Toothpaste with anti-allergy effect and preparation method thereof

Abstract

The invention relates to toothpaste with an anti-allergy effect and a preparation method thereof, the toothpaste is prepared from an anti-allergy composition, a thickening agent, a friction agent, a foaming agent and water, and the anti-allergy composition is prepared from a calendula extract, a chamomile extract, a propolis extract, a tea leaf extract, a pepper extract and a mint extract. The toothpaste prepared by the invention has a good anti-allergy effect and a good plugging effect on dental tubules, and can also refresh breath, and the calendula extract, the chamomile extract, the propolis extract, the tea leaf extract, the pepper extract and the mint extract have a certain synergistic effect on the effects.

Description

Technical Field

[0001] The invention belongs to the technical field of daily necessities and relates to a toothpaste with anti-allergic effect and a preparation method thereof. Background Art

[0002] In modern society, oral health issues are increasingly receiving widespread attention. Tooth sensitivity, as a common oral problem, seriously affects the quality of life of many people. Tooth sensitivity usually manifests as short and sharp pain when the teeth are stimulated by cold, heat, sourness, sweetness, etc. This pain not only causes trouble when eating, but may also cause patients to fear certain foods, thereby affecting normal dietary intake and nutritional balance.

[0003] According to relevant research statistics, about 30%-40% of the world's population suffers from varying degrees of tooth sensitivity. In daily life, improper brushing, gum recession, enamel wear, periodontal disease and other factors may lead to tooth sensitivity. For example, excessive brushing, using a hard-bristled toothbrush and brushing too hard may damage the enamel and expose the dentin, thus causing tooth sensitivity.

[0004] There are many types of toothpastes on the market, but products for tooth sensitivity still have many shortcomings in terms of efficacy and safety. Although some traditional anti-sensitivity toothpastes contain common anti-sensitivity ingredients such as potassium nitrate, they often have problems such as slow onset and short duration of action. Many users need to use this type of toothpaste for a long time before they can feel a certain effect, and once they stop using it, the symptoms of tooth sensitivity are likely to reappear.

[0005] In addition, some anti-allergic toothpastes add some chemical ingredients that are irritating to the oral mucosa in order to achieve a quick anti-allergic effect. Long-term use may cause potential harm to oral health. For example, some ingredients may disrupt the balance of microorganisms in the mouth, increase the risk of oral infection, or cause discomfort such as dryness and itching of the oral mucosa.

[0006] As people pay more and more attention to oral health, the demand for toothpaste with efficient and safe anti-sensitivity effect is becoming more urgent. Developing an anti-sensitivity toothpaste that can quickly relieve tooth sensitivity symptoms and is non-irritating has become an urgent problem to be solved in the oral care field. Summary of the invention

[0007] In view of the deficiencies of the prior art, the object of the present invention is to provide a toothpaste with anti-sensitivity effect and a preparation method thereof.

[0008] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0009] In a first aspect, the present invention provides a toothpaste with anti-sensitivity effect. The raw materials for preparing the toothpaste include an anti-sensitivity composition, a thickener, an abrasive, a foaming agent and water. The anti-sensitivity composition includes calendula extract, chamomile extract, propolis extract, tea extract, prickly ash extract and mint extract.

[0010] The toothpaste prepared by the present invention has a relatively good anti-sensitivity effect. The method for treating dentin sensitivity can be to apply a blocking material on the dentin surface to seal the exposed dentin tubules. The toothpaste prepared by the present invention has a relatively good blocking effect on the dental tubules, and the calendula extract, chamomile extract, propolis extract, tea extract, prickly ash extract and mint extract have a certain synergistic effect on the above effect. At the same time, the toothpaste prepared by the present invention also has the effect of refreshing breath.

[0011] Preferably, the raw materials for preparing the toothpaste include, by weight, 0.5-2 parts of anti-sensitivity composition, 0.5-1.2 parts of thickener, 17-23 parts of abrasive, 4-8 parts of foaming agent and 28-35 parts of water.

