Multi-layer composite antibacterial medical packaging bag and preparation method thereof

Abstract

The invention relates to the field of medical packaging materials, in particular to a multi-layer composite antibacterial medical packaging bag and a preparation method thereof. The multi-layer composite antibacterial medical packaging bag is prepared from the following raw materials in parts by mass: 80 to 95 parts of antibacterial barrier resin composition, 25 to 40 parts of ethylene-vinyl alcohol copolymer composite composition and 60 to 70 parts of internally sealed polyethylene resin composition. The finally prepared multi-layer composite antibacterial medical packaging bag not only has excellent physical and mechanical properties, but also can maintain good chemical resistance and sealing performance while improving the overall antibacterial performance, overcomes the problem of material compatibility, greatly reduces the risks of damage, cracking and layering phenomena, and is suitable for large-scale popularization and application. Therefore, the comprehensive performance requirements of the existing medical field on the sealed medical packaging bag are met.

Description

Technical Field

[0001] This application relates to the field of medical packaging materials, and more specifically, to a multi-layer composite antibacterial medical packaging bag and its preparation method. Background Art

[0002] Medical packaging bags are mainly used for the aseptic packaging of medical equipment, drugs, and disposable medical devices. They are crucial for ensuring that medical products remain sterile before use, thereby preventing microbial contamination and safeguarding patient safety. Medical packaging bags generally need to meet a series of strict standards and requirements, including good physical properties (such as tear resistance, puncture resistance) and biocompatibility, etc.

[0003] With the development of medical technology, the requirements for medical packaging bags are also increasing day by day. For example, packaging materials used in some high-risk environments not only need to provide effective barrier protection to isolate bacteria and viruses in the external environment, but also need to have a certain degree of antibacterial ability to further reduce the risk of infection, as well as chemical stability to improve the quality of use in specific environments and sealing performance to ensure the avoidance of contamination leakage. For this reason, various types of medical packaging materials have emerged on the market, and among them, multi-layer composite structures have received extensive attention due to their excellent comprehensive performance.

[0004] Multi-layer composite medical packaging bags achieve high performance that cannot be achieved by single materials by combining the advantages of different materials. Common multi-layer structures include the combination of polymer films such as polyethylene (PE), polypropylene (PP), polyester (PET), etc. with aluminum foil or other materials with high barrier performance. However, although the multi-layer composite medical packaging bags under the existing technology show superior performance in many aspects, there are still some technical challenges and unsolved problems. For example: the antibacterial effect of the multi-layer structure is limited, and the cost of adding an antibacterial layer alone is relatively high; material compatibility problems, performance differences, adhesion, and compatibility problems between different materials will lead to the occurrence of breakage, cracking, and delamination phenomena, thus significantly affecting the mechanical, chemical resistance, and sealing performance of packaging materials.

[0005] Therefore, due to the emergence of the above technical problems, this application provides a multi-layer composite antibacterial medical packaging bag and its preparation method. The finally prepared multi-layer composite antibacterial medical packaging bag of this application can not only have excellent physical and mechanical properties, but also improve the overall antibacterial performance while maintaining good chemical resistance and sealing performance, overcome material compatibility problems, and significantly reduce the risk of breakage, cracking, and delamination phenomena, so as to meet the comprehensive performance requirements of the existing medical field for sealed medical packaging bags. Summary of the Invention

[0006] Multilayer composite antibacterial medical packaging bag, by mass, the raw materials include: 80 - 95 parts of antibacterial barrier resin composition, 25 - 40 parts of ethylene-vinyl alcohol copolymer composite composition, and 60 - 70 parts of inner-sealed polyethylene resin composition.

[0007] As a preferred embodiment, the antibacterial barrier resin composition includes: antibacterial barrier matrix resin, compounded functional additives, ultraviolet absorber, and defoamer.

[0008] As a preferred embodiment, the mass ratio of the antibacterial barrier matrix resin, compounded functional additives, ultraviolet absorber, and defoamer is (65 - 75):(6 - 12):(0.5 - 0.8):(0.2 - 0.4).

[0009] As a preferred embodiment, the mass ratio of the antibacterial barrier matrix resin, compounded functional additives, ultraviolet absorber, and defoamer is (70 - 75):(8 - 10):(0.5 - 0.6):(0.2 - 0.3).

