Traditional Chinese medicine composition for treating renal insufficiency and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating renal insufficiency and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. According to the traditional Chinese medicine composition for treating renal insufficiency, astragalus membranaceus and angelica sinensis are used as monarch drugs, motherwort and rheum officinale are used as ministerial drugs, and scalded peach kernels, carthamus tinctorius, salvia miltiorrhiza, ginger processed pinellia, mangnolia officinalis and amomum tsao-ko are used as adjuvant drugs. By combining astragalus membranaceus, angelica sinensis, leonurus, rheum officinale, scalded peach kernels, safflower carthamus, salvia miltiorrhiza, ginger processed pinellia, amomum tsao-ko and mangnolia officinalis, the traditional Chinese medicine composition has excellent effects of tonifying qi, activating blood, harmonizing the stomach and reducing turbidity.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating renal insufficiency and a preparation method thereof. Background Art

[0002] Renal insufficiency is a series of clinical syndromes caused by the decline of glomerular filtration function and the disorder of renal tubule concentration function due to primary or secondary kidney diseases. Renal insufficiency is also known as renal failure disease in traditional Chinese medicine. The main clinical manifestations are reduced urine output, vomiting symptoms, and body edema. If renal insufficiency is not treated in time, it often leads to the occurrence of uremia.

[0003] Traditional Chinese medicine treats renal insufficiency by syndrome differentiation and treatment, specifically focusing on promoting blood circulation to remove blood stasis, clearing heat and promoting diuresis, and tonifying deficiency. For example, in patent CN201410585722.8, a traditional Chinese medicine for treating renal insufficiency is disclosed, which is prepared from 22 parts of pilose antler, 17 parts of poria peel, 14 parts of honeysuckle flower, 18 parts of oyster, 22 parts of salvia miltiorrhiza, 20 parts of polygala tenuifolia, 17 parts of ephedra, 20 parts of wolfberry fruit, 20 parts of cornelian cherry fruit, 20 parts of Chinese yam, 22 parts of scutellaria baicalensis, 17 parts of common sage herb, and 15 parts of coix seed. In patent CN201710926267.7, a drug for treating renal insufficiency is disclosed, which is prepared from 15 parts of bupleurum root, 15 parts of desertliving cistanche, 20 parts of Chinese yam, 15 parts of dodder seed, 15 parts of mulberry fruit, 12 parts of moutan bark, 15 parts of angelica sinensis, 15 parts of bombyx batryticatus, 10 parts of wolfberry fruit, 15 parts of semen vaccariae, 15 parts of calcined oyster, 10 parts of sargassum, 10 parts of laminaria japonica, and 7 parts of liquorice root. Summary of the Invention

[0004] In view of this, the purpose of the present invention is to provide a traditional Chinese medicine composition for treating renal insufficiency and a preparation method thereof. The present invention uses astragalus membranaceus, angelica sinensis, motherwort herb, rhubarb, semen persicae, safflower, salvia miltiorrhiza, pinellia ternata, tsaoko fruit, and magnolia officinalis to prepare a traditional Chinese medicine composition for treating renal insufficiency. In the traditional Chinese medicine composition of the present invention, astragalus membranaceus replenishes qi and raises yang, promotes diuresis and relieves edema, and angelica sinensis nourishes blood and promotes blood circulation. The two are used together, and replenishing qi and activating blood circulation together serve as the monarch drugs. Motherwort herb promotes blood circulation to remove blood stasis, promotes diuresis and relieves edema, and rhubarb purges accumulation, removes blood stasis and dredges menstruation. The two drugs assist the monarch drugs and serve as the minister drugs. Semen persicae, safflower, and salvia miltiorrhiza activate blood circulation, cool blood, and remove blood stasis, while pinellia ternata, magnolia officinalis, and tsaoko fruit dry dampness and resolve phlegm, harmonize the stomach and lower turbidity. The six drugs together serve as the adjuvant drugs. All the drugs in the present invention are combined to have the effects of replenishing qi and activating blood circulation, and harmonizing the stomach and lower turbidity.

[0005] The traditional Chinese medicine composition for treating renal insufficiency of the present invention is prepared from the following Chinese herbal medicines in parts by weight:

[0006] 400 - 500 parts of Astragalus membranaceus, 300 - 400 parts of Angelica sinensis, 400 - 500 parts of Leonurus japonicus, 150 - 250 parts of Rheum palmatum, 300 - 400 parts of semen persicae, 250 - 350 parts of Carthamus tinctorius, 300 - 400 parts of Salvia miltiorrhiza, 300 - 400 parts of Pinellia ternata, 150 - 250 parts of tsaoko fruit, 250 - 350 parts of Magnolia officinalis.