[0012] The mass fraction of the anti-allergic composition can be selected from 0.5 parts, 0.8 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, etc., the mass fraction of the thickener can be selected from 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, 1.1 parts, 1.2 parts, etc., the mass fraction of the friction agent can be selected from 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, etc., the mass fraction of the foaming agent can be selected from 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, etc., the mass fraction of water can be selected from 28 parts, 29 parts, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, etc., and other specific point values ​​within the above numerical range can be selected, which will not be repeated here one by one.

[0013] Preferably, the anti-allergic composition comprises, by mass, 1-2 parts of calendula extract, 1-3 parts of chamomile extract, 0.5-2 parts of propolis extract, 1-2 parts of tea extract, 0.1-1 parts of Zanthoxylum bungeanum extract, and 1-3 parts of peppermint extract.

[0014] The mass proportion of calendula extract can be selected as 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2 parts, etc.; the mass proportion of chamomile extract can be selected as 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.4 parts, 2.6 parts, 2.8 parts, 3 parts, etc.; the mass proportion of propolis extract can be selected as 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, etc.; the mass proportion of tea extract can be selected as The mass fractions of the peppermint extract can be selected from 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2 parts, etc. The mass fractions of the peppermint extract can be selected from 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, etc. The mass fractions of the peppermint extract can be selected from 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.4 parts, 2.6 parts, 2.8 parts, 3 parts, etc. Other specific point values ​​within the above numerical range can be selected, which will not be repeated here one by one.

[0015] Preferably, the foaming agent includes any one or a combination of at least two of sodium lauroyl sarcosinate, lauryl glucoside, sodium cocoamidopropionate or C8-C14 alkyl glucoside.

[0016] Preferably, the abrasive agent includes any one of hydrated silica, zeolite or pumice, or a combination of at least two of them.

[0017] Preferably, the thickener comprises hydroxypropyl methylcellulose and / or xanthan gum.

[0018] Preferably, the raw materials for preparing the toothpaste further include any one or a combination of at least two of a moisturizer, a sweetener, a fragrance, an anti-caries agent, a pH adjuster, a preservative, and a cooling agent.

[0019] Preferably, the raw materials for preparing the toothpaste further include, by weight, any one or a combination of at least two of 35-45 parts of moisturizer, 1-1.5 parts of sweetener, 0.7-1.5 parts of fragrance, 0.1-0.5 parts of anti-caries agent, 0.1-0.5 parts of pH adjuster, 0.1-0.5 parts of preservative, and 0.05-0.2 parts of cooling agent.

[0020] The mass proportion of moisturizer can be 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, etc. The mass proportion of sweetener can be 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, etc. The mass proportion of fragrance can be 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, etc. The mass proportion of mothproofing agent can be 0.1 parts, 0.2 parts , 0.3 parts, 0.4 parts, 0.5 parts, etc., the mass parts of pH adjusters can be selected as 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, etc., the mass parts of preservatives can be selected as 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, etc., the mass parts of cooling agents can be selected as 0.05 parts, 0.08 parts, 0.1 parts, 0.12 parts, 0.15 parts, 0.18 parts, 0.2 parts, etc., and other specific point values ​​within the above numerical range can be selected, so they will not be described one by one here.

[0021] Preferably, the humectant comprises sorbitol and / or polyethylene glycol-8.

[0022] Preferably, the sweetener comprises xylitol and / or galactosamine.

[0023] Preferably, the fragrance comprises essence.

[0024] Preferably, the moth repellent comprises sodium fluoride.

[0025] Preferably, the pH adjuster comprises sodium hydroxide.

[0026] Preferably, the preservative comprises sodium benzoate.

[0027] Preferably, the cooling agent comprises menthone glycerol ketal.