[0010] As a preferred embodiment, the preparation method of the antibacterial barrier matrix resin specifically includes the following steps: S1: Dissolve ethylene-tetrafluoroethylene copolymer in hexafluoroisopropanol, stir at 60 - 70 °C for 3 - 4 h, then add 2,3,4-trifluorostyrene, 1-vinyl-3-hexylimidazolium bis(trifluoromethanesulfonyl)imide, and 4-vinylbenzocyclobutenone, and ultrasonically disperse under nitrogen protection for 30 - 40 min; S2: After adding azobisisobutyronitrile, raise the temperature to 85 - 95 °C and reflux for 10 - 12 h, controlling the pressure at 0.3 - 0.4 MPa; S3: Cool the reaction solution and inject it into methanol for precipitation, filter, and vacuum dry at 80 - 90 °C for 6 - 8 h to obtain the product after completion.

[0011] As a preferred embodiment, the mass ratio of the ethylene-tetrafluoroethylene copolymer, 2,3,4-trifluorostyrene, 1-vinyl-3-hexylimidazolium bis(trifluoromethanesulfonyl)imide, and 4-vinylbenzocyclobutenone is (75 - 85):(10 - 12):(6 - 8):(4 - 5).

[0012] As a preferred embodiment, the mass ratio of the ethylene-tetrafluoroethylene copolymer, 2,3,4-trifluorostyrene, 1-vinyl-3-hexylimidazolium bis(trifluoromethanesulfonyl)imide, and 4-vinylbenzocyclobutenone is 80:11:7:5.

[0013] By adding the above antibacterial barrier matrix resin, the physical and mechanical properties and overall antibacterial properties of the medical packaging bag can be effectively improved, while maintaining good chemical resistance and sealing properties. The modified ethylene-tetrafluoroethylene copolymer, as the outer layer material of the multi-layer composite antibacterial medical packaging bag, has significantly improved comprehensive properties through fluorinated monomer graft copolymerization and functional synergistic design. By releasing cations from ionic liquid monomers to disrupt the microbial cell membrane (charge adsorption-membrane perforation mechanism), the colonization of bacteria (such as MRSA) and fungi (such as Candida albicans) is inhibited; then, a dense and defect-free molecular sieve structure is formed through a fluorinated cross-linked network to block the penetration of oxygen, water vapor, and organic solvents. The surface energy is reduced by fluorinated groups to inhibit biofilm attachment. The thermal cross-linking reaction of 4-vinylbenzocyclobutenone forms a three-dimensional network, reducing the free volume of the chain segments, significantly reducing the movement and diffusion efficiency of water vapor while improving the overall physical and mechanical properties, and at the same time, resisting the bond-breaking effect of light while forming a fluorine protection layer. On the other hand, the presence of the fluorine protection layer enhances the interfacial interaction and interfacial strength while shielding the water molecule penetration path, thereby assisting in improving the overall mechanical properties and chemical resistance of the packaging bag material.

[0014] As a preferred embodiment, the compound functional auxiliary is a composition of polyhexamethylene biguanide hydrochloride, polyvinylidene chloride, and boron nitride.

[0015] As a preferred embodiment, the mass ratio of polyhexamethylene biguanide hydrochloride, polyvinylidene chloride-trifluoroethyl maleate copolymer, and boron nitride is (14-17):(8-10):(3-5).

[0016] As a preferred embodiment, the weight-average molecular weight of polyhexamethylene biguanide hydrochloride is 3000-5000 Da.

[0017] As a preferred embodiment, the ultraviolet absorber is at least one of benzotriazoles, benzophenone, cyanoacrylate, and polybutylene succinate.

[0018] As a preferred embodiment, the ultraviolet absorber is benzotriazoles.

[0019] As a preferred embodiment, the defoamer is at least one of polydimethylsiloxane, acetylenic diols, acrylates, and tributyl phosphate.

[0020] As a preferred embodiment, the defoamer is polydimethylsiloxane.

[0021] As a preferred embodiment, the ethylene-vinyl alcohol copolymer composite composition includes: ethylene-vinyl alcohol copolymer, filler, antioxidant, and dispersant.

[0022] As a preferred embodiment, the mass ratio of the ethylene-vinyl alcohol copolymer, the filler, the antioxidant and the dispersant is (15 to 25):(3 to 6):(0.3 to 0.5):(1 to 2).

