A device for constructing an intervertebral disc degeneration model by using a mouse simulation

Abstract

The application provides a device for simulating and constructing an intervertebral disc degeneration model by using a mouse, and belongs to the technical field of medical research. The device comprises a mounting base plate, a support rod is connected to the middle of the top of the mounting base plate, a top seat is fixedly connected to the top of the support rod, and a ring seat is fixedly connected to the inner side of the top seat. The body clamping mechanism can accurately clamp the body of the animal, and the body bending or unfolding is realized by cooperating with the electric push rod. The experimental adaptability is improved in cooperation with the limb positioning mechanism, the pathological process of human intervertebral disc degeneration is simulated, the limbs of the animal are fixed by the anti-skid plate of the limb positioning mechanism, different volume animals can be adapted, the rotation shaft design avoids the fracture of the limbs of the animal, the angle adjusting assembly and the arc displacement assembly make the limbs of the animal swing flexibly and move up and down, the convenience and the adjusting and adapting performance of the device are improved, and more accurate data and reliable experimental conditions are provided for the lumbar spine pathological research as a whole.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical research, more particularly, to a device for simulating and constructing an intervertebral disc degeneration model by using mice. BACKGROUND

[0002] Human intervertebral disc degeneration is a very common pathological process of spinal disease, the intervertebral disc is located between two adjacent vertebral bodies, mainly composed of nucleus pulposus, annulus fibrosus and cartilage endplate, under the influence of various factors, the intervertebral disc will gradually degenerate, among which, the continuous growth of age is an important factor, with the passage of time, the functions of the human body gradually decline, and the intervertebral disc is no exception, long-term poor posture, such as sitting for a long time, hunchback, etc., will make the intervertebral disc continuously bear abnormal pressure, accelerate the degeneration process, excessive physical labor will bring a huge burden to the intervertebral disc, repeated stress and injury can easily lead to the annulus fibrosus to crack, and then greatly reduce the stability of the intervertebral disc, in addition, trauma can also directly cause damage to the intervertebral disc and then lead to degeneration.

[0003] At present, in the process of exploring the pathological process of human intervertebral disc degeneration, a model is usually needed to simulate, in the existing simulation practice, some vertebral mammals similar to the human body are often selected for simulation test, such as rabbits, mice and other vertebral mammals, however, the existing auxiliary degeneration model device has many limitations in actual application, on the one hand, the device can only position the limbs of the animal, after positioning, the limbs and body of the experimental simulation animal cannot be flexibly adjusted, obviously, such a device cannot realize the adjustment of the complex movements of the experimental animal body, such as forward bending, backward stretching, left and right lateral bending and left and right rotation, on the other hand, due to the inability to adjust these complex movements, it is difficult to reproduce the etiology, incidence and pathological changes of intervertebral disc degeneration, at the same time, it is also difficult to accurately select the intervention segment according to the experimental requirements, there are obvious deficiencies in the controllability and standardization of the model, in summary, the existing technology indeed has certain defects and deficiencies, and it is urgent to improve and perfect it to better meet the needs of the research on the pathological process of human intervertebral disc degeneration. SUMMARY

[0004] In view of the problem in the prior art that the intervertebral disc degeneration model cannot be flexibly adjusted after being fixed, the present application aims to provide a device for simulating and constructing an intervertebral disc degeneration model by using mice.

[0005] To solve the above problems, the present application adopts the following technical scheme:

[0006] The utility model provides a device for constructing intervertebral disc degeneration model by mouse simulation, including; the top middle of installation base plate is connected with support rod, the top of support rod is fixedly connected with top seat, the inboard of top seat is fixedly connected with ring seat, the inside of ring seat is fixedly connected with body clamping mechanism, the outside of ring seat is fixedly connected with fixed frame in ring shape with equal interval, the top of fixed frame is fixedly connected with four limbs positioning mechanism;

[0007] The four limbs positioning mechanism includes a fixed plate, which is installed on the top outer end of the fixed frame by screws, the top of the fixed plate is fixedly connected with an arc displacement assembly, the top of the arc displacement assembly is fixedly connected with an angle adjusting assembly, the top of the angle adjusting assembly is fixedly connected with a linear displacement assembly, and the inner end of the linear displacement assembly is fixedly connected with a positioning assembly.

[0008] Optionally, the top of the installation base plate is provided with installation holes on both sides, the installation holes are all set as countersunk holes, and the outer corners of the base plate, the top seat and the ring seat are all set as arc shapes.

[0009] Further, the arc displacement assembly includes a support leg fixedly connected to the top of the fixed plate, the top of the support leg is fixedly connected with an arc-shaped frame, the inside of the arc-shaped frame is slidingly connected with an arc-shaped sliding block, one side of the arc-shaped sliding block is fixedly connected with a drive group, the drive group is connected with the arc-shaped frame, and one side of the drive group is connected with the bottom of the angle adjusting assembly.

