Mouth nicotine product and preparation method thereof

Abstract

The invention relates to a buccal nicotine product and a preparation method thereof. The buccal nicotine product comprises a particle composition, the particle composition comprises a base material, a coating layer coating the surface of the base material and nicotine substances adsorbed on the coating layer, compressed gas is sealed in the base material, the air pressure of the compressed gas is larger than the atmospheric pressure, the base material comprises a soluble material, and when the soluble material is dissolved, the soluble material is separated from the coating layer. The compressed gas is released from the substrate. The buccal nicotine product has the characteristics of quick release and slow release stability.

Description

Technical Field

[0001] This application relates to the technical field of oral products, and particularly to an oral nicotine product and a preparation method thereof. Background Art

[0002] An oral nicotine product is a smokeless product containing nicotine substances. Usually, it does not need to be burned, but the nicotine substances are absorbed by the oral mucosa through being placed in the mouth to provide a certain sense of satisfaction. However, traditional oral nicotine products still have the problem of being difficult to balance the rapid release and stable sustained release of nicotine. Summary of the Invention

[0003] Based on this, some embodiments of this application provide an oral nicotine product that can balance the characteristics of rapid release and stable sustained release.

[0004] In addition, some other embodiments of this application also provide a preparation method of an oral nicotine product.

[0005] An oral nicotine product includes a particulate composition, and the particulate composition includes: a substrate, a coating layer coated on the surface of the substrate, and nicotine substances adsorbed on the coating layer. Among them, compressed gas is sealed inside the substrate, the air pressure of the compressed gas is greater than the atmospheric pressure, the substrate includes a soluble material, and when the soluble material is dissolved, the compressed gas is released from the substrate.

[0006] In some of these embodiments, the substrate includes a filler and a first binder, the compressed gas is carbon dioxide gas, and the filler and the first binder seal the carbon dioxide gas inside the substrate.

[0007] In some of these embodiments, the filler includes one or more of isomalt, polydextrose, maltodextrin, sorbitol, mannitol, microcrystalline cellulose, xanthan gum, and guar gum; and / or,

[0008] The first binder includes at least one of lactitol, glycerol, gum arabic, gelatin, hydroxypropyl methylcellulose, sodium alginate, and lecithin.

[0009] In some of these embodiments, the nicotine substances include at least one of nicotine or nicotine derivatives; and / or,

[0010] The coating layer includes a second binder, and the second binder includes at least one of povidone, cellulose derivatives, pregelatinized starch, syrup, gelatin, gum arabic, sodium alginate, and polyethylene glycol.

[0011] In some of these embodiments, the average particle size of the substrate is 600μm - 1000μm;

[0012] And / or, the thickness of the coating layer is 1 μm to 200 μm.

[0013] In some embodiments, the substrate comprises isomaltulose, sugar-free polydextrose and a first binder, and the coating layer comprises a second binder. By mass, the particulate composition comprises: 20 parts to 80 parts of isomaltulose, 2.5 parts to 15 parts of sugar-free polydextrose, 1.8 parts to 7.2 parts of the first binder, 2.5 parts to 15 parts of the second binder, and 2.3 parts to 9.8 parts of nicotine substances;

[0014] Optionally, the coating layer further comprises a flavor, and the mass fraction of the flavor in the particulate composition is 4.7 parts to 13.5 parts.

[0015] In some embodiments, the oral nicotine product further comprises a permeation bag, and the particulate composition is filled in the permeation bag.

[0016] A method for preparing an oral nicotine product, comprising the following steps:

[0017] Obtain a substrate and a coating solution, wherein the substrate is internally sealed with a compressed gas, the air pressure of the compressed gas is greater than the atmospheric pressure, the substrate comprises a soluble material, and when the soluble material is dissolved, the compressed gas is released from the substrate;

[0018] Coat the substrate with the coating solution to obtain coated sugar pellets having a coating layer;

[0019] Mix the coated sugar pellets with nicotine substances so that the nicotine substances are adsorbed on the coating layer to prepare the oral nicotine product.

[0020] In some embodiments, the preparation steps of the substrate include:

[0021] Mix a filler and a first binder to obtain a mixture;

[0022] Heat and dissolve the mixture with a first solvent, and then vacuum-remove the first solvent to obtain a syrup;

[0023] After filling carbon dioxide gas into the syrup, cool and crush it in sequence to obtain the substrate, and the carbon dioxide gas is sealed inside the substrate.

[0024] In some embodiments, the coating solution comprises a second binder, a flavor and a second solvent, and the second binder comprises at least one of povidone, cellulose derivatives, pregelatinized starch, syrup, gelatin, gum arabic, sodium alginate and polyethylene glycol;

[0025] And / or, in the step of mixing the coated sugar pellets with the nicotine substance, the mixing time is 30 min to 60 min.

[0026] The above-mentioned nicotine-containing oral products include a substrate, a coating layer, and a nicotine substance. When in use, when the nicotine-containing oral product comes into contact with the oral cavity, the soluble material in the substrate dissolves and releases compressed gas, generating an explosive and jumping dynamic experience. At the same time, the soluble material dissolves in water in the oral cavity, causing the internal compressed gas to be released instantaneously, forming an impact effect to diffuse and overflow the nicotine component, thereby increasing the initial release rate of the nicotine substance. The coating layer is coated on the surface of the substrate, and the nicotine substance is adsorbed on the coating layer, which not only ensures the uniform distribution of the compressed gas in the substrate but also avoids the damage of the high-temperature environment during the preparation process of the substrate to the nicotine substance, enabling the nicotine substance to be stably released. Therefore, the above-mentioned nicotine-containing oral products can take into account the characteristics of rapid release and stable slow release. Description of the Drawings

[0027] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the following drawings are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0028] Figure 1 It is a process flow schematic diagram of a preparation method of a nicotine-containing oral product according to some embodiments of the present application;

[0029] Figure 2 It is a test result graph of the total nicotine content of the nicotine-containing oral products of each embodiment;

[0030] Figure 3 It is a test result graph of the moisture content of the nicotine-containing oral products of each embodiment;

[0031] Figure 4 It is a nicotine dissolution data graph of the nicotine-containing oral products of each embodiment;

[0032] Figure 5 It is an explosion effect graph of the nicotine-containing oral products of each embodiment before and after the environmental test;

[0033] Figure 6 It is a result graph of the nicotine content of the nicotine-containing oral products of each embodiment before and after the environmental test;

[0034] Figure 7 It is a graph of the nicotine content decline ratio of the nicotine-containing oral products of each embodiment before and after the environmental test. Detailed Embodiments

[0035] For ease of understanding of the present application, the present application will be described more comprehensively below in conjunction with specific embodiments. Preferred embodiments of the present application are given in the specific embodiments. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided to make the understanding of the disclosure of the present application more thorough and comprehensive.

