A rat restraining device based on biological evaluation of medical instruments

Abstract

The application discloses a rat fixing device based on biological evaluation of medical instruments. The device comprises an operation panel, a fixing cover, a sliding sheet and a sliding groove. A rectangular opening is designed in the center of the base of the operation panel, which is specially used for abdominal cavity injection operation of rats. The rat fixing cover is divided into four sections and is arranged on the operation panel. The two sides of the fixing cover are provided with the sliding sheets. The shape of the two sliding sheets after being spliced together is the same as that of the fixing cover. The lower end of the sliding sheet is in contact with the operation panel, and the sliding groove is arranged at the contact part. The rat fixing device can effectively adjust the size, so that rats with different body types can be effectively fixed, and the smooth operation of the test is ensured. The device is convenient to operate and stable in rat fixing.

Description

Technical Field

[0001] This invention belongs to the field of animal testing technology and relates to an adjustable rat restraint device for testing, particularly a restraint device that facilitates tail vein blood collection, injection, intramuscular injection in the forelimbs and hindlimbs, subcutaneous injection in the back, and intraperitoneal injection of rats. Background Technology

[0002] Safety, efficacy, and toxicological evaluation tests of medical devices all require strict quality control, and the accuracy of test results is a crucial indicator required by the industry. Laboratory animals are used in teaching, research, production, and testing, and are widely applied in fields such as biomedicine, medical devices, and scientific research and teaching. Among these, rats are the most widely used and frequently employed laboratory animals in the biological evaluation standards for medical devices. Effective restraint of rats during experiments is essential to ensure the scientific validity, accuracy, and stability of experimental results. Currently, commonly used laboratory restraint devices are not adjustable in size, leading to problems such as loose restraint and insecure fixation for rats of different sexes and ages. This hinders experimental procedures and seriously affects the accuracy of test results. Particularly during subacute / subacute systemic toxicity tests, insecure restraint severely impacts the administration of extracts via the tail vein, making the drug delivery process difficult; it also causes the extract to be injected into the tail tissue, resulting in insufficient dosage and ultimately affecting the scientific validity of the experimental results. Furthermore, due to the large size and aggressive nature of rats, effective restraint ensures the safety of laboratory technicians.

[0003] In summary, rat restraint devices are crucial for the smooth conduct of experimental procedures, the accuracy of experimental results, and the safety of experimental technicians. Therefore, a good and effective restraint device is an indispensable tool in rat experiments.

[0004] Currently, some restraint devices on the market have the following drawbacks: 1) Commonly used restraint devices are not adjustable, making it difficult to adapt to rats of different ages, sexes, and sizes. This inability to effectively control the restraint status of rats during experiments affects the experimental procedure and reduces the accuracy of results. 2) Commonly used restraint devices have a small rear opening, making it difficult for larger rats to enter, while an excessively large rear opening cannot effectively restrain the rats. 3) Some restraint devices only have openings at both ends of the fixation cover, severely limiting toxicological evaluations of administration via the back and abdomen. Summary of the Invention

[0005] Since rats are one of the species suitable for safety, efficacy, and toxicology experiments in the biological evaluation system of medical devices, and strict quality control is required in routine animal experiments, both direct contact with samples and indirect contact via extracts necessitate strict dosage control. Stable and effective restraint of animals is crucial for ensuring accurate dosage. Therefore, the restraint device needs to effectively adapt and fix rats of different sizes, sexes, and ages, ensuring the effectiveness of the restraint and addressing the issue of unstable restraint during experiments. Furthermore, this invention incorporates multiple openings in the restraint cover and device base, ensuring the restraint device is suitable for various experimental procedures, such as subcutaneous implantation in the rat's back, muscle implantation in the leg, and intraperitoneal injection.

[0006] The technical solution of this invention is as follows.

