Oral care composition comprising PAP and method of stabilizing same

Abstract

The present invention discloses an oral care composition comprising PAP and a method of stabilizing the composition, the oral care composition comprising PAP comprising: 1) PAP; 2) a polyol; (3) polyvinylpyrrolidone; 4) an orally acceptable carrier; wherein the polyhydric alcohol is one or a combination of more than one of sorbitol or mannitol; the polyvinylpyrrolidone at least comprises polyvinylpyrrolidone of which the weight-average molecular weight range is 40,000 to 55,000. According to the oral care composition, the polyhydric alcohol and the polyvinylpyrrolidone at least containing the weight-average molecular weight range of 40,000-55,000 are added, so that the stability of PAP in the composition can be improved; therefore, the oral care composition has a better whitening effect.

Description

Technical Field

[0001] The present invention relates to the technical field of oral care, and in particular to an oral care composition containing PAP and a method for stabilizing the PAP in the composition. Background Art

[0002] Teeth whitening is one of the demands of consumers when using oral care products. White teeth in the mouth can enhance personal image and temperament and increase personal confidence.

[0003] The stains on the tooth surface can be divided into exogenous stains and endogenous stains. Exogenous stains refer to foreign pigments that enter the oral cavity or pigments deposited on the tooth surface produced by bacteria in the oral cavity, which are generally removed by the mechanical action of the abrasive system in the toothpaste; endogenous stains refer to the staining of the internal structure of the teeth including enamel and dentin due to the influence of diseases or drugs, etc. In the prior art, bleaching agents such as peroxides are usually used as effective ingredients for whitening endogenous stains, among which hydrogen peroxide is the most commonly used. However, hydrogen peroxide releases oxygen free radicals when used, and oxygen free radicals further stimulate the oral soft tissues.

[0004] Phthalic imido peroxycaproic acid (PAP for short) is also one of the commonly used peroxides in recent years. Like hydrogen peroxide, PAP also has good teeth whitening effect. In addition, PAP does not release oxygen free radicals during the teeth whitening process and has no side effects on gums or oral mucosa. For example, Chinese patent application CN115768394A discloses a tooth whitening and / or tooth allergy patch or film, wherein the tooth whitening patch or film comprises phthalic imido peroxycaproic acid (PAP) and may comprise one or more water-soluble film-forming polymers and one or more plasticizers, wherein the preferred plasticizer may be glycerol.

[0005] However, PAP is easily decomposed and has low stability in oral care products, which limits the use of PAP. Therefore, it is necessary to develop a formula that can improve the stability of PAP. Summary of the invention

[0006] The first technical problem to be solved by the present invention is to provide an oral care composition containing PAP, which can improve the stability of PAP in the composition.

[0007] The second technical problem to be solved by the present invention is a method for improving the stability of PAP in an oral care composition containing PAP.

[0008] Definition of terms: In the present invention,

[0009] PVP-1 refers to polyvinylpyrrolidone with a weight average molecular weight of less than 40,000;

[0010] PVP-2 refers to polyvinylpyrrolidone with a weight average molecular weight range of 40,000-55,000;

[0011] PVP-3 refers to polyvinylpyrrolidone with a weight average molecular weight range of 55,000-900,000;

[0012] PVP-4 refers to polyvinylpyrrolidone with a weight average molecular weight range of 900,000-1,200,000;

[0013] PVP-5 refers to polyvinylpyrrolidone having a weight average molecular weight range of greater than 1,200,000.

[0014] In order to solve the above-mentioned first technical problem, the invention adopts the following technical solution :

[0015] An oral care composition comprising PAP, comprising:

[0016] 1) PAP;

[0017] 2) polyols;

[0018] 3) Polyvinylpyrrolidone;

[0019] 4) an orally acceptable carrier;

[0020] Wherein, the polyol is one or a combination of more than one of sorbitol or mannitol.

[0021] The polyvinyl pyrrolidone includes at least PVP-2.

[0022] As an embodiment, the polyol is a combination of sorbitol and mannitol.

[0023] As an embodiment, the mass percentage of the polyvinyl pyrrolidone in the oral care composition is in the range of 5-40%, preferably 10-35%.

[0024] As an embodiment, the mass proportion of the PVP-2 in the oral care composition is ≧5%.

[0025] As an embodiment, the polyvinyl pyrrolidone further includes one or a combination of more than one of PVP-3, PVP-4 or PVP-5.

[0026] As an embodiment, the polyvinyl pyrrolidone further comprises at least PVP-4.

[0027] As an embodiment, the weight proportion of the PAP in the oral care composition is 0.1-12%, preferably 0.3-12%, and more preferably 0.5-12%.

[0028] As an embodiment, the weight percentage of the polyol in the oral care composition is 5-50%, preferably 5-40%.

[0029] As an embodiment, the mass proportion of glycerin in the oral care composition is less than 2%.

[0030] As an embodiment, the oral care composition does not contain glycerin.

[0031] As an embodiment, the oral care composition further comprises hexametaphosphate.

[0032] As a preferred embodiment, the weight proportion of the hexametaphosphate in the oral care composition is 1-7%.

[0033] As an embodiment, the oral care composition further comprises tripolyphosphate.

[0034] As a preferred embodiment, the weight proportion of the tripolyphosphate in the oral care composition is 1-7%.

[0035] As one embodiment, the oral care composition is delivered in the form of a gel or a tooth patch.

[0036] As an embodiment, when delivered in the form of a dental strip, the oral care composition evaporates 30-60% of the solvent based on the weight of the composition itself.

[0037] To solve the above second technical problem, the invention adopts the following technical solution :

[0038] A method for improving the stability of PAP in an oral care composition comprising PAP, the method comprising the following steps:

[0039] A polyol and polyvinylpyrrolidone containing at least PVP-2 are added to an oral care composition containing PAP to stabilize the PAP in the composition.

[0040] As an embodiment, the mass proportion of the polyvinyl pyrrolidone in the oral care composition is in the range of 5-40%; the mass proportion of the PVP-2 in the oral care composition is in the range of ≧5%.

[0041] As an embodiment, the weight percentage of the polyol in the oral care composition is 5-50%, preferably 5-40%.

[0042] Any range described in the present invention includes the end value and any numerical value between the end values ​​and any sub-range formed by the end value or any numerical value between the end values.

