal to each of the electrodes, wherein after receiving the ablation signal, the electrode outputs stimulation energy for activating the sympathetic nerve; A collection module, used for collecting cardiac output parameters and electrocardiogram signals of the subject to which the multiple electrodes act; The control module is connected to the ablation module, the stimulation module and the acquisition module respectively, and is used to control the ablation module to provide an ablation signal to the target electrode so as to apply ablation energy to the ablation area when the ablation area is determined; continuously obtain the cardiac output parameter of the target electrode within a preset time period after the ablation energy is applied to the ablation area; when the cardiac output parameter does not increase relative to a preset reference threshold, control the stimulation module to provide an electrical stimulation signal to the target electrode so as to apply stimulation energy to the ablation area and obtain the electrocardiogram signal of the target electrode; determine the ablation result of the ablation area according to the electrocardiogram signal, wherein the ablation result includes one of effective ablation and ineffective ablation.

10. The ablation system according to claim 9, characterized in that: The acquisition module comprises: A heat-sensitive guide wire, arranged on the catheter; A temperature sensing component is arranged on the conduit; A heart rate acquisition unit, connected to an external heart rate measurement device, for acquiring the electrocardiogram signal measured by the heart rate measurement device; The control module is respectively connected to the thermistor guide wire, the temperature sensing component, and the heart rate acquisition unit, and is used to provide a pulse signal to the thermistor guide wire so that the thermistor guide wire heats a preset area to be heated, and obtains the temperature parameters of the preset temperature monitoring area through the temperature sensing component, determines the cardiac output parameters of the object within the preset time period according to the temperature parameters within the preset time period, and obtains the electrocardiogram signal through the heart rate acquisition unit.

11. An ablation control device, characterized in that: include: an ablation module, configured to provide an ablation signal to a target electrode when an ablation region is determined, so as to apply ablation energy to the ablation region, wherein the ablation energy is used to clear sympathetic nerves in the ablation region; A cardiac output acquisition module, used for continuously acquiring cardiac output parameters of the target electrode's target object within a preset time period after ablation energy is applied to the ablation area; a stimulation module, configured to provide an electrical stimulation signal to the target electrode when the cardiac output parameter does not increase relative to a preset reference threshold value, so as to apply stimulation energy to the ablation area and obtain an electrocardiogram signal of an object of the target electrode, wherein the stimulation energy is used to activate sympathetic nerves in the ablation area; The result determination module is used to determine the ablation result of the ablation area according to the electrocardiogram signal, wherein the ablation result includes one of effective ablation and ineffective ablation.

12. A computer device comprising a memory and a processor, wherein the memory stores a computer program, characterized in that: When the processor executes the computer program, the steps of the method according to any one of claims 1 to 8 are implemented.

13. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 8 are implemented.

14. A computer program product comprising a computer program, characterized in that When the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 8 are implemented.

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