Zeolite tooth cleaning toothpaste and preparation method thereof

Abstract

The invention relates to multifunctional zeolite tooth-cleaning toothpaste and a preparation method thereof. The multifunctional zeolite tooth-cleaning toothpaste is prepared from the following raw materials: zeolite, pumice stone, polyethylene glycol, disodium dihydrogen pyrophosphate, carbon powder, zinc citrate and auxiliaries. According to the toothpaste, the raw materials are compounded for use, so that the toothpaste has a synergistic effect, has the effects of promoting whitening, freshening breath, removing dental plaque, removing tooth stains and the like, and also has an effect of freshening breath.

Description

Technical Field

[0001] The present invention relates to the technical field of toothpaste preparation, and particularly relates to a zeolite teeth-cleaning toothpaste and a preparation method thereof. Background Art

[0002] In today's society, people are increasingly concerned about oral hygiene and health, and having healthy and bright teeth has gradually become the pursuit goal of people. And various problems such as yellow and black teeth, dental stains, bad breath, and dental plaque affect dental health. Among them, the main sources of yellow and black teeth and dental stains are divided into exogenous stains and endogenous stains. Exogenous stains are due to the presence of various bacteria on the tooth surface, which secrete many viscous substances, and the tea stains, tobacco stains in daily diet and certain minerals in drinking water are adsorbed on these viscous substances, gradually making the teeth turn yellow or black. Endogenous staining is formed during tooth development. For example, when tetracycline is deposited in dentin, the teeth will turn yellow, brown or dark gray, which is called tetracycline teeth.

[0003] Bad breath is divided into oral halitosis and non-oral halitosis. Oral halitosis is the bad breath caused by oral problems. For example, the massive accumulation of dental plaque, dental soft deposits, dental calculus, as well as gingivitis, periodontitis, oral mucosal diseases, and dental caries are the most common causes of oral halitosis. Among them, the halitosis caused by extensive dental caries and periodontitis is more common. Not paying attention to oral hygiene is also the most common cause of bad breath, which is related to not brushing teeth, not rinsing mouth, or not brushing teeth thoroughly. The long-term accumulation of food residues in the mouth ferments and decomposes under the action of bacteria, producing substances such as indole mercapto group and amines, emitting a rotten stench.

[0004] Therefore, how to achieve a multi-functional toothpaste has become an urgent problem to be solved at present. Summary of the Invention

[0005] To solve the above technical problems, the present invention provides a multi-functional zeolite teeth-cleaning toothpaste and a preparation method. In the present invention, zeolite, pumice, polyethylene glycol, sodium acid pyrophosphate, carbon powder and zinc citrate are compounded and used, which has a synergistic effect, and at the same time can promote whitening, freshen breath, remove dental plaque, remove dental stains and other effects, and also has the effect of freshening breath.

[0006] To achieve this purpose, the present invention adopts the following technical solutions:

[0007] In the first aspect, the present invention provides a multi-functional zeolite teeth-cleaning toothpaste, and the raw materials of the multi-functional zeolite teeth-cleaning toothpaste include zeolite, pumice, polyethylene glycol, sodium acid pyrophosphate, carbon powder, zinc citrate and additives.

[0008] In the present invention, six components, namely zeolite, pumice, polyethylene glycol, sodium acid pyrophosphate, carbon powder and zinc citrate, are used in combination. Among them, zeolite and pumice have the effect of polishing and whitening teeth, polyethylene glycol-8 and sodium acid pyrophosphate have the effect of removing dental stains and tobacco stains, carbon powder has the effect of refreshing breath, and zinc citrate can inhibit oral bacteria and the formation of dental plaque. In the present invention, the above raw materials are compounded and used, which can not only exert the effects produced by each raw material itself, but also promote the effects of whitening, refreshing breath, removing dental plaque and removing dental stains, and also has the effect of refreshing breath.

[0009] Preferably, the polyethylene glycol includes polyethylene glycol-8.