[0036] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the technical field to which this application belongs. The terms used in the description of this application herein are only for the purpose of describing specific embodiments and are not intended to limit this application. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0037] Unless otherwise stated or there is a contradiction, the terms or phrases used in this application have the following meanings:

[0038] In this application, "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include at least one of such features.

[0039] In the description of this application, "a plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

[0040] In this application, "one or several" means any one, any two or any two or more of the listed items. Among them, "several" means any two or any two or more.

[0041] In this application, "further", "even further", "especially", "for example", "such as", "example", "exemplification", etc. are used for descriptive purposes and indicate that there is an association in the covered content between the different technical solutions before and after, but should not be construed as a limitation on the previous technical solution, nor as a limitation on the scope of protection of this application. In this article, unless otherwise stated, A (such as B) means that B is a non-limiting example in A, and it can be understood that A is not limited to B.

[0042] In this application, "optionally", "optional", "option", mean optional, that is, it means any one of the two alternative options of "having" or "not having". If "optional" appears in a technical solution in multiple places, unless otherwise specified, and there is no contradiction or mutual restriction relationship, each "optional" is independent of each other. In this application, descriptions such as "optionally contain" and "optionally include" mean "contain or not contain". "Optional component X" means that component X is present or absent, or means containing or not containing this component X.

[0043] When a numerical range is disclosed in the present application, the above range is regarded as continuous and includes the minimum value and the maximum value of the range, as well as each value between such minimum and maximum values. Further, when the range refers to integers, it includes each integer between the minimum and maximum values of the range. In addition, when multiple ranges are provided to describe features or characteristics, the ranges can be combined. In other words, unless otherwise specified, all ranges disclosed in the present application should be understood to include any and all sub-ranges subsumed therein.

[0044] In the present application, among the technical features described in an open-ended manner, it includes a closed technical solution composed of the listed features, and also includes an open technical solution containing the listed features.

[0045] The terms "comprise" and "have" and any variations thereof in the embodiments of the present application are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally further includes steps or units not listed, or optionally further includes other steps or components inherent to these processes, methods, products or devices.

[0046] Referring to "embodiment" in the present application means that a specific feature, structure or characteristic described in connection with the embodiment can be included in at least one embodiment of the present application. The appearance of this phrase at various positions in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment mutually exclusive with other embodiments. Those skilled in the art explicitly and implicitly understand that the embodiments described in the present application can be combined with other embodiments.

[0047] In the flow schematic diagram of the present application, although each step is sequentially shown according to the indication of the arrow, these steps are not necessarily carried out in the order indicated by the arrow. Unless there is a clear description in this article, the execution of these steps has no strict order limit, and they can be carried out in other orders. Moreover, at least a part of the steps in the figure can include multiple sub-steps or multiple stages. These sub-steps or stages are not necessarily executed at the same moment, but can be executed at different moments, and their execution order is not necessarily sequential, but can be executed alternately or in turn with at least a part of other steps or other sub-steps or stages.

[0048] The first aspect of the present application provides an oral nicotine product, including a particulate composition, the particulate composition including: a substrate, a coating layer coated on the surface of the substrate, and a nicotine-like substance adsorbed on the coating layer, wherein a compressed gas is sealed inside the substrate, the air pressure of the compressed gas is greater than the atmospheric pressure, the substrate includes a soluble material, and when the soluble material is dissolved, the compressed gas is released from the substrate.

[0049] The above-mentioned nicotine-containing oral products include a base material, a coating layer, and nicotine substances. When in use, when the nicotine-containing oral product comes into contact with the oral cavity, the soluble material in the base material dissolves and releases compressed gas, generating an explosive and jumping dynamic experience. At the same time, the soluble material dissolves in water in the oral cavity, causing the internal compressed gas to be released instantaneously, forming an impact effect to diffuse and overflow the nicotine component, thereby increasing the initial release rate of the nicotine substances. The coating layer is coated on the surface of the base material, and the nicotine substances are adsorbed on the coating layer, which not only ensures the uniform distribution of the gas filled in the base material but also avoids the damage to the nicotine substances caused by the high-temperature environment during the preparation process of the base material, enabling the nicotine substances to be stably released. Therefore, the above-mentioned nicotine-containing oral products can take into account the characteristics of rapid release and stable slow release.

[0050] The types of traditional nicotine-containing oral products are single. Usually, only by adding flavors and flavoring agents to improve the flavor, or using slow-release materials to improve the release rate to attract consumers. In some embodiments of the present application, the nicotine-containing oral product uses a base material with compressed gas sealed inside. When in use, the compressed gas is released, generating an explosive and jumping dynamic experience. In addition, the nicotine release rate of traditional nicotine-containing oral products is relatively slow, and it is difficult to meet the consumer's demand for rapid onset, especially the insufficient release rate in the initial stage, resulting in a poor use experience. While the nicotine-containing oral products in some embodiments of the present application have the characteristics of rapid release, and at the same time take into account stable slow release, improving the use experience.

[0051] In some embodiments, the soluble material is a water-soluble material. A water-soluble material refers to a class of materials that can dissolve in water to form a homogeneous solution. When the particulate composition comes into contact with the oral cavity, the water-soluble material dissolves in water and releases the internal compressed gas.

[0052] In some embodiments, the base material includes a filler and a first binder, the compressed gas is carbon dioxide gas, and the filler and the first binder seal the carbon dioxide gas inside the base material. Specifically, the filler includes a soluble material and may also include some materials that are insoluble in water, such as microcrystalline cellulose. It can be understood that in the present application, carbon dioxide gas refers to a gas mainly composed of carbon dioxide, which can be pure carbon dioxide or a mixed gas including carbon dioxide. In addition, it can be understood that in some other embodiments of the present application, the compressed gas is not limited to carbon dioxide gas, and can also be other compressed gases that can be sealed inside the base material and the air pressure is greater than the atmospheric pressure.

