Formula for treating cold in uterus, dysmenorrhea and cold hands and feet as well as preparation method and application of formula

Abstract

The invention relates to the technical field of traditional Chinese medicine preparation, and particularly discloses a formula for treating cold in uterus, dysmenorrhea and cold hands and feet and a preparation method and application thereof.The formula is prepared from, by weight, 1.2 parts of folium artemisiae argyi, 0.6 part of radix dipsaci, 2.4 parts of rhizoma cyperi, 0.8 part of radix astragali, 0.8 part of fructus evodiae, 0.4 part of radix rehmanniae, 0.2 part of cortex cinnamomi, 0.8 part of radix paeoniae alba, 1.2 parts of radix angelicae sinensis, 0.8 part of rhizoma chuanxiong, 1 part of rhizoma atractylodis macrocephalae, 1 part of radix codonopsis and 1.16-1.5 parts of filler. According to the traditional Chinese medicine composition disclosed by the invention, through scientific screening and proportioning, the simplification of a formula and the stability of a medicine effect are ensured. The problems that components in a traditional formula are complex, and interaction is difficult to predict are solved, and the treatment effect and safety of the product are improved. Modern technologies such as ultrasonic cleaning, vacuum drying and superfine grinding are adopted, so that the raw material treatment efficiency and the fineness of the powder are improved. The traditional Chinese medicine composition can effectively treat cold uterus, dysmenorrhea, cold hands and feet and other symptoms, can effectively relieve pain of patients, improves blood circulation and improves the living quality of the patients.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a formula for treating uterine cold dysmenorrhea and cold hands and feet, and a preparation method and application thereof. Background Art

[0002] Dysmenorrhea and cold hands and feet are common health problems for many women, especially in cold seasons or among women with a cold constitution. These problems not only affect women's daily quality of life, but may also have long-term effects on their physical and mental health. Traditionally, Chinese medicine treats such problems with oral medications, acupuncture, cupping, etc. Although these methods can relieve symptoms to a certain extent, they often have problems such as long treatment cycles, different effects from person to person, and poor patient compliance.

[0003] In recent years, with the in-depth study of Chinese medicine external preparations, more and more external powders, plasters and other products have been developed to treat symptoms such as uterine cold, dysmenorrhea and cold hands and feet. These external preparations act directly on the skin and use the penetration of drugs to achieve the purpose of treatment. They have the advantages of easy use, direct effect and few side effects. However, existing external powders or plaster products still have some shortcomings: complex and unstable formulas: In order to pursue efficacy, some products blindly pile up a variety of Chinese medicine ingredients, resulting in complex formulas, unpredictable interactions between ingredients, unstable efficacy, and even possible adverse reactions.

[0004] Moreover, the preparation process of traditional Chinese medicine external preparations includes multiple steps such as cleaning, drying, crushing, mixing, and molding of raw materials. The process is cumbersome and requires high operating skills. It is easy to introduce contamination or cause loss of efficacy during the preparation process.

[0005] Therefore, in view of the problems existing in the prior art, it is urgent to develop an external powder for treating uterine cold dysmenorrhea and cold hands and feet with a streamlined formula, simple preparation process, easy quality control and good usage experience. Summary of the invention

[0006] The purpose of the present invention is to provide a formula for treating uterine cold dysmenorrhea and cold hands and feet, as well as a preparation method and application thereof, so as to solve the problems raised in the above-mentioned background technology.

[0007] To achieve the above object, the present invention provides the following technical solutions:

[0008] A formula for treating uterine cold dysmenorrhea and cold hands and feet, comprising the following steps:

[0009] The invention comprises the following raw materials in parts by weight: 1.2 parts of wormwood leaf, 0.6 parts of dipsaci, 2.4 parts of cyperus rotundus, 0.8 parts of astragalus, 0.8 parts of evodia rutaecarpa, 0.4 parts of rehmannia root, 0.2 parts of cinnamon bark, 0.8 parts of white peony root, 1.2 parts of angelica root, 0.8 parts of ligusticum chuanxiong, 1 part of atractylodes macrocephala, 1 part of codonopsis pilosula, 1.16-1.5 parts of filler, 0.058-0.08 parts of lubricant and 0.58-1.2 parts of adhesive.

