Water-bindered pill formula and preparation method thereof
By preparing uniformly formulated water pills, the problems of uneven mixing of traditional Chinese medicine powders and inconsistent distribution of ingredients are solved, the consistency and stability of the efficacy of the medicine is improved, and the feasibility of personalized treatment plans is achieved.
Patent Information
- Application Number
- CN202510169391.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-17
- Publication Date
- 2025-05-30
AI Technical Summary
The traditional water pill production process has problems such as uneven mixing of powders and inconsistent distribution of ingredients, which leads to poor consistency and stability of the efficacy, and it is difficult to make flexible adjustments based on the conditions and needs of different patients.
A water pill formula and preparation method are provided, by preparing and crushing medicinal materials, making molds with adhesives, gradually increasing the powder by rotating and spraying water or adhesives, forming uniform water pills, and ensuring quality through drying and screening.
The uniform mixing of the medicine powder is achieved, the content of each water pill is small, which improves the consistency and stability of the medicine effect. It can be flexibly adjusted according to the needs of different patients to achieve a personalized treatment plan.
Abstract
Description
Technical Field
[0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a water pill formula and a preparation method thereof. Background Art
[0002] As a traditional Chinese medicine dosage form, water pills have a long history and wide application. It is made by making Chinese herbal medicine powder into small pellets, which have the advantages of easy to take, easy to absorb, and long-lasting efficacy. However, there are many shortcomings in the traditional water pill production process. In the traditional water pill production process, due to uneven mixing of drug powder or inconsistent distribution of drug powder during the pill making process, the ingredient content of each water pill varies greatly, affecting the consistency and stability of the efficacy. Traditional water pill production mostly relies on manual operations, such as demoulding, pill making and other steps, which are easily affected by the technical level of the operator, and the existing water pill formula cannot be flexibly adjusted according to the specific conditions and needs of different patients to achieve personalized treatment plans and improve the targetedness and effectiveness of treatment.
[0003] In summary, traditional water pills and production processes have deficiencies in many aspects, and a water pill formula and a stable preparation method are urgently needed to solve the above problems. Summary of the invention
[0004] The purpose of the present invention is to provide a water pill formula and a preparation method thereof.
[0005] To achieve the above object, the present invention provides the following technical solution: a water pill formula, the raw materials by weight include: 70-80 parts of bupleurum, 70-80 parts of curcuma, 45-55 parts of scutellaria, 70-80 parts of coptis, 70-80 parts of the white peony root, 45-55 parts of corrugated paper, 70-80 parts of tetrandra, 45-55 parts of nardostachys, 25-35 parts of preparatory liquorice, 70-80 parts of heishunpian, 45-55 parts of flos julibrissin, 45-55 parts of schoenensis leaf, 45-55 parts of caulis affine, 45-55 parts of moutan bark, 45-55 parts of chuanxiong, and 45-55 parts of persica.
[0006] Preferably, the raw materials include by weight: 70 parts of Bupleurum, 70 parts of Curcuma, 45 parts of Scutellaria, 70 parts of Coptidis, 80 parts of the White Paeony Root, 45 parts of Fructus Coriolus, 80 parts of Tetrandrakia Tetrandrae, 55 parts of Nigella Sativa, 35 parts of Radix Glycyrrhizae Preparata, 80 parts of Heishun Pian, 45 parts of Flos Albiziae, 55 parts of Caulis Polygoni Multiflori, 55 parts of Cortex Moutan, 45 parts of Rhizoma Chuanxiong, 55 parts of Semen Persicae.
[0007] Preferably, the raw materials include by weight: 80 parts of Bupleurum chinense, 80 parts of Curcuma aromatica, 55 parts of Scutellaria baicalensis, 80 parts of Coptis chinensis, 70 parts of Paeonia lactiflora, 55 parts of Concha arcae, 70 parts of Sinomenium acutum, 45 parts of Nidus vespae, 25 parts of Radix glycyrrhizae preparata, 70 parts of Aconiti Lateralis Radix Praeparata, 55 parts of Flos albizziae, 45 parts of Caulis polygonati multiflori, 45 parts of Cortex moutan, 55 parts of Rhizoma chuanxiong, 45 parts of Semen persicae.