[0007] A rat restraint device based on medical device biological evaluation includes an operation panel, a fixation cover, sliding plates, and a sliding groove. The operation panel base has a rectangular opening in the center, specifically designed for intraperitoneal injection of rats. The rat fixation cover is divided into four sections, each set on the operation panel. Sliding plates are provided on both sides of the fixation cover. The shape of the sliding plates when they are joined together is the same as that of the fixation cover. The lower end of the sliding plate contacts the operation panel, and a sliding groove is provided at the contact part.

[0008] Furthermore, the fixing cover has a semi-cylindrical structure.

[0009] Furthermore, the fixing cover includes a first fixing cover, a second fixing cover, a third fixing cover, and a fourth fixing cover; the first fixing cover, the second fixing cover, the third fixing cover, and the fourth fixing cover are respectively disposed on the operation panel.

[0010] Furthermore, the front end of the first fixing cover is equipped with stainless steel wire mesh.

[0011] Furthermore, two sliding pieces are respectively provided between the first fixed cover and the second fixed cover, and between the second fixed cover and the third fixed cover. The shape of the sliding pieces after being spliced ​​together is the same as that of the semi-cylindrical fixed cover. The lower end of the sliding piece contacts the operation panel, and a stabilizing groove is provided in the contact part.

[0012] Each pair of opposing sliders is equipped with a fixed short rod and a long, rigid caliper.

[0013] Furthermore, the sliding piece is a first sliding piece, a second sliding piece, a third sliding piece, and a fourth sliding piece, wherein the first sliding piece and the third sliding piece are disposed between the first fixed cover and the second fixed cover; and the second sliding piece and the fourth sliding piece are disposed between the second fixed cover and the third fixed cover.

[0014] Furthermore, the slide groove is a first slide groove, a second slide groove, a third slide groove, and a fourth slide groove; the first slide groove is connected to a first sliding piece; the second slide groove is connected to a second sliding piece; the third slide groove is connected to a third sliding piece; and the fourth slide groove is connected to a fourth sliding piece.

[0015] Furthermore, a slot is designed between the third and fourth fixing covers for inserting a specially designed semi-circular card; the card has a pre-set positioning hole specifically for securing the rat's tail; a small hole is provided at the top of the card for inserting a long screw for connection. Simultaneously, a screw hole is also provided at the upper rear of the third fixing cover to securely fix the semi-circular card between the third and fourth fixing covers using screws, ensuring the stability of the restraint.

[0016] Furthermore, observing the device from a top view, the first side opening, the third side opening, the second side opening, and the fourth side opening are located on the right and left sides of the second fixing cover, and on the right and left sides of the third fixing cover, respectively, which facilitates intramuscular injection of the rat's left and right forelimbs and left and right hindlimbs.

[0017] Furthermore, the bottom of the operation panel is provided with four suction cups, namely the first suction cup, the second suction cup, the third suction cup and the fourth suction cup.

[0018] Compared with the prior art, the advantages of this invention are:

[0019] The invention solves the problem of restraint during rat tail vein injection and blood collection, subcutaneous implantation, intraperitoneal injection, and intramuscular injection in the limbs. The restraint device can be effectively adjusted in size so that rats of different sizes can be effectively restrained, ensuring the smooth progress of the experimental operation. It is easy to operate and provides relatively stable restraint for rats. Attached Figure Description

[0020] Figure 1 This is a three-dimensional diagram of a rat restraint device.

[0021] Figure 2 This is a top view of a rat restraint device.

[0022] Figure 3 This is a left view of the rat restraint device.

[0023] Figure 4 This is a right view of the rat restraint device.

[0024] Figure 5 It is a bottom-up view taken from the bottom up.

[0025] Figure 6 This is the front view of slider 2 and slider 4.

