FPGA-based intelligent microfluidic chemical reaction platform

Abstract

The application discloses an intelligent micro-fluidic chemical reaction platform based on FPGA, which comprises an FPGA core control board, a user service module, a video coding module, an industrial control board and a micro-fluidic reaction equipment unit, wherein the user service module, the video coding module and the industrial control board are controlled by the FPGA core control board, the chemical reaction equipment unit is intelligently and accurately controlled, the micro-fluidic chemical reaction is carried out according to the user demand, and the teaching demonstration function is considered, the control and monitoring of multiple reaction parameters such as temperature, pressure, mass and pH are integrated, the intelligent micro-fluidic reaction integrated control is realized, two image sensors are used to monitor the experiment process in real time and store the video of the reaction process in the reaction chip, and the complete saving of reaction data is ensured. The application has the advantages of reasonable structure, high working freedom, convenient control, good compatibility and strong interactive ability, and is suitable for various scenes such as classroom experiment teaching, student exploration experiment and college laboratory scientific research.

Description

TECHNICAL FIELD

[0001] The present application relates to the fields of continuous flow chemistry technology, network communication technology, high-speed electronic circuit technology, and in particular to an intelligent microfluidic chemical reaction platform based on FPGA, which is suitable for automatic control of reaction conditions in flow chemistry experiments, and collection, transmission and analysis of experimental data and video data. BACKGROUND

[0002] Continuous flow chemistry refers to a chemical reaction device and method in which two or more different reactants are pumped into a single chamber, pipe or microreactor at a specific flow rate. After the reaction is completed, the stream containing the resulting compound is collected at the outlet, or it is directed to a subsequent flow reactor circuit for further reaction to obtain the final product. Network communication technology refers to the technology of collecting, storing, processing and transmitting data through a computer network system, so as to realize the full sharing of information resources. Flow chemistry has been widely used in many fields such as pharmaceuticals and fine chemicals, but the popularization of the concept of flow chemistry in the field of chemical education has not kept up, and traditional batch reaction methods are still used for experiments, with low system integration. Considering the growing demand for efficient, safe and green chemistry in chemical research and industrial production, it is particularly important to introduce flow chemistry knowledge into experimental teaching, combine continuous flow chemistry technology with network communication technology and high-speed electronic circuit technology, and design an intelligent microfluidic chemical reaction platform with rich functions, convenient operation and superior performance.

[0003] The key points that need to be solved in the flow chemistry experiment platform are: first, to build a highly versatile and easy-to-operate system, which can be compatible with multiple reactants, reaction types and reaction conditions through replaceable module design, to ensure easy and efficient switching between different experiments, and to meet the needs of demonstration and exploration of various reaction types in teaching; second, to ensure the coordinated improvement of automation and safety, to accurately set and adjust reaction parameters, to real-time feedback of reaction progress and result data, to monitor real-time dynamics during the reaction platform experiment, and to store reaction phenomenon videos for easy understanding of reaction principles and influencing factors by students, and timely review of past experiments. Moreover, multiple safety monitoring and protection mechanisms are embedded to ensure safe and reliable operation of the experiment process without direct monitoring; third, to design a controller with high functional expandability. An open programming interface and modular functional architecture are built to facilitate the addition of new control algorithms, data processing functions and connection with other devices for post-processing, laying a foundation for cultivating talents to meet the needs of modern chemical development. SUMMARY

[0004] The application aims at providing an intelligent microfluidic chemical reaction platform based on FPGA to solve the problems in the prior art, which integrates a FPGA core control board, a user service module, a video coding module, an industrial control board and a flow chemistry equipment module, receives control instructions sent by the user service module through the optical fiber Ethernet communication module of the FPGA core control board, and accurately transmits the instructions to the industrial control board and the video coding module, so as to realize accurate control of the flow chemistry equipment module and real-time collection and storage of experimental video data; the experimental personnel can accurately control each component of the whole reaction platform through the user service module, quantitatively adjust each experimental parameter of the flow chemistry reaction system, monitor the real-time dynamics of the reaction platform, and call past experimental videos for comparative study; the application has the advantages of reasonable structure, high working freedom, convenient control, good compatibility and strong interactive ability.

[0005] The specific technical scheme for realizing the application is:

[0006] An intelligent microfluidic chemical reaction platform based on FPGA, which comprises a FPGA core control board, a user service module, a video coding module, an industrial control board and a flow chemistry equipment module.

[0007] The FPGA core control board is connected with the user service module, the video coding module, the industrial control board and the flow chemistry equipment module, and is used to receive and analyze instruction data sent by the user service module, upload experimental data collected by the industrial control board in the reaction process of the flow chemistry equipment module, and receive the encoded experimental monitoring video of the flow chemistry equipment module output by the video coding module.

[0008] The user service module is connected with the FPGA core control board, and is used to receive experimental data and monitoring video sent by the FPGA core control board, and send user operation instructions to the FPGA core control board.