[0023] As a preferred embodiment, the mass ratio of the ethylene-vinyl alcohol copolymer, the filler, the antioxidant and the dispersant is (18 to 22):(4 to 5):(0.3 to 0.4):(1.2 to 1.6).

[0024] As a preferred embodiment, the ethylene content of the ethylene-vinyl alcohol copolymer is 30 to 35 mol%.

[0025] As a preferred embodiment, the filler is precipitated barium sulfate.

[0026] As a preferred embodiment, the D50 average particle size of the precipitated barium sulfate is 0.5 to 1 μm.

[0027] As a preferred embodiment, the antioxidant is at least one of antioxidant 1010, antioxidant 1076 and antioxidant 168.

[0028] As a preferred embodiment, the antioxidant is antioxidant 168.

[0029] As a preferred embodiment, the dispersant is at least one of polyether-modified silicone, hyperbranched polyesteramine, phosphate ester salt and oxidized polyethylene wax.

[0030] As a preferred embodiment, the dispersant is oxidized polyethylene wax.

[0031] As a preferred embodiment, the inner-sealed polyethylene resin composition comprises: linear low-density polyethylene, a lubricant and a film-forming aid.

[0032] As a preferred embodiment, the mass ratio of the linear low-density polyethylene, the lubricant and the film-forming aid is (55 to 65):(0.3 to 0.5):(0.2 to 0.4).

[0033] As a preferred embodiment, the lubricant is at least one of fluorinated wax, calcium stearate, polyethylene wax and ethylene bisstearamide.

[0034] As a preferred embodiment, the lubricant is ethylene bisstearamide.

[0035] As a preferred embodiment, the film-forming aid is at least one of propylene glycol phenyl ether, liquid polybutadiene, aliphatic polycarbonate and polyethersulfone.

[0036] As a preferred embodiment, the film-forming aid is propylene glycol phenyl ether.

[0037] Preparation method of multi-layer composite antibacterial medical packaging bag, specifically including the following steps: S1: Premix the raw materials required for the antibacterial barrier resin composition, and melt and plasticize them with a single-screw extruder at a temperature range of 220-240°C; S2: Blend the raw materials required for the ethylene-vinyl alcohol copolymer composite composition, coat them with a casting machine, the die head temperature is 200-210°C, and the cooling roll temperature is 25-30°C; S3: Knead the inner-sealed polyethylene resin composition at 160-170°C for 12-15 minutes with a kneader, and calender it into a film; S4: Extrude with a three-layer co-extrusion die head, divided into an outer layer, a middle layer and an inner layer, the temperature gradient is 220-240°C for the outer layer, 210-215°C for the middle layer, and 180-190°C for the inner layer. After the composite film is biaxially stretched, it is wound up, and finally irradiated and crosslinked by electron beam with a dose of 10-12 kGy. After completion, it is slit and made into bags by hot air to obtain the product.

[0038] As a preferred embodiment, the outer layer is formed by the antibacterial barrier resin composition, and its thickness is 30-40 μm.

[0039] As a preferred embodiment, the middle layer is formed by the ethylene-vinyl alcohol copolymer composite composition, and its thickness is 20-25 μm.

[0040] As a preferred embodiment, the inner layer is formed by the inner-sealed polyethylene resin composition, and its thickness is 35-45 μm.

[0041] The beneficial effects of this application are:

[0042] 1. A multi-layer composite antibacterial medical packaging bag provided in this application not only has excellent physical and mechanical properties, but also can improve the overall antibacterial performance while maintaining good chemical resistance and sealing performance, overcome the material compatibility problem, and greatly reduce the risk of breakage, cracking and delamination, so as to meet the comprehensive performance requirements of the existing medical field for sealed medical packaging bags.

