Electronic air-oxygen mixer and method for detecting carbon dioxide clearance rate

Abstract

The embodiment of the invention provides an electronic air-oxygen mixer and a method for detecting the carbon dioxide clearance rate, and relates to the technical field of in-vitro life support. According to the embodiment of the invention, through the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor which are integrated in the electronic air-oxygen mixer, the volume flow of the mixed gas and the carbon dioxide concentration of the gas outlet of the membrane oxygenator can be monitored in real time; therefore, the electronic air-oxygen mixer can continuously calculate and update the carbon dioxide clearance rate in real time. Therefore, errors caused by regular sampling can be reduced, the accuracy and the reliability of carbon dioxide clearance rate data are improved, a doctor can quickly respond according to the carbon dioxide clearance rate data and timely discover the function decline or blockage condition of the membrane oxygenator, carbon dioxide retention in the body of a patient is avoided, and the safety of the patient is improved. Therefore, the safety of the patient is enhanced.

Description

Technical Field

[0001] The present application relates to the field of extracorporeal life support technology, and in particular to an electronic air-oxygen mixer and a method for detecting a carbon dioxide clearance rate. Background Art

[0002] In the extracorporeal life support technology, extracorporeal membrane oxygenation (ECMO) and extracorporeal carbon dioxide removal (ECO) are the most important technologies for the treatment of extracorporeal lung diseases. ) are two important treatment methods. These two treatment methods draw the patient's blood out of the body, oxygenate the blood and remove carbon dioxide through a membrane oxygenator, and then return the treated blood to the patient's body to maintain or assist the patient's vital functions. During the treatment process, carbon dioxide removal rate is an important indicator to evaluate the performance of membrane oxygenator.

[0003] At present, the method for detecting the carbon dioxide clearance rate of membrane oxygenators is usually blood gas analysis. This method requires regular collection of blood samples from the blood inlet and bleeding ports of the membrane oxygenator, and then using a blood gas analyzer to measure key indicators in these blood samples (such as carbon dioxide partial pressure, bicarbonate concentration, and total carbon dioxide, etc.), and inputting the above key indicators into the carbon dioxide solubility model to calculate the carbon dioxide clearance rate.

[0004] However, the above method can only collect and analyze blood samples periodically, and cannot perform real-time, continuous carbon dioxide clearance detection. This is not only prone to errors caused by periodic sampling, reducing the accuracy and reliability of carbon dioxide clearance data, but also makes it impossible for doctors to respond quickly based on carbon dioxide clearance data, limiting the ability of doctors to promptly detect the decline or blockage of membrane oxygenator function, which may lead to carbon dioxide accumulation in the patient's body and even aggravate the condition. Summary of the invention

[0005] Based on the above problems, the present application provides an electronic air-oxygen mixer and a method for detecting a carbon dioxide removal rate, which can calculate and update the carbon dioxide removal rate in real time and continuously.

[0006] The embodiments of the present application disclose the following technical solutions: In a first aspect, the present application discloses an electronic air-oxygen mixer, the electronic air-oxygen mixer comprising: A mixing chamber, an oxygen concentration flow sensor, a carbon dioxide gas concentration sensor and a main control module; wherein the mixing chamber is provided with an air inlet, an oxygen inlet and a mixed gas outlet; the oxygen concentration flow sensor is arranged on a gas flow path between the mixed gas outlet and the air inlet of a membrane oxygenator; the carbon dioxide gas concentration sensor is arranged at the air outlet of the membrane oxygenator; the main control module is communicatively connected with the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor; The mixing chamber is used to mix the medical compressed air input through the air inlet and the oxygen input through the oxygen inlet to obtain a mixed gas; and to input the mixed gas into the inlet of the membrane oxygenator through the mixed gas outlet via the oxygen concentration flow sensor; The oxygen concentration flow sensor is used to monitor the volume flow of the mixed gas in real time; The carbon dioxide gas concentration sensor is used to monitor the carbon dioxide concentration at the gas outlet of the membrane oxygenator in real time; The main control module is used to determine the carbon dioxide removal rate according to the volume flow rate of the mixed gas and the carbon dioxide concentration.

