Composition for relieving acne symptoms and fading acne marks as well as preparation method and application of composition

Abstract

The invention discloses a composition for relieving acne symptoms and fading acne marks as well as a preparation method and application of the composition, and belongs to the field of fine chemical engineering. The composition is prepared from the following components in parts by weight: 1 to 20 parts of quaternary ammonium salt-73, 1 to 30 parts of inonotus obliquus extract and 10 to 95 parts of glycyrrhiza inflate extract. The composition can relieve red, swollen and swelling pain when acnes occur, condition skin flora, relieve inflammation, fade pigmentation caused by inflammation and promote rapid healing of the acnes. The components of the composition can effectively cooperate, and the composition is mild and non-irritant and has excellent effects of relieving acne symptoms and fading acne marks.

Description

Technical Field

[0001] The present invention relates to a composition for alleviating acne symptoms and fading acne marks, specifically a composition for alleviating acne symptoms and fading acne marks, its preparation method and application, belonging to the field of fine chemicals. Background Art

[0002] Acne is a chronic inflammatory skin disease of the hair follicle sebaceous gland unit, and its clinical manifestations are characterized by polymorphic skin lesions such as comedones, papules, pustules, and nodules that commonly occur on the face. The occurrence of acne is mainly closely related to factors such as excessive sebum secretion, blockage of the hair follicle sebaceous gland duct, bacterial infection, and inflammatory reactions. Clinically, glucocorticoid drugs, antibacterial drugs, retinoid drugs, or traditional Chinese medicines are often given orally or topically, but long-term drug treatment will produce drug resistance and more adverse reactions. In cosmetics, oil-control ingredients or acid ingredients are often used for application, which may cause damage to the skin barrier and is extremely likely to relapse again. Comedone symptoms in the moderate to severe inflammatory stage will produce redness, swelling, pain, and a burning sensation, and pigmentation is likely to occur after the inflammation subsides, greatly affecting the quality of life of patients. However, the industry currently pays less attention to the discomfort during the inflammatory period and the post-inflammatory skin pigmentation problem.

[0003] Currently, the research on fading acne marks mainly uses whitening ingredients to achieve the effect of fading pigments. For example, Chinese Patent CN116831968A discloses a traditional Chinese medicine facial mask for improving post-acne inflammatory pigmentation and its preparation method. The traditional Chinese medicine facial mask includes raw materials: white chrysanthemum, rhubarb, nacre, Chinese honey locust, talc powder, notoginseng powder, polygonum cuspidatum, white muscardine silkworm, angelica dahurica, motherwort, campsis grandiflora, white morning glory, bletilla striata, salvia miltiorrhiza, safflower, and pearl powder, which has the effects of cooling blood and promoting blood circulation, clearing heat and detoxifying, expelling wind and drying dampness, and whitening and controlling oil. There are various whitening ingredients in the composition, which have an obvious improvement effect on post-facial acne inflammatory melanin pigmentation, but have no alleviating effect on the discomfort during the inflammatory process and do not involve the repair of damaged skin.

[0004] The technical problem to be solved by the present invention is that the existing acne-removing products on the market only simply condition the skin by controlling oil, inhibiting bacteria, or dredging the sebaceous gland duct, and cannot soothe the redness, heat, swelling, and pain caused by inflammatory acne, and do not involve the pigmentation caused by inflammation or the damage of the skin barrier. At the same time, the use of traditional antibacterial ingredients will also kill all bacteria on the skin without discrimination, which will cause the imbalance of the skin microecology and is instead prone to cause more problems. Summary of the Invention

[0005] To overcome the drawbacks and deficiencies of the prior art, the primary object of the present invention is to provide a composition for alleviating acne symptoms and fading acne marks, which can relieve the redness, swelling, pain during acne occurrence, regulate the skin flora, relieve inflammation and fade the pigmentation caused by inflammation, and promote the rapid healing of acne. The composition of the present invention can effectively cooperate, is mild and non-irritating, and has excellent effects in alleviating acne symptoms and fading acne marks.

[0006] To achieve the above object of the invention, the following technical solutions are adopted:

[0007] The composition for alleviating acne symptoms and fading acne marks is made of the following components in parts by weight: 1-20 parts of Quaternium-73, 1-30 parts of Inonotus obliquus extract, and 10-95 parts of Glycyrrhiza inflata extract.