[0043] 2. A multi-layer composite antibacterial medical packaging bag provided in the present application uses a modified ethylene-tetrafluoroethylene copolymer as the outer layer material of the multi-layer composite antibacterial medical packaging bag. Through graft copolymerization of fluorine-containing monomers and functional synergistic design, the comprehensive performance is greatly improved. Cationic ions are released through ionic liquid monomers to destroy the cell membranes of microorganisms and inhibit the colonization of bacteria and fungi; then a dense and defect-free molecular sieve structure is formed through a fluorinated crosslinked network to block the penetration of oxygen, water vapor and organic solvents. The surface energy is reduced by fluorine-containing groups to inhibit the attachment of biofilms. The thermal crosslinking reaction of 4-vinylbenzocyclobutenone forms a three-dimensional network, reducing the free volume of the chain segments, greatly reducing the movement and diffusion efficiency of water vapor while improving the overall physical and mechanical properties. On the other hand, the presence of the fluorine protection layer shields the water molecule penetration path while enhancing the interfacial interaction and interfacial strength, thereby assisting in improving the overall mechanical properties and chemical resistance of the packaging bag material.

[0044] 3. A multi-layer composite antibacterial medical packaging bag provided in the present application, through the combined action of compounding functional aids and the antibacterial barrier matrix resin of the main outer layer raw materials, can further improve the instantaneous sterilization efficiency while increasing the density of the crosslinked network inside the system through chain segment interaction, thereby greatly increasing the water vapor barrier resistance and reducing the diffusion path. And through the good connection between solid particles and the resin, the internal micropore porosity is reduced, and thus the overall performance of the medical packaging bag is assisted in improving. Specific Embodiments

[0045] In the specific embodiments, specific implementation cases will be used to more intuitively display and explain the content in the inventive content of the present application. And the following embodiments are only actual examples for illustrating and explaining the content of the technical solutions in the specification, and should not limit the scope of the claims to be protected by the present application.

[0046] Example 1

[0047] For the multi-layer composite antibacterial medical packaging bag, calculated by mass parts, the raw materials include: 85.8 parts of antibacterial barrier resin composition, 27 parts of ethylene-vinyl alcohol copolymer composite composition, and 60.5 parts of inner-sealed polyethylene resin composition.

[0048] The antibacterial barrier resin composition includes: antibacterial barrier matrix resin, compounded functional aids, ultraviolet absorber and defoamer, and the mass ratio is 75:10:0.5:0.3.

[0049] The ethylene-vinyl alcohol copolymer composite composition includes: ethylene-vinyl alcohol copolymer, filler, antioxidant and dispersant, and the mass ratio is 20.5:4.6:0.4:1.5.

[0050] The inner-sealed polyethylene resin composition includes: linear low-density polyethylene, lubricant and film-forming aid, and the mass ratio is 60:0.3:0.2.

[0051] A preparation method of an antibacterial barrier matrix resin, in parts by mass, specifically includes the following steps: S1: Dissolve 80 parts of ethylene-tetrafluoroethylene copolymer in 200 parts of hexafluoroisopropanol, stir at 70 °C for 4 h, then add 11 parts of 2,3,4-trifluorostyrene, 7 parts of 1-vinyl-3-hexylimidazolium bis(trifluoromethylsulfonyl)imide and 5 parts of 4-vinylbenzocyclobutenone, and ultrasonically disperse for 35 min under nitrogen protection; S2: Add 0.4 part of azobisisobutyronitrile and then heat up to 90 °C for reflux reaction for 11 h, controlling the pressure at 0.3 MPa; S3: After the reaction solution is cooled, inject it into methanol for precipitation, filter and then dry in vacuum at 85 °C for 8 h to obtain the product after completion.

[0052] The ethylene-tetrafluoroethylene copolymer is purchased from the product of model HT-2164 sold by DuPont Company in the United States. HT-2164

[0053] The compound functional additive is a composition of polyhexamethylene biguanide hydrochloride, polyvinylidene chloride and boron nitride, and the mass ratio is 15:9.5:4.

[0054] The weight-average molecular weight of polyhexamethylene biguanide hydrochloride is 4000 Da, and it is purchased from the corresponding molecular weight product sold by Dixin Chemical Co., Ltd. in Zhongshan City, China.

[0055] The ultraviolet absorber is benzotriazole 326.

[0056] The defoaming agent is polydimethylsiloxane BYK-022.

[0057] The ethylene content of the ethylene-vinyl alcohol copolymer is 32 mol%, and it is purchased from the product of model DC3203 sold by Synthetic Chemical Co., Ltd. in Japan. DC3203

[0058] The filler is precipitated barium sulfate, the average D50 particle size is 0.8 μm; the antioxidant is antioxidant 168; the dispersant is oxidized polyethylene wax, and it is purchased from the product of model AC-617A sold by Honeywell Company in the United States.

