Traditional Chinese medicine composition for treating herpes zoster and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides a traditional Chinese medicine composition for treating herpes zoster and a preparation method thereof. According to the traditional Chinese medicine composition, raw radix astragali, white ginseng, fructus lycii, rhizoma polygonati, glossy privet fruit, semen plantaginis, semen cuscutae, cortex moutan, ginger processed cortex magnoliae officinalis, frankincense, myrrh and raw radix glycyrrhizae are adopted as raw materials and are subjected to proper weight proportioning; wherein the raw radix astragali and the white ginseng have the effects of invigorating spleen, replenishing qi and tonifying the acquired root; the fructus lycii, the glossy privet fruit, the semen plantaginis and the semen cuscutae have the effects of tonifying kidney, nourishing yin and warming yang, and tonify the innate root; polygonatum sibiricum has the effects of antioxidant activity, immunity regulation, nerve nutrition, fatigue resistance and the like; the ginger officinal magnolia bark has the effects of regulating qi and relieving pain; boswellia carteri, myrrh and rhizoma corydalis are medicines for regulating qi, promoting blood circulation, removing blood stasis and relieving pain. Cortex moutan can cool blood, promote blood circulation, stop pain, nourish yin and clear heat. The liquorice can invigorate the spleen, replenish qi and reconcile the effects of the medicines. Under the synergistic effect of all the medicine components, the effects of tonifying middle-Jiao and Qi and nourishing Yin and relieving pain are jointly achieved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating herpes zoster and a preparation method thereof. Background Art

[0002] Herpes zoster (HZ) is caused by the reactivation of varicella-zoster virus (VZV). It is a common infectious skin disease. Its main clinical features are: erythema, blisters or papules are distributed in a band along the unilateral peripheral nerve, often accompanied by obvious neuralgia; and after the herpes subsides, some viruses still lurk in the ganglion, causing pain in the invaded area, which is called postherpetic neuralgia. The pain can range from mild to extreme. The pain is continuous, intermittent or induced by very small stimulation. As a stubborn disease in dermatology, postherpetic neuralgia brings great physical pain and psychological burden to patients, seriously affecting their quality of life. The treatment goal of herpes zoster is to relieve acute pain, limit the spread of skin lesions, shorten the duration of skin lesions, and prevent or alleviate postherpetic neuralgia and other acute or chronic complications.

[0003] At present, the treatment schemes for herpes zoster at home and abroad are relatively consistent, and most of them use antiviral, nerve nutrition, analgesic, and corticosteroid hormone symptomatic treatment, and most of its clinical symptoms can be relieved. However, during the treatment of Western medicine, patients still need to endure great pain, and Western medicine has large side effects, poor analgesic effect, uncertain antiviral efficacy, and most of them have some adverse reactions to the body, causing discomfort. In particular, some patients will be left with postherpetic neuralgia (PHN), because PHN is a stubborn disease that lasts for a long time and seriously affects the quality of life of patients, and it is difficult to treat. Summary of the invention

[0004] In order to solve the above problems existing in the prior art, the present invention provides a Chinese medicine composition for treating herpes zoster with good therapeutic effect and small side effects and a preparation method thereof.

[0005] The technical solution adopted by the present invention is: The first aspect of the present invention provides a traditional Chinese medicine composition for treating herpes zoster, the raw material components comprising: 10-30 weight parts of raw astragalus, 5-15 weight parts of white ginseng, 10-30 weight parts of wolfberry, 5-15 weight parts of polygonatum, 20-40 weight parts of glossy privet, 5-15 weight parts of plantago, 10-20 weight parts of dodder seed, 5-15 weight parts of moutan bark, 5-15 weight parts of ginger magnolia bark, 5-10 weight parts of frankincense, 5-10 weight parts of myrrh, 5-15 weight parts of corydalis, and 5-15 weight parts of raw licorice.

[0006] It is further preferred that the raw material components of the Chinese medicine composition for treating herpes zoster include: 15-25 weight parts of raw astragalus, 8-12 weight parts of white ginseng, 15-25 weight parts of wolfberry, 8-12 weight parts of polygonatum, 15-25 weight parts of Ligustrum lucidum, 8-12 weight parts of plantain seeds, 12-18 weight parts of dodder seeds, 8-12 weight parts of moutan bark, 8-12 weight parts of magnolia bark, 6-8 weight parts of frankincense, 6-8 weight parts of myrrh, 8-12 weight parts of corydalis, and 8-12 weight parts of raw licorice.

