Blood analyzer and blood analysis method

Abstract

The invention discloses a blood analyzer and a blood analysis method, the time for a first detection module and a second detection module of the blood analyzer to detect a first to-be-detected sample is a first time period, and the time for a sampling module to add a second to-be-detected sample to a first reaction tank located at a sample adding position is a second time period. The first time period and the second time period are partially overlapped, so that the sampling module can add the second to-be-detected sample according to the waiting time of the first detection module and the second detection module during sample detection, and the detection speed during specific protein detection and blood routine detection is increased. Moreover, the plurality of first reaction tanks of the first detection module are arranged on the annular conveying mechanism along the circumferential direction, so that the annular conveying mechanism can rotate the plurality of first reaction tanks to a sample adding position according to a periodic rule, and the plurality of first reaction tanks share the positions of the sampling module and the like, the complexity of the blood analyzer is simplified, and the stability of the blood analyzer is improved.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a blood analyzer and a blood analysis method. Background Art

[0002] Existing blood analyzers are usually equipped with multiple detection channels to obtain test parameters of multiple test items through samples in one sample tube, thereby reducing detection costs and increasing detection speed. For example, a blood analyzer is integrated with a second detection module for performing routine blood tests and a first detection module for performing specific protein tests. In order to increase the detection speed of the instrument, multiple first reaction pools are usually set up to perform specific protein tests. However, each first reaction pool needs to be equipped with an optical detection mechanism, a cleaning mechanism, a drainage mechanism, etc. adapted thereto, which increases the control difficulty during the sample detection process.

[0003] In addition, the sampling module of the blood analyzer obtains the sample to be tested by using a sample needle and distributes the sample to be tested to different modules. Since the multiple first reaction pools of the first detection module are complexly distributed, it takes a long time for the sampling module to distribute the sample to be tested to the first detection module and the second detection module, which limits the detection speed of the blood analyzer. Summary of the invention

[0004] In order to solve the above technical problems, the present application provides a blood analyzer and a blood analysis method.

[0005] In order to solve the above problems, the present application provides a blood analyzer, which includes a first detection module, a second detection module and a sampling module. The first detection module is used to perform a specific protein test on a first sample to be tested, and the first detection module includes an annular conveying mechanism, and the annular conveying mechanism is provided with a plurality of first reaction pools along the circumference, and the annular conveying mechanism is used to rotate the plurality of first reaction pools to the sample adding position in sequence; the second detection module is used to perform a routine blood test on the first sample to be tested; the sampling module is used to obtain the first sample to be tested, and add the first sample to be tested to the first detection module and the second detection module respectively; wherein, the time for the first detection module and the second detection module to detect the first sample to be tested is a first time period, and the time for the sampling module to add the second sample to be tested to the first reaction pool located at the sample adding position is a second time period, and the first time period and the second time period partially overlap.

[0006] Optionally, the annular conveying mechanism rotates in a preset rotation cycle, and pauses after rotating a preset step length in each rotation cycle, so that one of the plurality of first reaction pools is at the sample loading position and receives the sample to be tested.

[0007] Optionally, the first reaction pool includes a first sub-pool and a second sub-pool, the first sub-pool and the second sub-pool are used to test different specific protein detection items, the sampling module adds the second sample to be tested to the first sub-pool and the second sub-pool for a third time period, and the first time period and the third time period partially overlap.

[0008] Optionally, the second detection module includes multiple second reaction pools, the sample loading position and the multiple second reaction pools are arranged in parallel along the first direction, and the sampling module is used to move along the first direction and perform sample transfer operations; wherein the movement trajectory of the sampling module and the arrangement trajectory of the multiple first reaction pools on the annular conveying mechanism have at least one intersection point.

[0009] Optionally, the sampling module is provided with a sample suction position, and the sampling module is used to obtain the sample to be tested from the sample suction position. The time for the sampling module to perform sample transfer operation between the sample suction position and the second reaction pool is a fourth time period, and the fourth time period partially overlaps with the first time period.

[0010] Optionally, the first detection module includes multiple working positions and an optical detection mechanism, the multiple working positions are arranged along the circumference of the annular conveying mechanism, the working positions include a sample loading position and a detection position, and the optical detection mechanism is arranged corresponding to the detection position; wherein, during the rotation of the annular conveying mechanism in each rotation cycle, a first reaction pool stops at the detection position, and the optical detection mechanism is used to collect the sample reaction status of the first reaction pool at the detection position.

[0011] Optionally, the working position also includes a reagent adding position, and during the rotation of the annular conveying mechanism in each rotation cycle, a first reaction pool stops at the reagent adding position and is used to receive the detection reagent; wherein the detection reagent includes a first reagent and a second reagent with different components, and the first reaction pool at the reagent adding position is used to simultaneously receive the first reagent and the second reagent in each rotation cycle, or, the first reaction pool at the reagent adding position is used to respectively receive the first reagent and the second reagent in different rotation cycles.

[0012] Optionally, the first detection module includes a mixing mechanism, and the working position also includes a mixing position. The mixing mechanism and the mixing position are arranged correspondingly. During the rotation of the annular conveying mechanism in each rotation cycle, a first reaction pool stops at the mixing position, and the mixing mechanism is used to mix the detection reagent and the sample to be tested in the first reaction pool; and / or, the working position also includes a cleaning position. During the rotation of the annular conveying mechanism in each rotation cycle, a first reaction pool stops at the cleaning position, and the first reaction pool on the cleaning position is used to receive the cleaning reagent.

[0013] Optionally, the sample adding position, cleaning position, reagent adding position, mixing position and detection position are arranged on the circular conveying mechanism in a preset clockwise direction; wherein the circular conveying mechanism rotates 4 times and stops 3 times in each rotation cycle, and the circular conveying mechanism advances one position after each rotation cycle.