[0059] The lubricant is ethylene bisstearamide; the film-forming aid is propylene glycol phenyl ether.

[0060] Preparation method of multi-layer composite antibacterial medical packaging bag, specifically including the following steps: S1: Premix the raw materials required for the antibacterial barrier resin composition, melt and plasticize through a single-screw extruder, with the temperature range of 220-240 °C; S2: Blend the raw materials required for the ethylene-vinyl alcohol copolymer composite composition, coat through a casting machine, with the die head temperature of 200 °C and the cooling roll temperature of 25 °C; S3: Knead the inner-sealed polyethylene resin composition at 160 °C for 14 min in a kneader and roll it into a film; S4: Extrude using a three-layer co-extrusion die head, divided into an outer layer, a middle layer and an inner layer, with the temperature gradient of 230 °C for the outer layer, 210 °C for the middle layer and 190 °C for the inner layer. The composite film is biaxially stretched and then wound up, and finally irradiated and crosslinked by electron beam with a dose of 10 kGy. After completion, it is slit and made into bags by hot air, thus obtaining the product.

[0061] The outer layer is formed by the antibacterial barrier resin composition, with a thickness of 35 μm; the middle layer is formed by the ethylene-vinyl alcohol copolymer composite composition, with a thickness of 20 μm; the inner layer is formed by the inner-sealed polyethylene resin composition, with a thickness of 40 μm.

[0062] Example 2

[0063] This example is only different from Example 1 in the following aspects: For the multi-layer composite antibacterial medical packaging bag, by mass, the raw materials include: 85.8 parts of antibacterial barrier resin composition, 27 parts of ethylene-vinyl alcohol copolymer composite composition, and 65.5 parts of inner-sealed polyethylene resin composition.

[0064] The antibacterial barrier resin composition includes: antibacterial barrier matrix resin, compound functional additives, ultraviolet absorber and defoamer, with the mass ratio of 73:12:0.6:0.2.

[0065] The ethylene-vinyl alcohol copolymer composite composition includes: ethylene-vinyl alcohol copolymer, filler, antioxidant and dispersant, with the mass ratio of 20:4.5:0.5:2.

[0066] The inner-sealed polyethylene resin composition includes: linear low-density polyethylene, lubricant and film-forming aid, with the mass ratio of 65:0.3:0.2.

[0067] Example 3

[0068] This example is only different from Example 1 in the following aspects: For the multi-layer composite antibacterial medical packaging bag, by mass, the raw materials include: 72 parts of antibacterial barrier resin composition, 27 parts of ethylene-vinyl alcohol copolymer composite composition, and 60.5 parts of inner-sealed polyethylene resin composition.

[0069] The antibacterial barrier resin composition includes: antibacterial barrier matrix resin, compound functional additives, ultraviolet absorber and defoamer, with the mass ratio of 65:6:0.6:0.4.

[0070] Comparative Example 1

[0071] This comparative example is only different from Example 1 in the following aspects: for the multi-layer composite antibacterial medical packaging bag, calculated by mass parts, the raw materials include: 73.8 parts of antibacterial barrier resin composition, 27 parts of ethylene-vinyl alcohol copolymer composite composition, and 60.5 parts of inner-sealed polyethylene resin composition.

[0072] The antibacterial barrier resin composition includes: antibacterial barrier matrix resin, compound functional additives, ultraviolet absorber and defoamer, and the mass ratio is 70:3:0.5:0.3.

[0073] Comparative Example 2

[0074] This comparative example is only different from Example 1 in the following aspects: the antibacterial barrier resin composition includes: antibacterial barrier matrix resin, compound functional additives, ultraviolet absorber and defoamer, and the mass ratio is 65:20:0.5:0.3.