[0028] In a second aspect, the present invention provides a method for preparing a toothpaste with anti-sensitivity effect according to the first aspect, the preparation method comprising: physically mixing the preparation raw materials and defoaming to obtain the toothpaste.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] The toothpaste prepared by the present invention has a relatively good anti-sensitivity effect. The method for treating dentin sensitivity can be to apply a blocking material on the dentin surface to seal the exposed dentin tubules. The toothpaste prepared by the present invention has a relatively good blocking effect on the dental tubules, and the calendula extract, chamomile extract, propolis extract, tea extract, prickly ash extract and mint extract have a certain synergistic effect on the above effect. At the same time, the toothpaste prepared by the present invention also has the effect of refreshing breath. DETAILED DESCRIPTION

[0031] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0032] The sources of the functional ingredients contained in the products involved in the following embodiments and comparative examples are as follows (only the functional ingredients are reflected, and the necessary auxiliary ingredients contained in other commercially available raw materials are not repeated):

[0033] Calendula officinalis extract was purchased from Jingjiang Shengjin Technology Co., Ltd. under the trade name of Calendula officinalis extract;

[0034] Chamomile extract was purchased from Jingjiang Shengjin Technology Co., Ltd. under the trade name of Chamomile Extract;

[0035] Propolis extract was purchased from Jingjiang Shengjin Technology Co., Ltd. under the trade name of propolis extract;

[0036] The tea extract was purchased from Jingjiang Shengjin Technology Co., Ltd. under the trade name of tea extract;

[0037] Zanthoxylum bungeanum extract was purchased from Jingjiang Shengjin Technology Co., Ltd. under the trade name Zanthoxylum bungeanum extract;

[0038] The mint extract was purchased from Jingjiang Shengjin Technology Co., Ltd. under the trade name of mint extract;

[0039] Hydroxypropyl methylcellulose was purchased from Hebi Fangrui Chemical Products Co., Ltd. under the trade name of hydroxypropyl methylcellulose;

[0040] Xanthan gum was purchased from Ordos Zhongxuan Biochemical Co., Ltd. under the trade name of xanthan gum RH;

[0041] Hydrated silica was purchased from Jiangsu Mingfan Biotechnology Co., Ltd. under the trade name of silicon dioxide (MII type);

[0042] Pumice was purchased from Huizhou Hongyu Technology Co., Ltd. under the trade name of pumice;

[0043] Zeolite was purchased from Huzhou Koting Biotechnology Co., Ltd. under the trade name of Zeolite;

[0044] Sodium cocoamidopropionate was purchased from Guangzhou Xingye Technology Co., Ltd. under the trade name Ucefactant AC-30S;

[0045] C8-C14 alkyl glucoside is a product purchased from Jiaxing Zanyu Technology Group Co., Ltd. under the trade name APG0814;

[0046] Polyethylene glycol-8 is a product purchased from Yangzi Petrochemical-BASF Co., Ltd. under the trade name of polyethylene glycol 400;

[0047] The flavor was purchased from Givaudan Fragrances & Fragrances (Shanghai) Co., Ltd. with the trade name BSN02009AAK14450 / 00.

[0048] Example 1

[0049] The present embodiment provides a composition with anti-allergic effect, which comprises, by weight, 1.5 parts of calendula extract, 2 parts of chamomile extract, 1 part of propolis extract, 1.5 parts of tea extract, 0.5 parts of Zanthoxylum bungeanum extract, and 2 parts of peppermint extract.

[0050] The preparation method thereof is as follows: physically mixing the preparation raw materials to obtain the product.

[0051] Example 2

[0052] The present embodiment provides a composition with anti-allergic effect, which comprises, by mass, 1 part of calendula extract, 3 parts of chamomile extract, 0.5 parts of propolis extract, 2 parts of tea extract, 0.1 parts of Zanthoxylum bungeanum extract, and 3 parts of peppermint extract.

[0053] The preparation method is similar to that of Example 1.