[0009] The video coding module is connected with the FPGA core control board and the flow chemistry equipment module, and is used to obtain monitoring video in the experimental process of the flow chemistry equipment module, encode the video by H.265, and then transmit the video to the FPGA core control board for storage.

[0010] The industrial control board is connected with the FPGA core control board and the flow chemistry equipment module, and is used to receive control instructions sent by the FPGA core control board, collect the values of each experimental parameter in the reaction process of the flow chemistry equipment module, and transmit the values to the FPGA core control board for processing.

[0011] The flow chemistry equipment module is connected with the FPGA core control board and the industrial control board, so as to receive the control signal sent by the industrial control board and accurately execute, and the reaction process image is collected by the FPGA core control board in real time.

[0012] The FPGA core control board comprises a clock module, a power supply module, a fiber optical Ethernet communication module, a MIPI image sensor module, a microfluidic chemical reaction control module, a video storage module, a video output module, a data cache module and a gigabit Ethernet communication module.

[0013] The clock module is connected with the power supply module, the fiber optical Ethernet communication module, the video monitoring module, the microfluidic chemical reaction control module, the video storage module, the video output module, the data cache module and the gigabit Ethernet communication module, and provides a reference clock for each module.

[0014] The power supply module is connected with the clock module, the fiber optical Ethernet communication module, the MIPI image sensor module, the microfluidic chemical reaction control module, the video storage module, the video output module, the data cache module and the gigabit Ethernet communication module, and supplies power for each module.

[0015] The fiber optical Ethernet communication module comprises a fiber optical Ethernet data receiving module and a fiber optical Ethernet data sending module, and is connected with the clock module, the power supply module, the microfluidic chemical reaction control module, the video output module, the gigabit Ethernet communication module and the user service module; the fiber optical Ethernet data receiving module receives the operation instruction sent by the user service module, and transmits the operation instruction to the gigabit Ethernet communication module and the microfluidic chemical reaction control module; the fiber optical Ethernet data sending module receives the video signal output by the video output module, the judgment result of various experimental data collected by the microfluidic chemical reaction control module on the experimental progress, and sends the above data in the form of a TCP data packet to the user service module.

[0016] The video monitoring module comprises a MIPI interface module and an image sensor module, and is connected with the clock module, the power supply module, the flow chemistry equipment module and the video output module; the image sensor module collects the picture in the experimental process of the flow chemistry equipment module in real time, and transmits the picture to the video output module through the MIPI interface module to be output and displayed, so as to be used for observation and demonstration in the experimental process.

[0017] The microfluidic chemical reaction control module includes a reaction progress judgment module, a real-time parameter acquisition module, a power-on system state detection module and a control signal generation module, and is connected with a clock module, a power module, an optical fiber Ethernet data receiving module, an optical fiber Ethernet data sending module and an industrial control board; the reaction progress judgment module judges the progress of the reaction according to the experimental process parameters collected by the real-time parameter acquisition module, and transmits the result to the optical fiber Ethernet data sending module; the real-time parameter acquisition module directly transmits the collected experimental process parameters to the optical fiber Ethernet data sending module; the power-on system state detection module generates initialization check instructions of each component of the flow chemistry equipment module when the system is powered on, and generates corresponding control signals through the control signal generation module to check the state of the initially powered system and ensure the normal function of each component.

[0018] The video storage module includes a SATA hard disk module and a SATA interface module, and is connected with a clock module, a power module, a video output module and a data buffer module; the SATA interface module receives the encoded reaction video data transmitted by the data buffer module, and stores the data in the SATA hard disk module; at the same time, the stored reaction video data is sent to the video output module for decoding and outputting.

[0019] The video output module includes an H.265 video decoding module and an HDMI interface module, and is connected with a clock module, a power module, an optical fiber Ethernet sending module, an MIPI interface module and a SATA interface module; the module allows receiving the uncoded real-time monitoring video data transmitted by the MIPI interface module and outputting the data through the HDMI interface module; the module can also receive the reaction video data stored in the SATA hard disk module and transmitted by the SATA interface module, and transmit the decoded data to the HDMI interface module or the optical fiber Ethernet data sending module after decoding by the H.265 video decoding module.

[0020] The data buffer module includes a DDR4 data buffer module and a DDR4 data control module, and is connected with a clock module, a power module, a SATA interface module and a gigabit Ethernet communication module; the DDR4 data buffer module performs real-time high-speed caching on the encoded reaction video data transmitted by the gigabit Ethernet communication module; and the DDR4 data control module transmits the real-time cached data to the SATA interface module according to the timing requirements of the SATA interface.

[0021] The gigabit Ethernet communication module includes a gigabit Ethernet sending module and a gigabit Ethernet receiving module, which are connected with a clock module, a power module, a fiber Ethernet data receiving module, an H.265 video encoding module and a DDR4 data cache module; the gigabit Ethernet sending module receives user instructions forwarded by the fiber Ethernet data receiving module and sends them to the H.265 video encoding module; the gigabit Ethernet receiving module receives encoded reaction video data transmitted by the H.265 video encoding module and sends them to the DDR4 data cache module for real-time high-speed caching.