[0008] To achieve the object of the present invention, the following technical solutions are adopted:

[0009] Quaternium-73 is purchased from LABORATOIRES SETHIC INNOVATIONS, Inonotus obliquus extract is purchased from BASF (China) Co., Ltd.; Glycyrrhiza inflata extract is purchased from Gansu Fanzhi Pharmaceutical Co., Ltd.

[0010] Preferably, a composition for alleviating acne symptoms and fading acne marks is characterized in that it contains 5-10 parts of Quaternium-73, 1-10 parts of Inonotus obliquus extract, and 10-90 parts of Glycyrrhiza inflata extract.

[0011] Preferably, a composition for alleviating acne symptoms and fading acne marks is characterized in that it contains 1-5 parts of Quaternium-73, 10-20 parts of Inonotus obliquus extract, and 10-80 parts of Glycyrrhiza inflata extract.

[0012] Preferably, a composition for alleviating acne symptoms and fading acne marks is characterized in that it contains 1-5 parts of Quaternium-73, 1-10 parts of Inonotus obliquus extract, and 20-95 parts of Glycyrrhiza inflata extract.

[0013] The second object of the present invention is to provide a preparation method of a composition for alleviating acne symptoms and fading acne marks, comprising the following steps: Among them, in order to improve the stability of the composition, the present invention additionally uses an auxiliary solvent polyol, such as at least one of glycerol, propylene glycol, dipropylene glycol, and ethoxydiglycol.

[0014] 1) Dissolve Quaternium-73 in polyol and heat to 80-85 °C until completely dissolved.

[0015] 2) After cooling to below 40 °C, add Glycyrrhiza inflata extract and Inonotus obliquus extract, and stir until dissolved evenly to obtain the composition.

[0016] The third aspect of the present invention provides the application of the composition described in the present invention in anti-acne cosmetics.

[0017] Preferably, the addition amount of the composition for treating acne is 0.001-1 wt%. More preferably, the addition amount of the oil-control and acne-treating composition is 0.05-0.2 wt%.

[0018] Preferably, the dosage form of the cosmetic includes one of cream, lotion, aqueous solution, gel, facial mask or cleansing product.

[0019] The present invention has the following advantages and effects compared with the prior art:

[0020] In the composition of the present invention, quaternary ammonium salt-73 has extremely strong antibacterial activity, can rapidly and durably reduce the number of pathogenic bacteria such as Propionibacterium acnes and Staphylococcus aureus, and can also inhibit the formation of melanin; the extract of Inonotus obliquus helps to protect and reinforce leaky blood vessels, protect the microvascular network from inflammatory damage, can also reduce the release of pro-inflammatory mediators, and enhance the repair of the skin barrier; the total flavonoids in the extract of Glycyrrhiza inflata can exert a multi-target anti-inflammatory effect, and the core component liquiritigenin in it can also block the voltage-gated sodium channels of sensory neurons. Glycyrrhiza inflata also has the effects of whitening and lightening spots.

[0021] The present invention comprehensively considers the links of acne occurrence and the pain points of consumers when and after acne occurs, and reasonably combines three components in a synergistic manner. It can not only relieve the redness, swelling and pain during acne occurrence, but also kill harmful bacteria and balance the skin microecology, and can further reduce inflammation and fade the acne marks caused by inflammation, and promote the healing of damaged wounds. The composition of the present invention can effectively cooperate in a mild and non-irritating manner, and has excellent effects of relieving acne symptoms and fading acne marks. Specific Embodiments

[0022] The following further describes the present invention in detail with reference to embodiments, but the embodiments of the present invention are not limited thereto.

[0023] The test methods without specific experimental conditions noted in the following examples are generally in accordance with conventional experimental conditions or the experimental conditions recommended by the manufacturer.

[0024] Example 1 A composition (Ⅰ) for relieving acne symptoms and fading acne marks

[0025] Preferably, a composition (Ⅰ) for relieving acne symptoms and fading acne marks, characterized in that it contains 5 parts of quaternary ammonium salt-73, 5 parts of the extract of Inonotus obliquus, and 90 parts of the extract of Glycyrrhiza inflata.

[0026] The preparation method is as follows:

[0027] 1) Dissolve quaternary ammonium salt - 73 in the auxiliary solvent ethoxydiglycol, and heat to 80 - 85 °C until completely dissolved.