[0010] Preferably, the raw materials of the multi-functional zeolite toothpaste for cleaning teeth include 0.1-1 part of zeolite, 0.005-0.02 part of pumice, 1-5 parts of polyethylene glycol-8, 0.5-3 parts of sodium acid pyrophosphate, 0.01-0.1 part of carbon powder, 0.1-0.8 part of zinc citrate and 0.01-108.63 parts of auxiliary agent. The 0.1-1 part can be, for example, 0.1 part, 0.2 part, 0.4 part, 0.6 part, 0.8 part or 1 part, etc. The 0.005-0.02 part can be, for example, 0.005 part, 0.01 part, 0.012 part, 0.014 part, 0.016 part, 0.018 part or 0.02 part, etc. The 1-5 parts can be, for example, 1 part, 2 part, 3 part, 4 part or 5 part. The 0.5-3 parts can be, for example, 0.5 part, 1 part, 1.5 part, 2 part, 2.5 part or 3 part, etc. The 0.01-0.1 part can be, for example, 0.01 part, 0.02 part, 0.04 part, 0.06 part, 0.08 part or 0.1 part, etc. The 0.1-0.8 part can be, for example, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part or 0.8 part, etc. The 0.01-108.63 parts can be, for example, 0.01 part, 0.1 part, 1 part, 10 parts, 50 parts, 100 parts or 108.63 parts, etc.

[0011] Preferably, the auxiliary agent includes any one or a combination of at least two of a humectant, a solvent, an abrasive, a foaming agent, an aromatic agent, a thickening agent, a preservative, a pH regulator or a taste improver.

[0012] The auxiliary agent includes, by weight parts, 0.5 - 40 parts of a humectant, 30 - 38 parts of a solvent, 15 - 20 parts of an abrasive, 0.01 - 5.83 parts of a foaming agent, 0.05 - 1.2 parts of an aromatic agent, 0.1 - 1.8 parts of a thickening agent, 0.1 - 1 part of a preservative, 0.1 - 0.3 parts of a pH regulator or 0.05 - 0.5 parts of a taste improver. The 0.5 - 40 parts can be, for example, 0.5 part, 1 part, 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts or 40 parts, etc. The 30 - 38 parts can be, for example, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts and 38 parts. The 15 - 20 parts can be, for example, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts or 20 parts, etc. The 0.01 - 5.83 parts can be, for example, 0.01 part, 0.1 part, 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts or 5.83 parts, etc. The 0.05 - 1.2 parts can be, for example, 0.05 part, 0.1 part, 0.2 part, 0.4 part, 0.6 part, 0.8 part, 1 part or 1.2 parts, etc. The 0.1 - 1.8 parts can be, for example, 0.1 part, 0.2 part, 0.4 part, 0.6 part, 0.8 part, 1 part, 1.2 part, 1.4 part, 1.6 part or 1.8 parts, etc. The 0.1 - 1 part can be, for example, 0.1 part, 0.2 part, 0.4 part, 0.6 part, 0.8 part or 1 part, etc. The 0.1 - 0.3 parts can be, for example, 0.1 part, 0.15 part, 0.2 part, 0.25 part or 0.3 part, etc. The 0.05 - 0.5 parts can be, for example, 0.05 part, 0.1 part, 0.2 part, 0.3 part, 0.4 part or 0.5 part, etc.

[0013] Preferably, the humectant includes, by weight parts, 33 - 38 parts of sorbitol and / or 0.5 - 2 parts of xylitol. The 33 - 38 parts can be, for example, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts or 38 parts, etc. The 0.5 - 2 parts can be, for example, 0.5 part, 1 part, 1.5 parts or 2 parts.

[0014] Preferably, the solvent includes, by weight parts, 30 - 38 parts of water, for example, 30 parts, 31 parts, 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts and 38 parts.

[0015] Preferably, the abrasive includes, by weight parts, 15 - 20 parts of hydrated silica, for example, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts or 20 parts, etc.