[0014] To solve the above problems, the present application provides a blood analysis method, which is applied to a blood analyzer. The blood analyzer includes a first detection module, a second detection module and a sampling module. The first detection module includes a ring-shaped conveying mechanism and a plurality of first reaction pools. The blood analysis method includes: controlling the ring-shaped conveying mechanism to rotate a first reaction pool to a sample adding position; controlling the sampling module to obtain a first sample to be tested, and adding the first sample to be tested to the first reaction pool and the second detection module at the sample adding position, respectively; while controlling the first detection module and the second detection module to detect the first sample to be tested, controlling the sampling module to add the second sample to be tested to the first reaction pool at the sample adding position.

[0015] The present application provides a blood analyzer and a blood analysis method, the blood analyzer includes a first detection module, a second detection module and a sampling module, the time for the first detection module and the second detection module to detect the first sample to be tested is a first time period, the time for the sampling module to add the second sample to be tested to the first reaction pool located at the sample loading position is a second time period, the first time period and the second time period partially overlap, so that the sampling module can use the waiting time when the first detection module and the second detection module perform sample detection to add the second sample to be tested, thereby improving the detection speed during specific protein detection and blood routine detection. In addition, the multiple first reaction pools of the first detection module are circumferentially arranged on the annular transmission mechanism, so that the annular transmission mechanism can rotate the multiple first reaction pools to the sample loading position according to a periodic law, and the multiple first reaction pools share the sampling module and other positions, which simplifies the complexity of the blood analyzer and improves the stability of the blood analyzer. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work. Among them:

[0017] Figure 1 It is a structural schematic diagram of an embodiment of a blood analyzer provided by the present application;

[0018] Figure 2 is a structural schematic diagram of another embodiment of the blood analyzer provided by the present application;

[0019] Figure 3 It is a flow chart of an embodiment of the blood analysis method provided by the present application;

[0020] Figure 4 It is a flow chart of another embodiment of the blood analysis method provided by the present application. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0022] It should be noted that if the embodiments of the present application involve directional indications (such as up, down, left, right, front, back...), the directional indications are only used to explain the relative position relationship, movement status, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

[0023] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the present application, the descriptions of "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or suggesting their relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such combination of technical solutions does not exist and is not within the scope of protection required by this application.

[0024] See also Figure 1 , Figure 1 FIG. 1 is a schematic diagram of the structure of an embodiment of a blood analyzer provided by the present application. Figure 1 As shown, in this embodiment, the blood analyzer includes a first detection module 11 , a second detection module 12 and a sampling module 13 .

[0025] The first detection module 11 is used to perform a specific protein test on the first sample to be tested. Specifically, the first detection module 11 includes an annular conveying mechanism 111, and the annular conveying mechanism 111 is provided with a plurality of first reaction pools 113 along the circumference, and the annular conveying mechanism 111 is used to rotate the plurality of first reaction pools 113 to the sample loading position in sequence. Specifically, the annular conveying mechanism 111 may include a turntable, a driving motor and other structures, and a plurality of first reaction pools 113 are provided on the turntable, and the first reaction pools 113 are used to accommodate solutions such as samples to be tested and reagents. In an optional embodiment, the first reaction pool 113 may also be provided with a side wall that can transmit detection light, and the first detection module 11 also includes an optical detection mechanism 112, and the optical detection mechanism 112 is provided on the conveying track of the annular conveying mechanism 111, so that the optical detection mechanism 112 can perform optical detection on the sample solution in the first reaction pool 113 passing through to obtain a specific protein detection result.

[0026] The second detection module 12 is used to perform a routine blood test on the first sample to be tested. Optionally, the second detection module 12 may include a plurality of second reaction pools 121, each of which may be used to perform the same or different detection items, for example, the plurality of second reaction pools 121 may be used to perform a test of at least one detection item such as red blood cell count (RBC), hemoglobin concentration (HGB), white blood cell count (three-classification or five-classification), and reticulocyte count (RET).

[0027] The sampling module 13 is used to obtain the first sample to be tested, and add the first sample to be tested to the first detection module 11 and the second detection module 12 respectively. Optionally, the sampling module 13 may include a sample needle and a motion mechanism, and the motion mechanism is used to drive the sample needle to move in a first direction and a second direction, wherein the first direction is perpendicular to the second direction, and the second direction is parallel to the gravity direction. The sample needle is used to move in the first direction and schedule the sample transfer between the first detection module 11 and the second detection module 12.

[0028] The time for the first detection module 11 and the second detection module 12 to detect the first sample to be tested is the first time period, and the time for the sampling module 13 to add the second sample to be tested to the first reaction pool 113 located at the sample adding position is the second time period, and the first time period and the second time period partially overlap. Specifically, the first time period is the time range spent by the first detection module 11 and the second detection module 12 to detect the first sample to be tested. For example, the first time period may include the time spent by the first detection module 11 and the second detection module 12 to perform the processes of adding reagents, mixing samples, incubating samples, and detecting the first sample to be tested. The second time period is the time range spent by the sampling module 13 to add the second sample to be tested to the first reaction pool 113 located at the sample adding position. For example, the second time period may include the time spent by the sample needle of the sampling module 13 to absorb the second sample to be tested from the sample tube or the sample suction position, the sampling module 13 to move from the sample suction position to the sample adding position, and the sampling module 13 to arrive at the sample adding position and perform the sample adding operation on the first reaction pool 113.