[0007] It is further preferred that the raw material components of the Chinese medicine composition for treating herpes zoster include: 20 parts by weight of raw astragalus, 10 parts by weight of white ginseng, 20 parts by weight of wolfberry, 10 parts by weight of polygonatum, 30 parts by weight of glossy privet, 10 parts by weight of plantain seeds, 15 parts by weight of dodder seeds, 10 parts by weight of moutan bark, 10 parts by weight of magnolia bark, 7 parts by weight of frankincense, 7 parts by weight of myrrh, 10 parts by weight of corydalis, and 10 parts by weight of raw licorice.

[0008] The second aspect of the present invention provides a method for preparing the Chinese medicine composition for treating herpes zoster, comprising the following steps: (1) Raw astragalus, white ginseng, wolfberry, polygonatum, glossy privet, plantago and dodder seeds are taken according to weight, and ultrafinely ground to obtain ultrafine powders of each Chinese medicine; (2) taking the remaining raw material components by weight, crushing them, and mixing them thoroughly to obtain a Chinese medicine mixed powder; (3) adding water to the mixed Chinese medicine powder obtained in step (2), performing water extraction to obtain a water extract; (4) filtering and concentrating the aqueous extract of step (3) to obtain a concentrate; (5) The concentrate of step (4) is dried and ultrafinely ground in sequence, and then the ultrafine powders of the Chinese medicinal materials of step (1) are added and mixed thoroughly to obtain the Chinese medicinal composition for treating herpes zoster.

[0009] In step (1), the particle size of each Chinese medicine ultrafine powder is 1000-1500 mesh.

[0010] In step (3), the mass ratio of the Chinese medicine mixed powder to the added water is 1:4-1:8.

[0011] In step (3), the water extraction treatment time is 1-2 hours; In step (4), the concentration is concentrated under reduced pressure to a thick paste with a relative density of 1.30-1.35; In step (5), the drying temperature is 80-120°C.

[0012] In step (5), the particle size of the ultrafine powder obtained after ultrafine grinding is 1000-1500 mesh.

[0013] The application of the traditional Chinese medicine composition in preparing medicine for treating herpes zoster.

[0014] Raw Astragalus root is sweet and warm in nature. It can replenish qi and strengthen the exterior, promote diuresis and expel toxins, discharge pus, heal sores and promote tissue regeneration. It is used for qi deficiency and fatigue, poor appetite and loose stools, sinking of qi in the middle, chronic diarrhea and prolapse of the anus, bloody stool and metrorrhagia, spontaneous sweating due to exterior deficiency, edema due to qi deficiency, carbuncle that is difficult to heal, long-term ulcers that do not heal, blood deficiency and jaundice, internal heat and thirst; proteinuria in chronic nephritis, and diabetes.

[0015] White ginseng tastes sweet and slightly bitter, and is neutral in nature. It greatly replenishes vital energy, consolidates the body's constitution, promotes the production of body fluids, and calms the mind. It is used for women with metrorrhagia, postpartum hair loss, and long-term weakness; premature ejaculation and spermatorrhea, yin deficiency and night sweats, dizziness and headaches; fatigue caused by overwork, loss of appetite, fatigue, and nausea and vomiting.

[0016] Lycium barbarum is sweet and neutral in nature. It nourishes the liver and kidneys, improves the essence and improves eyesight. It is used for asthenia, loss of essence, soreness of waist and knees, dizziness and tinnitus, internal heat and thirst, blood deficiency and sallow complexion, and blurred vision.

[0017] Polygonatum sibiricum, sweet in taste, neutral in nature. It replenishes qi and nourishes yin, strengthens the spleen, moistens the lungs, and benefits the kidneys. It is used for spleen and stomach weakness, fatigue, dry mouth and poor appetite, dry cough due to lung deficiency, deficiency of essence and blood, and internal heat and thirst.

[0018] Fructus Ligustri Lucidi, sweet and bitter in taste, cool in nature. Nourishes the liver and kidneys, brightens eyesight and darkens hair. Used for vertigo, tinnitus, soreness of waist and knees, premature graying of hair, and blurred vision.