[0010] Optionally, the drive group includes a base plate and an arc-shaped rack, the base plate is fixedly connected to the top of the arc-shaped sliding block, one side of the base plate close to the ring seat is fixedly connected with a mounting arm, the bottom of the mounting arm is fixedly connected with a first motor, the output end of the first motor is fixedly connected with a gear through the mounting arm, the arc-shaped rack is fixedly connected to one side of the arc-shaped frame close to the ring seat, the gear is meshingly connected with the arc-shaped rack, and one side of the base plate is connected with the angle adjusting assembly.

[0011] Optionally, the angle adjusting assembly includes a connecting block and a first hinged seat, the connecting block is fixedly connected to the top middle of the base plate, the first hinged seat is fixedly connected to the bottom outer end of the base plate, the top of the connecting block is hingedly connected with a second hinged seat, the top of the second hinged seat is connected with the bottom of the linear displacement assembly, the base plate is hingedly connected with a first electric push rod through the first hinged seat, the outer end of the first electric push rod is hingedly connected with a third hinged seat, and the top of the third hinged seat is connected with the bottom outer end of the linear displacement assembly.

[0012] Optionally, the linear displacement assembly comprises a side rail, one end of the bottom of the side rail is fixedly connected to the top of the first hinge seat, the other end of the bottom of the side rail is fixedly connected to the top of the second hinge seat, the outer end of the side rail is fixedly connected with a second motor, the output end of the second motor is fixedly connected with a one-way screw rod penetrating through the side rail, the one-way screw rod is rotationally connected to the inside of the side rail, the outer surface of the one-way screw rod is threadedly connected with a sliding block, the outer side of the sliding block is fixedly connected with a connecting arm, and the end of the connecting arm away from the second motor is connected with the positioning assembly.

[0013] Optionally, the positioning assembly comprises a rotating shaft, the rotating shaft is rotationally connected to the inner end of the connecting arm away from the second motor, the inner side of the rotating shaft is fixedly connected with a positioning square box, the top of the positioning square box is threadedly connected with a hand-screwed screw, and the end of the hand-screwed screw is rotationally connected with a clamping plate penetrating through the positioning square box.

[0014] Optionally, the body clamping mechanism comprises a mounting base, the mounting base is fixedly connected to the inner bottom of the ring seat, the inner middle portion of the mounting base is fixedly connected with a second electric push rod, and the top of the second electric push rod is fixedly connected with a clamping assembly.

[0015] Optionally, the clamping assembly comprises a receiving plate, the receiving plate is fixedly connected to the top of the second electric push rod, the middle portion of the receiving plate is fixedly connected with a guide rail, one end of the guide rail is fixedly connected with a third motor, the output end of the third motor is fixedly connected with a bidirectional screw rod penetrating through the guide rail, the two ends of the bidirectional screw rod are threadedly rotated in opposite directions, the bidirectional screw rod is rotationally connected to the inside of the guide rail, the two ends of the bidirectional screw rod are both threadedly connected with a displacement block, the top of the displacement block is fixedly connected with a clamping arm, and the outer end of the clamping arm is provided in a semicircular shape.

[0016] Optionally, the positioning assembly further comprises a supporting rod, the supporting rod is fixedly connected to the top of both sides of the clamping plate, the top of the supporting rod penetrates through the positioning square box, the bottom of the clamping plate and the inner bottom of the positioning square box are both fixedly connected with a toothed anti-skid plate, and the toothed anti-skid plate is made of silica gel material.

[0017] Compared with the prior art, the technical scheme provided by the present application has at least the following beneficial effects:

[0018] In the above scheme, by setting the body clamping mechanism, the experimental animal body is placed on the top of the receiving plate, then the third motor is started to drive the bidirectional screw to rotate, since the screw threads at both ends are opposite in rotation direction, the displacement blocks at both ends can slide reciprocally in the guide rail, thereby driving the clamping arm to reciprocally displace, realizing accurate positioning and clamping of the animal body, during use, the second electric push rod is started, when extended, the receiving plate is pushed to move upward to stretch the animal body, when retracted, the animal body is pulled to move downward to bend, cooperating with the limb positioning mechanism, the limbs and lumbar vertebrae of the experimental animal can be flexibly adjusted and swung, greatly improving the adaptability of the device in experimental exploration, which helps to more realistically simulate the pathological process of human intervertebral disc degeneration, and provides more accurate data and more reliable experimental conditions for research.