[0016] Preferably, the water absorption of the silica hydrate includes (2.4 - 2.6) mL / g and / or (0.85 - 1) mL / g. The (2.4 - 2.6) mL / g can be, for example, 2.4 mL / g, 2.45 mL / g, 2.5 mL / g, 2.55 mL / g, or 2.6 mL / g, etc. The (0.85 - 1) mL / g can be, for example, 0.85 mL / g, 0.90 mL / g, 0.95 mL / g, or 1 mL / g, etc.

[0017] Preferably, the foaming agent includes, by weight, any one or a combination of at least two of 1 - 4 parts of sodium lauryl sulfate, 0.5 - 1.5 parts of cocoamidopropyl betaine, 0.01 - 0.03 parts of sodium benzoate, or 0.1 - 0.3 parts of sodium chloride. The 1 - 4 parts can be, for example, 1 part, 2 parts, 3 parts, or 4 parts, etc. The 0.5 - 1.5 parts can be, for example, 0.5 parts, 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.4 parts, or 1.5 parts, etc. The 0.1 - 0.3 parts can be, for example, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, or 0.3 parts, etc. The 0.01 - 0.03 parts can be, for example, 0.01 parts, 0.015 parts, 0.02 parts, 0.025 parts, or 0.03 parts, etc.

[0018] Preferably, the fragrance includes, by weight, 0.5 - 1 part of freesia essence and / or 0.05 - 0.2 part of cooling essence. The 0.5 - 1 part can be, for example, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, or 1 part, etc. The 0.05 - 0.2 part can be, for example, 0.05 parts, 0.06 parts, 0.08 parts, 0.1 parts, 0.12 parts, 0.14 parts, 0.16 parts, 0.18 parts, or 0.2 parts, etc.

[0019] Preferably, the thickener includes, by weight, 0.1 - 1 part of cellulose gum and / or 0.2 - 0.8 part of xanthan gum. The 0.1 - 1 part can be, for example, 0.1 parts, 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, or 1 part, etc. The 0.2 - 0.8 part can be, for example, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, or 0.8 parts, etc.

[0020] Preferably, the preservative includes, by weight, 0.1 - 0.5 part of sodium benzoate and / or 0.1 - 0.5 part of sodium fluoride. The 0.1 - 0.5 part can be, for example, 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, or 0.5 parts, etc.

[0021] Preferably, the pH regulator includes, by weight, 0.1 - 0.3 part of sodium hydroxide, for example, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, or 0.3 parts, etc.

[0022] Preferably, the taste improver comprises 0.1-0.3 parts by weight of trichlorogalactose and / or 0.05-0.2 parts by weight of menthone glycerol ketal. The 0.1-0.3 parts can be, for example, 0.1 part, 0.15 parts, 0.2 parts, 0.25 parts or 0.3 parts, etc. The 0.05-0.2 parts can be, for example, 0.05 part, 0.06 part, 0.08 part, 0.1 part, 0.12 part, 0.14 part, 0.16 part, 0.18 part or 0.2 parts, etc.

[0023] In a second aspect, the present invention provides a preparation method of the multi-functional zeolite toothpaste according to the first aspect, the preparation method comprising preparing by stirring zeolite, pumice, polyethylene glycol, disodium dihydrogen pyrophosphate, carbon powder, zinc citrate and an auxiliary agent.

[0024] In the present invention, the raw materials are stirred and mixed evenly, the preparation method is simple, no large-scale instruments are required, the operation is simple, the requirements for the ability of technicians are not high, and it is more conducive to industrial production.

[0025] Preferably, the preparation method further comprises a pretreatment.

[0026] Preferably, the pretreatment comprises obtaining raw material 1 by stirring a friction agent, a thickening agent and pumice for 1 time, and obtaining raw material by stirring a solvent, disodium dihydrogen pyrophosphate, xylitol, zinc citrate, a preservative, a pH regulator and trichlorogalactose for 2 times.

[0027] Preferably, the speed of the stirring 1 is 10-50 rpm, and can be, for example, 10 rpm, 20 rpm, 30 rpm, 40 rpm or 50 rpm, etc.