[0026] The markings in the diagram are: First fixed cover 1, Second fixed cover 2, Third fixed cover 3, Fourth fixed cover 4, First slider 5, Second slider 6, Third slider 7, Fourth slider 8, First slide groove 9, Second slide groove 10, Third slide groove 11, Fourth slide groove 12, Operation panel 13, Card 14, Rectangular opening of fixed cover 15, First side opening 16, Second side opening 17, First suction cup 18, Second suction cup 19, Third side opening 20, Fourth side opening 21, Third suction cup 22, Fourth suction cup 23, Rectangular opening 24, Fixed short rod 25, Long strip rigid caliper 26. Detailed Implementation

[0027] This embodiment mainly comprises two parts: a fixing panel and an operating panel. Suction cups are mounted at each of the four corners of the back panel to secure the base. A rectangular opening is designed in the center of the base, specifically for intraperitoneal injection procedures on rats. The rat restraint cover is divided into four sections, each fixed to the operating panel; each section is a semi-cylindrical structure. The specific design is as follows:

[0028] The front end of the first fixed cover 1 is equipped with stainless steel wire mesh.

[0029] Two sliding plates are designed between the first fixed cover 1 and the second fixed cover 2, and between the second fixed cover 2 and the third fixed cover 3. The shape of these sliding plates when they are joined together is the same as that of the semi-cylindrical fixed cover. The lower end of the sliding plate contacts the operation panel, and a stabilizing groove is provided at the contact part.

[0030] The second fixation cover 2 is designed with a rectangular opening for subcutaneous injection on the back of the rat. At the same time, the second fixation cover 2 has two rectangular first side openings 16 and third side openings 20 on each side near the base, so that the rat's forelimbs can be extended to facilitate operations such as intramuscular injection in the forelimbs.

[0031] The third fixing cover 3 also has two rectangular openings on each side near the base, so that the rat's hind limbs can be extended to facilitate operations such as intramuscular injection in the hind limbs.

[0032] A long, rigid caliper is provided at the upper end of the second slider 6 and the first slider 5. This caliper can be opened and closed around one end. A semi-circular locking hole is designed at the lower end of the caliper every 0.5cm. A fixing short rod is provided at the upper end of the fourth slider 8 and the third slider 7, which is used to connect and fix it to the long caliper at the upper end of the right slider.

[0033] A slot is designed between the third fixing cover 3 and the fourth fixing cover 4 for inserting a specially designed semi-circular card. This card has pre-drilled positioning holes specifically for securing the rat's tail. A small hole is provided at the top of the card for inserting a long screw for connection. Simultaneously, a screw hole is also provided at the upper rear of the third fixing cover 3 to securely fix the semi-circular card between the third fixing cover 3 and the fourth fixing cover 4, ensuring the restraint's stability.

[0034] The specific structure is as follows:

[0035] like Figures 1-6 As shown, it includes an operation panel 13, a fixing cover, sliding plates, and sliding grooves. The operation panel 13 has a rectangular opening 24 in the center of its base, specifically for intraperitoneal injection in rats. The second rectangular opening 24 is the lower opening of the device, also for intraperitoneal injection. The fixing cover is a semi-cylindrical structure. The rat fixing cover is divided into four sections, each set on the operation panel. Sliding plates are provided on both sides of the fixing cover. The shape of the sliding plates after being joined in pairs is the same as that of the fixing cover. The lower end of the sliding plate contacts the operation panel 13, and a sliding groove is provided at the contact point.