[0053] In the present application, unless otherwise specified, the atmospheric pressure refers to the standard atmospheric pressure, which refers to the air pressure at sea level under standard atmospheric conditions, and its value is 101325 pascals (Pa), and can also be expressed as 760 millimeters of mercury (mmHg).

[0054] In some embodiments, the filler includes one or more of isomalt, polydextrose sugar-free, maltodextrin, sorbitol, mannitol, microcrystalline cellulose, xanthan gum, and guar gum. Optionally, the filler includes isomalt and polydextrose sugar-free. Using the above fillers can further improve the rapid release and stable sustained release properties of the oral nicotine product. In addition, by using isomalt and polydextrose sugar-free as fillers, while providing structural support, the taste and solubility of the product are improved.

[0055] In some of these embodiments, the mass fraction of isomalt in the particulate composition is 20 parts to 80 parts, and the mass fraction of polydextrose sugar-free in the particulate composition is 2.5 parts to 15 parts.

[0056] In one example, the polydextrose sugar-free can be refined polydextrose sugar-free.

[0057] In some embodiments, the first binder includes at least one of lactitol, glycerol, gum arabic, gelatin, hydroxypropyl methylcellulose, sodium alginate, and lecithin. Optionally, the first binder includes at least one of lactitol and sodium alginate. In one example, the lactitol is anhydrous lactitol.

[0058] In some of these embodiments, the mass fraction of the first binder in the particulate composition is 1.8 parts to 7.2 parts.

[0059] In some embodiments, the average particle size of the substrate is 600 μm to 1000 μm. For example, the average particle size of the substrate can be, but is not limited to, 600 μm, 700 μm, 800 μm, 900 μm, 1000 μm, or the range composed of any two of these values.

[0060] By introducing a substrate internally sealed with compressed gas into the oral nicotine product, the product has an explosive feeling and a jumping dynamic experience during use, thus breaking through the traditional oral nicotine product that only attracts consumers by flavor, bringing a new sensory stimulation, and enhancing the attractiveness and market differentiation of the product.

[0061] In some embodiments, the coating layer includes a second binder, and the second binder includes at least one of povidone, cellulose derivatives, pregelatinized starch, syrup, gelatin, gum arabic, sodium alginate, and polyethylene glycol. In one example, the cellulose derivative can be, but is not limited to, hydroxypropyl cellulose. Pregelatinized starch is a modified starch that has gelatinization properties through enzymatic treatment or heat treatment.

[0062] In some embodiments, the second binder is selected from one or more of sodium alginate and hydroxypropyl cellulose.

[0063] In some of these embodiments, the mass parts of the second binder in the particulate composition are from 2.5 parts to 15 parts.

[0064] In some of these embodiments, the first binder and the second binder are different. If the first binder and the second binder are the same, molding cannot be achieved.

[0065] In some of these embodiments, the first binder includes sodium alginate and the second binder includes hydroxypropyl cellulose; alternatively, the first binder includes lactitol and the second binder includes sodium alginate. Using the above binder combination not only ensures the strength of the substrate, but also supports the coating process, improving the fluidization performance of the particles and the finished product quality. In addition, by optimizing the binder and cooperating with other components, the nicotine release and sustained release stability performance of the oral nicotine product can be further improved.

[0066] In some embodiments, the thickness of the coating layer is from 1 μm to 200 μm. For example, the thickness of the coating layer can be, but is not limited to, 1 μm, 10 μm, 20 μm, 50 μm, 80 μm, 100 μm, 120 μm, 150 μm, 180 μm, 200 μm or the range formed by any two of these values.

[0067] In some embodiments, the nicotine-like substances include at least one of nicotine or nicotine derivatives. Specifically, the nicotine-like substances include: free base nicotine, nicotine salts, nicotine in a matrix such as a sugar matrix or an organometallic complex, nicotine-resin combinations, nicotine inclusion complexes, and non-covalently bound nicotine, one or several of which. Among them, non-covalently bound nicotine includes nicotine lactate, nicotine malate, nicotine salicylate, nicotine cyclodextrin inclusion complex, nicotine hydrochloride, nicotine dihydrochloride, nicotine tartrate, nicotine tartrate dihydrate, nicotine sulfate, nicotine zinc chloride, nicotine benzoate, etc. Nicotine derivatives also include nicotine with substituents, such as hexamethyl nicotine, hexamethyl nicotine lactate, hexamethyl nicotine malate, hexamethyl nicotine salicylate, hexamethyl nicotine cyclodextrin inclusion complex, hexamethyl nicotine hydrochloride, hexamethyl nicotine dihydrochloride, hexamethyl nicotine tartrate, hexamethyl nicotine tartrate dihydrate, hexamethyl nicotine sulfate, hexamethyl nicotine zinc chloride, hexamethyl nicotine benzoate, one or more mixtures of which.

[0068] In some of these embodiments, the nicotine-like substances include nicotine salts or nicotine-resin combinations. Using the nicotine salt or nicotine-resin combination form not only improves the stability of nicotine, but also enhances the rapid release effect.

[0069] The nicotine-resin combination refers to an ion-exchange complex formed by nicotine and an ion-exchange resin through an ionic bond. The ion-exchange resin can be those commonly used in the art, such as synthetic ion-exchange resins like polystyrene-based cation-exchange resins, acrylic acid-based cation-exchange resins, modified polyamide resins, modified polyurethane resins, etc., as well as natural ion-exchange resins like chitosan and gum arabic.

[0070] In some of these embodiments, the first binder includes sodium alginate, the second binder includes hydroxypropyl cellulose, and the nicotine substance includes the nicotine-resin combination. In other embodiments, the first binder includes lactitol, the second binder includes sodium alginate, and the nicotine substance includes nicotine salts.

[0071] In some embodiments, the substrate includes isomalt, sugar-free polydextrose, and the first binder, and the coating layer includes the second binder. By mass fraction, the particulate composition includes: 20 parts to 80 parts of isomalt, 2.5 parts to 15 parts of sugar-free polydextrose, 1.8 parts to 7.2 parts of the first binder, 2.5 parts to 15 parts of the second binder, and 2.3 parts to 9.8 parts of the nicotine substance.