[0054] Example 3

[0055] The present embodiment provides a composition with anti-allergic effect, which comprises, by mass, 2 parts of calendula extract, 1 part of chamomile extract, 2 parts of propolis extract, 1 part of tea extract, 1 part of Zanthoxylum bungeanum extract, and 1 part of peppermint extract.

[0056] The preparation method is similar to that of Example 1.

[0057] Comparative Example 1

[0058] This comparative example provides a composition with anti-allergic effect, which is different from Example 1 only in that it does not contain calendula extract, and its reduced mass is proportionally distributed to the masses of chamomile extract, propolis extract, tea extract, prickly ash extract and mint extract.

[0059] The preparation method is similar to that of Example 1.

[0060] Comparative Example 2

[0061] This comparative example provides a composition with anti-allergic effect, which is different from Example 1 only in that it does not contain chamomile extract, and its reduced mass is proportionally distributed to the masses of calendula extract, propolis extract, tea extract, prickly ash extract and mint extract.

[0062] The preparation method is similar to that of Example 1.

[0063] Comparative Example 3

[0064] This comparative example provides a composition with anti-allergic effect, which is different from Example 1 only in that it does not contain propolis extract, and its reduced mass is proportionally distributed to the masses of calendula extract, chamomile extract, tea extract, prickly ash extract and mint extract.

[0065] The preparation method is similar to that of Example 1.

[0066] Comparative Example 4

[0067] This comparative example provides a composition with anti-allergic effect, which is different from Example 1 only in that it does not contain tea extract, and its reduced mass is proportionally distributed to the masses of calendula extract, chamomile extract, propolis extract, prickly ash extract and mint extract.

[0068] The preparation method is similar to that of Example 1.

[0069] Comparative Example 5

[0070] This comparative example provides a composition with anti-allergic effect, which is different from Example 1 only in that it does not contain Zanthoxylum bungeanum extract, and its reduced mass is proportionally distributed to the masses of calendula extract, chamomile extract, propolis extract, tea extract and mint extract.

[0071] The preparation method is similar to that of Example 1.

[0072] Comparative Example 6

[0073] This comparative example provides a composition with anti-allergic effect, which is different from Example 1 only in that it does not contain peppermint extract, and its reduced mass is proportionally distributed to the masses of calendula extract, chamomile extract, propolis extract, tea extract and Zanthoxylum bungeanum extract.

[0074] The preparation method is similar to that of Example 1.

[0075] Application Example 1

[0076] This application example provides a toothpaste with anti-sensitivity effect, which includes, by mass, 1 part of the anti-sensitivity composition of Example 1, 0.4 part of hydroxypropyl methylcellulose, 0.4 part of xanthan gum, 7 parts of hydrated silica, 6 parts of zeolite, 7 parts of pumice, 1.5 parts of sodium lauroyl sarcosinate, 1.5 parts of lauryl glucoside, 1.5 parts of sodium cocoamidopropionate, 1.5 parts of C8-C14 alkyl glucoside, 30 parts of sorbitol, 10 parts of polyethylene glycol-8, 0.6 part of xylitol, 0.6 part of trichlorogalactose, 0.9 part of flavor, 0.3 part of sodium fluoride, 0.2 part of sodium hydroxide, 0.3 part of sodium benzoate, 0.05 part of menthone glyceryl ketal, and 30 parts of water.

[0077] The preparation method comprises the following steps: physically mixing the raw materials and defoaming to obtain the product.

[0078] Application Example 2

[0079] This application example provides a toothpaste with anti-sensitivity effect, which includes, by mass, 2 parts of the anti-sensitivity composition of Example 2, 0.3 parts of hydroxypropyl methylcellulose, 0.3 parts of xanthan gum, 6 parts of hydrated silica, 6 parts of zeolite, 5 parts of pumice, 1 part of sodium lauroyl sarcosinate, 1 part of lauryl glucoside, 1 part of sodium cocoamidopropionate, 1 part of C8-C14 alkyl glucoside, 25 parts of sorbitol, 10 parts of polyethylene glycol-8, 0.5 parts of xylitol, 0.5 parts of trichlorogalactose, 1.5 parts of flavor, 0.1 parts of sodium fluoride, 0.1 parts of sodium hydroxide, 0.1 parts of sodium benzoate, 0.2 parts of menthone glyceryl acetal, and 35 parts of water.