[0043] Unless otherwise specified, all raw materials in the present invention can be purchased from the market, and the equipment used in the present invention can adopt conventional equipment in the relevant field or refer to the existing technology in the relevant field.

[0044] Compared with the prior art, the present invention has the following beneficial effects:

[0045] 1) The present invention provides an oral care composition comprising PAP, wherein the oral care composition further comprises a polyol, polyvinyl pyrrolidone and an orally acceptable carrier, wherein the polyvinyl pyrrolidone comprises at least PVP-2; adding a polyol and a polyvinyl pyrrolidone containing at least PVP-2 to the oral care composition can improve the stability of the PAP in the composition; and at the same time, the oral care composition has a better whitening effect.

[0046] 2) The present invention also provides a method for improving the stability of PAP in an oral care composition. DETAILED DESCRIPTION

[0047] In order to explain the present invention more clearly, the present invention is further described below in conjunction with preferred embodiments. It should be understood by those skilled in the art that the following specific description is illustrative rather than restrictive, and should not be used to limit the scope of protection of the present invention.

[0048] Unless otherwise specified, all percentages and ratios used herein are based on the weight of the total composition. Unless otherwise specified, the percentages, ratios and amounts of all ingredients mentioned herein are based on the actual amount of the ingredient, and do not include solvents, fillers or other substances that can be combined with these ingredients in commercial products.

[0049] The term "comprising" herein means that other steps and ingredients which do not affect the end result can be added.

[0050] The term "preferably" and its variants herein refer to embodiments of the present invention that can provide specific beneficial effects under specific circumstances. However, other embodiments may also be preferred under the same or other environments. In addition, the detailed description of one or more preferred embodiments does not mean that other embodiments are useless, and is not intended to exclude other embodiments in the scope of the present invention.

[0051] If no specific conditions are specified in the examples of the present invention, the experiments were carried out under conventional conditions or conditions recommended by the manufacturer; if no manufacturer is specified for the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0052] As one aspect of the present invention, an oral care composition comprising PAP of the present invention comprises:

[0053] 1) PAP;

[0054] 2) polyols;

[0055] 3) Polyvinylpyrrolidone;

[0056] 4) an orally acceptable carrier;

[0057] Wherein, the polyol is one or a combination of more than one of sorbitol or mannitol;

[0058] Wherein, the polyvinyl pyrrolidone includes at least PVP-2.

[0059] The present invention unexpectedly found that the oral care composition containing the above raw materials can improve the stability of PAP in the composition. In addition, in the process of selecting polyvinyl pyrrolidone, polyvinyl pyrrolidone containing at least PVP-2 can play the effect of stabilizing PAP.

[0060] Phthaloimidoperoxycaproic acid

[0061] Phthalimide peroxy caproic acid (PAP), as a kind of peroxide, has good bleaching effect at 5-85°C and has been used as an oxidant, bleaching agent, bactericidal disinfectant, etc. It has no long-term or chronic side effects, is harmless to the human body, and is biodegradable. Unlike hydrogen peroxide bleaching, the bleaching process of PAP does not release hydrogen peroxide or free radicals. The process involves the epoxidation of conjugated double bond molecules. However, like hydrogen peroxide, PAP has problems such as instability and low stability in oral care products. The molecular formula of phthalimide peroxy caproic acid is C 14 H 15 NO5 has the following structure:

[0062]

[0063] The present invention unexpectedly found that PAP has higher stability in an oral care composition containing polyols and polyvinylpyrrolidone (including at least PVP-2), and the oral care composition has better teeth whitening effect.

[0064] In certain embodiments of the present invention, the mass proportion of the PAP in the oral care composition is 0.1-12%. For example, but not limited to 0.3-12%, 0.5-12%, 0.8-12%, 1-12%, 1.5-12%, 2-12%, 3-12%, 4-12%, 5-12%, 6-12%, 8-12%, 10-12%, 0.1-10%, 0.3-10%, 0.5-10%, 0.8-10%, 1-10%, 1.5-10%, 2-10%, 4-10%, 5-10%, 6-10%, 8-10%, 0.1-8%, 0.3-8%, 0.5-8%, 0.8-8%, 1-8%, 15-8%, 2-8%, 3-8%, 4-8%, 5-8%, 6-8%, 0.1-6%, 0.3- 6%, 0.5-6%, 0.8-6%, 1-6%, 1.5-6%, 2-6%, 3-6%, 4-6%, 5-6%, 0.1-5%, 0.3-5%, 0.5-5%, 0.8-5%, 1-5%, 1.5-5%, 2-5%, 3-5%, 4-5%, 0.1-4%, 0.3-4%, 0.5-4%, 0.8-4%, 1-4%, 1.5-4%, 2-4%, 3-4%, 0.1-3%, 0.3-3%, 0.5-3%, 0.8-3%, 1-3%, 15-3%, 2-3%, 0.1-2%, 0.3-2%, 0.5-2%, 0.8-2%, 1-2%, 1.5-2%.

[0065] Polyvinylpyrrolidone

[0066] Polyvinyl pyrrolidone (PVP) is a non-ionic polymer compound and the most distinctive, most extensively studied fine chemical among N-vinylamide polymers. It is often used as an adhesive in oral care products.

[0067] In the present invention, PVP-1, PVP-2, PVP-3, PVP-4, and PVP-5 are all commercially available products, for example:

[0068] PVP-1 can be purchased from Ashland as PVPK15;

[0069] PVP-2 can be purchased from Ashland's PVP K30, BASF's K30 and 30;

[0070] PVP-3 can be purchased from Ashland's PVP K60 and BASF's K60;

[0071] PVP-4 can be purchased from Ashland's PVP K90, BASF's K90 and 90F;

[0072] PVP-5 can be purchased from Ashland as PVP K120.

[0073] The present invention unexpectedly found that, under the premise of containing polyols, the oral care composition further contains polyvinyl pyrrolidone (including at least PVP-2) can effectively improve the stability of PAP in the composition, and the oral care composition has a better effect of whitening teeth. That is to say, in the present application, polyvinyl pyrrolidone (including at least PVP-2) can not only play the role and function of a thickener, but also play the role of stabilizing PAP.