[0019] Plantago seed, sweet in taste, slightly cold in nature. It can clear away heat and promote diuresis, dissipate dampness and relieve stranguria, improve eyesight and eliminate phlegm. It is used for edema, painful stranguria due to heat, diarrhea due to summer heat and dampness, red and swollen eyes, and cough due to phlegm and heat.

[0020] Cuscuta chinensis is sweet and warm in nature. It nourishes the liver and kidneys, consolidates the essence and reduces urine, stabilizes the fetus, improves eyesight, and stops diarrhea. It is used for impotence and spermatorrhea, residual urine, enuresis and frequent urination, soreness of the waist and knees, blurred vision and tinnitus, kidney deficiency and fetal leakage, restless fetal movement, spleen and kidney deficiency diarrhea; external treatment of vitiligo.

[0021] Cortex Moutan, bitter and pungent, slightly cold in nature. Clears away heat and cools blood, promotes blood circulation and removes blood stasis. Used for fever-induced rash, hematemesis and epistaxis, night heat and morning coolness, no sweating and bone steaming, amenorrhea and dysmenorrhea, carbuncle, sore and toxicity, and pain from falls.

[0022] Ginger Magnolia Bark, bitter, pungent, warm in nature. It dries dampness and eliminates phlegm, relieves qi and relieves fullness. It is used for dampness stagnation, abdominal distension, vomiting and diarrhea, food accumulation and qi stagnation, abdominal distension and constipation, phlegm and fluid, wheezing and coughing.

[0023] Frankincense is pungent and bitter in taste and warm in nature. It can promote blood circulation and relieve pain. It is used for various pains in the heart and abdomen, muscle spasms, injuries from falls, swelling and pain from sores and carbuncles; it can be used externally to reduce swelling and promote tissue regeneration.

[0024] Myrrh, bitter in taste, neutral in nature. It can dissipate blood stasis and relieve pain, and can be used externally to reduce swelling and promote tissue regeneration. It is used to treat swelling and pain caused by contusions, swelling and pain caused by carbuncles, and pain in the chest and abdomen; it can be used externally to treat wounds that do not heal for a long time.

[0025] Yuanhu, pungent, bitter, warm in nature. It promotes blood circulation, promotes qi, and relieves pain. It is used for chest, flank, abdominal pain, amenorrhea, dysmenorrhea, postpartum blood stasis, and swelling and pain caused by falls.

[0026] Raw licorice root is sweet and neutral in nature. It nourishes the spleen and replenishes qi, clears away heat and detoxifies, removes phlegm and relieves cough, relieves pain, and harmonizes various medicines. It is used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncle, sore and ulcer, and relieves drug toxicity and potency.

[0027] The present invention has the following beneficial effects: The invention provides a Chinese medicine composition for treating herpes zoster, which adopts raw astragalus, white ginseng, wolfberry, polygonatum, glossy privet, plantago, dodder, moutan bark, ginger magnolia bark, frankincense, myrrh, corydalis and raw liquorice as raw materials and performs appropriate weight ratio; raw astragalus and white ginseng can invigorate the spleen and replenish qi, and replenish the acquired foundation; wolfberry, glossy privet, plantago and dodder have the effects of invigorating the kidney, nourishing yin and warming yang, and replenishing the innate foundation; polygonatum has antioxidant activity, regulates immunity, nourishes nerves, resists fatigue and the like; ginger magnolia bark has the effect of regulating qi and relieving pain; frankincense, myrrh and corydalis are all blood qi medicines, which are good at regulating qi, promoting blood circulation, removing blood stasis and relieving pain. Paeonia suffruticosa can not only cool blood, promote blood circulation and relieve pain, but also nourish yin and clear heat. Licorice can invigorate the spleen and replenish qi, and harmonize the effects of various medicines. Under the synergistic effect of the above-mentioned drug components, they play the effects of invigorating the middle qi, nourishing yin and relieving pain. Clinical effects have shown that the Chinese medicine composition of the present invention has good efficacy in treating postherpetic neuralgia with qi deficiency and yin damage syndrome, and has good safety, and is worthy of clinical promotion and application. DETAILED DESCRIPTION

[0028] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0029] Unless otherwise specified, the reagents involved in the specific embodiments of the present invention are all commercially available products and can be purchased through commercial channels.

[0030] In the following examples, 1 part by weight represents 1 g.