[0072] Optionally, the coating layer further includes a flavoring agent, and the mass fraction of the flavoring agent in the particulate composition is 4.7 parts to 13.5 parts. Adding a flavoring agent to the particulate composition can impart a flavor to the oral nicotine product. It can be understood that the types of flavoring agents in this application are not particularly limited, and different flavoring agents can be added according to actual taste requirements, for example, but not limited to, mint flavoring agents.

[0073] Exemplarily, in the particulate composition, the mass fraction of isomalt can be, but not limited to, 20 parts, 30 parts, 40 parts, 50 parts, 60 parts, 70 parts, 80 parts, or the range formed by any two of these values. Optionally, in the particulate composition, the mass fraction of isomalt is 45 parts to 55 parts.

[0074] Exemplarily, in the particulate composition, the mass fraction of sugar-free polydextrose can be, but not limited to, 2.5 parts, 5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 14 parts, 15 parts, or the range formed by any two of these values. Optionally, in the particulate composition, the mass fraction of sugar-free polydextrose is 10 parts to 15 parts.

[0075] Exemplarily, in the particulate composition, the mass fraction of the first binder can be, but not limited to, 1.8 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 6 parts, 7 parts, 7.2 parts, or the range formed by any two of these values. Optionally, in the particulate composition, the mass fraction of the first binder is 3 parts to 4 parts.

[0076] Exemplarily, in the particulate composition, the mass parts of the second binder can be, but are not limited to, 2.5 parts, 5 parts, 7.5 parts, 10 parts, 12.5 parts, 15 parts, or the range formed by any two of these values. Optionally, in the particulate composition, the mass parts of the second binder are 4 parts to 6 parts.

[0077] Exemplarily, in the particulate composition, the mass parts of the flavoring agent can be, but are not limited to, 4.7 parts, 5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 13.5 parts, or the range formed by any two of these values. Optionally, in the particulate composition, the mass parts of the flavoring agent are 9 parts to 10 parts.

[0078] Exemplarily, in the particulate composition, the mass parts of the nicotine-like substances can be, but are not limited to, 2.3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 9.8 parts, or the range formed by any two of these values. Optionally, in the particulate composition, the mass parts of the nicotine-like substances are 4 parts to 5 parts.

[0079] In some of these embodiments, by mass parts, the particulate composition includes: 45 parts to 55 parts of isomaltulose, 10 parts to 15 parts of sugar-free polydextrose, 3 parts to 4 parts of the first binder, 4 parts to 6 parts of the second binder, 9 parts to 10 parts of the flavoring agent, and 4 parts to 5 parts of the nicotine-like substances. Further, by mass parts, the particulate composition includes: 50 parts of isomaltulose, 15 parts of sugar-free polydextrose, 3.5 parts of the first binder, 5 parts of the second binder, 9.5 parts of the flavoring agent, and 4.5 parts of the nicotine-like substances. The release effect of the oral nicotine product with the above formulation ratio is better, and it has a good explosion effect and high stability.

[0080] In some embodiments, the substrate includes isomaltulose, sugar-free polydextrose, and the first binder, and the coating layer includes the second binder. By mass parts, the raw materials for preparing the particulate composition include: 20 parts to 80 parts of isomaltulose, 2.5 parts to 15 parts of sugar-free polydextrose, 1.8 parts to 7.2 parts of the first binder, 6 parts to 18 parts of the solvent, 0.3 parts to 1.5 parts of carbon dioxide gas, 2.5 parts to 15 parts of the second binder, and 2.3 parts to 9.8 parts of the nicotine-like substances.

[0081] In some of these embodiments, by mass parts, the raw materials for preparing the particulate composition include: 20 parts to 80 parts of isomaltulose, 2.5 parts to 15 parts of sugar-free polydextrose, 1.8 parts to 7.2 parts of the first binder, 6 parts to 18 parts of the solvent, 0.3 parts to 1.5 parts of carbon dioxide gas, 2.5 parts to 15 parts of the second binder, 4.7 parts to 13.5 parts of the flavoring agent, and 2.3 parts to 9.8 parts of the nicotine-like substances.

[0082] In one example, the solvent includes water.

[0083] In some of these embodiments, by mass parts, the raw materials for preparing the particulate composition include: 45 to 55 parts of isomaltulose, 10 to 15 parts of sugar-free polydextrose, 3 to 4 parts of a first binder, 10 to 14 parts of a solvent, 0.4 to 0.6 parts of carbon dioxide gas, 4 to 6 parts of a second binder, 9 to 10 parts of a flavor, and 4 to 5 parts of a nicotine substance. Further, by mass parts, the raw materials for preparing the particulate composition include: 50 parts of isomaltulose, 15 parts of sugar-free polydextrose, 3.5 parts of a first binder, 12 parts of a solvent, 0.5 parts of carbon dioxide gas, 5 parts of a second binder, 9.5 parts of a flavor, and 4.5 parts of a nicotine substance. The release effect of the nicotine-containing buccal product prepared according to the above formula ratio is better, and the explosion effect is good and the stability is high.

[0084] In some embodiments, the nicotine-containing buccal product further includes a permeation bag, and the particulate composition is filled in the permeation bag. Among them, the permeation bag refers to a non-woven bag that can permeate saliva.

[0085] The above nicotine-containing buccal product has at least the following advantages:

[0086] (1) By introducing a substrate containing a compressed gas, the above nicotine-containing buccal product has an explosive feeling and a jumping dynamic experience when in use, thereby breaking through the traditional nicotine-containing buccal product that only relies on flavoring to attract consumers, bringing a new sensory stimulation, and enhancing the attractiveness and market differentiation of the product.

[0087] (2) By optimizing the filler and binder, the above nicotine-containing buccal product can further balance the rapid release and stable sustained release properties of nicotine in the product. And the selection of the binder not only ensures the strength of the particles, but also supports the coating process, improving the fluidization performance of the particles and the quality of the finished product.

[0088] Therefore, the above nicotine-containing buccal product can rapidly release nicotine in the oral cavity when in use, providing an obvious physiological stimulation, and at the same time maintaining a long-term effect through a subsequent sustained release mechanism. The explosive taste experience not only meets the consumer's demand for the function of the product, but also greatly enhances the entertainment and experience, and significantly improves the market competitiveness of the product.