[0022] The user service module includes a user operation interface and a user data storage module.

[0023] The user operation interface is connected with the fiber Ethernet data receiving module and the user data storage module, used to generate user operation instructions and send them to the fiber Ethernet data receiving module, read reaction parameters and video data from the user data storage module and display, and strengthen user interaction.

[0024] The data storage module is connected with the fiber Ethernet data sending module, used to receive and store reaction parameters and video data.

[0025] The video encoding module includes an image sensor module, an MIPI interface module and an H.265 video encoding module.

[0026] The image sensor module is connected with the MIPI interface module and the flow chemistry equipment module, used to collect reaction video data in real time and transmit them to the MIPI interface module.

[0027] The MIPI interface module is connected with the image sensor module and the H.265 video encoding module, used to transmit reaction video data collected by the image sensor module to the H.265 video encoding module.

[0028] The H.265 video encoding module is connected with the gigabit Ethernet receiving module and the MIPI interface module, used to receive uncoded reaction video data transmitted by the MIPI interface module and output them to the gigabit Ethernet receiving module after H.265 encoding.

[0029] The industrial control board includes an RS module, a PWM output module, a relay matrix module, an ADC sampling module and a motor driving module.

[0030] The RS module is connected with the real-time parameter collection module, the control signal generation module and the flow chemistry equipment module, used to receive control signals sent by the control signal generation module and accurately control relevant flow chemistry equipment, and transmit feedback parameters of relevant equipment to the real-time parameter collection module.

[0031] The PWM output module is connected with the control signal generation module and the flow chemistry equipment module, receives the control signal and generates corresponding PWM waves to realize control on the related equipment in the flow chemistry equipment module.

[0032] The relay matrix module is connected with the control signal generation module and the flow chemistry equipment module, receives the control signal and realizes switching operation on the relay matrix to control the related equipment in the flow chemistry equipment module.

[0033] The ADC sampling module is connected with the real-time parameter acquisition module, the control signal generation module and the flow chemistry equipment module, receives the control signal and realizes real-time sampling on each experimental parameter in the flow chemistry equipment module, and transmits the sampling data to the real-time parameter acquisition module.

[0034] The motor driving module is connected with the control signal generation module and the flow chemistry equipment module, receives the control signal and generates motor control signals to drive the motor in the flow chemistry equipment module to work accurately.

[0035] The beneficial effects of the present application are:

[0036] (1) The present application uses FPGA hardware architecture to process high-bandwidth network data and complex control instructions, and has higher processing speed and stronger parallel processing capability compared with the architecture of traditional ARM chips.

[0037] (2) The present application considers the control of each reaction parameter and experimental equipment in the flow chemistry reaction, and has complete system structure and high integration.

[0038] (3) The present application integrates a system power-on automatic detection module, which performs self-checking of each module in the whole system at initial power-on, to ensure safe and efficient experimental process.

[0039] (4) The present application encodes and stores the flow chemistry reaction video, which is convenient for subsequent comparative experimental learning, and has great significance for teaching and research.

[0040] (5) The present application establishes a complete database system to record experimental data in detail, and has strong data reliability and high completeness.

[0041] (6) The present application realizes integrated control of flow chemistry reaction in different demand scenarios, and has strong universality and strong compatibility. DETAILED DESCRIPTION

[0042] Figure 1 is the architecture diagram of the present application;

[0043] Figure 2 is the working flow chart of the present application;

[0044] Figure 3Flow chemistry equipment module workflow diagram for the present application in the experiment.

[0045] In the figure: 1-FPGA core control board; 2-user service module; 3-video encoding module; 4-industrial control board; 5-flow chemistry equipment module; 11-clock module; 12-power module; 13-fiber Ethernet communication module; 14-MIPI image sensor module; 15-microfluidic chemical reaction control module; 16-video storage module; 17-video output module; 18-data cache module; 19-gigabit Ethernet communication module; 21-user operation interface; 22-user data storage module; 31-image sensor module; 32-MIPI interface module; 33-H.265 video encoding module; 41-RS485 module; 42-PWM output module; 43-relay matrix module; 44-ADC sampling module; 45-motor drive module; 51-optoelectronic bubble sensor; 52-liquid storage bottle array; 53-vertical injection pump; 54-electromagnetic switching valve; 55-pressure sensor; 56-temperature control module; 57-flow chemistry reaction chip; 58-temperature sensor; 59-back pressure valve; 510-pH sensor; 511-product liquid storage bottle; 512-mass sensor; 513-waste liquid storage bottle; 131-fiber Ethernet data receiving module; 132-fiber Ethernet data sending module 132; 141-MIPI interface module; 142-image sensor module; 151-reaction progress judgment module; 152-real-time parameter acquisition module; 153-power-on system state detection module; 154-control signal generation module; 161-SATA hard disk module; 162-SATA interface module; 171-H.265 video decoding module; 172-HDMI interface module; 181-DDR4 data cache module; 182-DDR4 data control module; 191-gigabit Ethernet sending module; 192-gigabit Ethernet receiving module. DETAILED DESCRIPTION

[0046] The present application will be described in detail below with reference to the accompanying drawings and examples.