[0031] Example 1 This embodiment provides a Chinese medicine composition for treating herpes zoster, the raw material components comprising: 10 parts by weight of raw astragalus, 15 parts by weight of white ginseng, 10 parts by weight of wolfberry, 15 parts by weight of polygonatum, 20 parts by weight of glossy privet, 15 parts by weight of plantain seeds, 10 parts by weight of dodder seeds, 15 parts by weight of moutan bark, 5 parts by weight of magnolia bark, 10 parts by weight of frankincense, 5 parts by weight of myrrh, 15 parts by weight of corydalis, and 5 parts by weight of raw licorice.

[0032] The method for preparing the traditional Chinese medicine composition for treating herpes zoster comprises the following steps: (1) Raw astragalus, white ginseng, wolfberry, polygonatum, glossy privet, plantain and dodder seeds are taken according to weight, and after ultrafine grinding, the ultrafine powders of each Chinese medicine are obtained with a particle size of 1000 mesh; (2) taking the remaining raw material components by weight, crushing them, and mixing them thoroughly to obtain a Chinese medicine mixed powder; (3) adding 4 times the mass of water to the mixed powder of traditional Chinese medicine obtained in step (2), and subjecting the mixture to reflux extraction for 2 h to obtain a water extract; (4) filtering the aqueous extract of step (3), and concentrating under reduced pressure to a thick paste with a relative density of 1.30, which is the concentrate; (5) The concentrate of step (4) is first dried at 80° C., and then ultrafinely ground to obtain ultrafine powder with a particle size of 1000 mesh. The ultrafine powders of the Chinese medicinal materials of step (1) are then added and mixed thoroughly to obtain the Chinese medicinal composition for treating herpes zoster.

[0033] Example 2 This embodiment provides a Chinese medicine composition for treating herpes zoster, the raw material components comprising: 30 parts by weight of raw astragalus, 5 parts by weight of white ginseng, 30 parts by weight of wolfberry, 5 parts by weight of polygonatum, 40 parts by weight of glossy privet, 5 parts by weight of plantain seeds, 20 parts by weight of dodder seeds, 5 parts by weight of moutan bark, 15 parts by weight of magnolia bark, 5 parts by weight of frankincense, 10 parts by weight of myrrh, 5 parts by weight of corydalis, and 15 parts by weight of raw licorice.

[0034] The method for preparing the traditional Chinese medicine composition for treating herpes zoster comprises the following steps: (1) Raw astragalus, white ginseng, wolfberry, polygonatum, glossy privet, plantain and dodder seeds are taken according to weight, and after ultrafine grinding, the particle size of each Chinese medicine is obtained. Ultrafine powder; (2) taking the remaining raw material components by weight, crushing them, and mixing them thoroughly to obtain a Chinese medicine mixed powder; (3) adding 8 times the mass of water to the mixed powder of traditional Chinese medicine obtained in step (2), and subjecting it to reflux extraction for 1 hour. The reflux extraction is repeated twice, and the extracts are combined to obtain the water extract; (4) filtering the aqueous extract of step (3), and concentrating under reduced pressure to a thick paste with a relative density of 1.35, which is the concentrate; (5) The concentrate of step (4) is first dried at 120° C., and then ultrafinely ground to obtain ultrafine powder with a particle size of 1500 mesh. The ultrafine powders of the Chinese medicinal materials of step (1) are then added and mixed thoroughly to obtain the Chinese medicinal composition for treating herpes zoster.

[0035] Example 3 This embodiment provides a Chinese medicine composition for treating herpes zoster, the raw material components comprising: 15 parts by weight of raw astragalus, 12 parts by weight of white ginseng, 15 parts by weight of wolfberry, 12 parts by weight of polygonatum, 15 parts by weight of glossy privet, 12 parts by weight of plantain seeds, 12 parts by weight of dodder seeds, 12 parts by weight of moutan bark, 8 parts by weight of magnolia bark, 8 parts by weight of frankincense, 6 parts by weight of myrrh, 12 parts by weight of corydalis, and 8 parts by weight of raw licorice.