[0028] 2) Cool down to below 40 °C, add the Inonotus obliquus extract and Glycyrrhiza inflata extract into 1), and stir until evenly dissolved to obtain the said composition.

[0029] Example 2 A composition (Ⅱ) for relieving acne symptoms and fading acne marks

[0030] Preferably, a composition (Ⅱ) for relieving acne symptoms and fading acne marks, characterized in that it contains 4 parts of quaternary ammonium salt - 73, 16 parts of Inonotus obliquus extract, and 80 parts of Glycyrrhiza inflata extract.

[0031] The preparation process is the same as that of Example 1.

[0032] Example 3 A composition (Ⅲ) for relieving acne symptoms and fading acne marks

[0033] Preferably, a composition (Ⅲ) for relieving acne symptoms and fading acne marks, characterized in that it contains 2.5 parts of quaternary ammonium salt - 73, 2.5 parts of Inonotus obliquus extract, and 95 parts of Glycyrrhiza inflata extract.

[0034] The preparation process is the same as that of Example 1.

[0035] Comparative Example 1

[0036] Compared with Example 1, replace quaternary ammonium salt - 73 with ethoxydiglycol, and keep the proportions of other components.

[0037] Comparative Example 2

[0038] Compared with Example 1, replace the Inonotus obliquus extract with ethoxydiglycol, and keep the proportions of other components.

[0039] Comparative Example 3

[0040] Compared with Example 1, replace the Glycyrrhiza inflata extract with ethoxydiglycol, and keep the proportions of other components.

[0041] Comparative Example 4

[0042] Compared with Example 1, replace quaternary ammonium salt - 73 and the Inonotus obliquus extract with ethoxydiglycol, and keep the proportion of the Glycyrrhiza inflata extract.

[0043] Comparative Example 5

[0044] Compared with Example 1, replace quaternary ammonium salt - 73 and the Glycyrrhiza inflata extract with ethoxydiglycol, and keep the proportion of the Inonotus obliquus extract.

[0045] Comparative Example 6

[0046] Compared with Example 1, the Inonotus obliquus extract and Glycyrrhiza inflata extract were replaced with ethoxydiglycol, while maintaining the proportion of quaternary ammonium salt-73.

[0047] Comparative Example 7

[0048] Compared with Example 1, quaternary ammonium salt-73 was replaced with salicylic acid, while maintaining the proportion of other components.

[0049] Comparative Example 8

[0050] Compared with Example 1, the Inonotus obliquus extract was replaced with caffeine, while maintaining the proportion of other components.

[0051] Comparative Example 9

[0052] Compared with Example 1, the Glycyrrhiza inflata extract was replaced with bisabolol, while maintaining the proportion of other components.

[0053] Comparative Example 10

[0054] Compared with Example 1, quaternary ammonium salt-73 was replaced with salicylic acid, the Inonotus obliquus extract was replaced with caffeine, and the Glycyrrhiza inflata extract was replaced with bisabolol, while maintaining the proportion of each component.

[0055] Application Example (blank)

[0056] A gel base material, the formula is shown in Table 1.

[0057]

[0058] The preparation method of the emulsion includes the following steps:

[0059] 1) Put component A into a stirring pot, stir and homogenize at 80 - 85 °C until completely dissolved, and then cool down;

[0060] 2) Pre-dissolve component B, and when the temperature in 1) drops below 60 °C, put component B into the pot and stir until completely dissolved, then cool down;

[0061] 3) Add component C at 40 °C, stir and homogenize until evenly dispersed, cool down below 40 °C, filter and discharge to obtain the product.

[0062] Application Example 1

[0063] Add Example 1 to the application example, with an addition amount of 0.1%, and stir evenly.

[0064] Application Examples 2 - 3

[0065] Compared with Application Example 1, in Application Examples 2 - 3, Example 1 was replaced with Examples 2 - 3 respectively, and other conditions were the same as those in Application Example 1.

[0066] Application Comparative Examples 1 - 10

[0067] Compared with Application Example 1, in Application Comparative Examples 1 - 10, Example 1 was replaced with Comparative Examples 1 - 10 respectively, and other conditions were the same as those in Application Example 1.