[0074] In certain embodiments of the present invention, the mass proportion of the polyvinyl pyrrolidone in the oral care composition is in the range of 5-40%. For example, but not limited to 5-35%, 5-30%, 5-25%, 5-20%, 5-15%, 5-10%, 10-35%, 10-30%, 10-25%, 10-20%, 10-15%, 15-35%, 15-30%, 15-25%, 15-20%, 20-35%, 20-30%, 20-25%, 25-35%, 25-30%.

[0075] In certain embodiments of the present invention, the mass percentage of the PVP-2 in the oral care composition is ≧5%.

[0076] In certain embodiments of the present invention, the polyvinyl pyrrolidone further comprises one or a combination of more than one of PVP-3, PVP-4 or PVP-5.

[0077] In the prior art, PVP is also a type of thickener. In addition to PVP, other thickeners may be added to the formula, such as carboxymethyl cellulose in the embodiment.

[0078] Polyols

[0079] In certain embodiments of the present invention, the polyol is sorbitol or mannitol, or a combination of more than one thereof.

[0080] The sorbitol and mannitol are both 1,2,3,4,5,6-hexanehexaol, wherein mannitol is an isomer of sorbitol, and both are sweeteners or moisturizers widely used in oral care products.

[0081] The present invention unexpectedly discovered that when one or more of sorbitol or mannitol is added to an oral care product and polyvinyl pyrrolidone (including at least PVP-2) is simultaneously added to the oral care composition, the PAP in the oral care composition has a higher stability, enabling the oral care composition to have a better teeth whitening effect.

[0082] In certain embodiments of the present invention, the mass proportion of the polyol in the oral care composition is 5-50%. For example, but not limited to, 5-45%, 5-40%, 5-35%, 5-30%, 5-25%, 5-20%, 5-15%, 5-10%, 10-50%, 10-45%, 10-40%, 10-35%, 10-30%, 10-25%, 10-20%, 10-15%, 15-50%, 15-45%, 15-40%, 15-35%, 15-30%, 15-25%, 15-2 0%, 20-50%, 20-45%, 20-40%, 20-35%, 20-30%, 20-25%, 25-50%, 25-45%, 25-40%, 25-35%, 25-30%, 30-50%, 30-45%, 30-40%, 30-35%, 35-50%, 35-45%, 35-40%, 35-45%, 40-50%, 40-45%, 45-50%.

[0083] Hexametaphosphate

[0084] Hexametaphosphates can be used as pH adjusters, tooth whitening agents, or anticalculus agents in oral care compositions.

[0085] In certain embodiments of the present invention, the hexametaphosphate is a potassium salt, a sodium salt or an ammonium salt of hexametaphosphate.

[0086] In certain embodiments of the present invention, the mass proportion of the hexametaphosphate in the oral care composition is 1-7%. For example, but not limited to 1-6%, 1-5%, 1-4.5%, 1-4%, 1-3.5%, 1-3%, 1-2.5%, 1.5-2%, 1-1.5%, 1.5-7%, 1.5-6%, 1.5-5%, 1.5-4.5%, 1.5-4%, 1.5-3.5%, 1.5-3%, 1.5-2.5%, 1.5-2%, 2-7%, 2-6%, 2-5%, 2-4.5%, 2-4%, 2-3.5%, 2-3%, 2-2.5%, 2-6%, 2-5%, 2-4 .5%, 2-4%, 2-3.5%, 2-3%, 2-2.5%, 2.5-7%, 2.5-6%, 2.5-5%, 2.5-4.5%, 2.5-4%, 2.5-3.5%, 2.5-3%, 3-7%, 3-6%, 3-5%, 3-4.5%, 3-4%, 3-3.5%, 3.5-7%, 3.5-6%, 3.5-5%, 3.5-4.5%, 3.5-4%, 4-7%, 4-6%, 4-5%, 4-4.5%, 5-7%, 5-6%, 6-7%. In the present invention, by adding appropriate hexametaphosphate to the oral care composition, the PAP in the oral care composition of the present application can have higher stability and can make the oral care composition have better teeth whitening effect.

[0087] Tripolyphosphate

[0088] Tripolyphosphates are useful as pH adjusters, tooth whitening agents, or anticalculus agents in oral care compositions.

[0089] In certain embodiments of the present invention, the tripolyphosphate is a potassium salt, a sodium salt or an ammonium salt of tripolyphosphate.

[0090] In certain embodiments of the present invention, the mass proportion of the tripolyphosphate in the oral care composition is 1-7%. For example, but not limited to 1-6%, 1-5%, 1-4.5%, 1-4%, 1-3.5%, 1-3%, 1-2.5%, 1.5-2%, 1-1.5%, 1.5-7%, 1.5-6%, 1.5-5%, 1.5-4.5%, 1.5-4%, 1.5-3.5%, 1.5-3%, 1.5-2.5%, 1.5-2%, 2-7%, 2-6%, 2-5%, 2-4.5%, 2-4%, 2-3.5%, 2-3%, 2-2.5%, 2-6%, 2-5%, 2-4 .5%, 2-4%, 2-3.5%, 2-3%, 2-2.5%, 2.5-7%, 2.5-6%, 2.5-5%, 2.5-4.5%, 2.5-4%, 2.5-3.5%, 2.5-3%, 3-7%, 3-6%, 3-5%, 3-4.5%, 3-4%, 3-3.5%, 3.5-7%, 3.5-6%, 3.5-5%, 3.5-4.5%, 3.5-4%, 4-7%, 4-6%, 4-5%, 4-4.5%, 5-7%, 5-6%, 6-7%. In the present invention, on the basis of adding hexametaphosphate, tripolyphosphate is further added to the oral care composition, so that the oral care composition can have a better effect of whitening teeth.

[0091] Other orally acceptable carriers

[0092] In the present invention, the "orally acceptable carrier" refers to any vehicle suitable for formulating the oral care composition disclosed in the present invention; when the orally acceptable carrier is retained in the mouth in the amount disclosed in the present invention without being swallowed for a period of time sufficient to allow effective contact with the tooth surface as required by the present invention, it is harmless to mammals; in general, the orally acceptable carrier will not be harmful even if it is swallowed unintentionally; suitable orally acceptable carriers include, for example, one or more of the following substances: water, volatile solvents, abrasives, surfactants, thickeners, pH adjusters, humectants, flavoring agents, visual aids (for example, pigments, dyes or mixtures thereof), anti-caries agents, antibacterial agents, whitening agents, desensitizing agents, preservatives, and mixtures thereof, etc.