[0089] The second aspect of the present application provides a method for preparing a nicotine-containing buccal product, including the following steps:

[0090] Obtain a substrate and a coating solution. The substrate has a compressed gas sealed inside, the air pressure of the compressed gas is greater than the atmospheric pressure, and the substrate includes a soluble material. When the soluble material is dissolved, the compressed gas is released from the substrate;

[0091] Coat the substrate with the coating solution to obtain coated sugar granules, and the coated sugar granules have a coating layer;

[0092] Mix the coated sugar pellets with nicotine substances so that the nicotine substances are adsorbed on the coating layer to prepare oral nicotine products.

[0093] In some embodiments, the preparation steps of the substrate include:

[0094] Mix the filler and the first binder to obtain a mixture;

[0095] Heat and dissolve the mixture with the first solvent, and then remove the first solvent under vacuum to obtain syrup;

[0096] After filling carbon dioxide gas into the syrup, cool and crush it in sequence to obtain the substrate, and the carbon dioxide gas is sealed inside the substrate. Specifically, in the step of mixing the filler and the first binder, the mixing time can be but is not limited to 15 min, as long as the two can be mixed evenly. The mixing time can be adjusted according to the actual production process, and no specific limitation is made in this application. In one example, in the step of mixing the filler and the first binder, a universal mixer is used for mixing. The universal mixer is mainly used for mixing two or more dry powders and granules in industries such as pharmaceuticals, food, chemical engineering, and metallurgy.

[0097] The specific filler and the first binder are as described in the foregoing first aspect, and will not be elaborated here.

[0098] Specifically, in the step of heating and dissolving the mixture with the first solvent, the temperature is 150°C to 220°C, and the time is 30 min to 60 min. By heating and dissolving the mixture with the solvent until complete dissolution, syrup is formed.

[0099] Specifically, the first solvent includes water.

[0100] Specifically, in the step of removing the first solvent under vacuum, it is carried out in a vacuum drying oven. Specifically, the temperature for removing the first solvent under vacuum is 150°C to 300°C, the vacuum degree is -0.1 MPa to -0.03 MPa, and the time is 15 min to 60 min. The specific process parameters for vacuum removal can also be adjusted according to the actual production process.

[0101] In some embodiments, in the step of filling carbon dioxide gas into the syrup, the inflation pressure is 3.5 MPa to 5 MPa, and the time is 15 min to 60 min. The inflation pressure and time can also be adjusted according to the actual production process. Specifically, in the step of filling carbon dioxide gas into the syrup, it is carried out in a reaction kettle.

[0102] Specifically, the mass of the carbon dioxide gas introduced is controlled by controlling the pressure and time of the gas introduced.

[0103] In some embodiments, in the cooling step, the pressure is 3.5 MPa to 5 MPa, and the time is 3 h to 8 h. Specifically, in the cooling step, the reactor is cooled naturally or through a cooling pipe.

[0104] In some embodiments, the crushing step is performed to crush the sugar blocks to an average particle size of 600 μm to 1000 μm. Specifically, the crushing step includes: crushing the block sugar body into sugar particles with an average particle size of 600 μm to 1000 μm using a crushing and granulating machine, and then sieving with a 20-mesh screen to obtain a granular popping candy base material, and discarding the fine powder.

[0105] In some embodiments, the coating solution comprises a second binder, a flavor, and a second solvent, and the second binder comprises at least one of povidone, a cellulose derivative, pregelatinized starch, syrup, gelatin, gum arabic, sodium alginate, and polyethylene glycol.

[0106] In one example, the second solvent includes water.

[0107] In some embodiments, in the coating step, the second binder and the flavor are dissolved in the second solvent to prepare a coating solution, and the substrate is coated with the coating solution. Specifically, in the coating step, the water content of the coated sugar granules is controlled within 5%.

[0108] Specifically, during the coating process, the temperature is controlled at 50°C, the speed of the coating machine is set to 40 rpm, and the spraying speed is 0.5 g / min to 2 g / min. The process parameters of the coating process can also be adjusted according to the actual production process.

[0109] The above preparation method realizes stable coating and surface volume control of sugar particles through high-temperature vacuum drying and reactor molding technology, and further through fluidized bed coating process.

[0110] In some embodiments, in the step of mixing the coated sugar granules with the nicotine-like substance, the mixing time is 30 minutes to 60 minutes. The mixing time can also be adjusted according to the actual production process. Specifically, a universal mixer or a common mixer is used for mixing.

[0111] In some embodiments, the nicotine-like substance includes a nicotine-resin combination, which is obtained by mixing the resin and nicotine at room temperature for 15 minutes. In other embodiments, the nicotine-like substance includes nicotine salt.

[0112] In the above preparation method, nicotine is mixed into the process at a later stage, which not only ensures the uniform distribution of gas but also avoids the destruction of active ingredients (such as nicotine) by high temperature, thereby improving the storage stability and use effect of the oral nicotine product.

[0113] In some embodiments, seeFigure 1 , the preparation method of the oral nicotine product includes the following steps S110, S120, S130 and S140:

[0114] Step S110: Mix a filler and a first binder to obtain a mixture; heat and dissolve the mixture with a first solvent, and then vacuum-remove the first solvent to obtain a syrup.

[0115] Step S120: After filling carbon dioxide gas into the syrup, cool and crush it in sequence to obtain a base material, and the carbon dioxide gas is sealed inside the base material.

[0116] Step S130: Coat the base material with a coating solution containing a second binder to obtain coated sugar pellets, and the coated sugar pellets have a coating layer.

[0117] Step S140: Mix the coated sugar pellets with nicotine substances so that the nicotine substances are adsorbed on the coating layer to prepare the oral nicotine product.

[0118] In some embodiments, it further includes: encapsulating the oral nicotine product. Specifically, use an oral nicotine product bagging machine to complete non-woven fabric encapsulation, boxing, and plastic sealing.

[0119] The above preparation method of the oral nicotine product has at least the following advantages:

[0120] (1) By introducing a base material with compressed gas sealed inside into the oral nicotine product, the above preparation method of the oral nicotine product makes the product have an explosive feeling and a jumping dynamic experience when in use, thus breaking through the traditional oral nicotine products that only attract consumers by flavor, bringing a brand-new sensory stimulation, and enhancing the attractiveness and market differentiation of the product. In addition, through steps such as gas filling, high-pressure cooling molding, and fluidized bed coating, the particle uniformity and stability of the product are ensured, and finally a high-performance oral nicotine product that can meet the long-term use requirements of both fast-release and slow-release spray particles is realized, improving the overall experience of users and market competitiveness.