[0010] Preferably, the following raw materials are included by weight: 120g of Artemisia argyi, 60g of Dipsacus asper, 240g of Cyperus rotundus, 80g of Astragalus, 80g of Evodia rutaecarpa, 40g of Rehmannia glutinosa, 20g of Cinnamon bark, 80g of White Peony Root, 120g of Angelica sinensis, 80g of Ligusticum chuanxiong, 100g of Atractylodes macrocephala, 100g of Codonopsis pilosula, 116g of filler, 5.8g of lubricant, and 58g of dextrin.

[0011] Preferably, the filler is starch, the lubricant is magnesium stearate, and the binder is dextrin.

[0012] A method for preparing a formula for treating uterine cold dysmenorrhea and cold hands and feet comprises the following steps:

[0013] S1. Raw material pretreatment

[0014] Select the raw materials of Artemisia argyi, Dipsacus asper, Cyperus rotundus, Astragalus membranaceus, Evodia rutaecarpa, Rehmannia root, Cinnamon bark, White peony root, Angelica sinensis, Chuanxiong, Atractylodes macrocephala, Codonopsis pilosula, and use ultrasonic cleaning machine to deeply clean the raw materials to remove dust and impurities on the surface, and pick out impurities, moldy or unqualified parts in the raw materials.

[0015] The washed Chinese medicine raw materials are preliminarily processed to remove excess water, cut into blocks of appropriate size, etc. The pre-treated Chinese medicine raw materials are loaded into a vacuum drying oven, and after closing the drying oven door, the vacuum pump is started to evacuate, heat and dry, and the drying temperature is 50-60°C. Under the vacuum state, the drying oven is heated by the heating element, so that the water in the raw materials is quickly vaporized at a low temperature and discharged from the drying oven. After the drying is completed, the heating element is turned off and the cooling system is turned on to cool the drying oven, and then the drying oven door is opened to take out the dried Chinese medicine raw materials;

[0016] Crushing: Put the pretreated Chinese medicine raw materials into the crusher respectively and crush them to a fineness that can pass through a sieve with a mesh size of 80 or above.

[0017] Use an ultra-fine pulverizer to grind the raw materials to a fineness of more than 300 mesh, and then sieve them finely through a vibrating screen;

[0018] S2. Mixing and preparation of external powder

[0019] The sieved Chinese medicine powder, fine starch, magnesium stearate and moisturizer or skin penetration enhancer are fully mixed to ensure that each powder contains a balanced amount of medicinal ingredients;

[0020] S3. Drying and packaging

[0021] Perform a short drying process at low temperature not exceeding 40°C to remove residual water and moisture;

[0022] Packaging: Put the evenly mixed and dried external powder into a well-sealed plastic bottle to ensure that the powder is not affected by the external environment during use. The drug name, specification, production date, expiration date, usage and precautions should be clearly marked on the container;

[0023] S4. Quality control and inspection Appearance inspection: Check whether the powder appearance is fine and uniform, without lumps and impurities, and the color should be consistent; Particle size inspection: Use a particle size analyzer to detect the particle size distribution of the powder to ensure that it meets the specified fineness requirements; Moisture content inspection: Use a moisture meter to detect the moisture content of the powder to ensure that it is within the specified range; Microbial limit inspection: Conduct microbial limit inspection in accordance with relevant standards to ensure that the powder meets hygiene requirements and will not cause skin infections or allergies; Randomly select packaged powder samples and use an electronic balance to perform weight difference inspection to ensure that the weight of each package / bottle of powder is within the specified range;

[0024] S5. Storage

[0025] Store the packaged external powder in a cool, dry, well-ventilated warehouse or on shelves, avoiding direct sunlight and high temperature and humidity environment to ensure the stability and effectiveness of the powder.