[0036] The method for preparing the traditional Chinese medicine composition for treating herpes zoster comprises the following steps: (1) Raw astragalus, white ginseng, wolfberry, polygonatum, glossy privet, plantain and dodder seeds are taken according to weight, and after ultrafine grinding, the particle size of each Chinese medicine is obtained. Ultrafine powder; (2) taking the remaining raw material components by weight, crushing them, and mixing them thoroughly to obtain a Chinese medicine mixed powder; (3) adding 6 times the mass of water to the mixed powder of traditional Chinese medicine obtained in step (2), and performing reflux extraction for 1.5 h. The reflux extraction is repeated twice, and the extracts are combined to obtain the water extract; (4) filtering the aqueous extract of step (3), and concentrating under reduced pressure to a thick paste with a relative density of 1.32, which is the concentrate; (5) The concentrate of step (4) is first dried at 100° C., and then ultrafinely ground to obtain ultrafine powder with a particle size of 1200 mesh. The ultrafine powders of the Chinese medicinal materials of step (1) are then added and mixed thoroughly to obtain the Chinese medicinal composition for treating herpes zoster.

[0037] Example 4 This embodiment provides a Chinese medicine composition for treating herpes zoster, the raw material components comprising: 25 parts by weight of raw astragalus, 8 parts by weight of white ginseng, 25 parts by weight of wolfberry, 8 parts by weight of polygonatum, 25 parts by weight of glossy privet, 8 parts by weight of plantain seeds, 18 parts by weight of dodder seeds, 8 parts by weight of moutan bark, 12 parts by weight of magnolia bark, 6 parts by weight of frankincense, 8 parts by weight of myrrh, 8 parts by weight of corydalis, and 12 parts by weight of raw licorice.

[0038] The method for preparing the traditional Chinese medicine composition for treating herpes zoster comprises the following steps: (1) Raw astragalus, white ginseng, wolfberry, polygonatum, glossy privet, plantain and dodder seeds are taken according to weight, and after ultrafine grinding, the particle size of each Chinese medicine is obtained. Ultrafine powder; (2) taking the remaining raw material components by weight, crushing them, and mixing them thoroughly to obtain a Chinese medicine mixed powder; (3) adding 6 times the mass of water to the mixed powder of traditional Chinese medicine obtained in step (2), and performing reflux extraction for 1.5 h. The reflux extraction is repeated twice, and the extracts are combined to obtain the water extract; (4) filtering the aqueous extract of step (3), and concentrating under reduced pressure to a thick paste with a relative density of 1.33, which is the concentrate; (5) The concentrate of step (4) is first dried at 100° C., and then ultrafinely ground to obtain ultrafine powder with a particle size of 1200 mesh. The ultrafine powders of the Chinese medicinal materials of step (1) are then added and mixed thoroughly to obtain the Chinese medicinal composition for treating herpes zoster.

[0039] Example 5 This embodiment provides a Chinese medicine composition for treating herpes zoster, the raw material components comprising: 20 parts by weight of raw astragalus, 10 parts by weight of white ginseng, 20 parts by weight of wolfberry, 10 parts by weight of polygonatum, 30 parts by weight of glossy privet, 10 parts by weight of plantain seeds, 15 parts by weight of dodder seeds, 10 parts by weight of moutan bark, 10 parts by weight of magnolia bark, 7 parts by weight of frankincense, 7 parts by weight of myrrh, 10 parts by weight of corydalis, and 10 parts by weight of raw licorice.

[0040] The method for preparing the traditional Chinese medicine composition for treating herpes zoster comprises the following steps: (1) Raw astragalus, white ginseng, wolfberry, polygonatum, glossy privet, plantain and dodder seeds are taken according to weight, and after ultrafine grinding, the particle size of each Chinese medicine is obtained. Ultrafine powder; (2) taking the remaining raw material components by weight, crushing them, and mixing them thoroughly to obtain a Chinese medicine mixed powder; (3) adding 6 times the mass of water to the mixed powder of traditional Chinese medicine obtained in step (2), and performing reflux extraction for 1.5 h. The reflux extraction is repeated twice, and the extracts are combined to obtain the water extract; (4) filtering the aqueous extract of step (3), and concentrating under reduced pressure to a thick paste with a relative density of 1.34, which is the concentrate; (5) The concentrate of step (4) is first dried at 100° C., and then ultrafinely ground to obtain ultrafine powder with a particle size of 1200 mesh. The ultrafine powders of the Chinese medicinal materials of step (1) are then added and mixed thoroughly to obtain the Chinese medicinal composition for treating herpes zoster.