[0121] (2) Through high-temperature vacuum drying and reactor molding technology, and further through the fluidized bed coating process, the above preparation method of the oral nicotine product realizes the stable coating and surface quantity control of sugar pellets, and places the process of mixing nicotine later, which not only ensures the uniform distribution of gas but also avoids the damage of high temperature to active ingredients (such as nicotine), thereby improving the storage stability and use effect of the finished product.

[0122] Therefore, when the nicotine-containing oral products prepared by the above preparation method are used, they can achieve rapid release of nicotine in the oral cavity, provide obvious physiological stimulation, and maintain a long-term effect through subsequent sustained-release mechanisms; the explosive taste experience not only meets the consumer's demand for the function of the product, but also greatly enhances the entertainment and experience, significantly improves the market competitiveness of the product, and can effectively solve the technical bottlenecks of traditional nicotine-containing oral products in terms of single experience, uneven release, innovation and deficiencies, providing a new type of high-performance and multi-sensory stimulating nicotine-containing oral product for the market.

[0123] In order to make the purpose and advantages of this application clearer, the following further details the nicotine-containing oral products of this application and their effects with specific embodiments. It should be understood that the specific embodiments described here are only used to explain this application and should not be used to limit this application. Unless otherwise specified, the following embodiments do not include other components except inevitable impurities. The drugs and instruments used in the embodiments are all conventional selections in the art unless otherwise specified. The experimental methods without specific conditions in the embodiments are carried out under conventional conditions, such as the conditions described in the literature, books or the methods recommended by the manufacturers.

[0124] Example 1

[0125] This example provides a nicotine-containing oral product. Calculated by mass fraction, the composition of its preparation raw materials is as follows: 50 parts of isomaltulose, 4.5 parts of nicotine bitartrate dihydrate, 15 parts of refined sugar-free polydextrose, 12 parts of deionized water, 5 parts of sodium alginate, 3.5 parts of anhydrous lactitol, 0.5 part of carbon dioxide and 9.5 parts of mint flavor essence.

[0126] The preparation method of the nicotine-containing oral product in this example includes the following steps:

[0127] (1) Weigh isomaltulose, refined sugar-free polydextrose and anhydrous lactitol according to the formula ratio, mix them with a universal mixer for 15 minutes to obtain a mixture. Add the mixture and part of deionized water (80% of all deionized water) into the reaction kettle device, heat to 150 °C and stir for about 30 minutes until completely dissolved to form a syrup. Transfer the dissolved syrup to a vacuum drying oven and keep it for 40 minutes at an environmental temperature of 150 °C and a vacuum degree of -0.06 MPa for dehydration to obtain the dehydrated syrup.

[0128] (2) Transfer the syrup after vacuum dehydration into the reaction kettle, continuously stir mechanically and inject carbon dioxide gas in a fixed proportion into the syrup. The inflation pressure is 3.5 MPa and the inflation time is 15 minutes. Let the inflated syrup cool and form naturally in the reaction kettle. The forming pressure is maintained at 3.5 MPa and the cooling time is 5 h to obtain a block sugar body substrate. Use a crushing and sizing machine to crush and size the block sugar body into sugar grains with a diameter of 800 μm, and then sieve it through a 20-mesh sieve to obtain a granular substrate, discarding the fine powder.

[0129] (3) Dissolve sodium alginate and mint flavor essence in the remaining deionized water (accounting for 20% of all deionized water) to prepare a coating solution, and use the fluidized coating method to treat the substrate to obtain coated sugar grains, controlling the water content of the coated sugar grain powder within 5%.

[0130] (8) Weigh a fixed proportion of nicotine bitartrate dihydrate, and mix it with the coated sugar grains using a universal mixer for 45 min to obtain the finished powder. Use a mouth nicotine pouch packaging machine to complete the non-woven fabric packaging, boxing, and plastic sealing of the finished powder to obtain the mouth nicotine product of this example.

[0131] Example 2

[0132] This example provides a mouth nicotine product. Calculated by mass fraction, the composition of its preparation raw materials is as follows: isomalt 20 parts, nicotine bitartrate dihydrate 4.5 parts, refined sugar-free polydextrose 16.5 parts, deionized water 18 parts, sodium alginate 16.5 parts, anhydrous lactitol 9.5 parts, carbon dioxide 1.5 parts, and mint flavor essence 13.5 parts.

[0133] The preparation method of the mouth nicotine product in this example is the same as that in Example 1 and will not be elaborated here.

[0134] Example 3

[0135] This example provides a mouth nicotine product. Calculated by mass fraction, the composition of its preparation raw materials is as follows: isomalt 80 parts, nicotine bitartrate dihydrate 4.5 parts, refined sugar-free polydextrose 1.4 parts, deionized water 6 parts, sodium alginate 1.4 parts, anhydrous lactitol 1.8 parts, carbon dioxide 0.3 parts, and mint flavor essence 4.7 parts.

[0136] The preparation method of the mouth nicotine product in this example is the same as that in Example 1 and will not be elaborated here.

[0137] Example 4

[0138] This embodiment provides an oral nicotine product. By mass fraction, the composition of its preparation raw materials is as follows: 50 parts of isomaltulose, 4.5 parts of nicotine resin, 15 parts of refined sugar-free polydextrose, 12 parts of deionized water, 5 parts of hypromellose, 3.5 parts of sodium alginate, 0.5 part of carbon dioxide, and 9.5 parts of mint flavor essence.

[0139] The preparation method of the oral nicotine product in this embodiment includes the following steps:

[0140] (1) Weigh isomaltulose, refined sugar-free polydextrose, and sodium alginate according to the formula ratio, and mix them with a universal mixer for 15 min to obtain a mixture. Add the mixture and part of the deionized water (80% of the total deionized water) into the reaction kettle device, heat to 150 °C and stir for about 30 min until completely dissolved to form a syrup. Transfer the dissolved syrup to a vacuum drying oven, and keep it for 40 min at an environmental temperature of 150 °C and a vacuum degree of -0.06 MPa for dehydration to obtain the dehydrated syrup.