[0093] In certain embodiments of the present invention, the oral care composition is delivered in the form of a gel or a tooth patch.

[0094] In certain embodiments of the present invention, the oral care composition is delivered in the form of a tooth patch, wherein the composition evaporates 30-60% of the solvent based on the weight of the composition itself.

[0095] As another aspect of the present invention, the present invention provides a method for improving the stability of PAP in an oral care composition containing PAP, the steps of the method are as follows:

[0096] A polyol and polyvinylpyrrolidone containing at least PVP-2 are added to an oral care composition containing PAP to stabilize the PAP in the composition.

[0097] In certain embodiments of the present invention, the weight percentage of the polyol in the oral care composition is 5-50%, preferably 5-40%.

[0098] In certain embodiments of the present invention, the mass percentage of the polyvinyl pyrrolidone in the oral care composition is in the range of 5-40%; the mass percentage of the PVP-2 in the oral care composition is in the range of ≧5%.

[0099] Testing method for whitening effect of the composition of the present invention

[0100] 1) The experiment selected bovine incisors with smooth surfaces and no caries, and made 8mm×8mm enamel blocks. 25 blocks were randomly divided into 5 groups, and freshly dyed bovine enamel blocks were obtained using the same dyeing scheme. Before the experiment, the Lab value of the dyed bovine teeth was tested with a colorimeter;

[0101] 2) Take 0.5g of sample or a 1cm*1cm tooth paste, and apply or stick it on the surface of the bovine enamel block obtained in step 1) of the same area. Then place the bovine enamel blocks in beakers filled with equal amounts of artificial saliva, place the beakers on a shaker, and shake them continuously. Calculate the residence time of the gel or tooth paste product on the surface of the bovine enamel block, and measure the Lab value of the bovine enamel block again with a colorimeter after 6 hours, and calculate the difference in Lab values ​​before and after.

[0102] 3) According to the standards set by the International Committee of Illumination (CIE), the Hunter Lab value is measured. The Lab system provides a numerical representation of the three-dimensional color space, where L* represents the brightness axis, a* represents the red-green axis, and b* represents the yellow-blue axis. Usually the L* axis and b* axis are most suitable for measuring tooth whiteness. The larger the L* value, the smaller the b* value, and the whiter the teeth. The difference between the L* value before and after is expressed as △L*(L 使用凝胶后 -L 使用凝胶前 ) to indicate. Specific embodiments

[0104] Comparative Examples 1-4, Examples 1-4

[0105] Comparative Examples 1-4 and Examples 1-4 oral care compositions were prepared according to the formula in Table 1, and all data in the table are in weight percentage.

[0106] Table 1:

[0107]

[0108] From Table 1 we can see that:

[0109] Comparative Example 1 uses 30% of glycerin as a moisturizer;

[0110] Comparative Example 2 uses 30% polyethylene glycol as a moisturizer;

[0111] Comparative Example 3 uses 30% of propylene glycol as a moisturizer;

[0112] Comparative Example 4 uses sorbitol and glycerin as moisturizers, wherein the added amount of sorbitol is 25% and the added amount of glycerin is 5%;

[0113] Example 1: 30% of sorbitol is added as a moisturizer;

[0114] Example 2 uses sorbitol and polyethylene glycol as moisturizers, wherein the added amount of sorbitol is 25% and the added amount of polyethylene glycol is 5%;

[0115] Example 3 uses sorbitol and propylene glycol as moisturizers, wherein the added amount of sorbitol is 25% and the added amount of propylene glycol is 5%;

[0116] Example 4 uses sorbitol and glycerol as moisturizers, wherein the added amount of sorbitol is 28% and the added amount of glycerol is 2%;

[0117] After the preparation of the comparative examples 1-4 and the embodiments 1-4 was completed, they were placed at room temperature for 1 week, the concentration of PAP in the formula was detected, and the recovery rate of PAP was calculated. The results are shown in Table 2.

[0118] Table 2:

[0119]

[0120]

[0121] From Table 2 we can see that:

[0122] The PAP in the formulas of Examples 1-4 has a higher recovery rate, while the PAP in the formulas of Comparative Examples 1-4 has a relatively obvious degradation. That is, the recovery rate of Comparative Example 1 using glycerol as a humectant is only 73.08%, the recovery rate of Comparative Example 2 using polyethylene glycol as a humectant is only 57.69%, the recovery rate of Comparative Example 3 using propylene glycol as a humectant is only 54.62%, and the recovery rate of PAP in Comparative Example 4 using sorbitol and glycerol as humectants, wherein the added amount of sorbitol is 25% and the added amount of glycerol is 5%, is only 73.85%, which is equivalent to Comparative Example 1;

[0123] When the formula is made of Example 1 with sorbitol as the moisturizer, the PAP recovery rate is increased to 98.46%, and when the formula is made of Example 2 with sorbitol and polyethylene glycol as the moisturizer, the PAP recovery rate is also maintained at 94.62%, and when the formula is made of Example 3 with sorbitol and propylene glycol as the moisturizer, the PAP recovery rate is 92.31%, and when the formula is made of Example 4 with sorbitol and glycerol as the moisturizer and the addition amount of glycerol is only 2%, the PAP recovery rate is 83.08%. It can be seen that when glycerol, polyethylene glycol or propylene glycol are used as the moisturizer alone, PAP is degraded to a large extent, while when sorbitol is used as the moisturizer, the PAP in the formula can be stabilized, and when sorbitol is matched with polyethylene glycol, propylene glycol and low concentration (no more than 5%) of glycerol, the PAP in the formula is also basically stable.

[0124] Comparative Examples 5-12, Examples 5-7

[0125] Comparative Examples 5-12 and Examples 5-7 were prepared according to the formulation in Table 3. The data in the table are all weight percentages. For ease of comparison, Example 1 is included in Table 3.