[0029] For example, the first detection module 11 detects the first sample to be tested at the time node A1, and the second detection module 12 detects and completes the first sample to be tested at the time node A2, and the first time period is [A1, A2]; the time node when the sampling module 13 obtains the second sample to be tested from the sample suction position is A3, the time node when the sampling module 13 arrives at the sample addition position and adds the second sample to be tested to the first reaction pool 113 is A4, and the second time period is [A3, A4]. The first time period and the second time period partially overlap, that is, the A3 time node or the A4 time node can be performed at least within the first time period, or the A1 time node or the A2 time node can be performed at least within the second time period. For another example, while the first detection module 11 and / or the second detection module 12 detect the first sample to be tested, the sampling module 13 performs at least one operation of: sucking the second sample to be tested from the sample tube or the sample suction position, moving from the sample suction position to the sample addition position, and the sampling module 13 arriving at the sample addition position and adding the second sample to be tested to the first reaction pool 113.

[0030] Furthermore, the first sample to be tested and the second sample to be tested in this embodiment can be blood samples of the same test subject, or blood samples of different test subjects. For example, the first sample to be tested and the second sample to be tested can be samples obtained by splitting the same blood sample for testing different test items; or, the first sample to be tested and the second sample to be tested can be samples of different test subjects in the order of the test. In an optional embodiment, the first sample to be tested and the second sample to be tested can be original blood samples obtained through a blood sampling operation, or diluted samples obtained through a pre-dilution operation, which is not specifically limited here.

[0031] In the embodiment of the present application, the blood analyzer includes a first detection module 11, a second detection module 12 and a sampling module 13. The time for the first detection module 11 and the second detection module 12 to detect the first sample to be tested is a first time period, and the time for the sampling module 13 to add the second sample to be tested to the first reaction pool 113 located at the sample loading position is a second time period. The first time period and the second time period partially overlap, so that the sampling module 13 can use the waiting time when the first detection module 11 and the second detection module 12 perform sample detection to load the second sample to be tested, thereby improving the detection speed during specific protein detection and blood routine detection. In addition, the multiple first reaction pools 113 of the first detection module 11 are circumferentially arranged on the annular conveying mechanism 111, so that the annular conveying mechanism 111 can rotate the multiple first reaction pools 113 to the sample loading position according to a periodic law, and the multiple first reaction pools 113 share the sampling module 13 and other positions, which simplifies the complexity of the blood analyzer and improves the stability of the blood analyzer.

[0032] In one embodiment, the annular conveying mechanism 111 rotates in a preset rotation cycle and pauses after rotating a preset step length in each rotation cycle, so that one of the plurality of first reaction pools 113 is at the sample loading position and receives the sample to be tested.

[0033] Specifically, a plurality of workstations are arranged along the circumference of the annular conveyor mechanism 111, and a corresponding mechanism is arranged on each workstation for performing detection work such as reagent addition, sample mixing, cleaning, and detection on the first reaction pool 113 at the corresponding position. Since the annular conveyor mechanism 111 rotates in a preset rotation cycle, in each rotation cycle, the plurality of first reaction pools 113 are respectively located at different workstations and in different specific protein detection nodes, so that the first detection module 11 can test a plurality of samples to be tested at the same time, thereby improving the detection speed of specific proteins.

[0034] Further, the working position includes the above-mentioned sample loading position, and the annular conveyor mechanism 111 pauses after rotating the first preset step length in each rotation cycle, so that one of the multiple first reaction pools 113 is at the sample loading position and receives the sample to be tested. For example, the first reaction pool 113 may include a third sub-pool and a fourth sub-pool arranged in a preset clockwise order. When the annular conveyor mechanism 111 performs the first rotation cycle, the annular conveyor mechanism 111 pauses after rotating the preset step length, and the third sub-pool is located at the sample loading position to receive the first sample to be tested; after the third sub-pool receives the first sample to be tested, the annular conveyor mechanism 111 continues to perform the second rotation cycle. After the second rotation cycle ends, the annular conveyor mechanism 111 pauses after rotating the preset step length, and the fourth sub-pool is located at the sample loading position to receive the sample to be tested. That is, each rotation cycle of the annular conveyor mechanism 111 completes the loading of a first reaction pool 113, so that the rotation cycle of the annular conveyor mechanism 111 is related to the detection speed of the blood analyzer of this embodiment.

[0035] Optionally, the first reaction pool 113 includes a first sub-pool and a second sub-pool, and the first sub-pool and the second sub-pool are used to test different specific protein detection items. The sampling module 13 adds the second sample to be tested to the first sub-pool and the second sub-pool for a third time period, and the first time period and the third time period partially overlap.

[0036] Specifically, the third time period may include the time taken by the sampling module 13 to absorb the second sample to be tested from the sample suction position, the sampling module 13 to move from the sample suction position to the first sub-pool on the sample loading position and add the second sample to be tested to the first sub-pool, the sampling module 13 to wait for the annular conveying mechanism 111 to move the second sub-pool to the sample loading position, the sampling module 13 to add the second sample to be tested to the second sub-pool on the sample loading position, etc. While the first detection module 11 and / or the second detection module 12 are detecting the first sample to be tested, the sampling module 13 performs at least one of the above steps, so that the first time period and the third time period partially overlap, and the sampling module 13 can use the waiting time when the first detection module 11 and the second detection module 12 are performing sample detection to perform the specific protein loading of the second sample to be tested, thereby improving the detection speed during blood analysis.

[0037] Among them, the first subpool and the second subpool are used for testing different specific protein detection items. For example, the first subpool can be used to test one of the CRP (C-reactive protein) and SAA (serum amyloid A) items, and the second subpool is used to test the other of the CRP and SAA items.

[0038] Furthermore, while the sampling module 13 is waiting for the annular conveying mechanism 111 to move the second sub-pool to the sample adding position, the sampling module 13 can be used to execute the step of adding the second sample to be tested to the second detection module 12, thereby saving waiting time and improving the detection speed during blood analysis.