[0007] Optionally, the formula for determining the carbon dioxide removal rate according to the volume flow rate of the mixed gas and the carbon dioxide concentration is as follows:

[0008] in, is the carbon dioxide removal rate, is the volume flow rate of the mixed gas, is the carbon dioxide concentration.

[0009] Optionally, the electronic air-oxygen mixer further comprises a first regulating valve and a second regulating valve; wherein the first regulating valve is connected to the air inlet, and is used to regulate the flow rate of medical compressed air entering the mixing chamber; the second regulating valve is connected to the oxygen inlet, and is used to regulate the flow rate of oxygen entering the mixing chamber; The main control module is further configured to control the openings of the first regulating valve and the second regulating valve according to the carbon dioxide removal rate.

[0010] Optionally, the main control module is specifically configured to, when the carbon dioxide removal rate is lower than a first value, increase the opening of the second regulating valve, and / or decrease the opening of the first regulating valve; When the carbon dioxide removal rate is higher than a second value, the opening of the first regulating valve is increased, and / or the opening of the second regulating valve is decreased, wherein the second value is higher than the first value.

[0011] Optionally, the main control module is further configured to trigger an alarm indication when the carbon dioxide removal rate is higher than a third value, or when the carbon dioxide removal rate is lower than a fourth value, wherein the third value is higher than the fourth value.

[0012] Optionally, the electronic air-oxygen mixer is used to communicate with a display module; The main control module is also used to send the carbon dioxide removal rate, the volume flow rate of the mixed gas and the carbon dioxide concentration to the display module in real time, so that the display module displays at least one of the carbon dioxide removal rate, the volume flow rate of the mixed gas and the carbon dioxide concentration.

[0013] Optionally, the electronic air-oxygen mixer is used to communicate with an extracorporeal membrane oxygenation ECMO host or an extracorporeal carbon dioxide removal Host communication connection; The main control module is also used to provide real-time information to the ECMO host or the The host sends the carbon dioxide removal rate.

[0014] In a second aspect, the present application discloses a method for detecting a carbon dioxide removal rate, which is applied to an electronic air-oxygen mixer as described in the first aspect, and the method comprises: Acquire the gas flow of the mixed gas detected in real time by the oxygen concentration flow sensor, and the carbon dioxide concentration at the gas outlet of the membrane oxygenator detected in real time by the carbon dioxide gas concentration sensor; A carbon dioxide removal rate is determined based on the volume flow rate of the mixed gas and the carbon dioxide concentration.

[0015] Optionally, the formula for determining the carbon dioxide removal rate according to the volume flow rate of the mixed gas and the carbon dioxide concentration is as follows:

[0016] in, is the carbon dioxide removal rate, is the volume flow rate of the mixed gas, is the carbon dioxide concentration.

[0017] Optionally, the electronic air-oxygen mixer is used to communicate with an extracorporeal membrane oxygenation ECMO host or an extracorporeal carbon dioxide removal Host communication connection; The method further comprises: providing real-time information to the ECMO host or the The host sends the carbon dioxide removal rate.