[0126] Table 3:

[0127]

[0128] Table 3 (continued):

[0129]

[0130]

[0131] As can be seen from Table 3, Comparative Examples 5-12 and Examples 1 and 5-7 selected PVP with different weight average molecular weights as adhesives, wherein:

[0132] Comparative Example 5 uses PVP-1 as a binder;

[0133] Comparative Example 6 uses PVP-1 and PVP-2 as adhesives;

[0134] Comparative Example 7 uses PVP-3 as a binder;

[0135] Comparative Example 8 uses PVP-4 as a binder;

[0136] Comparative Example 9 uses PVP-5 as a binder;

[0137] Comparative Example 10 uses PVP-1 and PVP-5 as adhesives;

[0138] Comparative Example 11 uses PVP-1 and PVP-4 as adhesives;

[0139] Comparative Example 12 uses PVP-4 and PVP-5 as adhesives;

[0140] Example 5 uses PVP-2 as a binder;

[0141] Example 6 uses PVP-2 and PVP-3 as adhesives;

[0142] Example 1 uses PVP-2 and PVP-4 as adhesives;

[0143] Example 7 uses PVP-2 and PVP-5 as adhesives;

[0144] After the preparation of the comparative examples 5-12 and the embodiments 5-7 was completed, they were placed at room temperature for 1 week, the concentration of PAP in the formula was detected, and the recovery rate of PAP was calculated. The results are shown in Table 4.

[0145] Table 4:

[0146]

[0147] Table 4 (continued):

[0148] Example 5 Example 6 Example 1 Example 7 PAP concentration 1.13 1.08 1.28 1.16 PAP recovery rate 86.92％ 83.08％ 98.46％ 89.23％

[0149] It can be seen from Table 4 that the PAP recovery rates in the formulations of Comparative Examples 5-12 are all at a relatively low level, while the PAP recovery rates of Examples 1 and 5-7 are significantly increased compared with Comparative Examples 5-7, especially Example 1, which has the most obvious increase.

[0150] That is, in the same formula skeleton, when PVP-2 is used as the adhesive or PVP-2 and PVP-3, PVP-4 or PVP-5 are matched to form an adhesive, the PAP in the formula has better stability, especially when PVP-2 and PVP-4 are used as adhesives, the PAP stability is the best.

[0151] Combining Table 2 and Table 4, it can be seen that in the gel formula containing PAP, only when sorbitol is mainly used as the humectant and PVP-2 or PVP-2 and PVP-3, PVP-4 or PVP-5 are selected to form an adhesive, the recovery rate of PAP will increase significantly, especially when PVP-2 and PVP-4 are matched to form an adhesive, the increase in the recovery rate of PAP is most obvious.

[0152] Example 8, Comparative Example 13

[0153] Example 8 and Comparative Example 13 were prepared according to the formulation in Table 5. The data in the table are all weight percentages. For ease of comparison, Example 1 is included in Table 5.

[0154] Table 5:

[0155]

[0156] As can be seen from Table 5, Example 8 adds sodium hexametaphosphate (SHMP) on the basis of Example 1, and Comparative Example 13 adds tetrasodium pyrophosphate (TSPP) on the basis of Example 1.

[0157] After the above examples and comparative examples were prepared, they were placed at 40°C for 1 week, the concentration of PAP in the formula was detected, and the recovery rate of PAP was calculated. The results are shown in Table 6.

[0158] Table 6:

[0159] Example 1 Example 8 Comparative Example 13 PAP concentration 1.12 1.25 1.06 PAP recovery rate 86.15％ 96.15％ 81.54％

[0160] From Table 6 we can see that:

[0161] After being placed at 40°C for one week, PAP still has a good recovery rate, and in Example 8, in which sodium hexametaphosphate (SHMP) is added to Example 1, the recovery rate of PAP is further increased, while in Comparative Example 13, in which tetrasodium pyrophosphate (TSPP) is added to Example 1, the recovery rate of PAP does not increase, but decreases slightly. Although sodium hexametaphosphate and sodium pyrophosphate are both polyphosphates, not all polyphosphates can achieve the effect of improving the stability of PVP, and the invention also needs to be selected to achieve the beneficial effects of the invention.

[0162] Comparative Examples 14-15

[0163] Comparative Examples 14-15 were prepared according to the formulation in Table 7. The data in the table are all weight percentages. For ease of comparison, Comparative Example 1 is included in Table 7.

[0164] Table 7:

[0165]

[0166] From Table 7 we can see that:

[0167] Comparative Example 14 adds sodium hexametaphosphate (SHMP) to Comparative Example 1, and Comparative Example 15 adds tetrasodium pyrophosphate (TSPP) to Comparative Example 1.

[0168] After the above comparative example was prepared, it was placed at 40°C for 1 week, the concentration of PAP in the formula was detected, and the recovery rate of PAP was calculated. The results are shown in Table 8.

[0169] Table 8:

[0170] Comparative Example 1 Comparative Example 14 Comparative Example 15 PAP concentration 0.26 0.23 0.27 PAP recovery rate 20.00％ 17.69％ 20.77％

[0171] From Table 8 we can see that:

[0172] Comparative Example 1 was placed at 40°C for 1 week, and the PAP recovery rate was 20%; Comparative Example 14, in which sodium hexametaphosphate was added to Comparative Example 1, had a PAP recovery rate of 17.69%, which did not increase but decreased compared with Comparative Example 1; Comparative Example 15, in which tetrasodium pyrophosphate was added to Comparative Example 1, had a PAP recovery rate of 20.77%, which was the same as that of Comparative Example 1.

[0173] It can be seen from Table 6 and Table 8 that sodium hexametaphosphate can improve the stability of PAP and the recovery rate of PAP only in the formula mainly using sorbitol as the humectant.

[0174] Comparative Example 16

[0175] Comparative Example 16 was prepared according to the formula in Table 9. The data in the table are all weight percentages. For ease of comparison, Comparative Example 8 is included in Table 9.

[0176] Table 9:

[0177]

[0178] It can be seen from Table 9 that Comparative Example 16 is obtained by replacing the PAP in Example 8 with an equal amount of hydrogen peroxide.

[0179] After the above comparative example was prepared, it was placed at 40° C. for 1 week, the concentration of peroxide in the formula was detected, and the recovery rate of peroxide was calculated. The results are shown in Table 10.

[0180] Table 10:

[0181] Example 8 Comparative Example 16 Peroxide concentration 1.25 0.88 Peroxide recovery rate 96.15％ 67.69％

[0182] It can be seen from Table 10 that the recovery rate of hydrogen peroxide in Comparative Example 16 after being placed at 40° C. for 1 week is only 67.69%, which is lower than the recovery rate of PAP in the formula of Example 8; that is, in the formula of the present invention mainly using sorbitol as a humectant, sodium hexametaphosphate can better stabilize the PAP in the formula but cannot stabilize the hydrogen peroxide in the formula.