[0008] Preferably, the raw materials include, by weight: 75 parts of Bupleurum chinense, 75 parts of Curcuma aromatica, 50 parts of Scutellaria baicalensis, 75 parts of Coptis chinensis, 75 parts of Paeonia lactiflora, 50 parts of Concha arcae, 75 parts of Sinomenium acutum, 50 parts of Nidus vespae, 30 parts of Radix glycyrrhizae preparata, 75 parts of Aconiti Lateralis Radix Praeparata, 50 parts of Flos albizziae, 50 parts of Caulis polygonati multiflori, 50 parts of Cortex moutan, 50 parts of Rhizoma chuanxiong, 50 parts of Semen persicae.
[0009] A preparation method of a water pill formula, characterized by comprising the following steps: S1. Medicinal material preparation: Roast and pulverize according to the ratio to make fine powder; S2. Seedling formation: Make small particles from part of the medicinal powder with an appropriate binder to make a mold; S3. Pill rolling: Put the mold into a pill rolling pot, and gradually add medicinal powder by rotating and spraying water or binder to make the mold gradually grow into water pills; S4. Screening: Screen the water pills with an appropriate sieve to remove too large or too small pill grains; S5. Drying: Dry the screened water pills to remove moisture; S6. Packaging: Package the dried pills.
[0010] Preferably, in the step S5, the diameter of the water pills is 3 - 5 mm.
[0011] Preferably, in the step S5, the drying temperature is 40 - 50 °C, the drying time is 2 - 3 hours, and the water content of the water pills is reduced to less than 5%.
[0012] Preferably, in the step S2, the diameter of the mold is 0.5 - 1 mm.
[0013] Compared with the prior art, the beneficial effects of the present invention are: The water pill formula obtained through preparation has the medicinal powder evenly mixed, and the component content difference of each water pill is small, greatly improving the consistency and stability of the medicinal effect, not being easily affected by the technical level of the operator, and the prepared water pill formula achieves the effects of soothing the liver and relieving depression, clearing heat and detoxifying, promoting blood circulation and removing stasis, nourishing the blood and softening the liver, warming the kidney and assisting yang, softening hardness and dissipating nodules, dispelling wind and relieving pain.
[0014] Comprehensive conditioning can be carried out: providing comprehensive therapeutic effects and being applicable to the comprehensive conditioning of various diseases.
[0015] Moreover, it can be flexibly adjusted according to the specific conditions and needs of different patients to achieve personalized treatment plans, improving the pertinence and effectiveness of treatment. Detailed implementation manners
[0016] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Apparently, the described embodiments are only a part rather than all of the embodiments of the present invention.
[0017] A water pill formula is provided, and the raw materials include, by weight parts: 70 - 80 parts of Bupleuri Radix, 70 - 80 parts of Curcumae Radix, 45 - 55 parts of Scutellariae Radix, 70 - 80 parts of Coptidis Rhizoma, 70 - 80 parts of Paeoniae Radix Alba, 45 - 55 parts of Concha Arcae, 70 - 80 parts of Sinomenii Caulis, 45 - 55 parts of Nidus Vespae, 25 - 35 parts of Glycyrrhizae Radix Preparata, 70 - 80 parts of Aconiti Lateralis Radix Praeparata, 45 - 55 parts of Albizziae Flos, 45 - 55 parts of Polygoni Multiflori Caulis, 45 - 55 parts of Moutan Cortex, 45 - 55 parts of Chuanxiong Rhizoma, 45 - 55 parts of Persicae Semen.
[0018] Among them, Bupleuri Radix: Soothes the liver and relieves depression, clears heat and detoxifies, and is commonly used to treat symptoms such as liver qi stagnation and fever.
[0019] Curcumae Radix: Promotes blood circulation and removes blood stasis, cools blood and relieves pain, and helps to improve blood circulation and relieve pain.
[0020] Scutellariae Radix: Clears heat and dries dampness, purges fire and detoxifies, and is widely used to treat symptoms such as febrile diseases and sore throats.