[0018] Compared with the prior art, this application has the following beneficial effects: The embodiment of the present application provides an electronic air-oxygen mixer and a method for detecting a carbon dioxide removal rate. The electronic air-oxygen mixer includes: a mixing chamber, an oxygen concentration flow sensor, a carbon dioxide gas concentration sensor and a main control module; wherein an air inlet, an oxygen inlet and a mixed gas outlet are arranged on the mixing chamber; the oxygen concentration flow sensor is arranged on a gas flow path between the mixed gas outlet and the inlet of a membrane oxygenator; the carbon dioxide gas concentration sensor is arranged at the outlet of the membrane oxygenator; the main control module is communicatively connected with the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor; the mixing chamber is used to mix medical compressed air input through the air inlet and oxygen input through the oxygen inlet to obtain a mixed gas; the mixed gas is input into the inlet of the membrane oxygenator through the mixed gas outlet via the oxygen concentration flow sensor; the oxygen concentration flow sensor is used to monitor the volume flow of the mixed gas in real time; the carbon dioxide gas concentration sensor is used to monitor the carbon dioxide concentration at the outlet of the membrane oxygenator in real time; the main control module is used to determine the carbon dioxide removal rate according to the volume flow and carbon dioxide concentration of the mixed gas. Therefore, the embodiment of the present application can monitor the volume flow of the mixed gas and the carbon dioxide concentration at the outlet of the membrane oxygenator in real time through the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor integrated in the electronic air-oxygen mixer, so that the electronic air-oxygen mixer can calculate and update the carbon dioxide clearance rate in real time and continuously. This not only helps to reduce the errors caused by periodic sampling, improves the accuracy and reliability of carbon dioxide clearance rate data, but also enables doctors to respond quickly according to the carbon dioxide clearance rate data, timely discover the function decline or blockage of the membrane oxygenator, avoid carbon dioxide retention in the patient's body, and thus enhance the safety of the patient. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0020] Figure 1 A schematic diagram of an electronic air-oxygen mixer provided in an embodiment of the present application; Figure 2 A schematic diagram of another electronic air-oxygen mixer provided in an embodiment of the present application; Figure 3 A schematic diagram of a data transmission system provided in an embodiment of the present application; Figure 4 A flow chart of a method for detecting a carbon dioxide removal rate provided in an embodiment of the present application; Figure 5 A schematic diagram of a computer-readable medium provided for an embodiment of the present application. DETAILED DESCRIPTION

[0021] First, the technical terms involved in the embodiments of the present application are explained: Extracorporeal Membrane Oxygenation (ECMO) is an important extracorporeal life support technology, which is mainly used to provide continuous extracorporeal respiration and circulation for patients with severe cardiopulmonary failure. The patient's blood is drawn out of the body, oxygenated and carbon dioxide removed through a membrane oxygenator, and then returned to the patient's body, thereby maintaining the patient's vital functions.

[0022] Extracorporeal CO 2 Removal, ) is a treatment method that draws the patient's blood out of the body through an extracorporeal circulation device and removes carbon dioxide in the blood through a membrane oxygenator. It can effectively remove carbon dioxide generated by the body's metabolism to reduce the patient's ventilation needs and ventilator support level.

[0023] As described above, the current method for detecting the carbon dioxide clearance rate of membrane oxygenators is usually blood gas analysis. This method requires regular collection of blood samples from the blood inlet and bleeding ports of the membrane oxygenator, and then using a blood gas analyzer to measure key indicators in these blood samples (such as carbon dioxide partial pressure, bicarbonate concentration, and total carbon dioxide, etc.), and inputting the above key indicators into the carbon dioxide solubility model to calculate the carbon dioxide clearance rate.

[0024] However, the above method can only collect and analyze blood samples periodically, and cannot perform real-time, continuous carbon dioxide clearance detection. This is not only prone to errors caused by periodic sampling, reducing the accuracy and reliability of carbon dioxide clearance data, but also makes it impossible for doctors to respond quickly based on carbon dioxide clearance data, limiting the ability of doctors to promptly detect the decline or blockage of membrane oxygenator function, which may lead to carbon dioxide accumulation in the patient's body and even aggravate the condition.

[0025] After research, the inventor proposed an electronic air-oxygen mixer and a method for detecting carbon dioxide clearance. The embodiment of the present application can monitor the volume flow of the mixed gas and the carbon dioxide concentration at the outlet of the membrane oxygenator in real time through the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor integrated in the electronic air-oxygen mixer, so that the electronic air-oxygen mixer can calculate and update the carbon dioxide clearance in real time and continuously. This not only helps to reduce the errors caused by periodic sampling and improve the accuracy and reliability of carbon dioxide clearance data, but also enables doctors to respond quickly according to the carbon dioxide clearance data, timely discover the function decline or blockage of the membrane oxygenator, avoid carbon dioxide retention in the patient's body, and thus enhance the safety of the patient.

[0026] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0027] Embodiment 1

[0028] See also Figure 1 , which is a schematic diagram of an electronic air-oxygen mixer provided in an embodiment of the present application. The electronic air-oxygen mixer includes a mixing chamber, an oxygen concentration flow sensor, a carbon dioxide gas concentration sensor and a main control module (not shown in the figure).