[0007] The preparation method of the traditional Chinese medicine composition for treating renal insufficiency of the present invention includes the following steps:

[0008] (1) Weigh Astragalus membranaceus, Angelica sinensis, Leonurus japonicus, Rheum palmatum, semen persicae, Carthamus tinctorius, Salvia miltiorrhiza, Pinellia ternata, tsaoko fruit, and Magnolia officinalis according to the ratio, mix them and add water for decoction. The weight ratio of the material to the liquid is 1:8 - 15. After the decoction is completed, filter to obtain the filtrate and the residue.

[0009] (2) Add water to the residue for secondary decoction. The ratio of the material to the liquid is 1:5 - 8. After the decoction is completed, filter and collect the filtrate.

[0010] (3) Combine the filtrates prepared by the two decoctions and concentrate under reduced pressure to obtain a clear extract.

[0011] Preferably, the decoction time in step (1) is 1 - 2 hours.

[0012] Preferably, the decoction time in step (2) is 1 - 2 hours.

[0013] Preferably, the relative density of the clear extract in step (3) at 60 °C is 1.05 - 1.09.

[0014] Preferably, it further includes the step of making the clear extract into tablets, capsules or granules.

[0015] More preferably, the clear extract is spray - dried, then dextrin is added, and after mixing evenly, granulation is carried out to obtain granules.

[0016] More preferably, the addition amount of dextrin in step (4) accounts for 1 - 8% of the total mass of the Chinese herbal medicines.

[0017] Astragalus membranaceus is the dried root of the leguminous plant Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. It is dug in spring and autumn, the fibrous roots and root tips are removed, and then dried in the sun. It has the effects of invigorating qi and lifting yang, securing the exterior and stopping sweating, promoting diuresis and alleviating edema, promoting the production of body fluid and nourishing blood, promoting qi circulation and dredging collaterals, expelling pus by supporting healthy qi, and promoting granulation and ulcer healing. It is used for qi deficiency with weakness, poor appetite and loose stools, qi sinking, chronic diarrhea with rectal prolapse, hematochezia and metrorrhagia, spontaneous sweating due to exterior deficiency, qi deficiency edema, internal heat with thirst, blood deficiency and sallow complexion, hemiplegia, arthralgia and numbness, carbuncle and ulcer that are difficult to ulcerate, and chronic ulcer that does not heal.

[0018] Angelica sinensis, the dried root of the plant Angelica sinensis (Oliv.) Diels of the Umbelliferae family. It is dug in late autumn, the fibrous roots and sediment are removed. After the moisture has slightly evaporated, it is tied into small bundles, placed on a shed, and slowly dried by the smoke of fire. It has the effects of enriching blood and promoting blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relaxing bowel movements. It is used for sallow complexion due to blood deficiency, dizziness and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency-cold, rheumatic arthralgia, injury from falls, carbuncles and sores, and constipation due to intestinal dryness.

[0019] Leonurus japonicus, the fresh or dried above-ground parts of the plant Leonurus japonicus Houtt. of the Labiatae family. The fresh product is harvested from the seedling stage in spring to the pre-flowering stage in early summer; the dried product is harvested when the stems and leaves are lush in summer, the flowers have not opened or are just beginning to open, then dried in the sun, or cut into sections and dried in the sun. It has the effects of promoting blood circulation and regulating menstruation, diuretic and detumescence, clearing heat and detoxifying. It is used for irregular menstruation, dysmenorrhea and amenorrhea, retention of lochia, edema with oliguria, and sores and swelling toxins.

[0020] Rheum palmatum, the dried root and rhizome of the plant Rheum palmatum L., Rheum tanguticum Maxim. ex Balf. or Rheum officinale Baill. of the Polygonaceae family. It is dug in late autumn when the stems and leaves wither or before germination in the next spring, the fine roots are removed, the outer bark is scraped off, cut into slices or segments, strung together with ropes and dried, or directly dried. It has the effects of purging heat and removing stagnation, clearing heat and purging fire, cooling blood and detoxifying, removing stasis and dredging menstruation, promoting diuresis and reducing jaundice. It is used for constipation due to accumulation of heat and stagnation, hematemesis and epistaxis due to blood heat, red eyes and sore throat, carbuncles and furuncles, appendicitis with abdominal pain, amenorrhea due to blood stasis, postpartum stasis obstruction, injury from falls, dysentery due to damp-heat, jaundice with red urine, stranguria, and edema.