[0019] Through the limb positioning mechanism, the limbs of the experimental animal are placed in the positioning box, then the hand screw is twisted to drive the clamping plate to move downward, the support rod plays a supporting and guiding role, the two tooth-shaped anti-skid plates made of silica gel are close to each other, firmly fixing the limbs of the animal, after positioning is completed, the second motor is started to drive the unidirectional screw to rotate, driving the sliding block to slide in the side rail, thereby driving the connecting arm and the positioning box to displace, which can flexibly adapt to animals of different sizes, at the same time, since the shaft is provided, the positioning box can be self-adapted to rotate during adjustment, avoiding fracture of the limbs of the animal, effectively protecting the experimental animal, this mechanism improves the overall adaptability of the device, ensuring stable fixation of the limbs of the animal during the experiment, and providing a guarantee for the smooth progress of the research.

[0020] Through the angle adjusting assembly and the arc-shaped displacement assembly, when the limbs of the animal are fixed, the first motor is started to drive the gear to rotate, since the gear is meshed and connected with the arc-shaped rack, the arc-shaped sliding block is driven to slide in the arc-shaped frame, thereby making the positioning box arc-shaped displace, assisting in flexibly adjusting the limbs of the animal to swing reciprocally and transversely, during swinging, the first electric push rod is started to push the side rail to rotate and displace, through the linkage rotation of the first, second and third hinged seats and the connecting block, the side rail is flexibly adjusted to rotate, thereby adjusting the angle of the side rail of the linear displacement assembly, after the angle is adjusted, the stroke of the linear displacement assembly changes, the limbs of the animal can be adjusted to move up and down, which further improves the convenience of using the device, enabling the limbs of the animal to flexibly swing and displace in any direction after positioning is completed, greatly improving the adjustment and adaptability of the device during lumbar vertebrae pathological research. BRIEF DESCRIPTION OF DRAWINGS

[0021] The accompanying drawings, which are incorporated herein and constitute part of the specification, illustrate embodiments of the application and, together with the description, further serve to explain the principles of the application and to enable a person skilled in the relevant art to implement and use the application.

[0022] Figure 1 It is a schematic diagram of the overall structure of the application;

[0023] Figure 2 is a schematic view of the structure of the present application from the bottom view;

[0024] Figure 3 is a schematic view of the structure of the present application from the top view;

[0025] Figure 4 is a schematic view of the structure of the body clamping mechanism and the limb positioning mechanism of the present application;

[0026] Figure 5 is a schematic view of the structure of the body clamping mechanism of the present application from the top view;

[0027] Figure 6 is a schematic view of the structure of the body clamping mechanism of the present application from the bottom view;

[0028] Figure 7 is a schematic view of the structure of the limb positioning mechanism of the present application from the top view;

[0029] Figure 8 is a schematic view of the structure of the limb positioning mechanism of the present application from the bottom view;

[0030] Figure 9 is a schematic view of the structure of the limb positioning mechanism of the present application from the side view;

[0031] Figure 10 is a schematic view of the structure of the present application at A. Figure 1

[0032] [Reference signs]

[0033] 1, mounting base plate; 2, support rod; 3, top seat; 4, ring seat;

[0034] 5, body clamping mechanism; 51, mounting base frame; 52, second electric push rod;

[0035] 53, clamping assembly; 531, receiving plate; 532, guide rail; 533, third motor; 534, bidirectional screw rod; 535, displacement block; 536, clamping arm;

[0036] 6, fixing frame;

[0037] 7, limb positioning mechanism; 71, fixing plate;

[0038] 72, arc-shaped displacement assembly; 721, support leg; 722, arc-shaped frame; 723, arc-shaped sliding block;

[0039] 724, drive group; 7241, base plate; 7242, arc-shaped rack; 7243, mounting arm; 7244, first motor; 7245, gear;

[0040] ​73, angle adjusting assembly; 731, connecting block; 732, first hinged seat; 733, second hinged seat; 734, first electric push rod; 735, third hinged seat;

[0041] 74, linear displacement assembly; 741, side rail; 742, second motor; 743, one-way screw rod; 744, sliding block; 745, connecting arm;

[0042] 75, positioning assembly; 751, rotating shaft; 752, positioning square; 753, hand screw; 754, clamping plate; 755, supporting rod; 756, toothed non-slip plate;

[0043] 8, mounting hole.

[0044] As shown in the drawings, in order to clearly show the structure of the embodiments of the present application, specific structures and devices are marked in the drawings, but this is only for the need of illustration, and is not intended to limit the present application to the specific structures, devices and environments. According to specific needs, those skilled in the art can adjust or modify these devices and environments. DETAILED DESCRIPTION

[0045] The present application will be described in detail below with reference to the drawings and specific embodiments. It should be noted that in order to make the embodiments more detailed, the following embodiments are the best, preferred embodiments, and other alternative ways can also be used by those skilled in the art to implement some known technologies; and the drawings are only used to more specifically describe the embodiments, and are not intended to specifically limit the present application.