[0036] Specifically, the fixing cover includes a first fixing cover 1, a second fixing cover 2, a third fixing cover 3, and a fourth fixing cover 4; the first fixing cover 1, the second fixing cover 2, the third fixing cover 3, and the fourth fixing cover 4 are respectively mounted on the operation panel. The second fixing cover 2 has a rectangular opening 15, specifically the upper opening at the front end of the device, for subcutaneous injection on the back. The front end of the first fixing cover 1 is fitted with a stainless steel wire mesh. Two sliding plates are respectively provided between the first fixing cover 1 and the second fixing cover 2, and between the second fixing cover 2 and the third fixing cover 3. The shape of the sliding plates after being spliced ​​together is the same as that of the semi-cylindrical fixing cover; the lower end of the sliding plate contacts the operation panel 13, and a stabilizing groove is provided at the contact part; a fixing short rod 25 and a long strip of rigid caliper 26 are respectively provided on the two opposing sliding plates. The sliding pieces are a first sliding piece 5, a second sliding piece 6, a third sliding piece 7, and a fourth sliding piece 8, wherein the first sliding piece 5 and the third sliding piece 7 are disposed between the first fixing cover 1 and the second fixing cover 2; the second sliding piece 6 and the fourth sliding piece 8 are disposed between the second fixing cover 2 and the third fixing cover 3. The sliding grooves are a first sliding groove 9, a second sliding groove 10, a third sliding groove 11, and a fourth sliding groove 12; the first sliding groove 9 is connected to the first sliding piece 5; the second sliding groove 10 is connected to the second sliding piece 6; the third sliding groove 11 is connected to the third sliding piece 7; and the fourth sliding groove 12 is connected to the fourth sliding piece 8. A slot is designed between the third fixing cover 3 and the fourth fixing cover 4 for inserting a specially made semi-circular card 14; the card 14 has a pre-set positioning hole specifically for fixing the tail of the rat; a small hole is provided at the upper end of the card 14 for inserting a long screw for connection. Meanwhile, screw holes are also provided at the upper rear of the third fixing cover 3 so that the semi-circular card can be firmly fixed between the third fixing cover 3 and the fourth fixing cover 4 by screws, thus ensuring the stability of the fixing.

[0037] like Figures 3-4 As shown, the device is viewed from above. The first side opening 16, the third side opening 20, the second side opening 17, and the fourth side opening 21 are located on the right and left sides of the second fixing cover 2 and the right and left sides of the third fixing cover 3, respectively, which facilitates intramuscular injection of the left and right forelimbs and left and right hindlimbs of the rat.

[0038] like Figure 5 As shown, the bottom of the operation panel 13 is provided with four suction cups, namely the first suction cup 18, the second suction cup 19, the third suction cup 22 and the fourth suction cup 23.

[0039] Example 1

[0040] The adjustable rat restraint described in this embodiment includes: an operation panel, a suction cup, a fixing cover, a slider, a sliding groove, calipers, and a card;

[0041] The base is provided with two sets of sliding grooves symmetrically arranged relative to the center line of the long axis of the base, and the sliding grooves are parallel to the short axis.

[0042] The suction cups are located at the four corners of the base.

[0043] The movable slide is located between the first fixed cover 1 and the second fixed cover 2, and between the second fixed cover 2 and the third fixed cover 3. The lower end of the slide matches the slide groove. The slide can move left and right along the slide groove and be fixed up and down. During use, when the slide moves to the appropriate position, the caliper at the upper end of the slide can effectively fix the slide.

[0044] The semi-circular card is located between the third fixing cover 3 and the fourth fixing cover 4. A semi-circular hole is reserved at the lower end of the card, through which the rat's tail passes to facilitate tail vein injection.

[0045] The first fixing cover 1 has a wire mesh in front, which serves to restrain the rats while ensuring unobstructed breathing.

[0046] The procedure for tail vein injection using a rat restraint device according to this invention patent is as follows:

[0047] 1. Remove the card and slider, and place the rat in from the rear end of the fourth fixation cover 4.

[0048] 2. When the rat's head enters the appropriate position of the first fixing cover 1, move the slider. When the slider moves to a position that can just fix the rat, close the caliper at the top of the slider to fix the slider.

[0049] 3. Make the rat's tail extend out of the fourth fixing cover 4, insert the semi-circular card between the third fixing cover 3 and the fourth fixing cover 4, and fix the card to the third fixing cover 3 with a nut.

[0050] 4. The tail vein injection can be performed using the extended rat tail.

[0051] Example 2

[0052] The movable slide is located between the first fixed cover 1 and the second fixed cover 2, and between the second fixed cover 2 and the third fixed cover 3. The lower end of the slide matches the slide groove. The slide can move left and right along the slide groove and be fixed up and down. During use, when the slide moves to the appropriate position, the caliper at the upper end of the slide can effectively fix the slide.