[0183] Examples 9-10

[0184] Examples 9-10 were prepared according to the formulation in Table 11. The data in the table are all weight percentages. For ease of comparison, Example 1 and Example 8 are included in Table 11.

[0185] Table 11:

[0186]

[0187] From Table 11 we can see that:

[0188] In Example 9, 2.5% of sodium tripolyphosphate (STPP) was added to the Example 1, and in Example 10, 2.5% of sodium hexametaphosphate and 2.5% of sodium tripolyphosphate were added to the Example 1.

[0189] After the above comparative examples were prepared, the changes in the L values ​​of Example 1 and Examples 8-10 were tested according to the test method for the whitening effect of the above composition. The results are shown in Table 12.

[0190] Table 12:

[0191] Example 1 Example 8 Example 9 Example 10 ΔL 6.68 9.91 9.52 15.07

[0192] It can be seen from Table 12 that the ΔL value of Example 1 is 6.68, the ΔL value of Example 8 is 9.91, which is 3.23 more than that of Example 1, the ΔL value of Example 9 is 9.52, which is 2.84 more than that of Example 1, and the ΔL value of Example 10 is 15.07, which is 8.39 more than that of Example 1, which is higher than the sum of 3.23 and 2.84. It can be seen that PAP, SHMP and STPP have the effect of synergistically increasing the whitening effect.

[0193] Examples 11-14, Comparative Examples 17-18

[0194] The gels of Examples 11-14 and Comparative Examples 17-18 were prepared according to the formulation in Table 13. The data in the table are all weight percentages. For ease of comparison, Example 1 is included in Table 13.

[0195] Table 13:

[0196]

[0197]

[0198] It can be seen from Table 13 that the only differences between Comparative Examples 17-18 and Examples 11-14 are the amount of sorbitol added and the water content, while the other ingredients and concentrations of the formula are the same, wherein:

[0199] Comparative Example 17 only added 3% sorbitol;

[0200] Example 11 added 5% sorbitol;

[0201] Example 12 adds 20% sorbitol;

[0202] Example 13 adds 40% sorbitol;

[0203] Example 14 adds 50% sorbitol;

[0204] Comparative Example 18 added 60% sorbitol.

[0205] After the above examples and comparative examples were prepared, they were placed at 40° C. for 1 week, the appearance of the formula was observed, the concentration of PAP in the formula was detected, and the recovery rate of PAP was calculated. The results are shown in Tables 14 and 15, respectively.

[0206] Table 14:

[0207] Comparative Example 17 Embodiment 11 Example 12 Example 1 Example 13 Comparative Example 18 Appearance Water Dividing Undivided water Undivided water Undivided water Undivided water Undivided water

[0208] It can be seen from Table 14 that among the comparative examples and embodiments above, only comparative example 17 separates water, that is, when the sorbitol content in the formula is higher than 5%, the appearance of the formula is stable and no water separation phenomenon is shown.

[0209] Table 15:

[0210] Comparative Example 17 Embodiment 11 Example 12 Example 13 Embodiment 14 Comparative Example 18 PAP concentration 1.28 1.26 1.27 1.24 1.17 1.01 PAP recovery rate 98.46％ 96.92％ 97.69％ 95.38％ 90.00％ 77.69％

[0211] It can be seen from Table 15 that the recovery rates of Comparative Example 17 and Examples 11-14 are still relatively high after being placed at 40°C for one week, but the recovery rate of Comparative Example 18 is significantly lower than that of Example 14, that is, when the concentration range of sorbitol in the formula is 3-50%, the PAP in the formula has good stability, especially when the concentration range of sorbitol is 3-40%, the recovery rate of PAP is more significant, and when the concentration of sorbitol in the formula is increased to 60%, the recovery rate of PAP is significantly reduced, that is, the stability of PAP is reduced.

[0212] It can be seen from Table 14 and Table 15 that when the sorbitol concentration in the formula is in the range of 5-50%, the appearance of the formula and the PAP in the formula can remain stable, especially when the sorbitol concentration in the formula is in the range of 10-40%, the effect is best.

[0213] Comparative Example 19, Examples 15-18

[0214] The gels of Comparative Example 19 and Examples 15-18 were prepared according to the formulation in Table 16. The data in the table are all weight percentages. For ease of comparison, Example 1 is included in Table 16.

[0215] Table 16:

[0216]

[0217] It can be seen from Table 16 that PAP with different mass percentages was added in Comparative Example 19, Example 1, and Examples 15-18, wherein:

[0218] Comparative Example 19 added 0.1% PAP;

[0219] Example 15 added 0.3% PAP;

[0220] Example 16 added 0.5% PAP;

[0221] Example 1 added 1.3% PAP;

[0222] Example 17 added 5% PAP;

[0223] Example 18 added 12% PAP;

[0224] After the above comparative example was prepared, it was placed at room temperature for 1 week, the concentration of PAP in the formula was detected, and the recovery rate of PAP was calculated. The results are shown in Table 17.

[0225] Table 17:

[0226] Comparative Example 19 Embodiment 15 Example 16 Example 1 Embodiment 17 Embodiment 18 PAP concentration 0.08 0.27 0.47 1.28 4.79 11.81 PAP recovery rate 80.00％ 90.00％ 94.00％ 98.46％ 95.80％ 98.42％

[0227] It can be seen from Table 17 that the PAP recovery rate of Comparative Example 19 is 80%, that is, when the PAP addition amount in the gel formula is only 0.1%, PAP still has a high recovery rate, and when the PAP addition amount in the gel formula is increased to 0.3% in Example 15, the PAP recovery rate is increased to 90%, and when the PAP addition amount in the gel formula is 0.5% in Example 16, the PAP recovery rate is further increased to 94%, and when the PAP addition amount is 12% in Example 18, the PAP recovery rate is 98.42%.

[0228] That is, when the amount of PAP added in the formula is 0.1-12%, PAP has a higher recovery rate, especially when the amount of PAP added in the formula is in the range of 0.3-12%, PAP has a higher recovery rate, and when the amount of PAP added in the formula is in the range of 0.5-12%, PAP has the best recovery rate. That is, when the amount of PAP added in the formula is only 0.1%, the recovery rate of PAP is only 80%; when the amount of PAP added in the formula reaches 0.3%, the recovery rate of PAP can reach 90%, and when the amount of PAP added in the formula is greater than or equal to 0.5%, the recovery rate of PAP is greater than or equal to 94%.