[0047] Reference Figure 1 , the embodiment includes FPGA core control board 1, user service module 2, video encoding module 3, industrial control board 4 and flow chemistry equipment module 5;

[0048] The FPGA core control board 1 is connected with the user service module 2, the video encoding module 3, the industrial control board 4 and the flow chemistry equipment module 5;

[0049] The user service module 2 is connected with the FPGA core control board 1;

[0050] The video coding module 3 is connected with the FPGA core control board 1 and the flow chemistry equipment module 5;

[0051] The industrial control board 4 is connected with the FPGA core control board 1 and the flow chemistry equipment module 5;

[0052] The flow chemistry equipment module 5 is connected with the FPGA core control board 1 and the industrial control board 4.

[0053] Referring to Figure 1The FPGA core control board 1 comprises a clock module 11, a power module 12, a fiber Ethernet communication module 13, a MIPI image sensor module 14, a microfluidic chemical reaction control module 15, a video storage module 16, a video output module 17, a data cache module 18 and a gigabit Ethernet communication module 19; the clock module 11 is connected with the power module 12, the fiber Ethernet communication module 13, the video monitoring module 14, the microfluidic chemical reaction control module 15, the video storage module 16, the video output module 17, the data cache module 18 and the gigabit Ethernet communication module 19, and provides a reference clock for each module; the power module 12 is connected with the clock module 11, the fiber Ethernet communication module 13, the MIPI image sensor module 14, the microfluidic chemical reaction control module 15, the video storage module 16, the video output module 17, the data cache module 18 and the gigabit Ethernet communication module 19, and supplies power for each module; the fiber Ethernet communication module 13 comprises a fiber Ethernet data receiving module 131 and a fiber Ethernet data sending module 132, is connected with the clock module 11, the power module 12, the microfluidic chemical reaction control module 15, the video output module 17, the gigabit Ethernet communication module 19 and the user service module 2, receives the operation instruction sent by the user service module 2 through the fiber Ethernet data receiving module 131, and transmits the operation instruction to the gigabit Ethernet communication module 19 and the microfluidic chemical reaction control module 15; the fiber Ethernet data sending module 132 receives the video signal output by the video output module 17, the judgment result of various experimental data collected by the microfluidic chemical reaction control module 15 on the experimental progress, and transmits the above data to the user service module 2 in the form of a TCP data packet; the video monitoring module 14 comprises a MIPI interface module 141 and an image sensor module 142, is connected with the clock module 11, the power module 12, the flow chemical equipment module 5 and the video output module 17, the image sensor module 142 collects pictures in the experimental process of the flow chemical equipment module 5 in real time and transmits them to the video output module 17 for output and display through the MIPI interface module 141, and is used for observation and demonstration in the experimental process; the microfluidic chemical reaction control module 15 comprises a reaction progress judgment module 151, a real-time parameter acquisition module 152, a power-on system state detection module 153 and a control signal generation module 154, is connected with the clock module 11, the power module 12, the fiber Ethernet data receiving module 131, the fiber Ethernet data sending module 132 and the industrial control board 4, the reaction progress judgment module 151 judges the progress of the reaction according to the experimental process parameters collected by the real-time parameter acquisition module 152, and transmits the result to the fiber Ethernet data sending module 132; the real-time parameter acquisition module 152 directly transmits the collected experimental process parameters to the fiber Ethernet data sending module 132.The power-on system state detection module 153 generates initialization check instructions for each component of the flow chemistry device module 5 when the system is powered on, and generates corresponding control signals through the control signal generation module 154 to perform state checking on the initially powered-on system to ensure that each component functions normally; the video storage module 16 includes a SATA hard disk module 161 and a SATA interface module 162, which are connected to the clock module 11, the power module 12, the video output module 17, and the data cache module 18; the SATA interface module 162 receives the encoded reaction video data transmitted by the data cache module 18 and stores it in the SATA hard disk module 161, while sending the stored reaction video data to the video output module 17 for decoding and output; the video output module 17 includes an H.265 video decoding module 171 and an HDMI interface module 172, which are connected to the clock module 11, the power module 12, the optical fiber Ethernet sending module 132, the MIPI interface module 141, and the SATA interface module 162; the video output module 17 allows receiving uncoded real-time monitoring video data transmitted by the MIPI interface module 141 and outputting it through the HDMI interface module 172, and can also receive reaction video data stored in the SATA hard disk module 161 transmitted by the SATA interface module 162, which is decoded by the H.265 video decoding module 171 and then transmitted to the HDMI interface module 172 or the optical fiber Ethernet data sending module 132; the data cache module 18 includes a DDR4 data cache module 181 and a DDR4 data control module 182, which are connected to the clock module 11, the power module 12, the SATA interface module 162, and the gigabit Ethernet communication module 19; the DDR4 data cache module 181 caches the encoded reaction video data transmitted by the gigabit Ethernet communication module 19 in real time at high speed, and the DDR4 data control module 182 transmits the real-time cached data to the SATA interface module 162 according to the timing requirements of the SATA interface; the gigabit Ethernet communication module 19 includes a gigabit Ethernet sending module 191 and a gigabit Ethernet receiving module 192, which are connected to the clock module 11, the power module 12, the optical fiber Ethernet data receiving module 131, the H.265 video encoding module 33, and the DDR4 data cache module 181; the gigabit Ethernet sending module 191 receives user instructions forwarded by the optical fiber Ethernet data receiving module 131 and sends them to the H.265 video encoding module 33, and the gigabit Ethernet receiving module 192 receives the encoded reaction video data transmitted by the H.265 video encoding module 33 and sends it to the DDR4 data cache module 181 for real-time high-speed caching.