[0029] The mixing chamber is provided with an air inlet, an oxygen inlet and a mixed gas outlet, wherein the air inlet and the oxygen inlet are usually arranged at the upper part of the mixing chamber, and the mixed gas outlet is usually arranged at the side or bottom of the mixing chamber. The mixing chamber is used to fully mix the medical compressed air input through the air inlet and the oxygen input through the oxygen inlet in the mixing chamber to obtain a mixed gas with a certain oxygen concentration. Subsequently, the mixed gas is input into the air inlet of the membrane oxygenator through the mixed gas outlet via the oxygen concentration flow sensor.

[0030] The oxygen concentration flow sensor is installed on the gas flow path between the mixed gas outlet and the membrane oxygenator inlet. The oxygen concentration flow sensor is used to monitor the volume flow of the mixed gas in real time. By accurately measuring the volume flow, the oxygen concentration flow sensor can provide important data support for subsequent gas mixing control and monitoring.

[0031] The carbon dioxide gas concentration sensor is arranged at the gas outlet of the membrane oxygenator. The carbon dioxide gas concentration sensor is used to monitor the carbon dioxide concentration of the oxygenated gas at the gas outlet of the membrane oxygenator in real time. Specifically, the carbon dioxide gas concentration sensor can use the infrared absorption measurement method to measure the real-time carbon dioxide concentration using the characteristic absorption peak of the 4.26μm infrared spectrum of carbon dioxide molecules.

[0032] The main control module is connected to the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor. The main control module is used to determine the carbon dioxide removal rate according to the volume flow rate and carbon dioxide concentration of the mixed gas. Specifically, the carbon dioxide removal rate can be determined according to the volume flow rate and carbon dioxide concentration of the mixed gas by the following formula (1): (1) in, is the carbon dioxide removal rate (mL / min), is the volume flow rate of the mixed gas (mL / min), is the carbon dioxide concentration (%).

[0033] It can be understood that the overall workflow of the electronic air-oxygen mixer and the membrane oxygenator is as follows: the oxygen inlet and the air inlet of the electronic air-oxygen mixer are used to input oxygen and medical compressed air respectively. After the oxygen and medical compressed air are mixed, the mixed gas flows through the oxygen concentration flow sensor, and then is transported to the membrane oxygenator inlet through the outlet of the electronic air-oxygen mixer, and enters the gas chamber of the membrane oxygenator. At this time, blood flows through the blood chamber on the other side of the gas chamber of the membrane oxygenator separated by the oxygenation membrane. Through the semipermeability of the oxygenation membrane, oxygen diffuses from the gas side to the blood side, and carbon dioxide diffuses from the blood side to the gas side, thereby achieving blood oxygenation and carbon dioxide removal. The carbon dioxide gas on the gas side diffused from the blood side flows out of the outlet of the membrane oxygenator together with the remaining mixed gas in the gas chamber. There is a carbon dioxide gas concentration sensor at the outlet of the membrane oxygenator to measure the carbon dioxide gas of the mixed gas flowing out of the outlet of the membrane oxygenator in real time. According to the volume flow rate and carbon dioxide concentration of the mixed gas, the carbon dioxide removal rate can be determined.

[0034] In summary, the present application discloses an electronic air-oxygen mixer. The embodiment of the present application can monitor the volume flow of the mixed gas and the carbon dioxide concentration at the outlet of the membrane oxygenator in real time through the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor integrated in the electronic air-oxygen mixer, so that the electronic air-oxygen mixer can calculate and update the carbon dioxide clearance rate in real time and continuously. This not only helps to reduce the errors caused by periodic sampling and improve the accuracy and reliability of carbon dioxide clearance rate data, but also enables doctors to respond quickly according to the patient's carbon dioxide clearance rate data, timely discover the function decline or blockage of the membrane oxygenator, avoid carbon dioxide retention in the patient's body, and thus enhance the safety of the patient.

[0035] Embodiment 2 See also Figure 2 , which is a schematic diagram of another electronic air-oxygen mixer provided in an embodiment of the present application. Figure 2 The electronic air-oxygen mixer shown includes a mixing chamber, an oxygen concentration flow sensor, a carbon dioxide gas concentration sensor and a main control module, which are similar to the first embodiment and will not be described in detail here.