[0021] Coptidis Rhizoma: Clears heat and dries dampness, purges fire and detoxifies, and is especially suitable for symptoms such as hyperactivity of heart fire and oral ulcers.
[0022] Paeoniae Radix Alba: Nourishes the blood and soothes the liver, relieves spasm and pain, and helps to regulate liver function and relieve spasm and pain.
[0023] Concha Arcae: Softens hardness and dissipates nodules, inhibits acid and relieves pain, and is commonly used to treat symptoms such as stomachache and acid regurgitation.
[0024] Sinomenii Caulis: Promotes qi flow and relieves pain, promotes diuresis and reduces swelling, and helps to improve symptoms of qi stagnation and fluid retention.
[0025] Nidus Vespae: Detoxifies and reduces swelling, kills insects and relieves itching, and is suitable for symptoms such as skin itching and sores.
[0026] Glycyrrhizae Radix Preparata: Harmonizes the middle and relieves spasm, coordinates various herbs, helps to relieve the bitter taste, and enhances the overall medicinal effect.
[0027] Aconiti Lateralis Radix Praeparata: Warms the kidney and aids yang, dispels cold and relieves pain, and is suitable for symptoms such as aversion to cold and soreness and weakness of the waist and knees caused by kidney yang deficiency.
[0028] Albizziae Flos: Soothes the mind and relieves depression, promotes blood circulation and dredges collaterals, and helps to improve mood and relieve anxiety and insomnia.
[0029] Caulis Polygoni Multiflori: Nourishes the heart and soothes the mind, dispels wind and dredges collaterals, applicable to symptoms such as palpitation and insomnia, rheumatic arthralgia, etc.
[0030] Cortex Moutan: Clears heat and cools blood, promotes blood circulation and removes stasis, helps improve symptoms of blood heat and promotes blood circulation.
[0031] Rhizoma Chuanxiong: Promotes blood circulation and qi movement, dispels wind and relieves pain, widely used in symptoms such as headache, rheumatic pain, etc.
[0032] Semen Persicae: Promotes blood circulation and removes stasis, moistens the intestines and relieves constipation, helps improve blood circulation and prevent constipation.
[0033] Among them, the preparation method of the water pill formula is as follows: First, prepare the medicinal materials: Process and pulverize them according to the ratio to make fine powder. Make the initial pellets: Make part of the medicinal powder into small pellets with an appropriate binder to form the mold. Among them, the binder is specifically water or honey. Then, pan-pill: Put the mold into the pan-pill pot, and by rotating and spraying water or binder, continuously add the medicinal powder to gradually increase the mold into water pills. After that, conduct screening: Screen the water pills with an appropriate sieve to remove the too large or too small pill grains. Then, conduct drying: Dry the screened water pills to remove moisture. Finally, package: Package the dried ones.
[0034] The following is a specific description. Example 1 This example provides a water pill formula. The raw materials include, by weight: 70 parts of Bupleuri Radix, 70 parts of Curcumae Radix, 45 parts of Scutellariae Radix, 70 parts of Coptidis Rhizoma, 80 parts of Paeoniae Radix Alba, 45 parts of Concha Arcae, 80 parts of Stephaniae Tetrandrae Radix, 55 parts of Nidus Vespae, 35 parts of Glycyrrhizae Radix Preparata, 80 parts of Aconiti Lateralis Radix Praeparata, 45 parts of Albizziae Flos, 55 parts of Caulis Polygoni Multiflori, 55 parts of Cortex Moutan, 45 parts of Rhizoma Chuanxiong, 55 parts of Semen Persicae.
[0035] A preparation method of a water pill formula, the specific process is as follows: First, prepare the medicinal materials: After processing, use a high-speed pulverizer to pulverize them into fine powder, pass through a 120-mesh sieve, and set aside.
[0036] Among them, the specific ratio of the Chinese medicinal materials is: 70 parts of Bupleuri Radix, 70 parts of Curcumae Radix, 45 parts of Scutellariae Radix, 70 parts of Coptidis Rhizoma, 80 parts of Paeoniae Radix Alba, 45 parts of Concha Arcae, 80 parts of Stephaniae Tetrandrae Radix, 55 parts of Nidus Vespae, 35 parts of Glycyrrhizae Radix Preparata, 80 parts of Aconiti Lateralis Radix Praeparata, 45 parts of Albizziae Flos, 55 parts of Caulis Polygoni Multiflori, 55 parts of Cortex Moutan, 45 parts of Rhizoma Chuanxiong, 55 parts of Semen Persicae.