[0054] Referring to Figure 1The user service module 2 comprises a user operation interface 21 and a user data storage module 22; the user operation interface 21 is connected with the optical fiber Ethernet data receiving module 131 and the user data storage module 22, to generate user operation instructions and send to the optical fiber Ethernet data receiving module 131, read reaction parameters and video data from the user data storage module 22 and display, to strengthen user interaction; the data storage module 22 is connected with the optical fiber Ethernet data sending module 132, to receive and store reaction parameters and video data.

[0055] Referring to Figure 1 The video encoding module 3 comprises an image sensor module 31, an MIPI interface module 32 and an H.265 video encoding module 33; the image sensor module 31 is connected with the MIPI interface module 32 and the flow chemistry equipment module 5, to collect reaction video data in real time and transmit to the MIPI interface module 32; the MIPI interface module 32 is connected with the image sensor module 31 and the H.265 video encoding module 33, to transmit the reaction video data collected by the image sensor module 31 to the H.265 video encoding module 33; the H.265 video encoding module 33 is connected with the gigabit Ethernet receiving module 192 and the MIPI interface module 32, to receive the uncoded reaction video data transmitted by the MIPI interface module 32 and perform H.265 encoding and then output to the gigabit Ethernet receiving module 192.

[0056] Referring to Figure 1The industrial control board 4 includes an RS485 module 41, a PWM output module 42, a relay matrix module 43, an ADC sampling module 44 and a motor driving module 45; the RS485 module 41 is connected with the real-time parameter acquisition module 152, the control signal generation module 154 and the flow chemistry equipment module 5, receives the control signal sent by the control signal generation module 154 and precisely controls the relevant flow chemistry equipment, and simultaneously transmits the feedback parameters of the relevant equipment to the real-time parameter acquisition module 152; the PWM output module 42 is connected with the control signal generation module 154 and the flow chemistry equipment module 5, receives the control signal and generates the corresponding PWM wave to realize the control of the relevant equipment in the flow chemistry equipment module 5; the relay matrix module 43 is connected with the control signal generation module 154 and the flow chemistry equipment module 5, receives the control signal and realizes the switching operation of the relay matrix to control the relevant equipment in the flow chemistry equipment module 5; the ADC sampling module 44 is connected with the real-time parameter acquisition module 152, the control signal generation module 154 and the flow chemistry equipment module 5, receives the control signal and realizes the real-time sampling of each experimental parameter in the flow chemistry equipment module 5, and transmits the sampling data to the real-time parameter acquisition module 152; the motor driving module 45 is connected with the control signal generation module 154 and the flow chemistry equipment module 5, receives the control signal and generates the motor control signal to drive the motor in the flow chemistry equipment module 5 to work precisely.

[0057] Referring to Figure 2After starting to work, the application will first generate detection instructions of each device by the power-on system state detection module, and send to the industrial control board, the industrial control board receives a series of detection instructions, sends corresponding instructions to each device, detects whether each device of the system is normal, if there is a device not in normal working state, the user will be notified to troubleshoot and power on again; under the premise that all devices are normal, the user enters the user operation interface, configures and operates each flow chemical experiment device, and can select whether to store reaction process video data, if the user selects to store reaction video data, the user operation interface will send a video encoding module start instruction and receive the encoded reaction video data output by the video encoding module in real time, the gigabit Ethernet interface receives the reaction video data and sends it into the DDR4 real-time cache, and stores the video data in the cache in the hard disk of the SATA interface; if the user selects not to store reaction video data, the operation of the user operation interface will be sent to the FPGA core control board through the fiber optical Ethernet communication module and transmitted to the control signal generation module, the control signal generation module receives the configuration instruction and generates the related control signal and sends it to the industrial control board, the industrial control board will control each experimental device of the flow chemistry according to each control signal. In the experiment process, the system samples, stores and analyzes each experimental parameter in real time, the FPGA core control board sends all experimental parameters and experimental progress to the user interaction module through the fiber optical Ethernet communication module until the experiment is completed.