[0039] In one embodiment, the second detection module 12 includes a plurality of second reaction pools 121, the sample loading position and the plurality of second reaction pools 121 are arranged in parallel along a first direction, and the sampling module 13 is used to move along the first direction and perform sample transfer operations; wherein, the movement trajectory of the sampling module 13 and the arrangement trajectory of the plurality of first reaction pools 113 on the annular conveying mechanism 111 have at least one intersection point, and the intersection position of the movement trajectory of the sampling module 13 and the arrangement trajectory of the plurality of first reaction pools 113 on the annular conveying mechanism 111 coincides with the sample loading position, so that the sampling module 13 can load samples to the first reaction pool 113 and the second reaction pool 121 in one loading sequence.

[0040] Specifically, the plurality of second reaction pools 121 of the second detection module 12 are arranged in parallel along the first direction, and each second reaction pool 121 can provide a reaction site for samples of different blood routine test items. In an optional embodiment, the sampling module 13 is provided with a sample suction position, and the sampling module 13 is used to obtain the sample to be tested from the sample suction position. At this time, the sample suction position, the sample addition position, and the plurality of second reaction pools 121 are all arranged linearly along the first direction, so that the sampling module 13 can only perform sample scheduling in the first direction, reducing the time spent by the sample needle on the path movement when multiple scheduling directions are used. In addition, the sampling module 13 can perform sample addition of the second detection module 12 after performing the sample addition of the first detection module 11 (or perform sample addition of the first detection module 11 after performing the sample addition of the second detection module 12), improve the scheduling efficiency of the sampling module 13, further reduce the time for the sample needle to perform sampling and sub-sampling, and improve the efficiency of blood analysis.

[0041] Optionally, the sampling module 13 is provided with a sample suction position, and the sampling module 13 is used to obtain the sample to be tested from the sample suction position. The time for the sampling module 13 to perform sample transfer operation between the sample suction position and the second reaction pool 121 is a fourth time period, and the fourth time period partially overlaps with the rotation period.

[0042] Specifically, the sample transfer operation performed by the sampling module 13 between the sample suction position and the second reaction pool 121 may include the steps of the sampling module 13 sucking the sample to be tested at the sample suction position, the sampling module 13 moving from the sample suction position to the second reaction pool 121 to be added, and the sampling module 13 adding the sample to be tested to the second reaction pool 121. The time period for the sampling module 13 to perform the above steps is the fourth time period. The fourth time period partially overlaps with the rotation period, that is, at least one of the above steps occurs within the rotation period.

[0043] There is a stop sequence in each rotation cycle of the annular conveyor mechanism 111, in which the sampling module 13 adds the sample to be tested to the first reaction pool 113 on the sample adding position. In a possible implementation, when the sampling module 13 moves from the sample suction position to the second reaction pool 121, the sampling module 13 arrives at the sample adding position and the rotation cycle enters the stop sequence. At this time, the sampling module 13 can directly add the sample to be tested to the first reaction pool 113; in the rotation cycle except the stop sequence, the sampling module 13 can perform other steps of the above steps, so as to use the annular conveyor mechanism 111 to move the next first reaction pool 113 to be loaded with samples to the sample adding position to perform the sample loading operation and / or sample suction operation of the second detection module 12, so that the speed of the blood analyzer of this embodiment for blood routine detection and specific protein detection is limited by the time taken by the annular conveyor mechanism 111 to complete the test of a sample to be tested (including the steps of loading, adding reagents, mixing, etc.) in multiple rotation cycles, that is, the detection speed of the blood analyzer can be measured by the rotation cycle of the annular conveyor mechanism 111.

[0044] Optionally, the first detection module 11 includes multiple working positions and an optical detection mechanism 112, and the multiple working positions are arranged along the circumference of the annular conveying mechanism 111. The working positions include a sample loading position and a detection position, and the optical detection mechanism 112 is arranged corresponding to the detection position; wherein, during the rotation of the annular conveying mechanism 111 in each rotation cycle, a first reaction pool 113 stops at the detection position, and the optical detection mechanism 112 is used to collect the sample reaction status of the first reaction pool 113 at the detection position.

[0045] Specifically, in each rotation cycle, the annular conveying mechanism 111 enters a stop sequence after traveling the second preset step length, so that a certain first reaction pool 113 stops at the detection position, at which time, the optical detection mechanism 112 is used to collect the sample reaction state of the first reaction pool 113 at the detection position. The optical detection mechanism 112 may include a light emitter and a light receiver arranged opposite to each other, the light emitter is used to emit a detection light beam to the first reaction pool 113 at the detection position, the detection light beam passes through the side wall of the first reaction pool 113 and irradiates the sample to be tested, and the light receiver is used to receive the light transmittance of the sample to be tested in the first reaction pool 113 on the opposite side, so as to perform a specific protein test on the sample to be tested according to the light transmittance and obtain the test result.

[0046] In an optional embodiment, after a preset number of rotation cycles of the annular conveying mechanism 111, a first reaction pool 113 among the plurality of first reaction pools 113 can complete the steps of adding samples to be tested, adding reagents, mixing samples, testing samples, and cleaning. In this process, in each rotation cycle, the optical detection mechanism 112 performs at least one optical detection on the first reaction pool 113 stopped at the detection position, so as to determine the sample reaction state of the sample to be tested in the first reaction pool 113 according to the threshold range of the acquired light transmittance intensity. The sample reaction state can include whether the sample and the reagent have reacted completely, so that the optical detection mechanism 112 can use the light transmittance intensity detected after the sample and the reagent have reacted completely as the detection result of the sample to be tested, thereby ensuring the accuracy of the specific protein detection.

[0047] Optionally, the working position further includes a reagent adding position, and during the rotation of the annular conveying mechanism 111 in each rotation cycle, a first reaction pool 113 stops at the reagent adding position and is used to receive the detection reagent.