[0026] A formula for treating uterine coldness, dysmenorrhea, and cold hands and feet, which is applied to powder.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] The present invention selects Chinese medicinal raw materials such as wormwood leaf, Radix Dipsaci, Rhizoma Cyperi through scientific screening and proportioning, and optimizes the ratio between each component, thereby ensuring the simplification of the formula and the stability of the drug effect. The problem of complex ingredients and unpredictable interactions in traditional formulas is avoided, and the therapeutic effect and safety of the product are improved. The preparation process of traditional Chinese medicine external preparations is simplified, and modern technologies such as ultrasonic cleaning, vacuum drying, and ultrafine grinding are adopted to improve the efficiency of raw material processing and the fineness of powder. At the same time, through the steps of precise mixing and low-temperature drying, it is ensured that the powder is stably formed and easy to be absorbed by the skin, the quality risk in the preparation process is reduced, and the pain of the patient can be effectively relieved, blood circulation can be improved, and the quality of life of the patient can be improved.

[0029] At the same time, the external powder of the present invention has the advantages of being fine and uniform, easy to apply, non-irritating, etc., and can quickly penetrate the skin to exert a therapeutic effect. At the same time, the powder form is easy to carry and use, is not limited by time and place, and improves the patient's use experience and compliance. DETAILED DESCRIPTION

[0030] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0031] Embodiment 1:

[0032] A Chinese medicine formula for treating uterine coldness, dysmenorrhea, and cold hands and feet:

[0033] Mugwort leaf: 120g

[0034] Dipsacus asper: 60g

[0035] Cyperus rotundus: 240g

[0036] Astragalus: 80g

[0037] Evodia rutaecarpa: 80g

[0038] Rehmannia root: 40g

[0039] Cinnamon: 20g

[0040] White peony root: 80g

[0041] Angelica: 120g

[0042] Chuanxiong: 80g

[0043] Atractylodes macrocephala: 100g

[0044] Codonopsis pilosula: 100g

[0045] Filler (starch): 116g

[0046] Lubricant (magnesium stearate): 5.8 g

[0047] Binder (dextrin): 58g

[0048] Preparation method:

[0049] S1. Raw material pretreatment:

[0050] The above-mentioned Chinese medicinal raw materials are selected and deeply cleaned by using an ultrasonic cleaning machine to remove dust and impurities on the surface, and to pick out impurities, moldy or unqualified parts in the raw materials.

[0051] The cleaned Chinese medicinal materials are preliminarily processed to remove excess moisture and cut into blocks of appropriate sizes.

[0052] Load the pretreated Chinese medicine raw materials into the vacuum drying oven, close the door of the drying oven, start the vacuum pump to start vacuuming, heat and dry to 50-60℃, keep it for a while, so that the moisture in the raw materials can be quickly vaporized at low temperature and discharged from the drying oven.

[0053] After drying is completed, turn off the heating element and turn on the cooling system to cool the drying oven, then open the drying oven door to take out the dried Chinese medicine raw materials.

[0054] The dried Chinese medicine raw materials are crushed to a fineness of more than 300 meshes using an ultrafine pulverizer, and then finely sieved through a vibrating screen to obtain fine Chinese medicine powder.

[0055] S2. Mixing and preparation of external powder:

[0056] Put the sifted Chinese medicine powder, fine starch, magnesium stearate and an appropriate amount of moisturizer (such as glycerin) or skin penetration enhancer (such as menthol) into a mixer and mix them thoroughly to ensure that each powder contains a balanced amount of medicinal ingredients.

[0057] S3. Drying and packaging:

[0058] The mixed powder is briefly dried at low temperature (not exceeding 40°C) to remove residual water and moisture.

[0059] Put the dried and qualified powder into a well-sealed plastic bottle to ensure that the powder is not affected by the external environment during use.

[0060] Clearly mark the drug name, specifications, production date, expiration date, usage and precautions on the container.

[0061] S4. Quality Control and Inspection:

[0062] Check the powder visually to ensure it is fine and uniform, free of lumps and impurities, and that the color is consistent.

[0063] Use a particle size analyzer to test the particle size distribution of the powder to ensure that it meets the specified fineness requirements.

[0064] Use a moisture meter to test the moisture content of the powder to ensure it is within the specified range.

[0065] Carry out microbial limit checks in accordance with relevant standards to ensure that the powder meets hygiene requirements and does not cause skin infections or allergies.

[0066] Randomly select packaged powder samples and use an electronic balance to check the weight difference to ensure that the weight of each bottle of powder is within the specified range.