[0058] The application can support n reaction lines to perform experiments simultaneously, and only one reaction line is used in the "traffic light reaction" experiment.

[0059] Referring to Figure 3 Taking the "traffic light reaction" experiment as an example, the flow chemistry device module 5 includes a photoelectric bubble sensor 51, a liquid storage bottle array 52, a vertical injection pump 53, an electromagnetic switching valve 54, a pressure sensor 55, a temperature control module 56, a flow chemistry reaction chip 57, a temperature sensor 58, a back pressure valve 59, a pH sensor 510, a product liquid storage bottle 511, a mass sensor 512 and a waste liquid storage bottle 513.

[0060] Referring to Figure 3 In the "traffic light reaction" experiment, the electrical connection part, the photoelectric bubble sensor 51 is connected with the ADC sampling module 44; the vertical injection pump 53 is connected with the RS485 module 41; the electromagnetic switching valve 54 is connected with the relay matrix module 43; the pressure sensor 55 is connected with the RS485 module 41; the temperature control module 56 is connected with the PWM output module 42; the temperature sensor 58 is connected with the ADC sampling module 44; the back pressure valve 59 is connected with the motor drive module 43; the pH sensor 510 is connected with the ADC sampling module 44; and the mass sensor 512 is connected with the ADC sampling module 44.

[0061] Referring to Figure 3 In the "Traffic Light Reaction" experiment, the non-electrically connected part, the image sensor module 141 monitors the entire intelligent reaction platform picture; the image sensor module 31 collects the picture of the flow chemical reaction chip 57 during the reaction process; the photoelectric bubble sensor 51 contacts the liquid storage bottle array 52 to detect whether the reaction liquid therein is sufficient; the reaction liquid in the liquid storage bottle array 52 is sucked into the vertical injection pump 53 through the channel of the electromagnetic switching valve 54; the liquid in the vertical injection pump 53 is injected into the pressure sensor 55 detection passage through the electromagnetic switching valve 54; after flowing through the pressure sensor 55, the reaction liquid enters the flow chemical reaction chip 57; the flow chemical reaction chip 57 is placed on the temperature control module 56; the temperature sensor 58 is placed on the flow chemical reaction chip 57 to detect the reaction temperature; the liquid fully reacted in the flow chemical reaction chip 57 flows through the pressure sensor 55; the back pressure valve 59 connected after the pressure sensor 55 controls the pressure of the entire reaction system; the electromagnetic switching valve 54 connected after the back pressure valve 59 distinguishes the product and waste liquid passage; the product enters the product liquid storage bottle 511 through the electromagnetic switching valve 54; the waste liquid enters the waste liquid storage bottle 513 through the electromagnetic switching valve 54; the product liquid storage bottle 511 is placed on the mass sensor 512; the pH sensor is placed inside the product liquid storage bottle 511.

[0062] Referring to Figure 3In the "traffic light reaction" experiment, the user's experimental operation is based on the user interface. After the system is powered on, the system state detection is automatically performed to ensure that each device is in a normal working state. If a device is not in a normal working state, the user interface will pop up a window to inform the user, and the user will power on again after troubleshooting. After starting the experiment, the user first switches the first electromagnetic switch valve to the first fluid channel, and operates the first vertical injection pump to suck 5 mL of sodium indigo disulfonate solution from the liquid bottle array at a flow rate of 5 mL / min; then switch the second electromagnetic switch valve to the first fluid channel, and operate the second vertical injection pump to suck 5 mL of alkaline glucose solution from the liquid bottle array at a flow rate of 5 mL / min; During the operation, the user can see the picture of the whole intelligent experiment platform and observe whether there are any sudden situations such as liquid leakage, and can also choose to save the video of the flow chemistry reaction chip. The image sensor will collect, encode and transmit the video of the flow chemistry reaction chip to the FPGA core control board, and store it in the SATA hard disk. Next, the user can set the reaction temperature of the flow chemistry reaction chip to 60°C, and the temperature sensor will collect the temperature data in real time and transmit it to the FPGA core control board. Once the temperature deviates from the set value, a control signal will be generated to drive the temperature control module to maintain a constant temperature. Then switch the first electromagnetic switch valve to the third fluid channel, and operate the first vertical injection pump to inject 5 mL of sodium indigo disulfonate solution at a flow rate of 1 mL / min; then switch the second electromagnetic switch valve to the third fluid channel, and operate the second vertical injection pump to inject 5 mL of alkaline glucose solution at a flow rate of 1 mL / min, and the two reactants are injected into the flow chemistry reaction chip for sufficient reaction; During the injection process, the user can observe the real-time measurement value of the three pressure sensors, and can adjust the pressure inside the reaction system to 80 kPa through the back pressure valve. During the experiment, the user can observe that the solution in the microfluidic chip will change color from green to red to yellow as the time and space change, and the pH sensor and mass sensor will detect the pH of the liquid in the product liquid bottle and the mass of the product in real time.