[0041] Example 6 The difference between this comparative example and Example 5 is only the different preparation methods. The preparation method of this example is as follows: (1) Raw astragalus, white ginseng, wolfberry, polygonatum, glossy privet, plantain and dodder seeds are taken according to weight, and crushed to obtain powders of each Chinese medicine with a particle size of 120 mesh; (2) taking the remaining raw material components by weight, crushing them, and mixing them thoroughly to obtain a Chinese medicine mixed powder; (3) adding 6 times the mass of water to the mixed powder of traditional Chinese medicine obtained in step (2), and performing reflux extraction for 1.5 h. The reflux extraction is repeated twice, and the extracts are combined to obtain the water extract; (4) filtering the aqueous extract of step (3), and concentrating under reduced pressure to a thick paste with a relative density of 1.33, which is the concentrate; (5) The concentrate of step (4) is first dried at 100° C., and then pulverized to obtain a powder with a particle size of 120 meshes, and then the Chinese medicine powders of step (1) are added and mixed thoroughly to obtain the Chinese medicine composition for treating herpes zoster.

[0042] Comparative Example 1 The difference between this comparative example and Example 5 is the raw material composition. The mass ratio of raw astragalus, white ginseng, wolfberry, and polygonatum in the raw material components of this comparative example is 8:1:8:1, that is, 40 parts by weight of raw astragalus, 5 parts by weight of white ginseng, 40 parts by weight of wolfberry, and 5 parts by weight of polygonatum. The amount of other raw materials and the preparation method are the same as those in Example 1.

[0043] Comparative Example 2 The difference between this comparative example and Example 5 is the raw material composition. The mass ratio of raw astragalus, white ginseng, wolfberry, and polygonatum in the raw material components of this comparative example is 1:3:1:3, that is, 10 parts by weight of raw astragalus, 30 parts by weight of white ginseng, 10 parts by weight of wolfberry, and 30 parts by weight of polygonatum. The amount of other raw materials and the preparation method are the same as those in Example 1.

[0044] Comparative Example 3 The difference between this comparative example and Example 5 is only the preparation method. The preparation method of this comparative example is: (1) taking each raw material component by weight, and crushing them to obtain each Chinese medicine powder with a particle size of 120 mesh; (2) fully mixing the Chinese medicinal powders obtained in step (1) to obtain a Chinese medicinal mixed powder; (3) adding 6 times the mass of water to the mixed powder of traditional Chinese medicine obtained in step (2), and subjecting it to reflux extraction for 2 h. The reflux extraction is repeated twice, and the extracts are combined to obtain the water extract; (4) filtering the aqueous extract of step (3), and concentrating under reduced pressure to a thick paste with a relative density of 1.32, which is the concentrate; (5) The concentrate of step (4) is first dried at 100° C. and then crushed to obtain a Chinese medicine composition.

[0045] Experimental example The following clinical trials are used to further illustrate the therapeutic effects of the Chinese medicine compositions obtained in Examples 1-6 and Comparative Examples 1-3 of the present invention.

[0046] Treatment method: oral administration, once a day, 7 days as a course of treatment, 8 courses in total.

[0047] The efficacy criteria are as follows: Cure: Herpes zoster and skin lesions disappear; Significant effect: Shingles basically disappeared, with slight pain and scattered scabs on the skin; Effective: There is a small amount of herpes and local pain; Ineffective: No improvement in herpes zoster and skin lesions.

[0048] There were 160 patients, including 78 males and 82 females, aged between 30 and 80 years old, who were divided into 8 groups, with 20 patients in each group. The clinical experimental observation results are shown in Table 1.

[0049] Table 1 - Results of clinical trials on the treatment of herpes zoster project Number of people cure Cure rate% Significant effect efficient invalid Total effective rate% Example 1 20 8 40% 5 6 1 95% Example 2 20 9 45% 5 5 1 95% Example 3 20 11 55% 5 4 0 100% Example 4 20 12 60% 5 3 0 100% Example 5 20 14 70% 6 0 0 100% Example 6 20 9 45% 6 4 1 95% Comparative Example 1 20 4 20% 5 7 4 80% Comparative Example 2 20 5 25% 4 6 5 75% Comparative Example 3 20 6 30% 6 5 3 85% As can be seen from Table 1, the Chinese medicine compositions prepared in Examples 1-6 have a good therapeutic effect on herpes zoster, with a cure rate of more than 40% and an effective rate of more than 90%. In particular, in Example 5, by reasonably controlling the dosage of each Chinese medicine component, each Chinese medicine component exerts a synergistic effect, and the obtained pharmaceutical composition has the best therapeutic effect, with a cure rate of 70% and an effective rate of 100%. In Comparative Examples 1-3, the content of some Chinese medicine components is not within the scope defined by the present invention or a different preparation method is used, which will affect the therapeutic effect of the drug to a certain extent, significantly reduce the cure rate, and the effective rate is also significantly lower than that of the embodiment. This shows that the present invention adopts a specific combination of raw materials, dosage and appropriate preparation method to prepare a Chinese medicine composition, which has a good effect on the treatment of herpes zoster and is highly safe.