[0229] Examples 19-23, Comparative Examples 20-21

[0230] The gels of Examples 19-23 and Comparative Examples 20-21 were prepared according to the formulation in Table 18, and all data in the table are weight percentages.

[0231] Table 18:

[0232]

[0233] As can be seen from Table 18, Examples 19-23 and Comparative Examples 20-21 added PVP-2 in different mass proportions, wherein:

[0234] Comparative Example 20 added 3% PVP-2;

[0235] Example 19 added 5% PVP-2;

[0236] Example 20 added 10% PVP-2;

[0237] Example 21 added 20% PVP-2;

[0238] Example 22 added 30% PVP-2;

[0239] Example 23 added 40% PVP-2;

[0240] Comparative Example 21 added 3% PVP-2;

[0241] After the above comparative example was prepared, it was placed at room temperature for 1 week, the concentration of PAP in the formula was detected, and the recovery rate of PAP was calculated. The results are shown in Table 19.

[0242] Table 19:

[0243]

[0244]

[0245] From Table 19 we can see that:

[0246] When the addition amount of PVP-2 in the composition of Comparative Example 20 was 3%, the recovery rate of PAP was only 53.08%;

[0247] When the addition amount of PVP-2 in Example 19 was increased to 5% in the composition, the recovery rate of PAP was increased to 79.23%, which was significantly improved compared with Comparative Example 20;

[0248] When the addition amount of PVP-2 in Example 20 was increased to 10% in the composition, the recovery rate of PAP increased to 81.54%;

[0249] When the addition amount of PVP-2 in the composition of Example 21 was increased to 20%, the recovery rate of PAP increased to 88.46%;

[0250] When the addition amount of PVP-2 in the composition of Example 22 was increased to 30%, the recovery rate of PAP was 84.62%;

[0251] When the addition amount of PVP-2 in the composition of Example 23 was increased to 40%, the recovery rate of PAP was 82.31%;

[0252] When the addition amount of PVP-2 in the composition of Comparative Example 21 was increased to 45%, the recovery rate of PAP was only 63.08%, which was significantly lower than that of Example 23. That is, when the mass proportion of PVP-2 in the composition was in the range of 5-40%, PAP had a better recovery rate.

[0253] Examples 24-28, Comparative Examples 22-24

[0254] The gels of Examples 24-28 and Comparative Examples 22-24 were prepared according to the formulation in Table 20. The data in the table are all weight percentages. For ease of comparison, Example 1 is included in Table 20.

[0255] Table 20:

[0256]

[0257] Table 20 (continued):

[0258]

[0259]

[0260] As can be seen from Table 20, Examples 24-28 and Comparative Examples 22-24 added PVP-2 and PVP-4 in different mass proportions, wherein:

[0261] Example 24 added 5% PVP-2 and 5% PVP-4, that is, Example 24 added 10% polyvinyl pyrrolidone;

[0262] Example 25 added 10% PVP-2 and 5% PVP-4, that is, Example 25 added 15% polyvinyl pyrrolidone;

[0263] Example 26 added 20% PVP-2 and 10% PVP-4, that is, Example 26 added 30% polyvinyl pyrrolidone;

[0264] Example 27 added 20% PVP-2 and 15% PVP-4, that is, Example 27 added 35% polyvinyl pyrrolidone;

[0265] Example 28 added 20% PVP-2 and 20% PVP-4, that is, Example 28 added 40% polyvinyl pyrrolidone;

[0266] Comparative Example 22 added 20% PVP-2 and 25% PVP-4, that is, Comparative Example 22 added 45% polyvinyl pyrrolidone;

[0267] Comparative Example 23 added 25% PVP-2 and 20% PVP-4, that is, Comparative Example 23 added 45% polyvinyl pyrrolidone;

[0268] Comparative Example 24 added 30% PVP-2 and 15% PVP-4, that is, Comparative Example 24 added 45% polyvinyl pyrrolidone;

[0269] After the above comparative example was prepared, it was placed at room temperature for 1 week, the concentration of PAP in the formula was detected, and the recovery rate of PAP was calculated. The results are shown in Table 21.

[0270] Table 21:

[0271] Embodiment 24 Example 1 Embodiment 25 Embodiment 26 Embodiment 27 Embodiment 28 PAP concentration 1.19 1.28 1.21 1.23 1.17 1.09 PAP recovery rate 91.54％ 98.46％ 93.08％ 94.62％ 90.00％ 83.85％

[0272] Table 21 (continued):

[0273]

[0274]

[0275] From Table 21 we can see that:

[0276] When the amount of polyvinyl pyrrolidone added to the composition in Example 24 was 10%, the recovery rate of PAP was 91.54%;

[0277] When the amount of polyvinyl pyrrolidone added to the composition in Example 1 was 15%, the recovery rate of PAP was 98.46%;

[0278] When the amount of polyvinyl pyrrolidone added to the composition of Example 25 and Example 26 was 30%, the recovery rates of PAP were 93.08% and 94.62%, respectively;

[0279] When the amount of polyvinyl pyrrolidone added to the composition in Example 27 was 35%, the recovery rate of PAP was 90.00%;

[0280] When the amount of polyvinyl pyrrolidone added to the composition in Example 28 was 40%, the recovery rate of PAP was 93.85%;

[0281] When the amount of polyvinyl pyrrolidone added to the composition of Comparative Examples 22-24 was increased to 45%, the recoveries of PAP were 70.00%, 67.69% and 65.38%, respectively, which were significantly lower than those of Example 1 and Examples 24-28. That is, when the mass proportion of polyvinyl pyrrolidone in the composition was 5-40%, PAP had a better recovery rate, especially when the mass proportion of polyvinyl pyrrolidone in the composition was 10-35%, the recovery rate of PAP was better.

[0282] Examples 29-34

[0283] The gels of Examples 29-34 were prepared according to the formulation in Table 22. The data in the table are all weight percentages. For ease of comparison, Examples 11-14 are included in Table 22.