[0048] Wherein, the detection reagent includes a first reagent and a second reagent with different components, for example, the first reagent and the second reagent can be reagents required for detection such as diluents, hemolytic agents, etc. The first detection module 11 also includes a reagent mechanism, and the reagent mechanism is arranged corresponding to the reagent position. In an optional embodiment, the reagent mechanism may include a reagent needle and a reagent storage tank connected to the reagent needle, and the reagent storage tank may be connected to a pressure source, so as to drive the reagent in the reagent storage tank to be transported to the reagent needle by the pressure provided by the pressure source, and the reagent needle is used to add a quantitative reagent to the first reaction pool 113 of the reagent position. In other embodiments, the reagent mechanism may include a transmission pipeline and a reagent storage mechanism connected to the input port of the transmission pipeline, and the output port of the transmission pipeline is located above the first reaction pool 113 of the reagent position, and when the transmission pipeline is connected, the reagent storage mechanism can directly add the reagent to the first reaction pool 113 through the transmission pipeline, so as to realize the addition of the first reagent and / or the second reagent.

[0049] Specifically, the first reagent and the second reagent can be added in the stop sequence of the same rotation cycle, or can be added separately in different rotation cycles. Exemplarily, in one embodiment, before or after a certain first reaction pool 113 adds a sample to be tested, the annular conveyor mechanism 111 enters a stop sequence after traveling a third preset step length, and a certain first reaction pool 113 stops at the reagent position, so that the reagent mechanism adds the first reagent and the second reagent into the first reaction pool 113. That is, the first reaction pool 113 at the reagent addition position is used to simultaneously receive the first reagent and the second reagent in each rotation cycle. In another embodiment, before a certain first reaction pool 113 adds a sample to be tested, the annular conveyor mechanism 111 enters the first stop sequence after advancing the fourth preset step length, and the first reaction pool 113 stops at the reagent position and receives the first reagent; the annular conveyor mechanism 111 continues to advance the fifth preset step length and enters the second stop sequence, and the first reaction pool 113 stops at the sample adding position and receives the sample to be tested, at which time, the annular conveyor mechanism 111 completes a rotation cycle; the annular conveyor mechanism 111 continues to advance the fourth preset step length and enters the third stop sequence, and the first reaction pool 113 stops at the reagent position and receives the second reagent. That is, the first reaction pool 113 at the reagent adding position is used to receive the first reagent and the second reagent respectively in different rotation cycles.

[0050] It can be understood that in the above-mentioned embodiment, the method of the first reaction pool 113 on the reagent position simultaneously receiving the first reagent and the second reagent is simpler, which is convenient for designing the position and scheduling cycle of each work position, and reduces the design difficulty of the blood analyzer; the method of receiving the first reagent and the second reagent separately in different rotation cycles is more conducive to the uniform mixing of the reagents and samples; the user can adjust the detection process of the first detection module 11 according to actual usage requirements, and no specific limitation is made here.

[0051] Optionally, in one embodiment, the first detection module 11 includes a mixing mechanism, and the working position also includes a mixing position. The mixing mechanism and the mixing position are arranged correspondingly. During the rotation of the annular conveying mechanism 111 in each rotation cycle, a first reaction pool 113 stops at the mixing position. The mixing mechanism is used to mix the detection reagent and the sample to be tested in the first reaction pool 113.

[0052] Specifically, in one embodiment, the mixing mechanism may be provided with a mixing rod or a mixing gripper, and the mixing rod is used to extend into the first reaction pool 113 at the mixing position to stir and mix the sample liquid, or the annular conveying mechanism 111 is provided with a plurality of cup positions, and the reaction cup placed on each cup position serves as the first reaction pool 113, and the mixing gripper can be used to grab the reaction cup on the mixing position and oscillate and mix the sample liquid in the reaction cup. In another embodiment, the mixing position and the reagent adding position are the same working position. In this case, the mixing mechanism can be replaced by a reagent needle at the reagent adding position, and the sample liquid in the first reaction pool 113 is repeatedly sucked and discharged by the reagent needle, so that the first reagent, the second reagent and the sample to be tested are mixed during the sucking and discharging process, thereby achieving a mixing effect.

[0053] In another embodiment, the working position includes a cleaning position. During the rotation of the annular conveying mechanism 111 in each rotation cycle, a first reaction pool 113 stops at the cleaning position. The first reaction pool 113 at the cleaning position is used to receive the cleaning reagent.

[0054] In an optional embodiment, the first detection module 11 includes a cleaning mechanism, and the cleaning mechanism includes a cleaning needle and a cleaning liquid tank connected to the cleaning needle. The cleaning needle is arranged corresponding to the cleaning position, the cleaning liquid tank is used to store the cleaning liquid, and the cleaning needle is used to aspirate the sample liquid in the first reaction pool 113 on the cleaning position, and add a quantitative cleaning liquid to the first reaction pool 113 to clean the first reaction pool 113, so that the first reaction pool 113 after cleaning can be used for the detection of the next sample to be tested. In other embodiments, the cleaning position and the reagent addition position are the same working position. In this case, the cleaning needle can be replaced by the reagent needle of the reagent addition position, so that the sample liquid in the first reaction pool 113 on the cleaning position can be aspirated by the reagent needle and a quantitative cleaning liquid can be added.

[0055] In other embodiments, the annular conveyor mechanism 111 is provided with independent sample adding positions, cleaning positions, reagent adding positions, mixing positions, and detection positions, and each first reaction pool 113 can be moved to the above-mentioned working positions in sequence when the annular conveyor mechanism 111 rotates, so as to realize the corresponding workflow through other matching sample needles, reagent needles, cleaning needles, etc. In addition, the user can adjust the setting and scheduling of the working positions according to actual use requirements, which is not specifically limited here.