[0046] It should be noted that in the specification, "one embodiment", "embodiment", "exemplary embodiment", "some embodiments" and the like indicate that the described embodiments can include a specific feature, structure or property, but not necessarily every embodiment includes the specific feature, structure or property. In addition, when a specific feature, structure or property is described in combination with an embodiment, it should be within the knowledge of those skilled in the related art to implement such a feature, structure or property in combination with other embodiments (whether or not explicitly described).

[0047] Generally, the terms can be understood at least in part from the context in which they are used. For example, depending on the context, the term "one or more" as used herein can be used to describe any feature, structure, or characteristic in the singular or can be used to describe combinations of features, structures, or characteristics, whether large or small, whether related or unrelated to each other. In addition, the term "based on" can be understood as not necessarily intending to convey a set of exclusive factors, but can instead, at least in part, depending on the context, allow the presence of other factors not necessarily explicitly described.

[0048] It is to be understood that the terms "on", "over", and "above" in the present application should be interpreted in the broadest context to mean not only "directly on" something but also to include the meaning of being "on" something with intervening features or layers therebetween, and not only "over" or "above" something but also to include the meaning of being "over" or "above" something with no intervening features or layers therebetween.

[0049] In addition, spatially relative terms, such as "under", "below", "lower", "over", "upper" and the like, can be used herein for ease of description to describe one element or feature's relationship to another element(s) or feature(s) as illustrated in the figures. The spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientations depicted in the figures. The devices can be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein can similarly be interpreted accordingly.

[0050] As shown in Figures 1 to 10 The embodiment of the present application provides a device for constructing intervertebral disc degeneration model by using mouse simulation, which comprises a mounting base plate 1, a support rod 2 is fixedly connected to the middle of the top of the mounting base plate 1 in 2*2 arrangement, a top seat 3 is fixedly connected to the top of the support rod 2, a ring seat 4 is fixedly connected to the inner side of the top seat 3, a body clamping mechanism 5 is fixedly connected to the inside of the ring seat 4, and a fixing frame 6 is fixedly connected to the outer side of the ring seat 4 in annular arrangement, and four limb positioning mechanisms 7 are fixedly connected to the top of the fixing frame 6.

[0051] The four limb positioning mechanisms 7 comprise a fixed plate 71, the fixed plate 71 is installed on the top outer end of the fixing frame 6 through screws, an arc displacement assembly 72 is fixedly connected to the top of the fixed plate 71, an angle adjusting assembly 73 is fixedly connected to the top of the arc displacement assembly 72, a linear displacement assembly 74 is fixedly connected to the top of the angle adjusting assembly 73, and a positioning assembly 75 is fixedly connected to the inner end of the linear displacement assembly 74, the support rods 2 arranged in 2*2 on the base plate 7241 provide stable support for the whole device, so that shaking does not occur during the experiment, the top seat 3 at the top is firmly connected with the support rod 2, the ring seat 4 at the inner side provides a mounting position for the body clamping mechanism 5, so that the body of the mouse can be stably clamped, and the fixing frames 6 arranged in annular arrangement at equal intervals on the outer side of the ring seat 4 provide a solid foundation for the four limb positioning mechanisms 7.

[0052] The fixed plate 71 in the limb positioning mechanism 7 is installed on the top outer end of the fixed frame 6 by screws, ensuring the firmness of the connection. The arc-shaped displacement assembly 72 thereon can realize the arc-shaped displacement adjustment of the mouse limbs, enabling the limbs to move flexibly at different angles, better simulating the activities in the natural state. The angle adjustment assembly 73 can further adjust the angle of the limbs, meeting different experimental requirements. The linear displacement assembly 74 can accurately control the position of the limbs, realizing linear displacement adjustment. The positioning assembly 75 can firmly fix the mouse limbs, ensuring that no displacement occurs during the experiment.

[0053] Overall, the device can provide precise, stable and flexible experimental conditions for simulating the construction of an intervertebral disc degeneration model using mice through the synergistic effect of each part, helping to improve the accuracy and reliability of the experiment and providing a powerful tool for in-depth study of the causes, incidence and pathological changes of intervertebral disc degeneration.

[0054] As shown in Figures 1 to 3 The top of the installation base plate 1 is provided with mounting holes 8 on both sides, and the mounting holes 8 are all set as countersunk holes. The outer corners of the base plate, the top seat 3 and the ring seat 4 are all set as arc-shaped. The mounting holes 8 on both sides of the top of the base plate 7241 are all set as countersunk holes, which has many advantages. The design of the countersunk holes makes the screw head sink into the hole when the device is installed, so it will not protrude from the surface of the base plate 7241, thereby avoiding the interference and potential danger that the screw head may cause to the surrounding environment. At the same time, this design makes the device more flat and stable after installation, reducing the shaking or instability factors that may be caused by the protruding screw head.