[0067] S5. Storage:

[0068] Store the packaged external powder in a cool, dry, well-ventilated warehouse or on shelves, avoiding direct sunlight and high temperature and humidity environment to ensure the stability and effectiveness of the powder.

[0069] Effect:

[0070] The external powder for treating uterine cold dysmenorrhea and cold hands and feet prepared in this embodiment has been verified by actual use and has a significant therapeutic effect. After use, the patient can obviously feel the pain relief and warm hands and feet, and it is easy to use and non-irritating, and has been widely praised.

[0071] Embodiment 2:

[0072] A formula for treating uterine coldness, dysmenorrhea, and cold hands and feet:

[0073] Formula composition (by weight):

[0074] Mugwort leaf: 150g

[0075] Dipsacus asper: 75g

[0076] Cyperus rotundus: 300g

[0077] Astragalus: 100g

[0078] Evodia rutaecarpa: 100g

[0079] Rehmannia root: 50g

[0080] Cinnamon: 25g

[0081] White peony root: 100g

[0082] Angelica: 150g

[0083] Chuanxiong: 100g

[0084] Atractylodes macrocephala: 125g

[0085] Codonopsis: 125g

[0086] Filler (corn starch): 145g

[0087] Lubricant (magnesium stearate): 7.5g

[0088] Adhesive (soluble starch slurry): 75g (made by heating soluble starch and water in a ratio of 1:2)

[0089] Preparation method:

[0090] S1. Raw material pretreatment:

[0091] The above-mentioned Chinese medicinal raw materials are carefully selected to ensure that they are free of impurities, mildew or insects.

[0092] Use ultrasonic cleaning equipment to deeply clean the raw materials and remove dust and microorganisms attached to the surface.

[0093] The cleaned raw materials are dried to a suitable moisture content and then cut into small pieces or flakes for subsequent crushing.

[0094] The processed raw materials were placed in a vacuum drying oven, the temperature was set to 55°C, and dried until the moisture content of the raw materials was less than 5%.

[0095] Use an ultra-fine grinder to grind the dried raw materials to a fineness of 400 mesh or above to ensure that the drug ingredients can be fully released.

[0096] S2. Mixing and preparation of external powder:

[0097] Put the crushed Chinese medicine powder, corn starch, magnesium stearate and soluble starch slurry (as a binder) into a three-dimensional mixer and mix them thoroughly to ensure that the ingredients are evenly distributed.

[0098] In order to enhance the skin permeability of the drug, a small amount of peppermint oil can be added during the mixing process as a skin permeation enhancer.

[0099] S3. Drying and packaging:

[0100] The evenly mixed powder was placed in a low-temperature drying oven, the temperature was set to 35°C, and dried until the moisture content of the powder was less than 3%.

[0101] Use an automatic packaging machine to pack the dried powder into aluminum foil bags, and the amount in each bag is precisely controlled to ensure accurate dosage.

[0102] Print information such as drug name, specifications, production date, expiration date, usage and precautions on the aluminum foil bag to ensure that patients can use it correctly.

[0103] S4. Quality Control and Inspection:

[0104] Check the appearance of the powder to ensure that it is in fine powder form, free of lumps, impurities and uniform in color.

[0105] Use a laser particle size analyzer to detect the particle size distribution of the powder to ensure that the fineness reaches 400 mesh or above.

[0106] The moisture content of the powder was tested using a Karl Fischer titrator to ensure that it was within the specified range.

[0107] Conduct microbial limit inspections in accordance with the relevant provisions of the Chinese Pharmacopoeia to ensure that the powder meets hygiene standards.

[0108] Check the weight difference of the packaged powder to ensure that the weight difference of each bag of powder is within the specified range.

[0109] S5. Storage and transportation:

[0110] Store the packaged powder in a cool, dry, well-ventilated warehouse, avoiding direct sunlight and high temperature and humidity environment.

[0111] During transportation, ensure that the powder is not affected by adverse effects such as squeezing, impact or moisture to maintain its stability and effectiveness.