[0141] (2) Transfer the syrup after vacuum dehydration into the reaction kettle, continuously mechanically stir and charge carbon dioxide with a fixed ratio into the syrup. The inflation pressure is 3.5 MPa, and the inflation time is 15 minutes. Let the inflated syrup cool and form naturally in the reaction kettle. The forming pressure is kept at 3.5 MPa, and the cooling time is 5 h to obtain a block-shaped sugar body substrate. Use a crushing and sizing machine to crush and size the block-shaped sugar body into sugar grains with a diameter of 800 μm, and then sieve it through a 20-mesh sieve to obtain a granular substrate, discarding the fine powder.

[0142] (3) Dissolve hypromellose and mint flavor essence in the remaining deionized water (20% of the total deionized water) to prepare a coating solution, and use fluidized coating to treat the substrate to obtain coated sugar grains, controlling the water content of the coated sugar grain powder within 5%.

[0143] (8) Mix nicotine and resin (specifically polystyrene-based cation exchange resin) in a mass ratio of 1:1, and stir at room temperature for 15 min to obtain nicotine resin. Weigh a fixed ratio of nicotine resin and coated sugar grains and mix them with a universal mixer for 45 min to obtain the finished powder. Use an oral tobacco sealing bag machine to complete the non-woven fabric encapsulation, boxing, and plastic sealing of the finished powder to obtain the oral nicotine product of this embodiment.

[0144] Example 5

[0145] This embodiment provides an oral nicotine product. By mass fraction, the composition of its preparation raw materials is as follows: 20 parts of isomaltitol, 4.5 parts of nicotine resin, 16.5 parts of refined sugar-free polydextrose, 18 parts of deionized water, 16.5 parts of hypromellose, 9.5 parts of sodium alginate, 1.5 parts of carbon dioxide, and 13.5 parts of mint flavor essence.

[0146] The preparation method of the oral nicotine product in this embodiment is the same as that of Example 4 and will not be elaborated here.

[0147] Example 6

[0148] This embodiment provides an oral nicotine product. By mass fraction, the composition of its preparation raw materials is as follows: 80 parts of isomaltitol, 4.5 parts of nicotine resin, 1.4 parts of refined sugar-free polydextrose, 6 parts of deionized water, 1.4 parts of hypromellose, 1.8 parts of sodium alginate, 0.3 parts of carbon dioxide, and 4.7 parts of mint flavor essence.

[0149] The preparation method of the oral nicotine product in this embodiment is the same as that of Example 4 and will not be elaborated here.

[0150] The raw material compositions of the oral nicotine products in the above embodiments are shown in Table 1 and Table 2 below.

[0151] Table 1

[0152]

[0153] Table 2

[0154]

[0155] Take 300 g of the oral nicotine products prepared in the above embodiments and comparative examples for the following performance detection and analysis.

[0156] 1. Nicotine content detection: Based on HPLC-AglientGC 8890 test, reagents: isopropanol (chromatographic grade), ethanol (chromatographic grade); standard products: nicotine standard solution in isopropanol, n-heptadecane (internal standard).

[0157] The test results of the total nicotine content of the oral nicotine products in the above embodiments are as Figure 2 shown. It can be seen from Figure 1 that the initial nicotine contents of Examples 1 to 3 (i.e., Formulas A, B, and C) are relatively high, being 35.73 mg / g, 34.25 mg / g, and 35.66 mg / g respectively. The initial nicotine contents of Examples 4 to 6 (i.e., Formulas D, E, and F) are relatively low, around 16 mg / g to 17 mg / g.

[0158] 2. Moisture content detection: Tested based on the Japanese KEM 710S-ADP611 device.

[0159] The moisture content test results of the nicotine-containing oral products of the above embodiments are as Figure 3 shown. It can be seen from Figure 3 that the moisture content of the nicotine-containing oral products of each embodiment is far lower than 5% (the moisture content requirement is within 5%), indicating that in terms of moisture content, the nicotine-containing oral products of each embodiment meet the requirements. The lower moisture content helps to maintain the stability and quality of the products.

[0160] 3. Nicotine dissolution ratio detection: Tested based on the Agilent 708-DS dissolution tester. Method: paddle method, rotation speed: 50 rpm; dissolution medium: 0.8 g / L potassium chloride solution; adjust the pH value to 6.8 with sodium bicarbonate; dissolution volume: 500 mL; filter membrane: 0.2 μm; sampling volume: 1.5 mL, without replenishing the solution.

[0161] The nicotine dissolution data of the nicotine-containing oral products of the above embodiments are shown in Table 3 and Figure 4 as shown.

[0162] Table 3

[0163]

[0164] It can be seen from Table 3 and Figure 4 that:

[0165] (1) Initial dissolution (1 min to 5 min): The dissolution rates of Examples 1 to 3 (Formulas A, B, and C) are significantly faster in the initial stage, and the nicotine release amount has reached 20 to 30 mg / g within 1 to 5 minutes. While the initial dissolution of Examples 4 to 6 (Formulas D, E, and F) is slower, and at the same time point, the release amount is 3 to 7 mg / g, indicating that their dissolution power is weaker.

[0166] (2) Middle-stage dissolution (10 min to 30 min): The butyl salt systems of Examples 1 to 3 have approached the dissolution plateau (about 30 to 35 mg / g) at 10 minutes, and the subsequent growth is relatively slow. The dissolution rates of the resin butyl systems of Examples 4 to 6 are stable between 10 and 30 minutes, and the dissolution amount gradually increases, indicating that their release processes are milder.

[0167] (3) Final-stage dissolution (45 min to 60 min): The butyl salt systems of Examples 1 to 3 basically remain constant after 20 minutes, and the dissolution amount is close to 35 mg / g. The dissolution amount of the resin butyl systems of Examples 4 to 6 remains stable at about 45 minutes.

[0168] Therefore, it can be seen that the nicotine salt systems of Examples 1 to 3 are suitable for rapid nicotine release to meet the stimulation requirements within a short time. The resin nicotine systems of Examples 4 to 6 are suitable for delayed release to provide a longer-lasting effect.

[0169] 4. Product stability test: Environmental test conditions: temperature 50°C, humidity 80%, placement time 72 hours.

[0170] The explosion effects of the oral nicotine products of each example before and after the environmental test are as Figure 5 shown. Among them, the explosion effect level standard is as follows: Level 1 = no explosion taste, Level 2 = slight explosion taste, Level 3 = normal explosion taste, Level 4 = stronger explosion taste, Level 5 = strong explosion taste.