[0028] Preferably, the speed of the stirring 2 is 0-1000 rpm, and can be, for example, 0 rpm, 100 rpm, 200 rpm, 300 rpm, 400 rpm, 500 rpm, 600 rpm, 700 rpm, 800 rpm, 900 rpm or 1000 rpm, etc.

[0029] Preferably, the preparation method comprises stirring sorbitol, polyethylene glycol-8, carbon powder and raw material 2 evenly, then adding sodium lauryl sulfate, zeolite and raw material 1 and stirring evenly, and then adding the remaining foaming agent, fragrance and menthone glycerol ketal and stirring evenly, and performing vacuum defoaming to obtain the product.

[0030] Compared with the prior art, the present invention has at least the following beneficial effects:

[0031] The multi-functional zeolite teeth-cleaning toothpaste provided by the present invention uses six components in combination: zeolite, pumice, polyethylene glycol-8, sodium acid pyrophosphate, carbon powder, and zinc citrate. Among them, zeolite and pumice have the effect of polishing and whitening, polyethylene glycol-8 and sodium acid pyrophosphate have the effect of removing dental stains and tobacco stains, carbon powder has the effect of refreshing the breath, and zinc citrate can inhibit oral bacteria and the formation of dental plaque. This toothpaste has the effects of promoting whitening, refreshing the breath, removing dental plaque and dental stains, etc., and also has the function of refreshing the breath. Detailed implementation mode

[0032] To facilitate the understanding of the present invention, the following examples are listed. Those skilled in the art should understand that the said examples are only for helping to understand the present invention and should not be regarded as specific limitations on the present invention.

[0033] The sources of the reagents used in the following examples are as follows:

[0034] Zeolite: Luoyang Jianlong Weina New Materials Co., Ltd., zeolite JLTPZ-1;

[0035] Pumice: Guangzhou Landai Biotechnology Co., Ltd., pumice;

[0036] Polyethylene glycol-8: Clariant Chemical Technology (Shanghai) Co., Ltd., Dow Chemical (Shanghai) Co., Ltd., PEG-400;

[0037] Sodium acid pyrophosphate: Jiangsu Debang Duoling Health Technology Co., Ltd., sodium acid pyrophosphate;

[0038] Carbon powder: Nanjing Spic Science & Technology Co., Ltd., bamboo carbon powder (200 mesh);

[0039] Zinc citrate: SUCROAL S.A., zinc citrate;

[0040] Freesia fragrance: AAM78037 / 00, Canban;

[0041] Cooling fragrance: AAK20633_00, COOL SHOT Cooling Critical Hit fragrance, Canban.

[0042] Examples 1-3

[0043] This example provides a multi-functional zeolite teeth-cleaning toothpaste

[0044] The formula of the multi-functional zeolite teeth-cleaning toothpaste prepared in Examples 1-3 is shown in Table 1.

[0045] Table 1

[0046]

[0047]

[0048] Preparation method of multi-functional zeolite teeth-cleaning toothpaste:

[0049] The friction agent, thickener and pumice are stirred at a speed of 30 rpm to obtain Raw material 1, and the solvent, sodium acid pyrophosphate, xylitol, zinc citrate, preservative, pH regulator and trichlorogalactosyl are stirred at a speed of 500 rpm to obtain Raw material 2.

[0050] Sorbitol, polyethylene glycol-8, carbon powder and Raw material 2 are stirred evenly at a speed of 700 rpm, then sodium lauryl sulfate, zeolite and Raw material 1 are added and stirred evenly at a speed of 1200 rpm, and then the remaining foaming agent, fragrance and menthone glycerol ketal are added and stirred evenly at a speed of 900 rpm, and then vacuum defoaming is carried out to prepare the product.

[0051] Example 4

[0052] This example provides a multi-functional zeolite teeth-cleaning toothpaste, the difference from Example 1 is only that the hydrated silica with a water absorption of 2.5 mL / g is not included in the preparation raw materials, and the reduced mass is distributed to the hydrated silica with a water absorption of 0.9 mL / g according to the ratio of Example 1, and the rest is the same as Example 1.