[0055] In addition, the outer corners of the base plate 7241, the top seat 3 and the ring seat 4 are all set as arc-shaped, which also has many advantages. On the one hand, the arc-shaped outer corners improve the safety of the device, and personnel are less likely to be cut by sharp corners during operation, reducing the probability of accidents. On the other hand, this design enhances the aesthetics of the device to some extent, making its appearance more smooth and natural. Moreover, the arc-shaped outer corners are also more convenient during transportation and installation, and are less likely to scratch other objects or cause damage to themselves. At the same time, for mouse experiments using the device, the arc-shaped design also reduces the risk of injury to the mice, providing a safer experimental environment for the mice.

[0056] As shown in Figures 1 to 4 and Figures 7 to 10As shown, the arc-shaped displacement assembly 72 includes a support leg 721 fixedly connected to the top of the fixed plate 71, the top of the support leg 721 is fixedly connected with an arc-shaped frame 722, the inside of the arc-shaped frame 722 is slidably connected with an arc-shaped sliding block 723, one side of the arc-shaped sliding block 723 is fixedly connected with a drive group 724, the drive group 724 is connected with the arc-shaped frame 722, one side of the drive group 724 is connected with the bottom of the angle adjusting assembly 73, the drive group 724 includes a base plate 7241 and an arc-shaped rack 7242, the base plate 7241 is fixedly connected to the top of the arc-shaped sliding block 723, one side of the base plate 7241 close to the ring seat 4 is fixedly connected with a mounting arm 7243, the bottom of the mounting arm 7243 is fixedly connected with a first motor 7244, the output end of the first motor 7244 is fixedly connected with a gear 7245 penetrating through the mounting arm 7243, the arc-shaped rack 7242 is fixedly connected to one side of the arc-shaped frame close to the ring seat 4, the gear 7245 is meshedly connected with the arc-shaped rack 7242, one side of the base plate 7241 is connected with the angle adjusting assembly 73, the support leg 721 stably fixes the arc-shaped frame 722 on the top of the fixed plate 71, providing firm support for the whole assembly, the arc-shaped sliding block 723 inside the arc-shaped frame 722 can slide smoothly, ensuring the stability of movement, and the setting of the drive group 724 realizes the precise control of the arc-shaped sliding block 723.

[0057] The base plate 7241 in the drive group 724 provides a stable mounting position for the mounting arm 7243 and the first motor 7244, after the first motor 7244 is started, the output end drives the gear 7245 to rotate, and since the gear 7245 is meshedly connected with the arc-shaped rack 7242, the arc-shaped sliding block 723 can be accurately displaced along the inside of the arc-shaped frame 722, this design can provide a stable and adjustable arc-shaped movement trajectory for the part connected with the angle adjusting assembly 73, thereby better simulating the possible arc-shaped movement of the mouse's limbs in a natural state, helping to more realistically construct the intervertebral disc degeneration model.

[0058] This arc-shaped displacement design not only improves the accuracy and reliability of the experiment, but also enables the experimental personnel to flexibly adjust the position and movement trajectory of the mouse's limbs according to different experimental requirements, providing a powerful tool for in-depth study of the pathological process of intervertebral disc degeneration, at the same time, the precise mechanical structure design also guarantees the durability and stability of the device, which can maintain good performance in a long experimental process.

[0059] The angle adjusting assembly 73 comprises a connecting block 731 and a first hinged seat 732, the connecting block 731 is fixedly connected to the middle of the top of the base plate 7241, the first hinged seat 732 is fixedly connected to the bottom outer end of the base plate 7241, the top of the connecting block 731 is hinged with a second hinged seat 733, the top of the second hinged seat 733 is connected with the bottom of the linear displacement assembly 74, the base plate 7241 is hinged with a first electric push rod 734 through the first hinged seat 732, the outer end of the first electric push rod 734 is hinged with a third hinged seat 735, the top of the third hinged seat 735 is connected with the bottom outer end of the linear displacement assembly 74, and the linear displacement assembly 74 comprises a side rail 741, one end of the bottom of the side rail 741 close to the ring seat 4 and the top of the second hinged seat 733 are fixedly connected, the other end of the bottom of the side rail 741 away from the ring seat 4 is connected with the top of the third hinged seat 735, the outer end of the side rail 741 is fixedly connected with a second motor 742, the output end of the second motor 742 is fixedly connected with a unidirectional lead screw 743 penetrating through the side rail 741, the unidirectional lead screw 743 is rotationally connected to the inside of the side rail 741, the outer surface of the unidirectional lead screw 743 is threadedly connected with a sliding block 744, the outer side of the sliding block 744 is fixedly connected with a connecting arm 745, one end of the connecting arm 745 away from the second motor 742 is connected with the positioning assembly 75, in the angle adjusting assembly 73, the connecting block 731 is fixed in the middle of the top of the base plate 7241, thereby providing a stable connecting point for the second hinged seat 733, the first hinged seat 732 and the third hinged seat 735 are connected with the base plate 7241 and the bottom outer end of the linear displacement assembly 74 respectively, cooperating with the first electric push rod 734, thereby realizing flexible adjustment of the angle of the linear displacement assembly 74, and this design can accurately adjust the angle of the mouse limbs according to experimental requirements, better simulates the body posture under different conditions, and is helpful for more comprehensive research on the pathological process of intervertebral disc degeneration.