[0171] The initial explosion effect of Example 1 (Formulation A) was Level 5 and decreased to Level 4 after the environmental test (abbreviated as environmental test). It can still maintain a certain explosion effect under high temperature and high humidity conditions, and the stability is good. The initial explosion effect of Example 2 (Formulation B) was Level 3 and decreased to Level 1 after the environmental test. The explosion decreased significantly instantaneously, and the explosion effect was not stable under environmental conditions. The initial explosion effect of Example 3 (Formulation C) was Level 2 and remained at Level 2 after the environmental test, with little change. The stability is good but the initial explosion effect is weak. The initial explosion effect of Example 4 (Formulation D) was Level 4 and decreased to Level 3 after the environmental test. The stability is good and a certain explosion effect is maintained. The initial explosion effects of Examples 5 and 6 (Formulations E and F) were Level 3 and Level 2 respectively, and decreased to Level 1 and Level 2 after the environmental test. The explosion effect decreased significantly and was not stable under environmental conditions.

[0172] The nicotine content results of the oral nicotine products of each example before and after the environmental test are as Figure 6 shown, and the nicotine content decrease ratios before and after the environmental test are as Figure 7 shown. From Figure 6 and Figure 7 it can be seen that the nicotine decrease ratio of Example 1 (Formulation A) is the largest (28.5%). Although the explosion effect remains the same, high temperature and high humidity have a greater impact on nicotine stability. The decrease ratio of Example 6 (Formulation F) is the smallest (10.6%), indicating that its nicotine system is more stable to environmental conditions. However, overall, the nicotine change differences between the two basic formulation systems of Examples 1 to 3 and Examples 4 to 6 are not very large. The stability of the nicotine salt system of Examples 1 to 3 is slightly weaker than that of the resin nicotine system of Examples 4 to 6.

[0173] Therefore, in practical applications, the oral nicotine products of the present application can also adjust the formulation ratio according to specific requirements for explosion effect, stability, total nicotine amount, nicotine dissolution effect, etc. to meet various different needs.

[0174] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as falling within the scope described in this specification.

[0175] The above-described embodiments merely represent several implementation manners of the present application, which are convenient for understanding the technical solutions of the present application specifically and in detail, but should not be construed as a limitation on the protection scope of the invention patent. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present application, several modifications and improvements can still be made, and these all belong to the protection scope of the present application. It should be understood that the technical solutions obtained by those skilled in the art through logical analysis, reasoning or limited experiments based on the technical solutions provided in the present application are all within the protection scope of the appended claims of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the content of the appended claims, and the description and drawings can be used to explain the content of the claims.

Claims

1. An oral nicotine product, characterized in that: The invention comprises a particle composition, wherein the particle composition comprises: a substrate, a coating layer coated on the surface of the substrate, and a nicotine-like substance adsorbed on the coating layer, wherein compressed gas is sealed inside the substrate, the gas pressure of the compressed gas is greater than the atmospheric pressure, the substrate comprises a soluble material, and when the soluble material is dissolved, the compressed gas is released from the substrate.

2. The oral nicotine product according to claim 1, characterized in that The substrate includes a filler and a first adhesive, the compressed gas is carbon dioxide gas, and the filler and the first adhesive seal the carbon dioxide gas inside the substrate.

3. The oral nicotine product according to claim 2, characterized in that The filler comprises one or more of isomalt, sugar-free polydextrose, maltodextrin, sorbitol, mannitol, microcrystalline cellulose, xanthan gum and guar gum; and / or, The first binder includes at least one of lactitol, glycerin, gum arabic, gelatin, hydroxypropyl methylcellulose, sodium alginate and lecithin.

4. The oral nicotine product according to claim 1, characterized in that The nicotine-like substance includes at least one of nicotine or a nicotine derivative; and / or, The coating layer includes a second binder, and the second binder includes at least one of povidone, a cellulose derivative, pregelatinized starch, syrup, gelatin, gum arabic, sodium alginate and polyethylene glycol.

5. The oral nicotine product according to claim 1, characterized in that The average particle size of the substrate is 600 μm to 1000 μm; and / or, The coating layer has a thickness of 1 μm to 200 μm.

6. The oral nicotine product according to any one of claims 1 to 5, characterized in that The substrate comprises isomalt, sugar-free polydextrose and a first adhesive, the coating layer comprises a second adhesive, and the granule composition comprises, by weight: 20 to 80 parts of isomalt, 2.5 to 15 parts of sugar-free polydextrose, 1.8 to 7.2 parts of the first adhesive, 2.5 to 15 parts of the second adhesive and 2.3 to 9.8 parts of nicotine-like substances; Optionally, the coating layer further comprises flavor, and the mass fraction of the flavor in the granular composition is 4.7 parts to 13.5 parts.

7. The oral nicotine product according to any one of claims 1 to 5, characterized in that The oral nicotine product further comprises an osmotic bag, in which the granular composition is filled.

8. A method for preparing an oral nicotine product, characterized in that: The steps include: Obtaining a substrate and a coating solution, wherein compressed gas is sealed inside the substrate, the pressure of the compressed gas is greater than atmospheric pressure, the substrate comprises a soluble material, and when the soluble material is dissolved, the compressed gas is released from the substrate; The substrate is coated with the coating solution to obtain coated sugar particles, wherein the coated sugar particles have a coating layer; The coated sugar granules are mixed with nicotine-like substances, and the nicotine-like substances are adsorbed on the coating layer to prepare the oral nicotine product.

9. The method for preparing an oral nicotine product according to claim 8, characterized in that: The preparation steps of the substrate include: mixing a filler and a first binder to obtain a mixture; heating the mixture and the first solvent to dissolve, and then removing the first solvent under vacuum to obtain a syrup; After the carbon dioxide gas is charged into the syrup, the syrup is cooled and crushed in sequence to obtain the substrate, and the carbon dioxide gas is sealed inside the substrate.

10. The method for preparing an oral nicotine product according to any one of claims 8 to 9, characterized in that: The coating solution comprises a second binder, a flavor, and a second solvent, wherein the second binder comprises at least one of povidone, a cellulose derivative, pregelatinized starch, syrup, gelatin, gum arabic, sodium alginate, and polyethylene glycol; And / or, in the step of mixing the coated sugar granules with the nicotine-like substance, the mixing time is 30 min to 60 min.

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