[0036] In a specific implementation, Figure 2 The electronic air-oxygen mixer shown also includes a first regulating valve and a second regulating valve. The first regulating valve is connected to the air inlet for regulating the flow of medical compressed air entering the mixing chamber. The second regulating valve is connected to the oxygen inlet for regulating the flow of oxygen entering the mixing chamber. It is understandable that medical compressed air needs to be strictly filtered and dried to ensure its purity and safety.

[0037] Then, the main control module is also used to dynamically adjust the opening of the first regulating valve and the second regulating valve according to the carbon dioxide removal rate to control the oxygen concentration and flow rate of the mixed gas.

[0038] Specifically, when the carbon dioxide clearance rate is low (for example, the carbon dioxide clearance rate is lower than the first value), this usually means that the patient may need a higher oxygen concentration to promote the discharge of carbon dioxide, then the main control module will increase the opening of the second regulating valve to increase the oxygen flow rate, and / or reduce the opening of the first regulating valve to reduce the air flow rate, thereby reducing the inactive gas components such as nitrogen in the mixed gas, and indirectly increasing the oxygen concentration. When the carbon dioxide clearance rate is high (for example, the carbon dioxide clearance rate is higher than the second value), this means that the current oxygen concentration is too high and needs to be appropriately reduced to avoid potential oxygen poisoning risks, then the main control module will reduce the opening of the second regulating valve to reduce the oxygen flow rate, and / or increase the opening of the first regulating valve to increase the air flow rate, thereby increasing nitrogen and other components in the mixed gas, and indirectly reducing the oxygen concentration.

[0039] Therefore, through this dynamic adjustment mechanism, the electronic air-oxygen mixer can automatically adjust the ratio of oxygen and air in the mixed gas according to the patient's real-time breathing condition to ensure the safety and effectiveness of treatment. This automated process not only reduces the need for manual intervention by medical staff, reduces the difficulty of operation and the risk of error, but also provides more accurate and personalized treatment support to meet the specific needs of different patients.

[0040] In some specific implementations, the main control module is further used to trigger an alarm indication when the carbon dioxide removal rate is higher than a third value or lower than a fourth value (i.e., the carbon dioxide removal rate exceeds a preset safety range) to alert operators or medical personnel of possible operational abnormalities of the current device. The third value is a preset maximum value, the fourth value is a preset minimum value, and the third value is higher than the fourth value.

[0041] Specifically, when the carbon dioxide removal rate is higher than the third value, this usually means that the oxygen concentration in the mixed gas may be too high, resulting in excessive removal of carbon dioxide. Excessive carbon dioxide removal may lead to respiratory alkalosis, an acid-base balance disorder caused by a decrease in the bicarbonate concentration in the blood. To avoid this risk, the main control module will trigger an alarm indication to remind the operator or medical staff to immediately check and adjust the mixture ratio of oxygen and air to ensure that the oxygen concentration is within a safe range.

[0042] On the contrary, when the carbon dioxide removal rate is lower than the fourth value, it usually means that the oxygen concentration in the mixed gas is too low or the gas flow is insufficient, resulting in low carbon dioxide removal efficiency. In this case, the patient may be at risk of respiratory acidosis, that is, the bicarbonate concentration in the blood is too high, causing acid-base imbalance. In order to ensure the safety of the patient, the main control module will also trigger an alarm indication to remind the operator or medical staff to take prompt action to increase the oxygen flow or adjust the mixing ratio to increase the carbon dioxide removal rate and avoid the occurrence of acidosis.

[0043] The triggering of the alarm indication is usually achieved through sound, light or other forms of alarm signals to ensure that the operator or medical staff can quickly notice the current operating status of the equipment. These alarm signals may include but are not limited to: sound alarm, light signal alarm, remote alarm, etc.

[0044] Therefore, the introduction of the alarm indication function not only improves the safety and reliability of the electronic air-oxygen mixer, but also enhances the operator or medical staff's ability to monitor the operating status of the equipment. By responding to the alarm indication in a timely manner, potential medical risks can be quickly discovered and corrected to ensure that patients receive safe and effective treatment. At the same time, this also reduces the risk of medical accidents caused by equipment failure or operating errors, and improves the overall quality of medical services.