[0053] Example 5

[0054] This example provides a multi-functional zeolite teeth-cleaning toothpaste, the difference from Example 1 is only that the hydrated silica with a water absorption of 0.9 mL / g is not included in the preparation raw materials, and the reduced mass is distributed to the hydrated silica with a water absorption of 2.5 mL / g according to the ratio of Example 1, and the rest is the same as Example 1.

[0055] Comparative Example 1

[0056] This comparative example provides a multi-functional zeolite teeth-cleaning toothpaste, the difference from Example 1 is only that zeolite is not included in the preparation raw materials, and the reduced mass is distributed to pumice, polyethylene glycol-8, sodium acid pyrophosphate, carbon powder and zinc citrate according to the ratio of Example 1, and the rest is the same as Example 1.

[0057] Comparative Example 2

[0058] This comparative example provides a multi-functional zeolite teeth-cleaning toothpaste, the difference from Example 1 is only that pumice is not included in the preparation raw materials, and the reduced mass is distributed to zeolite, polyethylene glycol-8, sodium acid pyrophosphate, carbon powder and zinc citrate according to the ratio of Example 1, and the rest is the same as Example 1.

[0059] Comparative Example 3

[0060] This comparative example provides a multi-functional zeolite toothpaste for cleaning teeth. The difference from Example 1 is only that polyethylene glycol-8 is not included in the preparation raw materials, and the reduced mass is distributed to zeolite, pumice, sodium acid pyrophosphate, carbon powder and zinc citrate according to the ratio of Example 1, and the rest is the same as Example 1.

[0061] Comparative Example 4

[0062] This comparative example provides a multi-functional zeolite toothpaste for cleaning teeth. The difference from Example 1 is only that sodium acid pyrophosphate is not included in the preparation raw materials, and the reduced mass is distributed to zeolite, pumice, polyethylene glycol-8, carbon powder and zinc citrate according to the ratio of Example 1, and the rest is the same as Example 1.

[0063] Comparative Example 5

[0064] This comparative example provides a multi-functional zeolite toothpaste for cleaning teeth. The difference from Example 1 is only that carbon powder is not included in the preparation raw materials, and the reduced mass is distributed to zeolite, pumice, polyethylene glycol-8, sodium acid pyrophosphate and zinc citrate according to the ratio of Example 1, and the rest is the same as Example 1.

[0065] Comparative Example 6

[0066] This comparative example provides a multi-functional zeolite toothpaste for cleaning teeth. The difference from Example 1 is only that zinc citrate is not included in the preparation raw materials, and the reduced mass is distributed to zeolite, pumice, polyethylene glycol-8, sodium acid pyrophosphate and carbon powder according to the ratio of Example 1, and the rest is the same as Example 1.

[0067] Comparative Example 7

[0068] This comparative example provides a multi-functional zeolite toothpaste for cleaning teeth. The difference from Example 1 is only that a commercially available ordinary toothpaste is used in this comparative example, and the rest is the same as Example 1.

[0069] Test Example 1

[0070] This test example conducts a whitening effect detection.

[0071] Select caries-free bovine teeth. After cleaning and sterilization, process them into enamel specimen blocks through steps such as cutting, embedding, and polishing. Soak the blocks alternately in 1% hydrochloric acid, saturated sodium carbonate, and 1% phytic acid for 1 minute each, then rinse them thoroughly and place them in black tea, coffee, soy sauce, and ferric chloride solution respectively for 48 hours of staining. After staining, take out the blocks, rinse them, dry them, and measure the whiteness value of the enamel surface of each block with a color difference meter. Randomly distribute the blocks, with 8 in each group, and perform a difference test using analysis software, ensuring that there are no significant differences among the groups. Prepare the toothpaste of the above-mentioned examples and comparative examples according to a ratio of 1:3, and conduct simulated brushing for 7 days respectively. The only difference in the operation of each group is the sample, and the toothpaste usage, brushing time, etc. are all kept consistent. After the simulated brushing is over, rinse the blocks, dry them, and measure the whiteness value and color scale of the enamel surface of the blocks with a color difference meter, analyze the trend of the readings, calculate the difference in whiteness value before and after simulated brushing, analyze the significant differences, and calculate the average color scale. The specific results are shown in Table 1.