[0053] The second fixing cover 2 is designed with a rectangular opening. When the rat's back test site moves to the rectangular opening, the slider is moved to the appropriate position, the caliper at the top of the slider is closed, and the slider is fixed.

[0054] The semi-circular card is located between the third fixing cover 3 and the fourth fixing cover 4. A semi-circular hole is reserved at the lower end of the card, through which the rat's tail is passed to stabilize the rat.

[0055] The procedure for subcutaneous injection of the rat restraint device according to this invention patent is as follows:

[0056] 1. Remove the card and slider, and place the rat in from the rear end of the fourth fixation cover 4.

[0057] 2. When the subcutaneous injection site on the rat's back moves to the rectangular opening of the second fixation cover 2, move the slider. When the slider moves to a position that can just fix the rat, close the caliper at the top of the slider to fix the slider.

[0058] 3. Make the rat's tail extend out of the fourth fixing cover 4, insert the semi-circular card between the third fixing cover 3 and the fourth fixing cover 4, and fix the card to the third fixing cover 3 with a nut.

[0059] 4. Once the rats are effectively kept in place, subcutaneous injection can be performed on the back of the rat.

[0060] Example 3

[0061] The movable slide is located between the first fixed cover 1 and the second fixed cover 2, and between the second fixed cover 2 and the third fixed cover 3. The lower end of the slide matches the slide groove. The slide can move left and right along the slide groove and be fixed up and down. During use, when the slide moves to the appropriate position, the caliper at the upper end of the slide can effectively fix the slide.

[0062] Two rectangular openings are designed on each of the left and right sides of the second fixing cover 2 near the base to facilitate the rat's forelimbs to extend and to facilitate operations such as intramuscular injection in the rat's forelimbs. Similarly, two rectangular openings are designed on each of the left and right sides of the third fixing cover 3 near the base to facilitate the rat's hindlimbs to extend and to facilitate operations such as intramuscular injection in the rat's hindlimbs.

[0063] The semi-circular card is located between the third fixing cover 3 and the fourth fixing cover 4. A semi-circular hole is reserved at the lower end of the card, through which the rat's tail is passed to stabilize the rat.

[0064] The procedure for intramuscular injection into the forelimbs and hindlimbs of the rat restraint device, as described in this invention patent, is as follows:

[0065] 1. Remove the card and slider, and place the rat in from the rear end of the fourth fixation cover 4.

[0066] 2. When the rat's forelimb or hindlimb moves to the rectangular opening on the left or right side of the second fixing cover 2 or the third fixing cover 3 near the base, move the slider. When the slider moves to a position that can just fix the rat, close the caliper at the top of the slider to fix the slider.

[0067] 3. Make the rat's tail extend out of the fourth fixing cover 4, insert the semi-circular card between the third fixing cover 3 and the fourth fixing cover 4, and fix the card to the third fixing cover 3 with a nut.

[0068] 4. Once the rat is effectively secured, pull out the rat's forelimb or hindlimb from the rectangular openings near the base on both sides of the second or third fixation cover 2 to administer an intramuscular injection to the forelimb or hindlimb.

[0069] Example 4

[0070] The movable slide is located between the first fixed cover 1 and the second fixed cover 2, and between the second fixed cover 2 and the third fixed cover 3. The lower end of the slide matches the slide groove. The slide can move left and right along the slide groove and be fixed up and down. During use, when the slide moves to the appropriate position, the caliper at the upper end of the slide can effectively fix the slide.

[0071] The base has a rectangular opening in the middle for intraperitoneal injection in rats. When the injection site on the rat's abdomen is moved to the appropriate position of the base opening, the slider is moved to the appropriate position, and the caliper at the top of the slider is closed to fix the slider.

[0072] The semi-circular card is located between the third fixing cover 3 and the fourth fixing cover 4. A semi-circular hole is reserved at the lower end of the card, through which the rat's tail is passed to stabilize the rat.

[0073] The procedure for intraperitoneal injection of the rat restraint device according to this invention patent is as follows:

[0074] 1. Remove the card and slider, and place the rat in from the rear end of the fourth fixation cover 4.