[0080] The preparation method refers to Application Example 1.

[0081] Application Example 3

[0082] This application example provides a toothpaste with anti-sensitivity effect, which includes, by mass, 0.5 parts of the anti-sensitivity composition of Example 3, 0.6 parts of hydroxypropyl methylcellulose, 0.6 parts of xanthan gum, 7 parts of hydrated silica, 7 parts of zeolite, 8 parts of pumice, 2 parts of sodium lauroyl sarcosinate, 2 parts of lauryl glucoside, 2 parts of sodium cocoamidopropionate, 2 parts of C8-C14 alkyl glucoside, 35 parts of sorbitol, 10 parts of polyethylene glycol-8, 0.7 parts of xylitol, 0.7 parts of trichlorogalactose, 0.7 parts of flavor, 0.5 parts of sodium fluoride, 0.5 parts of sodium hydroxide, 0.5 parts of sodium benzoate, 0.1 parts of menthone glyceryl acetal, and 28 parts of water.

[0083] The preparation method refers to Application Example 1.

[0084] Comparative Application Examples 1-6

[0085] This comparative application example provides 6 toothpastes with anti-sensitivity effects, which differ from application example 1 only in that the composition of example 1 is replaced by the compositions of comparative examples 1-6 in equal amounts, and other ingredients and contents remain unchanged.

[0086] The preparation method refers to Application Example 1.

[0087] Test Example 1

[0088] Allergy test

[0089] Dentin hypersensitivity can be treated by applying blocking materials to the dentin surface to seal the exposed dentinal tubules. In this experiment, the contamination layer of bovine dentin slices was removed by acid etching and the opening of dentinal tubules was simulated to establish a repeatable dentin hypersensitivity research model, so as to objectively and accurately evaluate the effect of the test substance in blocking dentinal tubules.

[0090] 3.1 Preparation of dentin samples: Freshly extracted bovine incisors were cut and polished to make dentin blocks of approximately 5 mm × 5 mm × 2 mm in size. The blocks were then corroded with 40% orthophosphoric acid for 20 minutes, rinsed, and then corroded with 5% sodium hypochlorite for 5 minutes. Finally, they were ultrasonically cleaned with deionized water for 20 minutes and observed under a polarized light microscope to ensure that the dental tubules were fully exposed.

[0091] 3.2 Grouping: The same dentin sample was cut into two halves using a low-speed cutter, one half was used as the treated area of ​​the sample group, and the other half was used as the untreated area of ​​the control group.

[0092] 3.3 Preparation of artificial saliva: 0.380 g / L sodium chloride, 0.213 g / L calcium chloride dihydrate, 0.738 g / L potassium dihydrogen phosphate, 1.114 g / L potassium chloride, 2.200 g / L gastric mucin dissolved in deionized water, 1 mol / L sodium hydroxide to adjust the pH to 7.0, add water to make up, and store in a 4°C refrigerator for later use.

[0093] 3.4 Toothpaste slurry preparation: Prepare a uniformly mixed toothpaste slurry in a ratio of 1:1.6 (toothpaste: water).

[0094] 3.5 Treat the dentin samples with toothpaste slurry. Brush the teeth with a toothbrush for 3 minutes, rinse thoroughly with deionized water, and soak in 37°C artificial saliva for 55 minutes. Repeat the brushing for 3 minutes, rinse thoroughly with deionized water, and soak in 37°C artificial saliva overnight. Repeat this step for a total of 7 times, using an equal amount of toothpaste slurry for each brushing.

[0095] 3.6 The dentin samples after the cycle treatment were dried in a constant temperature drying oven at 25°C and then observed using a scanning electron microscope to count the exposed dental tubules C.