[0021] Processed Semen Persicae: Take the clean Semen Persicae, remove the skin according to the processing method (General Rule 0213 in Volume I of the Chinese Pharmacopoeia 2020 Edition), and crush it before use. It has the effects of promoting blood circulation to remove stasis, moistening the intestines and relaxing bowel movements, relieving cough and asthma. It is used for amenorrhea and dysmenorrhea, mass in the abdomen, lung abscess and appendicitis, injury from falls, constipation due to intestinal dryness, and cough and asthma.

[0022] Carthamus tinctorius, the dried flower of the plant Carthamus tinctorius L. of the Compositae family. It is picked when the flower turns from yellow to red in summer, and dried in the shade or in the sun. It has the effects of promoting blood circulation and dredging menstruation, dispersing stasis and relieving pain. It is used for amenorrhea, dysmenorrhea, retention of lochia, mass in the abdomen, chest pain due to chest impediment, abdominal pain due to stasis, stabbing pain in the chest and hypochondrium, injury from falls, and swelling and pain of sores and ulcers.

[0023] Salvia miltiorrhiza, the dried root and rhizome of the plant Salvia miltiorrhiza Bge. of the Labiatae family. It is dug in spring and autumn, the sediment is removed, and then dried. It has the effects of promoting blood circulation to remove stasis, dredging menstruation and relieving pain, clearing the heart and relieving vexation, cooling blood and eliminating carbuncles. It is used for chest pain due to chest impediment, abdominal pain in the epigastrium and hypochondrium, mass accumulation, arthralgia due to heat obstruction, restlessness and insomnia, irregular menstruation, dysmenorrhea and amenorrhea, and swelling and pain of sores and ulcers.

[0024] Pinellia ternata (Thunb.) Breit. processed product. Take the cleaned Pinellia ternata, separate them by size, soak in water until there is no dry core inside, then take out; separately slice ginger for decoction, add alum and Pinellia ternata and cook until thoroughly cooked, take out, dry in the air, or dry until semi-dry and then dry; or cut into thin slices and dry. For every 100 kg of cleaned Pinellia ternata, use 25 kg of ginger and 12.5 kg of alum. It has the effects of warming the middle-jiao to resolve phlegm, and lowering adverse qi to stop vomiting. It is used for vomiting due to retention of phlegm-fluid, and fullness and discomfort in the epigastric region.

[0025] Tsaoko Fruit, the dried ripe fruit of the Zingiberaceae plant Amomum tsao-ko Crevost et Lemaire. Harvest when the fruit is ripe in autumn, remove impurities, and dry in the sun or by low-temperature drying. It has the effects of drying dampness and warming the middle-jiao, and intercepting malaria and resolving phlegm. It is used for internal obstruction of cold-dampness, distending pain in the epigastric and abdominal regions, fullness and discomfort with vomiting, malaria with chills and fevers, and epidemic febrile disease with fever.

[0026] Magnolia Bark, the dried trunk bark, root bark and branch bark of the Magnoliaceae plant Magnolia officinalis Rehd.etWils. or Magnolia officinalis Rehd.etWils.var.biloba Rehd.etWils.. Peel from April to June, directly dry the root bark and branch bark in the shade; for the trunk bark, slightly boil in boiling water, then pile up in a shady and humid place, "sweat" until the inner surface turns purple-brown or brownish-brown, steam until soft, take out, roll into a tube shape, and dry. It has the effects of drying dampness and dissipating phlegm, and lowering qi to relieve fullness. It is used for injury to the middle-jiao by dampness stagnation, fullness and discomfort in the epigastric region with vomiting and diarrhea, food accumulation and qi stagnation, abdominal distension and constipation, and cough and dyspnea due to retention of phlegm-fluid.