[0056] In the embodiment of the present application, the working position of the annular conveying mechanism 111 includes a mixing position and / or a cleaning position so that the sample to be tested and the reagent in the first reaction pool 113 are evenly mixed; and, by setting the cleaning position, the first reaction pool 113 after the detection can be suitable for the detection of the next sample to be tested, thereby reducing the cross contamination that may occur between different samples to be tested and improving the accuracy of specific protein detection.

[0057] Optionally, the sample adding position, the cleaning position, the reagent adding position, the mixing position and the detection position are arranged on the annular conveyor mechanism 111 in a preset clockwise direction; the annular conveyor mechanism 111 rotates 4 times and stops 3 times in each rotation cycle, and the annular conveyor mechanism 111 advances one position after each rotation cycle. The preset clockwise direction includes but is not limited to the clockwise direction and the counterclockwise direction.

[0058] For example, see Figure 2 , Figure 2 FIG. 1 is a schematic diagram of the structure of another embodiment of the blood analyzer provided by the present application. Figure 2 As shown, the sample adding position, cleaning position, reagent adding position, mixing position and detection position are arranged in the circular conveying mechanism 111 in a counterclockwise direction, and the number of the first reaction pools 113 corresponds to the number of working positions (i.e., 5 first reaction pools 113). At this time, the circular conveying mechanism 111 rotates 4 times and stops 3 times in each rotation cycle, and the step length during each rotation can be the same or different. The circular conveying mechanism 111 completes the detection of a sample to be tested after 5 rotation cycles. That is, the sample to be tested in a first reaction pool 113 completes the steps of sample adding, reagent adding, mixing, detection, and cleaning after 5 rotation cycles.

[0059] In one embodiment, the first detection module 11 completes the following detection steps when completing 5 rotation cycles: adding the first reagent to the first reaction pool 113, adding the sample to be tested to the first reaction pool 113, mixing the sample liquid in the first reaction pool 113 once, adding the second reagent to the first reaction pool 113, mixing the sample liquid in the first reaction pool 113 twice, performing optical detection on the sample liquid in the first reaction pool 113, cleaning the first reaction pool 113 once, and cleaning the second reaction pool 121 twice. At this time, the rotation sequence and stop sequence of the ring conveyor mechanism 111 in the 5 rotation cycles are shown in the following table:

[0060] Table 1: Schematic diagram of an embodiment of the rotation sequence of the annular transmission mechanism 111

[0061] Turn 3 Stop 1 Turn 4 Stop 2 Turn 1 Stop 3 Turn 3 Stop 4 Cycle 1 Add the first reagent - - Add samples to be tested Cycle 2 One-time mixing Add the second reagent Secondary mixing - Cycle 3 - - - - Cycle 4 - - - - Cycle 5 One-time cleaning - Secondary cleaning -

[0062] Specifically, Figure 2As shown, the annular conveyor mechanism 111 is provided with reaction pool 1, reaction pool 2, reaction pool 3, reaction pool 4, and reaction pool 5 in a counterclockwise direction, and reaction pool 1 is located at the sample adding position. When the first detection module 11 starts the test, the annular conveyor mechanism 111 rotates in the counterclockwise direction according to the preset speed, the annular conveyor mechanism 111 rotates 3 working positions and enters the stop sequence 1, and the reaction pool 2 stops at the reagent adding position and receives the first reagent; the annular conveyor mechanism 111 continues to rotate 4 working positions, enters the stop sequence 2, rotates 1 working position, enters the stop sequence 3, rotates 3 working positions and enters the stop sequence 4, at this time, the reaction pool 2 stops at the sample adding position and receives the sample to be tested transferred from the sampling module 13. The circular conveyor mechanism 111 rotates 3 working positions and enters stop sequence 1, and the reaction pool 2 stops at the mixing position to achieve a primary mixing of the sample to be tested and the first reagent; after the primary mixing is completed, the circular conveyor mechanism 111 rotates 4 working positions and enters stop sequence 2, and the reaction pool 2 stops at the reagent adding position to receive the second reagent; the circular conveyor mechanism 111 rotates 1 working position and enters stop sequence 3, and the reaction pool 2 stops at the mixing position to achieve a secondary mixing of the sample to be tested, the first reagent, and the second reagent. After the secondary mixing, it continues to rotate in the manner of the above table, and each time the reaction pool 2 stops at the detection position, the optical detection mechanism 112 detects the sample reaction state of the reaction pool 2. When the circular conveyor mechanism 111 rotates to the 5th rotation cycle, the circular conveyor mechanism 111 rotates 3 working positions and enters stop sequence 1, and the reaction pool 2 stops at the cleaning position and performs a cleaning; the circular conveyor mechanism 111 continues to rotate 4 working positions, enters stop sequence 2, rotates 1 working position, enters stop sequence 3, and the reaction pool 2 stops at the cleaning position and performs a second cleaning to improve the cleaning effect and reduce the possibility of sample residue in the reaction pool 2.

[0063] In another embodiment, the first detection module 11 completes the following detection steps when completing 5 rotation cycles: adding the first reagent and the second reagent into the first reaction pool 113, adding the sample to be tested into the first reaction pool 113, mixing the sample liquid in the first reaction pool 113, optically detecting the sample liquid in the first reaction pool 113, and cleaning the first reaction pool 113. At this time, the rotation sequence and stop sequence performed by the ring-shaped conveying mechanism 111 in the 5 rotation cycles are shown in Table 2.

[0064] Specifically, different from the previous embodiment, the present embodiment adds the first reagent and the second reagent at the same stop sequence of the first rotation cycle, so that only one mixing is required after adding the sample to be tested. The test process and scheduling method of the first detection module 11 are simpler, which is conducive to streamlining and adjusting the workstations. The specific rotation method is similar to the above and will not be repeated here.