[0060] The side rail 741 of the linear displacement assembly 74 is connected with the angle adjusting assembly 73 through the second hinged seat 733 and the third hinged seat 735, thereby ensuring the stability of the overall structure, the second motor 742 at the outer end of the side rail 741 drives the unidirectional lead screw 743 to rotate, so that the threadedly connected sliding block 744 can move accurately inside the side rail 741, and the connecting arm 745 at the outer side of the sliding block 744 is connected with the positioning assembly 75, thereby realizing linear adjustment of the position of the mouse limbs, and this linear displacement function can accurately control the stretching degree and position of the mouse limbs, thereby providing more accurate data support for experiments.

[0061] Overall, the synergistic effect of the angle adjustment assembly 73 and the linear displacement assembly 74 enables precise adjustment of the mouse limbs at multiple angles and orientations, improving the flexibility and accuracy of the experiment, providing a powerful tool for in-depth study of intervertebral disc degeneration. At the same time, the precise mechanical structure design ensures the reliability and durability of the device, which can maintain good performance during long-term experiments.

[0062] The positioning assembly 75 includes a rotating shaft 751 rotatably connected to the inner end of the connecting arm 745 away from the second motor 742, and a positioning square frame 752 fixedly connected between the inner sides of the rotating shaft 751. The top of the positioning square frame 752 is screw-connected with a hand-screwed screw 753, and the end of the hand-screwed screw 753 is rotatably connected with a clamping plate 754 penetrating the positioning square frame 752. The rotating shaft 751 in the positioning assembly 75 is connected to the inner end of the connecting arm 745 away from the second motor 742, so that the positioning square frame 752 can rotate flexibly. This design is of great significance in practical application. When the position and angle of the mouse limbs need to be adjusted, the positioning square frame 752 can be adaptively rotated to avoid unnecessary distortion and damage to the mouse limbs.

[0063] The positioning square frame 752 is a key part for fixing the mouse limbs, and its structure design is reasonable. The hand-screwed screw 753 at the top is convenient to operate. By rotating the hand-screwed screw 753, the clamping plate 754 at the end can move up and down in the positioning square frame 752. When fixing the mouse limbs, the operator can easily adjust the position of the clamping plate 754 according to the size and shape of the mouse limbs, to ensure that the mouse limbs are firmly fixed in the positioning square frame 752, preventing the limbs from shifting during the experiment, thereby ensuring the accuracy and reliability of the experiment.

[0064] In addition, this positioning assembly 75 design is simple and practical, not only easy to operate, but also can adapt to different sizes of mice, improving the versatility of the device. In the construction experiment of intervertebral disc degeneration model, the stable and reliable positioning assembly 75 provides a strong guarantee for the smooth progress of the experiment, which helps researchers more accurately study the pathological mechanism of intervertebral disc degeneration.

[0065] As Figures 1 to 6As shown, the body clamping mechanism 5 includes a mounting base 51 fixedly connected to the inner bottom of the ring seat 4, the inner middle part of the mounting base 51 is fixedly connected with a second electric push rod 52, the top of the second electric push rod 52 is fixedly connected with a clamping assembly 53, the clamping assembly 53 includes a receiving plate 531 fixedly connected to the top of the second electric push rod 52, the middle part of the receiving plate 531 is fixedly connected with a guide rail 532, one end of the guide rail 532 is fixedly connected with a third motor 533, the output end of the third motor 533 is fixedly connected with a bidirectional screw rod 534 penetrating through the guide rail 532, the two ends of the bidirectional screw rod 534 are oppositely threaded, the bidirectional screw rod 534 is rotationally connected to the inside of the guide rail 532, the two ends of the bidirectional screw rod 534 are both threadedly connected with a displacement block 535, the top of the displacement block 535 is fixedly connected with a clamping arm 536, the outer end side of the clamping arm 536 is arranged in a semicircular shape, the positioning assembly 75 further includes a supporting rod 755 fixedly connected to the top of both sides of the clamping plate 754, the top of the supporting rod 755 penetrates through the positioning square frame 752, the bottom of the clamping plate 754 and the inner bottom of the positioning square frame 752 are both fixedly connected with a toothed anti-skid plate 756, the toothed anti-skid plate 756 is made of silica gel material, the mounting base 51 is fixed on the inner bottom of the ring seat 4, which provides stable support for the whole body clamping mechanism 5, the second electric push rod 52 in the middle part of the inner side of the mounting base 51 can accurately control the height of the clamping assembly 53, so as to realize the expansion or bending adjustment of the mouse body, which is helpful to simulate different body states and better study the pathological process of intervertebral disc degeneration.