[0027] Compared with the prior art, the present invention has the following beneficial effects: The traditional Chinese medicine composition for treating renal insufficiency in the present invention uses Astragalus membranaceus and Angelica sinensis as the monarch drugs, Leonurus japonicus and Rheum palmatum as the minister drugs, and prepared semen persicae, safflower, Salvia miltiorrhiza, Pinellia ternata (Thunb.) Breit. processed product, Magnolia Bark, Tsaoko Fruit as the assistant drugs. The present invention combines Astragalus membranaceus, Angelica sinensis, Leonurus japonicus, Rheum palmatum, prepared semen persicae, safflower, Salvia miltiorrhiza, Pinellia ternata (Thunb.) Breit. processed product, Tsaoko Fruit, Magnolia Bark, and has excellent effects of benefiting qi and promoting blood circulation, and harmonizing the stomach and lowering turbidity. Detailed Embodiments

[0028] To make the objectives, technical solutions and advantages of the present invention clearer, the preferred implementation solutions of the present invention will be further described in detail below with reference to the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0029] Embodiment 1

[0030] A traditional Chinese medicine composition for treating renal insufficiency, and its preparation method is as follows:

[0031] (1) Weigh 469 parts by weight of Astragalus membranaceus, 375 parts of Angelica sinensis, 469 parts of Leonurus japonicus, 188 parts of Rheum palmatum, 375 parts of semen persicae, 281 parts of Carthamus tinctorius, 375 parts of Salvia miltiorrhiza, 375 parts of Pinellia ternata, 188 parts of tsaoko fruit, and 281 parts of Magnolia officinalis. After mixing, add water and decoct for 1 h, where the weight ratio of the material to the liquid is 1:10. After decocting, filter to obtain a filtrate and filter residue;

[0032] (2) Add water to the filter residue and conduct a secondary decoction for 1 h, where the ratio of the material to the liquid is 1:7. After decocting, filter and collect the filtrate;

[0033] (3) Combine the filtrates prepared from the two decoctions and concentrate under reduced pressure to obtain a clear extract with a relative density of 1.08;

[0034] (4) Spray-dry the clear extract to obtain a medicinal powder;

[0035] (5) Weigh dextrin accounting for 5% of the total mass of the Chinese herbal medicines in step (1). Mix the weighed dextrin with the product of step (4) and granulate to obtain granules.

[0036] Example 2

[0037] A traditional Chinese medicine composition for treating renal insufficiency, and its preparation method is as follows:

[0038] (1) Weigh 400 parts by weight of Astragalus membranaceus, 400 parts of Angelica sinensis, 500 parts of Leonurus japonicus, 250 parts of Rheum palmatum, 300 parts of semen persicae, 350 parts of Carthamus tinctorius, 400 parts of Salvia miltiorrhiza, 300 parts of Pinellia ternata, 150 parts of tsaoko fruit, and 250 parts of Magnolia officinalis. After mixing, add water and decoct for 1 h, where the weight ratio of the material to the liquid is 1:10. After decocting, filter to obtain a filtrate and filter residue;

[0039] (2) Add water to the filter residue and conduct a secondary decoction for 1 h, where the ratio of the material to the liquid is 1:7. After decocting, filter and collect the filtrate;

[0040] (3) Combine the filtrates prepared from the two decoctions and concentrate under reduced pressure to obtain a clear extract with a relative density of 1.06;

[0041] (4) Spray-dry the clear extract to obtain a medicinal powder;

[0042] (5) Weigh dextrin accounting for 7% of the total mass of the Chinese herbal medicines in step (1). Mix the weighed dextrin with the product of step (4) and granulate to obtain granules.

[0043] Example 3

[0044] A traditional Chinese medicine composition for treating renal insufficiency, and its preparation method is as follows:

[0045] (1) Weigh 500 parts of Astragalus membranaceus, 300 parts of Angelica sinensis, 400 parts of Leonurus japonicus, 150 parts of Rheum palmatum, 400 parts of semen persicae, 250 parts of Carthamus tinctorius, 300 parts of Salvia miltiorrhiza, 400 parts of Pinellia ternata, 250 parts of tsaoko fruit, and 350 parts of Magnolia officinalis by weight. After mixing, add water and decoct for 1 h, where the weight ratio of the material to the liquid is 1:10. After the decoction is completed, filter to obtain a filtrate and residues.

[0046] (2) Add water to the residues and decoct them for a second time for 1 h, where the ratio of the material to the liquid is 1:7. After the decoction is completed, filter and collect the filtrate.

[0047] (3) Combine the filtrates prepared from the two decoctions and concentrate them under reduced pressure to obtain a clear extract with a relative density of 1.09.

[0048] (4) Spray-dry the clear extract to obtain a medicinal powder.

[0049] (5) Weigh dextrin accounting for 8% of the total mass of the Chinese herbal medicines in step (1). Mix the weighed dextrin with the product of step (4) and granulate to obtain granules.