[0045] In some specific implementations, the electronic air-oxygen mixer can be powered by a DC12V power supply and connected to the display module through communication protocols such as the Controller Area Network (CAN). Among them, the CAN bus is a multi-host serial communication bus with the characteristics of high communication rate, strong anti-interference ability, and long transmission distance. In medical equipment, the CAN bus is often used to connect various functional modules to achieve high-speed and reliable data transmission.

[0046] Then, the main control module is also used to send the carbon dioxide removal rate, the volume flow rate of the mixed gas and the carbon dioxide concentration to the display module in real time, so that the display module can display at least one of the carbon dioxide removal rate, the volume flow rate of the mixed gas and the carbon dioxide concentration through an intuitive interface. These interfaces may include digital display screens, graphical interfaces, etc. Users (such as patients, family members) and doctors can understand the treatment effect by viewing these data, so as to make more informed decisions.

[0047] In summary, the present application discloses an electronic air-oxygen mixer. The embodiment of the present application can monitor the volume flow of the mixed gas and the carbon dioxide concentration at the outlet of the membrane oxygenator in real time through the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor integrated in the electronic air-oxygen mixer, so that the electronic air-oxygen mixer can calculate and update the carbon dioxide clearance rate in real time and continuously. This not only helps to reduce the errors caused by periodic sampling and improve the accuracy and reliability of carbon dioxide clearance rate data, but also enables doctors to respond quickly according to the patient's carbon dioxide clearance rate data, timely discover the function decline or blockage of the membrane oxygenator, avoid carbon dioxide retention in the patient's body, and thus enhance the safety of the patient.

[0048] Embodiment 3 See also Figure 3 , which is a schematic diagram of a data transmission system provided in an embodiment of the present application. Figure 3 As shown, the data transmission system includes the electronic air-oxygen mixer disclosed in the above-mentioned embodiment 1 or embodiment 2, and an ECMO host or Host. Among them, ECMO host or The host is used to support or replace the patient's lung function, especially in the case of severe respiratory failure or heart failure. They exchange gases through the membrane oxygenator to provide the patient with the necessary oxygen and nutrients while removing carbon dioxide and other wastes from the body. In addition, the electronic air-oxygen mixer communicates with the ECMO host or The host establishes a communication connection.

[0049] Then, the main control module is also used to send real-time The host sends the carbon dioxide clearance rate. By receiving the carbon dioxide clearance data sent by the electronic air-oxygen mixer, the host can more accurately adjust the treatment parameters, such as gas flow, oxygen concentration, etc. This precise adjustment helps to optimize the treatment effect, reduce the occurrence of complications, and improve the patient's survival rate and quality of life.

[0050] In summary, the embodiment of the present application provides a data transmission system, which integrates an electronic air-oxygen mixer and an ECMO host or The host can exchange data through efficient communication protocols, greatly improving the accuracy and safety of treatment. It not only helps doctors to more accurately evaluate the treatment progress and response of patients, but also provides strong support for the precise adjustment of treatment parameters. The application of this technical solution will help improve the effect of extracorporeal membrane oxygenation or extracorporeal carbon dioxide removal therapy, and bring better treatment effects and quality of life to patients.

[0051] Embodiment 4 See also Figure 4 , which is a flow chart of a method for detecting carbon dioxide removal rate provided in an embodiment of the present application. The method is applied to the electronic air-oxygen mixer disclosed in the first or second embodiment, and the method includes: S401: Acquire the gas flow rate of the mixed gas detected in real time by the oxygen concentration flow sensor, and the carbon dioxide concentration at the gas outlet of the membrane oxygenator detected in real time by the carbon dioxide gas concentration sensor.

[0052] S402: Determine a carbon dioxide removal rate based on the volume flow rate of the mixed gas and the carbon dioxide concentration.

[0053] In some specific implementations, the carbon dioxide removal rate can be determined according to the volume flow rate of the mixed gas and the carbon dioxide concentration by the following formula (2): (2) in, is the carbon dioxide removal rate, is the volume flow rate of the mixed gas, is the carbon dioxide concentration.

[0054] In some specific implementations, the method further includes: triggering an alarm indication when the carbon dioxide removal rate is higher than a third value, or when the carbon dioxide removal rate is lower than a fourth value, wherein the third value is higher than the fourth value.