[0066] The receiving plate 531 in the clamping assembly 53 is connected to the top of the second electric push rod 52 to provide a mounting position for the guide rail 532, the third motor 533 drives the bidirectional screw rod 534 to rotate, and since the two ends of the screw rod are oppositely threaded, the displacement blocks 535 at the two ends can reciprocatingly slide in the guide rail 532, thereby driving the clamping arm 536 to realize accurate clamping of the mouse body, and the outer end side of the clamping arm 536 is arranged in a semicircular shape, which is more fitted to the shape of the mouse body and can provide more stable clamping effect,

[0067] The supporting rod 755 in the positioning assembly 75 provides support and guidance for the movement of the clamping plate 754, ensuring that the clamping plate 754 can stably move down, and the toothed anti-skid plate 756 on the inner bottom of the clamping plate 754 and the positioning square frame 752 is made of silica gel material, on the one hand, the soft silica gel material can avoid causing harm to the mouse when fixing the mouse limbs, while also providing good friction, ensuring that the mouse limbs are firmly fixed, on the other hand, the toothed design increases the anti-skid effect, further improving the stability of the fixation.

[0068] Overall, the design of the body clamping mechanism 5 and the positioning assembly 75 is reasonable and functional, providing reliable technical support for simulating the construction of an intervertebral disc degeneration model using mice, and improving the accuracy and operability of the experiment.

[0069] The workflow of the technical solution provided by the present application is as follows:

[0070] First, the body of the experimental animal is stably placed on the top of the receiving plate 531, and the third motor 533 is started to operate. The third motor 533 can powerfully drive the bidirectional screw rod 534 to rotate. During rotation, the bidirectional screw rod 534 can assist in driving the displacement block 535 to smoothly slide inside the guide rail 532. It is worth noting that the threads on both ends of the screw rod are opposite in direction. This design allows the bidirectional screw rod 534 to assist in driving the displacement blocks 535 at both ends of the screw rod to reciprocally displace and slide inside the guide rail 532 when the bidirectional screw rod 534 rotates. By precisely adjusting the reciprocating displacement and sliding of the displacement block 535, the clamping arm 536 can be assisted to reciprocally displace. At this time, by adjusting the reciprocating displacement of the clamping arm 536, the animal body placed on the top of the receiving plate 531 can be accurately positioned and clamped. During use, the second electric push rod 52 can be started to operate. When the second electric push rod 52 is extended, it can push the receiving plate 531 to move upwards, and the receiving plate 531 moving upwards can push the animal body to an unfolded state. When the second electric push rod 52 is retracted, it can pull the animal body to move downwards, which can make the animal body in a curved state. Overall, in combination with the four-limb positioning mechanism 7, the four limbs and lumbar vertebrae of the experimental animal can be flexibly adjusted and swung, greatly improving the adaptability of the device during experimental exploration.

[0071] By setting the four limbs positioning mechanism 7, the limbs of the experimental animal can be filled into the inside of the positioning box 752, and by twisting the hand screw 753, the clamping plate 754 can be driven to move down, and the supporting rod 755 can assist in supporting and guiding, so that the clamping plate 754 can stably move down; at this time, the two tooth-shaped anti-skid plates 756 are close to each other, and then the limbs of the animal filled into the inside of the positioning box 752 can be firmly fixed, since the tooth-shaped anti-skid plate 756 is made of silica gel, it is relatively soft, so it can stably clamp and position the limbs of the animal; after positioning the limbs of the animal, the second motor 742 can be started to drive the unidirectional screw rod 743 to rotate, and the unidirectional screw rod 743 rotates to drive the sliding block 744 to slide on the inside of the side rail 741, and the sliding block 744 slides to drive the connecting arm 745 to move, and the connecting arm 745 moves to pull and drive the positioning box 752 to move; by adjusting the displacement of the positioning box 752, different sizes of animals can be flexibly adapted, greatly improving the adaptation performance of the whole device during use, and during adjustment, since the shaft 751 is provided, the positioning box 752 can be self-adaptively rotated during adjustment, avoiding the occurrence of animal limb fracture, and the experimental animal can be better protected.