[0065] Table 2: Schematic diagram of another embodiment of the rotation sequence of the annular transmission mechanism 111

[0066]

[0067] It can be understood that, since the first time period and the second time period of the blood analyzer of the present embodiment partially overlap, the sampling module 13 can use the waiting time when the first detection module 11 and the second detection module 12 perform sample detection to add the second sample to be tested, saving the waiting time of the first detection module 11 and the second detection module 12, and thus the detection speed of the blood analyzer of the present embodiment is limited by the sample suction and sample addition time of the sample needle. In addition, since the fourth time period partially overlaps with the rotation period, in each rotation period, before the annular conveying mechanism 111 moves the reaction pool 2 to the sample addition position, the sampling module 13 can be used to perform a sample transfer operation between the sample suction position and the second reaction pool 121, so as to save the sample suction time and the sample addition time of the second detection module 12. That is, the detection speed of the blood analyzer of the present embodiment is related to the sample addition time of the first detection module 11, and the detection speed of the blood analyzer can be measured by the rotation period of the annular conveying mechanism 111. For example, each rotation cycle of the annular conveying mechanism 111 takes 24 seconds, and each rotation cycle completes the addition of one sample to be tested, that is, the detection speed of the blood analyzer in this embodiment is 3600s / 24s=150, and the blood analyzer can complete the testing of 150 samples to be tested per hour.

[0068] See also Figure 3 , Figure 3 FIG. 1 is a flow chart of an embodiment of the blood analysis method provided by the present application. Figure 3 As shown, the blood analysis method comprises:

[0069] Step S11: controlling the annular conveying mechanism 111 to rotate a first reaction pool 113 to a sample loading position.

[0070] Specifically, the annular conveying mechanism 111 is controlled to rotate a first reaction pool 113 to be loaded with a sample to a sample loading position at a preset speed.

[0071] Step S12: controlling the sampling module 13 to obtain the first sample to be tested, and adding the first sample to be tested to the first reaction pool 113 and the second detection module 12 at the sample adding position respectively.

[0072] Specifically, the sampling module 13 is controlled to absorb a sufficient amount of the first sample to be tested from the sample tube on the sample aspirating position, and the first sample to be tested is added to the first reaction pool 113 and the second detection module 12 at the sample adding position respectively.

[0073] It can be understood that step S12 and step S11 can be performed simultaneously or crosswise. For example, in the process of controlling the annular conveying mechanism 111 to rotate a certain first reaction pool 113 to the sample adding position, the sampling module 13 is controlled to perform the steps of obtaining the first sample to be tested, moving from the sample suction position to the second detection module 12, adding the first sample to be tested to the second detection module 12, and moving from the second detection module 12 to the sample adding position; or, in the process of controlling the annular conveying mechanism 111 to rotate a certain first reaction pool 113 to the sample adding position, the sampling module 13 is controlled to perform the steps of obtaining the first sample to be tested, moving from the sample suction position to the sample adding position, so that after adding the first sample to be tested to the first reaction pool 113, the steps of adding the first sample to be tested to the second detection module 12 and moving from the second detection module 12 to the sample adding position are performed.

[0074] Step S13: while controlling the first detection module 11 and the second detection module 12 to detect the first sample to be detected, controlling the sampling module 13 to add the second sample to be detected to the first reaction pool 113 at the sample adding position.

[0075] Specifically, while controlling the first detection module 11 and the second detection module 12 to detect the first sample to be tested, the sampling module 13 is controlled to add the second sample to be tested to the first reaction pool 113 at the sample adding position. The first sample to be tested and the second sample to be tested can be blood samples of the same test subject, or blood samples of different test subjects. For example, the first sample to be tested and the second sample to be tested are test samples of the same test subject for different test items, or the first sample to be tested and the second sample to be tested are test samples of different test subjects in the detection sequence.

[0076] In the embodiment of the present application, since the first detection module 11 and the second detection module 12 are detecting the first sample to be tested, the sampling module 13 adds the second sample to be tested to the first reaction pool 113 at the sample loading position, so that the sampling module 13 can use the waiting time when the first detection module 11 and the second detection module 12 are performing sample detection to load the second sample to be tested, thereby saving the waiting time of the detection modules and improving the detection speed during specific protein detection and blood routine detection.

[0077] In one embodiment, see Figure 4 , Figure 4 FIG. 1 is a flow chart of another embodiment of the blood analysis method provided by the present application. Figure 4 As shown, the first reaction pool 113 includes a first sub-pool and a second sub-pool, and the blood analysis method may include the following steps:

[0078] Step S21: controlling the sampling module 13 to absorb the first sample to be tested at the sample aspirating position, and adding the first sample to be tested to the first sub-pool at the sample adding position.

[0079] Step S22: controlling the sampling module 13 to add the first sample to be tested to the second detection module 12, so that the second detection module 12 detects the first sample to be tested.

[0080] Step S23: while the second detection module 12 is detecting the first sample to be detected, the sampling module 13 is controlled to obtain the second sample to be detected, and the second sample to be detected is added to the second sub-pool on the sample adding position.

[0081] Specifically, in one embodiment, the plurality of first reaction pools 113 on the annular conveyor mechanism 111 are used to test the same specific protein detection item, and the second sample to be tested is the next sample to be tested after the detection timing of the first sample to be tested. At this time, since the first detection module 11 only needs to add the sample once to complete the test of a subject, when the annular conveyor mechanism 111 rotates according to the timing of Table 1 or Table 2, the detection speed of the blood analyzer is related to the time consumption of the rotation cycle, for example, each rotation cycle consumes 24s, and the detection speed of the blood analyzer is 3600s / 24s=150 / h.