[0050] Comparative Example 1

[0051] A traditional Chinese medicine composition for treating renal insufficiency, the preparation method of which refers to Example 1, except that the parts by weight of the Chinese herbal medicines used are as follows:

[0052] 600 parts of Astragalus membranaceus, 200 parts of Angelica sinensis, 469 parts of Leonurus japonicus, 188 parts of Rheum palmatum, 375 parts of semen persicae, 281 parts of Carthamus tinctorius, 500 parts of Salvia miltiorrhiza, 200 parts of Pinellia ternata, 188 parts of tsaoko fruit, and 281 parts of Magnolia officinalis.

[0053] All the remaining steps are the same as those in Example 1.

[0054] Comparative Example 2

[0055] A traditional Chinese medicine composition for treating renal insufficiency, the preparation method of which refers to Example 1, except that the parts by weight of the Chinese herbal medicines used are as follows:

[0056] 469 parts of Astragalus membranaceus, 375 parts of Angelica sinensis, 188 parts of Rheum palmatum, 545 parts of semen persicae, 410 parts of Carthamus tinctorius, 545 parts of Salvia miltiorrhiza, 375 parts of Pinellia ternata, 188 parts of tsaoko fruit, and 281 parts of Magnolia officinalis.

[0057] All the remaining steps are the same as those in Example 1.

[0058] Comparative Example 3

[0059] A traditional Chinese medicine composition for treating renal insufficiency, the preparation method of which refers to Example 1, except that the parts by weight of the Chinese herbal medicines used are as follows:

[0060] 469 parts of Astragalus membranaceus, 375 parts of Angelica sinensis, 469 parts of Leonurus japonicus, 188 parts of Rheum officinale, 375 parts of semen persicae, 281 parts of Carthamus tinctorius, 375 parts of Salvia miltiorrhiza, 375 parts of Pinellia ternata, 469 parts of Magnolia officinalis.

[0061] All the remaining steps are the same as those in Example 1.

[0062] Comparative Example 4

[0063] A traditional Chinese medicine composition for treating renal insufficiency, the preparation method of which refers to Example 1, the difference is that the weight parts of the Chinese herbal medicines used are as follows:

[0064] 469 parts of Astragalus membranaceus, 375 parts of Angelica sinensis, 469 parts of Leonurus japonicus, 188 parts of Rheum officinale, 375 parts of semen persicae, 281 parts of Carthamus tinctorius, 375 parts of Salvia miltiorrhiza, 375 parts of Pinellia ternata, 469 parts of Tsaoko fruit.

[0065] All the remaining steps are the same as those in Example 1.

[0066] The traditional Chinese medicine compositions prepared in Examples 1 to 3 and Comparative Examples 1 to 4 were subjected to animal experiments for detection, and the specific methods are as follows:

[0067] SD male rats, weighing 200±20 g, after adaptive feeding, were randomly divided into 10 groups, with 8 rats in each group, including a blank control group, a model group, a positive control group, Example 1-3 groups, and Comparative Example 1-4 groups.

[0068] The blank control group was intragastrically administered with an equal amount of normal saline, and the remaining groups were intragastrically administered with an adenine suspension solution (1 g of adenine was dissolved in 40 mL of normal saline to prepare a 2.5% concentration) 200 mg / kg every morning, once a day for 21 consecutive days. At the same time, each administration group was intragastrically administered with the corresponding drug every afternoon. The positive control group was intragastrically administered with 2 g / kg of Niaoduqing granules, and each Example group and Comparative Example group were intragastrically administered with the corresponding composition 3 g / kg, dissolved in distilled water, the administration volume was 10 mL / kg, and the blank control group and the model group were intragastrically administered with an equal amount of distilled water, and the drug was continuously administered for 35 days.

[0069] After administration on the 35th day, the urine of each group of rats was collected. During the urine collection period, the rats were fasted and not given water. The urine was centrifuged at 3000 r / min, and the supernatant was used to detect 24h-UTP (total urine protein) using a urine protein quantification kit. Then, each group of rats was anesthetized by intraperitoneal injection of 2% pentobarbital (25 mg / kg), about 1.5 mL of blood was taken from the orbital cavity, centrifuged at 3000 r / min for 10 min, and the serum was separated to detect Scr (creatinine) using the picric acid method and BUN (blood urea nitrogen) using the urease method. The results are shown in Table 1.