[0055] In some specific implementations, the electronic air-oxygen mixer is used to communicate with an extracorporeal membrane oxygenation (ECMO) host or an extracorporeal carbon dioxide removal system. Host communication connection; The method also includes: sending a real-time The host sends the CO2 removal rate.

[0056] In summary, the present application discloses a method for detecting carbon dioxide clearance rate. The embodiment of the present application can monitor the volume flow rate of the mixed gas and the carbon dioxide concentration at the outlet of the membrane oxygenator in real time through the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor integrated in the electronic air-oxygen mixer, so that the electronic air-oxygen mixer can calculate and update the carbon dioxide clearance rate in real time and continuously. This not only helps to reduce the errors caused by periodic sampling, improves the accuracy and reliability of carbon dioxide clearance rate data, but also enables doctors to respond quickly according to the patient's carbon dioxide clearance rate data, timely discover the function decline or blockage of the membrane oxygenator, avoid carbon dioxide retention in the patient's body, and thus enhance the safety of the patient.

[0057] See also Figure 5 , which is a schematic diagram of a computer-readable medium provided in an embodiment of the present application. The computer-readable medium 500 stores a computer program 511, which implements the above-mentioned Figure 4 The steps of the method for detecting the carbon dioxide removal rate.

[0058] It should be noted that in the context of the present application, a machine-readable medium may be a tangible medium that may contain or store a program for use by or in conjunction with an instruction execution system, device or equipment. A machine-readable medium may be a machine-readable signal medium or a machine-readable storage medium. A machine-readable medium may include, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, device or equipment, or any suitable combination of the foregoing. A more specific example of a machine-readable storage medium may include an electrical connection based on one or more lines, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.

[0059] It should be noted that the machine-readable medium mentioned above in the present application may be a computer-readable signal medium or a computer-readable storage medium or any combination of the above two. The computer-readable storage medium may be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device or device, or any combination of the above. More specific examples of computer-readable storage media may include, but are not limited to: an electrical connection with one or more wires, a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the above. In the present application, a computer-readable storage medium may be any tangible medium containing or storing a program that can be used by or in combination with an instruction execution system, device or device. In the present application, a computer-readable signal medium may include a data signal propagated in a baseband or as part of a carrier wave, which carries a computer-readable program code. This propagated data signal may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the above. The computer readable signal medium may also be any computer readable medium other than a computer readable storage medium, which may send, propagate or transmit a program for use by or in conjunction with an instruction execution system, apparatus or device. The program code contained on the computer readable medium may be transmitted using any suitable medium, including but not limited to: wires, optical cables, RF (radio frequency), etc., or any suitable combination of the above.

[0060] The computer-readable medium may be included in the electronic device, or may exist independently without being incorporated into the electronic device.

[0061] Although the subject matter has been described in language specific to structural features and / or methodological logical actions, it should be understood that the subject matter defined in the appended claims is not necessarily limited to the specific features or actions described above. On the contrary, the specific features and actions described above are merely example forms of implementing the claims.

[0062] Although several specific implementation details are included in the above discussion, these should not be interpreted as limiting the scope of the present application. Certain features described in the context of a separate embodiment can also be implemented in a single embodiment in combination. On the contrary, the various features described in the context of a single embodiment can also be implemented in multiple embodiments individually or in any suitable sub-combination.

[0063] The above description is only a preferred embodiment of the present application and an explanation of the technical principles used. Those skilled in the art should understand that the scope of disclosure involved in the present application is not limited to the technical solution formed by a specific combination of the above technical features, but should also cover other technical solutions formed by any combination of the above technical features or their equivalent features without departing from the above disclosed concept. For example, the above features are replaced with the technical features with similar functions disclosed in this application (but not limited to) by each other to form a technical solution.