[0082] In another embodiment, the plurality of first reaction pools 113 on the annular conveyor mechanism 111 are used to perform tests on different specific protein detection items, and the second test sample is a test sample of different detection items of the same test subject. At this time, since the first detection module 11 needs to be added multiple times to complete the test of a test subject, the detection speed of the blood analyzer is related to the time consumption of the rotation cycle and the number of specific protein detection items. For example, when the annular conveyor mechanism 111 rotates according to the timing of Table 1 or Table 2, the first detection module 11 is used to perform CRP+SAA test on the test sample, and each rotation cycle consumes 24s, and the detection speed of the blood analyzer is 3600s / 24s / 2=75 pieces / h.

[0083] Different from the prior art, the blood analyzer of the embodiment of the present application adjusts the working position setting, rotation cycle, test timing, etc. of the annular conveying mechanism 111 of the first detection module 11, so that the first time period partially overlaps with the second time period, thereby saving the waiting time when the first detection module 11 and the second detection module 12 perform detection; and when the fourth time period partially overlaps with the rotation cycle, the sample addition time of the first detection module 11 and the second detection module 12 partially overlaps, so as to reduce the time spent by the sample needle and the annular conveying mechanism 111 in the scheduling position, thereby effectively improving the detection speed during specific protein detection and blood routine detection.

[0084] The above description is only an implementation method of the present application, and does not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly used in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. A blood analyzer, characterized in that: include: A first detection module, used for performing a specific protein detection on a first sample to be tested, wherein the first detection module comprises an annular conveying mechanism, wherein the annular conveying mechanism is provided with a plurality of first reaction pools along a circumferential direction, and the annular conveying mechanism is used for sequentially rotating the plurality of first reaction pools to a sample loading position; A second detection module, used for performing a routine blood test on the first sample to be tested; A sampling module, used for acquiring the first sample to be tested, and adding the first sample to be tested to the first detection module and the second detection module respectively; The time for the first detection module and the second detection module to detect the first sample to be tested is a first time period, and the time for the sampling module to add the second sample to be tested to the first reaction pool located at the sample adding position is a second time period, and the first time period and the second time period partially overlap.

2. The blood analyzer according to claim 1, characterized in that: The annular conveying mechanism rotates in a preset rotation cycle and pauses after rotating a preset step length in each rotation cycle, so that one of the plurality of first reaction pools is located at the sample loading position and receives the sample to be tested.

3. The blood analyzer according to claim 2, characterized in that: The first reaction pool includes a first sub-pool and a second sub-pool, the first sub-pool and the second sub-pool are used to test different specific protein detection items, the sampling module adds the second sample to be tested to the first sub-pool and the second sub-pool for a third time period, and the first time period and the third time period partially overlap.

4. The blood analyzer according to claim 2, characterized in that: The second detection module comprises a plurality of second reaction pools, the sample adding position and the plurality of second reaction pools are arranged in parallel along a first direction, and the sampling module is used to move along the first direction and perform a sample transfer operation; Wherein, the movement trajectory of the sampling module and the arrangement trajectory of the plurality of first reaction pools on the annular conveying mechanism have at least one tangent point.

5. The blood analyzer according to claim 4, characterized in that: The sampling module is provided with a sample suction position, and the sampling module is used to obtain the sample to be tested from the sample suction position. The time for the sampling module to perform sample transfer operation between the sample suction position and the second reaction pool is a fourth time period, and the fourth time period partially overlaps with the first time period.

6. The blood analyzer according to claim 2, characterized in that: The first detection module includes a plurality of working positions and an optical detection mechanism, wherein the plurality of working positions are arranged along the circumference of the annular conveying mechanism, the working positions include the sample loading position and the detection position, and the optical detection mechanism is arranged corresponding to the detection position; Wherein, during the rotation of the annular conveying mechanism in each rotation cycle, a certain first reaction pool stops at the detection position, and the optical detection mechanism is used to collect the sample reaction state of the first reaction pool at the detection position.

7. The blood analyzer according to claim 6, characterized in that: The working position also includes a reagent adding position, and during the rotation of the annular conveying mechanism in each rotation cycle, a first reaction pool stops at the reagent adding position and is used to receive the detection reagent; Wherein, the detection reagent includes a first reagent and a second reagent with different components, and the first reaction pool on the reagent adding position is used to simultaneously receive the first reagent and the second reagent in each rotation cycle, or the first reaction pool on the reagent adding position is used to respectively receive the first reagent and the second reagent in different rotation cycles.

8. The blood analyzer according to claim 7, characterized in that: The first detection module includes a mixing mechanism, the working position also includes a mixing position, the mixing mechanism is arranged corresponding to the mixing position, during the rotation of the annular conveying mechanism in each rotation cycle, a first reaction pool stops at the mixing position, and the mixing mechanism is used to mix the detection reagent in the first reaction pool and the sample to be tested; and / or, The working position also includes a cleaning position. During the rotation of the annular conveying mechanism in each rotation cycle, a certain first reaction pool stops at the cleaning position. The first reaction pool at the cleaning position is used to receive a cleaning reagent.

9. The blood analyzer according to claim 8, characterized in that: The sample adding position, the cleaning position, the reagent adding position, the mixing position and the detection position are arranged on the annular conveying mechanism in a preset clockwise direction; Wherein, the annular conveying mechanism rotates 4 times and stops 3 times in each rotation cycle, and the annular conveying mechanism advances one position after each rotation cycle.

10. A blood analysis method, characterized in that: Applied to a blood analyzer, the blood analyzer includes a first detection module, a second detection module and a sampling module, the first detection module includes a ring-shaped transmission mechanism and a plurality of first reaction pools; the blood analysis method includes: Controlling the annular conveying mechanism to rotate one of the first reaction cells to a sample loading position; Controlling the sampling module to obtain a first sample to be tested, and adding the first sample to be tested to the first reaction pool of the sample adding position and the second detection module respectively; While controlling the first detection module and the second detection module to detect the first sample to be detected, the sampling module is controlled to add the second sample to be detected to the first reaction pool of the sample adding position.

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