[0037] Then, perform mold-making: Take a portion of the medicinal powder, add an appropriate amount of water or honey, stir evenly, and then use an extrusion granulator to make fine granules with a diameter of about 0.5 - 1 mm as the mold.
[0038] Next, perform pill-panning: Place the mold in a pill-panning pot, start the rotating device, and at the same time spray water or binder through a spraying device, and continuously add the medicinal powder to gradually increase the mold into water pills with a diameter of about 3 - 5 mm.
[0039] After that, perform screening: Use a vibrating sieve to screen the water pills, remove the pill grains with a diameter less than 3 mm or greater than 5 mm, and retain the qualified water pills.
[0040] Then, perform drying: Place the screened water pills in an oven and dry them at 40 - 50 °C for 2 - 3 hours until the water content of the water pills drops below 5%.
[0041] Next, coating can be performed as needed: The water pills can be coated to increase stability or improve taste, etc. If coating is required, a film coating material (such as hydroxypropyl methylcellulose) can be selected and the coating treatment is carried out in a coating pan, with the thickness controlled at 0.1 - 0.2 mm.
[0042] After that, according to the detection methods specified in the Chinese Pharmacopoeia, check the appearance, size, hardness, dissolution time limit and other indicators of the water pills to ensure compliance with the quality requirements.
[0043] Finally, perform packaging: Use an aluminum-plastic blister packaging machine to package the qualified water pills, with 10 pills per plate, 10 plates per box, and an additional paper packaging box to ensure the safety of transportation and storage.
[0044] Example 2 Different from Example 1, a water pill formula is provided. The raw materials include, by weight: 80 parts of Bupleurum chinense, 80 parts of Curcuma aromatica, 55 parts of Scutellaria baicalensis, 80 parts of Coptis chinensis, 70 parts of Paeonia lactiflora, 55 parts of Concha Arcae, 70 parts of Sinomenium acutum, 45 parts of Nidus Vespae, 25 parts of Radix Glycyrrhizae Preparata, 70 parts of Aconiti Lateralis Praeparata, 55 parts of Flos Albiziae, 45 parts of Caulis Polygoni Multiflori, 45 parts of Cortex Moutan, 55 parts of Rhizoma Chuanxiong, 45 parts of Semen Persicae.
[0045] Example 3 Different from Example 1, a water pill formula is provided. The raw materials include, by weight: 75 parts of Bupleurum chinense, 75 parts of Curcuma aromatica, 50 parts of Scutellaria baicalensis, 75 parts of Coptis chinensis, 75 parts of Paeonia lactiflora, 50 parts of Concha Arcae, 75 parts of Sinomenium acutum, 50 parts of Nidus Vespae, 30 parts of Radix Glycyrrhizae Preparata, 75 parts of Aconiti Lateralis Praeparata, 50 parts of Flos Albiziae, 50 parts of Caulis Polygoni Multiflori, 50 parts of Cortex Moutan, 50 parts of Rhizoma Chuanxiong, 50 parts of Semen Persicae.
[0046] The prepared water pill formula has evenly mixed medicinal powders, with small differences in the ingredient content of each water pill, greatly improving the consistency and stability of the medicinal effects, being not easily affected by the technical level of operators, and the prepared water pill formula achieves the effects of soothing the liver and relieving depression, clearing heat and detoxifying, promoting blood circulation and removing blood stasis, nourishing the liver and softening the liver, warming the kidney and boosting yang, softening hardness and dissipating nodules, dispelling wind and relieving pain.
[0047] Comprehensive conditioning can be carried out: providing comprehensive treatment effects and being applicable to the comprehensive conditioning of various diseases.
[0048] Moreover, it can be flexibly adjusted according to the specific conditions and needs of different patients to achieve personalized treatment plans, improving the pertinence and effectiveness of treatment.