[0112] Embodiment three:

[0113] A Chinese medicine formula for treating uterine coldness, dysmenorrhea, and cold hands and feet:

[0114] Formula composition (by weight, designed for uterine cold and the accompanying abdominal pain due to deficiency and cold):

[0115] Mugwort leaf: 200g (to enhance the effect of warming the meridians and dispelling cold)

[0116] Cinnamon: 50g (to enhance the warming effect)

[0117] Dried ginger: 100g (warms the middle and dispels cold, helps with the effects of mugwort and cinnamon)

[0118] Aconite: 30g (warms yang and dispels cold, for severe cold symptoms)

[0119] White peony root: 150g (relieves pain, harmonizes medicinal properties)

[0120] Yanhusuo: 75g (promotes blood circulation and removes blood stasis, has significant analgesic effect)

[0121] Angelica: 100g (replenishes blood and regulates menstruation, also relieves pain)

[0122] Chuanxiong: 50g (promotes blood circulation and qi, assists the function of angelica)

[0123] Roasted Licorice: 50g (to harmonize the various drugs and enhance their efficacy)

[0124] Filler (microcrystalline cellulose): 120g

[0125] Lubricant (magnesium stearate): 5g

[0126] Moisturizer (glycerin): 10g (to keep the powder moist and facilitate skin absorption)

[0127] Preparation method:

[0128] S1. Raw material preparation and processing:

[0129] All Chinese medicinal materials are selected from high quality products, without impurities or mildew.

[0130] Mugwort, cinnamon, dried ginger and aconite need to be stir-fried separately over low heat until they turn slightly yellow to enhance their ability to warm the yang and dispel cold.

[0131] The remaining medicinal materials were directly crushed into fine powder and passed through a 200-mesh sieve.

[0132] S2. Mixing and blending:

[0133] Mix the fried herbs with other fine powdered herbs evenly.

[0134] Add microcrystalline cellulose, magnesium stearate and glycerin and blend using a V-blender for 30 minutes to ensure that the ingredients are fully incorporated.

[0135] In order to improve the skin adhesion and permeability of the powder, a small amount of natural vegetable oil (such as olive oil) can be added as an auxiliary.

[0136] S3, molding and drying:

[0137] Use a granulator to make it into uniform small particles, which are easy to use and carry.

[0138] The granules were placed in a low-temperature drying oven and dried at 40°C until the moisture content was less than 2% to avoid high temperature damage to the medicinal ingredients.

[0139] S4. Packaging and storage:

[0140] It is packaged in aluminum foil bags with good sealing properties, and the quantity in each bag is determined according to clinical usage requirements.

[0141] The packaging bag must clearly indicate the product name, ingredients, usage and dosage, production date, expiration date and manufacturer.

[0142] Store in a cool, dry place, avoid direct sunlight and high temperatures.

[0143] Usage guidance and effect evaluation:

[0144] When using, take an appropriate amount of powder on the palm of your hand, add appropriate amount of warm water to mix into a paste, apply it around the navel and lower abdomen, fix it with gauze or breathable tape, once a day, each time applying for 4-6 hours.

[0145] One course of treatment is 7 days of continuous use. It is generally recommended to use 2-3 courses of treatment to observe the effect.

[0146] Effect evaluation: Comprehensive evaluation is conducted through indicators such as the degree of abdominal pain relief, improvement in menstrual conditions, and relief of cold hands and feet symptoms reported by the patients.

[0147] Clinical feedback shows that this prescription has a significant improvement effect on symptoms such as cold abdominal pain, irregular menstruation, cold hands and feet caused by uterine cold, and patients tolerate it well with no obvious adverse reactions.

[0148] It will be appreciated that in the development of any actual implementation, as in any engineering or design project, numerous implementation-specific decisions may be made. Such a development effort may be complex and time-consuming, but will be a routine task of design, fabrication, and production for those of ordinary skill having the benefit of this disclosure without undue experimentation.

[0149] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A formula for treating uterine cold dysmenorrhea and cold hands and feet, characterized in that: The invention comprises the following raw materials in parts by weight: 1.2 parts of wormwood leaf, 0.6 parts of dipsaci, 2.4 parts of cyperus rotundus, 0.8 parts of astragalus, 0.8 parts of evodia rutaecarpa, 0.4 parts of rehmannia root, 0.2 parts of cinnamon bark, 0.8 parts of white peony root, 1.2 parts of angelica root, 0.8 parts of ligusticum chuanxiong, 1 part of atractylodes macrocephala, 1 part of codonopsis pilosula, 1.16-1.5 parts of filler, 0.058-0.08 parts of lubricant and 0.58-1.2 parts of adhesive.