[0072] Table 1

[0073] Group Difference in whiteness value Average color level Example 1 12.53 9 Example 2 11.94 9 Example 3 11.92 8 Example 4 11.75 8 Example 5 11.47 7 Comparative Example 1 4.54 13 Comparative Example 2 3.50 12 Comparative Example 3 3.31 12 Comparative Example 4 3.27 12 Comparative Example 5 3.25 11 Comparative Example 6 2.66 11 Comparative Example 7 2.56 10

[0074] As can be seen from Table 1, zeolite, pumice, polyethylene glycol-8, disodium dihydrogen pyrophosphate, carbon powder, and zinc citrate can significantly improve the tooth whitening effect.

[0075] Test Example 2

[0076] In this test example, a test for removing dental plaque is carried out.

[0077] Streptococcus mutans is the main bacterium causing dental diseases in dental plaque. Taking Streptococcus mutans as the research object, use a toothbrush with toothpaste to brush a bovine tooth module with Streptococcus mutans 50 times, and recover the number of residual colonies on the bovine tooth module. Calculate the removal rate of this toothpaste on dental plaque by comparing with the number of colonies recovered from the bovine tooth module not brushed with a toothbrush.

[0078] (1) Preparation of bacterial suspension

[0079] Inoculate Streptococcus mutans on a TSA agar plate and culture it anaerobically at 36°C for 48 hours. Use an inoculation loop to pick a typical colony of the first-generation culture and streak it on a TSA agar plate, and culture it anaerobically at 36°C for 48 hours to obtain the second-generation culture. Pick and isolate fresh colonies of the third generation, mix them with PBS, and adjust the bacterial concentration to 10 8 cfu / mL to prepare a bacterial suspension for standby.

[0080] (2) Cultivation of in vitro dental plaque

[0081] Place the sterilized bovine tooth module in a sterile bottle, add 10 mL of bacterial suspension and 10 mL of BHI broth to each bottle, and culture it anaerobically at 36°C for 24 hours.

[0082] (3) Toothpaste simulation brushing treatment and counting

[0083] Take an unused toothbrush, squeeze about 1 cm of toothpaste onto the toothbrush, fix the bovine tooth, brush the bovine tooth with the toothbrush, move back and forth 50 times, rinse the toothpaste foam on the surface of the bovine tooth with sterile water, and immediately place the bovine tooth in a sterile homogenization bag, elute it with 20 mL of SCDLP, incubate anaerobically at 36 °C for 48 h, then count, and record the average value as A CFU.

[0084] For 3 bovine teeth that have not been brushed, place the bovine teeth in a sterile homogenization bag, put each one into a bag containing 20 mL of SCDLP for elution, incubate anaerobically at 36 °C for 48 h, then count, and record the average value as B CFU.

[0085] (4) Result calculation

[0086] Colony counts will be counted within the range of 30 - 300. For each repetition, the colony count is calculated by multiplying the value read on the plate by the dilution factor. Two significant figures are used during the calculation process. After calculation, convert the CFU result of each repetition to a log 10 value, and calculate the average value of 3 teeth. The plaque bacteria removal rate is calculated according to the following formula: Removal rate (%) = (B - A) / B × 100%. The specific results are shown in Table 2.

[0087] Table 2

[0088] Group Clearance rate (%) Example 1 99.99 Example 2 99.85 Example 3 99.14 Example 4 98.87 Example 5 98.42 Comparative Example 1 54.68 Comparative Example 2 54.13 Comparative Example 3 53.98 Comparative Example 4 53.57 Comparative Example 5 53.12 Comparative Example 6 53.09 Comparative Example 7 52.99

[0089] From the results in Table 2, it can be seen that the present invention can effectively remove dental plaque, indicating that it can effectively prevent the formation of dental plaque.