[0075] 2. When the injection site on the rat's abdomen is moved to the appropriate position of the base opening, move the slider to the appropriate position, close the caliper at the top of the slider, and fix the slider.

[0076] 3. Make the rat's tail extend out of the fourth fixing cover 4, insert the semi-circular card between the third fixing cover 3 and the fourth fixing cover 4, and fix the card to the third fixing cover 3 with a nut.

[0077] 4. Once the rat is effectively restrained, the restraint device can be flipped over to administer the intraperitoneal injection.

Claims

1. A rat restraint device based on medical device biological evaluation, characterized in that, The system includes an operation panel (13), a fixing cover, sliding plates, and a sliding groove; the operation panel (13) has a rectangular opening (24) in the center of its base, specifically for intraperitoneal injection of rats; the rat fixing cover is divided into four sections, which are respectively set on the operation panel; sliding plates are provided on both sides of the fixing cover; the shape of the sliding plates after being spliced ​​in pairs is the same as that of the fixing cover; the lower end of the sliding plate contacts the operation panel (13), and a sliding groove is provided in the contact part; the fixing cover is a semi-cylindrical structure; the fixing cover includes a first fixing cover (1), a second fixing cover (2), and a third fixing cover (3). The first fixed cover (1), the second fixed cover (2), the third fixed cover (3) and the fourth fixed cover (4) are respectively set on the operation panel; the second fixed cover (2) has a rectangular opening (15); two sliding pieces are respectively set between the first fixed cover (1) and the second fixed cover (2), and between the second fixed cover (2) and the third fixed cover (3), and the shape of the sliding pieces after being spliced ​​together is the same as that of the semi-cylindrical fixed cover; the lower end of the sliding piece contacts the operation panel (13), and a stable sliding groove is provided in the contact part; Two opposing sliders are respectively equipped with a fixed short rod (25) and a long strip rigid caliper (26). A slot is designed between the third fixing cover (3) and the fourth fixing cover (4) for inserting a specially made semi-circular card (14); the card (14) has a positioning hole for fixing the tail of the rat; a small hole is provided at the top of the card (14); at the same time, a screw hole is also provided at the rear of the top of the third fixing cover (3) so that the semi-circular card can be firmly fixed between the third fixing cover (3) and the fourth fixing cover (4) by screws, thus ensuring the stability of the restraint.

2. The rat restraint device based on medical device biological evaluation according to claim 1, characterized in that, The front end of the first fixed cover (1) is equipped with stainless steel wire mesh.

3. The rat restraint device based on medical device biological evaluation according to claim 1, characterized in that, The sliding pieces are a first sliding piece (5), a second sliding piece (6), a third sliding piece (7), and a fourth sliding piece (8), wherein the first sliding piece (5) and the third sliding piece (7) are disposed between the first fixed cover (1) and the second fixed cover (2); the second sliding piece (6) and the fourth sliding piece (8) are disposed between the second fixed cover (2) and the third fixed cover (3).

4. The rat restraint device based on medical device biological evaluation according to claim 1, characterized in that, The slides are a first slide (9), a second slide (10), a third slide (11) and a fourth slide (12); the first slide (9) is connected to the first slide (5); the second slide (10) is connected to the second slide (6); the third slide (11) is connected to the third slide (7); and the fourth slide (12) is connected to the fourth slide (8).

5. The rat restraint device based on medical device biological evaluation according to claim 1, characterized in that, The first side opening (16), the third side opening (20), the second side opening (17), and the fourth side opening (21) are located on the right and left sides of the second fixing cover (2) and the right and left sides of the third fixing cover (3), respectively, which facilitates intramuscular injection of the left and right forelimbs and left and right hindlimbs of the rat.

6. The rat restraint device based on medical device biological evaluation according to claim 1, characterized in that, The bottom of the operation panel (13) is provided with four suction cups, namely the first suction cup (18), the second suction cup (19), the third suction cup (22) and the fourth suction cup (23).

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