[0075] Comparative Example 3

[0076] This comparative example is only different from Example 1 in the following aspects: the preparation method of the antibacterial barrier matrix resin, calculated by mass parts, specifically includes the following steps: S1: Dissolve 80 parts of ethylene-tetrafluoroethylene copolymer in 200 parts of hexafluoroisopropanol, stir at 70 °C for 4 h, then add 18 parts of 2,3,4-trifluorostyrene, 3.5 parts of 1-vinyl-3-hexylimidazolium bis(trifluoromethylsulfonyl)imide, and 2.2 parts of 4-vinylbenzocyclobutenone, and ultrasonically disperse for 35 min under nitrogen protection; S2: Add 0.4 part of azobisisobutyronitrile and then raise the temperature to 90 °C for reflux reaction for 11 h, controlling the pressure at 0.3 MPa; S3: After the reaction solution is cooled, inject it into methanol for precipitation, filter, and vacuum dry at 85 °C for 8 h to obtain the product after completion.

[0077] Comparative Example 4

[0078] This comparative example is only different from Example 1 in the following aspects: the preparation method of the antibacterial barrier matrix resin, calculated by mass parts, specifically includes the following steps: S1: Dissolve 80 parts of ethylene-tetrafluoroethylene copolymer in 200 parts of hexafluoroisopropanol, stir at 70 °C for 4 h, then add 5.5 parts of 2,3,4-trifluorostyrene, 10 parts of 1-vinyl-3-hexylimidazolium bis(trifluoromethylsulfonyl)imide, and 2.5 parts of 4-vinylbenzocyclobutenone, and ultrasonically disperse for 35 min under nitrogen protection; S2: Add 0.4 part of azobisisobutyronitrile and then raise the temperature to 90 °C for reflux reaction for 11 h, controlling the pressure at 0.3 MPa; S3: After the reaction solution is cooled, inject it into methanol for precipitation, filter, and vacuum dry at 85 °C for 8 h to obtain the product after completion.

[0079] Comparative Example 5

[0080] This comparative example and Example 1 only differ in the following aspects: the compound functional auxiliary is a composition of polyhexamethylene biguanide hydrochloride, polyvinylidene chloride and boron nitride, with a mass ratio of 15:3.5:1.5.

[0081] Comparative Example 6

[0082] This comparative example and Example 1 only differ in the following aspects: the antibacterial barrier matrix resin is ethylene-tetrafluoroethylene copolymer.

[0083] Performance Evaluation

[0084] 1. Refer to the standard ISO 22196:2011 to conduct antibacterial tests on the medical packaging bags prepared in the examples and comparative examples. The test samples are subjected to 28-day accelerated aging, and the antibacterial test object is Escherichia coli. The results of 10 tests are averaged and recorded in Table 1.

[0085] 2. Refer to the standard ASTM D1922 to conduct tear resistance tests on the medical packaging bags prepared in the examples and comparative examples. The results of 10 tests of the transverse tear strength are averaged and recorded in Table 1.

[0086] 3. Refer to the standard ASTM D1922 to conduct chemical resistance tests on the medical packaging bags prepared in the examples and comparative examples. The corrosive medium is 5wt% sodium hypochlorite solution. The tensile strength of the samples is obtained by a universal tensile machine before and after the test, and the retention rate of the tensile strength is obtained. The results of 10 tests are averaged and recorded in Table 1.

[0087] 4. Refer to the standard ASTM E96 / E96M to conduct water vapor transmission rate tests on the medical packaging bags prepared in the examples and comparative examples. The results of 10 tests are averaged and recorded in Table 1.

[0088] Table 1 Performance Test Results

[0089]

[0090]

[0091] From the final performance test results of the examples and comparative examples, Comparative Examples 1-6 obtained worse performance results compared to the examples. While the examples, through a better technical solution, can further improve the instantaneous sterilization efficiency through the combined action of the antibacterial barrier matrix resin and the compound functional auxiliary, and at the same time increase the density of the internal cross-linked network of the system through the interaction of chain segments, thereby greatly increasing the barrier resistance to water vapor and reducing the diffusion path. And through the good connection between solid particles and the resin, the internal micropore porosity is reduced, and thus the overall performance of the medical packaging bag is assisted to improve.