[0090] Test Example 3

[0091] This test example conducts a fresh breath detection

[0092] The main components contained in bad breath gas are volatile sulfides, including methanethiol, hydrogen sulfide, and dimethyl sulfide, which are produced by various reasons, and about 90% of them originate from the oral cavity. In this experiment, by simulating the use process of oral care products in vitro, cultivating the production of volatile sulfides from the oral saliva secretions of volunteers, and measuring methanethiol, etc. to evaluate the fresh breath effect.

[0093] Saliva of volunteers was obtained, and hydroxyapatite tablets were cultured overnight to form acquired biofilms. The hydroxyapatite tablets were respectively immersed in the toothpastes prepared in the above-mentioned examples and comparative examples for 2 min, taken out and placed in headspace bottles, 3 mL of saliva culture medium solution was added, and cultured for 16 h for gas phase analysis to obtain the peak area of methanethiol, and lg(peak area of methanethiol) was further calculated. Among them, the hydroxyapatite tablets in the blank control group were immersed in deionized water, and the rest were the same as the above steps, and the significant differences between each group and the blank control group were calculated. The specific results are shown in Table 3

[0094] Table 3

[0095] Group lg(peak area of methanethiol) Significance Example 1 4.603 0.559 Example 2 4.675 0.536 Example 3 4.825 0.497 Example 4 4.888 0.486 Example 5 4.925 0.481 Comparative Example 1 5.036 0.186 Comparative Example 2 5.095 0.181 Comparative Example 3 5.113 0.175 Comparative Example 4 5.144 0.164 Comparative Example 5 5.372 0.157 Comparative Example 6 5.389 0.142 Comparative Example 7 5.476 0.137 Blank control group 12.782 /

[0096] Through result analysis, it can be seen that the sample prepared by the present invention can significantly reduce the production of methanethiol after co-culturing with saliva for 16 h, and has the effect of refreshing the breath

[0097] Test Example 4

[0098] This test example conducts a detection of persistent cool feeling

[0099] In this test, through the form of a consumer questionnaire, 64 healthy subjects were collected to evaluate the relevant evaluations of the test products 120 min after single use under normal conditions, and the time for the products to maintain a cool feeling was evaluated

[0100] The usage method is to use the toothpastes prepared in the above-mentioned examples and comparative examples, brush teeth for 3 min, and the amount of toothpaste used is 1 cm. The age of the subjects is 19 - 56 years old, and the ratio of the number of males to females is 3:5. The specific results are shown in Table 4

[0101] Table 4

[0102]

[0103] In the present invention, through a specific toothpaste formula, the time of oral cool feeling is significantly increased, and oral problems can be cared for periodontitis, oral problems are improved, bad breath is relieved, and oral odor is removed. The above experiments can prove that the zeolite teeth-cleaning toothpaste prepared by the present invention has multiple effects, and significantly improves the sensory experience, efficacy experience and use safety of toothpaste use

[0104] In summary, in the present invention, the compound use of zeolite, pumice, polyethylene glycol-8, sodium acid pyrophosphate, carbon powder and zinc citrate has a synergistic effect, and can promote whitening, refresh the breath, remove dental plaque, remove dental stains and other effects, and also has the effect of refreshing the breath

[0105] The applicant declares that the above is only the specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Those skilled in the art should understand that any changes or substitutions that can be easily conceived by any person skilled in the art within the technical scope disclosed by the present invention fall within the protection scope and the disclosure scope of the present invention.

Claims

1. A multi-functional zeolite tooth-cleansing toothpaste, characterized in that: The raw materials of the multi-functional zeolite tooth-cleaning toothpaste include zeolite, pumice, polyethylene glycol, disodium dihydrogen pyrophosphate, carbon powder, zinc citrate and auxiliary agents.

2. The multifunctional zeolite tooth-cleansing toothpaste according to claim 1, characterized in that: The polyethylene glycol includes polyethylene glycol-8; Preferably, the raw materials of the multifunctional zeolite tooth-cleansing toothpaste include 0.1-1 parts of zeolite, 0.005-0.02 parts of pumice, 1-5 parts of polyethylene glycol-8, 0.5-3 parts of disodium dihydrogen pyrophosphate, 0.01-0.1 parts of carbon powder, 0.1-0.8 parts of zinc citrate and 0.01-108.63 parts of additives.