[0072] By setting the angle adjusting assembly 73 and the arc-shaped displacement assembly 72, when the limbs of the animal are fixed, the first motor 7244 can be started to operate, the first motor 7244 operates to drive the gear 7245 to rotate, the gear 7245 is meshed and connected with the arc-shaped rack 7242, the gear 7245 rotates to drive the arc-shaped sliding block 723 to slide in the inside of the arc-shaped frame 722, at this time, the arc-shaped sliding block 723 slides along the arc-shaped cavity of the arc-shaped frame 722, and then the positioning box 752 is driven to arc-shapedly displace, which can assist in flexibly adjusting the reciprocating transverse swinging of the limbs of the animal, and during swinging, the first electric push rod 734 can be operated, the first electric push rod 734 operates to assist in pushing the side rail 741 to rotate and displace, at this time, the first hinged seat 732, the second hinged seat 733, the third hinged seat 735 and the connecting block 731 are linked and rotated, and then the side rail 741 is flexibly adjusted and driven to rotate, the rotation of the side rail 741 adjusts and drives the side rail 741 of the linear displacement assembly 74 to adjust the angle, the angle of the linear displacement assembly 74 is adjusted, the stroke of the linear displacement assembly 74 is changed, at this time, the limbs of the animal can be adjusted to move up and down, which can further improve the convenience of the whole device during use, and after the limbs of the animal are positioned, the whole animal can flexibly swing and displace in any direction, which can greatly improve the adjustment and adaptation performance of the whole device during lumbar spine pathological research.

[0073] The present application encompasses any alternatives, modifications, equivalent methods and solutions made to the essence and scope of the present application. In order to make the public have a thorough understanding of the present application, specific details are described in the following preferred embodiments of the present application, and the present application can also be fully understood without the description of these details to those skilled in the art. In addition, in order to avoid unnecessary confusion to the essence of the present application, well-known methods, processes, procedures, elements and circuits, etc. are not described in detail.

[0074] The above is only the preferred embodiment of the present application, and it should be pointed out that for ordinary skilled in the art, without departing from the principles of the present application, a number of improvements and refinements can also be made, which should be considered as the protection scope of the present application.

Claims

1. An apparatus for constructing a model of intervertebral disc degeneration using a mouse, characterized by comprising: The application relates to a four-limb positioning device. The four-limb positioning device comprises a fixed plate, a support leg, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a mounting arm, a first motor, a gear, an arc-shaped rack, a base plate, a ​ ​ ​ ​ ​ 2. The device for constructing an intervertebral disc degeneration model using a mouse simulation according to claim 1, wherein, ​ 3. The device for constructing an intervertebral disc degeneration model using a mouse simulation according to claim 1, wherein, The positioning assembly includes a rotating shaft, the rotating shaft is rotatably connected to the inner end of the connecting arm away from the second motor, the inner side of the rotating shaft is fixedly connected with a positioning square box, the top of the positioning square box is threadedly connected with a hand screw, the end of the hand screw is rotatably connected with a clamping plate through the positioning square box.

4. The device for constructing an intervertebral disc degeneration model using a mouse simulation according to claim 1, wherein, The body clamping mechanism includes a mounting base, the mounting base is fixedly connected to the inner bottom of the ring seat, the inner middle part of the mounting base is fixedly connected with a second electric push rod, the top of the second electric push rod is fixedly connected with a clamping assembly.

5. The device for constructing an intervertebral disc degeneration model using a mouse simulation according to claim 4, wherein, The clamping assembly includes a receiving plate, the receiving plate is fixedly connected to the top of the second electric push rod, the middle part of the receiving plate is fixedly connected with a guide rail, one end of the guide rail is fixedly connected with a third motor, the output end of the third motor is fixedly connected with a bidirectional screw rod through the guide rail, the thread rotation directions of the two ends of the bidirectional screw rod are opposite, the bidirectional screw rod is rotatably connected to the inside of the guide rail, the two ends of the bidirectional screw rod are both threadedly connected with a displacement block, the top of the displacement block is fixedly connected with a clamping arm, the outer end side of the clamping arm is semi-arc-shaped.

6. The device for constructing an intervertebral disc degeneration model using a mouse simulation according to claim 3, wherein, The positioning assembly further includes a support rod, the support rod is fixedly connected to the top of the clamping plate on both sides, the top of the support rod penetrates through the positioning square box, the bottom of the clamping plate and the inner bottom of the positioning square box are both fixedly connected with a toothed anti-skid plate, the toothed anti-skid plate is made of silica gel material.

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