[0063] The above is only a further description of the present application and is not intended to limit the present application. Any equivalent implementation of the present application shall be included in the scope of the claims of the present application. For those skilled in the art, the technical solutions and inventive concepts of the present application can be replaced or changed, and all such changes or replacements shall be within the scope of protection of the claims of the present application.

Claims

1. An FPGA-based intelligent microfluidic chemical reaction platform, characterized in that, The platform includes an FPGA core control board (1), a user service module (2), a video encoding module (3), an industrial control board (4), and a flow chemistry equipment module (5). The FPGA core control board (1) is connected to the user service module (2), video encoding module (3), industrial control board (4) and flow chemistry equipment module (5) to receive and parse the instruction data sent by the user service module (2) and upload the experimental data collected in real time by the industrial control board (4) during the reaction process of the flow chemistry equipment module (5), and receive the encoded experimental monitoring video of the flow chemistry equipment module (5) output by the video encoding module (3); The user service module (2) is connected to the FPGA core control board (1) to receive experimental data and monitoring videos sent by the FPGA core control board (1) and send user operation instructions to the FPGA core control board (1). The video encoding module (3) is connected to the FPGA core control board (1) and the flow chemistry equipment module (5) to obtain the monitoring video of the flow chemistry equipment module (5) during the experiment and transmit the video to the FPGA core control board (1) for storage after H.265 encoding. The industrial control board (4) is connected to the FPGA core control board (1) and the flow chemistry equipment module (5) to receive control commands sent by the FPGA core control board (1), collect the values ​​of each experimental parameter in the reaction process of the flow chemistry equipment module (5) in real time, and transmit them to the FPGA core control board (1) for processing. The flow chemistry equipment module (5) is connected to the FPGA core control board (1) and the industrial control board (4) to receive and accurately execute control signals sent by the industrial control board (4). The reaction process image is acquired in real time by the FPGA core control board (1); wherein: The FPGA core control board (1) includes a clock module (11), a power module (12), a fiber optic Ethernet communication module (13), a MIPI image sensor module (14), a microfluidic chemical reaction control module (15), a video storage module (16), a video output module (17), a data cache module (18), and a gigabit Ethernet communication module (19). The clock module (11) is connected to the power module (12), the fiber optic Ethernet communication module (13), the video monitoring module (14), the microfluidic chemical reaction control module (15), the video storage module (16), the video output module (17), the data cache module (18), and the gigabit Ethernet communication module (19), providing a reference clock for each module; The power module (12) is connected to the clock module (11), the fiber optic Ethernet communication module (13), the MIPI image sensor module (14), the microfluidic chemical reaction control module (15), the video storage module (16), the video output module (17), the data cache module (18), and the gigabit Ethernet communication module (19), and supplies power to each module; The fiber optic Ethernet communication module (13) includes a fiber optic Ethernet data receiving module (131) and a fiber optic Ethernet data sending module (132), which are connected to the clock module (11), power supply module (12), microfluidic chemical reaction control module (15), video output module (17), gigabit Ethernet communication module (19) and user service module (2). The fiber optic Ethernet data receiving module (131) receives the operation instructions sent by the user service module (2) and transmits the operation instructions to the gigabit Ethernet communication module (19) and the microfluidic chemical reaction control module (15). The fiber optic Ethernet data sending module (132) receives the video signal output by the video output module (17), the various experimental data collected by the microfluidic chemical reaction control module (15) and the judgment results of the experimental progress, and sends the above data to the user service module (2) in TCP packet format. The video monitoring module (14) includes a MIPI interface module (141) and an image sensor module (142), which are connected to a clock module (11), a power supply module (12), a flow chemistry equipment module (5), and a video output module (17). The image sensor module (142) collects images of the flow chemistry equipment module (5) during the experiment in real time and transmits them to the video output module (17) through the MIPI interface module (141) for output display, for observation and demonstration of the experimental process. The microfluidic chemical reaction control module (15) includes a reaction progress judgment module (151), a real-time parameter acquisition module (152), a power-on system status detection module (153), and a control signal generation module (154). It is connected to a clock module (11), a power supply module (12), a fiber optic Ethernet data receiving module (131), a fiber optic Ethernet data sending module (132), and an industrial control board (4). The reaction progress judgment module (151) judges the reaction progress based on the experimental process parameters collected by the real-time parameter acquisition module (152) and transmits the results to the fiber optic Ethernet data sending module (132). The real-time parameter acquisition module (152) directly transmits the collected experimental process parameters to the fiber optic Ethernet data sending module (132). The power-on system status detection module (153) generates initialization check instructions for each component of the fluid chemical equipment module (5) when the system is powered on, and generates corresponding control signals through the control signal generation module (154) to check the status of the initially powered-on system and ensure that each component functions normally. The video storage module (16) includes a SATA hard disk module (161) and a SATA interface module (162), which are connected to the clock module (11), the power module (12), the video output module (17) and the data cache module (18). The SATA interface module (162) receives the encoded reaction video data from the data cache module (18) and stores it in the SATA hard disk module (161). At the same time, it sends the stored reaction video data to the video output module (17) for decoding and output. The video output module (17) includes an H.265 video decoding module (171) and an HDMI interface module (172), and is connected to a clock module (11), a power module (12), a fiber optic Ethernet transmission module (132), a MIPI interface module (141), and a SATA interface module (162). It allows receiving unencoded real-time monitoring video data transmitted by the MIPI interface module (141) and outputting it through the HDMI interface module (172). It can also receive response video data stored in the SATA hard disk module (161) transmitted by the SATA interface module (162), and transmit it to the HDMI interface module (172) or the fiber optic Ethernet data transmission module (132) after decoding by the H.265 video decoding module (171). The data caching module (18) includes a DDR4 data caching module (181) and a DDR4 data control module (182), which are connected to the clock module (11), the power module (12), the SATA interface module (162) and the gigabit Ethernet communication module (19). The DDR4 data caching module (181) caches the encoded reaction video data transmitted from the gigabit Ethernet communication module (19) in real time at high speed. The DDR4 data control module (182) transmits the real-time cached data to the SATA interface module (162) according to the timing requirements of the SATA interface. The gigabit Ethernet communication module (19) includes a gigabit Ethernet transmitting module (191) and a gigabit Ethernet receiving module (192), which are connected to a clock module (11), a power module (12), a fiber optic Ethernet data receiving module (131), an H.265 video encoding module (33), and a DDR4 data cache module (181). The gigabit Ethernet transmitting module (191) receives user instructions forwarded by the fiber optic Ethernet data receiving module (131) and sends them to the H.265 video encoding module (33). The gigabit Ethernet receiving module (192) receives the encoded response video data transmitted by the H.265 video encoding module (33) and sends it to the DDR4 data cache module (181) for high-speed caching in real time.