3. The multifunctional zeolite tooth-cleansing toothpaste according to claim 1 or 2, characterized in that: The auxiliary agent includes any one of a moisturizer, a solvent, a friction agent, a foaming agent, a fragrance, a thickener, a preservative, a pH regulator or a taste improver, or a combination of at least two of them.

4. The multifunctional zeolite tooth-cleansing toothpaste according to claim 3, characterized in that: The auxiliary agent comprises, by weight, any one of 0.5-40 parts of moisturizer, 30-38 parts of solvent, 15-20 parts of abrasive, 0.01-5.83 parts of foaming agent, 0.05-1.2 parts of fragrance, 0.1-1.8 parts of thickener, 0.1-1 parts of preservative, 0.1-0.3 parts of pH regulator or 0.05-0.5 parts of taste improver or a combination of at least two thereof; Preferably, the moisturizing agent comprises 33-38 parts of sorbitol and / or 0.5-2 parts of xylitol by weight; Preferably, the solvent comprises 30-38 parts of water by weight; Preferably, the friction agent comprises 15-20 parts by weight of hydrated silica; Preferably, the water absorption of the hydrated silica includes (2.4-2.6) mL / g and / or (0.85-1) mL / g.

5. The multifunctional zeolite tooth-cleansing toothpaste according to claim 3 or 4, characterized in that: The foaming agent comprises, by weight, any one of 1-4 parts of sodium lauryl sulfate, 0.5-1.5 parts of cocamidopropyl betaine, 0.01-0.03 parts of sodium benzoate or 0.1-0.3 parts of sodium chloride, or a combination of at least two thereof; Preferably, the fragrance comprises 0.5-1 parts of freesia essence and / or 0.05-0.2 parts of cooling essence by weight.

6. The multifunctional zeolite tooth-cleansing toothpaste according to any one of claims 3 to 5, characterized in that: The thickener comprises 0.1-1 parts of cellulose gum and / or 0.2-0.8 parts of xanthan gum by weight; Preferably, the preservative comprises 0.1-0.5 parts by weight of sodium benzoate and / or 0.1-0.5 parts by weight of sodium fluoride.

7. A method for preparing the multifunctional zeolite tooth-cleansing toothpaste according to claims 3-6, characterized in that: The pH regulator includes 0.1-0.3 parts of sodium hydroxide by weight; Preferably, the taste improver comprises 0.1-0.3 parts of trichlorogalactose and / or 0.05-0.2 parts of menthone glycerol ketal by weight.

8. A method for preparing the multifunctional zeolite tooth-cleansing toothpaste according to claims 3-7, characterized in that: The preparation method comprises the steps of stirring zeolite, pumice, polyethylene glycol, disodium dihydrogen pyrophosphate, carbon powder, zinc citrate and an auxiliary agent to obtain the product.

9. The method for preparing the multifunctional zeolite tooth-cleansing toothpaste according to claim 8, characterized in that: The preparation method further comprises pretreatment; Preferably, the pretreatment comprises stirring 1 the abrasive, the thickener and the pumice stone to obtain the raw material 1, and stirring 2 the solvent, the disodium dihydrogen pyrophosphate, the xylitol, the zinc citrate, the preservative, the pH regulator and the trichlorogalactose to obtain the raw material 2; Preferably, the stirring speed 1 is 10-50 rpm; Preferably, the stirring speed 2 is 0-1000 rpm.

10. The method for preparing the multifunctional zeolite tooth-cleansing toothpaste according to claim 9, characterized in that: The preparation method comprises the steps of evenly stirring sorbitol, polyethylene glycol-8, carbon powder and raw material 2, then adding sodium lauryl sulfate, zeolite and raw material 1 and stirring evenly, then adding the remaining foaming agent, fragrance and menthone glycerol acetal and stirring evenly, and performing vacuum defoaming to obtain the product.

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