[0068] Experimental Example 1 Antibacterial Zone Test

[0069] 1.1 Experimental Method

[0070] Examples 1 - 3 and Comparative Examples 1 - 10 were diluted to 0.1 wt% with deionized water respectively. Referring to the operating method of drug sensitivity test of the Clinical and Laboratory Standards Institute of the United States, the antibacterial properties of the samples against Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis, and Lactobacillus rhamnosus were investigated by the size of the antibacterial zone diameter.

[0071] The sensitivity judgment criteria are as follows:

[0072] Extremely sensitive (>20 mm); Highly sensitive (15 - 20 mm); Moderately sensitive (10 - 14 mm); Low sensitive (<10 mm); Insensitive (0 mm)

[0073] 1.2 Experimental Results

[0074]

[0075] The data shows that quaternary ammonium salt - 73 is the key antibacterial component in the composition. It has a strong inhibitory effect on the pathogenic bacterium Propionibacterium acnes, a moderate inhibitory effect on the pathogenic bacterium Staphylococcus aureus and the resident bacterium Staphylococcus epidermidis, and a weak inhibitory effect on the probiotic Lactobacillus rhamnosus. The compounding of quaternary ammonium salt - 73 and the extract of Glycyrrhiza inflata significantly improves its inhibitory effect on Staphylococcus aureus. Although the extract of Inonotus obliquus has no antibacterial effect, when it is mixed with quaternary ammonium salt - 73 and the extract of Glycyrrhiza inflata, it not only improves the antibacterial effect of the composition on pathogenic bacteria, but also reduces the influence of the composition on resident bacteria and probiotics. It is inferred that it may improve the activity of resident bacteria and probiotics as a probiotic component. Comparative Examples 7 - 10 show that the composition of the present invention is superior to the traditional antibacterial component salicylic acid.

[0076] Example 2 Capsaicin Stimulation Sensory Test

[0077] 2.1 Experimental Method

[0078] After capsaicin contacts the human body, it will activate the sensory receptor TRPV1 to produce discomfort such as burning and stinging. Based on this principle, an in - vivo capsaicin receptor stimulation model was established to evaluate the relief efficacy of Application Examples and Application Comparative Examples.

[0079] Thirty-three subjects, aged 25 to 50 years old, were randomly selected, and two test sites of 1 cm × 1 cm in size were selected on each upper arm of the left and right hands. Filter paper of 1 cm × 1 cm in size was soaked in 10% capsaicin solution, and then the filter paper was applied to the test sites for 30 minutes. After 30 minutes, the filter paper was removed, and the test sample was immediately applied. Among them, one of the test sites was randomly applied with the application example (blank), and the remaining test sites were randomly applied with application examples 1 to 3 and application comparative examples 1 to 10. The pain and burning sensations were observed within 30 minutes, and scores were given according to the perception situation.

[0080] The judgment criteria for relief are as follows: -1 point - the discomfort is aggravated; 0 point - no relief; 1 point - slight relief; 2 points - certain relief; 3 - obvious relief.

[0081]

[0082] The data shows that the extract of Glycyrrhiza inflata Bat. is the key soothing component in the composition. It can act as a sodium channel blocker to play an anti-inflammatory and analgesic role, and the immediate effect is obvious, but the soothing effect weakens at 2 hours. The compounding of the extract of Inonotus obliquus (Ach. Ex Pers.) Pilát and the extract of Glycyrrhiza inflata Bat. significantly improves the more lasting soothing effect. Although quaternary ammonium salt-73 has no soothing effect, when it is mixed with the extract of Inonotus obliquus (Ach. Ex Pers.) Pilát and the extract of Glycyrrhiza inflata Bat., the soothing effect is improved. It is inferred that its effective bacteriostasis plays a good anti-inflammatory effect. The comparative examples 7 to 10 show that the composition of the present invention is superior to the traditional anti-inflammatory ingredient bisabolol, and the traditional antibacterial ingredient salicylic acid will have certain irritation instead.

[0083] Experimental Example 3 Acne Removing Test

[0084] 3.1 Experimental Method

[0085] Fifty acne patients aged 18 to 35 years old were recruited, and application examples 1 to 3 and application comparative examples 1 to 10 were applied in a random half-face test method. The subjects used it once on each side of the face in the morning and evening. At 3 days and 7 days after use, the proportion of the effective rate of acne removal effect was followed up by questionnaire for consumers.