2. The FPGA-based intelligent microfluidic chemical reaction platform according to claim 1, characterized in that, The user service module (2) includes a user operation interface (21) and a user data storage module (22). The user interface (21) is connected to the fiber optic Ethernet data receiving module (131) and the user data storage module (22) to generate user operation instructions and send them to the fiber optic Ethernet data receiving module (131), read reaction parameters and video data from the user data storage module (22) and display them, thereby enhancing user interaction; The data storage module (22) is connected to the fiber optic Ethernet data transmission module (132) to receive and store reaction parameters and video data.

3. The FPGA-based intelligent microfluidic chemical reaction platform according to claim 1, characterized in that, The video encoding module (3) includes an image sensor module (31), a MIPI interface module (32), and an H.265 video encoding module (33). The image sensor module (31) is connected to the MIPI interface module (32) and the flow chemistry device module (5) to collect reaction video data in real time and transmit it to the MIPI interface module (32). The MIPI interface module (32) is connected to the image sensor module (31) and the H.265 video encoding module (33) to transmit the reaction video data collected by the image sensor module (31) to the H.265 video encoding module (33). The H.265 video encoding module (33) is connected to the Gigabit Ethernet receiving module (192) and the MIPI interface module (32). It receives the unencoded reaction video data transmitted from the MIPI interface module (32), performs H.265 encoding, and outputs it to the Gigabit Ethernet receiving module (192).

4. The FPGA-based intelligent microfluidic chemical reaction platform according to claim 1, characterized in that, The industrial control board (4) includes an RS485 module (41), a PWM output module (42), a relay matrix module (43), an ADC sampling module (44), and a motor drive module (45). The RS485 module (41) is connected to the real-time parameter acquisition module (152), the control signal generation module (154) and the flow chemistry equipment module (5). It receives the control signal sent by the control signal generation module (154) and accurately controls the relevant flow chemistry equipment. At the same time, it transmits the feedback parameters of the relevant equipment to the real-time parameter acquisition module (152). The PWM output module (42) is connected to the control signal generation module (154) and the flow chemistry equipment module (5), and receives the control signal and generates the corresponding PWM wave to control the relevant equipment in the flow chemistry equipment module (5); The relay matrix module (43) is connected to the control signal generation module (154) and the flow chemistry equipment module (5), receives control signals and performs switching operations on the relay matrix to control the relevant equipment in the flow chemistry equipment module (5); The ADC sampling module (44) is connected to the real-time parameter acquisition module (152), the control signal generation module (154) and the flow chemistry device module (5). It receives control signals and samples each experimental parameter in the flow chemistry device module (5) in real time, and transmits the sampled data to the real-time parameter acquisition module (152). The motor drive module (45) is connected to the control signal generation module (154) and the flow chemistry equipment module (5), receives control signals and generates motor control signals to drive the motor in the flow chemistry equipment module (5) to work precisely.

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