[0096] 3.7 Calculation of tubule occlusion rate R (%) in each group

[0097]

[0098] Table 1

[0099] Group Blockage rate (%) Application Example 1 94.44 Application Example 2 93.26 Application Example 3 92.11 Comparative application example 1 85.76 Comparative Application Example 2 83.89 Comparative Application Example 3 82.45 Comparative Application Example 4 81.16 Comparative Application Example 5 79.88 Comparative Application Example 6 76.76

[0100] It can be seen from the data in Table 1 that the toothpaste prepared by the present invention has a good anti-sensitivity effect and a good blocking effect on dental tubules, and the calendula extract, chamomile extract, propolis extract, tea extract, Zanthoxylum bungeanum extract and mint extract have a certain synergistic effect.

[0101] Test Example 2

[0102] Fresh breath effect test

[0103] Test principle: The main components of bad breath gas are volatile sulfides, including methyl mercaptan, hydrogen sulfide and dimethyl sulfide, which are produced by various reasons, about 90% of which come from the mouth. This experiment simulates the use of oral care products in vitro, cultivates the production of volatile sulfides in the oral saliva secretions of volunteers, and measures methyl mercaptan to evaluate the breath freshening effect.

[0104] Test method:

[0105] (1) Cultivating hydroxyapatite sheets overnight to form acquired biofilms;

[0106] (2) Control group: soaked in deionized water for 2 min, taken out and placed in a headspace bottle;

[0107] Sample group: soaked in toothpaste slurry for 2 minutes, taken out and placed in a headspace bottle;

[0108] Preparation method of toothpaste slurry: Mix the sample with water in a mass ratio of 1:3;

[0109] (3) Mix saliva with thioglycollate medium, and mix the hydroxyapatite sheets of the control group and the experimental group with 3 mL of saliva medium;

[0110] (4) Incubate overnight for 12 h and detect the methyl mercaptan peak area.

[0111] Table 2

[0112]

[0113]

[0114] It can be seen from the data in Table 2 that the toothpaste prepared by the present invention has the effect of refreshing breath, and the calendula extract, chamomile extract, propolis extract, tea extract, prickly ash extract and mint extract have a certain synergistic effect.

[0115] Test Example 3

[0116] Usage test

[0117] This test uses a consumer questionnaire to collect relevant evaluations of the product from healthy subjects 120 minutes after a single use of the test product under normal circumstances.

[0118] Test products: Application examples 1-3, comparative application examples 1-6.

[0119] Directions: Use 1g of toothpaste to brush your teeth for three minutes, 10 people per group.

[0120] Subject inclusion criteria:

[0121] (1) Healthy men and women, aged 18-60 years;

[0122] (2) Those who use toothpaste-based cleaning products;

[0123] (3) Be able to cooperate well with the experimenters and maintain a regular life during the study;

[0124] (4) Be able to read and understand all the contents of the informed consent form and voluntarily sign the informed consent form;

[0125] (5) Agree not to use any cosmetics, drugs or health products that may affect the results during the trial;

[0126] (6) Other corresponding inclusion criteria.

[0127] Exclusion criteria:

[0128] (1) Those with skin diseases that may affect the judgment of the test results;

[0129] (2) Those with highly allergic constitution;

[0130] (3) Those with a history of allergic reactions to cosmetics;

[0131] (4) Women who are pregnant, breastfeeding, or planning to become pregnant during the trial;

[0132] (5) Those with severe heart, liver, or kidney damage and severe immunodeficiency;

[0133] (6) People with mental illness, severe endocrine diseases, or those taking oral contraceptives;

[0134] (7) Those with significant nutritional disorders;

[0135] (8) Those who have participated in drug clinical trials or other trials within 30 days, or those who have systematically used drugs that may affect the trial results within the past week;

[0136] (9) Those who have taken oral or external cosmetic products that may affect the test results within 2 weeks;

[0137] (10) Those who are unable to cooperate with the experiment;

[0138] (11) Those who are considered by the researchers to be unsuitable for participation in this study;

[0139] The subjects' scores were recorded 5 minutes after using the sample, using a 5-point system, where 1 was strongly disagree, 2 was disagree, 3 was indifferent between agreement or disagreement, 4 was agree, and 5 was strongly agree.