[0284] Table 22:

[0285]

[0286] Table 22 (continued):

[0287]

[0288] As can be seen from Table 22, Examples 29-32 added mannitol at different weight percentages, Examples 33-34 simultaneously added mannitol and sorbitol at different weight percentages and Comparative Examples 22-24, wherein:

[0289] Example 29 added 5% mannitol;

[0290] Example 39 adds 20% mannitol;

[0291] Example 31 added 40% mannitol;

[0292] Example 32 added 50% mannitol;

[0293] Example 33 added 20% sorbitol and 20% mannitol;

[0294] Example 34 added 25% sorbitol and 15% mannitol;

[0295] After the above comparative example was prepared, it was placed at room temperature for 2 weeks, the concentration of PAP in the formula was detected, and the recovery rate of PAP was calculated. The results are shown in Table 23.

[0296] Table 23:

[0297] Embodiment 11 Example 12 Example 13 Embodiment 14 Embodiment 29 Embodiment 30 PAP concentration 1.22 1.23 1.18 1.1 1.19 1.24 PAP recovery rate 93.85％ 94.62％ 90.77％ 84.62％ 91.54％ 95.38％

[0298] Table 23 (continued):

[0299] Embodiment 31 Embodiment 32 Embodiment 33 Embodiment 34 PAP concentration 1.22 1.15 1.27 1.28 PAP recovery rate 93.85％ 88.46％ 97.69％ 98.46％

[0300] From Table 23 we can see that:

[0301] When only mannitol was added to the composition of Example 29, and the added amount was 5%, the recovery rate of PAP was 91.54%;

[0302] When only mannitol was added to the composition of Example 30, and the added amount was 20%, the recovery rate of PAP was 95.38%;

[0303] When only mannitol was added to the composition of Example 31, and the added amount was 40%, the recovery rate of PAP was 93.85%;

[0304] When only mannitol was added to the composition of Example 32, and the added amount was 50%, the recovery rate of PAP was 88.46%;

[0305] When sorbitol and mannitol were added to the composition of Example 33 at the same time, and the added amount of sorbitol was 20%, the added amount of mannitol was 20%, that is, the total added amount of sorbitol and mannitol was 40%, the recovery rate of PAP was 97.69%;

[0306] When sorbitol and mannitol were added to the composition of Example 34 at the same time, and the added amount of sorbitol was 25%, and the added amount of mannitol was 15%, that is, the total added amount of sorbitol and mannitol was 40%, the recovery rate of PAP was 98.46%;

[0307] In summary, both mannitol and sorbitol can improve the stability of PAP in the composition formula, especially when sorbitol and mannitol are added to the composition at the same time, the stability of PAP can be further improved.

[0308] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, materials, or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the embodiment of this specification. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example.

[0309] In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradiction. The above description is only an embodiment of the embodiment of this specification and is not intended to limit the embodiment of this specification. For those skilled in the art, the embodiment of this specification may have various changes and variations. Any modification, equivalent substitution, improvement, etc. made within the spirit and principle of the embodiment of this specification shall be included in the scope of the claims of the embodiment of this specification.

Claims

1. An oral care composition comprising PAP, comprising: 1) PAP; 2) polyols; 3) Polyvinylpyrrolidone; 4) an orally acceptable carrier; in, The polyol is one or a combination of more than one of sorbitol or mannitol; The polyvinyl pyrrolidone at least includes polyvinyl pyrrolidone having a weight average molecular weight ranging from 40,000 to 55,000.

2. The oral care composition according to claim 1, characterized in that: The polyol is a combination of sorbitol and mannitol.

3. The oral care composition according to claim 1, characterized in that: The mass percentage of the polyvinyl pyrrolidone in the oral care composition is in the range of 5-40%.

4. The oral care composition according to claim 3, characterized in that: The weight average molecular weight of the polyvinyl pyrrolidone in the range of 40,000-55,000 accounts for ≧5% of the oral care composition.

5. The oral care composition according to claim 1, characterized in that: The polyvinyl pyrrolidone also includes one or a combination of polyvinyl pyrrolidone with a weight average molecular weight range of 55,000-900,000, polyvinyl pyrrolidone with a weight average molecular weight range of 900,000-1200,000, or polyvinyl pyrrolidone with a weight average molecular weight greater than 1200,000.

6. The oral care composition according to claim 5, characterized in that: The polyvinyl pyrrolidone at least includes polyvinyl pyrrolidone with a weight average molecular weight ranging from 900,000 to 1200,000.

7. The oral care composition according to claim 1, characterized in that: The weight proportion of the PAP in the oral care composition is 0.1-12%, preferably 0.3-12%, and more preferably 0.5-12%.

8. The oral care composition according to claim 1, characterized in that: The weight percentage of the polyol in the oral care composition is 5-50%, preferably 5-40%.

9. The oral care composition according to claim 1, characterized in that: The mass proportion of glycerol in the oral care composition is less than 2%.

10. The oral care composition according to claim 9, characterized in that: The oral care composition does not include glycerin.

11. The oral care composition according to claim 1, characterized in that: The oral care composition further comprises hexametaphosphate.

12. The oral care composition according to claim 11, characterized in that: The weight proportion of the hexametaphosphate in the oral care composition is 1-7%.

13. The oral care composition according to claim 11, characterized in that: The oral care composition further comprises tripolyphosphate.

14. The oral care composition according to claim 13, characterized in that: The tripolyphosphate accounts for 1-7% by weight in the oral care composition.

15. The oral care composition according to claim 1, characterized in that: The oral care composition is delivered in the form of a gel or a tooth patch.

16. The oral care composition according to claim 15, characterized in that: When delivered in the form of a dental strip, the oral care composition evaporates 30-60% of the solvent based on the weight of the composition.

17. A method for improving the stability of PAP in an oral care composition comprising PAP, characterized in that: The steps of this method are as follows: A polyol and at least polyvinyl pyrrolidone having a weight average molecular weight of 40,000-55,000 are added to an oral care composition containing PAP to stabilize the PAP in the composition.

18. The method according to claim 17, characterized in that: The mass proportion of the polyvinyl pyrrolidone in the oral care composition is in the range of 5-40%; the mass proportion of the polyvinyl pyrrolidone with a weight average molecular weight of 40,000-55,000 in the oral care composition is in the range of ≧5%.

19. The method according to claim 17, characterized in that: The weight percentage of the polyol in the oral care composition is 5-50%, preferably 5-40%.

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