[0086] The effective judgment criteria are as follows:

[0087] The action effects are divided into four levels - very insignificant, insignificant, obvious, and very obvious. The effective rate is the proportion of subjects who recognize obvious and very obvious.

[0088] 3.2 Experimental Results

[0089]

[0090] Data shows that the composition of the present invention has a good effect on removing acne. The subjects agreed that the application examples had obvious and very obvious effects. When the composition of the comparative example was changed, it had a great impact on the efficacy. The composition is superior to the traditional acne-removing ingredients.

[0091] Experimental Example 4 Test for Fading Acne Scars

[0092] 4.1 Experimental Method

[0093] Select the subjects who used Application Examples 1-3 and the blank control above, and use a CL400 skin color tester to measure the L* value and a* value of the facial skin to evaluate the acne scar fading effect of the composition: the larger the L* value, the whiter the skin color and the better the acne scar recovery; the smaller the a* value, the lighter the skin redness and the better the acne scar recovery.

[0094]

[0095] Data shows that the inflating Glycyrrhiza glabra component in the formula is the key component for relieving inflammation and improving inflammatory pigmentation, and Inonotus obliquus is the key component for relieving flushing and promoting barrier repair. The combination of the two and the reasonable combination of the antibacterial component quaternary ammonium salt-73 can effectively achieve antibacterial and anti-inflammatory effects, relieve pain and swelling, fade scars, intervene in the generation of inflammation from the source, thereby reducing the pigmentation and flushing caused by inflammation, and achieving a good conditioning effect.

[0096] The composition of the present invention is reasonably compounded, mild and non-irritating in nature, and the effective synergy of various ingredients has excellent effects on relieving acne symptoms and fading acne scars, and can also promote the rapid repair of damaged skin.

[0097] The specific embodiments of the present invention have been described in detail above, but they are only examples, and the present invention is not limited to the specific embodiments described above. For those skilled in the art, any equivalent modifications and substitutions made to the present invention are also within the scope of the present invention. Therefore, all equivalent transformations and modifications made without departing from the spirit and scope of the present invention should be covered within the scope of the present invention.

Claims

1. A composition for relieving acne symptoms and lightening acne marks, characterized in that The invention is prepared from the following components in parts by weight: 1-20 parts of quaternary ammonium salt-73, 1-30 parts of inonotus obliquus extract and 10-95 parts of glycyrrhiza inflata extract.

2. The composition for relieving acne symptoms and lightening acne marks according to claim 1, characterized in that The invention is prepared from the following components in parts by weight: 5 to 10 parts of quaternary ammonium salt-73, 1 to 10 parts of inonotus obliquus extract and 10 to 90 parts of glycyrrhiza inflata extract.

3. The composition for relieving acne symptoms and lightening acne marks according to claim 1, characterized in that The invention is prepared from the following components in parts by weight: 1-5 parts of quaternary ammonium salt-73, 10-20 parts of inonotus obliquus extract and 10-80 parts of glycyrrhiza inflata extract.

4. The composition for relieving acne symptoms and lightening acne marks according to claim 1, characterized in that The invention is prepared from the following components in parts by weight: 1 to 5 parts of quaternary ammonium salt-73, 1 to 10 parts of inonotus obliquus extract and 20 to 95 parts of glycyrrhiza inflata extract.

5. The method for preparing the composition for relieving acne symptoms and fading acne marks according to any one of claims 1 to 4, characterized in that: The following steps are involved: 1) Dissolve quaternary ammonium salt-73 in polyol and heat to 80-85°C until completely dissolved. 2) After the temperature drops below 40°C, add Glycyrrhiza inflata extract and Inonotus obliquus extract and stir until uniformly dissolved to obtain the composition. In order to improve the stability of the composition, the present invention will additionally use auxiliary solvent polyols, such as at least one of glycerin, propylene glycol, dipropylene glycol, and ethoxydiglycol.

6. Use of the composition for relieving acne symptoms and lightening acne marks according to any one of claims 1 to 4 in anti-acne cosmetics.

7. The use according to claim 6, characterized in that: The amount of the composition for relieving acne symptoms and lightening acne marks added to the anti-acne cosmetic is 0.001-1 wt %.

8. The dosage form of the anti-acne cosmetic includes one of a cream, lotion, aqueous solution, gel, facial mask or facial cleanser.

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