2. A formula for treating uterine cold dysmenorrhea and cold hands and feet according to claim 1, characterized in that: The invention comprises the following raw materials by weight: 120g of wormwood leaf, 60g of dipsaci, 240g of cyperus rotundus, 80g of astragalus, 80g of evodia rutaecarpa, 40g of rehmannia root, 20g of cinnamon bark, 80g of white peony root, 120g of angelica sinensis, 80g of ligusticum chuanxiong, 100g of atractylodes macrocephala, 100g of codonopsis pilosula, 116g of filler, 5.8g of lubricant and 58g of dextrin.

3. A formula for treating uterine cold dysmenorrhea and cold hands and feet according to claim 1, characterized in that: The filler is starch, the lubricant is magnesium stearate, and the binder is dextrin.

4. The method for preparing a formula for treating uterine cold dysmenorrhea and cold hands and feet according to claim 1, characterized in that: The following steps are involved: S1. Raw material pretreatment Select the raw materials of Artemisia argyi, Dipsacus asper, Cyperus rotundus, Astragalus membranaceus, Evodia rutaecarpa, Rehmannia root, Cinnamon bark, White peony root, Angelica sinensis, Chuanxiong, Atractylodes macrocephala, Codonopsis pilosula, and use ultrasonic cleaning machine to deeply clean the raw materials to remove dust and impurities on the surface, and pick out impurities, moldy or unqualified parts in the raw materials. The washed Chinese medicine raw materials are preliminarily processed to remove excess water, cut into blocks of appropriate size, etc. The pre-treated Chinese medicine raw materials are loaded into a vacuum drying oven, and after closing the drying oven door, the vacuum pump is started to evacuate, heat and dry, and the drying temperature is 50-60°C. Under the vacuum state, the drying oven is heated by the heating element, so that the water in the raw materials is quickly vaporized at a low temperature and discharged from the drying oven. After the drying is completed, the heating element is turned off and the cooling system is turned on to cool the drying oven, and then the drying oven door is opened to take out the dried Chinese medicine raw materials; Crushing: Put the pretreated Chinese medicine raw materials into the crusher respectively and crush them to a fineness that can pass through a sieve with a mesh size of 80 or above. Use an ultra-fine pulverizer to grind the raw materials to a fineness of more than 300 mesh, and then sieve them finely through a vibrating screen; S2. Mixing and preparation of external powder The sieved Chinese medicine powder, fine starch, magnesium stearate and moisturizer or skin penetration enhancer are fully mixed to ensure that each powder contains a balanced amount of medicinal ingredients; S3. Drying and packaging Perform a short drying process at low temperature not exceeding 40°C to remove residual water and moisture; Packaging: Put the evenly mixed and dried external powder into a well-sealed plastic bottle to ensure that the powder is not affected by the external environment during use. The drug name, specification, production date, expiration date, usage and precautions should be clearly marked on the container; S4. Quality Control and Inspection Appearance inspection: Check whether the powder is fine and uniform in appearance, free of lumps and impurities, and the color should be consistent; Particle size inspection: Use a particle size analyzer to detect the particle size distribution of the powder to ensure that it meets the specified fineness requirements; Moisture content inspection: Use a moisture meter to detect the moisture content of the powder to ensure that it is within the specified range; Microbial limit inspection: Conduct microbial limit inspection in accordance with relevant standards to ensure that the powder meets hygiene requirements and will not cause skin infections or allergies; Randomly select packaged powder samples and use an electronic balance to perform weight difference inspection to ensure that the weight of each package / bottle of powder is within the specified range; S5. Storage Store the packaged external powder in a cool, dry, well-ventilated warehouse or on shelves, avoiding direct sunlight and high temperature and humidity environment to ensure the stability and effectiveness of the powder.

5. A formula for treating uterine cold dysmenorrhea and cold hands and feet according to claim 1-2, characterized in that: For use in powders.