[0070] Table 1

[0071] Group 24h-UTP (mg / L) Scr (μmol / L) BUN (mmol / L) Blank control group 28.90±4.24 45.95±7.74 6.90±1.23 Model group <![CDATA[43.91±8.57 ** > <![CDATA[151.22±23.73 ** > <![CDATA[30.86±5.09 ** > Positive control group 39.40±6.51 <![CDATA[100.04±11.10 ## > <![CDATA[17.46±4.14 # > Example 1 group <![CDATA[34.05±5.43 # > <![CDATA[92.73±9.19 ## > <![CDATA[16.31±3.92 # > Example 2 group <![CDATA[36.13±5.72 # > <![CDATA[98.82±9.55 ## > <![CDATA[17.12±4.36 # > Example 3 group <![CDATA[36.76±5.69 # > <![CDATA[99.16±10.32 ## > <![CDATA[17.33±4.28 # > Comparative example 1 group <![CDATA[39.48±6.28 △ > <![CDATA[120.56±11.39 #△ > <![CDATA[21.83±4.54 #△ > Comparative example 2 group <![CDATA[41.02±6.92 △ > <![CDATA[125.26±12.51 #△ > <![CDATA[25.24±5.43 #△ > Comparative example 3 group <![CDATA[40.53±5.78 △ > <![CDATA[123.67±11.44 #△ > <![CDATA[23.97±5.01 #△ > Comparative example 4 group <![CDATA[40.66±6.65 △ > <![CDATA[122.70±11.65 #△ > <![CDATA[23.62±4.75 #△ >

[0072] Note: Compared with the blank control group, ** P < 0.01; compared with the model group, # P < 0.05, ## P < 0.01; compared with the Example 1 group, △ P < 0.05.

[0073] Compared with the blank control group, after intragastric administration of adenine, the rats in the model group gradually showed manifestations such as polydipsia, hypophagia, polyuria, slow weight gain, dull reaction, listlessness, and rough hair. Moreover, the levels of 24h-UTP, Scr, and BUN were all significantly increased (P < 0.01), indicating successful model establishment. Compared with the model group, the levels of 24h-UTP, Scr, and BUN in each drug administration group decreased. The decrease level in the Example group was significant (P < 0.05, P < 0.01), and there were significant differences compared with each comparative example group (P < 0.05).

[0074] The embodiments described above are some, but not all, of the embodiments of the present invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts fall within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating renal insufficiency, characterized in that: It is prepared from the following Chinese herbal medicines in parts by weight: 400-500 parts of astragalus, 300-400 parts of angelica, 400-500 parts of motherwort, 150-250 parts of rhubarb, 300-400 parts of stewed peach kernels, 250-350 parts of safflower, 300-400 parts of salvia miltiorrhiza, 300-400 parts of pinellia tuber, 150-250 parts of amomum villosum, and 250-350 parts of magnolia bark.

2. The method for preparing the Chinese medicine composition for treating renal insufficiency according to claim 1, characterized in that: The following steps are involved: (1) Weigh astragalus, angelica, motherwort, rhubarb, stewed peach kernel, safflower, salvia miltiorrhiza, pinellia tuber, tsaoko, and magnolia officinalis according to proportion, add water to the mixture and boil, wherein the weight ratio of the material to the liquid is 1:8-15, and filter after boiling to obtain a filtrate and a filter residue; (2) adding water to the filter residue for secondary decoction, wherein the solid-liquid ratio is 1:5-8, and filtering and collecting the filtrate after the decoction is completed; (3) The filtrates prepared from the two decoctions are combined and concentrated under reduced pressure to obtain a clear paste.

3. The preparation method according to claim 2, characterized in that: The decoction time in step (1) is 1 to 2 hours.

4. The preparation method according to claim 2, characterized in that: The decoction time in step (2) is 1 to 2 hours.

5. The preparation method according to claim 2, characterized in that: The relative density of the clear paste in step (3) at 60° C. is 1.05 to 1.

09.

6. The preparation method according to claim 2, characterized in that: The method also comprises the step of preparing the clear paste into tablets, capsules or granules.

7. The preparation method according to claim 6, characterized in that: The clear paste is spray-dried, and then dextrin is added, mixed, and granulated to obtain granules.

8. The preparation method according to claim 7, characterized in that: The amount of dextrin added in step (4) accounts for 1 to 8% of the total mass of the Chinese herbal medicine.

9. Use of the Chinese medicine composition for treating renal insufficiency according to claim 1 in preparing a medicine for treating renal insufficiency.