[0049] Moreover, it can be flexibly adjusted according to the specific conditions and needs of different patients to achieve personalized treatment plans, improving the pertinence and effectiveness of treatment.
[0050] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and without departing from the spirit or basic characteristics of the present invention, the present invention can be implemented in other specific forms. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be embraced within the present invention.
Claims
1. A water pill formula, characterized in that: The raw materials include by weight: 70-80 parts of bupleurum, 70-80 parts of curcuma, 45-55 parts of scutellaria, 70-80 parts of coptis, 70-80 parts of the white peony root, 45-55 parts of corrugated paper, 70-80 parts of tetrandra, 45-55 parts of nardostachys, 25-35 parts of preparatory liquorice, 70-80 parts of heishunpian, 45-55 parts of flos julibrissin, 45-55 parts of schoenensis leaf, 45-55 parts of caulis affine, 45-55 parts of moutan bark, 45-55 parts of chuanxiong, and 45-55 parts of persica.
2. A water pill formula according to claim 1, characterized in that: The raw materials include by weight: 70 parts of Bupleurum, 70 parts of Curcuma, 45 parts of Scutellaria, 70 parts of Coptidis, 80 parts of the White Paeony Root, 45 parts of Fructus Coriolus, 80 parts of Tetrandrakia Tetrandrae, 55 parts of Nigella Sativa, 35 parts of Radix Glycyrrhizae Preparata, 80 parts of Heishun Pian, 45 parts of Flos Albiziae, 55 parts of Caulis Polygoni Multiflori, 55 parts of Cortex Moutan, 45 parts of Rhizoma Chuanxiong, 55 parts of Semen Persicae.
3. A water pill formula according to claim 1, characterized in that: The raw materials include by weight: 80 parts of Bupleurum, 80 parts of Curcuma, 55 parts of Scutellaria, 80 parts of Coptidis, 70 parts of the White Paeonia, 55 parts of Fructus Coriolus, 70 parts of Tetrandrakia Tetrandrae, 45 parts of Nigella Sativa, 25 parts of Radix Glycyrrhizae Preparata, 70 parts of Heishun Pian, 55 parts of Flos Albiziae, 45 parts of Caulis Polygoni Multiflori, 45 parts of Cortex Moutan, 55 parts of Rhizoma Chuanxiong, 45 parts of Semen Persicae.
4. A water pill formula according to claim 1, characterized in that: The raw materials include by weight: 75 parts of Bupleurum, 75 parts of Curcuma, 50 parts of Scutellaria, 75 parts of Coptidis, 75 parts of the White Paeonia, 50 parts of Fructus Coriolus, 75 parts of Tetrandrakia Tetrandrae, 50 parts of Nigella Sativa, 30 parts of Radix Glycyrrhizae Preparata, 75 parts of Heishun Pian, 50 parts of Flos Albiziae, 50 parts of Caulis Polygoni Multiflori, 50 parts of Cortex Moutan, 50 parts of Rhizoma Chuanxiong, 50 parts of Semen Persicae.
5. A method for preparing a water pill formulation according to any one of claims 1 to 4, characterized in that: The following steps are involved: S1. Preparation of medicinal materials: Process and crush them according to the proportion to make them into fine powder; S2, demoulding: using a proper amount of adhesive to make part of the powder into fine particles and make a mold; S3, pan-pill: put the mold into the pan-pill pot, rotate and spray water or adhesive, and continuously add powder to make the mold gradually enlarge into water pills; S4, screening: use an appropriate sieve to screen the water pellets to remove pellets that are too large or too small; S5, drying: drying the screened water pills to remove moisture; S6. Packaging: Pack the dried product.
6. The method for preparing the water pill formula according to claim 5, characterized in that: In step S5, the diameter of the water pill is 3-5 mm.
7. The method for preparing the water pill formula according to claim 5, characterized in that: In step S5, the drying temperature is 40-50° C., the drying time is 2-3 hours, and the water content of the water pills is reduced to below 5%.
8. The method for preparing the water pill formula according to claim 5, characterized in that: In step S2, the diameter of the mold is 0.5-1 mm.