Claims

1. A Chinese medicine composition for treating herpes zoster, characterized in that: The raw material components include: 10-30 weight parts of raw astragalus, 5-15 weight parts of white ginseng, 10-30 weight parts of wolfberry, 5-15 weight parts of polygonatum, 20-40 weight parts of Ligustrum lucidum, 5-15 weight parts of plantago, 10-20 weight parts of dodder seed, 5-15 weight parts of moutan bark, 5-15 weight parts of magnolia bark, 5-10 weight parts of frankincense, 5-10 weight parts of myrrh, 5-15 weight parts of corydalis, and 5-15 weight parts of raw licorice.

2. The Chinese medicine composition for treating herpes zoster according to claim 1, characterized in that: The raw material components include: 15-25 weight parts of raw astragalus, 8-12 weight parts of white ginseng, 15-25 weight parts of wolfberry, 8-12 weight parts of polygonatum, 15-25 weight parts of ligustrum lucidum, 8-12 weight parts of plantago, 12-18 weight parts of dodder seed, 8-12 weight parts of moutan bark, 8-12 weight parts of magnolia bark, 6-8 weight parts of frankincense, 6-8 weight parts of myrrh, 8-12 weight parts of corydalis, and 8-12 weight parts of raw licorice.

3. The Chinese medicine composition for treating herpes zoster according to claim 1 or 2, characterized in that: The raw material components include: 20 parts by weight of raw astragalus, 10 parts by weight of white ginseng, 20 parts by weight of wolfberry, 10 parts by weight of polygonatum, 30 parts by weight of glossy privet, 10 parts by weight of plantain seeds, 15 parts by weight of dodder seeds, 10 parts by weight of moutan bark, 10 parts by weight of magnolia bark, 7 parts by weight of frankincense, 7 parts by weight of myrrh, 10 parts by weight of corydalis, and 10 parts by weight of raw licorice.

4. The method for preparing the Chinese medicine composition for treating herpes zoster according to any one of claims 1 to 3, characterized in that: The steps include: (1) Raw astragalus, white ginseng, wolfberry, polygonatum, glossy privet, plantago and dodder seeds are taken according to weight, and ultrafinely ground to obtain ultrafine powders of each Chinese medicine; (2) taking the remaining raw material components by weight, crushing them, and mixing them thoroughly to obtain a Chinese medicine mixed powder; (3) adding water to the mixed Chinese medicine powder obtained in step (2), performing water extraction to obtain a water extract; (4) filtering and concentrating the aqueous extract of step (3) to obtain a concentrate; (5) The concentrate of step (4) is dried and ultrafinely ground in sequence, and then the ultrafine powders of the Chinese medicinal materials of step (1) are added and mixed thoroughly to obtain the Chinese medicinal composition for treating herpes zoster.

5. The method for preparing the Chinese medicine composition for treating herpes zoster according to claim 4, characterized in that: In step (1), the particle size of each Chinese medicine ultrafine powder is 1000-1500 mesh.

6. The method for preparing the Chinese medicine composition for treating herpes zoster according to claim 4, characterized in that: In step (3), the mass ratio of the Chinese medicine mixed powder to the added water is 1:4-1:

8.

7. The method for preparing the Chinese medicine composition for treating herpes zoster according to claim 4, characterized in that: In step (3), the water extraction treatment time is 1-2 hours; In step (4), the concentration is concentrated under reduced pressure to a thick paste with a relative density of 1.30-1.35; In step (5), the drying temperature is 80-120°C.

8. The method for preparing the Chinese medicine composition for treating herpes zoster according to claim 4, characterized in that: In step (5), the particle size of the ultrafine powder obtained after ultrafine grinding is 1000-1500 mesh.

9. Use of the Chinese medicine composition according to any one of claims 1 to 3 or the Chinese medicine composition prepared by the method according to any one of claims 4 to 8 in preparing a medicament for treating herpes zoster.