[0140] The results are shown in Table 3, with one decimal place retained.

[0141] Table 3

[0142]

[0143] It can be seen from the data in Table 3 that the toothpaste prepared by the present invention has a good feeling of use, is comfortable to use, has a good effect of alleviating bad breath, and has a strong ability to clean teeth.

[0144] The applicant declares that the present invention uses the above-mentioned embodiments to illustrate a toothpaste with anti-sensitivity effect and a preparation method thereof, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0145] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0146] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A toothpaste with anti-allergic effect, characterized in that: The raw materials for preparing the toothpaste include an anti-sensitivity composition, a thickener, an abrasive, a foaming agent and water. The anti-sensitivity composition includes calendula extract, chamomile extract, propolis extract, tea extract, prickly ash extract and mint extract.

2. The toothpaste with anti-allergic effect according to claim 1, characterized in that: The raw materials for preparing the toothpaste include, by weight, 0.5-2 parts of an anti-sensitivity composition, 0.5-1.2 parts of a thickener, 17-23 parts of an abrasive, 4-8 parts of a foaming agent and 28-35 parts of water.

3. The toothpaste with anti-allergic effect according to claim 1 or 2, characterized in that: The anti-allergic composition comprises, by weight, 1-2 parts of calendula extract, 1-3 parts of chamomile extract, 0.5-2 parts of propolis extract, 1-2 parts of tea extract, 0.1-1 parts of prickly ash extract and 1-3 parts of peppermint extract.

4. The toothpaste with anti-allergic effect according to any one of claims 1 to 3, characterized in that: The foaming agent includes any one or a combination of at least two of sodium lauroyl sarcosinate, lauryl glucoside, sodium cocoamidopropionate or C8-C14 alkyl glucoside; Preferably, the abrasive comprises any one of hydrated silica, zeolite or pumice, or a combination of at least two thereof; Preferably, the thickener comprises hydroxypropyl methylcellulose and / or xanthan gum.

5. The toothpaste with anti-allergic effect according to any one of claims 1 to 4, characterized in that: The raw materials for preparing the toothpaste further include any one of a moisturizer, a sweetener, a fragrance, an anti-caries agent, a pH adjuster, a preservative, and a cooling agent, or a combination of at least two of them.

6. The toothpaste with anti-allergic effect according to claim 5, characterized in that: The raw materials for preparing the toothpaste include, by weight, any one of 35-45 parts of moisturizer, 1-1.5 parts of sweetener, 0.7-1.5 parts of fragrance, 0.1-0.5 parts of anti-caries agent, 0.1-0.5 parts of pH adjuster, 0.1-0.5 parts of preservative, and 0.05-0.2 parts of cooling agent, or a combination of at least two of them.

7. The toothpaste with anti-allergic effect according to claim 5 or 6, characterized in that: The moisturizer includes sorbitol and / or polyethylene glycol-8; Preferably, the sweetener comprises xylitol and / or galactosamine.

8. The toothpaste with anti-sensitivity effect according to any one of claims 5 to 7, characterized in that: The aromatic agent includes essence; Preferably, the moth repellent comprises sodium fluoride.

9. The toothpaste with anti-sensitivity effect according to any one of claims 5 to 8, characterized in that: The pH adjuster includes sodium hydroxide; Preferably, the preservative comprises sodium benzoate; Preferably, the cooling agent comprises menthone glycerol ketal.

10. A method for preparing a toothpaste with anti-allergic effect according to any one of claims 1 to 9, characterized in that: The preparation method comprises: physically mixing the preparation raw materials and defoaming to obtain the product.

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