Claims

1. An electronic air-oxygen mixer, characterized in that: The electronic air-oxygen mixer comprises: a mixing chamber, an oxygen concentration flow sensor, a carbon dioxide gas concentration sensor and a main control module; The mixing chamber is provided with an air inlet, an oxygen inlet and a mixed gas outlet; the oxygen concentration flow sensor is provided on the gas flow path between the mixed gas outlet and the air inlet of the membrane oxygenator; the carbon dioxide gas concentration sensor is provided at the outlet of the membrane oxygenator; the main control module is communicatively connected with the oxygen concentration flow sensor and the carbon dioxide gas concentration sensor; The mixing chamber is used to mix the medical compressed air input through the air inlet and the oxygen input through the oxygen inlet to obtain a mixed gas; and to input the mixed gas into the inlet of the membrane oxygenator through the mixed gas outlet via the oxygen concentration flow sensor; The oxygen concentration flow sensor is used to monitor the volume flow of the mixed gas in real time; The carbon dioxide gas concentration sensor is used to monitor the carbon dioxide concentration at the gas outlet of the membrane oxygenator in real time; The main control module is used to determine the carbon dioxide removal rate according to the volume flow rate of the mixed gas and the carbon dioxide concentration.

2. The electronic air-oxygen mixer according to claim 1, characterized in that: The formula for determining the carbon dioxide removal rate based on the volume flow rate of the mixed gas and the carbon dioxide concentration is as follows: ； in, is the carbon dioxide removal rate, is the volume flow rate of the mixed gas, is the carbon dioxide concentration.

3. The electronic air-oxygen mixer according to claim 1, characterized in that: The electronic air-oxygen mixer also includes a first regulating valve and a second regulating valve; wherein the first regulating valve is connected to the air inlet, and the first regulating valve is used to regulate the flow rate of medical compressed air entering the mixing chamber; the second regulating valve is connected to the oxygen inlet, and the second regulating valve is used to regulate the flow rate of oxygen entering the mixing chamber; The main control module is further configured to control the openings of the first regulating valve and the second regulating valve according to the carbon dioxide removal rate.

4. The electronic air-oxygen mixer according to claim 3, characterized in that: The main control module is specifically configured to, when the carbon dioxide removal rate is lower than a first value, increase the opening of the second regulating valve, and / or reduce the opening of the first regulating valve; When the carbon dioxide removal rate is higher than a second value, the opening of the first regulating valve is increased, and / or the opening of the second regulating valve is decreased, wherein the second value is higher than the first value.

5. The electronic air-oxygen mixer according to claim 1, characterized in that: The main control module is further configured to trigger an alarm indication when the carbon dioxide removal rate is higher than a third value, or when the carbon dioxide removal rate is lower than a fourth value, wherein the third value is higher than the fourth value.

6. The electronic air-oxygen mixer according to claim 1, characterized in that: The electronic air-oxygen mixer is used to communicate with the display module; The main control module is also used to send the carbon dioxide removal rate, the volume flow rate of the mixed gas and the carbon dioxide concentration to the display module in real time, so that the display module displays at least one of the carbon dioxide removal rate, the volume flow rate of the mixed gas and the carbon dioxide concentration.

7. The electronic air-oxygen mixer according to any one of claims 1 to 6, characterized in that: The electronic air-oxygen mixer is used for extracorporeal membrane oxygenation ECMO host or extracorporeal carbon dioxide removal Host communication connection; The main control module is also used to provide real-time information to the ECMO host or the The host sends the carbon dioxide removal rate.

8. A method for detecting carbon dioxide removal rate, characterized in that: Applied to an electronic air-oxygen mixer as claimed in any one of claims 1 to 7, the method comprising: Acquire the gas flow of the mixed gas detected in real time by the oxygen concentration flow sensor, and the carbon dioxide concentration at the gas outlet of the membrane oxygenator detected in real time by the carbon dioxide gas concentration sensor; A carbon dioxide removal rate is determined based on the volume flow rate of the mixed gas and the carbon dioxide concentration.

9. The method according to claim 8, characterized in that The formula for determining the carbon dioxide removal rate based on the volume flow rate of the mixed gas and the carbon dioxide concentration is as follows: ； in, is the carbon dioxide removal rate, is the volume flow rate of the mixed gas, is the carbon dioxide concentration.

10. The method according to claim 8 or 9, characterized in that: The electronic air-oxygen mixer is used for extracorporeal membrane oxygenation ECMO host or extracorporeal carbon dioxide removal Host communication connection; The method further comprises: providing real-time information to the ECMO host or the The host sends the carbon dioxide removal rate.

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