A matte salt cation adsorbent, its preparation method and application

By preparing sulfonium salt cationic adsorbents and utilizing the ring-opening polymerization and cross-linking reaction of methionine monomers, the selectivity and safety issues of blood purification in MRSA bloodstream infections were solved. This achieved efficient adsorption and rapid removal of bacteria, avoided the risk of coagulation, and possessed bactericidal effects.

CN119912684BActive Publication Date: 2026-07-03CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES
Filing Date
2025-01-21
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Existing technologies lack highly selective and safe blood purification methods for treating MRSA bloodstream infections. Conventional antibiotics are highly toxic and bacterial resistance is increasing, while non-pharmacological blood purification methods have limited effectiveness in pathogen clearance.

Method used

A sulfonium salt cationic adsorbent was prepared by ring-opening polymerization of methionine monomers to form a methionine polymer, which was then cross-linked with halogen-containing compounds or functional group compounds to form a sulfonium salt structure with bacterial selectivity, which was used to rapidly adsorb and kill bacteria in the blood.

Benefits of technology

It achieves efficient adsorption and rapid removal of bacteria in the blood, has excellent blood compatibility, does not cause coagulation or hemolysis risks, and also has bactericidal properties, which can block the generation of cytokine storms.

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Abstract

This invention provides a sulfonium salt cationic adsorbent, its preparation method, and its application. The preparation method of the sulfonium salt cationic adsorbent involves first performing a ring-opening polymerization reaction on methionine monomers to form a methionine polymer; then, using this bacterially selective methionine polymer as a base, a bacterial adsorbent is further prepared. One route involves cross-linking the aforementioned methionine polymer base with a halogen-containing compound to form a cross-linked sulfonium salt structure. Another route involves first modifying the aforementioned methionine polymer base with a compound containing functional groups, introducing reactive functional groups into its side chains, and then cross-linking the modified methionine polymer with a cross-linkable compound to form a cross-linked sulfonium salt structure; or mixing the modified methionine polymer with a loadable matrix to coat the surface of the matrix with a layer of sulfonium salt polymer. The above adsorbents can effectively adsorb bacteria without causing thrombosis or coagulation.
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