Claims

1. A multi-layer composite antibacterial medical packaging bag, characterized in that: The raw materials include, by mass: 80 to 95 parts of an antibacterial barrier resin composition, 25 to 40 parts of an ethylene-vinyl alcohol copolymer composite composition, and 60 to 70 parts of an inner sealing polyethylene resin composition; The antibacterial barrier resin composition comprises: an antibacterial barrier matrix resin, a compound functional auxiliary agent, an ultraviolet absorber and a defoamer, with a mass ratio of (65-75): (6-12): (0.5-0.8): (0.2-0.4); The composite functional additive is a composition of polyhexamethylene biguanide hydrochloride, polyvinylidene chloride-trifluoroethyl maleate copolymer and boron nitride, with a mass ratio of (14-17): (8-10): (3-5); The ethylene-vinyl alcohol copolymer composite composition comprises: ethylene-vinyl alcohol copolymer, filler, antioxidant and dispersant, with a mass ratio of (15-25): (3-6): (0.3-0.5): (1-2); The inner sealing polyethylene resin composition comprises: linear low-density polyethylene, lubricant and film-forming aid, and the mass ratio is (55-65): (0.3-0.5): (0.2-0.4).

2. The multi-layer composite antibacterial medical packaging bag according to claim 1, characterized in that: The preparation method of the antibacterial barrier matrix resin specifically includes the following steps: S1: dissolving ethylene-tetrafluoroethylene copolymer in hexafluoroisopropanol, stirring at 60-70° C. for 3-4 hours, then adding 2,3,4-trifluorostyrene, 1-vinyl-3-hexylimidazole bistrifluoromethanesulfonyl imide salt and 4-vinylbenzocyclobutenone, and ultrasonically dispersing for 30-40 minutes under nitrogen protection; S2: adding azobisisobutyronitrile, heating to 85-95° C., reflux reaction for 10-12 hours, and controlling the pressure to 0.3-0.4 MPa; S3: cooling the reaction solution, injecting it into methanol for precipitation, filtering, and vacuum drying at 80-90° C. for 6-8 hours to obtain the antibacterial barrier matrix resin.

3. The multi-layer composite antibacterial medical packaging bag according to claim 2, characterized in that: The mass ratio of the ethylene-tetrafluoroethylene copolymer, 2,3,4-trifluorostyrene, 1-vinyl-3-hexyl imidazole bistrifluoromethanesulfonyl imide salt and 4-vinylbenzocyclobutenone is (75-85): (10-12): (6-8): (4-5).

4. The multi-layer composite antibacterial medical packaging bag according to claim 3, characterized in that: The weight average molecular weight of the polyhexamethylene biguanide hydrochloride is 3000-5000 Da.

5. The multi-layer composite antibacterial medical packaging bag according to claim 4, characterized in that: The ethylene content of the ethylene-vinyl alcohol copolymer is 30 to 35 mol%.

6. The multi-layer composite antibacterial medical packaging bag according to claim 5, characterized in that: The filler is precipitated barium sulfate; the D50 average particle size of the precipitated barium sulfate is 0.5-1 μm.

7. The multi-layer composite antibacterial medical packaging bag according to claim 6, characterized in that: The dispersant is at least one of polyether modified siloxane, hyperbranched polyester amine, phosphate ester salt and oxidized polyethylene wax.

8. The multi-layer composite antibacterial medical packaging bag according to claim 7, characterized in that: The lubricant is at least one of fluorinated wax, calcium stearate, polyethylene wax and ethylene bisstearamide.

9. The multi-layer composite antibacterial medical packaging bag according to claim 8, characterized in that: The film-forming aid is at least one of propylene glycol phenyl ether, liquid polybutadiene, aliphatic polycarbonate and polyether sulfone.

10. A method for preparing the multi-layer composite antibacterial medical packaging bag according to any one of claims 1 to 9, characterized in that: The specific steps include: S1: premixing the raw materials required for the antibacterial barrier resin composition, and melting and plasticizing through a single screw extruder at a temperature range of 220-240°C; S2: blending the raw materials required for the ethylene-vinyl alcohol copolymer composite composition, coating it through a casting machine, with a die head temperature of 200-210° C. and a cooling roller temperature of 25-30° C.; S3: The inner sealing polyethylene resin composition is mixed in an internal mixer at 160-170°C for 12-15min, and calendered into a film; S4: a three-layer co-extrusion die is used for extrusion, which is divided into an outer layer, a middle layer and an inner layer, and the temperature gradient is 220-240°C for the outer layer, 210-215°C for the middle layer, and 180-190°C for the inner layer. The composite film is rolled up after biaxial stretching, and finally cross-linked by electron beam irradiation with a dosage of 10-12kGy. After completion, it is cut into hot air bags to obtain the composite film.

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